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CENPE Gene

protein-coding   GIFtS: 64
GCID: GC04M104027

Centromere Protein E, 312kDa

(Previous name: centromere protein E (312kD))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein E, 312kDa1 2     PPP1R612
Kinesin-Related Protein CENPE2 3     Centromere Autoantigen E (312kD)2
CENP-E2 3     Centromere-Associated Protein E2
Centromere Protein E (312kD)1     Kinesin Family Member 102
Protein Phosphatase 11     Protein Phosphatase 1, Regulatory Subunit 612
Regulatory Subunit 611     Centromere Protein E3
KIF102     

External Ids:    HGNC: 18561   Entrez Gene: 10622   Ensembl: ENSG000001387787   OMIM: 1171435   UniProtKB: Q022243   

Export aliases for CENPE gene to outside databases

Previous GC identifers: GC04M104426 GC04M104486 GC04M104384 GC04M104246 GC04M099760


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPE Gene:
Centrosome-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell
cycle. Unlike other centrosome-associated proteins, it is not present during interphase and first appears at the
centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for
mammalian chromosome movement and/or spindle elongation. (provided by RefSeq, Jul 2008)

GeneCards Summary for CENPE Gene:
CENPE (centromere protein E, 312kDa) is a protein-coding gene. GO annotations related to this gene include microtubule binding and kinetochore binding. An important paralog of this gene is KIF4A.

UniProtKB/Swiss-Prot: CENPE_HUMAN, Q02224
Function: Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule
capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during
mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment.
Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent
motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking
kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual
kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of
BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity.
Accumulates just before mitosis at the G2 phase of the cell cycle

Gene Wiki entry for CENPE (Centromere protein E) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000004.11  NC_018915.2  NT_016354.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CENPE gene promoter:
         ISGF-3   Pbx1a   FOXF2   Pax-2   Pax-2a   E4BP4   C/EBPalpha   POU2F1a   ATF   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPE promoter sequence
   Search Chromatin IP Primers for CENPE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q24-q25   Ensembl cytogenetic band:  4q24   HGNC cytogenetic band: 4q24-q25

CENPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPE gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M104027:  view genomic region     (about GC identifiers)

Start:
104,026,963 bp from pter      End:
104,119,566 bp from pter
Size:
92,604 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPE_HUMAN, Q02224 (See protein sequence)
Recommended Name: Centromere-associated protein E precursor  
Size: 2701 amino acids; 316415 Da
Subunit: Monomer. Interacts with CENPF, SEPT7, KIF18A, BUB1B kinase and PRC1. Interacts with NUF2; this
interaction determines kinetochore localization. Interacts with SKAP; this interaction greatly favors SKAP
binding to microtubules
Sequence caution: Sequence=BAE06078.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
1 PDB 3D structure from and Proteopedia for CENPE:
1T5C (3D)    
Secondary accessions: A6NKY9 A8K2U7 Q4LE75
Alternative splicing: 3 isoforms:  Q02224-1   Q02224-2   Q02224-3   

Explore the universe of human proteins at neXtProt for CENPE: NX_Q02224

Explore proteomics data for CENPE at MOPED

Post-translational modifications: 

  • The C-terminal inhibitory domain is phosphorylated. Phosphorylation relieves autoinhibition of the kinetochore
    motor (By similarity)1
  • Sumoylated with SUMO2 and SUMO3. The sumoylation mediates the association to the kinetochore1
  • Ubiquitination2 at Lys1937
  • Modification sites at PhosphoSitePlus

  • See CENPE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273663.1  NP_001804.2  

    ENSEMBL proteins: 
     ENSP00000369365   ENSP00000423981   ENSP00000426023   ENSP00000265148  
    Reactome Protein details: Q02224

    CENPE Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CENPE

     
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    Cloud-Clone Corp. ELISAs for CENPE
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    Search eBioscience for ELISAs for CENPE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    KIF: Kinesins
    PPP1R: Serine/threonine phosphatases / Protein phosphatase 1, regulatory subunits

    5 InterPro protein domains:
     IPR028368 CENPE
     IPR001752 Kinesin_motor_dom
     IPR027417 P-loop_NTPase
     IPR019821 Kinesin_motor_CS
     IPR027640 Kinesin-like_fam

    Graphical View of Domain Structure for InterPro Entry Q02224

    ProtoNet protein and cluster: Q02224

    1 Blocks protein domain: IPB001752 Kinesin

    UniProtKB/Swiss-Prot: CENPE_HUMAN, Q02224
    Domain: The protein is composed of a N-terminal kinesin-motor domain involved in the chromosome movements, a long
    coil-coiled region involved in the homodimerization and an inhibitory C-tail involved in autoinhibition of the
    N-terminal catalytic part (By similarity)
    Similarity: Belongs to the kinesin-like protein family
    Similarity: Contains 1 kinesin-motor domain


    Find genes that share domains with CENPE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPE_HUMAN, Q02224
    Function: Essential for the maintenance of chromosomal stability through efficient stabilization of microtubule
    capture at kinetochores. Plays a key role in the movement of chromosomes toward the metaphase plate during
    mitosis. Is a slow plus end-directed motor whose activity is essential for metaphase chromosome alignment.
    Couples chromosome position to microtubule depolymerizing activity. The highly processive microtubule-dependent
    motor activity of CENPE serves to power chromosome congression and provides a flexible, motile tether linking
    kinetochores to dynamic spindle microtubules. Necessary for the mitotic checkpoint signal at individual
    kinetochores to prevent aneuploidy due to single chromosome loss. Required for the efficient recruitment of
    BUBR1, MAD1 and MAD2 to attached and newly unattached kinetochores. Stimulates mammalian BUBR1 kinase activity.
    Accumulates just before mitosis at the G2 phase of the cell cycle

         Genatlas biochemistry entry for CENPE:
    centromere protein E (312kDa),component of the outer kinetochore,microtubule associated kinesin motor protein,ATP
    dependent superfamily,required for the metaphase-anaphase transition in mitosis and meiosis II

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0003777microtubule motor activity IMP7889940
    GO:0004871signal transducer activity ----
    GO:0005515protein binding IPI17535814
    GO:0005524ATP binding IEA--
         
    Find genes that share ontologies with CENPE           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for CENPE:
     Decreased cell number  Increased gamma-H2AX phosphory  Increased number of mitotic ce  Synthetic lethal with Ras 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cenpe):
     cellular  embryogenesis  liver/biliary system  mortality/aging 

    Find genes that share phenotypes with CENPE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cenpetm1Dwc for CENPE

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CENPE

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    miRNA
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    miRTarBase miRNAs that target CENPE:
    hsa-mir-215-5p (MIRT024490), hsa-mir-192-5p (MIRT026236)

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    SwitchGear 3'UTR luciferase reporter plasmidCENPE 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPE

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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPE
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CENPE

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPE_HUMAN, Q02224: Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Note=Associates with
    kinetochores during congression (as early as prometaphase), relocates to the spindle midzone at anaphase, and is
    quantitatively discarded at the end of the cell division
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA11084331
    GO:0000776kinetochore IDA11682612
    GO:0000778condensed nuclear chromosome kinetochore IEA--
    GO:0000779condensed chromosome, centromeric region IDA19465021
    GO:0000940colocalizes with condensed chromosome outer kinetochore TAS9763420

    Find genes that share ontologies with CENPE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPE About   (see all 9)  
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92
    4Hemostasis
    Hemostasis0.43
    5Class I MHC mediated antigen processing and presentation
    Adaptive Immune System0.41


    Find genes that share SuperPaths with CENPE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for CENPE
        PLK1 signaling events

    5 Reactome Pathways for CENPE
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids
    MHC class II antigen presentation
    Kinesins


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPE
    Interactions:

        GeneGlobe Interaction Network for CENPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPE (Q022241, 2, 3 ENSP000002651484) via UniProtKB, MINT, STRING, and/or I2D (see all 169)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NUF2Q9BZD41, 3, ENSP000002714524EBI-1375040,EBI-724102 I2D: score=2 STRING: ENSP00000271452
    BUB1BO605661, 3, ENSP000002875984EBI-1375040,EBI-1001438 I2D: score=4 STRING: ENSP00000287598
    SKA1Q96BD82, 3, ENSP000002851164MINT-3391266 I2D: score=1 STRING: ENSP00000285116
    CUL1Q136163, ENSP000003268044I2D: score=1 STRING: ENSP00000326804
    FANCAO153603, ENSP000003739524I2D: score=1 STRING: ENSP00000373952
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000089mitotic metaphase TAS2022189
    GO:0000278mitotic cell cycle TAS--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006614SRP-dependent cotranslational protein targeting to membrane ----
    GO:0007018microtubule-based movement TAS--

    Find genes that share ontologies with CENPE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPE

    7 Novoseek inferred chemical compound relationships for CENPE gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monastrol 71.1 1 15136168 (1)
    lonafarnib 66.4 2 17431110 (2)
    nocodazole 40.8 3 12235289 (1), 15181147 (1)
    vinblastine 17.4 2 8894282 (2)
    atp 0 1 19759394 (1)
    gold 0 2 11056662 (1), 9391217 (1)
    paclitaxel 0 1 11451998 (1)



    Find genes that share compounds with CENPE           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CENPE gene (2 alternative transcripts): 
    NM_001286734.1  NM_001813.2  

    Unigene Cluster for CENPE:

    Centromere protein E, 312kDa
    Hs.75573  [show with all ESTs]
    Unigene Representative Sequence: NM_001813
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380026(uc003hxd.1) ENST00000509823 ENST00000515478 ENST00000503705
    ENST00000509120 ENST00000514974 ENST00000265148(uc003hxb.1 uc003hxc.1)

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      QuantiFast Probe-based Assays in human, mouse, rat CENPE

    Additional mRNA sequence: 

    AB209996.1 AK290362.1 AY429526.1 Z15005.1 

    6 DOTS entries:

    DT.95263628  DT.216504  DT.95263625  DT.91652562  DT.105417  DT.91667587 

    Selected AceView cDNA sequences (see all 109):

    AA210858 AA969619 BQ434767 N93653 AU131640 BQ447425 BX507434 AI807769 
    CR613861 AA210728 BE082268 BX952794 T28520 AL537570 CB160744 AA780024 
    AW499901 AL596934 BG122257 CK001045 AW470394 BX108887 AA694156 CF530046 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTAGCATA
    CENPE Expression
    About this image


    CENPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 4 entries
             Secondary Oocyte Antral Follicle
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus Progenitor Cells Choroid Plexus
             Lateral Ventricle
     
     Gonad
             Secondary Oocyte Antral Follicle
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             Pre-Sertoli Cells Testis Cord
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
    CENPE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75573
        Custom PCR Arrays for CENPE
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPE

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CENPE gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpe1 , 5 centromere protein E1, 5 73.88(n)1
    63.98(a)1
      3 (62.55 cM)5
    2298411  NM_173762.41  NP_776123.31 
     1352125635 
    chicken
    (Gallus gallus)
    Aves CENPE6
    centromere protein E, 312kDa
    44(a)
    1 ↔ 1
    4(60597388-60634806)
    African clawed frog
    (Xenopus laevis)
    Amphibia cenpe-A2 centromere protein E (kinesin-related protein) 76.91(n)    AF027728.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cenpe6
    centromere protein E
    28(a)
    1 ↔ 1
    1(134730-170748) ENSDARG00000063385
    fruit fly
    (Drosophila melanogaster)
    Insecta cmet3 microtubule-based movement kinetochore
    motor
    24(a)
    (best of 2)
      32E2   --
    rice
    (Oryza sativa)
    Liliopsida NM_188727.12   -- 82.44(n)    NM_188727.1 


    ENSEMBL Gene Tree for CENPE (if available)
    TreeFam Gene Tree for CENPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CENPE gene
    KIF4A2  KIF3A2  KIF5B2  KIF5C2  KIF21A2  KIF112  KIF3B2  KIF21B2  
    KIF172  KIF152  KIF5A2  KIF72  KIF4B2  KIF272  KIF3C2  
    15 SIMAP similar genes for CENPE using alignment to 3 protein entries:     CENPE_HUMAN (see all proteins):
    KIFC3    KIF5B    KIF23    KIF5C    KIF3A    KIF5A
    KIF27    KIF1C    KIF21A    KIF4A    KIF1A    KIF3B
    KIF6    KIF9    KIF13B

    Find genes that share paralogs with CENPE           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CENPE
    PGOHUM00000245639


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPE (see all 2012)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1151201921,2
    F--104026546(+) GAAGTC/TCATCC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs27204471,2
    C,F,H--104026547(+) AAGTCC/TATCCA 1 -- int120Minor allele frequency- T:0.12NA NS EA WA 2482
    rs1380318151,2
    --104026559(+) ATATGC/TTTTAT 1 -- int10--------
    rs1893059331,2
    --104026627(+) TTTCCC/TTATGT 1 -- int10--------
    rs1494972871,2
    C--104026720(+) AACCAA/CCCAAT 1 -- int10--------
    rs790862471,2
    F--104026872(+) CAGATC/ACAGAA 1 -- int11Minor allele frequency- A:0.01NA 120
    rs738376151,2
    C--104026963(+) AGAGCG/AGTGAT 1 -- ut312Minor allele frequency- A:0.19WA 120
    rs800351661,2
    C,F--104027080(+) GCTAAG/TTCATG 1 -- ut311Minor allele frequency- T:0.03WA 118
    rs757964311,2
    C,F--104027084(+) AGTCAT/CGTAGA 1 -- ut311Minor allele frequency- C:0.04WA 118
    rs1439819001,2
    C--104027246(+) TCTTTC/GAACTC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CENPE (104026963 - 104119566 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CENPE:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1606562CNV Deletion17803354
    esv2675893CNV Deletion23128226
    esv2728082CNV Deletion23290073
    nsv830021CNV Loss17160897
    esv2554056CNV Loss19546169
    nsv830022CNV Loss17160897
    dgv1656e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CENPE
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPE
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 117143    OMIM disorders: --


    Find genes that share disorders with CENPE           About GenesLikeMe

    2 Novoseek inferred disease relationships for CENPE gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 2 17431110 (1), 19779646 (1)
    cancer 0 2 20021663 (1), 17431110 (1)

    Genetic Association Database (GAD): CENPE
    Human Genome Epidemiology (HuGE) Navigator: CENPE (2 documents)

    Export disorders for CENPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPE gene, integrated from 10 sources (see all 155):
    (articles sorted by number of sources associating them with CENPE)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Defects in chromosome congression and mitotic progression in KIF18A- deficient cells are partly mediated through impaired functions of CENP-E. (PubMed id 19625775)1, 2, 9 Huang Y.... Dai W. (Cell Cycle 2009)
    2. Farnesyl transferase inhibitors block the farnesylation of CENP-E and CENP-F and alter the association of CENP-E with the microtubules. (PubMed id 10852915)1, 2, 9 Ashar H.R.... Kirschmeier P. (J. Biol. Chem. 2000)
    3. Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment. (PubMed id 17535814)1, 2, 9 Liu D.... Yao X. (J. Biol. Chem. 2007)
    4. Crystal structure of the motor domain of the human kinetochore protein CENP-E. (PubMed id 15236970)1, 2, 9 Garcia-Saez I.... Kozielski F. (J. Mol. Biol. 2004)
    5. CENP-E is a putative kinetochore motor that accumulates just before mitosis. (PubMed id 1406971)1, 2, 9 Yen T.J.... Cleveland D.W. (Nature 1992)
    6. Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor. (PubMed id 7889940)1, 2, 9 Thrower D.A.... Wilson L. (EMBO J. 1995)
    7. SUMO-2/3 modification and binding regulate the association of CENP-E with kinetochores and progression through mitosis. (PubMed id 18374647)1, 2, 9 Zhang X.-D....Matunis M.J. (Mol. Cell 2008)
    8. Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation. (PubMed id 15297875)1, 2, 9 Kurasawa Y.... Todokoro K. (EMBO J. 2004)
    9. CENP-E kinesin interacts with SKAP protein to orchestrate accurate chromosome segregation in mitosis. (PubMed id 22110139)1, 2 Huang Y....Yao X. (J. Biol. Chem. 2012)
    10. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PubMed id 20332099)1, 4 Kalsi G....Riley B.P. (Hum. Mol. Genet. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1062 HGNC: 1856 AceView: CENPE Ensembl:ENSG00000138778 euGenes: HUgn1062
    ECgene: CENPE H-InvDB: CENPE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPE Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CENPE Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPE gene:
    Search GeneIP for patents involving CENPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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