Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPC1 Gene

protein-coding   GIFtS: 57
GCID: GC04M068341

centromere protein C 1

 Explore 10 diseases affiliated with
CENPC1 via our new
 Human Malady Compendium 
Biological research products
for CENPC1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Centromere Protein C 11 2     Centromere Autoantigen C2 3
CENPC1 2 3 5     Interphase Centromere Complex Protein 72 3
CENP-C1 2     CENP-C 12 3
MIF21 2     Centromere Autoantigen C12
Hcp-41     ICEN73

External Ids:    HGNC: 18541   Entrez Gene: 10602   Ensembl: ENSG000001452417   OMIM: 1171415   UniProtKB: Q031883   

Export aliases for CENPC1 gene to outside databases

Previous GC identifers: GC04M068249 GC04M068166 GC04M068020 GC04M064251


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CENPC1:
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is
required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on
chromosome 12. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CENPC_HUMAN, Q03188
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly
of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD
(nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC
recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the
histone code in these regions

Gene Wiki entry for CENPC1


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_022778.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPC1 gene promoter:
         LHX3b/Lhx3b   Elk-1   HSF1 (long)   FOXD1   STAT5A   MEF-2A   S8   HSF1short   aMEF-2   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPC1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CENPC1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPC1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

CENPC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPC1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M068341:  view genomic region     (about GC identifiers)

Start:
68,337,521 bp from pter      End:
68,411,324 bp from pter
Size:
73,804 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CENPC_HUMAN, Q03188 (See protein sequence)
Recommended Name: Centromere protein C 1  
Size: 943 amino acids; 106834 Da
Subunit: Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT
and MLF1IP/CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO,
CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore
domain of centromeres
Secondary accessions: Q9P0M5

Explore the universe of human proteins at neXtProt for CENPC1: NX_Q03188

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q03188

  • CENPC1 Protein expression data from MOPED and PaxDb:    About this image 
    CENPC1 Protein Expression
    REFSEQ proteins: NP_001803.2  
    ENSEMBL proteins: 
     ENSP00000273853   ENSP00000421234   ENSP00000426078   ENSP00000425255  
    Reactome Protein details: Q03188
    Human Recombinant Protein Products for CENPC1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: CENPC1
    OriGene Custom Protein Services for CENPC1 
    GenScript Custom Purified and Recombinant Proteins Services for CENPC1
    Novus Biologicals CENPC1 Protein
    Novus Biologicals CENPC1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CENPC1

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA--
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000780condensed nuclear chromosome, centromeric region IDA11682612
    GO:0005634nucleus IDA--
    GO:0005721centromeric heterochromatin IDA--

    CENPC1 for ontologies           About GeneDecksing



    CENPC1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CENPC1 
    GenScript Custom Superior Antibodies Services for CENPC1
    Novus Biologicals CENPC1 Antibodies
    Abcam antibodies for CENPC1 
    Uscn Antibodies for CENPC1
    ThermoFisher Antibodies for CENPC1

    Assay Products for CENPC1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CENPC1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CENPC1


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CENPC1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR025974 Mif2/CENP-C_cupin
     IPR011051 RmlC_Cupin
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q03188

    ProtoNet protein and cluster: Q03188

    1 Blocks protein family: IPB013096 Cupin 2

    UniProtKB/Swiss-Prot: CENPC_HUMAN, Q03188
    Domain: The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology
    domain III can induce CENPC dimerization/oligomerization
    Similarity: Belongs to the CENPC family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPC_HUMAN, Q03188
    Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly
    of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD
    (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC
    recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the
    histone code in these regions

         Genatlas biochemistry entry for CENPC1:
    centromere protein C (140kDa),component of the inner kinetochore plate,1,associating specifically with DAXX during
    interphase,playing an essential role in centromere structureintegrity and microtubule attachment

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0005515protein binding ----
         
    CENPC1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CENPC1:
     Cell cycle / mitosis defect 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cenpc1):
     cellular  embryogenesis  growth/size  mortality/aging 

    CENPC1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CENPC1 

    miRNA
    Products:
        
    OriGene 3'-UTR Clone: CENPC1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CENPC1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CENPC1:
    hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidCENPC1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CENPC1 (see all 7)
    OriGene shRNA RFP: CENPC1
    OriGene siRNA: CENPC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CENPC1
    Sirion Biotech Custom design and validation of potent shRNA sequences against CENPC1 

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CENPC1
    Sirion Biotech Customized adenovirus for overexpression of CENPC1 
    Sirion Biotech Customized adenovirus for potent knockdown of CENPC1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPC1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CENPC1 (NM_001812)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPC1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CENPC1
    Search LifeMap BioReagents cell lines for CENPC1
    Sirion Biotech Customized stable knockdown cell line services for CENPC1 
    Sirion Biotech Customized inducible knockdown cell line services for CENPC1
    Sirion Biotech Customized stable overexpressing cell line services for CENPC1
    Sirion Biotech Customized inducible overexpressing cell line services for CENPC1

    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPC1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1M Phase
    M Phase1.00
    Mitotic Anaphase0.85
    Mitotic M-M/G1 phases0.88
    Separation of Sister Chromatids0.80
    Mitotic Metaphase and Anaphase0.85
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion1.00
    Mitotic Prometaphase0.93
    Kinetochore assembly0.96
    3Cell Cycle
    Cell Cycle1.00
    Cell Cycle, Mitotic0.84

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5/10        Reactome Pathways for CENPC1 (see all 10)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Mitotic Anaphase
    Cell Cycle



    CENPC1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CENPC1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/95 Interacting proteins for CENPC1 (Q031882, 3 ENSP000002738534) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAXXQ9UER73, ENSP000003968764I2D: score=3 STRING: ENSP00000396876 STRING: ENSP00000266000
    UBTFP174803, ENSP000003026404I2D: score=3 STRING: ENSP00000302640
    MIS12Q9H0813, ENSP000003705574I2D: score=2 STRING: ENSP00000370557
    PTENP604843, ENSP000003610214I2D: score=2 STRING: ENSP00000361021
    ZWINTO952293, ENSP000003630554I2D: score=2 STRING: ENSP00000363055
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000087M phase of mitotic cell cycle TAS--
    GO:0000236mitotic prometaphase TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IMP--
    GO:0051301cell division IEA--

    CENPC1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPC1
    Search CenterWatch for drugs/clinical trials and news about CENPC1 / CENPC 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CENPC1 gene: 
    NM_001812.2  

    Unigene Cluster for CENPC1:

    Centromere protein C 1
    Hs.479867  [show with all ESTs]
    Unigene Representative Sequence: BC030695
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273853(uc010ihj.1 uc003hdd.1) ENST00000513216 ENST00000506882(uc010ihk.1)
    ENST00000515140(uc010ihl.3) ENST00000510189(uc010ihm.1) ENST00000507196
    ENST00000506410

    miRNA
    Products:
         
    OriGene 3'-UTR Clone: CENPC1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CENPC1
    1 QIAGEN miScript miRNA Assays for microRNA that regulate CENPC1:
    hsa-miR-4282
    SwitchGear 3'UTR luciferase reporter plasmidCENPC1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CENPC1 (see all 7)
    OriGene shRNA RFP: CENPC1
    OriGene siRNA: CENPC1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CENPC1
    Sirion Biotech Custom design and validation of potent shRNA sequences against CENPC1 
    Clone
    Products:
         
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPC1 (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPC1 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CENPC1 (NM_001812)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPC1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPC1 
    Primer
    Products:
        
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CENPC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CENPC1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPC1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPC1

    Additional cDNA sequence: 

    AK307928.1 AK308170.1 AK308214.1 AK309437.1 BC030695.1 BC041117.1 BX648166.1 M95724.1 

    14 DOTS entries:

    DT.415041  DT.99992181  DT.40263990  DT.100026047  DT.100779434  DT.100779431  DT.100779437  DT.100779436 
    DT.102828346  DT.91759972  DT.92044642  DT.95268953  DT.40131588  DT.91831610 

    24/119 AceView cDNA sequences (see all 119):

    BU076088 BX390529 AA424080 BX444707 AU107427 AI675077 AA831354 AU100155 
    AA058734 BF591446 BU790236 BU790533 CA438224 BX390544 BU069070 BF195749 
    BE738325 AV753575 BG391491 BP348611 BI553314 BE737863 BX371968 BG031196 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CENPC1 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                          -                                                   
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CENPC1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CENPC1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    CENPC1 Expression
    About this image
    See CENPC1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CENPC1

    SOURCE GeneReport for Unigene cluster: Hs.479867
        SABiosciences Custom PCR Arrays for CENPC1

    Primer
    Products:
    OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CENPC1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CENPC1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPC1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPC1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPC1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CENPC1 gene from 3/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpc11 , 5 centromere protein C11, 5 69.74(n)1
    53.5(a)1
      5 (43.56 cM)5
    126171  NM_007683.31  NP_031709.21 
     860120435 
    chicken
    (Gallus gallus)
    Aves CENPC11 centromere protein C 1 46.33(n)
    32.25(a)
      395922  NM_205051.1  NP_990382.1 
    lizard
    (Anolis carolinensis)
    Reptilia CENPC16
    --
    40(a)
    1 ↔ 1
    6(58196235-58205171)


    ENSEMBL Gene Tree for CENPC1 (if available)
    TreeFam Gene Tree for CENPC1 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CENPC1 gene

    CENPC1 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CENPC1
    PGOHUM00000251024 PGOHUM00000251025


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1240 NCBI SNPs in CENPC1 are shown (see all 1240    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs581411221,2
    C--64255445(+) CCTGT-/TAAGTA 1 -- int12Minor allele frequency- T:0.00NA CSA 4
    rs1871003841,2
    --68337535(+) AAAAAA/GGGAAA 1 -- ds50010--------
    rs1920077981,2
    --68337568(+) AATGGC/TGAAGG 1 -- ds50010--------
    rs1158977051,2
    --68337581(+) ACTGCC/TTCCAA 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1833791091,2
    --68337692(+) GATAAC/TGCAAG 1 -- ds50010--------
    rs1867884821,2
    --68337793(+) TACAGA/GTTTTC 1 -- ds50010--------
    rs1902924691,2
    --68337809(+) CATCAA/CGGCCT 1 -- ds50010--------
    rs1825573111,2
    --68337941(+) CCTTTC/TACCAC 1 -- ds50010--------
    rs623031901,2
    C--68337975(+) AATAAT/AAAATG 1 -- ds50014Minor allele frequency- A:0.20NA WA EA 360
    rs76924961,2
    C,F,A,H--68338009(+) GATGTG/TTTTTA 1 -- ut31 ese315Minor allele frequency- T:0.29EA NA WA CSA 588

    HapMap Linkage Disequilibrium report for CENPC1 (68337521 - 68411324 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for CENPC1
         5 CNVs: 44167 98744 63849 63850 98743
         3 Indels: 92175 92176 80347

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPC1
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPC1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CENPC1 for disorders           About GeneDecksing

    OMIM gene information: 117141    OMIM disorders: --

    10 diseases for CENPC1:    About MalaCards
    y chromosome detection    limited scleroderma    connective tissue disease    sjogren's syndrome
    scleroderma    dyskinesia of esophagus    systemic scleroderma    multiple sclerosis
    osteosarcoma    breast cancer

    1 disease from the University of Copenhagen DISEASES database for CENPC1:
    Systemic scleroderma

    2 Novoseek disease relationships for CENPC1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 42 1 8187334 (1)
    sjogrens syndrome 21.3 1 15170924 (1)

    Human Genome Epidemiology (HuGE) Navigator: CENPC1 (1 document)

    Export disorders for CENPC1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CENPC1 gene, integrated from 9 sources (see all 124):
    (articles sorted by number of sources associating them with CENPC1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. (PubMed id 1339310)1, 2, 9 Saitoh H.... Earnshaw W.C. (1992)
    2. Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PubMed id 17651496)1, 2, 9 Alonso A....Warburton P.E. (2007)
    3. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 9 Foltz D.R....Cleveland D.W. (2006)
    4. The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation. (PubMed id 19503796)1, 2 Trazzi S.... Della Valle G. (2009)
    5. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. (PubMed id 19482874)1, 2 Gopalakrishnan S....Robertson K.D. (2009)
    6. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    8. Sequence homologies and linkage group conservation of the human and mouse Cenpc genes. (PubMed id 7959789)1, 3 McKay S....Cooke H. (1994)
    9. CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization. (PubMed id 14612452)1, 9 Suzuki N....Masumoto H. (2004)
    10. CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. (PubMed id 12006616)1, 9 Politi V....Della Valle G. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1060 HGNC: 1854 AceView: CENPC1 Ensembl:ENSG00000145241 euGenes: HUgn1060
    ECgene: CENPC1 H-InvDB: CENPC1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CENPC1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CENPC1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CENPC1 gene:
    Search GeneIP for patents involving CENPC1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for CENPC1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CENPC1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CENPC1  
     OriGene Protein Over-expression Lysate for CENPC1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CENPC1   OriGene 3'-UTR Clone for CENPC1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPC1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPC1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CENPC1   OriGene Custom Protein Services for CENPC1  
     OriGene Custom Immunoassay Development  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CENPC1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPC1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPC1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CENPC1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPC1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CENPC1
     GenScript Custom Purified and Recombinant Proteins Services for CENPC1 GenScript cDNA clones with any tag delivered in your preferred vector for CENPC1
     GenScript Custom Assay Services for CENPC1 GenScript Custom Superior Antibodies Services for CENPC1
     GenScript Custom overexpressing Cell Line Services for CENPC1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CENPC1 promoter
     Search Chromatin IP Primers for CENPC1
     RT2 qPCR Primer Assay in human, mouse, rat CENPC1
     GNC Network for CENPC1
     SABiosciences Custom PCR Arrays for CENPC1
     Search Tocris compounds for CENPC1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CENPC1 antibodies
     CENPC1 proteins
     CENPC1 lysates
     Antibodies for CENPC1
     See all of Abcam's Antibodies, Kits and Proteins for CENPC1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CENPC1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CENPC1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPC1
     SwitchGear 3'UTR luciferase reporter plasmids for CENPC1
     SwitchGear Promoter luciferase reporter plasmids for CENPC1
     ThermoFisher Antibodies for CENPC1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPC1
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CENPC1
    Sirion Biotech Customized:
     stable knockdown cell line services for CENPC1
     inducible knockdown cell line services for CENPC1
     design and validation of potent shRNA sequences against CENPC1
     adenovirus for potent knockdown of CENPC1
     adenovirus for overexpression of CENPC1
     stable overexpressing cell line services for CENPC1
     inducible overexpressing cell line services for CENPC1
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CENPC1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4