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CENPC Gene

protein-coding   GIFtS: 47
GCID: GC04M068337

Centromere Protein C

(Previous name: centromere protein C 1)
(Previous symbol: CENPC1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein C1 2     CENP-C 12 3
CENPC11 2 3 5     MIF22
Centromere Protein C 11 2 3     Centromere Autoantigen C12
Centromere Autoantigen C2 3     hcp-42
Interphase Centromere Complex Protein 72 3     ICEN73
CENP-C2 3     

External Ids:    HGNC: 18541   Entrez Gene: 10602   Ensembl: ENSG000001452417   OMIM: 1171415   UniProtKB: Q031883   

Export aliases for CENPC gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPC Gene:
Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is
required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene
exists on chromosome 12. (provided by RefSeq, Jul 2008)

GeneCards Summary for CENPC Gene:
CENPC (centromere protein C) is a protein-coding gene. Diseases associated with CENPC include y chromosome detection, and limited scleroderma.

UniProtKB/Swiss-Prot: CENPC_HUMAN, Q03188
Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats
and regulates the histone code in these regions

Gene Wiki entry for CENPC (CENPC1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for CENPC
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPC promoter sequence
   Search Chromatin IP Primers for CENPC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q13.2   Ensembl cytogenetic band:  4q13.2   HGNC cytogenetic band: 4q13.2

CENPC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPC gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M068337:  view genomic region     (about GC identifiers)

Start:
68,337,521 bp from pter      End:
68,411,324 bp from pter
Size:
73,804 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPC_HUMAN, Q03188 (See protein sequence)
Recommended Name: Centromere protein C  
Size: 943 amino acids; 106834 Da
Subunit: Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN,
CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL,
CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA
Secondary accessions: Q9P0M5

Explore the universe of human proteins at neXtProt for CENPC: NX_Q03188

Explore proteomics data for CENPC at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys10, Lys119, Lys507, Lys727, Lys746, Lys807, Lys871
  • Modification sites at PhosphoSitePlus

  • See CENPC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001803.2  
    ENSEMBL proteins: 
     ENSP00000273853   ENSP00000421234   ENSP00000426078   ENSP00000425255  
    Reactome Protein details: Q03188

    CENPC Human Recombinant Protein Products:

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    Novus Biologicals CENPC Protein
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    Cloud-Clone Corp. Proteins for CENPC

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR025974 Mif2/CENP-C_cupin
     IPR028052 CENP_C_N_dom
     IPR011051 RmlC_Cupin
     IPR028386 CENP-C/Mif2/cnp3
     IPR014710 RmlC-like_jellyroll

    Graphical View of Domain Structure for InterPro Entry Q03188

    ProtoNet protein and cluster: Q03188

    1 Blocks protein domain: IPB013096 Cupin 2

    UniProtKB/Swiss-Prot: CENPC_HUMAN, Q03188
    Domain: The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2
    homology domain III can induce CENPC dimerization/oligomerization
    Similarity: Belongs to the CENPC family


    CENPC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPC_HUMAN, Q03188
    Function: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in
    assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits
    the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into
    centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats
    and regulates the histone code in these regions

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS1339310
    GO:0005515protein binding ----
    GO:0019237centromeric DNA binding IEA--
         
    CENPC for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CENPC:
     Cell cycle / mitosis defect 

         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cenpc1):
     cellular  embryogenesis  growth/size/body  mortality/aging 

    CENPC for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPC
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    Sino Biological Human cDNA Clone for CENPC
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPC

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPC_HUMAN, Q03188: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore
    domain of centromeres

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000776kinetochore IDA--
    GO:0000777condensed chromosome kinetochore IEA--
    GO:0000780condensed nuclear chromosome, centromeric region IDA11682612
    GO:0005634nucleus IDA--
    GO:0005721centromeric heterochromatin IDA--

    CENPC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPC About    
    See pathways by source

    SuperPathContained pathways About
    1Mitotic Metaphase and Anaphase
    Mitotic Anaphase0.94
    Mitotic Metaphase and Anaphase0.93
    Separation of Sister Chromatids0.94
    2Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    M Phase0.62
    Cell Cycle0.90
    3Mitotic Prometaphase
    Mitotic Prometaphase0.92
    Resolution of Sister Chromatid Cohesion0.92

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    3 Reactome Pathways for CENPC
        Resolution of Sister Chromatid Cohesion
    Mitotic Prometaphase
    Separation of Sister Chromatids



    CENPC for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPC
    Interactions:

        Search GeneGlobe Interaction Network for CENPC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CENPC (Q031882, 3 ENSP000002738534) via UniProtKB, MINT, STRING, and/or I2D (see all 168)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206481Q146763, ENSP000003730604I2D: score=1 STRING: ENSP00000373060
    ENSG00000224587Q146763I2D: score=1 
    ENSG00000225589Q146763I2D: score=1 
    ENSG00000228575Q146763I2D: score=1 
    ENSG00000231135Q146763I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000278mitotic cell cycle TAS--
    GO:0007059chromosome segregation IMP--
    GO:0007067mitosis IEA--
    GO:0051382kinetochore assembly IMP--

    CENPC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPC



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CENPC gene: 
    NM_001812.2  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000273853(uc010ihj.1 uc003hdd.1) ENST00000513216 ENST00000506882(uc010ihk.1)
    ENST00000515140(uc010ihl.3) ENST00000510189(uc010ihm.1) ENST00000507196
    ENST00000506410
    miRNA
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    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPC
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CENPC
      QuantiFast Probe-based Assays in human, mouse, rat CENPC

    Selected AceView cDNA sequences (see all 119):

    BU790533 BF195749 BU069070 BX390529 AA058734 AA831354 AU107427 AA424080 
    BX390544 BF591446 BX444707 AI675077 AU100155 BU076088 BU790236 CA438224 
    BX115185 BE738325 BI553314 AA651868 BU662778 AW235142 BI907598 BC041117 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CENPC (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                          -                                                   
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for CENPC

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CENPC Expression
    About this image

    CENPC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPC Protein Expression
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CENPC gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpc11 , 5 centromere protein C11, 5 69.97(n)1
    53.84(a)1
      5 (43.56 cM)5
    126171  NM_007683.31  NP_031709.21 
     860120435 
    chicken
    (Gallus gallus)
    Aves CENPC16
    Gallus gallus centromere protein C 1 (CENPC1), mRN...
    24(a)
    1 ↔ 1
    4(50989146-51021153)
    lizard
    (Anolis carolinensis)
    Reptilia CENPC6
    centromere protein C
    42(a)
    1 ↔ 1
    6(58196235-58205171)


    ENSEMBL Gene Tree for CENPC (if available)
    TreeFam Gene Tree for CENPC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CENPC gene
    1 SIMAP similar gene for CENPC using alignment to 3 protein entries:     CENPC_HUMAN (see all proteins):
    CENPC1

    CENPC for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CENPC
    PGOHUM00000251024 PGOHUM00000251025


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPC (see all 1540)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871003841,2
    --68337535(+) AAAAAA/GGGAAA 1 -- ds50010--------
    rs1920077981,2
    --68337568(+) AATGGC/TGAAGG 1 -- ds50010--------
    rs1158977051,2
    C,F--68337581(+) ACTGCC/TTCCAA 1 -- ds50011Minor allele frequency- T:0.01NA 120
    rs1833791091,2
    --68337692(+) GATAAC/TGCAAG 1 -- ds50010--------
    rs1867884821,2
    C--68337793(+) TACAGA/GTTTTC 1 -- ds50010--------
    rs1902924691,2
    --68337809(+) CATCAA/CGGCCT 1 -- ds50010--------
    rs1825573111,2
    --68337941(+) CCTTTC/TACCAC 1 -- ds50010--------
    rs623031901,2
    C--68337975(+) AATAAT/AAAATG 1 -- ds50014Minor allele frequency- A:0.20NA WA EA 360
    rs76924961,2
    C,F,A,H--68338009(+) GATGTG/TTTTTA 1 -- ut31 ese315Minor allele frequency- T:0.29EA NA WA CSA 588
    rs1382722281,2
    --68338024(+) GTAGAC/GATATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CENPC (68337521 - 68411324 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CENPC: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPC
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 117141    OMIM disorders: --

    9 diseases for CENPC:    
    About MalaCards
    y chromosome detection    limited scleroderma    sjogren's syndrome    rheumatic disease
    connective tissue disease    scleroderma    osteosarcoma    multiple sclerosis
    breast cancer


    CENPC for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for CENPC gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 42 1 8187334 (1)
    sjogrens syndrome 21.3 1 15170924 (1)


    Export disorders for CENPC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPC gene, integrated from 10 sources (see all 126):
    (articles sorted by number of sources associating them with CENPC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. (PubMed id 1339310)1, 2, 9 Saitoh H.... Earnshaw W.C. (Cell 1992)
    2. Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PubMed id 17651496)1, 2, 9 Alonso A.... Warburton P.E. (Genome Biol. 2007)
    3. The human CENP-A centromeric nucleosome-associated complex. (PubMed id 16622419)1, 2, 9 Foltz D.R....Cleveland D.W. (Nat. Cell Biol. 2006)
    4. The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation. (PubMed id 19503796)1, 2 Trazzi S.... Della Valle G. (PLoS ONE 2009)
    5. DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions. (PubMed id 19482874)1, 2 Gopalakrishnan S....Robertson K.D. (Hum. Mol. Genet. 2009)
    6. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PubMed id 16716197)1, 2 Izuta H.... Yoda K. (Genes Cells 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Sequence homologies and linkage group conservation of the human and mouse Cenpc genes. (PubMed id 7959789)1, 3 McKay S....Cooke H. (Genomics 1994)
    9. CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization. (PubMed id 14612452)1, 9 Suzuki N....Masumoto H. (J. Biol. Chem. 2004)
    10. CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. (PubMed id 12006616)1, 9 Politi V....Della Valle G. (J. Cell. Sci. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Entrez Gene: 1060 HGNC: 1854 AceView: CENPC1 Ensembl:ENSG00000145241 euGenes: HUgn1060
    ECgene: CENPC H-InvDB: CENPC

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPC Pharmacogenomics, SNPs, Pathways

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