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Aliases for CENPC Gene

Aliases for CENPC Gene

  • Centromere Protein C 2 3 5
  • Centromere Protein C 1 2 3 4
  • Interphase Centromere Complex Protein 7 3 4
  • Centromere Autoantigen C 3 4
  • CENP-C 1 3 4
  • CENPC1 3 4
  • CENP-C 3 4
  • Centromere Autoantigen C1 3
  • Hcp-4 3
  • ICEN7 4
  • MIF2 3

External Ids for CENPC Gene

Previous HGNC Symbols for CENPC Gene

  • CENPC1

Previous GeneCards Identifiers for CENPC Gene

  • GC04M068337

Summaries for CENPC Gene

Entrez Gene Summary for CENPC Gene

  • Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPC Gene

CENPC (Centromere Protein C) is a Protein Coding gene. Diseases associated with CENPC include Limited Scleroderma and Connective Tissue Disease. Among its related pathways are Mitotic Metaphase and Anaphase and Cell Cycle, Mitotic. GO annotations related to this gene include centromeric DNA binding.

UniProtKB/Swiss-Prot for CENPC Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.

Gene Wiki entry for CENPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPC Gene

Genomics for CENPC Gene

Regulatory Elements for CENPC Gene

Enhancers for CENPC Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F067543 1.1 ENCODE 37.9 +0.5 474 2.8 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 CENPC UBA6 LOC101927237 STAP1 GCOM2 GC04M067379
GH04F067574 1.2 Ensembl ENCODE 34.4 -30.5 -30506 2.8 TBP NFRKB ZNF366 CBX5 ETV6 CREM BCLAF1 SMAD5 GTF2B ZEB2 CENPC UBA6 STAP1 LOC101927237 GC04P067584
GH04F068346 1.1 ENCODE 29.8 -803.2 -803189 5.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 CENPC UBA6 YTHDC1 ENSG00000270257 UGT2B29P TMPRSS11BNL APOOP4
GH04F067580 0.9 Ensembl ENCODE 24.6 -36.1 -36083 1.7 CBX5 ZBED1 IKZF1 CBFB JUNB ZHX2 DPF2 CREM RELA CENPC STAP1 LOC101927237 GC04P067584
GH04F067522 0.9 ENCODE 16.3 +22.5 22486 1.8 HDAC1 PKNOX1 ATF1 ARNT TBL1XR1 NFRKB CHAMP1 GATA2 CREM SMARCA5 LOC101927237 CENPC STAP1 GC04M067379
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPC on UCSC Golden Path with GeneCards custom track

Promoters for CENPC Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001242225 505 2600 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1

Genomic Location for CENPC Gene

Chromosome:
4
Start:
67,468,748 bp from pter
End:
67,545,606 bp from pter
Size:
76,859 bases
Orientation:
Minus strand

Genomic View for CENPC Gene

Genes around CENPC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPC Gene

Proteins for CENPC Gene

  • Protein details for CENPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03188-CENPC_HUMAN
    Recommended name:
    Centromere protein C
    Protein Accession:
    Q03188
    Secondary Accessions:
    • Q6PIR0
    • Q8IW27
    • Q9P0M5

    Protein attributes for CENPC Gene

    Size:
    943 amino acids
    Molecular mass:
    106834 Da
    Quaternary structure:
    • Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (PubMed:16622419). The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX (PubMed:9645950). Interacts with DNMT3B (PubMed:19482874). Interacts directly with CENPA (PubMed:19503796). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292). Interacts with MEIKIN (By similarity).

    Alternative splice isoforms for CENPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPC Gene

Post-translational modifications for CENPC Gene

  • Ubiquitination at Lys 10, Lys 119, Lys 507, Lys 727, Lys 746, Lys 807, and Lys 871
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPC Gene

No data available for DME Specific Peptides for CENPC Gene

Domains & Families for CENPC Gene

Suggested Antigen Peptide Sequences for CENPC Gene

Graphical View of Domain Structure for InterPro Entry

Q03188

UniProtKB/Swiss-Prot:

CENPC_HUMAN :
  • The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.
  • Belongs to the CENPC family.
Domain:
  • The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.
Family:
  • Belongs to the CENPC family.
genes like me logo Genes that share domains with CENPC: view

No data available for Gene Families for CENPC Gene

Function for CENPC Gene

Molecular function for CENPC Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.

Gene Ontology (GO) - Molecular Function for CENPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 1339310
GO:0019237 centromeric DNA binding IEA,IBA --
genes like me logo Genes that share ontologies with CENPC: view
genes like me logo Genes that share phenotypes with CENPC: view

Animal Models for CENPC Gene

MGI Knock Outs for CENPC:

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPC

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CENPC Gene

Localization for CENPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPC Gene

Nucleus. Chromosome, centromere, kinetochore. Chromosome, centromere. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000269 PubMed:21529714}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPC gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CENPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA,IDA 21529714
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000778 condensed nuclear chromosome kinetochore IBA --
GO:0000780 condensed nuclear chromosome, centromeric region IDA 11682612
genes like me logo Genes that share ontologies with CENPC: view

Pathways & Interactions for CENPC Gene

genes like me logo Genes that share pathways with CENPC: view

Gene Ontology (GO) - Biological Process for CENPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IMP 21529714
GO:0007049 cell cycle IEA --
GO:0007059 chromosome segregation IMP 21529714
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
genes like me logo Genes that share ontologies with CENPC: view

No data available for SIGNOR curated interactions for CENPC Gene

Transcripts for CENPC Gene

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CENPC

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for CENPC Gene

GeneLoc Exon Structure for
CENPC
ECgene alternative splicing isoforms for
CENPC

Expression for CENPC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CENPC Gene

Protein differential expression in normal tissues from HIPED for CENPC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.6), Skin (9.2), Blymphocyte (8.4), CD8 Tcells (7.0), and Testis (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPC Gene



Protein tissue co-expression partners for CENPC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CENPC Gene:

CENPC
genes like me logo Genes that share expression patterns with CENPC: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPC Gene

Orthologs for CENPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPC1 34 35
  • 99.58 (n)
cow
(Bos Taurus)
Mammalia CENPC1 34 35
  • 82.16 (n)
dog
(Canis familiaris)
Mammalia CENPC 34 35
  • 82.11 (n)
rat
(Rattus norvegicus)
Mammalia Cenpc 34
  • 72.52 (n)
mouse
(Mus musculus)
Mammalia Cenpc1 34 16 35
  • 69.97 (n)
oppossum
(Monodelphis domestica)
Mammalia CENPC 35
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPC 35
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPC1 35
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPC 35
  • 42 (a)
OneToOne
Species where no ortholog for CENPC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CENPC Gene

ENSEMBL:
Gene Tree for CENPC (if available)
TreeFam:
Gene Tree for CENPC (if available)

Paralogs for CENPC Gene

(1) SIMAP similar genes for CENPC Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CENPC Gene

genes like me logo Genes that share paralogs with CENPC: view

No data available for Paralogs for CENPC Gene

Variants for CENPC Gene

Sequence variations from dbSNP and Humsavar for CENPC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10002575 -- 67,483,283(+) aaccc(A/C/G)ggagg intron-variant
rs10003115 -- 67,520,510(+) CTCCA(C/T)CCAAT intron-variant
rs10003368 -- 67,521,343(+) acaaa(C/T)gaaaa intron-variant
rs10010704 -- 67,473,104(+) ttttt(C/T)ttttt intron-variant
rs10014035 -- 67,532,646(+) gcgag(G/T)acaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CENPC Gene

Variant ID Type Subtype PubMed ID
nsv950046 CNV duplication 24416366
esv3600851 CNV loss 21293372
esv3600850 CNV loss 21293372
esv2727765 CNV deletion 23290073
esv2674936 CNV deletion 23128226
esv2669747 CNV deletion 23128226
esv2605147 CNV deletion 19546169
esv2512052 CNV deletion 19546169
esv24989 CNV loss 19812545
esv2356691 CNV deletion 18987734
esv22504 CNV loss 19812545
dgv5241n100 CNV gain 25217958

Variation tolerance for CENPC Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.59; 44.95% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPC Gene

Disorders for CENPC Gene

MalaCards: The human disease database

(2) MalaCards diseases for CENPC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
limited scleroderma
  • crest syndrome
connective tissue disease
  • connective tissue disorder
- elite association - COSMIC cancer census association via MalaCards
Search CENPC in MalaCards View complete list of genes associated with diseases

Relevant External Links for CENPC

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPC
genes like me logo Genes that share disorders with CENPC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CENPC Gene

Publications for CENPC Gene

  1. Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PMID: 17651496) Alonso A. … Warburton P.E. (Genome Biol. 2007) 3 4 22 64
  2. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4 22 64
  3. Interphase-specific association of intrinsic centromere protein CENP- C with HDaxx, a death domain-binding protein implicated in Fas- mediated cell death. (PMID: 9645950) Pluta A.F. … Goldberg I.G. (J. Cell Sci. 1998) 3 4 22 64
  4. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. (PMID: 1339310) Saitoh H. … Earnshaw W.C. (Cell 1992) 3 4 22 64
  5. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes. (PMID: 21529714) Gascoigne K.E. … Cheeseman I.M. (Cell 2011) 3 4 64

Products for CENPC Gene

Sources for CENPC Gene

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