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Aliases for CENPC Gene

Aliases for CENPC Gene

  • Centromere Protein C 2 3
  • Centromere Protein C 1 2 3 4
  • Interphase Centromere Complex Protein 7 3 4
  • Centromere Autoantigen C 3 4
  • CENP-C 1 3 4
  • CENPC1 3 4
  • CENP-C 3 4
  • Centromere Autoantigen C1 3
  • CENPC1, 6
  • Hcp-4 3
  • ICEN7 4
  • MIF2 3

External Ids for CENPC Gene

Previous HGNC Symbols for CENPC Gene

  • CENPC1

Previous GeneCards Identifiers for CENPC Gene

  • GC04M068337

Summaries for CENPC Gene

Entrez Gene Summary for CENPC Gene

  • Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPC Gene

CENPC (Centromere Protein C) is a Protein Coding gene. Diseases associated with CENPC include limited scleroderma. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic.

UniProtKB/Swiss-Prot for CENPC Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.

Gene Wiki entry for CENPC Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPC Gene

Genomics for CENPC Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CENPC Gene

Start:
67,471,803 bp from pter
End:
67,545,606 bp from pter
Size:
73,804 bases
Orientation:
Minus strand

Genomic View for CENPC Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPC Gene

No data available for Regulatory Elements for CENPC Gene

Proteins for CENPC Gene

  • Protein details for CENPC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03188-CENPC_HUMAN
    Recommended name:
    Centromere protein C
    Protein Accession:
    Q03188
    Secondary Accessions:
    • Q6PIR0
    • Q8IW27
    • Q9P0M5

    Protein attributes for CENPC Gene

    Size:
    943 amino acids
    Molecular mass:
    106834 Da
    Quaternary structure:
    • Oligomer. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Binds to DAXX. Interacts directly with CENPA. Interacts with MEIKIN (By similarity).

    Alternative splice isoforms for CENPC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPC Gene

Proteomics data for CENPC Gene at MOPED

Post-translational modifications for CENPC Gene

  • Ubiquitination at Lys10, Lys119, Lys507, Lys727, Lys746, Lys807, and Lys871
  • Modification sites at PhosphoSitePlus

Other Protein References for CENPC Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPC Gene

Domains for CENPC Gene

Graphical View of Domain Structure for InterPro Entry

Q03188

UniProtKB/Swiss-Prot:

CENPC_HUMAN :
  • Q03188
Domain:
  • The MIF2 homology domain II targets centromeres and binds the alpha satellite DNA in vivo. The MIF2 homology domain III can induce CENPC dimerization/oligomerization.
Family:
  • Belongs to the CENPC family.
genes like me logo Genes that share domains with CENPC: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CENPC Gene

Function for CENPC Gene

Molecular function for CENPC Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPC recruits DNA methylation and DNMT3B to both centromeric and pericentromeric satellite repeats and regulates the histone code in these regions.

Gene Ontology (GO) - Molecular Function for CENPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 1339310
GO:0005515 protein binding --
GO:0019237 centromeric DNA binding IEA --
genes like me logo Genes that share ontologies with CENPC: view

Phenotypes for CENPC Gene

genes like me logo Genes that share phenotypes with CENPC: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPC

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CENPC Gene

Localization for CENPC Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPC Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. {ECO:0000269 PubMed:21529714}.

Gene Ontology (GO) - Cellular Components for CENPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IDA 21529714
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000780 condensed nuclear chromosome, centromeric region IDA 11682612
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with CENPC: view

No data available for Subcellular locations from COMPARTMENTS for CENPC Gene

Pathways for CENPC Gene

genes like me logo Genes that share pathways with CENPC: view

Pathways by source for CENPC Gene

Gene Ontology (GO) - Biological Process for CENPC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007059 chromosome segregation IMP 21529714
GO:0007067 mitotic nuclear division IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with CENPC: view

Transcripts for CENPC Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CENPC

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CENPC Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1:
SP2:
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for CENPC Gene

GeneLoc Exon Structure for
CENPC
ECgene alternative splicing isoforms for
CENPC

Expression for CENPC Gene

mRNA expression in normal human tissues for CENPC Gene

Protein differential expression in normal tissues for CENPC Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.6), Skin (9.2), Blymphocyte (8.4), CD8 Tcells (7.0), and Testis (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CENPC Gene

genes like me logo Genes that share expressions with CENPC: view

Expression partners for CENPC Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CENPC Gene

Orthologs for CENPC Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPC Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CENPC1 35
  • 82.16 (n)
  • 68.61 (a)
CENPC1 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CENPC 35
  • 82.11 (n)
  • 70.47 (a)
CENPC 36
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpc1 35
  • 69.97 (n)
  • 53.84 (a)
Cenpc1 16
Cenpc1 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CENPC1 35
  • 99.58 (n)
  • 99.15 (a)
CENPC1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpc 35
  • 72.52 (n)
  • 56.2 (a)
oppossum
(Monodelphis domestica)
Mammalia CENPC 36
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPC 36
  • 31 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPC1 36
  • 24 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPC 36
  • 42 (a)
OneToOne
Species with no ortholog for CENPC:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CENPC Gene

ENSEMBL:
Gene Tree for CENPC (if available)
TreeFam:
Gene Tree for CENPC (if available)

Paralogs for CENPC Gene

Selected SIMAP similar genes for CENPC Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for CENPC Gene

genes like me logo Genes that share paralogs with CENPC: view

No data available for Paralogs for CENPC Gene

Variants for CENPC Gene

Sequence variations from dbSNP and Humsavar for CENPC Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs11250 - 67,514,497(-) CACTC(C/T)TTCAA reference, missense, nc-transcript-variant
rs168538 -- 67,486,966(+) ctttt(A/G)ggttt intron-variant
rs173317 -- 67,515,649(-) ACAAC(A/G)TTTAT intron-variant
rs184804 -- 67,500,650(+) agtat(C/T)ataat intron-variant
rs187149 -- 67,491,446(+) TATTT(C/G)ATATA intron-variant

Relevant External Links for CENPC Gene

HapMap Linkage Disequilibrium report
CENPC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CENPC Gene

Disorders for CENPC Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CENPC Gene in MalaCards »

(1) Diseases for CENPC Gene including...

(2) Novoseek inferred disease relationships for CENPC Gene

Disease -log(P) Hits PubMed IDs
sclerosis systemic 42 1
sjogrens syndrome 21.3 1
genes like me logo Genes that share disorders with CENPC: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for CENPC Gene

Publications for CENPC Gene

  1. CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. (PMID: 1339310) Saitoh H. … Earnshaw W.C. (Cell 1992) 3 4 23
  2. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 3 4 23
  3. Co-localization of CENP-C and CENP-H to discontinuous domains of CENP-A chromatin at human neocentromeres. (PMID: 17651496) Alonso A. … Warburton P.E. (Genome Biol. 2007) 3 4 23
  4. Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. (PMID: 8702533) Pluta A.F. … Earnshaw W.C. (J. Biol. Chem. 1996) 3 23
  5. Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. (PMID: 17287400) Faragher A.J. … Cohen G.M. (Mol. Biol. Cell 2007) 3 23

Products for CENPC Gene

Sources for CENPC Gene

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