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CENPB Gene

protein-coding   GIFtS: 58
GCID: GC20M003764

Centromere Protein B, 80kDa

(Previous name: centromere protein B (80kD))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centromere Protein B, 80kDa1 2
CENP-B2 3
Centromere Protein B (80kD)1
Centromere Autoantigen B2
Major Centromere Autoantigen B2
Centromere Protein B3

External Ids:    HGNC: 18521   Entrez Gene: 10592   Ensembl: ENSG000001258177   OMIM: 1171405   UniProtKB: P071993   

Export aliases for CENPB gene to outside databases

Previous GC identifers: GC20M003752 GC20M003759 GC20M003712


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CENPB Gene:
This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein
that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding
motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds
a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an
important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes.
It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere
antibodies. (provided by RefSeq, Jul 2008)

GeneCards Summary for CENPB Gene:
CENPB (centromere protein B, 80kDa) is a protein-coding gene. Diseases associated with CENPB include raynaud disease, and limited scleroderma. GO annotations related to this gene include sequence-specific DNA binding and centromeric DNA binding. An important paralog of this gene is TIGD2.

UniProtKB/Swiss-Prot: CENPB_HUMAN, P07199
Function: Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of
alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order
structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes

Gene Wiki entry for CENPB (Centromere protein B) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000020.11  NC_018931.2  NT_011387.9  
Regulatory elements:
   Regulatory transcription factor binding sites in the CENPB gene promoter:
         GR   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPB promoter sequence
   Search Chromatin IP Primers for CENPB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CENPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20p13   Ensembl cytogenetic band:  20p13   HGNC cytogenetic band: 20p13

CENPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M003764:  view genomic region     (about GC identifiers)

Start:
3,764,498 bp from pter      End:
3,767,337 bp from pter
Size:
2,840 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CENPB_HUMAN, P07199 (See protein sequence)
Recommended Name: Major centromere autoantigen B  
Size: 599 amino acids; 65171 Da
Subunit: Antiparallel homodimer. Interacts with CENPT
3 PDB 3D structures from and Proteopedia for CENPB:
1BW6 (3D)        1HLV (3D)        1UFI (3D)    
Secondary accessions: Q96EI4

Explore the universe of human proteins at neXtProt for CENPB: NX_P07199

Explore proteomics data for CENPB at MOPED

Post-translational modifications: 

  • Poly-ADP-ribosylated by PARP1 (By similarity)1
  • N-terminally methylated by METTL11A/NTM1. Alpha-N-methylation is stimulated in response to extracellular stimuli,
    including increased cell density and heat shock, and seems to facilitate binding to CENP-B boxes. Chromatin-bound
    CENP-B is primarily trimethylated1
  • Ubiquitination2 at Lys266, Lys276, Lys334
  • Modification sites at PhosphoSitePlus

  • See CENPB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001801.1  
    ENSEMBL proteins: 
     ENSP00000369075  

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    CENPB Antibody Products:

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    CENPB Assay Products:

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    Cloud-Clone Corp. ELISAs for CENPB
    Cloud-Clone Corp. CLIAs for CENPB


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR006600 HTH_CenpB_DNA-bd_dom
     IPR015115 Centromere_CenpB_dimerisation
     IPR004875 DDE_SF_endonuclease_CENPB-like
     IPR009057 Homeodomain-like
     IPR007889 HTH_Psq

    Graphical View of Domain Structure for InterPro Entry P07199

    ProtoNet protein and cluster: P07199

    2 Blocks protein domains:
    IPB004875 CENP-B protein
    IPB006695 CENP-B


    UniProtKB/Swiss-Prot: CENPB_HUMAN, P07199
    Similarity: Contains 1 HTH CENPB-type DNA-binding domain
    Similarity: Contains 1 HTH psq-type DNA-binding domain


    CENPB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPB_HUMAN, P07199
    Function: Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of
    alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order
    structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes

         Genatlas biochemistry entry for CENPB:
    centromere protein B (80kDa),associated with most human centromeres,function unknown

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0003677DNA binding ----
    GO:0003682chromatin binding NAS1893793
    GO:0003696satellite DNA binding NAS1893793
    GO:0019237centromeric DNA binding IC11682612
         
    CENPB for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cenpb):
     cellular  endocrine/exocrine gland  growth/size/body  mortality/aging  normal 
     reproductive system 

    CENPB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CENPB: Cenpbtm1Gmay Cenpbtm1Khac Cenpbtm2Khac Cenpbtm1Rpe

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CENPB
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CENPB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CENPB

    miRNA
    Products:
        
    miRTarBase miRNAs that target CENPB:
    hsa-mir-149-5p (MIRT045539), hsa-mir-324-5p (MIRT043157), hsa-let-7b-5p (MIRT032351)

    Block miRNA regulation of human, mouse, rat CENPB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CENPB (see all 19):
    hsa-miR-485-5p hsa-miR-875-3p hsa-miR-3194-5p hsa-miR-4251 hsa-miR-181a-2* hsa-miR-218 hsa-miR-3150a-3p hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidCENPB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPB

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPB

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CENPB_HUMAN, P07199: Nucleus. Chromosome, centromere
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytoskeleton3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA11084331
    GO:0005634nucleus IDA--

    CENPB for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CENPB About    
    See pathways by source

    SuperPathContained pathways About
    1FOXM1 transcription factor network
    FOXM1 transcription factor network


    1 BioSystems Pathway for CENPB
        FOXM1 transcription factor network


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CENPB
    Interactions:

        GeneGlobe Interaction Network for CENPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 16)

    Selected Interacting proteins for CENPB (P071992, 3 ENSP000003690754) via UniProtKB, MINT, STRING, and/or I2D (see all 37)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253132 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253132 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253132 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253132 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253132 I2D: score=2 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated IEA--

    CENPB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CENPB

    2 Novoseek inferred chemical compound relationships for CENPB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oligonucleotide 20.8 5 2071944 (1), 9543016 (1), 8198697 (1), 1730770 (1)
    hydroxyurea 11.9 1 11129795 (1)



    CENPB for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CENPB gene: 
    NM_001810.5  

    Unigene Cluster for CENPB:

    Centromere protein B, 80kDa
    Hs.516855  [show with all ESTs]
    Unigene Representative Sequence: NM_001810
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000379751(uc002wjk.3)
    miRNA
    Products:
         
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    Selected qRT-PCR Assays for microRNAs that regulate CENPB (see all 19):
    hsa-miR-485-5p hsa-miR-875-3p hsa-miR-3194-5p hsa-miR-4251 hsa-miR-181a-2* hsa-miR-218 hsa-miR-3150a-3p hsa-miR-129-3p
    SwitchGear 3'UTR luciferase reporter plasmidCENPB 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CENPB
    Clone
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    OriGene clones in human, mouse for CENPB (see all 6)
    OriGene ORF clones in mouse, rat for CENPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CENPB (NM_001810)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPB
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CENPB
      QuantiTect SYBR Green Assays in human, mouse, rat CENPB
      QuantiFast Probe-based Assays in human, mouse, rat CENPB

    Additional mRNA sequence: 

    BC003649.2 BC012297.1 BC021577.1 BC033658.1 BC040446.2 BC053847.1 X05299.1 

    8 DOTS entries:

    DT.413828  DT.95204579  DT.97847829  DT.97847830  DT.102825597  DT.92440831  DT.95204578  DT.95204582 

    Selected AceView cDNA sequences (see all 244):

    AW189143 BE792481 AW246638 BU627772 BU541735 BQ025796 BU859567 BU170013 
    CK724874 BU741283 AI972471 BC012297 BU632090 BU680725 CR591718 BQ008449 
    BE622329 AW016854 BQ954415 AI241567 BQ053301 BQ014171 BM716657 AI471730 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CENPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTCTCCTCC
    CENPB Expression
    About this image


    CENPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
    CENPB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CENPB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516855
        Custom PCR Arrays for CENPB
    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CENPB gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpb1 , 5 centromere protein B1, 5 87.09(n)1
    89.98(a)1
      2 (63.29 cM)5
    126161  NM_007682.21  NP_031708.21 
     1311751825 


    ENSEMBL Gene Tree for CENPB (if available)
    TreeFam Gene Tree for CENPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CENPB gene
    TIGD22  TIGD12  TIGD62  TIGD42  TIGD72  JRKL2  TIGD52  TIGD32  
    1 SIMAP similar gene for CENPB using alignment to 1 protein entry:     CENPB_HUMAN:
    TIGD6

    CENPB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CENPB (see all 105)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1899989571,2
    --3713108(+) TCTTTC/TTCTTT 1 -- int10--------
    rs1402818371,2
    --3764153(+) CAAAGA/GTAAAC 1 -- ds50010--------
    rs454437921,2
    C--3764246(+) CCACTC/TCTGCA 1 -- ds50012Minor allele frequency- T:0.04NA 122
    rs1911372771,2
    --3764289(+) CCCCAC/TGTGCA 1 -- ds50010--------
    rs776188581,2
    F--3764467(+) AGACAG/CACGCA 1 -- ds50011Minor allele frequency- C:0.03WA 118
    rs1840262141,2
    --3764540(+) GGACAA/GATTTA 1 -- ut310--------
    rs1142622061,2
    C,F--3764592(+) CTGGGC/ACCAGC 1 -- ut311Minor allele frequency- A:0.02WA 118
    rs1503621441,2
    --3764650(+) GGCATA/GGGGCC 1 -- ut310--------
    rs61160381,2
    C,H--3764655(+) GGGGCC/TTGCAG 1 -- ut31 ese34Minor allele frequency- T:0.00NS EA 418
    rs10513681,2
    C,F--3764761(-) TCTGGC/TCCTGT 1 -- ut312Minor allele frequency- T:0.02MN NA 304

    HapMap Linkage Disequilibrium report for CENPB (3764498 - 3767337 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CENPB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912617CNV Loss21882294
    nsv912618CNV Loss21882294
    nsv833899CNV Loss17160897
    dgv4522n71CNV Loss21882294
    nsv912621CNV Loss21882294
    nsv828673CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPB
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 117140    OMIM disorders: --

    Selected diseases for CENPB (see all 25):    
    About MalaCards
    raynaud disease    limited scleroderma    telangiectasis    systemic scleroderma
    calcinosis    connective tissue disease    scleroderma    mixed connective tissue disease
    primary biliary cirrhosis    sjogren's syndrome    non-hodgkin lymphoma    hodgkin's lymphoma
    rheumatic disease    lupus erythematosus    rheumatoid arthritis    herpes simplex
    systemic lupus erythematosus    arthritis    esophagitis    ataxia

    4 diseases from the University of Copenhagen DISEASES database for CENPB:
    Systemic scleroderma     Raynaud disease     Telangiectasis     Calcinosis

    CENPB for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CENPB gene (see all 20)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerodactyly 79.1 1 8129780 (1)
    crest syndrome 75.4 2 8198697 (1)
    raynauds phenomenon 67.9 1 8129780 (1)
    sclerosis systemic 66.2 7 8187334 (1), 19714638 (1), 10648030 (1), 16014550 (1) (see all 6)
    calcinosis 63.4 1 8129780 (1)
    telangiectasia 56.7 1 8129780 (1)
    raynauds syndrome 52.6 1 8129780 (1)
    connective tissue diseases 51.9 1 8129780 (1)
    esophageal motility disorders 51.6 1 8129780 (1)
    biliary cirrhosis primary 44.7 1 8527711 (1)


    Export disorders for CENPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CENPB gene, integrated from 10 sources (see all 164):
    (articles sorted by number of sources associating them with CENPB)
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    1. A human centromere protein, CENP-B, has a DNA binding domain containing four potential alpha helices at the NH2 terminus, which is separable from dimerizing activity. (PubMed id 1469042)1, 2, 9 Yoda K.... Okazaki T. (J. Cell Biol. 1992)
    2. CENP-B is a highly conserved mammalian centromere protein with homology to the helix-loop-helix family of proteins. (PubMed id 1893793)1, 2, 9 Sullivan K.F. and Glass C.A. (Chromosoma 1991)
    3. Crystal structure of the human centromere protein B (CENP-B) dimerization domain at 1.65-A resolution. (PubMed id 14522975)1, 2, 9 Tawaramoto M.S....Yokoyama S. (J. Biol. Chem. 2003)
    4. A helix-turn-helix structure unit in human centromere protein B (CENP-B). (PubMed id 9451007)1, 2, 9 Iwahara J....Yokoyama S. (EMBO J. 1998)
    5. CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells. (PubMed id 11884609)1, 3, 9 Ando S....Yoda K. (Mol. Cell. Biol. 2002)
    6. Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. (PubMed id 18072184)1, 2, 9 Orthaus S.... Diekmann S. (ChemBioChem 2008)
    7. Live-cell imaging reveals sustained centromere binding of CENP-T via CENP-A and CENP-B. (PubMed id 19412974)1, 2, 9 Hellwig D....Diekmann S. (J. Biophotonics 2008)
    8. Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure. (PubMed id 8406460)1, 3, 9 Sugimoto K....Himeno M. (Genomics 1993)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (Nature 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1059 HGNC: 1852 AceView: CENPB Ensembl:ENSG00000125817 euGenes: HUgn1059
    ECgene: CENPB H-InvDB: CENPB

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CENPB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CENPB gene:
    Search GeneIP for patents involving CENPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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