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Aliases for CENPA Gene

Aliases for CENPA Gene

  • Centromere Protein A 2 3 4
  • Histone H3-Like Centromeric Protein A 2 3
  • Centromere-Specific Histone 2 3
  • Centromere Protein A, 17kDa 2 3
  • Centromere Autoantigen A 3 4
  • CENP-A 3 4
  • Centromere Protein A (17kD) 2
  • CenH3 3

External Ids for CENPA Gene

Summaries for CENPA Gene

Entrez Gene Summary for CENPA Gene

  • Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for CENPA Gene

CENPA (Centromere Protein A) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Cell Cycle, Mitotic. GO annotations related to this gene include protein heterodimerization activity and chromatin binding.

UniProtKB/Swiss-Prot for CENPA Gene

  • Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).

Gene Wiki entry for CENPA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPA Gene

Genomics for CENPA Gene

Genomic Location for CENPA Gene

Start:
26,764,289 bp from pter
End:
26,801,067 bp from pter
Size:
36,779 bases
Orientation:
Plus strand

Genomic View for CENPA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CENPA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPA Gene

Regulatory Elements for CENPA Gene

Proteins for CENPA Gene

  • Protein details for CENPA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49450-CENPA_HUMAN
    Recommended name:
    Histone H3-like centromeric protein A
    Protein Accession:
    P49450
    Secondary Accessions:
    • D6W544
    • Q53T74
    • Q9BVW2

    Protein attributes for CENPA Gene

    Size:
    140 amino acids
    Molecular mass:
    15991 Da
    Quaternary structure:
    • Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more rigid than corresponding H3-H4 heterotetramers. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts (via CATD domain) with HJURP; the interaction is direct and is required for its localization to centromeres. Interacts with CENPC, CENPN and CENPT; interaction is direct. Interacts directly with herpes virus HSV-1 ICP0 protein. Part of a centromere complex consisting of CENPA, CENPT and CENPW.
    Miscellaneous:
    • Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed autoantibodies against centrosomal proteins

    Three dimensional structures from OCA and Proteopedia for CENPA Gene

    Alternative splice isoforms for CENPA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPA Gene

Proteomics data for CENPA Gene at MOPED

Post-translational modifications for CENPA Gene

  • Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by AURKA and is maintained by AURKB.
  • Poly-ADP-ribosylated by PARP1.
  • Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CENPA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CENPA Gene

Domains for CENPA Gene

Protein Domains for CENPA Gene

UniProtKB/Swiss-Prot:

CENPA_HUMAN
Domain:
  • The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes containing CENPA and is necessary and sufficient to mediate the localization into centromeres.:
    • P49450
Family:
  • Belongs to the histone H3 family.:
    • P49450
genes like me logo Genes that share domains with CENPA: view

No data available for Gene Families for CENPA Gene

Function for CENPA Gene

Molecular function for CENPA Gene

GENATLAS Biochemistry: centromeric protein A,histone H3 related,likely replaying H3 to form a centromere unique nucleosomal structure
UniProtKB/Swiss-Prot Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro).

Gene Ontology (GO) - Molecular Function for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding TAS 7962047
GO:0005515 protein binding IPI 19410544
GO:0046982 protein heterodimerization activity IEA --
genes like me logo Genes that share ontologies with CENPA: view
genes like me logo Genes that share phenotypes with CENPA: view

miRNA for CENPA Gene

miRTarBase miRNAs that target CENPA

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CENPA Gene

Localization for CENPA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPA Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the length of the constriction but encompassing only one third of the constriction width and height.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CENPA Gene COMPARTMENTS Subcellular localization image for CENPA gene
Compartment Confidence
nucleus 5
cytosol 4
cytoskeleton 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000775 chromosome, centromeric region IDA 11084331
GO:0000778 condensed nuclear chromosome kinetochore IDA 18195732
GO:0000780 condensed nuclear chromosome, centromeric region IDA 11682612
GO:0000786 nucleosome IEA --
GO:0000939 condensed chromosome inner kinetochore IEA --
genes like me logo Genes that share ontologies with CENPA: view

Pathways for CENPA Gene

genes like me logo Genes that share pathways with CENPA: view

Pathways by source for CENPA Gene

Gene Ontology (GO) - Biological Process for CENPA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IMP 19468067
GO:0000278 mitotic cell cycle TAS --
GO:0006334 nucleosome assembly TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with CENPA: view

Compounds for CENPA Gene

(2) Novoseek inferred chemical compound relationships for CENPA Gene

Compound -log(P) Hits PubMed IDs
hydrogen 0 1
glycerol 0 1
genes like me logo Genes that share compounds with CENPA: view

Transcripts for CENPA Gene

Unigene Clusters for CENPA Gene

Centromere protein A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPA Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
SP1:
SP2:
SP3: -
SP4: -
SP5: -
SP6: - - - - - - - - - - -
SP7: - - -

Relevant External Links for CENPA Gene

GeneLoc Exon Structure for
CENPA
ECgene alternative splicing isoforms for
CENPA

Expression for CENPA Gene

mRNA expression in normal human tissues for CENPA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CENPA Gene

SOURCE GeneReport for Unigene cluster for CENPA Gene Hs.1594

genes like me logo Genes that share expressions with CENPA: view

Orthologs for CENPA Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CENPA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPA 36
  • 97.34 (n)
  • 98.55 (a)
CENPA 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 50 (a)
OneToMany
-- 37
  • 80 (a)
OneToMany
-- 37
  • 68 (a)
OneToMany
-- 37
  • 74 (a)
OneToMany
CENPA 36
  • 82.13 (n)
  • 78.99 (a)
dog
(Canis familiaris)
Mammalia CENPA 36
  • 84.2 (n)
  • 79.26 (a)
CENPA 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cenpa 36
  • 72.09 (n)
  • 77.52 (a)
Cenpa 16
Cenpa 37
  • 63 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPA 37
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPA 37
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cenpa 36
  • 81.52 (n)
  • 81.19 (a)
chicken
(Gallus gallus)
Aves CENPA 36
  • 61.29 (n)
  • 62.9 (a)
CENPA 37
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CENPA 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpa 36
  • 62.37 (n)
  • 67.74 (a)
zebrafish
(Danio rerio)
Actinopterygii seph 37
  • 52 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cpar-1 37
  • 20 (a)
OneToMany
F20D6.9 37
  • 33 (a)
OneToMany
hcp-3 37
  • 19 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CSE4 37
  • 25 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3908 37
  • 32 (a)
OneToOne
Species with no ortholog for CENPA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CENPA Gene

ENSEMBL:
Gene Tree for CENPA (if available)
TreeFam:
Gene Tree for CENPA (if available)

Paralogs for CENPA Gene

genes like me logo Genes that share paralogs with CENPA: view

No data available for Paralogs for CENPA Gene

Variants for CENPA Gene

Sequence variations from dbSNP and Humsavar for CENPA Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1007357 -- 26,791,182(+) TGCTT(A/G)GCTCA intron-variant
rs1975213 -- 26,791,402(+) ATTAG(A/T)GAATT intron-variant
rs2117274 -- 26,791,310(+) ATTTC(C/T)AAATA intron-variant
rs2164043 -- 26,791,029(+) TCAGA(C/T)GTTCA intron-variant
rs2196151 -- 26,789,626(+) ACTCC(C/T)CTCCA intron-variant

Relevant External Links for CENPA Gene

HapMap Linkage Disequilibrium report
CENPA

No data available for Structural Variations from Database of Genomic Variants (DGV) for CENPA Gene

Disorders for CENPA Gene

(8) Novoseek inferred disease relationships for CENPA Gene

Disease -log(P) Hits PubMed IDs
sclerosis systemic 40.2 3
rheumatic diseases 30.6 1
autoimmune diseases 21.3 1
autoimmune response 18.8 1
tumors 1.65 2
genes like me logo Genes that share disorders with CENPA: view

No data available for UniProtKB/Swiss-Prot for CENPA Gene

Publications for CENPA Gene

  1. Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. (PMID: 7962047) Sullivan K.F. … Masri K. (J. Cell Biol. 1994) 3 4 23
  2. Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. (PMID: 9024683) Shelby R.D. … Sullivan K.F. (J. Cell Biol. 1997) 3 4 23
  3. Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3. (PMID: 10759786) Muro Y. … Sugimoto K. (Clin. Exp. Immunol. 2000) 3 4 23
  4. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. (PMID: 11756469) Zeitlin S.G. … Sullivan K.F. (J. Cell Biol. 2001) 3 4 23
  5. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. (PMID: 14667408) Kunitoku N. … Hirota T. (Dev. Cell 2003) 3 4 23

Products for CENPA Gene

  • Addgene plasmids for CENPA

Sources for CENPA Gene

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