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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CENPA Gene

protein-coding GIFtS: 62
GCID: GC02P026988

centromere protein A

(Previous names: centromere protein A (17kD), centromere protein A, 17kDa...)

Explore 15 diseases affiliated with
CENPA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Centromere Protein A¹ ² ³		Centromere Autoantigen A² ³
CENP-A¹ ² ³		Centromere Protein A (17kD)¹
CenH3¹ ²		Centromere-Specific Histone²
Centromere Protein A, 17kDa¹ ²		Histone H3-Like Centromeric Protein A²

External Ids:	HGNC: 1851¹	Entrez Gene: 1058²	Ensembl: ENSG00000115163⁷	OMIM: 117139⁵	UniProtKB: P49450³

Export aliases for CENPA gene to outside databases

Previous GC identifers: GC02P026908 GC02P027080 GC02P026962 GC02P026963 GC02P026898 GC02P026920 GC02P026750

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CENPA:

Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes

a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the

centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it

replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.

Alternative splicing results in multiple transcript variants encoding distinct isoforms. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: CENPA_HUMAN, P49450

Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric

chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins,

mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity

through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro)

Gene Wiki entry for CENPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CENPA gene promoter:
TBP Sp1 TFIID FOXJ2 (long isoform) FOXJ2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CENPA promoter sequence

Search SABiosciences Chromatin IP Primers for CENPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3

CENPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPA gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P026988: view genomic region (about GC identifiers)

Start:	26,987,157 bp from pter	End:	27,023,935 bp from pter
Size:	36,779 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CENPA_HUMAN, P49450 (See protein sequence)

Recommended Name: Histone H3-like centromeric protein A

Size: 140 amino acids; 15991 Da

Subunit: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled in

one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone H2A

variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally more

rigid than corresponding H3-H4 heterotetramers. Heterotrimer composed of HJURP, CENPA and histone H4, where HJURP

interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4. Component of the

CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and MLF1IP/CENPU. Interacts (via CATD

domain) with HJURP; the interaction is direct and is required for its localization to centromeres. Interacts with

CENPC, CENPN and CENPT; interaction is direct. Interacts directly with herpes virus HSV-1 ICP0 protein. Part of a

centromere complex consisting of CENPA, CENPT and CENPW

Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore

domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the

length of the constriction but encompassing only one third of the constriction width and height

Miscellaneous: Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed

autoantibodies against centrosomal proteins

4 PDB 3D structures from and Proteopedia for CENPA:

3AN2 (3D)

3NQJ (3D)

3NQU (3D)

3R45 (3D)

Secondary accessions: D6W544 Q53T74 Q9BVW2

Alternative splicing: 2 isoforms: P49450-1 P49450-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CENPA: NX_P49450

Post-translational modifications:

Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the proteasome

pathway¹

Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at inner

centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated by AURKA and

is maintained by AURKB¹

Poly-ADP-ribosylated by PARP1 (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49450

CENPA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001035891.1 NP_001800.1

ENSEMBL proteins:

ENSP00000336868 ENSP00000233505 ENSP00000404963

Reactome Protein details: P49450
Human Recombinant Protein Products for CENPA:

	EMD Millipore Purified and/or Recombinant CENPA Protein
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	Novus Biologicals CENPA Protein Novus Biologicals CENPA Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CENPA
	Uscn Proteins for CENPA

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000775	chromosome, centromeric region	IDA	11084331
GO:0000778	condensed nuclear chromosome kinetochore	IDA	18195732
GO:0000780	condensed nuclear chromosome, centromeric region	IDA	11682612
GO:0000786	nucleosome	IEA	--
GO:0000939	condensed chromosome inner kinetochore	IEA	--

CENPA for ontologies About GeneDecksing

CENPA Antibody Products:

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	ThermoFisher Antibodies for CENPA

Assay Products for CENPA:

	Browse Kits and Assays available from EMD Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CENPA
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CENPA

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CENPA for domains About GeneDecksing

3 InterPro domains/families:

IPR000164 Histone_H3

IPR009072 Histone-fold

IPR007125 Histone_core_D

Graphical View of Domain Structure for InterPro Entry P49450

ProtoNet protein and cluster: P49450

1 Blocks protein family: IPB000164 Histone H3

UniProtKB/Swiss-Prot: CENPA_HUMAN, P49450

Domain: The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes

containing CENPA and is necessary and sufficient to mediate the localization into centromeres

Similarity: Belongs to the histone H3 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CENPA_HUMAN, P49450

Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric

chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins,

mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity

through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro)

Genatlas biochemistry entry for CENPA:

centromeric protein A,histone H3 related,likely replaying H3 to form a centromere unique nucleosomal structure

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	TAS	7962047
GO:0005515	protein binding	IPI	--
GO:0046982	protein heterodimerization activity	IEA	--

CENPA for ontologies About GeneDecksing

Phenotypes:
3 GenomeRNAi human phenotypes for CENPA:

Decreased POU5F1-GFP protein e

Decreased viability of wild-ty

Upregulation of Wnt/beta-caten

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cenpa):

cardiovascular system	cellular	craniofacial	embryogenesis	growth/size
mortality/aging	nervous system

CENPA for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CENPA

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CENPA
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CENPA:
		hsa-miR-548n hsa-miR-3647-3p hsa-miR-3916 hsa-miR-3125
		SwitchGear 3'UTR luciferase reporter plasmid: CENPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CENPA

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CENPA
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		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CENPA (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CENPA (see all 3) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): CENPA (NM_001809)
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		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CENPA
		Search LifeMap BioReagents cell lines for CENPA
		Sirion Biotech Customized stable knockdown cell line services for CENPA Sirion Biotech Customized inducible knockdown cell line services for CENPA Sirion Biotech Customized stable overexpressing cell line services for CENPA Sirion Biotech Customized inducible overexpressing cell line services for CENPA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/10 super-pathways (see all 10) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

M Phase

M Phase	1.00	Mitotic Anaphase	0.85
Mitotic M-M/G1 phases	0.88	Separation of Sister Chromatids	0.80
Mitotic Metaphase and Anaphase	0.85

RSF Complex Binds the Centromere.

	RSF Complex Binds the Centromere.	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere	1.00
	Nucleosome assembly	1.00			Deposition of New CENPA-containing Nucleosomes at the Centromere.	0.96

Resolution of Sister Chromatid Cohesion

	Resolution of Sister Chromatid Cohesion	1.00			Mitotic Prometaphase	0.93
	Kinetochore assembly	0.96

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Chromatin Regulation / Acetylation

Chromatin Regulation / Acetylation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for CENPA

	Chromatin Regulation / Acetylation
	Cell Cycle / Checkpoint Control

3 BioSystems Pathways for CENPA

	Aurora B signaling
	Aurora A signaling
	FOXM1 transcription factor network

5/15 Reactome Pathways for CENPA (see all 15)

	Mitotic Metaphase and Anaphase
	Mitotic Prometaphase
	Resolution of Sister Chromatid Cohesion
	Nucleosome assembly
	Mitotic Anaphase

CENPA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CENPA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/162 Interacting proteins for CENPA (P49450^{1, 2, 3} ENSP00000336868⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 162)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4B	P62805¹^,³, ENSP00000366581⁴	EBI-1751979,EBI-302023 I2D: score=3 STRING: ENSP00000366581
HIST1H4C	P62805¹^,³	EBI-1751979,EBI-302023 I2D: score=3
HIST1H4D	P62805¹^,³	EBI-1751979,EBI-302023 I2D: score=3
HIST1H4E	P62805¹^,³	EBI-1751979,EBI-302023 I2D: score=3
HIST1H4F	P62805¹^,³	EBI-1751979,EBI-302023 I2D: score=3

About this table

Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000087	M phase of mitotic cell cycle	TAS	--
GO:0000132	establishment of mitotic spindle orientation	IMP	19468067
GO:0000236	mitotic prometaphase	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0006334	nucleosome assembly	TAS	--

CENPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CENPA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CENPA
2 Novoseek chemical compound relationships for CENPA gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
hydrogen	0	1	15282608 (1)
glycerol	0	1	10840064 (1)

Search CenterWatch for drugs/clinical trials and news about CENPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CENPA gene (2 alternative transcripts):

NM_001042426.1 NM_001809.3

Unigene Cluster for CENPA:

Centromere protein A

Hs.1594 [show with all ESTs]

Unigene Representative Sequence: BM911202

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000475662 ENST00000335756(uc002rhr.3 uc002rhs.3) ENST00000472719

ENST00000233505 ENST00000419525 ENST00000460030(uc002rht.3)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CENPA
		4 QIAGEN miScript miRNA Assays for microRNAs that regulate CENPA:
		hsa-miR-548n hsa-miR-3647-3p hsa-miR-3916 hsa-miR-3125
		SwitchGear 3'UTR luciferase reporter plasmid: CENPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CENPA

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		GenScript: all cDNA clones in your preferred vector (see all 2): CENPA (NM_001809)
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPA

Additional cDNA sequence:

BC000881.1 BC002703.2 BC011013.1 BT007246.1 U14518.1

4 DOTS entries:

DT.313100 DT.100748001 DT.91749874 DT.95162633

24/235 AceView cDNA sequences (see all 235):

AA554281 AI015703 AW235145 R59942 AA400455 BM834703 BQ009148 AI088374

BM677286 BF514720 BM719753 AI263576 BC035519 BM790060 BC028081 CR623149

CD628725 BM684110 BF982268 BU625516 AI611022 AA742587 BQ945655 AY358820

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CENPA (see all 7) About this scheme

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5	^	6a	·	6b	·	6c	·	6d	^	7a	·	7b	^	8	^	9	^	10	^	11
SP1:
SP2:
SP3:					-
SP4:							-
SP5:																											-

ECgene alternative splicing isoforms for CENPA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CENPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAACTGAGTG

About this image

CENPA expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Antral Follicle

Secondary Oocyte

Female Gametocytes, Germ Cells

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ progenitor E68 (Embryonic Progenitor Cell)

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

See CENPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CENPA

SOURCE GeneReport for Unigene cluster: Hs.1594

SABiosciences Custom PCR Arrays for CENPA

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CENPA Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CENPA
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CENPA gene from 8/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CENPA¹	centromere protein A	60.43(n) 62.6(a)		100113359 NM_001101037.1 NP_001094507.1
lizard (Anolis carolinensis)	Reptilia	CENPA⁶	--	70(a)	1 ↔ 1	2(198063842-198070803)
tropical clawed frog (Xenopus tropicalis)	Amphibia	141993012²	--	67.3(n)		141993012
zebrafish (Danio rerio)	Actinopterygii	cenpa¹	histone H3-like centromeric protein A	55.81(n) 62.88(a)		100302659 NM_001164240.1 NP_001157712.1
fruit fly (Drosophila melanogaster)	Insecta	cid⁶	centromere identifier	22(a)	1 ↔ 1	2R(9373106-9374136)
worm (Caenorhabditis elegans)	Secernentea	cpar-1⁶ hcp-3⁶	Histone H3-like centromeric protein hcp-3	19(a) 19(a)	1 ↔ many 1 ↔ many	III(9433990-9435016) III(9615223-9616386)
thale cress (Arabidopsis thaliana)	eudicotyledons	HTR12⁶	histone H3	31(a)	1 ↔ 1	1(143564-145684)
rice (Oryza sativa)	Liliopsida	--	histone H3, putative, expressed	33(a)	1 ↔ 1	5(24005114-24007613)

ENSEMBL Gene Tree for CENPA (if available)
TreeFam Gene Tree for CENPA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
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Paralogs for CENPA gene

HIST2H3PS2²

18 SIMAP similar genes for CENPA using alignment to 2 protein entries: CENPA_HUMAN (see all proteins):

HIST1H3A HIST1H3B HIST1H3C HIST1H3D HIST1H3E HIST1H3F

HIST1H3G HIST1H3H HIST1H3I HIST1H3J HIST2H3A HIST2H3C

HIST2H3D HIST2H3PS2 HIST3H3 H3F3C H3F3A H3F3B

CENPA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
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SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75408399^1,2	C	--	27006982(+)	`CGGGAC/TGGTCT`	2	--	us2k¹		1		WA	2
rs10167038^1,2	C	--	27007062(+)	`ccacaC/Tccggc`	2	--	us2k¹		2		WA	120
rs147881511^1,2	C	--	27007075(+)	`TTTTC-/TTTTTT`	2	--	us2k¹		0	--	--	--	--
rs36048163^1,2	C	--	27007087(+)	`TTTTT-/TGAGAG`	2	--	us2k¹		0	--	--	--	--
rs10184206^1,2	C	--	27007088(+)	`tttctC/Tttttt`	2	--	us2k¹ trp³		1		WA	2
rs186971822^1,2		--	27007161(+)	`AGCCTC/TAACCT`	2	--	us2k¹		0	--	--	--	--
rs193081081^1,2		--	27007301(+)	`CTCCTC/TCTCCT`	2	--	us2k¹		0	--	--	--	--
rs34165519^1,2	C	--	27007428(+)	`GCAACT/CCTGCC`	2	--	us2k¹		3		NA	124
rs9807998^1,2	C,F	--	27007526(+)	`gttggC/Tcatgc`	2	--	us2k¹		3		NA WA CSA	6
rs79745576^1,2	C,F	--	27007614(+)	`ACGCTC/TGGCAA`	2	--	us2k¹		1		WA	118

HapMap Linkage Disequilibrium report for CENPA (26987157 - 27023935 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CENPA: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CENPA

DNA2.0 Custom Variant and Variant Library Synthesis for CENPA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CENPA for disorders           About GeneDecksing

OMIM gene information: 117139    OMIM disorders: --

15 diseases for CENPA:    About MalaCards

limited scleroderma systemic lupus erythematosus lupus erythematosus scleroderma

rheumatoid arthritis systemic scleroderma herpes simplex colorectal cancer

hepatitis b arthritis hepatocellular carcinoma breast cancer

hepatitis carcinoma malaria

8 Novoseek disease relationships for CENPA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sclerosis systemic	40.2	3	10648030 (2), 8223400 (1)
rheumatic diseases	30.6	1	8223400 (1)
autoimmune diseases	21.3	1	12019018 (1)
autoimmune response	18.8	1	17210244 (1)
tumors	1.65	3	12839935 (2)
rheumatoid arthritis	0	1	10648030 (1)
colorectal cancer	0	3	12839935 (2), 15930286 (1)
cancer	0	1	20119530 (1)

Export disorders for CENPA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CENPA gene, integrated from 9 sources (see all 175):
(articles sorted by number of sources associating them with CENPA)

Utopia: connect your pdf to the dynamic
world of online information

HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PubMed id 19410545)^{1, 2, 9} Dunleavy E.M....Almouzni-Pettinotti G. (2009)
Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. (PubMed id 9024683)^{1, 2, 9} Shelby R.D.... Sullivan K.F. (1997)
Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. (PubMed id 19543270)^{1, 2, 9} Carroll C.W.... Straight A.F. (2009)
Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. (PubMed id 18072184)^{1, 2, 9} Orthaus S....Diekmann S. (2008)
Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres. (PubMed id 15702419)^{1, 2, 9} Irvine D.V....Saffery R. (2004)
CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. (PubMed id 14667408)^{1, 2, 9} Kunitoku N.... Hirota T. (2003)
CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. (PubMed id 11756469)^{1, 2, 9} Zeitlin S.G.... Sullivan K.F. (2001)
Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3. (PubMed id 10759786)^{1, 2, 9} Muro Y....Sugimoto K. (2000)
Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP. (PubMed id 19410544)^{1, 2, 9} Foltz D.R.... Cleveland D.W. (2009)
Structural determinants for generating centromeric chromatin. (PubMed id 15282608)^{1, 2, 9} Black B.E....Cleveland D.W. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1058	HGNC: 1851	AceView: CENPAandC2orf18	Ensembl:ENSG00000115163	euGenes: HUgn1058
ECgene: CENPA	H-InvDB: CENPA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CENPA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CENPA	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CENPA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CENPA gene:
Search GeneIP for patents involving CENPA

GeneCards and IP:
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centromere protein A

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CENPA Gene

centromere protein A

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