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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CENPA Gene

protein-coding   GIFtS: 61
GCID: GC02P026988

Centromere Protein A

(Previous names: centromere protein A (17kD), centromere protein A, 17kDa)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Centromere Protein A1 2 3     Centromere Autoantigen A2 3
Centromere Protein A, 17kDa1 2     CENP-A2 3
Centromere-Specific Histone1 2     Centromere Protein A (17kD)1
Histone H3-Like Centromeric Protein A1 2     CenH32

External Ids:    HGNC: 18511   Entrez Gene: 10582   Ensembl: ENSG000001151637   OMIM: 1171395   UniProtKB: P494503   

Export aliases for CENPA gene to outside databases

Previous GC identifers: GC02P026908 GC02P027080 GC02P026962 GC02P026963 GC02P026898 GC02P026920 GC02P026750


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CENPA Gene:
Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA
encodes a centromere protein which contains a histone H3 related histone fold domain that is required for
targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like
structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the
nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CENPA Gene: 
CENPA (centromere protein A) is a protein-coding gene. Diseases associated with CENPA include limited scleroderma, and systemic scleroderma, and among its related super-pathways are Mitotic Anaphase and Mitotic Prometaphase. GO annotations related to this gene include chromatin binding and protein heterodimerization activity.

UniProtKB/Swiss-Prot: CENPA_HUMAN, P49450
Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric
chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins,
mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere
identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro)

Gene Wiki entry for CENPA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CENPA gene promoter:
         TBP   Sp1   TFIID   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCENPA promoter sequence
   Search SABiosciences Chromatin IP Primers for CENPA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CENPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

CENPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CENPA gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P026988:  view genomic region     (about GC identifiers)

Start:
26,987,157 bp from pter      End:
27,023,935 bp from pter
Size:
36,779 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CENPA_HUMAN, P49450 (See protein sequence)
Recommended Name: Histone H3-like centromeric protein A  
Size: 140 amino acids; 15991 Da
Subunit: Forms a nucleosome-like histone octamer containing two molecules each of H2A, H2B, CENPA and H4 assembled
in one CENPA-H4 heterotetramer and two H2A-H2B heterodimers. Nucleosomes containing CENPA also contain histone
H2A variants such as macroH2A H2AFY and H2A.Z/H2AFZ. The CENPA-H4 heterotetramer is more compact and structurally
more rigid than corresponding H3-H4 heterotetramers. Heterotrimer composed of HJURP, CENPA and histone H4, where
HJURP interacts with the dimer formed by CENPA and histone H4 and prevents tetramerization of CENPA and H4.
Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and
MLF1IP/CENPU. Interacts (via CATD domain) with HJURP; the interaction is direct and is required for its
localization to centromeres. Interacts with CENPC, CENPN and CENPT; interaction is direct. Interacts directly
with herpes virus HSV-1 ICP0 protein. Part of a centromere complex consisting of CENPA, CENPT and CENPW
Subcellular location: Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore
domain of centromeres. Occupies a compact domain at the inner kinetochore plate stretching across 2 thirds of the
length of the constriction but encompassing only one third of the constriction width and height
Miscellaneous: Antibodies against CENPA are present in sera from patients with autoimmune diseases that developed
autoantibodies against centrosomal proteins
4 PDB 3D structures from and Proteopedia for CENPA:
3AN2 (3D)        3NQJ (3D)        3NQU (3D)        3R45 (3D)    
Secondary accessions: D6W544 Q53T74 Q9BVW2
Alternative splicing: 2 isoforms:  P49450-1   P49450-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CENPA: NX_P49450

Explore proteomics data for CENPA at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated (Probable). Interaction with herpes virus HSV-1 ICP0 protein, leads to its degradation by the
    proteasome pathway
  • UniProtKB: Phosphorylation of Ser-7 by AURKA and AURKB during prophase is required for localization of AURKA and AURKB at
    inner centromere and is essential for kinetochore function. Initial phosphorylation during prophase is mediated
    by AURKA and is maintained by AURKB
  • UniProtKB: Poly-ADP-ribosylated by PARP1 (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P49450

  • CENPA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CENPA Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001035891.1  NP_001800.1  

    ENSEMBL proteins: 
     ENSP00000336868   ENSP00000233505   ENSP00000404963  
    Reactome Protein details: P49450
    Human Recombinant Protein Products for CENPA: 
    EMD Millipore Purified and/or Recombinant CENPA Protein
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    Novus Biologicals CENPA Protein
    Novus Biologicals CENPA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CENPA
    Cloud-Clone Corp. Proteins for CENPA 

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IDA11084331
    GO:0000778condensed nuclear chromosome kinetochore IDA18195732
    GO:0000780condensed nuclear chromosome, centromeric region IDA11682612
    GO:0000786nucleosome IEA--
    GO:0000939condensed chromosome inner kinetochore IEA--

    CENPA for ontologies           About GeneDecksing



    CENPA Antibody Products: 
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    Cloud-Clone Corp. Antibodies for CENPA 
    ThermoFisher Antibodies for CENPA
    LSBio Antibodies in human, mouse, rat for CENPA 

    Assay Products for CENPA: 
    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for CENPA 
    Cloud-Clone Corp. CLIAs for CENPA


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR000164 Histone_H3
     IPR009072 Histone-fold
     IPR007125 Histone_core_D

    Graphical View of Domain Structure for InterPro Entry P49450

    ProtoNet protein and cluster: P49450

    1 Blocks protein domain: IPB000164 Histone H3

    UniProtKB/Swiss-Prot: CENPA_HUMAN, P49450
    Domain: The CATD (CENPA targeting domain) region is responsible for the more compact structure of nucleosomes
    containing CENPA and is necessary and sufficient to mediate the localization into centromeres
    Similarity: Belongs to the histone H3 family


    CENPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CENPA_HUMAN, P49450
    Function: Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric
    chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins,
    mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere
    identity through replication and cell division. The CENPA-H4 heterotetramer can bind DNA by itself (in vitro)

         Genatlas biochemistry entry for CENPA:
    centromeric protein A,histone H3 related,likely replaying H3 to form a centromere unique nucleosomal structure

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003682chromatin binding TAS7962047
    GO:0005515protein binding IPI19410544
    GO:0046982protein heterodimerization activity IEA--
         
    CENPA for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for CENPA:
     Decreased POU5F1-GFP protein e  Decreased viability of wild-ty  Upregulation of Wnt/beta-caten 

         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cenpa):
     cardiovascular system  cellular  craniofacial  embryogenesis  growth/size 
     mortality/aging  nervous system 

    CENPA for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CENPA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CENPA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CENPA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CENPA 

    miRNA
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    hsa-miR-548n hsa-miR-3647-3p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidCENPA 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): CENPA (NM_001809)
    Sino Biological Human cDNA Clone for CENPA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CENPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CENPA
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                         Customized lentivirus expression plasmids for stable overexpression of CENPA 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CENPA About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1M Phase
    Mitotic Anaphase0.94
    M Phase0.88
    Separation of Sister Chromatids0.94
    Mitotic M-M/G1 phases0.88
    Mitotic Metaphase and Anaphase0.94
    2Resolution of Sister Chromatid Cohesion
    Resolution of Sister Chromatid Cohesion0.93
    Mitotic Prometaphase0.93
    3Cell Cycle
    Cell Cycle, Mitotic0.84
    Cell Cycle0.84
    4Packaging Of Telomere Ends
    Nucleosome assembly0.46
    Deposition of New CENPA-containing Nucleosomes at the Centromere0.46
    5Meiotic Synapsis
    Chromosome Maintenance0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CENPA
        Chromatin Regulation / Acetylation
    Cell Cycle / Checkpoint Control

    3 BioSystems Pathways for CENPA
        Aurora B signaling
    Aurora A signaling
    FOXM1 transcription factor network


    5/12        Reactome Pathways for CENPA (see all 12)
        Mitotic Metaphase and Anaphase
    Mitotic Prometaphase
    Resolution of Sister Chromatid Cohesion
    Nucleosome assembly
    Mitotic Anaphase



    CENPA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CENPA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/166 Interacting proteins for CENPA (P494501, 2, 3 ENSP000003368684) via UniProtKB, MINT, STRING, and/or I2D (see all 166)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4BP628051, 3, ENSP000003665814EBI-1751979,EBI-302023 I2D: score=3 STRING: ENSP00000366581
    HIST1H4CP628051, 3EBI-1751979,EBI-302023 I2D: score=3 
    HIST1H4DP628051, 3EBI-1751979,EBI-302023 I2D: score=3 
    HIST1H4EP628051, 3EBI-1751979,EBI-302023 I2D: score=3 
    HIST1H4FP628051, 3EBI-1751979,EBI-302023 I2D: score=3 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000132establishment of mitotic spindle orientation IMP19468067
    GO:0000278mitotic cell cycle TAS--
    GO:0006334nucleosome assembly TAS--
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0034080CENP-A containing nucleosome assembly at centromere TAS--

    CENPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CENPA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CENPA

    2 Novoseek inferred chemical compound relationships for CENPA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hydrogen 0 1 15282608 (1)
    glycerol 0 1 10840064 (1)

    Search CenterWatch for drugs/clinical trials and news about CENPA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CENPA gene (2 alternative transcripts): 
    NM_001042426.1  NM_001809.3  

    Unigene Cluster for CENPA:

    Centromere protein A
    Hs.1594  [show with all ESTs]
    Unigene Representative Sequence: BM911202
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000475662 ENST00000335756(uc002rhr.3 uc002rhs.3) ENST00000472719
    ENST00000233505 ENST00000419525 ENST00000460030(uc002rht.3)
    miRNA
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    hsa-miR-548n hsa-miR-3647-3p hsa-miR-3916 hsa-miR-3125
    SwitchGear 3'UTR luciferase reporter plasmidCENPA 3' UTR sequence
    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CENPA

    Additional mRNA sequence: 

    BC000881.1 BC002703.2 BC011013.1 BT007246.1 U14518.1 

    4 DOTS entries:

    DT.313100  DT.100748001  DT.91749874  DT.95162633 

    24/235 AceView cDNA sequences (see all 235):

    BE677115 AI611022 AI015703 AI394337 AA742587 BU501174 BQ945655 AI792646 
    BM721691 BX108564 AI202608 BM790060 NM_001809 BC035519 AI685226 NM_017877 
    AA609044 BC000881 BC028081 AA749306 AI452465 AK025889 BM979301 BM831793 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CENPA (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                                                                                
    SP2:                                                                                                
    SP3:              -                                                                                 
    SP4:                    -                                                                           
    SP5:                                                                                -               


    ECgene alternative splicing isoforms for CENPA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CENPA expression in normal human tissues (normalized intensities)      CENPA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAACTGAGTG
    CENPA Expression
    About this image


    CENPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/28 selected tissues (see all 28) fully expand
     
     Colon (Gastrointestinal Tract)    fully expand to see all 3 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 3 entries
             small intestine ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   
     
     Uterus (Reproductive System)    fully expand to see all 2 entries
             cervix, uterine ; glandular cells   
             CERVIX   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Postnatal Endothelial Cells Blood Brain Barrier
             colon ; endothelial cells   

    See CENPA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CENPA

    SOURCE GeneReport for Unigene cluster: Hs.1594
        SABiosciences Custom PCR Arrays for CENPA
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CENPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CENPA gene from 8/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cenpa1 , 5 centromere protein A1, 5 73.54(n)1
    77.1(a)1
      5 (16.76 cM)5
    126151  NM_007681.21  NP_031707.11 
     306667775 
    chicken
    (Gallus gallus)
    Aves CENPA1 centromere protein A 60.43(n)
    62.6(a)
      100113359  NM_001101037.1  NP_001094507.1 
    lizard
    (Anolis carolinensis)
    Reptilia CENPA6
    Uncharacterized protein
    46(a)
    1 ↔ 1
    2(198063250-198095686)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1419930122   -- 67.3(n)    141993012 
    zebrafish
    (Danio rerio)
    Actinopterygii cenpa1 histone H3-like centromeric protein A 55.81(n)
    62.88(a)
      100302659  NM_001164240.1  NP_001157712.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cid6
    centromere identifier
    17(a)
    1 ↔ 1
    2R(9373106-9374136)
    worm
    (Caenorhabditis elegans)
    Secernentea cpar-16
    hcp-36
    Histone H3-like centromeric protein hcp-3
    19(a)
    19(a)
    many → 1
    many → 1
    III(9434074-9435100)
    III(9615307-9616470)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CSE46
    Centromere protein that resembles histone H3, requ...
    22(a)
    1 ↔ 1
    XI(346075-346764)


    ENSEMBL Gene Tree for CENPA (if available)
    TreeFam Gene Tree for CENPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CENPA gene
    18 SIMAP similar genes for CENPA using alignment to 2 protein entries:     CENPA_HUMAN (see all proteins):
    HIST1H3A    HIST1H3B    HIST1H3C    HIST1H3D    HIST1H3E    HIST1H3F
    HIST1H3G    HIST1H3H    HIST1H3I    HIST1H3J    HIST2H3A    HIST2H3C
    HIST2H3D    HIST2H3PS2    HIST3H3    H3F3C    H3F3A    H3F3B

    CENPA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/193 SNPs in CENPA are shown (see all 193)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs754083991,2
    C,F--27006982(+) CGGGAC/TGGTCT 2 -- us2k11Minor allele frequency- T:0.50WA 2
    rs101670381,2
    C,F--27007062(+) ccacaC/Tccggc 2 -- us2k12Minor allele frequency- T:0.22WA 120
    rs2007665201,2
    C--27007086(+) TTTTTC/TTTTTT 2 -- us2k10--------
    rs101842061,2
    C,F--27007088(+) tttctC/Tttttt 2 -- us2k1 trp31Minor allele frequency- T:0.50WA 2
    rs360481631,2
    C--27007095(+) TTTTT-/TGAGAG 2 -- us2k10--------
    rs1869718221,2
    --27007161(+) AGCCTC/TAACCT 2 -- us2k10--------
    rs1930810811,2
    --27007301(+) CTCCTC/TCTCCT 2 -- us2k10--------
    rs341655191,2
    C,F--27007428(+) GCAACT/CCTGCC 2 -- us2k13Minor allele frequency- C:0.05NA 124
    rs98079981,2
    C,F--27007526(+) gttggC/Tcatgc 2 -- us2k13Minor allele frequency- T:0.50NA WA CSA 6
    rs797455761,2
    C,F--27007614(+) ACGCTC/TGGCAA 2 -- us2k11Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for CENPA (26987157 - 27023935 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CENPA: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CENPA
    DNA2.0 Custom Variant and Variant Library Synthesis for CENPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 117139    OMIM disorders: --

    15 diseases for CENPA:    About MalaCards
    limited scleroderma    systemic scleroderma    scleroderma    herpes simplex
    colorectal cancer    rheumatoid arthritis    systemic lupus erythematosus    arthritis
    lung adenocarcinoma    lupus erythematosus    hepatitis b    hepatocellular carcinoma
    hepatitis    breast cancer    adenocarcinoma


    CENPA for disorders           About GeneDecksing

    8 Novoseek inferred disease relationships for CENPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sclerosis systemic 40.2 3 10648030 (2), 8223400 (1)
    rheumatic diseases 30.6 1 8223400 (1)
    autoimmune diseases 21.3 1 12019018 (1)
    autoimmune response 18.8 1 17210244 (1)
    tumors 1.65 3 12839935 (2)
    rheumatoid arthritis 0 1 10648030 (1)
    colorectal cancer 0 3 12839935 (2), 15930286 (1)
    cancer 0 1 20119530 (1)


    Export disorders for CENPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CENPA gene, integrated from 9 sources (see all 182):
    (articles sorted by number of sources associating them with CENPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. (PubMed id 19410545)1, 2, 9 Dunleavy E.M....Almouzni-Pettinotti G. (2009)
    2. Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. (PubMed id 9024683)1, 2, 9 Shelby R.D.... Sullivan K.F. (1997)
    3. Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. (PubMed id 19543270)1, 2, 9 Carroll C.W.... Straight A.F. (2009)
    4. Assembly of the inner kinetochore proteins CENP-A and CENP-B in living human cells. (PubMed id 18072184)1, 2, 9 Orthaus S....Diekmann S. (2008)
    5. Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres. (PubMed id 15702419)1, 2, 9 Irvine D.V....Saffery R. (2004)
    6. CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. (PubMed id 14667408)1, 2, 9 Kunitoku N.... Hirota T. (2003)
    7. CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. (PubMed id 11756469)1, 2, 9 Zeitlin S.G.... Sullivan K.F. (2001)
    8. Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3. (PubMed id 10759786)1, 2, 9 Muro Y....Sugimoto K. (2000)
    9. Centromere-specific assembly of CENP-A nucleosomes is mediated by HJURP. (PubMed id 19410544)1, 2, 9 Foltz D.R.... Cleveland D.W. (2009)
    10. Structural determinants for generating centromeric chromatin. (PubMed id 15282608)1, 2, 9 Black B.E....Cleveland D.W. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1058 HGNC: 1851 AceView: CENPAandC2orf18 Ensembl:ENSG00000115163 euGenes: HUgn1058
    ECgene: CENPA H-InvDB: CENPA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CENPA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CENPA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CENPA gene:
    Search GeneIP for patents involving CENPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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