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Aliases for CEND1 Gene

Aliases for CEND1 Gene

  • Cell Cycle Exit And Neuronal Differentiation 1 2 3 5
  • BM88 Antigen 3 4
  • BM88 3 4
  • Cell Cycle Exit And Neuronal Differentiation Protein 1 3

External Ids for CEND1 Gene

Previous GeneCards Identifiers for CEND1 Gene

  • GC11M000786
  • GC11M000603

Summaries for CEND1 Gene

Entrez Gene Summary for CEND1 Gene

  • The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEND1 Gene

CEND1 (Cell Cycle Exit And Neuronal Differentiation 1) is a Protein Coding gene. Diseases associated with CEND1 include Neuroblastoma and Beckwith-Wiedemann Syndrome. Among its related pathways are Neuroscience and DNA Damage.

UniProtKB/Swiss-Prot for CEND1 Gene

  • Involved in neuroblastoma cell differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEND1 Gene

Genomics for CEND1 Gene

Regulatory Elements for CEND1 Gene

Enhancers for CEND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CEND1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEND1 Gene

Chromosome:
11
Start:
787,104 bp from pter
End:
790,126 bp from pter
Size:
3,023 bases
Orientation:
Minus strand

Genomic View for CEND1 Gene

Genes around CEND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEND1 Gene

Proteins for CEND1 Gene

  • Protein details for CEND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N111-CEND_HUMAN
    Recommended name:
    Cell cycle exit and neuronal differentiation protein 1
    Protein Accession:
    Q8N111
    Secondary Accessions:
    • Q9NYM6

    Protein attributes for CEND1 Gene

    Size:
    149 amino acids
    Molecular mass:
    14954 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for CEND1 Gene

Post-translational modifications for CEND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CEND1 (CEND1)

No data available for DME Specific Peptides for CEND1 Gene

Domains & Families for CEND1 Gene

Protein Domains for CEND1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N111

UniProtKB/Swiss-Prot:

CEND_HUMAN :
  • Belongs to the CEND1 family.
Family:
  • Belongs to the CEND1 family.
genes like me logo Genes that share domains with CEND1: view

No data available for Gene Families for CEND1 Gene

Function for CEND1 Gene

Molecular function for CEND1 Gene

UniProtKB/Swiss-Prot Function:
Involved in neuroblastoma cell differentiation.
genes like me logo Genes that share phenotypes with CEND1: view

Animal Models for CEND1 Gene

MGI Knock Outs for CEND1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CEND1

CRISPR Products

miRNA for CEND1 Gene

miRTarBase miRNAs that target CEND1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEND1 Gene

Localization for CEND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEND1 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEND1 Gene COMPARTMENTS Subcellular localization image for CEND1 gene
Compartment Confidence
nucleus 2
peroxisome 2
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CEND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEND1: view

Pathways & Interactions for CEND1 Gene

SuperPathways for CEND1 Gene

Superpath Contained pathways
1 DNA Damage
2 Neuroscience
genes like me logo Genes that share pathways with CEND1: view

Pathways by source for CEND1 Gene

2 Cell Signaling Technology pathways for CEND1 Gene

Interacting Proteins for CEND1 Gene

Gene Ontology (GO) - Biological Process for CEND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007628 adult walking behavior IEA --
GO:0021686 cerebellar granular layer maturation IEA --
GO:0021702 cerebellar Purkinje cell differentiation IEA --
GO:0021933 radial glia guided migration of cerebellar granule cell IEA --
GO:0021941 negative regulation of cerebellar granule cell precursor proliferation IEA --
genes like me logo Genes that share ontologies with CEND1: view

No data available for SIGNOR curated interactions for CEND1 Gene

Drugs & Compounds for CEND1 Gene

No Compound Related Data Available

Transcripts for CEND1 Gene

mRNA/cDNA for CEND1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(101) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEND1 Gene

Cell cycle exit and neuronal differentiation 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEND1 Gene

No ASD Table

Relevant External Links for CEND1 Gene

GeneLoc Exon Structure for
CEND1
ECgene alternative splicing isoforms for
CEND1

Expression for CEND1 Gene

mRNA expression in normal human tissues for CEND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEND1 Gene

This gene is overexpressed in Brain - Cortex (x7.0), Brain - Frontal Cortex (BA9) (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cerebellum (x4.4), Brain - Hippocampus (x4.1), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for CEND1 Gene

This gene is overexpressed in Frontal cortex (35.9) and Brain (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEND1 Gene



Protein tissue co-expression partners for CEND1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEND1 Gene:

CEND1

SOURCE GeneReport for Unigene cluster for CEND1 Gene:

Hs.22140

mRNA Expression by UniProt/SwissProt for CEND1 Gene:

Q8N111-CEND_HUMAN
Tissue specificity: Neuron specific.
genes like me logo Genes that share expression patterns with CEND1: view

Primer Products

Orthologs for CEND1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEND1 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Cend1 34
  • 82.19 (n)
  • 82.19 (a)
Cend1 16
Cend1 35
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEND1 34
  • 99.11 (n)
  • 98.66 (a)
CEND1 35
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEND1 35
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEND1 35
  • 79 (a)
OneToOne
Species where no ortholog for CEND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEND1 Gene

ENSEMBL:
Gene Tree for CEND1 (if available)
TreeFam:
Gene Tree for CEND1 (if available)

Paralogs for CEND1 Gene

Pseudogenes.org Pseudogenes for CEND1 Gene

genes like me logo Genes that share paralogs with CEND1: view

No data available for Paralogs for CEND1 Gene

Variants for CEND1 Gene

Sequence variations from dbSNP and Humsavar for CEND1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7946354 -- 787,679(-) TACCC(A/C)CCGGG utr-variant-3-prime
rs9943678 -- 786,953(+) GGTGG(C/G)GATCC downstream-variant-500B
rs10603197 -- 787,320(+) GGGCT(-/GAG)GACAG cds-indel
rs34020622 -- 789,214(+) CACAA(-/A)GAACC intron-variant
rs34551964 -- 787,651(+) GTCCC(-/C)ACTGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEND1 Gene

Variant ID Type Subtype PubMed ID
dgv1013n100 CNV gain 25217958
dgv182e199 CNV deletion 23128226
esv2759794 CNV loss 17122850
nsv1040044 CNV gain+loss 25217958
nsv1069539 CNV deletion 25765185
nsv1159791 CNV deletion 26073780
nsv469923 CNV loss 18288195
nsv552870 CNV loss 21841781
nsv552871 CNV loss 21841781
nsv8759 CNV gain 18304495
nsv951272 CNV deletion 24416366

Variation tolerance for CEND1 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEND1 Gene

Disorders for CEND1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEND1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
neuroblastoma
  • neuroblastoma 1
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CEND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEND1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEND1
genes like me logo Genes that share disorders with CEND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEND1 Gene

Publications for CEND1 Gene

  1. Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis. (PMID: 11311134) Gaitanou M. … Matsas R. (Biochem. J. 2001) 2 3 4 65
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3 65
  5. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. (PMID: 20029029) Deribe Y.L. … Dikic I. (Sci Signal 2009) 3 65

Products for CEND1 Gene

Sources for CEND1 Gene

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