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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CEND1 Gene

protein-coding GIFtS: 48
GCID: GC11M000786

cell cycle exit and neuronal differentiation 1

Explore 4 diseases affiliated with
CEND1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cell Cycle Exit And Neuronal Differentiation 1¹ ²
BM88¹ ² ³ ⁵
BM88 Antigen² ³
FLJ90066¹
Cell Cycle Exit And Neuronal Differentiation Protein 1²

External Ids:	HGNC: 24153¹	Entrez Gene: 51286²	Ensembl: ENSG00000184524⁷	OMIM: 608213⁵	UniProtKB: Q8N111³

Export aliases for CEND1 gene to outside databases

Previous GC identifer: GC11M000603

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEND1:

The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell

differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been

reported for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CEND_HUMAN, Q8N111

Function: Involved in neuroblastoma cell differentiation (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_009237.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CEND1 gene promoter:
Oct-B1 oct-B2 oct-B3 Pax-5 p53 p300 YY1 POU2F1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CEND1 promoter sequence

Search SABiosciences Chromatin IP Primers for CEND1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEND1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.5 Ensembl cytogenetic band: 11p15.5 HGNC cytogenetic band: 11p15.5

CEND1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEND1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M000786: view genomic region (about GC identifiers)

Start:	787,104 bp from pter	End:	790,126 bp from pter
Size:	3,023 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CEND_HUMAN, Q8N111 (See protein sequence)

Recommended Name: Cell cycle exit and neuronal differentiation protein 1

Size: 149 amino acids; 14954 Da

Subunit: Homodimer (By similarity)

Subcellular location: Membrane; Single-pass type IV membrane protein (Potential)

Secondary accessions: Q9NYM6

Explore the universe of human proteins at neXtProt for CEND1: NX_Q8N111

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N111

CEND1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_057648.2

ENSEMBL proteins:

ENSP00000328336

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

CEND1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CEND1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CEND1 for domains About GeneDecksing

1 InterPro domain/family:

IPR020162 Cend1

Graphical View of Domain Structure for InterPro Entry Q8N111

ProtoNet protein and cluster: Q8N111

UniProtKB/Swiss-Prot: CEND_HUMAN, Q8N111

Similarity: Belongs to the CEND1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CEND_HUMAN, Q8N111

Function: Involved in neuroblastoma cell differentiation (By similarity)

miRNA Products:		OriGene 3'-UTR Clone: CEND1 Browse MicroRNA Expression Plasmids
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEND1

Animal Models:
3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cend1):

behavior/neurological

cellular

nervous system

CEND1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell Cycle / Checkpoint Control

Cell Cycle / Checkpoint Control

1.00

Neuroscience

Neuroscience

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for CEND1

	Cell Cycle / Checkpoint Control
	Neuroscience

CEND1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CEND1

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for CEND1 (Q8N111^{2, 3} ENSP00000328336⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UBQLN4	Q9NRR5²^,³, ENSP00000357292⁴	MINT-2873110 I2D: score=3 STRING: ENSP00000357292
EGFR	P00533³, ENSP00000275493⁴	I2D: score=2 STRING: ENSP00000275493

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEND1
Search CenterWatch for drugs/clinical trials and news about CEND1 / CEND

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for CEND1 gene:

NM_016564.3

Unigene Cluster for CEND1:

Cell cycle exit and neuronal differentiation 1

Hs.22140 [show with all ESTs]

Unigene Representative Sequence: BC034732

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000330106(uc001lrh.1) ENST00000524587

miRNA Products:		OriGene 3'-UTR Clone: CEND1 Browse OriGene MicroRNA Expression Plasmids
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		8/15 QIAGEN miScript miRNA Assays for microRNAs that regulate CEND1 (see all 15):
		hsa-miR-137 hsa-miR-92a hsa-miR-25 hsa-miR-367 hsa-let-7a-2* hsa-miR-32 hsa-miR-33a hsa-let-7e*

		SwitchGear 3'UTR luciferase reporter plasmid: CEND1 3' UTR sequence

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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEND1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEND1

Additional cDNA sequence:

AF235030.1 AK074547.1 AK312993.1 BC034732.1

5 DOTS entries:

DT.310371 DT.120720817 DT.120720857 DT.120720819 DT.40109665

24/101 AceView cDNA sequences (see all 101):

BM932330 AW452289 BM661609 BQ722366 BM700533 BQ070321 BM662871 BM920640

CB156402 BQ067047 AI278196 BQ897822 BQ717439 BQ882441 AI568561 BF346149

BX460412 BM686147 BI752376 BQ068994 BX413253 BP348130 BP361033 CD628022

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEND1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CAGAGTTCAC

About this image

CEND1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Eye

Retina

Eye

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CEND1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEND1

SOURCE GeneReport for Unigene cluster: Hs.22140

UniProtKB/Swiss-Prot: CEND_HUMAN, Q8N111

Tissue specificity: Neuron specific

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CEND1 gene from 3/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cend1^{1 , 5}	cell cycle exit and neuronal differentiation 1^{1, 5}	81.96(n)¹ 82.19(a)¹		7 (86.77 cM)⁵ 57754¹ NM_021316.4¹ NP_067291.1¹ 141426446⁵
chicken (Gallus gallus)	Aves	CEND1¹	cell cycle exit and neuronal differentiation 1	58.53(n) 50.39(a)		770044 NM_001193263.1 NP_001180192.1
lizard (Anolis carolinensis)	Reptilia	CEND1⁶	--	41(a)	1 ↔ 1	1(73931126-73931545)

ENSEMBL Gene Tree for CEND1 (if available)
TreeFam Gene Tree for CEND1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CEND1 gene

CEND1 for paralogs About GeneDecksing

2 Pseudogenes.org Pseudogenes for CEND1
PGOHUM00000248532 PGOHUM00000248280

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs4963154^1,2	C,A,H	--	607019(-)	`ACCCCG/TCAGTT`	3	--	ds500¹		5		NS EA NA	418
rs74573437^1,2	F,	--	607184(+)	`GTTATG/AGGAAG`	3	--	ds500¹		2		NA EA	240
rs118051043^1,2	C,F,	--	607775(+)	`NNNNCC/TGCCCT`	3	--	ut3¹		2		NA EA	240
rs112476979^1,2	C,	--	608245(+)	`GAGCCG/ACTTGG`	3	--	ut3¹		2		CSA WA	120
rs4963152^1,2	C	--	608574(-)	`CTCCCG/ATCGGC`	3	--	ut3¹		1		CSA	2
rs116027726^1,2	F,	--	786617(+)	`GGCACC/TGCAGG`	1	--	ds500¹		1		WA	118
rs183863172^1,2		--	786641(+)	`TGGCCC/TGCATG`	1	--	ds500¹		0	--	--	--	--
rs149486689^1,2		--	786660(+)	`CCACCC/TGTGGC`	1	--	ds500¹		0	--	--	--	--
rs7111306^1,2	C,	--	786684(-)	`CCGGCG/CGGCCT`	1	--	ds500¹		2		NA	122
rs188639940^1,2		--	786789(+)	`GGCTGC/TGGAAG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CEND1 (787104 - 790126 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for CEND1
4 CNVs: 30530 3831 29883 29885

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEND1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CEND1 for disorders           About GeneDecksing

OMIM gene information: 608213    OMIM disorders: --

4 diseases for CEND1:    About MalaCards

neuronitis beckwith-wiedemann syndrome neuroblastoma ataxia

Export disorders for CEND1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CEND1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CEND1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis. (PubMed id 11311134)^{1, 2, 3} Gaitanou M.... Matsas R. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Regulation of epidermal growth factor receptor traffi cking by lysine deacetylase HDAC6. (PubMed id 20029029)¹ Deribe Y.L....Dikic I. (2009)
BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells. (PubMed id 18499894)¹ Katsimpardi L....Thomaidou D. (2008)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)¹ Lim J.... Zoghbi H.Y. (2006)
Characterization of the BM88 promoter and identification of an 88 bp fragment sufficient to drive neurone-specific expression. (PubMed id 16181419)¹ Papadodima O....Matsas R. (2005)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 51286	HGNC: 24153	AceView: BM88	Ensembl:ENSG00000184524	euGenes: HUgn51286
ECgene: CEND1	H-InvDB: CEND1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CEND1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CEND1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CEND1 gene:
Search GeneIP for patents involving CEND1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CEND1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CEND1		OriGene Custom Protein Services for CEND1
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEND1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEND1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEND1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEND1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEND1
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	GenScript Custom Purified and Recombinant Proteins Services for CEND1		GenScript cDNA clones with any tag delivered in your preferred vector for CEND1
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	GenScript Custom overexpressing Cell Line Services for CEND1		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Antibodies & Assays for CEND1

	Regulatory tfbs in CEND1 promoter
	Search Chromatin IP Primers for CEND1
	RT² qPCR Primer Assay in human, mouse, rat CEND1
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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CEND1 Proteins, Antibodies, CLIAs, and ELISAs

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEND1

	SwitchGear 3'UTR luciferase reporter plasmids for CEND1
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ThermoFisher Antibodies for CEND1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEND1

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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CEND1 Gene

cell cycle exit and neuronal differentiation 1

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CEND1 Gene

cell cycle exit and neuronal differentiation 1

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for CEND1 gene

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for CEND1 gene

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