Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEND1 Gene

Aliases for CEND1 Gene

  • Cell Cycle Exit And Neuronal Differentiation 1 2 3 5
  • BM88 Antigen 3 4
  • BM88 3 4

External Ids for CEND1 Gene

Previous GeneCards Identifiers for CEND1 Gene

  • GC11M000786
  • GC11M000603

Summaries for CEND1 Gene

Entrez Gene Summary for CEND1 Gene

  • The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEND1 Gene

CEND1 (Cell Cycle Exit And Neuronal Differentiation 1) is a Protein Coding gene. Diseases associated with CEND1 include Neuroblastoma and Joubert Syndrome 1. Among its related pathways are DNA Damage and Neuroscience.

UniProtKB/Swiss-Prot for CEND1 Gene

  • Involved in neuroblastoma cell differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEND1 Gene

Genomics for CEND1 Gene

Regulatory Elements for CEND1 Gene

Enhancers for CEND1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEND1 on UCSC Golden Path with GeneCards custom track

Promoters for CEND1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEND1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEND1 Gene

787,104 bp from pter
790,126 bp from pter
3,023 bases
Minus strand

Genomic View for CEND1 Gene

Genes around CEND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEND1 Gene

Proteins for CEND1 Gene

  • Protein details for CEND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell cycle exit and neuronal differentiation protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9NYM6

    Protein attributes for CEND1 Gene

    149 amino acids
    Molecular mass:
    14954 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for CEND1 Gene

Proteomics data for CEND1 Gene at MOPED

Post-translational modifications for CEND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CEND1 (CEND1)

No data available for DME Specific Peptides for CEND1 Gene

Domains & Families for CEND1 Gene

Protein Domains for CEND1 Gene


Suggested Antigen Peptide Sequences for CEND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CEND1 family.
  • Belongs to the CEND1 family.
genes like me logo Genes that share domains with CEND1: view

No data available for Gene Families for CEND1 Gene

Function for CEND1 Gene

Molecular function for CEND1 Gene

UniProtKB/Swiss-Prot Function:
Involved in neuroblastoma cell differentiation.
genes like me logo Genes that share phenotypes with CEND1: view

Animal Models for CEND1 Gene

MGI Knock Outs for CEND1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CEND1

CRISPR Products

miRNA for CEND1 Gene

miRTarBase miRNAs that target CEND1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEND1 Gene

Localization for CEND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEND1 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

Jensen Localization Image for CEND1 Gene COMPARTMENTS Subcellular localization image for CEND1 gene
Compartment Confidence
nucleus 2
peroxisome 2
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CEND1 Gene

Pathways & Interactions for CEND1 Gene

SuperPathways for CEND1 Gene

Superpath Contained pathways
1 DNA Damage
2 Neuroscience
genes like me logo Genes that share pathways with CEND1: view

Pathways by source for CEND1 Gene

2 Cell Signaling Technology pathways for CEND1 Gene

Interacting Proteins for CEND1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q8N111-CEND_HUMAN ENSP00000328336 for CEND1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CEND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0021686 cerebellar granular layer maturation IEA --
GO:0021702 cerebellar Purkinje cell differentiation IEA --
GO:0021933 radial glia guided migration of cerebellar granule cell IEA --
genes like me logo Genes that share ontologies with CEND1: view

No data available for SIGNOR curated interactions for CEND1 Gene

Drugs & Compounds for CEND1 Gene

No Compound Related Data Available

Transcripts for CEND1 Gene

mRNA/cDNA for CEND1 Gene

Unigene Clusters for CEND1 Gene

Cell cycle exit and neuronal differentiation 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEND1 Gene

No ASD Table

Relevant External Links for CEND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEND1 Gene

mRNA expression in normal human tissues for CEND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEND1 Gene

This gene is overexpressed in Brain - Cortex (x7.0), Brain - Frontal Cortex (BA9) (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cerebellum (x4.4), Brain - Hippocampus (x4.1), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for CEND1 Gene

This gene is overexpressed in Frontal cortex (35.9) and Brain (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CEND1 Gene

SOURCE GeneReport for Unigene cluster for CEND1 Gene Hs.22140

mRNA Expression by UniProt/SwissProt for CEND1 Gene

Tissue specificity: Neuron specific.
genes like me logo Genes that share expression patterns with CEND1: view

Protein tissue co-expression partners for CEND1 Gene

- Elite partner

Primer Products

Orthologs for CEND1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Cend1 35
  • 82.19 (n)
  • 82.19 (a)
Cend1 16
Cend1 36
  • 79 (a)
(Pan troglodytes)
Mammalia CEND1 35
  • 99.11 (n)
  • 98.66 (a)
CEND1 36
  • 99 (a)
(Bos Taurus)
Mammalia CEND1 36
  • 75 (a)
(Canis familiaris)
Mammalia CEND1 36
  • 79 (a)
Species with no ortholog for CEND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEND1 Gene

Gene Tree for CEND1 (if available)
Gene Tree for CEND1 (if available)

Paralogs for CEND1 Gene Pseudogenes for CEND1 Gene

genes like me logo Genes that share paralogs with CEND1: view

No data available for Paralogs for CEND1 Gene

Variants for CEND1 Gene

Sequence variations from dbSNP and Humsavar for CEND1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11549485 -- 788,357(+) TCAAC(A/C/G/T)ACCAC reference, missense
rs11822361 -- 786,975(+) CCTGG(A/G)ATAAG downstream-variant-500B
rs11822365 -- 787,041(+) TGGAA(A/G)GCCTG downstream-variant-500B
rs11822382 -- 787,064(+) GACAC(A/G)TGCGA downstream-variant-500B
rs7483022 -- 787,571(-) GTGGG(A/C)AGACG utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEND1 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
nsv896583 CNV Gain 21882294
dgv946n71 CNV Loss 21882294
nsv896587 CNV Loss 21882294
essv11734 CNV CNV 17122850
nsv8759 CNV Gain 18304495
dgv947n71 CNV Loss 21882294
dgv948n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294

Variation tolerance for CEND1 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.52% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEND1 Gene

Disorders for CEND1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEND1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CEND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEND1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CEND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEND1 Gene

Publications for CEND1 Gene

  1. Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis. (PMID: 11311134) Gaitanou M. … Matsas R. (Biochem. J. 2001) 2 3 4 67
  2. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X. … Wheeler M.B. (Mol. Endocrinol. 2013) 3
  3. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. (PMID: 20029029) Deribe Y.L. … Dikic I. (Sci Signal 2009) 3
  4. BM88/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells. (PMID: 18499894) Katsimpardi L. … Thomaidou D. (Stem Cells 2008) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CEND1 Gene

Sources for CEND1 Gene