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Aliases for CEND1 Gene

Aliases for CEND1 Gene

  • Cell Cycle Exit And Neuronal Differentiation 1 2 3
  • BM88 3 4 6
  • BM88 Antigen 3 4
  • Cell Cycle Exit And Neuronal Differentiation Protein 1 3

External Ids for CEND1 Gene

Previous GeneCards Identifiers for CEND1 Gene

  • GC11M000786
  • GC11M000603

Summaries for CEND1 Gene

Entrez Gene Summary for CEND1 Gene

  • The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEND1 Gene

CEND1 (Cell Cycle Exit And Neuronal Differentiation 1) is a Protein Coding gene. Diseases associated with CEND1 include neuroblastoma. Among its related pathways are Cell Cycle / Checkpoint Control and Neuroscience.

UniProtKB/Swiss-Prot for CEND1 Gene

  • Involved in neuroblastoma cell differentiation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEND1 Gene

Genomics for CEND1 Gene

Regulatory Elements for CEND1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEND1 Gene

Start:
787,104 bp from pter
End:
790,126 bp from pter
Size:
3,023 bases
Orientation:
Minus strand

Genomic View for CEND1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEND1 Gene

Proteins for CEND1 Gene

  • Protein details for CEND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N111-CEND_HUMAN
    Recommended name:
    Cell cycle exit and neuronal differentiation protein 1
    Protein Accession:
    Q8N111
    Secondary Accessions:
    • Q9NYM6

    Protein attributes for CEND1 Gene

    Size:
    149 amino acids
    Molecular mass:
    14954 Da
    Quaternary structure:
    • Homodimer.

neXtProt entry for CEND1 Gene

Proteomics data for CEND1 Gene at MOPED

Post-translational modifications for CEND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CEND1 (CEND1)

No data available for DME Specific Peptides for CEND1 Gene

Domains for CEND1 Gene

Protein Domains for CEND1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N111

UniProtKB/Swiss-Prot:

CEND_HUMAN :
  • Q8N111
Family:
  • Belongs to the CEND1 family.
genes like me logo Genes that share domains with CEND1: view

No data available for Gene Families for CEND1 Gene

Function for CEND1 Gene

Molecular function for CEND1 Gene

UniProtKB/Swiss-Prot Function: Involved in neuroblastoma cell differentiation.

Phenotypes for CEND1 Gene

genes like me logo Genes that share phenotypes with CEND1: view

Animal Model Products

CRISPR Products

miRNA for CEND1 Gene

miRTarBase miRNAs that target CEND1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEND1 Gene

Localization for CEND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEND1 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEND1 Gene COMPARTMENTS Subcellular localization image for CEND1 gene
Compartment Confidence
nucleus 2
peroxisome 2
cytoskeleton 1
cytosol 1
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CEND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEND1: view

Pathways for CEND1 Gene

genes like me logo Genes that share pathways with CEND1: view

Pathways by source for CEND1 Gene

2 Cell Signaling Technology pathways for CEND1 Gene

Interacting Proteins for CEND1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000328336%0d%0a9606.ENSP00000275493%0d%0a9606.ENSP00000357292%0d%0a
Selected Interacting proteins: Q8N111-CEND_HUMAN ENSP00000328336 for CEND1 Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for CEND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007628 adult walking behavior IEA --
GO:0021686 cerebellar granular layer maturation IEA --
GO:0021702 cerebellar Purkinje cell differentiation IEA --
GO:0021933 radial glia guided migration of cerebellar granule cell IEA --
GO:0021941 negative regulation of cerebellar granule cell precursor proliferation IEA --
genes like me logo Genes that share ontologies with CEND1: view

Transcripts for CEND1 Gene

mRNA/cDNA for CEND1 Gene

(101) Selected AceView cDNA sequences:
(4) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEND1 Gene

Cell cycle exit and neuronal differentiation 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEND1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEND1 Gene

No ASD Table

Relevant External Links for CEND1 Gene

GeneLoc Exon Structure for
CEND1
ECgene alternative splicing isoforms for
CEND1

Expression for CEND1 Gene

mRNA expression in normal human tissues for CEND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEND1 Gene

This gene is overexpressed in Brain - Cortex (7.0), Brain - Frontal Cortex (BA9) (6.3), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Cerebellum (4.4), Brain - Hippocampus (4.1), and Brain - Cerebellar Hemisphere (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEND1 Gene

SOURCE GeneReport for Unigene cluster for CEND1 Gene Hs.22140

mRNA Expression by UniProt/SwissProt for CEND1 Gene

Q8N111-CEND_HUMAN
Tissue specificity: Neuron specific.
genes like me logo Genes that share expressions with CEND1: view

In Situ Assay Products

Orthologs for CEND1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEND1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEND1 35
  • 99.11 (n)
  • 98.66 (a)
CEND1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEND1 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEND1 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cend1 35
  • 82.19 (n)
  • 82.19 (a)
Cend1 16
Cend1 36
  • 79 (a)
OneToOne
Species with no ortholog for CEND1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEND1 Gene

ENSEMBL:
Gene Tree for CEND1 (if available)
TreeFam:
Gene Tree for CEND1 (if available)

Paralogs for CEND1 Gene

Pseudogenes.org Pseudogenes for CEND1 Gene

genes like me logo Genes that share paralogs with CEND1: view

No data available for Paralogs for CEND1 Gene

Variants for CEND1 Gene

Sequence variations from dbSNP and Humsavar for CEND1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs6597982 -- 788,007(-) ACATA(C/T)GCCCC utr-variant-3-prime
rs7111306 -- 786,684(-) CCGGC(C/G)GGCCT downstream-variant-500B
rs7483022 -- 787,571(-) GTGGG(A/C)AGACG utr-variant-3-prime
rs7946354 -- 787,679(-) TACCC(A/C)CCGGG utr-variant-3-prime
rs9943678 -- 786,953(+) GGTGG(C/G)GATCC downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CEND1 Gene

Variant ID Type Subtype PubMed ID
dgv182e199 CNV Deletion 23128226
dgv921n71 CNV Loss 21882294
nsv469923 CNV Loss 18288195
essv23843 CNV CNV 17122850
dgv936n71 CNV Loss 21882294
dgv944n71 CNV Loss 21882294
dgv945n71 CNV Loss 21882294
nsv896583 CNV Gain 21882294
dgv946n71 CNV Loss 21882294
nsv896587 CNV Loss 21882294
essv11734 CNV CNV 17122850
nsv8759 CNV Gain 18304495
dgv947n71 CNV Loss 21882294
dgv948n71 CNV Loss 21882294
nsv896599 CNV Loss 21882294

Relevant External Links for CEND1 Gene

HapMap Linkage Disequilibrium report
CEND1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEND1 Gene

Disorders for CEND1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CEND1 Gene including...

Search for CEND1 Gene in MalaCards »
genes like me logo Genes that share disorders with CEND1: view

No data available for UniProtKB/Swiss-Prot for CEND1 Gene

Publications for CEND1 Gene

  1. Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis. (PMID: 11311134) Gaitanou M. … Matsas R. (Biochem. J. 2001) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization of the BM88 promoter and identification of an 88 bp fragment sufficient to drive neurone-specific expression. (PMID: 16181419) Papadodima O. … Matsas R. (J. Neurochem. 2005) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CEND1 Gene

Sources for CEND1 Gene

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