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Aliases for CEND1 Gene

Aliases for CEND1 Gene

  • Cell Cycle Exit And Neuronal Differentiation 1 2 3 5
  • BM88 Antigen 3 4
  • BM88 3 4
  • Cell Cycle Exit And Neuronal Differentiation Protein 1 3

External Ids for CEND1 Gene

Previous GeneCards Identifiers for CEND1 Gene

  • GC11M000786
  • GC11M000603

Summaries for CEND1 Gene

Entrez Gene Summary for CEND1 Gene

  • The protein encoded by this gene is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEND1 Gene

CEND1 (Cell Cycle Exit And Neuronal Differentiation 1) is a Protein Coding gene. Diseases associated with CEND1 include Beckwith-Wiedemann Syndrome. Among its related pathways are DNA Damage and Neuroscience.

UniProtKB/Swiss-Prot for CEND1 Gene

  • Involved in neuronal differentiation.

Additional gene information for CEND1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEND1 Gene

Genomics for CEND1 Gene

Regulatory Elements for CEND1 Gene

Enhancers for CEND1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H000839 1.3 ENCODE dbSUPER 11.3 -53.7 -53655 7.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 ZNF143 ZNF207 CD151 TMEM80 PIDD1 SNORA52 RPLP2 TSPAN4 RIC8A ENSG00000255158 BET1L ENSG00000255237
GH11H000836 1.2 ENCODE dbSUPER 11.3 -48.1 -48073 2.8 MLX ARID4B SIN3A DMAP1 ZNF121 GLIS2 ZNF143 KLF7 SP3 SP5 CD151 RPLP2 SNORA52 PIDD1 SLC25A22 CEND1 AP2A2 PIR52875 GC11M000839
GH11H000654 1.1 FANTOM5 ENCODE 11.1 +134.8 134807 0.9 FOXA2 MLX ARID4B RAD21 RARA MIXL1 THAP11 CEBPB ZHX2 MXD4 TMEM80 CDHR5 EPS8L2 DEAF1 IRF7 TALDO1 ENSG00000255142 GATD1 LOC171391 CEND1
GH11H001051 1.1 ENCODE dbSUPER 10.2 -261.1 -261130 0.3 RB1 ARID4B KLF17 SIN3A ZNF2 RAD21 ZNF143 ZNF207 RUNX3 THAP11 MUC2 AP2A2 PIDD1 RPLP2 SLC25A22 CEND1 GC11P001047 PIR44225
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEND1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CEND1 Gene

Genomic Locations for CEND1 Gene
3,023 bases
Minus strand

Genomic View for CEND1 Gene

Genes around CEND1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEND1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEND1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEND1 Gene

Proteins for CEND1 Gene

  • Protein details for CEND1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell cycle exit and neuronal differentiation protein 1
    Protein Accession:
    Secondary Accessions:
    • Q9NYM6

    Protein attributes for CEND1 Gene

    149 amino acids
    Molecular mass:
    14954 Da
    Quaternary structure:
    • Homodimer (PubMed:11311134). Interacts with AHI1 (By similarity).

neXtProt entry for CEND1 Gene

Post-translational modifications for CEND1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEND1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CEND1 (CEND1)
  • Abcam antibodies for CEND1
  • Santa Cruz Biotechnology (SCBT) Antibodies for CEND1

No data available for DME Specific Peptides for CEND1 Gene

Domains & Families for CEND1 Gene

Gene Families for CEND1 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CEND1 Gene


Suggested Antigen Peptide Sequences for CEND1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CEND1 family.
  • Belongs to the CEND1 family.
genes like me logo Genes that share domains with CEND1: view

Function for CEND1 Gene

Molecular function for CEND1 Gene

UniProtKB/Swiss-Prot Function:
Involved in neuronal differentiation.

Phenotypes From GWAS Catalog for CEND1 Gene

genes like me logo Genes that share phenotypes with CEND1: view

Animal Models for CEND1 Gene

MGI Knock Outs for CEND1:

Animal Model Products

CRISPR Products

miRNA for CEND1 Gene

miRTarBase miRNAs that target CEND1

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEND1 Gene

Localization for CEND1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEND1 Gene

Membrane; Single-pass type IV membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEND1 gene
Compartment Confidence
peroxisome 2
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
cytosol 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CEND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEND1: view

Pathways & Interactions for CEND1 Gene

SuperPathways for CEND1 Gene

SuperPathway Contained pathways
1 DNA Damage
2 Neuroscience
genes like me logo Genes that share pathways with CEND1: view

Pathways by source for CEND1 Gene

2 Cell Signaling Technology pathways for CEND1 Gene

Interacting Proteins for CEND1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000328336 Q8N111-CEND_HUMAN for CEND1 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CEND1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007628 adult walking behavior IEA --
GO:0021549 cerebellum development IEA --
GO:0021686 cerebellar granular layer maturation IEA --
GO:0021702 cerebellar Purkinje cell differentiation IEA --
GO:0021933 radial glia guided migration of cerebellar granule cell IEA --
genes like me logo Genes that share ontologies with CEND1: view

No data available for SIGNOR curated interactions for CEND1 Gene

Drugs & Compounds for CEND1 Gene

No Compound Related Data Available

Transcripts for CEND1 Gene

mRNA/cDNA for CEND1 Gene

Unigene Clusters for CEND1 Gene

Cell cycle exit and neuronal differentiation 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEND1 Gene

No ASD Table

Relevant External Links for CEND1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEND1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEND1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEND1 Gene

This gene is overexpressed in Brain - Cortex (x7.0), Brain - Frontal Cortex (BA9) (x6.3), Brain - Anterior cingulate cortex (BA24) (x5.5), Brain - Cerebellum (x4.4), Brain - Hippocampus (x4.1), and Brain - Cerebellar Hemisphere (x4.0).

Protein differential expression in normal tissues from HIPED for CEND1 Gene

This gene is overexpressed in Frontal cortex (35.9) and Brain (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CEND1 Gene

Protein tissue co-expression partners for CEND1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEND1 Gene:


SOURCE GeneReport for Unigene cluster for CEND1 Gene:


mRNA Expression by UniProt/SwissProt for CEND1 Gene:

Tissue specificity: Neuron specific.

Evidence on tissue expression from TISSUES for CEND1 Gene

  • Nervous system(4.9)
  • Lung(4)
genes like me logo Genes that share expression patterns with CEND1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CEND1 Gene

Orthologs for CEND1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEND1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CEND1 33 34
  • 99.11 (n)
(Mus musculus)
Mammalia Cend1 33 16 34
  • 82.19 (n)
(Canis familiaris)
Mammalia CEND1 34
  • 79 (a)
(Bos Taurus)
Mammalia CEND1 34
  • 75 (a)
Species where no ortholog for CEND1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEND1 Gene

Gene Tree for CEND1 (if available)
Gene Tree for CEND1 (if available)

Paralogs for CEND1 Gene Pseudogenes for CEND1 Gene

genes like me logo Genes that share paralogs with CEND1: view

No data available for Paralogs for CEND1 Gene

Variants for CEND1 Gene

Sequence variations from dbSNP and Humsavar for CEND1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs112476979 Likely benign 791,479(+) GAGCC(A/G)CTTGG upstream-variant-2KB, utr-variant-3-prime
rs118051043 Likely benign 791,009(+) ATGCC(C/T)GCCCT upstream-variant-2KB, utr-variant-3-prime
rs139577104 Likely benign 791,209(+) GCATG(-/CA)GCACA upstream-variant-2KB, utr-variant-3-prime
rs17156064 Likely benign 790,762(-) TGCCC(C/T)GCCCT upstream-variant-2KB, utr-variant-3-prime
rs554507285 Likely benign 791,898(+) TGGGG(G/T)GGAGC upstream-variant-2KB, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEND1 Gene

Variant ID Type Subtype PubMed ID
nsv951272 CNV deletion 24416366
nsv8759 CNV gain 18304495
nsv552871 CNV loss 21841781
nsv552870 CNV loss 21841781
nsv469923 CNV loss 18288195
nsv1159791 CNV deletion 26073780
nsv1069539 CNV deletion 25765185
nsv1040044 CNV gain+loss 25217958
esv2759794 CNV loss 17122850
dgv182e199 CNV deletion 23128226
dgv1013n100 CNV gain 25217958

Variation tolerance for CEND1 Gene

Residual Variation Intolerance Score: 50.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.53; 11.52% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEND1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEND1 Gene

Disorders for CEND1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CEND1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
beckwith-wiedemann syndrome
  • wiedemann-beckwith syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CEND1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CEND1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CEND1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEND1 Gene

Publications for CEND1 Gene

  1. Cloning, expression and localization of human BM88 shows that it maps to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and tumorigenesis. (PMID: 11311134) Gaitanou M … Matsas R (The Biochemical journal 2001) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PMID: 23864651) Huang X … Wheeler MB (Molecular endocrinology (Baltimore, Md.) 2013) 3 60
  5. Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6. (PMID: 20029029) Deribe YL … Dikic I (Science signaling 2009) 3 60

Products for CEND1 Gene

Sources for CEND1 Gene

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