CEMP1 Gene
protein-coding GIFtS: 36
GCID: GC16M002518
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cementum protein 1
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Aliases
for CEMP1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Cementum Protein 11 2 3 | | CP-231 2 3 | | CP232 3 5 | | Cementum Protein 232 3 | | Cementoblastoma-Derived Protein 12 | | Cementum Protein-232 |
Export aliases for CEMP1 gene to outside databases |
Summaries
for CEMP1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CEMP1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010393.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CEMP1 gene promoter:
FOXF2 CUTL1 Tal-1beta E47 YY1 MZF-1 POU2F1 POU2F1a ARP-1 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEMP1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEMP1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3CEMP1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M002518: view genomic region
(about GC identifiers)
Start:
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2,577,081 bp from pter |
End:
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2,594,077 bp from pter |
Size:
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16,997 bases |
Orientation:
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minus strand |
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Proteins
for CEMP1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEMP1_HUMAN, Q6PRD7 (See
protein sequence)Recommended Name: Cementoblastoma-derived protein 1 Size: 247 amino acids; 25959 Da
Subcellular location: Cytoplasm
Secondary accessions: B2RUY1Explore the universe of human proteins at neXtProt for CEMP1: NX_Q6PRD7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PRD7
CEMP1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001041677.1
ENSEMBL proteins: ENSP00000457380 ENSP00000455479 ENSP00000371787
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005737 | cytoplasm |
IEA | -- |
CEMP1 for ontologies About GeneDecksing
CEMP1 Antibody Products:
Assay Products for CEMP1: |
Protein
Domains /
Families
for CEMP1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q6PRD7 |
Function
for CEMP1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEMP1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEMP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CEMP1 (NM_001048212) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEMP1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEMP1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEMP1 |
|
Pathways & Interactions
for CEMP1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEMP1
|
Drugs & Compounds
for CEMP1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEMP1
Search CenterWatch for drugs/clinical trials and news about CEMP1
|
Transcripts
for CEMP1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEMP1 gene: NM_001048212.3 Unigene Cluster for CEMP1: Cementum protein 1 Hs.743305 [show with all ESTs]Unigene Representative Sequence: AL8330993 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000567119(uc002cqr.3) ENST00000565480 ENST00000382350
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEMP1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEMP1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CEMP1 (NM_001048212) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEMP1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEMP1 |
Additional cDNA sequence: AL833099.1 AY584596.1 BC146925.1 BC146926.1 6 DOTS entries: DT.414015 DT.455139 DT.95089959 DT.100028439 DT.100000052 DT.65285095
GeneLoc Exon Structure
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Expression
for CEMP1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEMP1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CEMP1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEMP1
SOURCE GeneReport for Unigene cluster: Hs.743305
UniProtKB/Swiss-Prot: CEMP1_HUMAN, Q6PRD7Tissue specificity: Detected in periodontal ligament, cementum, cementoblasts and cementoblastoma
SABiosciences Custom PCR Arrays for CEMP1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEMP1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CEMP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEMP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEMP1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEMP1 |
Orthologs
for CEMP1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for CEMP1 (if available)
TreeFam Gene Tree for CEMP1 (if available) |
Paralogs
for CEMP1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CEMP1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEMP1 (2577081 - 2594077 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CEMP1
3 CNVs: 4918 3988 5329 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CEMP1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEMP1 for disorders About GeneDecksing
OMIM gene information: 611113
OMIM disorders: --
5  diseases for CEMP1: About MalaCardscryptosporidiosis thymic carcinoma gingivitis periodontitis
carcinoma
1 disease from the University of Copenhagen DISEASES database for CEMP1:Cryptosporidiosis Export disorders for CEMP1 gene to outside databases
|
Publications
for CEMP1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEMP1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CEMP1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning, expression and immunolocalization of a novel human cementum-derived protein (CP-23). (PubMed id 16263347)1, 2, 3 Alvarez-Perez M.A.... Arzate H. (2006)
- The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
- Human primary cementoblasts respond to combined IL-1b stimulation and compression with an impaired BSP and CEMP-1 expression. (PubMed id 22349547)1 Diercke K....Erber R. (2012)
- Cementum protein 1 (CEMP1) induces a cementoblastic p henotype and reduces osteoblastic differentiation in periodontal ligament cells . (PubMed id 21465469)1 Komaki M....Morita I. (2012)
- Characterization of recombinant human cementum protei n 1 (hrCEMP1): primary role in biomineralization. (PubMed id 19393626)1 Villarreal-RamA-rez E....Arzate H. (2009)
- Human Cementum Protein 1 induces expression of bone and cementum proteins by human gingival fibroblasts. (PubMed id 17509525)1 Carmona-Rodriguez B....Arzate H. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for CEMP1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing CEMP1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEMP1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEMP1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEMP1 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for CEMP1 gene:
Search GeneIP for patents involving CEMP1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEMP1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CEMP1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEMP1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEMP1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CEMP1 | | OriGene 3'-UTR Clone for CEMP1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEMP1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEMP1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CEMP1 | | OriGene Custom Protein Services for CEMP1 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEMP1 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEMP1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEMP1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEMP1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEMP1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEMP1 |
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| | | | Search Tocris compounds for CEMP1 |
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 | | | CEMP1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEMP1 |
|  |  |  | | | | Search ThermoFisher Antibodies for CEMP1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEMP1 |
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