Aliases for CEMIP Gene
External Ids for CEMIP Gene
Previous Symbols for CEMIP Gene
GeneCards Summary for CEMIP Gene
CEMIP (Cell Migration Inducing Protein, Hyaluronan Binding) is a Protein Coding gene. An important paralog of this gene is PKHD1.
UniProtKB/Swiss-Prot for CEMIP Gene
Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.