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Aliases for CEMIP Gene

Aliases for CEMIP Gene

  • Cell Migration Inducing Protein, Hyaluronan Binding 2 3
  • KIAA1199 2 3 4 6
  • Cell Migration-Inducing And Hyaluronan-Binding Protein 3
  • Colon Cancer Secreted Protein 1 3
  • EC 3.2.1.35 4
  • TMEM2L 3
  • CCSP1 3

External Ids for CEMIP Gene

Previous HGNC Symbols for CEMIP Gene

  • KIAA1199

Previous GeneCards Identifiers for CEMIP Gene

  • GC15P081072

Summaries for CEMIP Gene

GeneCards Summary for CEMIP Gene

CEMIP (Cell Migration Inducing Protein, Hyaluronan Binding) is a Protein Coding gene. An important paralog of this gene is PKHD1.

UniProtKB/Swiss-Prot for CEMIP Gene

  • Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.

Gene Wiki entry for CEMIP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEMIP Gene

Genomics for CEMIP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CEMIP Gene

Start:
80,779,343 bp from pter
End:
80,951,776 bp from pter
Size:
172,434 bases
Orientation:
Plus strand

Genomic View for CEMIP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEMIP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEMIP Gene

No data available for Regulatory Elements for CEMIP Gene

Proteins for CEMIP Gene

  • Protein details for CEMIP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUJ3-CEMIP_HUMAN
    Recommended name:
    Cell migration-inducing and hyaluronan-binding protein
    Protein Accession:
    Q8WUJ3
    Secondary Accessions:
    • Q6L9J5
    • Q9H1K5
    • Q9NPN9
    • Q9ULM1

    Protein attributes for CEMIP Gene

    Size:
    1361 amino acids
    Molecular mass:
    152998 Da
    Quaternary structure:
    • Interacts with EPHA2 and ITPR3. Interacts with HSPA5/BIP; the interaction induces calcium leakage from the endoplasmic reticulum and cell migration. Interacts with clathrin heavy chain/CLTC.

    Alternative splice isoforms for CEMIP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEMIP Gene

Proteomics data for CEMIP Gene at MOPED

Post-translational modifications for CEMIP Gene

  • N-glycosylated; glycosylation is not necessary for HA-binding.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CEMIP Gene

Domains for CEMIP Gene

Protein Domains for CEMIP Gene

Graphical View of Domain Structure for InterPro Entry

Q8WUJ3

UniProtKB/Swiss-Prot:

CEMIP_HUMAN :
  • Q8WUJ3
Domain:
  • The signal sequence is essential in mediating its proper translocation, hyaluronic acid (HA) degradation activity and secretion
  • Contains 1 G8 domain.
Family:
  • Belongs to the TMEM2 family.
Similarity:
  • Contains 4 PbH1 repeats.
genes like me logo Genes that share domains with CEMIP: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CEMIP Gene

Function for CEMIP Gene

Molecular function for CEMIP Gene

UniProtKB/Swiss-Prot CatalyticActivity: Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
UniProtKB/Swiss-Prot EnzymeRegulation: Activity is up-regulated by histamine.
UniProtKB/Swiss-Prot Function: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.
UniProtKB/Swiss-Prot Induction: Up-regulated by histamine. Up-regulated by the adapter protein complex 1 (AP-1) and NF-kappaB/RELA. Down-regulated by transforming growth factor TGFB1.

Enzyme Numbers (IUBMB) for CEMIP Gene

Gene Ontology (GO) - Molecular Function for CEMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004415 hyalurononglucosaminidase activity IDA 23509262
GO:0005515 protein binding IPI 23990668
GO:0005540 hyaluronic acid binding IDA 23509262
GO:0032050 clathrin heavy chain binding IDA 23509262
GO:0046923 ER retention sequence binding IDA 23990668
genes like me logo Genes that share ontologies with CEMIP: view

Animal Model Products

CRISPR Products

miRNA for CEMIP Gene

miRTarBase miRNAs that target CEMIP

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEMIP Gene

Localization for CEMIP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEMIP Gene

Nucleus. Cytoplasm. Endoplasmic reticulum. Cell membrane. Membrane, clathrin-coated pit. Secreted. Note=Retained in the endoplasmic reticulum (ER) in a HSPA5/BIP-dependent manner. Colocalized with clathrin heavy chain/CLTC in clathrin-coated vesicles. Strongly detected in the cytoplasm of breast carcinoma cells, whereas poorly detected in adjacent normal epithelial cells, stromal cells, or benign breast tissues. Localized in the nucleus and cytoplasm of colon adenocarcinomas.

Gene Ontology (GO) - Cellular Components for CEMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IMP 14577002
GO:0005783 endoplasmic reticulum IDA 23990668
GO:0005886 plasma membrane IDA 23509262
genes like me logo Genes that share ontologies with CEMIP: view

No data available for Subcellular locations from COMPARTMENTS for CEMIP Gene

Pathways for CEMIP Gene

SuperPathways for CEMIP Gene

No Data Available

Interacting Proteins for CEMIP Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000220244%0d%0a9606.ENSP00000356000%0d%0a9606.ENSP00000317128%0d%0a
Selected Interacting proteins: ENSP00000220244 Q8WUJ3-CEMIP_HUMAN for CEMIP Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CEMIP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IMP 14577002
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 23990668
GO:0030214 hyaluronan catabolic process IMP 23509262
GO:0030335 positive regulation of cell migration IDA 23990668
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol IDA 23990668
genes like me logo Genes that share ontologies with CEMIP: view

No data available for Pathways by source for CEMIP Gene

Transcripts for CEMIP Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEMIP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CEMIP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEMIP Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:

ExUns: 21b ^ 22 ^ 23a · 23b · 23c ^ 24a · 24b · 24c ^ 25a · 25b ^ 26 ^ 27a · 27b · 27c ^ 28 ^ 29
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14: - -

Relevant External Links for CEMIP Gene

GeneLoc Exon Structure for
CEMIP
ECgene alternative splicing isoforms for
CEMIP

Expression for CEMIP Gene

mRNA expression in normal human tissues for CEMIP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CEMIP Gene

mRNA Expression by UniProt/SwissProt for CEMIP Gene

Q8WUJ3-CEMIP_HUMAN
Tissue specificity: Expressed in dermal and in synovial fibroblasts. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in both ductal carcinoma and invasive breast cancer cells compared with benign epithelial cells (at protein level). Strongly expressed in brain, placenta, prostate, breast, lung and testis. Expressed in fibroblasts, epithelial cells and cancer cells. In ear, it is specifically expressed in inner ear. Expressed in cochlea and vestibule tissues. Strongly expressed in gastric cancers compared with the paired normal tissues. Strongly expressed in colon adenocarcinomas compared with normal colonic mucosas. Strongly expressed in breast cancer as compared to normal breast tissue.
genes like me logo Genes that share expressions with CEMIP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CEMIP Gene

Orthologs for CEMIP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEMIP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1199 35
  • 99.49 (n)
  • 99.34 (a)
KIAA1199 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KIAA1199 35
  • 88.73 (n)
  • 91.4 (a)
KIAA1199 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1199 35
  • 87.78 (n)
  • 90.01 (a)
KIAA1199 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 9930013L23Rik 35
  • 86.85 (n)
  • 91.26 (a)
9930013L23Rik 16
9930013L23Rik 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KIAA1199 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1199 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305254 35
  • 86.02 (n)
  • 90.96 (a)
chicken
(Gallus gallus)
Aves KIAA1199 35
  • 74.79 (n)
  • 76.99 (a)
KIAA1199 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1199 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1199 35
  • 68.58 (n)
  • 70.05 (a)
zebrafish
(Danio rerio)
Actinopterygii BX897684.1 36
  • 68 (a)
OneToMany
Dr.10025 35
KIAA1199 (2 of 2) 36
  • 59 (a)
OneToMany
LOC100003660 35
  • 67.06 (n)
  • 67.15 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3786 36
  • 6 (a)
OneToMany
Species with no ortholog for CEMIP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEMIP Gene

ENSEMBL:
Gene Tree for CEMIP (if available)
TreeFam:
Gene Tree for CEMIP (if available)

Paralogs for CEMIP Gene

Paralogs for CEMIP Gene

genes like me logo Genes that share paralogs with CEMIP: view

Variants for CEMIP Gene

Sequence variations from dbSNP and Humsavar for CEMIP Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs813 -- 80,831,596(+) CAGCC(C/T)CTCTG intron-variant
rs815 -- 80,831,595(+) CCAGC(C/T)CCTCT intron-variant
rs25431 -- 80,838,546(+) TTGAA(A/G)TTCCC intron-variant
rs748696 -- 80,801,547(+) CTTTT(A/G)GCTGA intron-variant
rs750570 -- 80,806,166(-) CATAC(G/T)TTGGT intron-variant

Relevant External Links for CEMIP Gene

HapMap Linkage Disequilibrium report
CEMIP
Human Gene Mutation Database (HGMD)
CEMIP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEMIP Gene

Disorders for CEMIP Gene

No disorders were found for CEMIP Gene.

No data available for UniProtKB/Swiss-Prot for CEMIP Gene

Publications for CEMIP Gene

  1. Mutations in the gene encoding KIAA1199 protein, an inner-ear protein expressed in Deiters' cells and the fibrocytes, as the cause of nonsyndromic hearing loss. (PMID: 14577002) Abe S. … Nakamura Y. (J. Hum. Genet. 2003) 2 3 4
  2. Upregulation of the KIAA1199 gene is associated with cellular mortality. (PMID: 16157444) Michishita E. … Horikawa I. (Cancer Lett. 2006) 2 3 4
  3. Repression of KIAA1199 attenuates Wnt-signalling and decreases the proliferation of colon cancer cells. (PMID: 21772334) Birkenkamp-Demtroder K. … A9rntoft T.F. (Br. J. Cancer 2011) 3 4
  4. Clinicopathologic significance of KIAA1199 overexpression in human gastric cancer. (PMID: 19434458) Matsuzaki S. … Mori M. (Ann. Surg. Oncol. 2009) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for CEMIP Gene

Sources for CEMIP Gene

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