Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CELSR3 Gene

protein-coding   GIFtS: 55
GCID: GC03M048673

Cadherin, EGF LAG Seven-Pass G-Type Receptor 3

(Previous names: cadherin EGF LAG seven-pass G-type receptor 3, flamingo...)
(Previous symbol: EGFL1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cadherin, EGF LAG Seven-Pass G-Type Receptor 31 2     Cadherin EGF LAG Seven-Pass G-Type Receptor 3, Flamingo (Drosophila)
Homolog1
EGFL11 2 3 5     Flamingo Homolog 1 (Drosophila)1
MEGF22 3 5     HFMI12
Cadherin Family Member 112 3     RESDA12
Epidermal Growth Factor-Like Protein 12 3     Anchor Protein2
Flamingo Homolog 12 3     Cadherin EGF LAG Seven-Pass G-Type Receptor 32
Multiple EGF-Like Domains Protein 22 3     Cadherin, EGF LAG Seven-Pass G-Type Receptor 3 (Flamingo Homolog,
Drosophila)2
Multiple Epidermal Growth Factor-Like Domains Protein 22 3     EGF-Like-Domain, Multiple 12
CDHF112 3     KIAA08123
FMI12 3     hFmi13
EGF-Like Protein 12 3     

External Ids:    HGNC: 32301   Entrez Gene: 19512   Ensembl: ENSG000000083007   OMIM: 6042645   UniProtKB: Q9NYQ73   

Export aliases for CELSR3 gene to outside databases

Previous GC identifers: GC03M048463 GC03M047956 GC03M048493 GC03M048634 GC03M048638 GC03M048648


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CELSR3 Gene:
This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins
consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins
containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in
their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The
encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in
tumor formation. (provided by RefSeq, Jun 2013)

GeneCards Summary for CELSR3 Gene: 
CELSR3 (cadherin, EGF LAG seven-pass G-type receptor 3) is a protein-coding gene. Diseases associated with CELSR3 include strabismus, and neuronitis. GO annotations related to this gene include G-protein coupled receptor activity and calcium ion binding. An important paralog of this gene is DCHS1.

UniProtKB/Swiss-Prot: CELR3_HUMAN, Q9NYQ7
Function: Receptor that may have an important role in cell/cell signaling during nervous system formation

Gene Wiki entry for CELSR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.2  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CELSR3 gene promoter:
         AP-1   p53   ATF-2   NRSF form 1   c-Jun   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELSR3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CELSR3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELSR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21.31   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21.31

CELSR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELSR3 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M048673:  view genomic region     (about GC identifiers)

Start:
48,673,896 bp from pter      End:
48,700,348 bp from pter
Size:
26,453 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CELR3_HUMAN, Q9NYQ7 (See protein sequence)
Recommended Name: Cadherin EGF LAG seven-pass G-type receptor 3 precursor  
Size: 3312 amino acids; 358185 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: O75092
Alternative splicing: 2 isoforms:  Q9NYQ7-1   Q9NYQ7-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CELSR3: NX_Q9NYQ7

Explore proteomics data for CELSR3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYQ7

  • CELSR3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CELSR3 Protein Expression
    REFSEQ proteins: NP_001398.2  
    ENSEMBL proteins: 
     ENSP00000164024   ENSP00000445694  

    Human Recombinant Protein Products for CELSR3: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CELSR3
    GenScript Custom Purified and Recombinant Proteins Services for CELSR3
    Novus Biologicals CELSR3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CELSR3 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016020membrane ----
    GO:0016021integral to membrane IEA--

    CELSR3 for ontologies           About GeneDecksing



    CELSR3 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CELSR3
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CELSR3
    GenScript Custom Superior Antibodies Services for CELSR3
    Novus Biologicals CELSR3 Antibodies
    Search for Antibodies for CELSR3 at Abcam
    Cloud-Clone Corp. Antibodies for CELSR3 
    ThermoFisher Antibodies for CELSR3
    LSBio Antibodies in human, mouse, rat for CELSR3 

    Assay Products for CELSR3: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CELSR3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CELSR3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CELSR3 
    Cloud-Clone Corp. CLIAs for CELSR3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    GPCRBO: GPCR / Class B : Orphans
    MCDH: Cadherins / Major cadherins

    IUPHAR Guide to PHARMACOLOGY protein family classification: CELSR3 
    Adhesion Class GPCRs

    5/15 InterPro protein domains (see all 15):
     IPR000742 EG-like_dom
     IPR013320 ConA-like_subgrp
     IPR001879 GPCR_2_extracellular_dom
     IPR001791 Laminin_G
     IPR015919 Cadherin-like

    Graphical View of Domain Structure for InterPro Entry Q9NYQ7

    ProtoNet protein and cluster: Q9NYQ7

    5/8 Blocks protein domains (see all 8):
    IPB000152 Aspartic acid and asparagine hydroxylation site
    IPB000203 GPS domain
    IPB000832 G-protein coupled receptors family 2 (secretin-like)
    IPB001791 Laminin G
    IPB001881 EGF-like calcium-binding


    UniProtKB/Swiss-Prot: CELR3_HUMAN, Q9NYQ7
    Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily
    Similarity: Contains 9 cadherin domains
    Similarity: Contains 8 EGF-like domains
    Similarity: Contains 1 GPS domain
    Similarity: Contains 1 laminin EGF-like domain
    Similarity: Contains 2 laminin G-like domains


    CELSR3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CELR3_HUMAN, Q9NYQ7
    Function: Receptor that may have an important role in cell/cell signaling during nervous system formation

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004888transmembrane signaling receptor activity ----
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI17474147
         
    CELSR3 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Celsr3):
     behavior/neurological  cellular  digestive/alimentary  growth/size  homeostasis/metabolism 
     mortality/aging  nervous system  respiratory system 

    CELSR3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Celsr3tm1Agof for CELSR3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CELSR3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CELSR3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CELSR3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CELSR3 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CELSR3
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate CELSR3 (see all 54):
    hsa-miR-3938 hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-548m hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCELSR3 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CELSR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELSR3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CELSR3


    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CELSR3 (see all 5)
    OriGene ORF clones in mouse, rat for CELSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CELSR3 (NM_001407)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CELSR3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CELSR3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CELSR3
    Search LifeMap BioReagents cell lines for CELSR3
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELSR3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CELSR3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1GPCRs, Other
    GPCRs, Other


    1 BioSystems Pathway for CELSR3
        GPCRs, Other


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELSR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/23 Interacting proteins for CELSR3 (Q9NYQ71, 2, 3 ENSP000001640244) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABL1P005192, 3, ENSP000003614234MINT-8110119 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8111031 I2D: score=3 STRING: ENSP00000357656
    SGSM2O431472, 3MINT-64875 I2D: score=5 
    NCK1P163331, 3, ENSP000002889864EBI-308417,EBI-389883 I2D: score=2 STRING: ENSP00000288986
    CLUHO751533, ENSP000003888724I2D: score=3 STRING: ENSP00000388872
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001764neuron migration IEA--
    GO:0007156homophilic cell adhesion IEA--
    GO:0007166cell surface receptor signaling pathway ----
    GO:0007186G-protein coupled receptor signaling pathway TAS15203201
    GO:0007218neuropeptide signaling pathway IEA--

    CELSR3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CELSR3 (CELR3)

    Search CenterWatch for drugs/clinical trials and news about CELSR3 / CELR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CELSR3 gene: 
    NM_001407.2  

    Unigene Cluster for CELSR3:

    Cadherin, EGF LAG seven-pass G-type receptor 3
    Hs.631926  [show with all ESTs]
    Unigene Representative Sequence: NM_001407
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000164024(uc003cuf.1 uc003cul.3) ENST00000461362(uc010hkf.3)
    ENST00000498057 ENST00000470999 ENST00000544264(uc010hkg.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CELSR3
    8/54 QIAGEN miScript miRNA Assays for microRNAs that regulate CELSR3 (see all 54):
    hsa-miR-3938 hsa-miR-3607-3p hsa-miR-330-5p hsa-miR-30d hsa-miR-29b-1* hsa-miR-548m hsa-miR-1184 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCELSR3 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CELSR3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELSR3
    Clone
    Products:
         
    OriGene clones in human, mouse for CELSR3 (see all 5)
    OriGene ORF clones in mouse, rat for CELSR3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CELSR3 (NM_001407)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CELSR3
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CELSR3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CELSR3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CELSR3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELSR3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELSR3

    Additional mRNA sequence: 

    AB011536.1 AF231023.1 AK299868.1 BC130010.1 

    6 DOTS entries:

    DT.309556  DT.40311184  DT.305126  DT.120911015  DT.91672744  DT.95149315 

    24/71 AceView cDNA sequences (see all 71):

    BU739303 BE858103 BM712531 BQ056846 BU738328 BM714676 AW590676 BM674265 
    AI926277 BM673813 AB011536 BM555126 AW770479 BE467095 BE503784 BM665242 
    BU538638 BM749965 AI359223 BX091306 BQ063063 BE044324 BE219413 AA773736 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CELSR3 (see all 22)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36a · 36b · 36c ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40a · 40b · 40c ^ 41a · 41b ·
    SP1:                                      -     -                                                                                                               
    SP2:                                                                                                  -     -                       -                           
    SP3:                                                                                                  -     -                       -                           
    SP4:                                                                                                  -     -                                                   
    SP5:                                                                                                  -     -                       -                           

    ExUns: 41c · 41d ^ 42a · 42b ^ 43a · 43b · 43c ^ 44a · 44b · 44c · 44d ^ 45a · 45b ^ 46a · 46b ^ 47a · 47b · 47c ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53a · 53b · 53c ^
    SP1:                                                                                                                                                            
    SP2:                                            -     -                                                                       -                             -   
    SP3:                                            -     -                                                                       -                             -   
    SP4:                                            -     -                                                                       -                                 
    SP5:                                            -     -                                                                       -                                 

    ExUns: 54a · 54b · 54c ^ 55a · 55b · 55c · 55d ^ 56 ^ 57 ^ 58a ·
    SP1:                                                            
    SP2:  -           -     -     -                                 
    SP3:  -           -     -     -                                 
    SP4:  -     -     -     -                                       
    SP5:  -     -     -     -                                       


    ECgene alternative splicing isoforms for CELSR3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CELSR3 expression in normal human tissues (normalized intensities)      CELSR3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATACTCTTG
    CELSR3 Expression
    About this image


    CELSR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Neuron (Nervous System)    fully expand to see all 2 entries
             Human Neurons   
     
     Brain (Nervous System)    fully expand to see all 2 entries
             cerebellum   
     
     Neural Ectoderm (Nervous System)
             Neural Plate
     
     Neural Tube (Nervous System)
             Spinal Dorsal Columns
     
     Epidermis (Integumentary System)

    See CELSR3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CELSR3

    SOURCE GeneReport for Unigene cluster: Hs.631926
        SABiosciences Expression via Pathway-Focused PCR Array including CELSR3: 
              G Protein Coupled Receptors 384HT in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CELSR3
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CELSR3
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELSR3
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELSR3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELSR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CELSR3 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Celsr31 , 5 cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo more1, 5 87.08(n)1
    92.69(a)1
      9 (59.63 cM)5
    1079341  NM_080437.21  NP_536685.21 
     1088263205 
    chicken
    (Gallus gallus)
    Aves CELSR36
    Cadherin; Uncharacterized protein
    73(a)
    1 ↔ 1
    12(9012888-9036163)
    lizard
    (Anolis carolinensis)
    Reptilia CELSR36
    cadherin, EGF LAG seven-pass G-type receptor 3
    61(a)
    1 ↔ 1
    2(164254121-164356861)
    zebrafish
    (Danio rerio)
    Actinopterygii celsr31 cadherin, EGF LAG seven-pass G-type receptor 3 65.08(n)
    67.04(a)
      100008568  XM_001922677.4  XP_001922712.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta stan3 dendrite morphogenesis transmembrane
    receptor
    42(a)
    (best of 4)
        --
    worm
    (Caenorhabditis elegans)
    Secernentea fmi-16
    Protein FMI-1
    23(a)
    1 → many
    V(13019068-13033399)


    ENSEMBL Gene Tree for CELSR3 (if available)
    TreeFam Gene Tree for CELSR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CELSR3 gene
    DCHS12  CDHR22  DCHS22  CELSR12  FAT22  CDHR12  PCDH152  FAT42  
    FAT32  CELSR22  FAT12  
    15 SIMAP similar genes for CELSR3 using alignment to 2 protein entries:     CELR3_HUMAN (see all proteins):
    RESDA1    CELSR2    F9    CELSR1    FLJ00015    ME5
    FAT3    FLJ00046    ELTD1    ME2    ME6    FLJ00233
    ME1    ME3    DKFZp434P2350

    CELSR3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/693 SNPs in CELSR3 are shown (see all 693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1491325601,2
    C,Funtested148696750(+) TCCACG/AATCTG 2 /I syn11Minor allele frequency- A:0.01NA 4552
    rs67732611,2
    C,F,A,H--48675064(+) TGAGCA/GAGCCC 1 -- ut31 ese319Minor allele frequency- N:0.00EA NA NS WA CSA 976
    rs68092051,2
    C,F--48675159(+) AAGAAC/AAATTC 1 -- ut31 ese31Minor allele frequency- A:0.04WA 118
    rs1146311301,2
    C,F--48675351(+) AGCCTC/TAAACC 1 -- ut311Minor allele frequency- T:0.04WA 118
    rs1138628261,2
    F--48675420(+) AAAACG/ATATAA 1 -- ut311Minor allele frequency- A:0.50CSA 2
    rs1471080341,2
    C--48675603(+) CTGTCA/GCCCTC 1 -- ut310--------
    rs2002755111,2
    C--48675629(+) ACGCCA/GTCATC 1 -- ut310--------
    rs2019212181,2
    --48675676(+) GGCACA/GTGAGG 1 -- int10--------
    rs2015028231,2
    --48675704(+) CCAGAA/GGACTC 1 -- int10--------
    rs1148993271,2
    C,F--48675839(+) ATTCCG/ACGCCC 1 -- int11Minor allele frequency- A:0.03NA 120

    HapMap Linkage Disequilibrium report for CELSR3 (48673896 - 48700348 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CELSR3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv876762CNV Loss21882294
    nsv834685CNV Loss17160897
    nsv876763CNV Loss21882294
    nsv523981CNV Loss19592680
    nsv818138CNV Gain17921354
    nsv822075CNV Gain20364138

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CELSR3
    DNA2.0 Custom Variant and Variant Library Synthesis for CELSR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604264    OMIM disorders: --

    2 diseases for CELSR3:    About MalaCards
    strabismus    neuronitis


    CELSR3 for disorders           About GeneDecksing


    Export disorders for CELSR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CELSR3 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with CELSR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PubMed id 9693030)1, 2, 3 Nakayama M.... Ohara O. (1998)
    2. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)1, 2 Wu Q. and Maniatis T. (2000)
    3. Mindbomb 1, an E3 ubiquitin ligase, forms a complex w ith RYK to activate Wnt/I^-catenin signaling. (PubMed id 21875946)1 Berndt J.D....Moon R.T. (2011)
    4. Organ-, inflammation- and cancer specific transcripti onal fingerprints of pancreatic and hepatic stellate cells. (PubMed id 20416094)1 Erkan M....Kleeff J. (2010)
    5. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    6. Opposing roles in neurite growth control by two seven- pass transmembrane cadherins. (PubMed id 17618280)1 Shima Y....Uemura T. (2007)
    7. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    8. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
    9. A human protein-protein interaction network: a resource for annotating the proteome. (PubMed id 16169070)1 Stelzl U.... Wanker E.E. (2005)
    10. WNT/PCP signaling pathway and human cancer (review). (PubMed id 16273260)1 Katoh M. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1951 HGNC: 3230 AceView: UQCRC1 Ensembl:ENSG00000008300 euGenes: HUgn1951
    ECgene: CELSR3 H-InvDB: CELSR3

    (According to HUGE)
    About This Section
    HUGE: KIAA0812

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CELSR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CELSR3 gene:
    Search GeneIP for patents involving CELSR3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CELSR3 (CELSR3)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CELSR3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CELSR3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CELSR3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CELSR3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CELSR3   OriGene Custom Protein Services for CELSR3  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CELSR3
     QIAGEN SeqTarget long-range PCR primers for resequencing CELSR3
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELSR3
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELSR3
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELSR3
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELSR3
     GenScript Custom Purified and Recombinant Proteins Services for CELSR3 GenScript cDNA clones with any tag delivered in your preferred vector for CELSR3
     GenScript Custom Assay Services for CELSR3 GenScript Custom Superior Antibodies Services for CELSR3
     GenScript Custom overexpressing Cell Line Services for CELSR3 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CELSR3 promoter
     Search Chromatin IP Primers for CELSR3
     RT2 qPCR Primer Assay in human, mouse, rat CELSR3
     Search GNC Networks for CELSR3
     SABiosciences PCR Arrays including human, mouse, rat CELSR3
     Search Tocris compounds for CELSR3 (CELR3)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CELSR3 antibodies
     CELSR3 proteins
     Search for Antibodies for CELSR3 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CELSR3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CELSR3
     Antibodies for CELSR3
     ELISAs for CELSR3
     CLIAs for CELSR3
     Search LifeMap BioReagents cell lines for CELSR3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELSR3
     SwitchGear 3'UTR luciferase reporter plasmids for CELSR3
     SwitchGear Promoter luciferase reporter plasmids for CELSR3
     ThermoFisher Antibodies for CELSR3
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CELSR3
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CELSR3
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CELSR3
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression
     LSBio Antibodies in human, mouse, rat for CELSR3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CELSR3 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4