Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CELSR3 Gene

Aliases for CELSR3 Gene

  • Cadherin EGF LAG Seven-Pass G-Type Receptor 3 2 3
  • Multiple Epidermal Growth Factor-Like Domains Protein 2 3 4
  • Cadherin, EGF LAG Seven-Pass G-Type Receptor 3 2 5
  • Adhesion G Protein-Coupled Receptor C3 2 3
  • Epidermal Growth Factor-Like Protein 1 3 4
  • Multiple EGF-Like Domains Protein 2 3 4
  • Cadherin Family Member 11 3 4
  • Flamingo Homolog 1 3 4
  • EGF-Like Protein 1 3 4
  • CDHF11 3 4
  • HFMI1 3 4
  • EGFL1 3 4
  • MEGF2 3 4
  • FMI1 3 4
  • Cadherin, EGF LAG Seven-Pass G-Type Receptor 3 (Flamingo Homolog, Drosophila) 3
  • Cadherin EGF LAG Seven-Pass G-Type Receptor 3, Flamingo (Drosophila) Homolog 2
  • Flamingo Homolog 1 (Drosophila) 2
  • EGF-Like-Domain, Multiple 1 3
  • Anchor Protein 3
  • KIAA0812 4
  • ADGRC3 3
  • RESDA1 3

External Ids for CELSR3 Gene

Previous HGNC Symbols for CELSR3 Gene

  • EGFL1

Previous GeneCards Identifiers for CELSR3 Gene

  • GC03M048463
  • GC03M047956
  • GC03M048493
  • GC03M048634
  • GC03M048638
  • GC03M048648

Summaries for CELSR3 Gene

Entrez Gene Summary for CELSR3 Gene

  • This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]

GeneCards Summary for CELSR3 Gene

CELSR3 (Cadherin EGF LAG Seven-Pass G-Type Receptor 3) is a Protein Coding gene. Among its related pathways are GPCRs, Other. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. An important paralog of this gene is FAT4.

UniProtKB/Swiss-Prot for CELSR3 Gene

  • Receptor that may have an important role in cell/cell signaling during nervous system formation.

Gene Wiki entry for CELSR3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELSR3 Gene

Genomics for CELSR3 Gene

Regulatory Elements for CELSR3 Gene

Enhancers for CELSR3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CELSR3 on UCSC Golden Path with GeneCards custom track

Promoters for CELSR3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CELSR3 on UCSC Golden Path with GeneCards custom track

Genomic Location for CELSR3 Gene

Chromosome:
3
Start:
48,636,463 bp from pter
End:
48,662,915 bp from pter
Size:
26,453 bases
Orientation:
Minus strand

Genomic View for CELSR3 Gene

Genes around CELSR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CELSR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CELSR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELSR3 Gene

Proteins for CELSR3 Gene

  • Protein details for CELSR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYQ7-CELR3_HUMAN
    Recommended name:
    Cadherin EGF LAG seven-pass G-type receptor 3
    Protein Accession:
    Q9NYQ7
    Secondary Accessions:
    • O75092

    Protein attributes for CELSR3 Gene

    Size:
    3312 amino acids
    Molecular mass:
    358185 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CELSR3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CELSR3 Gene

Proteomics data for CELSR3 Gene at MOPED

Post-translational modifications for CELSR3 Gene

  • Ubiquitination at Lys 2143, Lys 2477, and Lys 2790
  • Glycosylation at Asn 632, Asn 847, Asn 1182, Asn 1222, Asn 1317, Asn 1327, Asn 1649, Asn 1713, Asn 1770, Asn 2053, Asn 2177, Asn 2196, Asn 2386, Asn 2474, and Asn 2506
  • Modification sites at PhosphoSitePlus

Other Protein References for CELSR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for CELSR3

No data available for DME Specific Peptides for CELSR3 Gene

Domains & Families for CELSR3 Gene

Suggested Antigen Peptide Sequences for CELSR3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYQ7

UniProtKB/Swiss-Prot:

CELR3_HUMAN :
  • Contains 9 cadherin domains.
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
Domain:
  • Contains 9 cadherin domains.
  • Contains 8 EGF-like domains.
  • Contains 1 GPS domain.
  • Contains 1 laminin EGF-like domain.
  • Contains 2 laminin G-like domains.
Family:
  • Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.
genes like me logo Genes that share domains with CELSR3: view

Function for CELSR3 Gene

Molecular function for CELSR3 Gene

UniProtKB/Swiss-Prot Function:
Receptor that may have an important role in cell/cell signaling during nervous system formation.

Gene Ontology (GO) - Molecular Function for CELSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IEA,IPI 17474147
genes like me logo Genes that share ontologies with CELSR3: view
genes like me logo Genes that share phenotypes with CELSR3: view

Animal Models for CELSR3 Gene

MGI Knock Outs for CELSR3:

Animal Model Products

  • Taconic Biosciences Mouse Models for CELSR3

miRNA for CELSR3 Gene

miRTarBase miRNAs that target CELSR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CELSR3 Gene

Localization for CELSR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELSR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CELSR3 Gene COMPARTMENTS Subcellular localization image for CELSR3 gene
Compartment Confidence
plasma membrane 5

No data available for Gene Ontology (GO) - Cellular Components for CELSR3 Gene

Pathways & Interactions for CELSR3 Gene

SuperPathways for CELSR3 Gene

Superpath Contained pathways
1 GPCRs, Other
genes like me logo Genes that share pathways with CELSR3: view

Pathways by source for CELSR3 Gene

1 BioSystems pathway for CELSR3 Gene

Gene Ontology (GO) - Biological Process for CELSR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001764 neuron migration IEA --
GO:0001932 regulation of protein phosphorylation IEA --
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
GO:0007166 cell surface receptor signaling pathway IEA --
GO:0007413 axonal fasciculation IEA --
genes like me logo Genes that share ontologies with CELSR3: view

No data available for SIGNOR curated interactions for CELSR3 Gene

Drugs & Compounds for CELSR3 Gene

No Compound Related Data Available

Transcripts for CELSR3 Gene

Unigene Clusters for CELSR3 Gene

Cadherin, EGF LAG seven-pass G-type receptor 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CELSR3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36a · 36b · 36c ^ 37a · 37b ^ 38 ^ 39a · 39b ^ 40a · 40b · 40c ^ 41a · 41b ·
SP1: - -
SP2: - - -
SP3: - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - - - -
SP8:
SP9:
SP10: - -
SP11:
SP12:
SP13: - - - - -
SP14:
SP15: - - -
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

ExUns: 41c · 41d ^ 42a · 42b ^ 43a · 43b · 43c ^ 44a · 44b · 44c · 44d ^ 45a · 45b ^ 46a · 46b ^ 47a · 47b · 47c ^ 48 ^ 49 ^ 50 ^ 51 ^ 52 ^ 53a · 53b · 53c ^
SP1:
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: - - - - - - - -
SP8: - - - -
SP9: - - -
SP10: - -
SP11: - - -
SP12: -
SP13: - -
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21: -
SP22:

ExUns: 54a · 54b · 54c ^ 55a · 55b · 55c · 55d ^ 56 ^ 57 ^ 58a ·
SP1:
SP2: - - - -
SP3: - - - -
SP4: - - - -
SP5: - - - -
SP6: - - - -
SP7: - - - -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: -
SP18:
SP19:
SP20:
SP21:
SP22: - - -

Relevant External Links for CELSR3 Gene

GeneLoc Exon Structure for
CELSR3
ECgene alternative splicing isoforms for
CELSR3

Expression for CELSR3 Gene

mRNA expression in normal human tissues for CELSR3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELSR3 Gene

This gene is overexpressed in Brain - Cerebellum (x9.1), Brain - Cerebellar Hemisphere (x7.9), and Pituitary (x6.7).

Protein differential expression in normal tissues from HIPED for CELSR3 Gene

This gene is overexpressed in Bone (31.2) and Pancreas (20.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CELSR3 Gene



SOURCE GeneReport for Unigene cluster for CELSR3 Gene Hs.631926

genes like me logo Genes that share expression patterns with CELSR3: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CELSR3 Gene

Orthologs for CELSR3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CELSR3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CELSR3 35
  • 88.8 (n)
  • 93.17 (a)
CELSR3 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CELSR3 35
  • 89.02 (n)
  • 92.48 (a)
CELSR3 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Celsr3 35
  • 87.03 (n)
  • 92.6 (a)
Celsr3 16
Celsr3 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CELSR3 35
  • 98.97 (n)
  • 98.54 (a)
CELSR3 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Celsr3 35
  • 86.44 (n)
  • 91.8 (a)
oppossum
(Monodelphis domestica)
Mammalia CELSR3 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CELSR3 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves CELSR3 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CELSR3 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia celsr3 35
  • 65.98 (n)
  • 68.98 (a)
zebrafish
(Danio rerio)
Actinopterygii celsr3 35
  • 65.28 (n)
  • 67.4 (a)
celsr3 36
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Cad89D 37
  • 25 (a)
CadN2 37
  • 25 (a)
shg 37
  • 25 (a)
stan 37
  • 42 (a)
stan 36
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea fmi-1 36
  • 27 (a)
OneToMany
Species with no ortholog for CELSR3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CELSR3 Gene

ENSEMBL:
Gene Tree for CELSR3 (if available)
TreeFam:
Gene Tree for CELSR3 (if available)

Paralogs for CELSR3 Gene

Paralogs for CELSR3 Gene

(15) SIMAP similar genes for CELSR3 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CELSR3: view

Variants for CELSR3 Gene

Sequence variations from dbSNP and Humsavar for CELSR3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_020022 -
rs3821875 - 48,660,221(-) CATCA(C/G)CACCC reference, missense
rs12107252 - 48,653,883(+) TAAGC(C/T)GACAG reference, missense
rs2286651 -- 48,656,714(-) GTCTG(C/T)CGCCC reference, synonymous-codon
rs2286652 -- 48,651,759(-) CCATG(C/T)TCTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CELSR3 Gene

Variant ID Type Subtype PubMed ID
nsv523981 CNV Loss 19592680
nsv834685 CNV Loss 17160897
nsv876762 CNV Loss 21882294
nsv818138 CNV Gain 17921354
nsv876763 CNV Loss 21882294
nsv822075 CNV Gain 20364138

Variation tolerance for CELSR3 Gene

Residual Variation Intolerance Score: 4.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.47; 91.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CELSR3 Gene

HapMap Linkage Disequilibrium report
CELSR3
Human Gene Mutation Database (HGMD)
CELSR3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELSR3 Gene

Disorders for CELSR3 Gene

Relevant External Links for CELSR3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CELSR3

No disorders were found for CELSR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CELSR3 Gene

Publications for CELSR3 Gene

  1. Identification of high-molecular-weight proteins with multiple EGF- like motifs by motif-trap screening. (PMID: 9693030) Nakayama M. … Ohara O. (Genomics 1998) 2 3 4 67
  2. Celsr3 and Fzd3 in axon guidance. (PMID: 25813877) Chai G. … Tissir F. (Int. J. Biochem. Cell Biol. 2015) 3
  3. SR protein kinases promote splicing of nonconsensus introns. (PMID: 26167880) Lipp J.J. … Guthrie C. (Nat. Struct. Mol. Biol. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy. (PMID: 26460568) Johnson-Kerner B.L. … Wichterle H. (PLoS ONE 2015) 3

Products for CELSR3 Gene

Sources for CELSR3 Gene

Content