Aliases for CELSR1 Gene
External Ids for CELSR1 Gene
Previous GeneCards Identifiers for CELSR1 Gene
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
GeneCards Summary for CELSR1 Gene
CELSR1 (Cadherin, EGF LAG Seven-Pass G-Type Receptor 1) is a Protein Coding gene. Diseases associated with CELSR1 include neural tube defects and craniorachischisis. Among its related pathways are Glucose / Energy Metabolism and GPCRs, Other. GO annotations related to this gene include calcium ion binding and protein dimerization activity. An important paralog of this gene is FAT4.
UniProtKB/Swiss-Prot for CELSR1 Gene
Receptor that may have an important role in cell/cell signaling during nervous system formation