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CELP Gene

pseudogene   GIFtS: 31
GCID: GC09P135987

Carboxyl Ester Lipase Pseudogene

(Previous name: carboxyl ester lipase-like (bile salt-stimulated lipase-like))
(Previous symbol: CELL)
  Search for CELP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxyl Ester Lipase Pseudogene1 2     cell22
CELL1 2 4     cell32
Carboxyl Ester Lipase-Like (Bile Salt-Stimulated Lipase-Like)1     CEL4
cell12     Carboxyl Ester Lipase-Like Protein4

External Ids:    HGNC: 18491   Entrez Gene: 10572   Ensembl: ENSG000001708277   UniProtKB: Q140184   

Export aliases for CELP gene to outside databases

Previous GC identifers: GC09P127514 GC09P129311 GC09P131233 GC09P132987 GC09P134947 GC09P135958 GC09P105451 GC09P135959


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CELP Gene:
CELP (carboxyl ester lipase pseudogene) is a pseudogene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000009.11  NC_018920.2  NT_008470.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CELP gene promoter:
         AP-2alpha isoform 3   AP-1   AP-2alpha isoform 4   AP-2alpha isoform 2   AP-2alpha   AP-2alphaA   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELP promoter sequence
   Search Chromatin IP Primers for CELP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CELP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q34.3   Ensembl cytogenetic band:  9q34.2   HGNC cytogenetic band: 9q34.2

CELP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELP gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P135987:  view genomic region     (about GC identifiers)

Start:
135,957,926 bp from pter      End:
135,962,742 bp from pter
Size:
4,817 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: Q14018 (See protein sequence)
Recommended Name: Carboxyl ester lipase (Bile salt-stimulated lipase), isoform CRA_a  
Size: 59 amino acids; 6208 Da


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q14018


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CELP
Interactions:

    GeneGlobe Interaction Network for CELP

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Compounds for CELP available from Tocris Bioscience    About this table
CompoundAction CAS #
JZL 184Monoacylglycerol lipase (MAGL) inhibitor[1101854-58-3]
Orlistat Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity [96829-58-2]
Pristimerin Potent, reversible MAGL inhibitor [1258-84-0]
GSK 264220AEndothelial lipase and lipoprotein lipase inhibitor[685506-42-7]



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for CELP:

Carboxyl ester lipase pseudogene
Hs.654361  [show with all ESTs]
Unigene Representative Sequence: L14813
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000421286 ENST00000411440(uc011mcu.1)
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Additional mRNA sequence: 

L14813.1 NR_001275.2 

4 DOTS entries:

DT.40119873  DT.75163462  DT.121143229  DT.121143238 

Selected AceView cDNA sequences (see all 32):

BM055183 AK098728 CD612866 CD612868 AW371544 AF081673 CD612870 CD612864 
L14813 CK904837 NM_001807 CD612859 CD612861 M85201 BC042510 S70516 
BF883469 S79774 BM352607 X54457 NR_001275 CD612857 S70517 BF913619 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CELP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CCCTCCACAG
CELP Expression
About this image

CELP Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.654361
    Custom PCR Arrays for CELP
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for CELP (if available)
TreeFam Gene Tree for CELP (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CELP gene
1 SIMAP similar gene for CELP using alignment to 1 protein entry:     Q14018_HUMAN:
CEL

Find genes that share paralogs with CELP           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CELP (see all 218)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 9 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1384722061,2
--135955992(+) CAGAGC/TATGGC 1 -- us2k10--------
rs1428103611,2
--135956012(+) GTTAGA/GGGCTG 1 -- us2k10--------
rs1880784671,2
--135956067(+) AGGCGA/GGCAGA 1 -- us2k10--------
rs1921299941,2
--135956068(+) GGCGGA/GCAGAT 1 -- us2k10--------
rs1842177251,2
--135956069(+) GCGGGC/GAGATC 1 -- us2k10--------
rs1995408861,2
C--135956301(+) CAAAC-/AAAAAA 1 -- us2k10--------
rs1878364471,2
C--135956379(+) GTACCA/CCCTGG 1 -- us2k10--------
rs1926147411,2
--135956384(+) CCCTGG/TTGGGG 1 -- us2k10--------
rs1460523911,2
C--135956493(+) ATGTAC/TATATA 1 -- us2k10--------
rs1846386211,2
--135956528(+) TCTCCA/CCTGCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CELP (135957926 - 135962742 bp)

Structural Variations
     Database of Genomic Variants (DGV) 7 variations for CELP:    About this table    
Variant IDTypeSubtypePubMed ID
esv2739138CNV Deletion23290073
nsv6747CNV Insertion18451855
dgv8320n71CNV Loss21882294
nsv894030CNV Loss21882294
nsv894031CNV Gain21882294
dgv1242n67CNV Gain20364138
nsv831744CNV Gain+Loss17160897

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing CELP
DNA2.0 Custom Variant and Variant Library Synthesis for CELP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CELP gene integrated from 10 sources:
(articles sorted by number of sources associating them with CELP)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genomic organization, sequence analysis, and chromosomal localization of the human carboxyl ester lipase (CEL) gene and a CEL-like (CELL) gene. (PubMed id 1639390)1, 3, 9 Lidberg U.... Bjursell G. (Genomics 1992)
  2. The human carboxyl ester lipase-like (CELL) gene is ubiquitously expressed and contains a hypervariable region. (PubMed id 7691717)1, 9 Nilsson J.... Bjursell G. (Genomics 1993)
  3. Structure of the human pancreatic cholesterol esterase gene. (PubMed id 1627550)1 Kumar B.V.... Lange L.G. (Biochemistry 1992)
  4. Processed pseudogenes: characteristics and evolution. (PubMed id 3909943)1 Vanin E.F. (Annu. Rev. Genet. 1985)
  5. Characterization of the gorilla carboxyl ester lipase locus, and the appearance of the carboxyl ester lipase pseudogene during primate evolution. (PubMed id 10548728)9 Madeyski K....Nilsson J. (Gene 1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1057 HGNC: 1849 AceView: CELandCELP Ensembl:ENSG00000170827 euGenes: HUgn1057
ECgene: CELP H-InvDB: CELP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CELP Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CELP Genetics and Cytogenetics in Oncology and Haematology

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CELP gene:
Search GeneIP for patents involving CELP

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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