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Aliases for CELF6 Gene

Aliases for CELF6 Gene

  • CUGBP, Elav-Like Family Member 6 2 3
  • BRUNOL6 3 4 6
  • CUG-BP- And ETR-3-Like Factor 6 3 4
  • RNA-Binding Protein BRUNOL-6 3 4
  • Bruno-Like Protein 6 3 4
  • CELF-6 3 4
  • Bruno (Drosophila) -Like 6, RNA Binding Protein 2
  • Bruno-Like 6, RNA Binding Protein (Drosophila) 2
  • Bruno -Like 6, RNA Binding Protein 3
  • Bruno-Like 6, RNA Binding Protein 3
  • CUGBP Elav-Like Family Member 6 3
  • CUG-BP And ETR-3 Like Factor 6 3

External Ids for CELF6 Gene

Previous Symbols for CELF6 Gene

  • BRUNOL6

Summaries for CELF6 Gene

Entrez Gene Summary for CELF6 Gene

  • Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for CELF6 Gene

CELF6 (CUGBP, Elav-Like Family Member 6) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CELF5.

UniProtKB/Swiss-Prot for CELF6 Gene

  • RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELF6 Gene

Genomics for CELF6 Gene

Genomic Location for CELF6 Gene

Start:
72,284,727 bp from pter
End:
72,320,184 bp from pter
Size:
35,458 bases
Orientation:
Minus strand

Genomic View for CELF6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELF6 Gene

No data available for Regulatory Elements for CELF6 Gene

Proteins for CELF6 Gene

  • Protein details for CELF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96J87-CELF6_HUMAN
    Recommended name:
    CUGBP Elav-like family member 6
    Protein Accession:
    Q96J87
    Secondary Accessions:
    • B4DG28
    • B4DJB6
    • Q6PII4
    • Q6ZNJ7
    • Q8N607

    Protein attributes for CELF6 Gene

    Size:
    481 amino acids
    Molecular mass:
    50477 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC85148.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CELF6 Gene

    Alternative splice isoforms for CELF6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CELF6 Gene

Proteomics data for CELF6 Gene at MOPED

Post-translational modifications for CELF6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CELF6 Gene

No data available for DME Specific Peptides for CELF6 Gene

Domains for CELF6 Gene

Gene Families for CELF6 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for CELF6 Gene

UniProtKB/Swiss-Prot:

CELF6_HUMAN
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.:
    • Q96J87
Family:
  • Belongs to the CELF/BRUNOL family.:
    • Q96J87
genes like me logo Genes that share domains with CELF6: view

Function for CELF6 Gene

Molecular function for CELF6 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of TNNT2 in a muscle-specific splicing enhancer (MSE)-dependent manner. Promotes also exon exclusion of INSR pre-mRNA.

Gene Ontology (GO) - Molecular Function for CELF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding NAS 14761971
genes like me logo Genes that share ontologies with CELF6: view
genes like me logo Genes that share phenotypes with CELF6: view

Animal Models for CELF6 Gene

MGI Knock Outs for CELF6:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CELF6 Gene

Localization for CELF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELF6 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CELF6 Gene COMPARTMENTS Subcellular localization image for CELF6 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CELF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 14761971
GO:0005737 cytoplasm NAS 14761971
genes like me logo Genes that share ontologies with CELF6: view

Pathways for CELF6 Gene

SuperPathways for CELF6 Gene

No Data Available

Interacting Proteins for CELF6 Gene

Gene Ontology (GO) - Biological Process for CELF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 14761971
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with CELF6: view

No data available for Pathways by source for CELF6 Gene

Transcripts for CELF6 Gene

Unigene Clusters for CELF6 Gene

CUGBP, Elav-like family member 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CELF6 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16
SP1: -
SP2:
SP3: - - -
SP4: - - - -

Relevant External Links for CELF6 Gene

GeneLoc Exon Structure for
CELF6
ECgene alternative splicing isoforms for
CELF6

Expression for CELF6 Gene

mRNA expression in normal human tissues for CELF6 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CELF6 Gene

SOURCE GeneReport for Unigene cluster for CELF6 Gene Hs.348342

mRNA Expression by UniProt/SwissProt for CELF6 Gene

Q96J87-CELF6_HUMAN
Tissue specificity: Expressed mainly in kidney, brain and testis and present in other tissues albeit at lower levels. Also expressed in fetal kidney.
genes like me logo Genes that share expressions with CELF6: view

Orthologs for CELF6 Gene

This gene was present in the common ancestor of animals.

Orthologs for CELF6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 98 (a)
OneToMany
cow
(Bos Taurus)
Mammalia -- 37
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Celf6 16
Celf6 37
  • 96 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 74 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 77 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii CELF6 37
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bru-3 37
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-75 37
  • 47 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8737 37
  • 41 (a)
OneToMany
Species with no ortholog for CELF6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CELF6 Gene

ENSEMBL:
Gene Tree for CELF6 (if available)
TreeFam:
Gene Tree for CELF6 (if available)

Paralogs for CELF6 Gene

Paralogs for CELF6 Gene

Selected SIMAP similar genes for CELF6 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CELF6: view

Variants for CELF6 Gene

Sequence variations from dbSNP and Humsavar for CELF6 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs959717 -- 72,312,308(+) AGCAA(A/G)AGAAG intron-variant
rs1895873 -- 72,293,323(+) CCTAA(C/G)AGTAG intron-variant
rs2008800 -- 72,303,944(+) CCTCC(A/G)CCTCC intron-variant
rs2008817 -- 72,304,162(+) CACCG(C/T)GCTCA intron-variant
rs2009365 -- 72,318,508(+) GTGTT(C/T)CTTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CELF6 Gene

Variant ID Type Subtype PubMed ID
nsv1601 CNV Loss 18451855

Relevant External Links for CELF6 Gene

HapMap Linkage Disequilibrium report
CELF6
Human Gene Mutation Database (HGMD)
CELF6

Disorders for CELF6 Gene

(1) University of Copenhagen DISEASES for CELF6 Gene

Relevant External Links for CELF6

Genetic Association Database (GAD)
CELF6
genes like me logo Genes that share disorders with CELF6: view

No data available for UniProtKB/Swiss-Prot for CELF6 Gene

Publications for CELF6 Gene

  1. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. (PMID: 10893231) Good P.J. … Herring D.C. (J. Biol. Chem. 2000) 2 3 4
  2. CELF6, a member of the CELF family of RNA-binding proteins, regulates muscle-specific splicing enhancer-dependent alternative splicing. (PMID: 14761971) Ladd A.N. … Cooper T.A. (J. Biol. Chem. 2004) 3 4 23
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Expressed sequence tag analysis of human RPE/choroid for the NEIBank project: over 6000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107410) Wistow G. … Peterson K. (Mol. Vis. 2002) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CELF6 Gene

Sources for CELF6 Gene

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