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Aliases for CELF5 Gene

Aliases for CELF5 Gene

  • CUGBP, Elav-Like Family Member 5 2 3
  • BRUNOL5 3 4 6
  • RNA-Binding Protein BRUNOL-5 3 4
  • CELF-5 3 4
  • Bruno (Drosophila) -Like 5, RNA Binding Protein 2
  • Bruno-Like 5, RNA Binding Protein (Drosophila) 2
  • Bruno-Like 5 RNA Binding Protein 3
  • CUGBP Elav-Like Family Member 5 3
  • CUG-BP- And ETR-3-Like Factor 5 4
  • CUG-BP And ETR-3 Like Factor 5 3
  • Bruno-Like Protein 5 4
  • BRUNOL-5 3

External Ids for CELF5 Gene

Previous HGNC Symbols for CELF5 Gene

  • BRUNOL5

Previous GeneCards Identifiers for CELF5 Gene

  • GC19P002992

Summaries for CELF5 Gene

Entrez Gene Summary for CELF5 Gene

  • This gene encodes a member of the the CELF/BRUNOL protein family, which contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing and translation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for CELF5 Gene

CELF5 (CUGBP, Elav-Like Family Member 5) is a Protein Coding gene. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CELF4.

UniProtKB/Swiss-Prot for CELF5 Gene

  • RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELF5 Gene

Genomics for CELF5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CELF5 Gene

Start:
3,224,676 bp from pter
End:
3,297,076 bp from pter
Size:
72,401 bases
Orientation:
Plus strand

Genomic View for CELF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELF5 Gene

No data available for Regulatory Elements for CELF5 Gene

Proteins for CELF5 Gene

  • Protein details for CELF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6W0-CELF5_HUMAN
    Recommended name:
    CUGBP Elav-like family member 5
    Protein Accession:
    Q8N6W0
    Secondary Accessions:
    • D6W614
    • O75253
    • Q59GP2
    • Q86VW6
    • Q9BZC0
    • Q9NR86

    Protein attributes for CELF5 Gene

    Size:
    485 amino acids
    Molecular mass:
    52355 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC27666.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07476.1; Type=Erroneous termination; Positions=482; Note=Translated as Gly.; Evidence={ECO:0000305}; Sequence=BAD92304.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CELF5 Gene

    Alternative splice isoforms for CELF5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CELF5 Gene

Proteomics data for CELF5 Gene at MOPED

Post-translational modifications for CELF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CELF5 Gene

No data available for DME Specific Peptides for CELF5 Gene

Domains for CELF5 Gene

Gene Families for CELF5 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for CELF5 Gene

Suggested Antigen Peptide Sequences for CELF5 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6W0

UniProtKB/Swiss-Prot:

CELF5_HUMAN :
  • Q8N6W0
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the CELF/BRUNOL family.
genes like me logo Genes that share domains with CELF5: view

Function for CELF5 Gene

Molecular function for CELF5 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein implicated in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Gene Ontology (GO) - Molecular Function for CELF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with CELF5: view

Phenotypes for CELF5 Gene

GenomeRNAi human phenotypes for CELF5:
genes like me logo Genes that share phenotypes with CELF5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELF5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CELF5 Gene

Localization for CELF5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELF5 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CELF5 Gene COMPARTMENTS Subcellular localization image for CELF5 gene
Compartment Confidence
nucleus 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CELF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CELF5: view

Pathways for CELF5 Gene

SuperPathways for CELF5 Gene

No Data Available

Interacting Proteins for CELF5 Gene

Gene Ontology (GO) - Biological Process for CELF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006397 mRNA processing IEA --
genes like me logo Genes that share ontologies with CELF5: view

No data available for Pathways by source for CELF5 Gene

Transcripts for CELF5 Gene

Unigene Clusters for CELF5 Gene

CUGBP, Elav-like family member 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELF5

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CELF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CELF5 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14 ^ 15
SP1: - - - - -
SP2: - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6: - - -
SP7:

Relevant External Links for CELF5 Gene

GeneLoc Exon Structure for
CELF5
ECgene alternative splicing isoforms for
CELF5

Expression for CELF5 Gene

mRNA expression in normal human tissues for CELF5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELF5 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (5.7), Brain - Cortex (5.6), Brain - Anterior cingulate cortex (BA24) (5.2), Brain - Frontal Cortex (BA9) (4.7), Brain - Amygdala (4.3), Brain - Putamen (basal ganglia) (4.3), and Brain - Caudate (basal ganglia) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CELF5 Gene

SOURCE GeneReport for Unigene cluster for CELF5 Gene Hs.655747

mRNA Expression by UniProt/SwissProt for CELF5 Gene

Q8N6W0-CELF5_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expressions with CELF5: view

In Situ Assay Products

Orthologs for CELF5 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CELF5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CELF5 35
  • 95.32 (n)
  • 95.04 (a)
CELF5 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CELF5 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CELF5 35
  • 94.71 (n)
  • 99.59 (a)
CELF5 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Celf5 35
  • 88.95 (n)
  • 96.22 (a)
Celf5 16
Celf5 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CELF5 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CELF5 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Celf5 35
  • 88.37 (n)
  • 94.77 (a)
chicken
(Gallus gallus)
Aves BRUNOL5 35
  • 81.22 (n)
  • 92.45 (a)
CELF5 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CELF5 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia celf5 35
  • 75.38 (n)
  • 84.44 (a)
zebrafish
(Danio rerio)
Actinopterygii CELF5 (2 of 3) 36
  • 58 (a)
OneToMany
celf5a 35
  • 73.47 (n)
  • 77.13 (a)
celf5a 36
  • 60 (a)
OneToMany
celf5b 36
  • 72 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004950 35
  • 61.76 (n)
  • 64.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta bru-3 35
  • 63.54 (n)
  • 62.46 (a)
bru-3 36
  • 54 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-75 35
  • 57.85 (n)
  • 58.16 (a)
unc-75 36
  • 48 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G03457 35
  • 52.72 (n)
  • 49.32 (a)
rice
(Oryza sativa)
Liliopsida Os05g0373400 35
  • 48.12 (n)
  • 41.67 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8737 36
  • 43 (a)
OneToMany
Species with no ortholog for CELF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CELF5 Gene

ENSEMBL:
Gene Tree for CELF5 (if available)
TreeFam:
Gene Tree for CELF5 (if available)

Paralogs for CELF5 Gene

Paralogs for CELF5 Gene

Selected SIMAP similar genes for CELF5 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CELF5: view

Variants for CELF5 Gene

Sequence variations from dbSNP and Humsavar for CELF5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs13965 -- 3,293,371(-) CCGTT(A/C)ATGGC utr-variant-3-prime, reference, missense, nc-transcript-variant
rs167487 -- 3,231,706(+) tgggc(A/G)gatga intron-variant
rs167519 -- 3,289,720(+) attag(C/T)aacgc intron-variant
rs312054 -- 3,239,744(+) CCCCA(C/T)GGCCC intron-variant
rs312055 -- 3,235,826(+) gatgg(A/G)tggat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CELF5 Gene

Variant ID Type Subtype PubMed ID
nsv509716 CNV Insertion 20534489
dgv3648n71 CNV Loss 21882294
dgv3649n71 CNV Loss 21882294
nsv833712 CNV Loss 17160897
esv2494686 CNV Insertion 19546169
esv1459053 CNV Insertion 17803354
esv1699504 CNV Insertion 17803354
nsv910722 CNV Loss 21882294
nsv910723 CNV Loss 21882294
nsv509717 CNV Insertion 20534489

Relevant External Links for CELF5 Gene

HapMap Linkage Disequilibrium report
CELF5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELF5 Gene

Disorders for CELF5 Gene

Relevant External Links for CELF5

Genetic Association Database (GAD)
CELF5
genes like me logo Genes that share disorders with CELF5: view

No data available for UniProtKB/Swiss-Prot for CELF5 Gene

Publications for CELF5 Gene

  1. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. (PMID: 10893231) Good P.J. … Herring D.C. (J. Biol. Chem. 2000) 2 3 4
  2. The CELF family of RNA binding proteins is implicated in cell- specific and developmentally regulated alternative splicing. (PMID: 11158314) Ladd A.N. … Cooper T.A. (Mol. Cell. Biol. 2001) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Differential expression of the Brunol/CELF family genes during Xenopus laevis early development. (PMID: 19757395) Wu J. … Mao B. (Int. J. Dev. Biol. 2010) 3
  5. A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder. (PMID: 20889312) Wang K.S. … Aragam N. (Schizophr. Res. 2010) 3

Products for CELF5 Gene

Sources for CELF5 Gene

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