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Aliases for CELF3 Gene

Aliases for CELF3 Gene

  • CUGBP, Elav-Like Family Member 3 2 3
  • BRUNOL1 3 4 6
  • TNRC4 3 4 6
  • Trinucleotide Repeat-Containing Gene 4 Protein 3 4
  • Expanded Repeat Domain Protein CAG/CTG 4 3 4
  • Trinucleotide Repeat Containing 4 2 3
  • CUG-BP- And ETR-3-Like Factor 3 3 4
  • ELAV-Type RNA-Binding Protein 1 3 4
  • CUG-BP And ETR-3 Like Factor 3 2 3
  • RNA-Binding Protein BRUNOL-1 3 4
  • Bruno-Like Protein 1 3 4
  • CAG Repeat Protein 4 3 4
  • CAG Repeat Domain 2 3
  • CAGH4 3 4
  • ERDA4 3 4
  • ETR-1 3 4
  • Expanded Repeat Domain, CAG/CTG 4 3
  • CUGBP Elav-Like Family Member 3 3
  • Expanded Repeat Domain 2
  • CAG/CTG 4 2
  • CELF-3 4

External Ids for CELF3 Gene

Previous HGNC Symbols for CELF3 Gene

  • TNRC4

Previous GeneCards Identifiers for CELF3 Gene

  • GC01M123049

Summaries for CELF3 Gene

Entrez Gene Summary for CELF3 Gene

  • Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2010]

GeneCards Summary for CELF3 Gene

CELF3 (CUGBP, Elav-Like Family Member 3) is a Protein Coding gene. GO annotations related to this gene include RNA binding and mRNA binding. An important paralog of this gene is CELF5.

UniProtKB/Swiss-Prot for CELF3 Gene

  • RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELF3 Gene

Genomics for CELF3 Gene

Genomic Location for CELF3 Gene

Start:
151,700,052 bp from pter
End:
151,716,814 bp from pter
Size:
16,763 bases
Orientation:
Minus strand

Genomic View for CELF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELF3 Gene

No data available for Regulatory Elements for CELF3 Gene

Proteins for CELF3 Gene

  • Protein details for CELF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SZQ8-CELF3_HUMAN
    Recommended name:
    CUGBP Elav-like family member 3
    Protein Accession:
    Q5SZQ8
    Secondary Accessions:
    • B7ZKK6
    • O15414
    • Q499Y6
    • Q5SZQ7
    • Q6NVK0
    • Q8IZ98
    • Q9BZC2
    • Q9HB30

    Protein attributes for CELF3 Gene

    Size:
    465 amino acids
    Molecular mass:
    50548 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAB91444.1; Type=Frameshift; Positions=136; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CELF3 Gene

    Alternative splice isoforms for CELF3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CELF3 Gene

Proteomics data for CELF3 Gene at MOPED

Post-translational modifications for CELF3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CELF3 Gene

No data available for DME Specific Peptides for CELF3 Gene

Domains for CELF3 Gene

Gene Families for CELF3 Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing
  • TNRC :Trinucleotide (CAG) repeat containing

Protein Domains for CELF3 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5SZQ8

UniProtKB/Swiss-Prot:

CELF3_HUMAN :
  • Q5SZQ8
Domain:
  • Contains 3 RRM (RNA recognition motif) domains.
Family:
  • Belongs to the CELF/BRUNOL family.
genes like me logo Genes that share domains with CELF3: view

Function for CELF3 Gene

Molecular function for CELF3 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking the alternative exon 5 of TNNT2 pre-mRNA.

Gene Ontology (GO) - Molecular Function for CELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IMP 17725984
GO:0003729 mRNA binding NAS 11158314
genes like me logo Genes that share ontologies with CELF3: view

Phenotypes for CELF3 Gene

MGI mutant phenotypes for CELF3:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CELF3: view

Animal Models for CELF3 Gene

MGI Knock Outs for CELF3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELF3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CELF3 Gene

Localization for CELF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELF3 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CELF3 Gene COMPARTMENTS Subcellular localization image for CELF3 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 11158314
GO:0005737 cytoplasm IDA 17725984
genes like me logo Genes that share ontologies with CELF3: view

Pathways for CELF3 Gene

SuperPathways for CELF3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CELF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA 11158314
GO:0000398 mRNA splicing, via spliceosome NAS 11158314
GO:0007283 spermatogenesis IEA --
GO:0008380 RNA splicing IMP 17725984
GO:0030317 sperm motility IEA --
genes like me logo Genes that share ontologies with CELF3: view

No data available for Pathways by source for CELF3 Gene

Transcripts for CELF3 Gene

Unigene Clusters for CELF3 Gene

CUGBP, Elav-like family member 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELF3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CELF3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2:
SP3: -
SP4:
SP5:

Relevant External Links for CELF3 Gene

GeneLoc Exon Structure for
CELF3
ECgene alternative splicing isoforms for
CELF3

Expression for CELF3 Gene

mRNA expression in normal human tissues for CELF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELF3 Gene

This gene is overexpressed in Pituitary (7.3), Brain - Cerebellum (5.2), Brain - Cerebellar Hemisphere (4.7), Brain - Cortex (4.3), Brain - Nucleus accumbens (basal ganglia) (4.3), and Brain - Anterior cingulate cortex (BA24) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CELF3 Gene

SOURCE GeneReport for Unigene cluster for CELF3 Gene Hs.26047

mRNA Expression by UniProt/SwissProt for CELF3 Gene

Q5SZQ8-CELF3_HUMAN
Tissue specificity: Expressed in brain.
genes like me logo Genes that share expressions with CELF3: view

In Situ Assay Products

Orthologs for CELF3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CELF3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CELF3 35
  • 98.87 (n)
  • 99.28 (a)
CELF3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CELF3 35
  • 95.23 (n)
  • 99.35 (a)
CELF3 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CELF3 35
  • 96.17 (n)
  • 99.35 (a)
CELF3 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Celf3 35
  • 94.25 (n)
  • 99.57 (a)
Celf3 16
Celf3 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CELF3 36
  • 67 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CELF3 36
  • 43 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Celf3 35
  • 93.76 (n)
  • 98.92 (a)
chicken
(Gallus gallus)
Aves CELF3 35
  • 83.07 (n)
  • 88.91 (a)
CELF3 36
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CELF3 36
  • 90 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia MGC68437 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15393 35
zebrafish
(Danio rerio)
Actinopterygii CELF3 (3 of 3) 36
  • 41 (a)
OneToMany
celf3a 35
  • 77.65 (n)
  • 82.85 (a)
celf3a 36
  • 82 (a)
OneToMany
celf3b 36
  • 77 (a)
OneToMany
etr1 35
fruit fly
(Drosophila melanogaster)
Insecta bru-3 36
  • 55 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-75 36
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3573 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8737 36
  • 41 (a)
OneToMany
Species with no ortholog for CELF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CELF3 Gene

ENSEMBL:
Gene Tree for CELF3 (if available)
TreeFam:
Gene Tree for CELF3 (if available)

Paralogs for CELF3 Gene

Paralogs for CELF3 Gene

Selected SIMAP similar genes for CELF3 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with CELF3: view

Variants for CELF3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CELF3 Gene

Q5SZQ8-CELF3_HUMAN
The poly-Gln tract in AAK07474 may be polymorphic

Sequence variations from dbSNP and Humsavar for CELF3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs3466 -- 151,700,182(+) AGGCT(C/T)ACAGA utr-variant-3-prime
rs868360 -- 151,718,672(-) GACCC(A/G)GGCAT upstream-variant-2KB
rs878775 -- 151,715,118(-) CTCTC(C/G)GTCCT intron-variant
rs939592 -- 151,714,507(+) GGAAA(A/T)TATGC intron-variant
rs1308144 -- 151,700,303(+) CATGA(A/G)GAAAG utr-variant-3-prime

Relevant External Links for CELF3 Gene

HapMap Linkage Disequilibrium report
CELF3

No data available for Structural Variations from Database of Genomic Variants (DGV) for CELF3 Gene

Disorders for CELF3 Gene

Relevant External Links for CELF3

Genetic Association Database (GAD)
CELF3
Human Genome Epidemiology (HuGE) Navigator
CELF3
genes like me logo Genes that share disorders with CELF3: view

No data available for UniProtKB/Swiss-Prot for CELF3 Gene

Publications for CELF3 Gene

  1. cDNAs with long CAG trinucleotide repeats from human brain. (PMID: 9225980) Margolis R.L. … Ross C.A. (Hum. Genet. 1997) 2 3 4
  2. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. (PMID: 10893231) Good P.J. … Herring D.C. (J. Biol. Chem. 2000) 3 4
  3. The CELF family of RNA binding proteins is implicated in cell- specific and developmentally regulated alternative splicing. (PMID: 11158314) Ladd A.N. … Cooper T.A. (Mol. Cell. Biol. 2001) 3 4
  4. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PMID: 15009664) Wang J. … Andreadis A. (J. Neurochem. 2004) 3 4
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48

Products for CELF3 Gene

Sources for CELF3 Gene

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