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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CELF3 Gene

protein-coding   GIFtS: 48
GCID: GC01M151674

CUGBP, Elav-like family member 3

(Previous name: trinucleotide repeat containing 4 )
(Previous symbol: TNRC4)
 Explore 7 diseases affiliated with
CELF3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CELF3    

Aliases
for CELF3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CUGBP, Elav-Like Family Member 31 2     ETR-12 3
BRUNOL11 2 3 5     CAG Repeat Protein 42 3
TNRC41 2 3 5     CUG-BP- And ETR-3-Like Factor 32 3
CAGH41 2 3     ELAV-Type RNA-Binding Protein 12 3
ERDA41 2 3     RNA-Binding Protein BRUNOL-12 3
Trinucleotide Repeat Containing 41 2     MGC572971
Bruno-Like Protein 12 3     CAG Repeat Domain2
Expanded Repeat Domain Protein CAG/CTG 42 3     CUG-BP And ETR-3 Like Factor 32
Trinucleotide Repeat-Containing Gene 4 Protein2 3     CUGBP Elav-Like Family Member 32
CELF-32 3     Expanded Repeat Domain, CAG/CTG 42

External Ids:    HGNC: 119671   Entrez Gene: 111892   Ensembl: ENSG000001594097   OMIM: 6126785   UniProtKB: Q5SZQ83   

Export aliases for CELF3 gene to outside databases

Previous GC identifer: GC01M123049


Summaries
for CELF3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CELF3:
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal
RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein
family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Multiple
alternatively spliced transcript variants encoding different isoforms have been identified in this gene. (provided by
RefSeq, Feb 2010)

UniProtKB/Swiss-Prot: CELF3_HUMAN, Q5SZQ8
Function: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion
and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.
Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult
transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic
sites flanking the alternative exon 5 of TNNT2 pre-mRNA




Genomic Views
for CELF3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CELF3
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CELF3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CELF3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELF3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CELF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELF3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M151674:  view genomic region     (about GC identifiers)

Start:
 151,672,534 bp from pter      End:
 151,689,290 bp from pter
Size:
 16,757 bases      Orientation:
 minus strand

Proteins
for CELF3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CELF3_HUMAN, Q5SZQ8 (See protein sequence)
Recommended Name: CUGBP Elav-like family member 3  
Size: 465 amino acids; 50548 Da
Subcellular location: Nucleus (By similarity). Cytoplasm (By similarity)
Sequence caution: Sequence=AAB91444.1; Type=Frameshift; Positions=136;
1 PDB 3D structure from and Proteopedia for CELF3:
2DNO (3D)    
Secondary accessions: B7ZKK6 O15414 Q499Y6 Q6NVK0 Q8IZ98 Q9BZC2 Q9HB30
Alternative splicing: 3 isoforms:  Q5SZQ8-1   Q5SZQ8-2   Q5SZQ8-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CELF3: NX_Q5SZQ8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5SZQ8

    • CELF3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001166119.1  NP_001166120.1  NP_009116.3  

    ENSEMBL proteins: 
     ENSP00000290585   ENSP00000290583   ENSP00000402503   ENSP00000376470  

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    Uscn Proteins for CELF3

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS11158314
    GO:0005737cytoplasm IDA17725984


    CELF3 for ontologies           About GeneDecksing



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    Uscn Antibodies for CELF3
    Search ThermoFisher Antibodies for CELF3

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    Uscn ELISAs and CLIAs for CELF3

    Protein Domains /
    Families
    for CELF3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CELF3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q5SZQ8

    ProtoNet protein and cluster: Q5SZQ8

    UniProtKB/Swiss-Prot: CELF3_HUMAN, Q5SZQ8
    Similarity: Belongs to the CELF/BRUNOL family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Function
    for CELF3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CELF3_HUMAN, Q5SZQ8
    Function: RNA-binding protein involved in the regulation of pre-mRNA alternative splicing. Mediates exon inclusion
    and/or exclusion in pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing.
    Specifically activates exon 5 inclusion of cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult
    transition. Activates the splicing of MAPT/Tau exon 10. Binds to muscle-specific splicing enhancer (MSE) intronic
    sites flanking the alternative exon 5 of TNNT2 pre-mRNA

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CELF3
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate CELF3 (see all 86):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-631 hsa-miR-146a hsa-miR-30d hsa-miR-4275 hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CELF3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CELF3 (see all 4)
    OriGene shRNA RFP: CELF3
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for CELF3

    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IMP17725984
    GO:0003729mRNA binding NAS11158314


    CELF3 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Celf3tm1Ade for CELF3
         1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Celf3):
     reproductive system 

    CELF3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CELF3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELF3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/11 Interacting proteins for CELF3 (Q5SZQ82, 3 ENSP000002905834) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP1Q153652, 3, ENSP000003055564MINT-2869493 I2D: score=2 STRING: ENSP00000305556
    RBFOX1Q9NWB12, 3, ENSP000003091174MINT-2869474 I2D: score=2 STRING: ENSP00000309117
    C14orf1Q9UKR52, 3MINT-65398 I2D: score=4 
    TLE1Q047242, 3MINT-65396 I2D: score=4 
    ANXA7P200732, 3MINT-8248823 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000381regulation of alternative mRNA splicing, via spliceosome IDA11158314
    GO:0000398mRNA splicing, via spliceosome NAS11158314
    GO:0007283spermatogenesis IEA--
    GO:0008380RNA splicing IMP17725984
    GO:0030317sperm motility IEA--


    CELF3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CELF3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CELF3
    Search CenterWatch for drugs/clinical trials and news about CELF3 

    Transcripts
    for CELF3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CELF3 gene (3 alternative transcripts): 
    NM_001172648.1  NM_001172649.1  NM_007185.4  

    Unigene Cluster for CELF3:

    CUGBP, Elav-like family member 3
    Hs.26047  [show with all ESTs]
    Unigene Representative Sequence: NM_007185
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000290585 ENST00000470688(uc010pdh.2) ENST00000290583(uc021oyt.1 uc009wmy.3 uc001eyr.3 uc001eyt.2 uc010pdi.1 uc001eys.2 uc009wmx.2)
    ENST00000420342 ENST00000419910 ENST00000479893 ENST00000478829 ENST00000392706


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CELF3
    8/86 QIAGEN miScript miRNA Assays for microRNAs that regulate CELF3 (see all 86):
    hsa-miR-548j hsa-miR-3607-3p hsa-miR-631 hsa-miR-146a hsa-miR-30d hsa-miR-4275 hsa-miR-877* hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmid: CELF3 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CELF3 (see all 4)
    OriGene shRNA RFP: CELF3
    OriGene siRNA: CELF3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELF3
    Clone
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): CELF3 (NM_007185)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CELF3
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    Primer
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    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CELF3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELF3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELF3

    Additional cDNA sequence: 

    AB209264.1 AF329264.1 AK123206.1 AK298852.1 AY165003.1 BC041088.1 BC052491.1 BC068008.1 
    BC104758.1 BC143226.1 U80746.1 U80759.1 

    3 DOTS entries:

    DT.95165299  DT.95165297  DT.100748144 

    24/60 AceView cDNA sequences (see all 60):

    BU181869 AA054399 BC068008 CA848369 CR595146 AK123206 AI627505 BC041088 
    BM273040 T08930 BG152489 BM680140 CA771111 AL519538 BE313111 BM724907 
    AW103734 BG910146 AL519587 NM_007185 BI467372 U80759 AY165003 BM353094 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CELF3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14
    SP1:                          -                                                                           
    SP2:                                                                                                      
    SP3:                          -                                                                           
    SP4:                                                                                                      
    SP5:                                                                                                      


    ECgene alternative splicing isoforms for CELF3

    Expression
    for CELF3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CELF3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTATGCTTC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CELF3 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainBlood Brain BarrierEndothelial CellsBlood Brain Barrier, Endothelium
    Gut TubeMidgutMidgut Endoderm CellsEndoderm
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    EyeRetinaEye
    Gut TubeMidgutGut Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CELF3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CELF3

    SOURCE GeneReport for Unigene cluster: Hs.26047

    UniProtKB/Swiss-Prot: CELF3_HUMAN, Q5SZQ8
    Tissue specificity: Expressed in brain

        SABiosciences Custom PCR Arrays for CELF3
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELF3

    Orthologs
    for CELF3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CELF3 gene from 8/25 species (see all 25)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CELF31 CUGBP, Elav-like family member 3 83.59(n)
    90.02(a)    		   431347  XM_003642699.1  XP_003642747.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CELF36
    CELF66
    (see all 3)    		 --
    		 90(a)
    72(a)
    (see all 3)    		 1 ↔ many
    possible ortholog
    (see all 3)    		 GL344222.1(4691-7736)
    GL343490.1(1292-14752)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC684372 hypothetical protein MGC68437 79.19(n)    U16800.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii etr12 etr1 77.3(n)   57922  BC060923.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta bru-36
    		 bruno-3
    		 48(a)
    		 possible ortholog
    		 3L(13515293-13796500)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-756
    		 UNCoordinated family member (unc-75)
    		 46(a)
    		 1 → many
    		 I(11592293-11601596)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AtRBP-DR16
    AT1G034576
    		 RNA recognition motif-containing protein
    		 34(a)
    34(a)
    		 many ↔ many
    many ↔ many
    		 4(1376306-1379420)
    1(860788-864125)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 RNA recognition motif containing protein, putative...
    RNA recognition motif containing protein, putative...
    (see all 3)    		 35(a)
    33(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 1(41192307-41197933)
    5(17934689-17940498)


    ENSEMBL Gene Tree for CELF3 (if available)
    TreeFam Gene Tree for CELF3 (if available) 

    Paralogs
    for CELF3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CELF3 gene
    CELF12  CELF42  CELF22  CELF62  CELF52  
    17 SIMAP similar genes for CELF3 using alignment to 5 protein entries:     CELF3_HUMAN (see all proteins):
    TNRC4    RBM4    BRUNOL4    CELF6    CELF5    CELF4
    BRUNOL6    CELF1    RBM47    HNRNPA1    RBMS1    RBM4B
    CELF2    RBMS2    MYEF2    TIAL1    ELAVL2

    CELF3 for paralogs           About GeneDecksing



    Genomic Variants
    for CELF3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CELF3_HUMAN, Q5SZQ8
    Polymorphism: The poly-Gln tract in AAK07474 may be polymorphic


    10/255 NCBI SNPs in CELF3 are shown (see all 255)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1874647541,2
    		--151672152(+) GAGGGG/TCTGGG 3 -- ds50010--------
    rs1428088241,2
    		--151672157(+) GCTGGA/GGCCTA 3 -- ds50010--------
    rs1916048111,2
    		--151672180(+) CAAGGA/GTATCT 3 -- ds50010--------
    rs1445217971,2
    		--151672247(+) GGTGGA/GTGAGA 3 -- ds50010--------
    rs1142699721,2
    		F,--151672302(+) ACTTCC/TGATCA 3 -- ds50011Minor allele frequency- T:0.05WA 118
    rs1480128241,2
    		--151672336(+) GACCAC/TAAGAC 3 -- ds50010--------
    rs1416639771,2
    		--151672351(+) GACCAC/TTGTGG 3 -- ds50010--------
    rs1849595011,2
    		--151672385(+) GAGACA/GTTGTT 3 -- ds50010--------
    rs758853461,2
    		C,F,--151672560(+) ATTTAT/CTAGGT 3 -- ut311Minor allele frequency- C:0.08WA 118
    rs34661,2
    		C,F,H,--151672658(+) AGGCTC/TACAGA 3 -- ut3130Minor allele frequency- T:0.22MN NA EA NS 3112

    HapMap Linkage Disequilibrium report for CELF3 (151672534 - 151689290 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CELF3: --

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    Disorders / Diseases
    for CELF3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CELF3 for disorders           About GeneDecksing

    OMIM gene information: 612678    OMIM disorders: --

    7 diseases for CELF3:    About MalaCards
    frontotemporal dementia    sporadic breast cancer    dementia    breast cancer
    ataxia    malaria    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: CELF3 (3 documents)

    Export disorders for CELF3 gene to outside databases

    Publications
    for CELF3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CELF3 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with CELF3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNAs with long CAG trinucleotide repeats from human brain. (PubMed id 9225980)1, 2, 3 Margolis R.L.... Ross C.A. (1997)
    2. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. (PubMed id 15009664)1, 2 Wang J....Andreadis A. (2004)
    3. The CELF family of RNA binding proteins is implicated in cell- specific and developmentally regulated alternative splicing. (PubMed id 11158314)1, 2 Ladd A.N.... Cooper T.A. (2001)
    4. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. (PubMed id 10893231)1, 2 Good P.J.... Herring D.C. (2000)
    5. Expression, localization and tau exon 10 splicing activity of the brain RNA-binding protein TNRC4. (PubMed id 17725984)1, 9 Chapple J.P....Gallo J.M. (2007)
    6. A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
    10. A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. (PubMed id 16713569)1 Lim J.... Zoghbi H.Y. (2006)

    External Searches for CELF3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CELF3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 11189 HGNC: 11967 AceView: TNRC4 Ensembl:ENSG00000159409 euGenes: HUgn11189
    ECgene: CELF3 H-InvDB: CELF3

    Other Databases showing CELF3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CELF3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CELF3 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CELF3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CELF3 gene:
    Search GeneIP for patents involving CELF3

    GeneCards and IP:
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