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CELF2 Gene

protein-coding   GIFtS: 61
GCID: GC10P011049

CUGBP, Elav-Like Family Member 2

(Previous names: CUG triplet repeat, RNA-binding protein 2, CUG triplet repeat,...)
(Previous symbol: CUGBP2)
  See CELF2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
CUGBP, Elav-Like Family Member 21 2     ETR-32 3
CUGBP21 2 3 5     NAPOR2 3
BRUNOL32 3 5     CUG Triplet Repeat RNA-Binding Protein 22 3
ETR32 3 5     CUG-BP- And ETR-3-Like Factor 22 3
CUG Triplet Repeat, RNA Binding Protein 21 2     ELAV-Type RNA-Binding Protein 32 3
Bruno-Like Protein 32 3     hNAPOR2 3
Neuroblastoma Apoptosis-Related RNA-Binding Protein2 3     RNA-Binding Protein BRUNOL-32 3
CELF-22 3     CUG Triplet Repeat, RNA-Binding Protein 21
CUG-BP22 3     CUGBP Elav-Like Family Member 22

External Ids:    HGNC: 25501   Entrez Gene: 106592   Ensembl: ENSG000000487407   OMIM: 6025385   UniProtKB: O953193   
ORGUL members:         

Export aliases for CELF2 gene to outside databases

Previous GC identifers: GC10P011048 GC10P010966


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CELF2 Gene:
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one
C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of
this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and
translation. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided
by RefSeq, Jul 2008)

GeneCards Summary for CELF2 Gene:
CELF2 (CUGBP, Elav-like family member 2) is a protein-coding gene. Diseases associated with CELF2 include neuroblastoma. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is CELF1.

UniProtKB/Swiss-Prot: CELF2_HUMAN, O95319
Function: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in
pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in
pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically
activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5
inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of
coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in
actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA.
Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in
epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating
COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR
of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the
TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs.
Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds
AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for
the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity)

Gene Wiki entry for CELF2 (CUGBP2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NT_008705.17  NC_018921.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CELF2
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CELF2 promoter sequence
   Search Chromatin IP Primers for CELF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CELF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10p13   Ensembl cytogenetic band:  10p14   HGNC cytogenetic band: 10p13

CELF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELF2 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P011049:  view genomic region     (about GC identifiers)

Start:
11,047,259 bp from pter      End:
11,378,674 bp from pter
Size:
331,416 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CELF2_HUMAN, O95319 (See protein sequence)
Recommended Name: CUGBP Elav-like family member 2  
Size: 508 amino acids; 54285 Da
Subunit: Interacts with A1CF (By similarity)
Developmental stage: Isoform 1 is expressed in fetal brain. Isoform 2 is expressed in fetal heart, brain, thymus,
lung, liver, skeletal muscle, kidney and spleen. Isoform 4 is expressed in fetal heart, brain, thymus, lung and
skeletal muscle
Secondary accessions: B7ZAN9 Q7KYU4 Q8N499 Q92950 Q96NW9 Q96RQ5 Q96RQ6 Q9UL67
Alternative splicing: 5 isoforms:  O95319-1   O95319-2   O95319-3   O95319-4   O95319-5   

Explore the universe of human proteins at neXtProt for CELF2: NX_O95319

Explore proteomics data for CELF2 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys83, Lys94, Lys190, Lys458
  • Modification sites at PhosphoSitePlus

  • See CELF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001020247.1  NP_001020248.1  NP_001077060.1  NP_006552.3  

    ENSEMBL proteins: 
     ENSP00000346426   ENSP00000315328   ENSP00000476999   ENSP00000476392   ENSP00000476656  
     ENSP00000346971   ENSP00000368563   ENSP00000406451   ENSP00000389951   ENSP00000443926  
     ENSP00000382743   ENSP00000404834   ENSP00000388530   ENSP00000438884  

    CELF2 Human Recombinant Protein Products:

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    Novus Biologicals CELF2 Proteins
    Novus Biologicals CELF2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CELF2 

     
    antibodies-online proteins for CELF2 (8 products) 

     
    antibodies-online peptides for CELF2

    CELF2 Antibody Products:

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    antibodies-online antibodies for CELF2 (29 products) 

    CELF2 Assay Products:

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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CELF2 
    antibodies-online kits for CELF2 (17 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    3 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom
     IPR002343 Hud_Sxl_RNA

    Graphical View of Domain Structure for InterPro Entry O95319

    ProtoNet protein and cluster: O95319

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: CELF2_HUMAN, O95319
    Similarity: Belongs to the CELF/BRUNOL family
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    Find genes that share domains with CELF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CELF2_HUMAN, O95319
    Function: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in
    pre-mRNA alternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in
    pre-mRNA that are subject to tissue-specific and developmentally regulated alternative splicing. Specifically
    activates exon 5 inclusion of TNNT2 in embryonic, but not adult, skeletal muscle. Activates TNNT2 exon 5
    inclusion by antagonizing the repressive effect of PTB. Acts as both an activator and repressor of a pair of
    coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of the non-muscle (NM) exon in
    actinin pre-mRNAs. Promotes inclusion of exonS 21 and exclusion of exon 5 of the NMDA receptor R1 pre-mRNA.
    Involved in the apoB RNA editing activity. Increases COX2 mRNA stability and inhibits COX2 mRNA translation in
    epithelial cells after radiation injury (By similarity). Modulates the cellular apoptosis program by regulating
    COX2-mediated prostaglandin E2 (PGE2) expression (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR
    of transcripts such as DMPK. Binds to the muscle-specific splicing enhancer (MSE) intronic sites flanking the
    TNNT2 alternative exon 5. Binds preferentially to UG-rich sequences, in particular UG repeat and UGUU motifs.
    Binds to apoB mRNA, specifically to AU-rich sequences located immediatly upstream of the edited cytidine. Binds
    AU-rich sequences in the 3'-UTR of COX2 mRNA (By similarity). Binds to an intronic RNA element responsible for
    the silencing of exon 21 splicing (By similarity). Binds to (CUG)n repeats (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS9887331
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with CELF2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CELF2:
     Synthetic lethal with imatinib 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CELF2

    miRNA
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    miRTarBase miRNAs that target CELF2:
    hsa-mir-324-5p (MIRT043173), hsa-mir-375 (MIRT020050), hsa-let-7e-5p (MIRT051430), hsa-mir-425-5p (MIRT016668)

    Block miRNA regulation of human, mouse, rat CELF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CELF2 (see all 252):
    hsa-miR-124* hsa-miR-140-5p hsa-miR-361-5p hsa-miR-376b hsa-miR-106a hsa-miR-146a hsa-miR-199a-3p hsa-miR-134
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CELF2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 4): CELF2 (NM_001025077)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELF2

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CELF2_HUMAN, O95319: Nucleus. Cytoplasm. Note=Accumulates in the cytoplasm after ionizing radiation (By
    similarity). Colocalizes with APOBEC1 and A1CF. RNA-binding activity is detected in both nuclear and cytoplasmic
    compartments
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with CELF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CELF2 About    
    See pathways by source

    SuperPathContained pathways About
    1mRNA Splicing - Major Pathway
    mRNA processing0.44


    1 BioSystems Pathway for CELF2
        mRNA processing


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CELF2
    Interactions:

        Search GeneGlobe Interaction Network for CELF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CELF2 (O953192, 3 ENSP000003899514) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCBP1Q153652, 3, ENSP000003055564MINT-2868675 I2D: score=3 STRING: ENSP00000305556
    APOBEC1P412383, ENSP000002293044I2D: score=1 STRING: ENSP00000229304
    A1CFQ9NQ943, ENSP000002826414I2D: score=2 STRING: ENSP00000282641
    GRB2P629933, ENSP000003390074I2D: score=1 STRING: ENSP00000339007
    BECN1ENSP000003552314STRING: ENSP00000355231
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006376mRNA splice site selection ----
    GO:0006396RNA processing TAS9887331
    GO:0006397mRNA processing IEA--
    GO:0008016regulation of heart contraction TAS9887331

    Find genes that share ontologies with CELF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CELF2

    2 HMDB Compounds for CELF2    About this table
    CompoundSynonyms CAS #PubMed Ids
    Cytidine1-(b-D-Ribofuranosyl)-2-oxo-4-amino-1,2-dihydro-1,3-diazine (see all 20)65-46-3--
    Prostaglandin E2(-)-Prostaglandin E2 (see all 22)363-24-6--

    1 Novoseek inferred chemical compound relationship for CELF2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    iron 6.11 1 7585245 (1)



    Find genes that share compounds with CELF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CELF2 gene (4 alternative transcripts): 
    NM_001025076.2  NM_001025077.2  NM_001083591.1  NM_006561.3  

    Unigene Cluster for CELF2:

    CUGBP, Elav-like family member 2
    Hs.309288  [show with all ESTs]
    Unigene Representative Sequence: NM_001025077
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000354440(uc001ikk.2 uc010qbl.1 uc010qbp.1) ENST00000315874(uc010qbk.1 uc010qbm.1)
    ENST00000608830 ENST00000609870 ENST00000609692 ENST00000354897 ENST00000379261(uc010qbi.2 uc010qbj.1 uc001iki.4)
    ENST00000416382 ENST00000450189(uc001ikl.4) ENST00000542579 ENST00000399850(uc010qbo.1)
    ENST00000417956(uc009xiw.1) ENST00000427450(uc001iko.4 uc001ikp.4)
    ENST00000537122
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CELF2 (see all 252):
    hsa-miR-124* hsa-miR-140-5p hsa-miR-361-5p hsa-miR-376b hsa-miR-106a hsa-miR-146a hsa-miR-199a-3p hsa-miR-134
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      QuantiFast Probe-based Assays in human, mouse, rat CELF2

    Additional mRNA sequence: 

    AF036956.1 AF086447.1 AF090693.1 AF090694.1 AF432906.1 AK293164.1 AK295511.1 AK297313.1 
    AK297380.1 AK299548.1 AK299983.1 AK299992.1 AK302681.1 AK304216.1 AK310038.1 AK314087.1 
    AK316354.1 BC036391.1 BC050635.1 BX647703.1 CR936676.1 U69546.1 

    Selected DOTS entries (see all 33):

    DT.444499  DT.101960230  DT.95074009  DT.97819078  DT.95255913  DT.100030160  DT.91750926  DT.101969833 
    DT.121262991  DT.91653315  DT.100823247  DT.121263174  DT.216871  DT.97855182  DT.121263144  DT.216872 
    DT.91750927  DT.121262966  DT.121263151  DT.121263069  DT.40117190  DT.91833505  DT.92058076  DT.100823254 

    Selected AceView cDNA sequences (see all 451):

    BM671832 W70053 AA670420 AL133765 BE894472 BM473904 BF510414 BM699598 
    AI783598 BX643214 BU736216 BC050635 AI064950 AI707797 BX483433 BQ718002 
    BM719338 AA744702 AA403114 BM667569 BM680801 AA450229 AA213736 AI655910 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CELF2 (see all 8)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b · 18c ^ 19
    SP1:                    -           -     -           -                 -                                   -     -                             -     -         
    SP2:              -     -           -     -           -                 -                                               -                                       
    SP3:              -     -           -     -           -                 -                                   -     -                             -     -         
    SP4:                                -     -           -                 -                                   -     -     -                                       
    SP5:              -     -           -     -                                                                                                                     


    ECgene alternative splicing isoforms for CELF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CELF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAACGTTTCT
    CELF2 Expression
    About this image


    CELF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 14) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Epithalamus
     
     Limb (Muscoskeletal System)    fully expand to see all 3 entries
             Apical Ectodermal Ridge Cells Limb Ectoderm
             Limb Bud
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Telencephalon
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    CELF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CELF2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.309288

    UniProtKB/Swiss-Prot: CELF2_HUMAN, O95319
    Tissue specificity: Expressed in frontal cortex. Isoform 1 is expressed in brain and lung. Isoform 2 is expressed
    in heart, brain, placenta, lung, liver, kidney, skeletal muscle and pancreas. Isoform 4 is expressed in heart,
    lung, skeletal muscle, kidney and pancreas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CELF2 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Celf21 , 5 CUGBP, Elav-like family member 21, 5 94.69(n)1
    99.8(a)1
      2 (3.69 cM)5
    140071  NM_001110231.11  NP_001103701.11 
     65396945 
    chicken
    (Gallus gallus)
    Aves CELF21 CUGBP, Elav-like family member 2 89.41(n)
    97.95(a)
      374111  NM_204260.1  NP_989591.1 
    lizard
    (Anolis carolinensis)
    Reptilia CELF26
    CUGBP, Elav-like family member 2
    99(a)
    1 ↔ 1
    5(5565454-5753670)
    African clawed frog
    (Xenopus laevis)
    Amphibia U69547.12   -- 86.85(n)    U69547.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AB050496.12   -- 79.96(n)   373117  AB050496.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bru-21 bruno-2 57.59(n)
    58.69(a)
      250811  NM_001273481.1  NP_001260410.1 
    worm
    (Caenorhabditis elegans)
    Secernentea etr-11 etr-1 50.99(n)
    49.67(a)
      173401  NM_001129160.2  NP_001122632.1 
    soybean
    (Glycine max)
    eudicotyledons Gma.130492 Transcribed sequence with weak similarity to protein more 70.48(n)    BE823467.1 
    corn
    (Zea mays)
    Liliopsida AY104506.12   -- 72.03(n)    AY104506.1 


    ENSEMBL Gene Tree for CELF2 (if available)
    TreeFam Gene Tree for CELF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CELF2 gene
    CELF12  CELF42  CELF32  CELF62  CELF52  ENSG000002730252  
    15 SIMAP similar genes for CELF2 using alignment to 6 protein entries:     CELF2_HUMAN (see all proteins):
    CELF1    RBMS1    TNRC4    CELF3    RBMX    CELF6
    ELAVL2    RBMY1A1    CELF4    CIRBP    MSI2    BOLL
    RBM4B    CELF5    TIAL1

    Find genes that share paralogs with CELF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CELF2 (see all 7518)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1826434551,2
    C--10955911(+) CATATA/GCTACA 1 -- us2k10--------
    rs115955831,2
    C,H--10955999(+) GTTTAG/TCCCCC 1 -- us2k14Minor allele frequency- T:0.00NS EA 418
    rs1876070261,2
    --10956210(+) TAACCA/GCTGGA 1 -- us2k10--------
    rs1928093161,2
    --10956278(+) CAAGGC/TGAATG 1 -- us2k10--------
    rs1462577521,2
    C--10956296(+) ACTGTC/TTCTCC 1 -- us2k10--------
    rs1825005851,2
    --10956307(+) CTAAGA/TTCTCT 1 -- us2k10--------
    rs1871513381,2
    --10956353(+) CTTCAA/CAAGAA 1 -- us2k10--------
    rs1920114401,2
    --10956392(+) CTGGCA/GAGGTT 1 -- us2k10--------
    rs2017826381,2
    C--10956464(-) CCCCAA/TTNNNN 1 -- us2k10--------
    rs1392034581,2
    --10956590(+) CATAGC/TCCAGC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CELF2 (11047259 - 11297259 bp, first 250kb of CELF2)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CELF2 (see all 18):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732951CNV Deletion23290073
    esv2732918CNV Deletion23290073
    esv1683473CNV Deletion17803354
    esv2732929CNV Deletion23290073
    esv2043576CNV Deletion18987734
    esv2732940CNV Deletion23290073
    esv2495762CNV Insertion19546169
    nsv5798CNV Insertion18451855
    nsv507539CNV Insertion20534489
    nsv24299CNV Insertion16902084

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602538    OMIM disorders: --

    1 disease for CELF2:    
    About MalaCards
    neuroblastoma


    Find genes that share disorders with CELF2           About GenesLikeMe

    2 Novoseek inferred disease relationships for CELF2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myotonic dystrophy 52.1 1 9887331 (1)
    tumors 0 1 15489060 (1)

    Genetic Association Database (GAD): CELF2
    Human Genome Epidemiology (HuGE) Navigator: CELF2 (0 documents)

    Export disorders for CELF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CELF2 gene, integrated from 10 sources (see all 68):
    (articles sorted by number of sources associating them with CELF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization and isoform-specific tissue expression of human NAPOR (CUGBP2) as a candidate gene for familial arrhythmogenic right ventricular dysplasia. (PubMed id 11414768)1, 2, 9 Li D.... Roberts R. (Genomics 2001)
    2. Cardiac elav-type RNA-binding protein (ETR-3) binds to RNA CUG repeats expanded in myotonic dystrophy. (PubMed id 9887331)1, 3, 9 Lu X....Timchenko L.T. (Hum. Mol. Genet. 1999)
    3. Identification of CELF splicing activation and repression domains in vivo. (PubMed id 15894795)1, 2, 9 Han J. and Cooper T.A. (Nucleic Acids Res. 2005)
    4. Developmentally-regulated expression of mNapor encoding an apoptosis- induced ELAV-type RNA binding protein. (PubMed id 10524244)1, 2, 9 Choi D.-K.... Sakaki Y. (Gene 1999)
    5. A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. (PubMed id 10893231)1, 2, 9 Good P.J.... Herring D.C. (J. Biol. Chem. 2000)
    6. ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo. (PubMed id 14973222)1, 2 Singh G.... Cooper T.A. (Nucleic Acids Res. 2004)
    7. The CELF family of RNA binding proteins is implicated in cell- specific and developmentally regulated alternative splicing. (PubMed id 11158314)1, 2 Ladd A.N.... Cooper T.A. (Mol. Cell. Biol. 2001)
    8. Novel role for RNA-binding protein CUGBP2 in mammalian RNA editing. CUGBP2 modulates C to U editing of apolipoprotein B mRNA by interacting with apobec-1 and ACF, the apobec-1 complementation factor. (PubMed id 11577082)1, 2 Anant S.... Davidson N.O. (J. Biol. Chem. 2001)
    9. Single pass sequencing of a unidirectional human fetal heart cDNA library to discover novel genes of the cardiovascular system. (PubMed id 7869393)1, 3 Hwang D.M....Liew C.C. (J. Mol. Cell. Cardiol. 1994)
    10. Fluorescent differential display analysis of gene expression in apoptotic neuroblastoma cells. (PubMed id 9858671)2, 9 Choi D.-K.... Sakaki Y. (Gene 1998)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10659 HGNC: 2550 AceView: CUGBP2 Ensembl:ENSG00000048740 euGenes: HUgn10659
    ECgene: CELF2 H-InvDB: CELF2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CELF2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CELF2 gene:
    Search GeneIP for patents involving CELF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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