CELF1 Gene
protein-coding GIFtS: 56
GCID: GC11M048078
|
|
CUGBP, Elav-like family member 1(Previous names: CUG triplet repeat, RNA-binding protein 1, CUG triplet...)
(Previous symbol: CUGBP1)
| |
Aliases
for CELF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| CUGBP, Elav-Like Family Member 11 2 | | Embryo Deadenylation Element-Binding Protein Homolog2 3 | | BRUNOL21 2 3 5 | | 50 KDa Nuclear Polyadenylated RNA-Binding Protein2 3 | | CUGBP1 2 3 5 | | CELF-12 3 | | CUGBP11 2 3 5 | | CUG-BP12 3 | | NAB501 2 3 5 | | CUG Triplet Repeat RNA-Binding Protein 12 3 | | CUG-BP1 2 | | CUG-BP- And ETR-3-Like Factor 12 3 | | EDEN-BP1 2 | | EDEN-BP Homolog2 3 | | NAPOR1 2 | | RNA-Binding Protein BRUNOL-22 3 | | CUG Triplet Repeat, RNA Binding Protein 11 2 | | Bruno-Like 22 | | CUG Triplet Repeat, RNA-Binding Protein 11 2 | | CUG RNA-Binding Protein2 | | HNab501 | | CUGBP Elav-Like Family Member 12 | | Bruno-Like Protein 22 3 | | Embryo Deadenylation Element Binding Protein2 | | Deadenylation Factor CUG-BP2 3 | | Nuclear Polyadenylated RNA-Binding Protein, 50-KD2 |
Export aliases for CELF1 gene to outside databasesPrevious GC identifers: GC11M047489 GC11M047187 GC11M047602 |
Summaries
for CELF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CELF1:
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminalRRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this proteinfamily regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene mayplay a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK)gene. Alternative splicing results in multiple transcript variants encoding different isoforms. (provided by RefSeq,Jul 2008)
UniProtKB/Swiss-Prot: CELF1_HUMAN, Q92879Function: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNAalternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that aresubject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusionof cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activatorand repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of thenon-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB.Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNAexon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPBmRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA byantagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylasePARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion ofspermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and toBruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking thealternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUNand FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region ofCEBPB mRNA in aging liver
Gene Wiki entry for CELF1 (CUGBP1)
|
Genomic Views
for CELF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CELF1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CELF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p11 Ensembl cytogenetic band: 11p11.2 HGNC cytogenetic band: 11p11CELF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M048078: view genomic region
(about GC identifiers)
Start:
|
47,487,489 bp from pter |
End:
|
47,587,121 bp from pter |
Size:
|
99,633 bases |
Orientation:
|
minus strand |
|
Proteins
for CELF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CELF1_HUMAN, Q92879 (See
protein sequence)Recommended Name: CUGBP Elav-like family member 1 Size: 486 amino acids; 52063 Da
Subunit: Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 andHSPA5. Associates with polysomes (By similarity). Interacts with HNRNPH1; the interaction in RNA-dependent. Interactswith PARN
Subcellular location: Nucleus. Cytoplasm. Note=RNA-binding activity is detected in both nuclear and cytoplasmiccompartments
Sequence caution: Sequence=BAE06101.1; Type=Erroneous initiation;
6/8 PDB 3D structures from  and Proteopedia  for CELF1 (see all 8):2CPZ (3D)
2DHS (3D)
2RQ4 (3D)
2RQC (3D)
3NMR (3D)
3NNA (3D)
Secondary accessions: B4E2U5 D3DQS0 F8W940 Q4LE52 Q9NP83 Q9NR06Alternative splicing: 5 isoforms: Q92879-1 Q92879-2 Q92879-3 Q92879-4 Q92879-5 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CELF1: NX_Q92879
Post-translational modifications:
Phosphorylated. Its phosphorylation status increases in senescent cells1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92879
CELF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001020767.1 NP_001166110.1 NP_001166111.1 NP_006551.1 NP_941989.1
ENSEMBL proteins: ENSP00000351409 ENSP00000378706 ENSP00000308386 ENSP00000354639 ENSP00000436864 ENSP00000435926 ENSP00000433986 ENSP00000435320 ENSP00000436191 ENSP00000444825 ENSP00000438044 ENSP00000435423 ENSP00000442415 ENSP00000438862 ENSP00000378705
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
CELF1 for ontologies About GeneDecksing
CELF1 Antibody Products:
Assay Products for CELF1: |
Protein
Domains /
Families
for CELF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CELF1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q92879ProtoNet protein and cluster: Q92879 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: CELF1_HUMAN, Q92879Domain: RRM1 and RRM2 domains preferentially target UGU(U/G)-rich mRNA elementsSimilarity: Belongs to the CELF/BRUNOL familySimilarity: Contains 3 RRM (RNA recognition motif) domains |
Function
for CELF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CELF1_HUMAN, Q92879Function: RNA-binding protein implicated in the regulation of several post-transcriptional events. Involved in pre-mRNAalternative splicing, mRNA translation and stability. Mediates exon inclusion and/or exclusion in pre-mRNA that aresubject to tissue-specific and developmentally regulated alternative splicing. Specifically activates exon 5 inclusionof cardiac isoforms of TNNT2 during heart remodeling at the juvenile to adult transition. Acts as both an activatorand repressor of a pair of coregulated exons: promotes inclusion of the smooth muscle (SM) exon but exclusion of thenon-muscle (NM) exon in actinin pre-mRNAs. Activates SM exon 5 inclusion by antagonizing the repressive effect of PTB.Promotes exclusion of exon 11 of the INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor (IR) pre-mRNAexon 11 inclusion in myoblast. Increases translation and controls the choice of translation initiation codon of CEBPBmRNA. Increases mRNA translation of CEBPB in aging liver (By similarity). Increases translation of CDKN1A mRNA byantagonizing the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA deadenylation. Recruits the deadenylasePARN to the poly(A) tail of EDEN-containing mRNAs to promote their deadenylation. Required for completion ofspermatogenesis (By similarity). Binds to (CUG)n triplet repeats in the 3'-UTR of transcripts such as DMPK and toBruno response elements (BREs). Binds to muscle-specific splicing enhancer (MSE) intronic sites flanking thealternative exon 5 of TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like) localized in the 3'-UTR of JUNand FOS mRNAs. Binds to the IR RNA. Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the 5'-region ofCEBPB mRNA in aging liverInduction: Up-regulated in myotonic dystrophy pathophysiology (DM)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELF1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELF1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): CELF1 (NM_001025596) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CELF1 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELF1 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELF1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CELF1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CELF1:
Animal Models:
5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Celf1):
CELF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CELF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Adipogenesis | | | 2 | mRNA Splicing - Major Pathway | |
2  BioSystems Pathways for CELF1
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 10)
5/16 Interacting proteins for CELF1 (Q928792, 3 ENSP000003514094) via UniProtKB, MINT, STRING, and/or I2D (see all 16)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
CELF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CELF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CELF1 for compounds About GeneDecksing
 Browse Tocris compounds for CELF1
2 Novoseek chemical compound relationships for CELF1 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| chlordiazepoxide |
67.2 |
18 |
16836486 (6), 9427761 (4), 15181172 (2) |
| adenylate |
42.3 |
3 |
16601207 (1), 12799066 (1) |
Search CenterWatch for drugs/clinical trials and news about CELF1
|
Transcripts
for CELF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CELF1 gene (5 alternative transcripts): NM_001025596.2 NM_001172639.1 NM_001172640.1 NM_006560.3 NM_198700.2 Unigene Cluster for CELF1: CUGBP, Elav-like family member 1 Hs.595333 [show with all ESTs]Unigene Representative Sequence: NM_00117264018/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000358597 ENST00000395292 ENST00000310513 ENST00000361904 ENST00000539455
ENST00000531165(uc001nfr.1) ENST00000532048 ENST00000524648 ENST00000539254
ENST00000534614 ENST00000422993 ENST00000532146 ENST00000530151 ENST00000528434
ENST00000525841 ENST00000543178 ENST00000535982 ENST00000526419
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELF1 (see all 8)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELF1 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): CELF1 (NM_001025596) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CELF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELF1 |
Additional cDNA sequence: AB210019.1 AF267533.1 AF267534.1 AJ007988.1 AK054655.1 AK057016.1 AK304430.1 AK307679.1 BC031079.1 U63289.1 24/43 DOTS entries (see all 43): DT.92443522 DT.40256275 DT.95080852 DT.120735737 DT.120735706 DT.97785318 DT.100733058 DT.441853 DT.100027709 DT.95142833 DT.120735694 DT.91688359 DT.92440575 DT.97857015 DT.100823706 DT.100823704 DT.120735763 DT.120735755 DT.120735822 DT.100737554 DT.120735740 DT.120735730 DT.92440569 DT.120735709 24/530 AceView cDNA sequences (see all 530): BU501885 BU742498 BM756872 BC036782 AL560590 BM700425 CB266635 BU687229 BQ012288 BQ083080 AF248648 BQ424007 AA341569 BM510632 AK056024 AI095508 BQ379328 BM874781 BM823316 BG819859 BF727387 AI089440 AA846196 BE349471
GeneLoc Exon Structure
5/21 Alternative Splicing Database (ASD) splice patterns (SP) for CELF1 (see all 21) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c | · | 12d | · | 12e | · | 12f | ^ | 13 | ^ | 14 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 15a | · | 15b | ^ | 16a | · | 16b | · | 16c | ^ | 17a | · | 17b | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 |
|---|
|
| SP1: | | | | | - | | | | | | - | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | - | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | - | | | | | | - | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CELF1
|
Expression
for CELF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CELF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGGGATTTT
About this image
See CELF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CELF1
SOURCE GeneReport for Unigene cluster: Hs.595333
UniProtKB/Swiss-Prot: CELF1_HUMAN, Q92879Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for CELF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CELF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CELF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELF1 |
Orthologs
for CELF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CELF1 gene from 8/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
CELF11 |
CUGBP, Elav-like family member 1 |
85.24(n)
96.88(a) |
|
373923 NM_001012521.1 NP_001012539.1 |
lizard
(Anolis carolinensis) |
Reptilia |
CELF16 |
-- |
96(a) |
1 ↔ 1 |
1(44225658-44243831) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.259212 |
Xenopus laevis embryo deadenylation element binding more |
81.24(n) |
|
AF003923.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
cugbp12 |
CUG triplet repeat, RNA-binding protein 1 |
77.41(n) |
|
58137 BC049453.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
bru-21 |
bruno-2 |
54.8(n)
55.33(a) |
|
250811 NM_176025.2 NP_788039.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
etr-11 |
Protein ETR-1 |
51.51(n)
51.58(a) |
|
173401 NM_061272.4 NP_493673.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G034576AtRBP-DR16 |
RNA-binding protein-defense related 1 |
31(a)30(a) |
many ↔ manymany ↔ many |
1(860788-864125) 4(1376306-1379420) |
rice
(Oryza sativa) |
Liliopsida |
Os.336862 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
75.72(n) |
|
AK099501.1 |
ENSEMBL Gene Tree for CELF1 (if available)
TreeFam Gene Tree for CELF1 (if available) |
Paralogs
for CELF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CELF1 gene
- CELF42 CELF22 CELF32 CELF62 CELF52
18/22 SIMAP similar genes for CELF1 using alignment to 10 protein entries: CELF1_HUMAN (see all proteins)
(see all similar genes):CELF2 CELF3 CELF6 RBM4 TNRC4 RBM4B
BRUNOL6 CELF5 DAZAP1 HNRNPA1 CELF4 CIRBP
SRSF2 RBMS2 BOLL RBMX A1CF RBMY1J
CELF1 for paralogs About GeneDecksing
|
Genomic Variants
for CELF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CELF1 (47487489 - 47587121 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CELF1
1 CNV: 4741 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CELF1 |
|
Disorders
/ Diseases
for CELF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CELF1 for disorders About GeneDecksing
OMIM gene information: 601074
OMIM disorders: --
5  diseases for CELF1: About MalaCardsmyotonic dystrophy type 1 myotonic dystrophy insulin resistance neurofibromatosis
malaria
1 disease from the University of Copenhagen DISEASES database for CELF1:Myotonic dystrophy 3 Novoseek disease relationships for CELF1 gene About this table
Export disorders for CELF1 gene to outside databases
|
Publications
for CELF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CELF1 gene, integrated from 9 sources (see all 91):
(articles sorted by number of sources associating them with CELF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy. (PubMed id 8948631)1, 2, 3, 9 Timchenko L.T.... Swanson M.S. (1996)
- RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1. (PubMed id 11124939)1, 2, 9 Timchenko N.A....Timchenko L.T. (2001)
- A functional deadenylation assay identifies human CUG-BP as a deadenylation factor. (PubMed id 12799066)1, 2, 9 Paillard L.... Beverley Osborne H. (2003)
- CUG-BP binds to RNA substrates and recruits PARN deadenylase. (PubMed id 16601207)1, 2, 9 Moraes K.C.... Wilusz J. (2006)
- Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing. (PubMed id 16946708)1, 2, 9 Paul S....Reddy S. (2006)
- Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells. (PubMed id 11686919)1, 2, 9 Takahashi N.... Ishiura S. (2001)
- The CELF family of RNA binding proteins is implicated in cell- specific and developmentally regulated alternative splicing. (PubMed id 11158314)1, 2, 9 Ladd A.N.... Cooper T.A. (2001)
- A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator. (PubMed id 10893231)1, 2, 9 Good P.J.... Herring D.C. (2000)
- Altered phosphorylation and intracellular distribution of a (CUG)n triplet repeat RNA-binding protein in patients with myotonic dystrophy and in myotonin protein kinase knockout mice. (PubMed id 9371827)1, 3, 9 Roberts R....Timchenko L.T. (1997)
- Structural insights into RNA recognition by the alter nate-splicing regulator CUG-binding protein 1. (PubMed id 20947024)1, 2 Teplova M....Patel D.J. (2010)
|
External Searches for CELF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CELF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CELF1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CELF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CELF1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CELF1 gene:
Search GeneIP for patents involving CELF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CELF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for CELF1 | | OriGene shRNA RFP for CELF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CELF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CELF1 | | | OriGene Protein Over-expression Lysate for CELF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CELF1 | | OriGene 3'-UTR Clone for CELF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CELF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CELF1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CELF1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELF1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELF1 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELF1 |
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