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Aliases for CELA3B Gene

Aliases for CELA3B Gene

  • Chymotrypsin-Like Elastase Family, Member 3B 2 3
  • Cholesterol-Binding Pancreatic Protease 2 3
  • Pancreatic Endopeptidase E 2 3
  • Elastase 3B, Pancreatic 2 3
  • Elastase IIIB 3 4
  • Proteinase E 2 3
  • Elastase-3B 3 4
  • Elastase 1 2 3
  • Protease E 3 4
  • ELA3B 3 4
  • Pancreatic Elastase 1 3
  • Fecal Elastase 1 3
  • EC 3.4.21.70 4
  • EC 3.4.21 63
  • CBPP 3
  • EL-1 3
  • E1 3

External Ids for CELA3B Gene

Previous HGNC Symbols for CELA3B Gene

  • ELA3B

Previous GeneCards Identifiers for CELA3B Gene

  • GC01P022178
  • GC01P022303
  • GC01P020547

Summaries for CELA3B Gene

Entrez Gene Summary for CELA3B Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

GeneCards Summary for CELA3B Gene

CELA3B (Chymotrypsin-Like Elastase Family, Member 3B) is a Protein Coding gene. Diseases associated with CELA3B include actinobacillosis and pancreatic steatorrhea. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is CELA2B.

UniProtKB/Swiss-Prot for CELA3B Gene

  • Efficient protease with alanine specificity but only little elastolytic activity

Gene Wiki entry for CELA3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA3B Gene

Genomics for CELA3B Gene

Regulatory Elements for CELA3B Gene

Genomic Location for CELA3B Gene

Chromosome:
1
Start:
21,976,925 bp from pter
End:
21,998,642 bp from pter
Size:
21,718 bases
Orientation:
Plus strand

Genomic View for CELA3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELA3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA3B Gene

Proteins for CELA3B Gene

  • Protein details for CELA3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08861-CEL3B_HUMAN
    Recommended name:
    Chymotrypsin-like elastase family member 3B
    Protein Accession:
    P08861
    Secondary Accessions:
    • B2RE44
    • P11423
    • Q5VU28
    • Q5VU29
    • Q5VU30

    Protein attributes for CELA3B Gene

    Size:
    270 amino acids
    Molecular mass:
    29263 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH71872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CELA3B Gene

Proteomics data for CELA3B Gene at MOPED

Selected DME Specific Peptides for CELA3B Gene

Post-translational modifications for CELA3B Gene

  • Glycosylation at Asn 114
  • Modification sites at PhosphoSitePlus

Other Protein References for CELA3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CELA3B Gene

Suggested Antigen Peptide Sequences for CELA3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08861

UniProtKB/Swiss-Prot:

CEL3B_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA3B: view

No data available for Gene Families for CELA3B Gene

Function for CELA3B Gene

Molecular function for CELA3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin
UniProtKB/Swiss-Prot Function:
Efficient protease with alanine specificity but only little elastolytic activity

Enzyme Numbers (IUBMB) for CELA3B Gene

Gene Ontology (GO) - Molecular Function for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 2737288
GO:0008233 peptidase activity TAS 2460440
genes like me logo Genes that share ontologies with CELA3B: view
genes like me logo Genes that share phenotypes with CELA3B: view

Animal Model Products

miRNA for CELA3B Gene

miRTarBase miRNAs that target CELA3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELA3B

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CELA3B Gene

Localization for CELA3B Gene

Gene Ontology (GO) - Cellular Components for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CELA3B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for CELA3B Gene

Pathways & Interactions for CELA3B Gene

genes like me logo Genes that share pathways with CELA3B: view

Pathways by source for CELA3B Gene

2 KEGG pathways for CELA3B Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat

Interacting Proteins for CELA3B Gene

Gene Ontology (GO) - Biological Process for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008203 cholesterol metabolic process TAS 2826474
genes like me logo Genes that share ontologies with CELA3B: view

No data available for SIGNOR curated interactions for CELA3B Gene

Drugs & Compounds for CELA3B Gene

(1) Drugs for CELA3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvelestat Pharma NE inhibitor 0
genes like me logo Genes that share compounds with CELA3B: view

Transcripts for CELA3B Gene

Unigene Clusters for CELA3B Gene

Chymotrypsin-like elastase family, member 3B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELA3B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CELA3B Gene

No ASD Table

Relevant External Links for CELA3B Gene

GeneLoc Exon Structure for
CELA3B
ECgene alternative splicing isoforms for
CELA3B

Expression for CELA3B Gene

mRNA expression in normal human tissues for CELA3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA3B Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for CELA3B Gene

This gene is overexpressed in Pancreatic juice (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CELA3B Gene



SOURCE GeneReport for Unigene cluster for CELA3B Gene Hs.728752

mRNA Expression by UniProt/SwissProt for CELA3B Gene

P08861-CEL3B_HUMAN
Tissue specificity: Pancreas. Not detectable in keratinocytes.
genes like me logo Genes that share expression patterns with CELA3B: view

Protein tissue co-expression partners for CELA3B Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CELA3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CELA3B 35
  • 84.57 (n)
  • 85.93 (a)
CELA3B 36
  • 86 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CELA3B 35
  • 85.38 (n)
  • 85.5 (a)
-- 36
  • 85 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cela3b 35
  • 83.15 (n)
  • 84.39 (a)
Cela3b 16
Cela3b 36
  • 84 (a)
ManyToMany
Gm13011 36
  • 73 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia CELA3B 35
  • 99.01 (n)
  • 99.63 (a)
rat
(Rattus norvegicus)
Mammalia Cela3b 35
  • 83.52 (n)
  • 82.9 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100857116 35
  • 67.16 (n)
  • 65.84 (a)
-- 36
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 71 (a)
ManyToMany
-- 36
  • 72 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494627 35
  • 67.19 (n)
  • 65.75 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-44m9.5 36
  • 67 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for CELA3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA3B Gene

ENSEMBL:
Gene Tree for CELA3B (if available)
TreeFam:
Gene Tree for CELA3B (if available)

Paralogs for CELA3B Gene

Paralogs for CELA3B Gene

genes like me logo Genes that share paralogs with CELA3B: view

Variants for CELA3B Gene

Sequence variations from dbSNP and Humsavar for CELA3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1803530 -- 21,986,668(+) TTCAT(C/T)GACTG synonymous-codon, reference, nc-transcript-variant
rs1803531 -- 21,984,331(+) TGCAA(C/T)GTGAG synonymous-codon, reference, nc-transcript-variant
rs2473312 -- 21,989,810(-) CTCCT(C/G/T)TAAAA downstream-variant-500B, intron-variant
rs2501267 -- 21,989,780(-) GAATG(A/G)ATGAA downstream-variant-500B, intron-variant
rs2501268 -- 21,989,740(-) GCAGA(A/T)CACAC downstream-variant-500B, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CELA3B Gene

Variant ID Type Subtype PubMed ID
nsv834402 CNV Loss 17160897
nsv870552 CNV Loss 21882294
nsv469549 CNV Loss 16826518
nsv470706 CNV Loss 18288195
dgv43e1 CNV Complex 17122850
nsv834413 CNV Loss 17160897
nsv871504 CNV Gain 21882294
esv2745119 CNV Deletion 23290073
esv24116 CNV Loss 19812545
nsv436921 CNV Insertion 17901297
esv2672264 CNV Deletion 23128226
dgv21e201 CNV Deletion 23290073
esv7729 CNV Loss 19470904
nsv9657 CNV Loss 18304495

Variation tolerance for CELA3B Gene

Residual Variation Intolerance Score: 97.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CELA3B Gene

HapMap Linkage Disequilibrium report
CELA3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA3B Gene

Disorders for CELA3B Gene

MalaCards: The human disease database

(5) MalaCards diseases for CELA3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
actinobacillosis
  • actinobacillosis, nos
pancreatic steatorrhea
  • pancreatic steatorrhoea
glanders
  • farcy pipes
pleuropneumonia
  • pleurobronchopneumonia
pancreas disease
  • pancreatic diseases
- elite association

Relevant External Links for CELA3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CELA3B
genes like me logo Genes that share disorders with CELA3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CELA3B Gene

Publications for CELA3B Gene

  1. Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. (PMID: 20428826) Gao J. … Ma L. (Oncol. Rep. 2010) 23 67
  2. Chymotrypsin C (caldecrin) promotes degradation of human cationic trypsin: identity with Rinderknecht's enzyme Y. (PMID: 17592142) Szmola R. … Sahin-TA^th M. (Proc. Natl. Acad. Sci. U.S.A. 2007) 23 67
  3. Alterations in the renal elastin-elastase system in type 1 diabetic nephropathy identified by proteomic analysis. (PMID: 14978167) Thongboonkerd V. … Klein J.B. (J. Am. Soc. Nephrol. 2004) 23 67
  4. Elastase in intestinal mucus enhances the cytotoxicity of Shiga toxin type 2d. (PMID: 10652371) Kokai-Kun J.F. … O'Brien A.D. (J. Biol. Chem. 2000) 23 67
  5. Identification of a novel bone/calcium metabolism-regulating factor in porcine pancreas. (PMID: 8798519) Izbicka E. … Mundy G.R. (J. Biol. Chem. 1996) 23 67

Products for CELA3B Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CELA3B
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CELA3B
    • Block miRNA regulation of CELA3B using miScript Target Protectors

    Sources for CELA3B Gene

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