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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CELA3B Gene

protein-coding   GIFtS: 49
GCID: GC01P022303

chymotrypsin-like elastase family, member 3B

(Previous names: elastase 3B, pancreatic )
(Previous symbol: ELA3B)
 Explore 19 diseases affiliated with
CELA3B via our new
 Human Malady Compendium 
Biological research products
for CELA3B
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Chymotrypsin-Like Elastase Family, Member 3B1 2     Elastase 12
ELA3B1 2 3     Elastase-3B3
CBPP1 2     Fecal Elastase 12
Elastase 3B, Pancreatic1 2     Pancreatic Elastase 12
Elastase IIIB2 3     Pancreatic Endopeptidase E2
Protease E2 3     Proteinase E2
E12     EC 3.4.21.703
EL-12     Elastase-3B3
Cholesterol-Binding Pancreatic Protease2     EC 3.4.218
Chymotrypsin-Like Elastase Family Member 3B2     

External Ids:    HGNC: 159451   Entrez Gene: 234362   Ensembl: ENSG000002190737   UniProtKB: P088613   

Export aliases for CELA3B gene to outside databases

Previous GC identifers: GC01P022178 GC01P020547


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CELA3B:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six
elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other
elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from
the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a
digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B
may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have
been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used
as a measure of pancreatic function in clinical assays. (provided by RefSeq, May 2009)

UniProtKB/Swiss-Prot: CEL3B_HUMAN, P08861
Function: Efficient protease with alanine specificity but only little elastolytic activity

Gene Wiki entry for CELA3B


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CELA3B gene promoter:
         HOXA9B   HOXA9   Max1   NF-1   AP-4   Tal-1beta   Meis-1b   c-Ets-1   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELA3B promoter sequence
   Search SABiosciences Chromatin IP Primers for CELA3B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA3B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

CELA3B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELA3B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022303:  view genomic region     (about GC identifiers)

Start:
22,303,418 bp from pter      End:
22,325,135 bp from pter
Size:
21,718 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CEL3B_HUMAN, P08861 (See protein sequence)
Recommended Name: Chymotrypsin-like elastase family member 3B precursor  
Size: 270 amino acids; 29263 Da
Caution: Was originally (PubMed:2737288) thought to be elastase 1
Sequence caution: Sequence=CAH71872.1; Type=Erroneous gene model prediction; Sequence=CAH71873.1; Type=Erroneous gene
model prediction;
Secondary accessions: B2RE44 P11423 Q5VU28 Q5VU29 Q5VU30

Explore the universe of human proteins at neXtProt for CELA3B: NX_P08861

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P08861

  • 4/8 DME Specific Peptides for CELA3B (P08861) (see all 8)
     CYITGWG  GDSGGPL  DIALIKL  WPWQVSL 

    CELA3B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_031378.1  
    ENSEMBL proteins: 
     ENSP00000338369   ENSP00000363798   ENSP00000383135  

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    Uscn Proteins for CELA3B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS--


    CELA3B for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CELA3B for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P08861

    ProtoNet protein and cluster: P08861

    2 Blocks protein families:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CEL3B_HUMAN, P08861
    Similarity: Belongs to the peptidase S1 family. Elastase subfamily
    Similarity: Contains 1 peptidase S1 domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CEL3B_HUMAN, P08861
    Function: Efficient protease with alanine specificity but only little elastolytic activity
    Catalytic activity: Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin

    Enzyme Numbers (IUBMB): EC 3.4.21.701 EC 3.4.212

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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004252serine-type endopeptidase activity NAS2737288
    GO:0008233peptidase activity TAS2460440


    CELA3B for ontologies           About GeneDecksing



    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Protein digestion and absorption
    Protein digestion and absorption1.00
    2Pancreatic secretion
    Pancreatic secretion1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways



    2         Kegg Pathways  (Kegg details for CELA3B):
        Pancreatic secretion
    Protein digestion and absorption


    CELA3B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELA3B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for CELA3B (ENSP000003383694) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ASPMENSP000003563794STRING: ENSP00000356379
    CHRM3ENSP000002553804STRING: ENSP00000255380
    DMRTA2ENSP000003839094STRING: ENSP00000383909
    ECHDC2ENSP000003511254STRING: ENSP00000351125
    ELAVL4ENSP000003495944STRING: ENSP00000349594
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis NAS--
    GO:0008203cholesterol metabolic process TAS2826474


    CELA3B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for CELA3B:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

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    Search CenterWatch for drugs/clinical trials and news about CELA3B / CEL3B 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CELA3B gene: 
    NM_007352.2  

    Unigene Cluster for CELA3B:

    Chymotrypsin-like elastase family, member 3B
    Hs.728752  [show with all ESTs]
    Unigene Representative Sequence: AK308518
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000337107(uc001bfk.3) ENST00000374666 ENST00000400277 ENST00000473526


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    Additional cDNA sequence: 

    AK092382.1 AK308518.1 AK315798.1 BC005216.1 M16630.1 M18692.1 

    19 DOTS entries:

    DT.91757699  DT.454427  DT.91644562  DT.100796353  DT.100031236  DT.100796350  DT.95165839  DT.121444661 
    DT.121444682  DT.91757700  DT.95165860  DT.121444675  DT.121444692  DT.100737587  DT.100796356  DT.121444662 
    DT.91995108  DT.95165837  DT.95165849 

    24/497 AceView cDNA sequences (see all 497):

    BM128949 BM512399 AA844854 BM129835 AA367172 BM967226 BM352531 CA942316 
    BM126887 BM021454 BM129606 BM893889 BM967253 W40423 AA366614 BM893739 
    BE969836 BQ477793 AA366460 AA921359 BM511470 BU951503 BX497513 BC007028 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CELA3B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    CELA3B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    PancreasIslets of LangerhansMature Beta CellsPancreas
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CELA3B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CELA3B

    SOURCE GeneReport for Unigene cluster: Hs.728752

    UniProtKB/Swiss-Prot: CEL3B_HUMAN, P08861
    Tissue specificity: Pancreas. Not detectable in keratinocytes

        SABiosciences Expression via Pathway-Focused PCR Array including CELA3B: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CELA3B gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves LOC1008571161 proproteinase E-like 67.16(n)
    65.84(a)
      100857116  XM_003642539.1  XP_003642587.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    70(a)
    1 → many
    GL343980.1(93362-99260)
    African clawed frog
    (Xenopus laevis)
    Amphibia BX844895.12   -- 74.61(n)    BX844895.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Jon25Biii6
    Jon66Cii6
    (see all 31)
    Jonah 66Cii
    (see all 31)
    28(a)
    27(a)
    (see all 31)
    many ↔ many
    many ↔ many
    (see all 31)
    2L(4949941-4950763)
    3L(8385920-8386749)


    ENSEMBL Gene Tree for CELA3B (if available)
    TreeFam Gene Tree for CELA3B (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CELA3B gene
    CTRL2  CTRC2  CELA2A2  CELA12  CTRB12  CELA3A2  CELA2B2  CTRB22  
    18/91 SIMAP similar genes for CELA3B using alignment to 1 protein entry:     CEL3B_HUMAN(see all similar genes):
    ELA3A    CELA3A    CELA1    CELA2A    CTRC    ELA2A
    CELA2B    ELA2B    CTRB1    CTRB2    CTRL    DKFZp779M0222
    TMPRSS5    DF    OVCH1    CFD    GZMK    GZMM

    CELA3B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/582 NCBI SNPs in CELA3B are shown (see all 582    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120299941,2
    C,F,--22301419(+) GAGGGC/TAGGGG 1 -- us2k15Minor allele frequency- T:0.21NA EA 246
    rs285533341,2
    C--22301490(+) CACACA/GTTCCA 1 -- us2k10--------
    rs343137831,2
    C,--22301534(+) TTGGAG/-GGGGT 1 -- us2k11Minor allele frequency- -:0.50NA 2
    rs2010220531,2
    --22301539(+) GGGGG-/TTCACT 1 -- us2k10--------
    rs1840328671,2
    --22301617(+) GTCTGA/GCCGGG 1 -- us2k10--------
    rs49889191,2
    C,F,--22301622(+) GCCGGG/ATGCAG 1 -- us2k12Minor allele frequency- A:0.50NA 4
    rs716388081,2
    C,F,--22301635(+) GCTCAC/TGCCTG 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs49889221,2
    C,F,--22301701(+) GAAACC/TAGCCT 1 -- us2k12Minor allele frequency- T:0.50NA 4
    rs66717751,2
    C,--22301713(+) GCCAAC/TATGGT 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs49889231,2
    --22301727(+) accccA/Gtctct 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CELA3B (22303418 - 22325135 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 10 variations for CELA3B
         10 CNVs: 4216 29831 4215 74410 60805 3286 63254 2045 31612 84127

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CELA3B for disorders           About GeneDecksing

    19 diseases for CELA3B:    About MalaCards
    pancreatitis    cholesterol    maturity-onset diabetes of the young    maturity-onset diabetes of the young, type 3
    rift valley fever    exocrine pancreatic insufficiency    type 1 diabetes mellitus    actinobacillosis
    steatorrhea    pancreatic steatorrhea    pleuropneumonia    diabetes mellitus
    glanders    cystic fibrosis    nephropathy    diarrhea
    fibrosis    pancreatic cancer    bone fracture

    8 diseases from the University of Copenhagen DISEASES database for CELA3B:
    Exocrine pancreatic insufficiency     Pancreatitis     Steatorrhea     Pancreatic cancer
    Cystic fibrosis     Rift Valley fever     Actinobacillosis     Pancreatic steatorrhea

    Export disorders for CELA3B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CELA3B gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CELA3B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PubMed id 2826474)1, 2, 3 Tani T.... Takiguchi Y. (1988)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Localization and characterization of the glycosylation site of human pancreatic elastase 1. (PubMed id 2737288)1, 2 Wendorf P.... Linder D. (1989)
    6. Generation of a subunit III-like protein by autolysis of human and porcine proproteinase E in a binary complex with procarboxypeptidase A. (PubMed id 2675835)1, 2 Aviles F.X.... Puigserver A. (1989)
    7. Identification of a procarboxypeptidase A-truncated protease E binary complex in human pancreatic juice. (PubMed id 2753124)1, 2 Moulard M.... Chapus C. (1989)
    8. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. (PubMed id 2460440)1, 3 Shirasu Y....Ishida A. (1988)
    9. Characterization of two glycoproteins of human pancreatic juice: P35, a truncated protease E and P19, precursor of protein X. (PubMed id 3178837)1, 2 Guy-Crotte O.... Figarella C. (1988)
    10. Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA. (PubMed id 3477287)1, 2 Shen W.... Largman C. (1987)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23436 HGNC: 15945 AceView: ELA3AandELA3B Ensembl:ENSG00000219073 euGenes: HUgn23436
    ECgene: CELA3B Kegg: 23436 H-InvDB: CELA3B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CELA3B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CELA3B gene:
    Search GeneIP for patents involving CELA3B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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