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Aliases for CELA3B Gene

Aliases for CELA3B Gene

  • Chymotrypsin Like Elastase Family Member 3B 2 3 5
  • Cholesterol-Binding Pancreatic Protease 2 3
  • Pancreatic Endopeptidase E 2 3
  • Elastase 3B, Pancreatic 2 3
  • Elastase IIIB 3 4
  • Proteinase E 2 3
  • Elastase-3B 3 4
  • Protease E 3 4
  • ELA3B 3 4
  • Chymotrypsin-Like Elastase Family, Member 3B 2
  • Chymotrypsin-Like Elastase Family Member 3B 3
  • Pancreatic Elastase 1 3
  • Fecal Elastase 1 3
  • EC 3.4.21.70 4
  • Elastase 1 2
  • EC 3.4.21 58
  • CBPP 3

External Ids for CELA3B Gene

Previous HGNC Symbols for CELA3B Gene

  • ELA3B

Previous GeneCards Identifiers for CELA3B Gene

  • GC01P022178
  • GC01P022303
  • GC01P020547

Summaries for CELA3B Gene

Entrez Gene Summary for CELA3B Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009]

GeneCards Summary for CELA3B Gene

CELA3B (Chymotrypsin Like Elastase Family Member 3B) is a Protein Coding gene. Diseases associated with CELA3B include Actinobacillosis and Pleuropneumonia. Among its related pathways are Collagen chain trimerization and Pancreatic secretion. GO annotations related to this gene include serine-type endopeptidase activity and peptidase activity. An important paralog of this gene is CELA3A.

UniProtKB/Swiss-Prot for CELA3B Gene

  • Efficient protease with alanine specificity but only little elastolytic activity.

Gene Wiki entry for CELA3B Gene

Additional gene information for CELA3B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA3B Gene

Genomics for CELA3B Gene

Regulatory Elements for CELA3B Gene

Enhancers for CELA3B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H021918 2 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -47.2 -47177 22 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 SLC30A9 HSPG2 USP48 CELA3B GC01P021930 RPL21P29
GH01H021955 1.4 Ensembl ENCODE dbSUPER 6.5 -20.0 -20043 3 NFIB RARA GLIS2 FOS EGR2 SMARCA5 MXD4 REST GATAD2B ZEB2 USP48 NBPF3 CELA3B ENSG00000283234
GH01H021996 1.2 Ensembl ENCODE dbSUPER 6.6 +22.1 22059 5 FOXA2 JUN RARA SCRT2 ZNF239 NR2F6 CREM EGR2 GATAD2A SOX5 CDC42 LINC01635 CELA3B CELA3A GC01P021996
GH01H022140 0.5 FANTOM5 dbSUPER 7 +164.1 164088 0 CELA3A CELA3B LINC00339 GC01P022144 LOC105376845
GH01H021588 0.5 dbSUPER 5.6 -387.9 -387922 0 MCM3 ADNP ZNF600 HP1BP3 ZBTB40 LDLRAD2 HSPG2 DDOST LOC105376834 CELA3B RAP1GAP PIR35545
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CELA3B on UCSC Golden Path with GeneCards custom track

Genomic Location for CELA3B Gene

Chromosome:
1
Start:
21,976,925 bp from pter
End:
21,998,642 bp from pter
Size:
21,718 bases
Orientation:
Plus strand

Genomic View for CELA3B Gene

Genes around CELA3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CELA3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CELA3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA3B Gene

Proteins for CELA3B Gene

  • Protein details for CELA3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08861-CEL3B_HUMAN
    Recommended name:
    Chymotrypsin-like elastase family member 3B
    Protein Accession:
    P08861
    Secondary Accessions:
    • B2RE44
    • P11423
    • Q5VU28
    • Q5VU29
    • Q5VU30

    Protein attributes for CELA3B Gene

    Size:
    270 amino acids
    Molecular mass:
    29263 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAH71872.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH71873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CELA3B Gene

Selected DME Specific Peptides for CELA3B Gene

P08861:
  • CYITGWG
  • CNGDSGGP
  • GDSGGPL
  • DIALIKL
  • TGWGRLYTNGP
  • VHGVTSFVS
  • WWGSSVK
  • WPWQVSL

Post-translational modifications for CELA3B Gene

  • Glycosylation at posLast=114114
  • Modification sites at PhosphoSitePlus

Other Protein References for CELA3B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CELA3B Gene

Gene Families for CELA3B Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for CELA3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08861

UniProtKB/Swiss-Prot:

CEL3B_HUMAN :
  • Belongs to the peptidase S1 family. Elastase subfamily.
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA3B: view

Function for CELA3B Gene

Molecular function for CELA3B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin.
UniProtKB/Swiss-Prot Function:
Efficient protease with alanine specificity but only little elastolytic activity.

Enzyme Numbers (IUBMB) for CELA3B Gene

Gene Ontology (GO) - Molecular Function for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004252 serine-type endopeptidase activity NAS 2737288
GO:0008233 peptidase activity TAS 2460440
GO:0008236 serine-type peptidase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with CELA3B: view
genes like me logo Genes that share phenotypes with CELA3B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CELA3B

CRISPR Products

miRNA for CELA3B Gene

miRTarBase miRNAs that target CELA3B

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CELA3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CELA3B Gene

Localization for CELA3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CELA3B gene
Compartment Confidence
extracellular 5
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CELA3B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CELA3B Gene

Pathways & Interactions for CELA3B Gene

genes like me logo Genes that share pathways with CELA3B: view

Pathways by source for CELA3B Gene

2 KEGG pathways for CELA3B Gene

Gene Ontology (GO) - Biological Process for CELA3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0008203 cholesterol metabolic process TAS 2826474
genes like me logo Genes that share ontologies with CELA3B: view

No data available for SIGNOR curated interactions for CELA3B Gene

Drugs & Compounds for CELA3B Gene

(1) Drugs for CELA3B Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvelestat Investigational Pharma NE inhibitor 0

(1) ApexBio Compounds for CELA3B Gene

Compound Action Cas Number
Alvelestat NE inhibitor 848141-11-7
genes like me logo Genes that share compounds with CELA3B: view

Drug Products

Transcripts for CELA3B Gene

Unigene Clusters for CELA3B Gene

Chymotrypsin-like elastase family, member 3B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CELA3B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CELA3B Gene

No ASD Table

Relevant External Links for CELA3B Gene

GeneLoc Exon Structure for
CELA3B
ECgene alternative splicing isoforms for
CELA3B

Expression for CELA3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CELA3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA3B Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for CELA3B Gene

This gene is overexpressed in Pancreatic juice (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CELA3B Gene



Protein tissue co-expression partners for CELA3B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CELA3B Gene:

CELA3B

SOURCE GeneReport for Unigene cluster for CELA3B Gene:

Hs.728752

mRNA Expression by UniProt/SwissProt for CELA3B Gene:

P08861-CEL3B_HUMAN
Tissue specificity: Pancreas. Not detectable in keratinocytes.

Evidence on tissue expression from TISSUES for CELA3B Gene

  • Pancreas(5)
genes like me logo Genes that share expression patterns with CELA3B: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CELA3B Gene

Orthologs for CELA3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CELA3B 33
  • 99.01 (n)
dog
(Canis familiaris)
Mammalia CELA3B 33
  • 85.38 (n)
-- 34
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia CELA3B 33 34
  • 84.57 (n)
rat
(Rattus norvegicus)
Mammalia Cela3b 33
  • 83.52 (n)
mouse
(Mus musculus)
Mammalia Cela3b 33 16 34
  • 83.15 (n)
Gm13011 34
  • 73 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 78 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 40 (a)
ManyToMany
chicken
(Gallus gallus)
Aves LOC100857116 33
  • 67.16 (n)
-- 34
  • 67 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 72 (a)
ManyToMany
-- 34
  • 71 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494627 33
  • 67.19 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch73-44m9.5 34
  • 67 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
OneToMany
Species where no ortholog for CELA3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA3B Gene

ENSEMBL:
Gene Tree for CELA3B (if available)
TreeFam:
Gene Tree for CELA3B (if available)

Paralogs for CELA3B Gene

Variants for CELA3B Gene

Sequence variations from dbSNP and Humsavar for CELA3B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000509788 -- 21,977,652(+) TTTTC(C/T)CCATT intron-variant
rs1000637248 -- 21,982,931(+) CAGTC(C/T)GTTTT intron-variant
rs1001079154 -- 21,987,513(+) TCCCA(G/T)CTACT intron-variant
rs1001353295 -- 21,981,340(+) GAAGA(A/G)CCTTT intron-variant
rs1001533503 -- 21,987,193(+) GTCAT(A/G)CCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CELA3B Gene

Variant ID Type Subtype PubMed ID
dgv11e201 CNV deletion 23290073
dgv16e214 CNV loss 21293372
esv24116 CNV loss 19812545
esv2672264 CNV deletion 23128226
esv2745119 CNV deletion 23290073
esv2758927 CNV loss 17122850
esv2760299 CNV loss 21179565
esv2764236 CNV gain+loss 21179565
esv3556232 CNV deletion 23714750
esv3556344 CNV deletion 23714750
esv3585457 CNV loss 21293372
esv3585458 CNV gain 21293372
esv3892859 CNV loss 25118596
esv3892970 CNV loss 25118596
esv7729 CNV loss 19470904
nsv1160262 CNV deletion 26073780
nsv436921 CNV insertion 17901297
nsv469549 CNV loss 16826518
nsv470706 CNV loss 18288195
nsv834402 CNV loss 17160897
nsv834413 CNV loss 17160897
nsv945816 CNV duplication 23825009
nsv9657 CNV loss 18304495

Variation tolerance for CELA3B Gene

Residual Variation Intolerance Score: 97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.24; 70.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CELA3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CELA3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA3B Gene

Disorders for CELA3B Gene

MalaCards: The human disease database

(6) MalaCards diseases for CELA3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
actinobacillosis
  • actinobacillosis, nos
pleuropneumonia
pancreas disease
  • abnormality of the pancreas
retinitis pigmentosa 19
  • rp19
holoprosencephaly 1
  • hpe1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CELA3B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CELA3B
genes like me logo Genes that share disorders with CELA3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CELA3B Gene

Publications for CELA3B Gene

  1. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PMID: 2826474) Tani T … Takiguchi Y (The Journal of biological chemistry 1988) 2 3 4 60
  2. Identification of pancreatic juice proteins as biomarkers of pancreatic cancer. (PMID: 20428826) Gao J … Ma L (Oncology reports 2010) 3 22 60
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for CELA3B Gene

Sources for CELA3B Gene

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