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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CELA3A Gene

protein-coding   GIFtS: 53
GCID: GC01P022328

Chymotrypsin-Like Elastase Family, Member 3A

(Previous names: elastase 3A, pancreatic (protease E), elastase 3A, pancreatic)
(Previous symbol: ELA3A)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chymotrypsin-Like Elastase Family, Member 3A1 2     Chymotrypsin-Like Elastase Family Member 3A2
ELA3A1 2 3     Elastase 12
Protease E1 2 3     elastase-3A2
Elastase 3A, Pancreatic1 2     EC 3.4.21.703
Elastase IIIA2 3     Elastase-3A3
ELA32 3     EC 3.4.218
Elastase 3A, Pancreatic (Protease E)1     

External Ids:    HGNC: 159441   Entrez Gene: 101362   Ensembl: ENSG000001427897   UniProtKB: P090933   

Export aliases for CELA3A gene to outside databases

Previous GC identifers: GC01P022201 GC01P020572


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CELA3A Gene:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have
six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other
elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted
from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it
has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues.
Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and
elastase 3B have been referred to as protease E and as elastase 1. (provided by RefSeq, Jul 2008)

GeneCards Summary for CELA3A Gene: 
CELA3A (chymotrypsin-like elastase family, member 3A) is a protein-coding gene. Diseases associated with CELA3A include pancreatitis. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRL.

UniProtKB/Swiss-Prot: CEL3A_HUMAN, P09093
Function: Efficient protease with alanine specificity but only little elastolytic activity

Gene Wiki entry for CELA3A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CELA3A gene promoter:
         HOXA9B   HOXA9   HEN1   AP-4   Meis-1b   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELA3A promoter sequence
   Search SABiosciences Chromatin IP Primers for CELA3A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA3A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.12   Ensembl cytogenetic band:  1p36.12   HGNC cytogenetic band: 1p36.12

CELA3A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELA3A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P022328:  view genomic region     (about GC identifiers)

Start:
22,328,149 bp from pter      End:
22,339,035 bp from pter
Size:
10,887 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEL3A_HUMAN, P09093 (See protein sequence)
Recommended Name: Chymotrypsin-like elastase family member 3A precursor  
Size: 270 amino acids; 29489 Da
Secondary accessions: B1AQ53 Q9BRW4

Explore the universe of human proteins at neXtProt for CELA3A: NX_P09093

Explore proteomics data for CELA3A at MOPED 

4/7 DME Specific Peptides for CELA3A (P09093) (see all 7)
 CYITGWG  GDSGGPL  DIALIKL  WPWQVSL 

CELA3A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CELA3A Protein Expression
REFSEQ proteins: NP_005738.4  
ENSEMBL proteins: 
 ENSP00000290122   ENSP00000363795   ENSP00000383130  

Human Recombinant Protein Products for CELA3A: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P09093

ProtoNet protein and cluster: P09093

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CEL3A_HUMAN, P09093
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


CELA3A for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CEL3A_HUMAN, P09093
Function: Efficient protease with alanine specificity but only little elastolytic activity
Catalytic activity: Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin

     Enzyme Numbers (IUBMB): EC 3.4.21.701 EC 3.4.212

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
     
CELA3A for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CELA3A:
 Decreased viability of wild-ty  Increased G1 DNA content 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CELA3A 
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miRNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for CELA3A About                                                                                                See pathways by source

SuperPathContained pathways About
1Protein digestion and absorption
Protein digestion and absorption
2Pancreatic secretion
Pancreatic secretion

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2         Kegg Pathways  (Kegg details for CELA3A):
    Pancreatic secretion
Protein digestion and absorption


CELA3A for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELA3A

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/28 Interacting proteins for CELA3A (P090933 ENSP000002901224) via UniProtKB, MINT, STRING, and/or I2D (see all 28)
InteractantInteraction Details
GeneCardExternal ID(s)
CREB3O438893I2D: score=1 
TFPIENSP000002331564STRING: ENSP00000233156
ADAMTSL4-AS1ENSP000003580314STRING: ENSP00000358031
ATPIF1ENSP000003352034STRING: ENSP00000335203
C1orf105ENSP000003567004STRING: ENSP00000356700
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis IEA--
GO:0007586digestion TAS2826474
GO:0008203cholesterol metabolic process TAS2826474

CELA3A for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for CELA3A:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CELA3A (CEL3A)

Search CenterWatch for drugs/clinical trials and news about CELA3A / CEL3A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CELA3A gene: 
NM_005747.4  

Unigene Cluster for CELA3A:

Chymotrypsin-like elastase family, member 3A
Hs.181289  [show with all ESTs]
Unigene Representative Sequence: AK308514
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000290122(uc001bfl.3) ENST00000374663(uc009vqf.3) ENST00000400271

miRNA
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Clone
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                     Customized lentivirus expression plasmids for stable overexpression of CELA3A 
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA3A
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA3A

Additional mRNA sequence: 

AK225620.1 AK308510.1 AK308514.1 AK308518.1 BC005918.1 BC007028.1 BC008383.1 BC015103.1 
D00306.1 

18 DOTS entries:

DT.100796350  DT.454427  DT.91757699  DT.100796353  DT.121444662  DT.121444687  DT.121444701  DT.95165838 
DT.100737587  DT.100796351  DT.100796356  DT.121444661  DT.121444682  DT.91644562  DT.91757700  DT.95165837 
DT.95165839  DT.95165849 

24/497 AceView cDNA sequences (see all 497):

BM893739 AA367172 AA366614 BM021454 BM967226 W40423 BM352531 BM967253 
BM126887 CA942316 BM512399 AA844854 BM128949 BM129835 BM893889 BM129606 
BM509798 AA835281 AA363465 AA845162 BM876330 BM129235 AA366054 CA867023 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CELA3A    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:                                          
SP2:              -     -                     


ECgene alternative splicing isoforms for CELA3A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CELA3A expression in normal human tissues (normalized intensities)      CELA3A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTGTGTGCTG
CELA3A Expression
About this image


CELA3A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/3 selected tissues (see all 3) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 2 entries
         Duct Cells Pancreatic Ducts
         Pancreatic Islet   
 
 Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
         neonatal small intestine   
 
 Eye (Sensory Organs)
         retinal amacrine cell p0   

See CELA3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CELA3A

SOURCE GeneReport for Unigene cluster: Hs.181289
    SABiosciences Expression via Pathway-Focused PCR Array including CELA3A: 
          Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA3A
In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CELA3A gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm130111 , 5 predicted gene 130111, 5 79.06(n)1
76.21(a)1
  4 (69.88 cM)5
2427111  NM_001126318.11  NP_001119790.11 
 1374015545 
chicken
(Gallus gallus)
Aves --
--
64(a)
1 → many
21(6521864-6524784)
lizard
(Anolis carolinensis)
Reptilia --
--
--
68(a)
67(a)
many ↔ many
many ↔ many
GL343980.1(88963-101607)
GL343980.1(73990-80259)


ENSEMBL Gene Tree for CELA3A (if available)
TreeFam Gene Tree for CELA3A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CELA3A gene
CTRL2  CTRC2  CELA2A2  CELA3B2  CELA12  CTRB12  CELA2B2  OVCH22  
CTRB22  OVCH12  
18/98 SIMAP similar genes for CELA3A using alignment to 4 protein entries:     CEL3A_HUMAN (see all proteins) (see all similar genes):
ELA3A    CELA3B    CELA1    CELA2A    ELA2A    CELA2B
ELA2B    CTRC    KLK15    PRSS47    TMPRSS3    DKFZp779M0222
PRSS8    CTRL    KLK5    PRSS21    TPSB2    CTRB1

CELA3A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/546 SNPs in CELA3A are shown (see all 546)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1874926201,2
--22326225(+) CTAACC/TCTATC 1 -- us2k10--------
rs1383000411,2
--22326248(+) CCTCCC/TGGGCC 1 -- us2k10--------
rs1928663181,2
--22326274(+) CCTGGC/TGTAGG 1 -- us2k10--------
rs1151458481,2
C,F--22326324(+) TGTCCG/AGGCAC 1 -- us2k11Minor allele frequency- A:0.05NA 120
rs1443194991,2
--22326327(+) CCGGGC/TACATA 1 -- us2k10--------
rs1181527001,2
F--22326328(+) CGGGCA/GCATAG 1 -- us2k11Minor allele frequency- G:0.06EA 120
rs1140919881,2
F--22326401(+) CTTCCA/C/TTTGTG 1 -- us2k11NA 120
rs1164224371,2
C,F--22326416(+) CACACG/ATTCCA 1 -- us2k12Minor allele frequency- A:0.20NA EA 240
rs1160523191,2
C,F--22326422(+) TTCCAC/TGAACC 1 -- us2k12Minor allele frequency- T:0.18WA NA 238
rs1487492621,2
C--22326455(+) TGTGAC/TTGGAG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CELA3A (22328149 - 22339035 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/13 variations for CELA3A (see all 13):    About this table     
Variant IDTypeSubtypePubMed ID
dgv21e201CNV Deletion23290073
esv2422105CNV Deletion20811451
esv2672264CNV Deletion23128226
nsv9657CNV Loss18304495
esv7729CNV Loss19470904
dgv27n67CNV Loss20364138
nsv470706CNV Loss18288195
nsv469549CNV Loss16826518
nsv834413CNV Loss17160897
esv24116CNV Loss19812545

SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CELA3A
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for CELA3A:    About MalaCards
pancreatitis    


CELA3A for disorders           About GeneDecksing


Export disorders for CELA3A gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CELA3A gene integrated from 9 sources:
(articles sorted by number of sources associating them with CELA3A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. (PubMed id 2460440)1, 2, 3 Shirasu Y....Ishida A. (1988)
  2. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PubMed id 2826474)1, 2, 3 Tani T.... Takiguchi Y. (1988)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
  5. Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells. (PubMed id 12373299)1 Shimada S....Ogawa M. (2002)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
  8. Evaluation of the extracellular proteins in full-scal e activated sludges. (PubMed id 18653206)9 Park C....Esen A. (2008)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 10136 HGNC: 15944 AceView: ELA3AandELA3B Ensembl:ENSG00000142789 euGenes: HUgn10136
ECgene: CELA3A Kegg: 10136 H-InvDB: CELA3A

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CELA3A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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Patent Information for CELA3A gene:
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