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Aliases for CELA3A Gene

Aliases for CELA3A Gene

  • Chymotrypsin Like Elastase Family Member 3A 2 3 5
  • Protease E 2 3 4
  • Chymotrypsin-Like Elastase Family, Member 3A 2 3
  • Elastase 3A, Pancreatic 2 3
  • Elastase IIIA 3 4
  • Elastase-3A 3 4
  • ELA3A 3 4
  • ELA3 3 4
  • Elastase 3A, Pancreatic (Protease E) 2
  • EC 4
  • Elastase 1 3
  • EC 3.4.21 63

External Ids for CELA3A Gene

Previous HGNC Symbols for CELA3A Gene

  • ELA3A

Previous GeneCards Identifiers for CELA3A Gene

  • GC01P022201
  • GC01P022328
  • GC01P020572

Summaries for CELA3A Gene

Entrez Gene Summary for CELA3A Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CELA3A Gene

CELA3A (Chymotrypsin Like Elastase Family Member 3A) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

UniProtKB/Swiss-Prot for CELA3A Gene

  • Efficient protease with alanine specificity but only little elastolytic activity.

Gene Wiki entry for CELA3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA3A Gene

Genomics for CELA3A Gene

Regulatory Elements for CELA3A Gene

Enhancers for CELA3A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CELA3A on UCSC Golden Path with GeneCards custom track

Genomic Location for CELA3A Gene

22,001,656 bp from pter
22,012,542 bp from pter
10,887 bases
Plus strand

Genomic View for CELA3A Gene

Genes around CELA3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CELA3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CELA3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA3A Gene

Proteins for CELA3A Gene

  • Protein details for CELA3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsin-like elastase family member 3A
    Protein Accession:
    Secondary Accessions:
    • B1AQ53
    • Q9BRW4

    Protein attributes for CELA3A Gene

    270 amino acids
    Molecular mass:
    29489 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CELA3A Gene

Proteomics data for CELA3A Gene at MOPED

Selected DME Specific Peptides for CELA3A Gene

Post-translational modifications for CELA3A Gene

Other Protein References for CELA3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains & Families for CELA3A Gene

Suggested Antigen Peptide Sequences for CELA3A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA3A: view

No data available for Gene Families for CELA3A Gene

Function for CELA3A Gene

Molecular function for CELA3A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin.
UniProtKB/Swiss-Prot Function:
Efficient protease with alanine specificity but only little elastolytic activity.

Enzyme Numbers (IUBMB) for CELA3A Gene

genes like me logo Genes that share phenotypes with CELA3A: view

Animal Model Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CELA3A Gene

Localization for CELA3A Gene

Subcellular locations from

Jensen Localization Image for CELA3A Gene COMPARTMENTS Subcellular localization image for CELA3A gene
Compartment Confidence
extracellular 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CELA3A Gene

Pathways & Interactions for CELA3A Gene

genes like me logo Genes that share pathways with CELA3A: view

Pathways by source for CELA3A Gene

2 KEGG pathways for CELA3A Gene

Interacting Proteins for CELA3A Gene

Gene Ontology (GO) - Biological Process for CELA3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007586 digestion TAS 2826474
genes like me logo Genes that share ontologies with CELA3A: view

No data available for SIGNOR curated interactions for CELA3A Gene

Drugs & Compounds for CELA3A Gene

(1) Drugs for CELA3A Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Alvelestat Pharma NE inhibitor 0

(1) ApexBio Compounds for CELA3A Gene

Compound Action Cas Number
Alvelestat NE inhibitor 848141-11-7
genes like me logo Genes that share compounds with CELA3A: view

Transcripts for CELA3A Gene

mRNA/cDNA for CELA3A Gene

Unigene Clusters for CELA3A Gene

Chymotrypsin-like elastase family, member 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CELA3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: - -

Relevant External Links for CELA3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CELA3A Gene

mRNA expression in normal human tissues for CELA3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA3A Gene

This gene is overexpressed in Pancreas (x52.8).

Protein differential expression in normal tissues from HIPED for CELA3A Gene

This gene is overexpressed in Pancreatic juice (64.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CELA3A Gene

SOURCE GeneReport for Unigene cluster for CELA3A Gene Hs.181289

genes like me logo Genes that share expression patterns with CELA3A: view

Protein tissue co-expression partners for CELA3A Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CELA3A Gene

Orthologs for CELA3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA3A Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Gm13011 35
  • 79.06 (n)
  • 76.21 (a)
Cela3a 16
Cela3b 36
  • 80 (a)
Gm13011 36
  • 72 (a)
(Pan troglodytes)
Mammalia CELA3A 35
  • 97.78 (n)
  • 95.56 (a)
  • 97 (a)
(Bos Taurus)
Mammalia CELA3B 36
  • 81 (a)
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
(Gallus gallus)
Aves -- 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
-- 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ela3b 35
  • 67.45 (n)
  • 64.57 (a)
(Danio rerio)
Actinopterygii si:ch73-44m9.5 36
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for CELA3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA3A Gene

Gene Tree for CELA3A (if available)
Gene Tree for CELA3A (if available)

Paralogs for CELA3A Gene

Paralogs for CELA3A Gene

genes like me logo Genes that share paralogs with CELA3A: view

Variants for CELA3A Gene

Sequence variations from dbSNP and Humsavar for CELA3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs3820285 - 22,009,784(-) CAAAG(C/G)CAGAA reference, missense
rs7531336 - 22,003,030(+) CTCTC(A/G)CTCTT reference, missense
rs7533776 - 22,003,032(+) CTCAC(C/T)CTTCC reference, missense
rs7519660 - 22,003,050(+) TTGTC(A/C)ATGGT reference, missense
rs9187 -- 22,009,812(+) AAGCC(C/T)ACGGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CELA3A Gene

Variant ID Type Subtype PubMed ID
nsv469549 CNV Loss 16826518
nsv470706 CNV Loss 18288195
dgv43e1 CNV Complex 17122850
nsv834413 CNV Loss 17160897
esv24116 CNV Loss 19812545
esv2672264 CNV Deletion 23128226
dgv21e201 CNV Deletion 23290073
esv7729 CNV Loss 19470904
nsv9657 CNV Loss 18304495
dgv27n67 CNV Loss 20364138
nsv441686 CNV CNV 18776908
esv2422105 CNV Deletion 20811451
nsv528664 CNV Gain 19592680

Variation tolerance for CELA3A Gene

Residual Variation Intolerance Score: 91.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.05; 75.19% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CELA3A Gene

Disorders for CELA3A Gene

Relevant External Links for CELA3A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CELA3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CELA3A Gene

Publications for CELA3A Gene

  1. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. (PMID: 2460440) Shirasu Y. … Ogawa M. (J. Biochem. 1988) 2 3 4 67
  2. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PMID: 2826474) Tani T. … Takiguchi Y. (J. Biol. Chem. 1988) 2 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Evaluation of the extracellular proteins in full-scale activated sludges. (PMID: 18653206) Park C. … Esen A. (Water Res. 2008) 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for CELA3A Gene

Sources for CELA3A Gene