CELA3A Gene
protein-coding GIFtS: 51
GCID: GC01P022328
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chymotrypsin-like elastase family, member 3A(Previous names: elastase 3A, pancreatic (protease E), elastase 3A, pancreatic...)
(Previous symbol: ELA3A)
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Aliases
for CELA3A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chymotrypsin-Like Elastase Family, Member 3A1 2 | | Chymotrypsin-Like Elastase Family Member 3A2 | | ELA31 2 3 | | Elastase 12 | | ELA3A1 2 3 | | Elastase-3A3 | | Elastase 3A, Pancreatic1 2 | | EC 3.4.21.703 | | Elastase IIIA2 3 | | Elastase-3A3 | | Protease E2 3 | | EC 3.4.218 | | Elastase 3A, Pancreatic (Protease E)1 | | |
Export aliases for CELA3A gene to outside databasesPrevious GC identifers: GC01P022201 GC01P020572 |
Summaries
for CELA3A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CELA3A:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have sixelastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike otherelastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted fromthe pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has adigestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3Amay also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B havebeen referred to as protease E and as elastase 1. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CEL3A_HUMAN, P09093Function: Efficient protease with alanine specificity but only little elastolytic activity
Gene Wiki entry for CELA3A
|
Genomic Views
for CELA3A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CELA3A gene promoter:
HOXA9B HOXA9 HEN1 AP-4 Meis-1b Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for CELA3A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA3A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.12 Ensembl cytogenetic band: 1p36.12 HGNC cytogenetic band: 1p36.12CELA3A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P022328: view genomic region
(about GC identifiers)
Start:
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22,328,149 bp from pter |
End:
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22,339,035 bp from pter |
Size:
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10,887 bases |
Orientation:
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plus strand |
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Proteins
for CELA3A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEL3A_HUMAN, P09093 (See
protein sequence)Recommended Name: Chymotrypsin-like elastase family member 3A precursor Size: 270 amino acids; 29489 Da
Secondary accessions: B1AQ53 Q9BRW4Explore the universe of human proteins at neXtProt for CELA3A: NX_P09093
4/7 DME Specific Peptides for CELA3A (P09093) (see all 7)
CELA3A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005738.4
ENSEMBL proteins: ENSP00000290122 ENSP00000363795 ENSP00000363793 ENSP00000383130
Human Recombinant Protein Products for CELA3A:
CELA3A Antibody Products:
Assay Products for CELA3A: |
Protein
Domains /
Families
for CELA3A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CELA3A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P09093ProtoNet protein and cluster: P09093 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: CEL3A_HUMAN, P09093Similarity: Belongs to the peptidase S1 family. Elastase subfamilySimilarity: Contains 1 peptidase S1 domain |
Function
for CELA3A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: CEL3A_HUMAN, P09093Function: Efficient protease with alanine specificity but only little elastolytic activityCatalytic activity: Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin Enzyme Numbers (IUBMB): EC 3.4.21.701 EC 3.4.212
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
CELA3A for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for CELA3A:
Animal Models:
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELA3A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CELA3A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA3A |
|
Pathways & Interactions
for CELA3A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
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Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein digestion and absorption | | | 2 | Pancreatic secretion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for CELA3A):
CELA3A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELA3A
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/28 Interacting proteins for CELA3A (P090933 ENSP000002901224) via UniProtKB, MINT, STRING, and/or I2D (see all 28)About this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CELA3A for ontologies About GeneDecksing
|
Drugs & Compounds
for CELA3A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CELA3A
Search CenterWatch for drugs/clinical trials and news about CELA3A / CEL3A
|
Transcripts
for CELA3A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CELA3A gene: NM_005747.4 Unigene Cluster for CELA3A: Chymotrypsin-like elastase family, member 3A Hs.181289 [show with all ESTs]Unigene Representative Sequence: AK3085144 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000290122(uc001bfl.3) ENST00000374663(uc009vqf.3) ENST00000374661
ENST00000400271
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELA3A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELA3A
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CELA3A (NM_005747) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CELA3A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA3A |
Additional cDNA sequence: AK225620.1 AK308510.1 AK308514.1 BC005918.1 BC007028.1 BC008383.1 BC015103.1 D00306.1 17 DOTS entries: DT.100796350 DT.454427 DT.91757699 DT.100796353 DT.121444662 DT.121444687 DT.121444701 DT.95165838 DT.100737587 DT.100796351 DT.100796356 DT.121444661 DT.121444682 DT.91757700 DT.95165837 DT.95165839 DT.95165849 24/497 AceView cDNA sequences (see all 497): BM967226 BM129835 AA367172 BM128949 AA844854 BM512399 BM893739 AA366614 W40423 BM967253 BM893889 BM129606 BM021454 CA942316 BM126887 BM352531 BQ631095 BX498781 BC005918 BQ631917 BX497426 BM310730 NM_005747 AA845170
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CELA3A About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for CELA3A
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Expression
for CELA3A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CELA3A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTGTGTGCTG
About this image
See CELA3A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CELA3A
SOURCE GeneReport for Unigene cluster: Hs.181289
SABiosciences Expression via Pathway-Focused PCR Array including CELA3A: | Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CELA3A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CELA3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA3A |
Orthologs
for CELA3A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CELA3A gene from 2/12 species (see all 12) About this table
ENSEMBL Gene Tree for CELA3A (if available)
TreeFam Gene Tree for CELA3A (if available) |
Paralogs
for CELA3A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CELA3A gene
- CTRL2 CTRC2 CELA2A2 CELA3B2 CELA12 CTRB12 CELA2B2 CTRB22
18/103 SIMAP similar genes for CELA3A using alignment to 4 protein entries: CEL3A_HUMAN (see all proteins)
(see all similar genes):ELA3A CELA3B CELA1 CELA2A ELA2A CELA2B
ELA2B CTRC PRSS47 TMPRSS3 DKFZp779M0222 PRSS8
KLK15 CTRL PRSS21 TPSB2 TPSAB1 CTRB1
CELA3A for paralogs About GeneDecksing
|
Genomic Variants
for CELA3A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CELA3A (22328149 - 22339035 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for CELA3A
10 CNVs: 4216 29831 74410 60805 3286 63254 38172 2045 31612 84127 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CELA3A |
|
Disorders
/ Diseases
for CELA3A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CELA3A for disorders About GeneDecksing
4  diseases for CELA3A: About MalaCardspancreatitis cholesterol pancreatic carcinoma carcinoma
Export disorders for CELA3A gene to outside databases
|
Publications
for CELA3A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CELA3A gene integrated from 9 sources:
(articles sorted by number of sources associating them with CELA3A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. (PubMed id 2460440)1, 2, 3 Shirasu Y....Ishida A. (1988)
- Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PubMed id 2826474)1, 2, 3 Tani T.... Takiguchi Y. (1988)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Pancreatic elastase IIIA and its variants are expressed in pancreatic carcinoma cells. (PubMed id 12373299)1 Shimada S....Ogawa M. (2002)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)
- Evaluation of the extracellular proteins in full-scal e activated sludges. (PubMed id 18653206)9 Park C....Esen A. (2008)
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External Searches for CELA3A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CELA3A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CELA3A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CELA3A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CELA3A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CELA3A gene:
Search GeneIP for patents involving CELA3A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CELA3A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CELA3A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CELA3A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA3A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELA3A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA3A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA3A |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA3A |
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