Aliases for CELA3A Gene
External Ids for CELA3A Gene
Previous HGNC Symbols for CELA3A Gene
Previous GeneCards Identifiers for CELA3A Gene
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]
GeneCards Summary for CELA3A Gene
CELA3A (Chymotrypsin Like Elastase Family Member 3A) is a Protein Coding gene. Among its related pathways are Protein digestion and absorption and Pancreatic secretion. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA3B.
UniProtKB/Swiss-Prot for CELA3A Gene
Efficient protease with alanine specificity but only little elastolytic activity.