Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CELA3A Gene

Aliases for CELA3A Gene

  • Chymotrypsin-Like Elastase Family, Member 3A 2 3
  • Protease E 2 3 4
  • Elastase 3A, Pancreatic 2 3
  • Elastase IIIA 3 4
  • Elastase-3A 3 4
  • ELA3A 3 4
  • ELA3 3 4
  • Chymotrypsin-Like Elastase Family Member 3A 3
  • Elastase 3A, Pancreatic (Protease E) 2
  • EC 4
  • Elastase 1 3
  • EC 3.4.21 63

External Ids for CELA3A Gene

Previous HGNC Symbols for CELA3A Gene

  • ELA3A

Previous GeneCards Identifiers for CELA3A Gene

  • GC01P022201
  • GC01P022328
  • GC01P020572

Summaries for CELA3A Gene

Entrez Gene Summary for CELA3A Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3A has little elastolytic activity. Like most of the human elastases, elastase 3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3A preferentially cleaves proteins after alanine residues. Elastase 3A may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1. [provided by RefSeq, Jul 2008]

GeneCards Summary for CELA3A Gene

CELA3A (Chymotrypsin-Like Elastase Family, Member 3A) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

UniProtKB/Swiss-Prot for CELA3A Gene

  • Efficient protease with alanine specificity but only little elastolytic activity

Gene Wiki entry for CELA3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA3A Gene

Genomics for CELA3A Gene

Regulatory Elements for CELA3A Gene

Genomic Location for CELA3A Gene

22,001,656 bp from pter
22,012,542 bp from pter
10,887 bases
Plus strand

Genomic View for CELA3A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELA3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA3A Gene

Proteins for CELA3A Gene

  • Protein details for CELA3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsin-like elastase family member 3A
    Protein Accession:
    Secondary Accessions:
    • B1AQ53
    • Q9BRW4

    Protein attributes for CELA3A Gene

    270 amino acids
    Molecular mass:
    29489 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CELA3A Gene

Proteomics data for CELA3A Gene at MOPED

Selected DME Specific Peptides for CELA3A Gene

Post-translational modifications for CELA3A Gene

Other Protein References for CELA3A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CELA3A Gene

Suggested Antigen Peptide Sequences for CELA3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P09093
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA3A: view

No data available for Gene Families for CELA3A Gene

Function for CELA3A Gene

Molecular function for CELA3A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Ala- -Xaa. Does not hydrolyze elastin
UniProtKB/Swiss-Prot Function: Efficient protease with alanine specificity but only little elastolytic activity

Enzyme Numbers (IUBMB) for CELA3A Gene

Gene Ontology (GO) - Molecular Function for CELA3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with CELA3A: view

Phenotypes for CELA3A Gene

genes like me logo Genes that share phenotypes with CELA3A: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CELA3A Gene

Localization for CELA3A Gene

Subcellular locations from

Jensen Localization Image for CELA3A Gene COMPARTMENTS Subcellular localization image for CELA3A gene
Compartment Confidence
extracellular 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CELA3A Gene

Pathways for CELA3A Gene

genes like me logo Genes that share pathways with CELA3A: view

Pathways by source for CELA3A Gene

2 KEGG pathways for CELA3A Gene

Interacting Proteins for CELA3A Gene

Gene Ontology (GO) - Biological Process for CELA3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007586 digestion TAS 2826474
GO:0008203 cholesterol metabolic process TAS 2826474
genes like me logo Genes that share ontologies with CELA3A: view

Transcripts for CELA3A Gene

mRNA/cDNA for CELA3A Gene

Unigene Clusters for CELA3A Gene

Chymotrypsin-like elastase family, member 3A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CELA3A Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP2: - -

Relevant External Links for CELA3A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CELA3A Gene

mRNA expression in normal human tissues for CELA3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA3A Gene

This gene is overexpressed in Pancreas (52.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CELA3A Gene

SOURCE GeneReport for Unigene cluster for CELA3A Gene Hs.181289

genes like me logo Genes that share expressions with CELA3A: view

No data available for mRNA Expression by UniProt/SwissProt for CELA3A Gene

Orthologs for CELA3A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA3A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CELA3A 35
  • 97.78 (n)
  • 95.56 (a)
  • 97 (a)
(Bos Taurus)
Mammalia CELA3B 36
  • 81 (a)
(Canis familiaris)
Mammalia -- 36
  • 82 (a)
(Mus musculus)
Mammalia Cela3b 36
  • 80 (a)
Gm13011 35
  • 79.06 (n)
  • 76.21 (a)
Gm13011 16
Gm13011 36
  • 72 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 55 (a)
(Gallus gallus)
Aves -- 36
  • 64 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 67 (a)
-- 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ela3b 35
  • 67.45 (n)
  • 64.57 (a)
(Danio rerio)
Actinopterygii si:ch73-44m9.5 36
  • 65 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for CELA3A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA3A Gene

Gene Tree for CELA3A (if available)
Gene Tree for CELA3A (if available)

Paralogs for CELA3A Gene

Paralogs for CELA3A Gene

genes like me logo Genes that share paralogs with CELA3A: view

Variants for CELA3A Gene

Sequence variations from dbSNP and Humsavar for CELA3A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs9187 -- 22,009,812(+) AAGCC(C/T)ACGGT reference, synonymous-codon
rs12908 -- 22,009,815(+) CCCAC(A/G)GTGTT synonymous-codon, reference
rs2473313 -- 22,012,860(-) GCAGA(G/T)TTTTA downstream-variant-500B
rs3806297 -- 22,009,878(-) CCTCC(A/G/T)GGCCG intron-variant
rs3820285 - 22,009,784(-) CAAAG(C/G)CAGAA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CELA3A Gene

Variant ID Type Subtype PubMed ID
nsv469549 CNV Loss 16826518
nsv470706 CNV Loss 18288195
dgv43e1 CNV Complex 17122850
nsv834413 CNV Loss 17160897
esv24116 CNV Loss 19812545
esv2672264 CNV Deletion 23128226
dgv21e201 CNV Deletion 23290073
esv7729 CNV Loss 19470904
nsv9657 CNV Loss 18304495
dgv27n67 CNV Loss 20364138
nsv441686 CNV CNV 18776908
esv2422105 CNV Deletion 20811451
nsv528664 CNV Gain 19592680

Relevant External Links for CELA3A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA3A Gene

Disorders for CELA3A Gene

No disorders were found for CELA3A Gene.

No data available for UniProtKB/Swiss-Prot for CELA3A Gene

Publications for CELA3A Gene

  1. Molecular cloning of complementary DNA encoding one of the human pancreatic protease E isozymes. (PMID: 2460440) Shirasu Y. … Ogawa M. (J. Biochem. 1988) 2 3 4
  2. Identification of a novel class of elastase isozyme, human pancreatic elastase III, by cDNA and genomic gene cloning. (PMID: 2826474) Tani T. … Takiguchi Y. (J. Biol. Chem. 1988) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 4
  5. Evaluation of the extracellular proteins in full-scale activated sludges. (PMID: 18653206) Park C. … Esen A. (Water Res. 2008) 23

Products for CELA3A Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CELA3A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CELA3A
    • Block miRNA regulation of CELA3A using miScript Target Protectors

    Sources for CELA3A Gene

    Back to Top