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CELA2B Gene

protein-coding   GIFtS: 50
GCID: GC01P015792

Chymotrypsin-Like Elastase Family, Member 2B

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chymotrypsin-Like Elastase Family, Member 2B1 2     Elastase 2B2
ELA2B2 3 5     elastase-2B2
EC 3.4.21.713 8     Pancreatic Elastase IIB (ELA2B)2
Pancreatic Elastase IIB1     Elastase-2B3
RP11-265F14.22     EC 3.4.218
Chymotrypsin-Like Elastase Family Member 2B2     

External Ids:    HGNC: 299951   Entrez Gene: 510322   Ensembl: ENSG000002157047   OMIM: 6094445   UniProtKB: P082183   

Export aliases for CELA2B gene to outside databases

Previous GC identifers: GC01P015677 GC01P014326


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CELA2B Gene:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have
six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of
the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has
been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. (provided by
RefSeq, Jul 2008)

GeneCards Summary for CELA2B Gene:
CELA2B (chymotrypsin-like elastase family, member 2B) is a protein-coding gene. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRL.

UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218
Function: Acts upon elastin

Gene Wiki entry for CELA2B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Search for regulatory transcription factor binding sites for CELA2B
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELA2B promoter sequence
   Search Chromatin IP Primers for CELA2B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CELA2B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

CELA2B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELA2B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P015792:  view genomic region     (about GC identifiers)

Start:
15,792,404 bp from pter      End:
15,817,895 bp from pter
Size:
25,492 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218 (See protein sequence)
Recommended Name: Chymotrypsin-like elastase family member 2B precursor  
Size: 269 amino acids; 28810 Da
Secondary accessions: Q14D16 Q6ISM5 Q96QV5

Explore the universe of human proteins at neXtProt for CELA2B: NX_P08218

Explore proteomics data for CELA2B at MOPED

Selected DME Specific Peptides for CELA2B (P08218) (see all 8)
 GDSGGPL  WPWQVSL  VLTAAHC  WVLTAAH 


See CELA2B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_056933.2  
ENSEMBL proteins: 
 ENSP00000365075   ENSP00000399811  

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antibodies-online proteins for CELA2B (3 products) 

 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry P08218

ProtoNet protein and cluster: P08218

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


Find genes that share domains with CELA2B           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CEL2B_HUMAN, P08218
Function: Acts upon elastin
Catalytic activity: Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastin

     Enzyme Numbers (IUBMB): EC 3.4.21.711 2 EC 3.4.212

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
     
Find genes that share ontologies with CELA2B           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for CELA2B

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CEL2B_HUMAN, P08218: Secreted
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular5
lysosome1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CELA2B About    
See pathways by source

SuperPathContained pathways About
1Protein digestion and absorption
Protein digestion and absorption
2Pancreatic secretion
Pancreatic secretion


Find genes that share SuperPaths with CELA2B           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways



2 Kegg Pathways  (Kegg details for CELA2B):
    Pancreatic secretion
Protein digestion and absorption

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CELA2B
Interactions:

    Search GeneGlobe Interaction Network for CELA2B

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

Selected Interacting proteins for CELA2B (ENSP000003650754) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
InteractantInteraction Details
GeneCardExternal ID(s)
MED31ENSP000002257284STRING: ENSP00000225728
CPA5ENSP000003475494STRING: ENSP00000347549
MED18ENSP000003629484STRING: ENSP00000362948
NGFENSP000003585254STRING: ENSP00000358525
DNAJC3ENSP000003659914STRING: ENSP00000365991
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006508proteolysis ----

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CELA2B (CEL2B)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for CELA2B gene: 
NM_015849.2  

Unigene Cluster for CELA2B:

Chymotrypsin-like elastase family, member 2B
Hs.631871  [show with all ESTs]
Unigene Representative Sequence: NM_015849
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000494280 ENST00000375910(uc001awl.3) ENST00000422901 ENST00000488764

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Additional mRNA sequence: 

BC069412.1 BC069455.1 BC113540.1 BC113542.1 M16653.1 

3 DOTS entries:

DT.100738366  DT.100000320  DT.100031124 

Selected AceView cDNA sequences (see all 216):

CA941029 CA848657 AA366316 CA842060 AA366517 BM354125 CA773928 CA942036 
BQ632768 BM311580 BU950653 CA867358 BU071824 BM510081 BQ787677 BQ268273 
CB069667 CA867641 BQ614356 AA309295 BU079099 CA942969 CA942306 BC007031 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CELA2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCATCGGCAG
CELA2B Expression
About this image

CELA2B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CELA2B Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.631871

UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218
Tissue specificity: Pancreas

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for CELA2B gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves CELA2A6
Gallus gallus chymotrypsin-like elastase family, m...
67(a)
1 → many
21(5542650-5547423)
zebrafish
(Danio rerio)
Actinopterygii ela3l6
elastase 3 like
61(a)
many ↔ many
5(27756145-27763404) ENSDARG00000007276
        Species with no ortholog for CELA2B

ENSEMBL Gene Tree for CELA2B (if available)
TreeFam Gene Tree for CELA2B (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CELA2B gene
CTRL2  CTRC2  CELA2A2  CELA3B2  CTRB12  CELA12  CELA3A2  CTRB22  
Selected SIMAP similar genes for CELA2B using alignment to 2 protein entries:     CEL2B_HUMAN (see all proteins) (see all similar genes):
ELA2B    CELA2A    ELA2A    CELA1    ACR    CTRC
ELA3A    CELA3A    CELA3B    KLKB1    CTRB1    DESC1
TMPRSS3    HAT    factor IX F9    CTRL    F9 p22    PRSS29P

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1 Pseudogenes.org Pseudogene for CELA2B
PGOHUM00000263035


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CELA2B (see all 454)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 1 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1125001301,2
C--15697915(+) CAAAGA/GCTTGA 1 -- us2k10--------
rs1846921711,2
--15697933(+) TGGGCA/GCGGTG 1 -- us2k10--------
rs1903584351,2
--15698110(+) AGGCAA/GGAGAA 1 -- us2k10--------
rs1149654801,2
F--15698219(+) GCACCT/GGGCTA 1 -- us2k11Minor allele frequency- G:0.03NA 120
rs1493768471,2
--15698226(+) GCTAAC/GTTTTT 1 -- us2k10--------
rs1447365381,2
C--15698236(+) TAAAAG/TAAATT 1 -- us2k10--------
rs358281331,2
C--15698354(+) GGTGCG/AATCTC 1 -- us2k11Minor allele frequency- A:0.50WA 2
rs728651961,2
C,F--15698390(+) GGTTCA/GAGAGG 1 -- us2k13Minor allele frequency- G:0.33WA NA 6
rs358755941,2
C,F--15698537(+) CCGCCC/TGCATC 1 -- us2k18Minor allele frequency- T:0.35NA WA CSA EA 367
rs1817165151,2
C--15698583(+) ACCACA/GTCCGG 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CELA2B (15792404 - 15817895 bp)

Structural Variations
     Database of Genomic Variants (DGV) 4 variations for CELA2B:    About this table    
Variant IDTypeSubtypePubMed ID
esv2744319CNV Deletion23290073
nsv833536CNV Loss17160897
nsv818056CNV Loss17921354
nsv441683CNV CNV18776908

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 609444    OMIM disorders: --

1 disease from the University of Copenhagen DISEASES database for CELA2B:
Pulmonary emphysema

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Genetic Association Database (GAD): CELA2B
Human Genome Epidemiology (HuGE) Navigator: CELA2B (0 documents)

Export disorders for CELA2B gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CELA2B gene integrated from 10 sources:
(articles sorted by number of sources associating them with CELA2B)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PubMed id 3646943)1, 2, 3 Kawashima I.... Takiguchi Y. (DNA 1987)
  2. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PubMed id 16327289)1, 3, 9 Szepessy E. and Sahin-TA^th M. (Pancreatology 2006)
  3. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PubMed id 19773279)1, 4 Hosgood H.D....Lan Q. (Occup Environ Med 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
  6. Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (Blood 2007)
  7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (Nature 2006)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. (PubMed id 3427074)1 Fletcher T.S.... Largman C. (Biochemistry 1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 51032 HGNC: 29995 AceView: ELA2BandELA2A Ensembl:ENSG00000215704 euGenes: HUgn51032
ECgene: CELA2B Kegg: 51032 H-InvDB: CELA2B

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CELA2B Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CELA2B gene:
Search GeneIP for patents involving CELA2B

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(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CELA2B  
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 OriGene Custom Antibody Services for CELA2B   OriGene Custom Protein Services for CELA2B  

 
 
 Block miRNA regulation of human, mouse, rat CELA2B using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CELA2B
 DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CELA2B Predesigned siRNA for gene silencing in human, mouse, rat CELA2B
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 Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CELA2B  Search GeneGlobe Interaction Network for CELA2B
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 GenScript Custom Purified and Recombinant Proteins Services for CELA2B GenScript cDNA clones with any tag delivered in your preferred vector for CELA2B
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 Search Tocris compounds for CELA2B (CEL2B)
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 Novus Tissue Slides
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 Search for Antibodies for CELA2B at Abcam
 See all of Abcam's Antibodies, Kits and Proteins for CELA2B
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 Browse ProSpec Recombinant Proteins
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 Browse ESI BIO Cell Lines and PureStem Progenitors for CELA2B
 Gene Synthesis
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELA2B
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA2B
 Browse compounds at ApexBio
 Search Addgene for plasmids for CELA2B
  Search eBioscience for proteins for CELA2B
  Search eBioscience for elisas for CELA2B
  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for CELA2B
 antibodies-online antibodies for CELA2B
 antibodies-online kits for CELA2B (9 products)
  Search antibodies-online for peptides for CELA2B
 antibodies-online proteins for CELA2B (3 products)
       
GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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