CELA2B Gene
protein-coding GIFtS: 50
GCID: GC01P015792
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|
chymotrypsin-like elastase family, member 2B
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Aliases
for CELA2B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chymotrypsin-Like Elastase Family, Member 2B1 2 | | Elastase 2B2 | | ELA2B1 2 3 5 | | Elastase-2B3 | | EC 3.4.21.713 8 | | Pancreatic Elastase IIB (ELA2B)2 | | RP11-265F14.21 | | Elastase-2B3 | | Chymotrypsin-Like Elastase Family Member 2B2 | | EC 3.4.218 |
Export aliases for CELA2B gene to outside databasesPrevious GC identifers: GC01P015677 GC01P014326 |
Summaries
for CELA2B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CELA2B:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have sixelastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of thehuman elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shownto preferentially cleave proteins after leucine, methionine, and phenylalanine residues. (provided by RefSeq, Jul2008)
UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218Function: Acts upon elastin
Gene Wiki entry for CELA2B
|
Genomic Views
for CELA2B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for CELA2B
Other transcription factors
Search SABiosciences Chromatin IP Primers for CELA2B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA2B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.21CELA2B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P015792: view genomic region
(about GC identifiers)
Start:
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15,792,404 bp from pter |
End:
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15,817,895 bp from pter |
Size:
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25,492 bases |
Orientation:
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plus strand |
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Proteins
for CELA2B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218 (See
protein sequence)Recommended Name: Chymotrypsin-like elastase family member 2B precursor Size: 269 amino acids; 28810 Da
Subcellular location: Secreted
Secondary accessions: Q14D16 Q6ISM5 Q96QV5Explore the universe of human proteins at neXtProt for CELA2B: NX_P08218
4/8 DME Specific Peptides for CELA2B (P08218) (see all 8)
CELA2B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056933.2
ENSEMBL proteins: ENSP00000365075 ENSP00000399811
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CELA2B for ontologies About GeneDecksing
CELA2B Antibody Products:
Assay Products for CELA2B: |
Protein
Domains /
Families
for CELA2B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CELA2B for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P08218ProtoNet protein and cluster: P08218 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218Similarity: Belongs to the peptidase S1 family. Elastase subfamilySimilarity: Contains 1 peptidase S1 domain |
Function
for CELA2B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218Function: Acts upon elastinCatalytic activity: Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastinEnzyme Numbers (IUBMB): EC 3.4.21.711 2 EC 3.4.212
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2B
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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
CELA2B for ontologies About GeneDecksing
|
Pathways & Interactions
for CELA2B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein digestion and absorption | | | 2 | Pancreatic secretion | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Kegg Pathways (Kegg details for CELA2B):
CELA2B for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELA2B
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
CELA2B for ontologies About GeneDecksing
|
Drugs & Compounds
for CELA2B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CELA2B
Search CenterWatch for drugs/clinical trials and news about CELA2B / CEL2B
|
Transcripts
for CELA2B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CELA2B gene: NM_015849.2 Unigene Cluster for CELA2B: Chymotrypsin-like elastase family, member 2B Hs.631871 [show with all ESTs]Unigene Representative Sequence: NM_0158494 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000494280 ENST00000375910(uc001awl.3) ENST00000422901 ENST00000488764
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CELA2B (NM_015849) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CELA2B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA2B |
Additional cDNA sequence: BC069412.1 BC069455.1 BC113540.1 BC113542.1 M16653.1 3 DOTS entries: DT.100738366 DT.100000320 DT.100031124 24/216 AceView cDNA sequences (see all 216): AA309295 BM311580 AA366316 CA867641 BQ614356 BQ632768 CA777153 BX103870 CA773928 CA867358 BM510081 BU079099 BQ286113 AA366517 CA941029 CA842060 CA942969 BU071824 BU950653 BQ787677 CA952678 CA942306 CA848657 CA942036
GeneLoc Exon Structure
|
Expression
for CELA2B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CELA2B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCATCGGCAG
About this image
See CELA2B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CELA2B
SOURCE GeneReport for Unigene cluster: Hs.631871
UniProtKB/Swiss-Prot: CEL2B_HUMAN, P08218Tissue specificity: Pancreas
SABiosciences Custom PCR Arrays for CELA2B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CELA2B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CELA2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA2B |
Orthologs
for CELA2B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CELA2B gene from 3/13 species (see all 13) About this table
ENSEMBL Gene Tree for CELA2B (if available)
TreeFam Gene Tree for CELA2B (if available) |
Paralogs
for CELA2B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CELA2B gene
- CTRL2 CTRC2 CELA2A2 CELA3B2 CELA12 CTRB12 CELA3A2 CTRB22
18/96 SIMAP similar genes for CELA2B using alignment to 2 protein entries: CEL2B_HUMAN (see all proteins)
(see all similar genes):ELA2B CELA2A ELA2A CELA1 ACR CTRC
ELA3A CELA3A CELA3B KLKB1 CTRB1 DESC1
HAT factor IX F9 CTRL F9 p22 PRSS29P PRSS36
CELA2B for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CELA2B
PGOHUM00000263035
|
Genomic Variants
for CELA2B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CELA2B (15792404 - 15817895 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CELA2B
2 CNVs: 9875 38149 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CELA2B |
|
Disorders
/ Diseases
for CELA2B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CELA2B for disorders About GeneDecksing
OMIM gene information: 609444
OMIM disorders: --
3  diseases for CELA2B: About MalaCardspancreatitis pulmonary emphysema emphysema
1 disease from the University of Copenhagen DISEASES database for CELA2B:Pulmonary emphysema Human Genome Epidemiology (HuGE) Navigator: CELA2B (0 documents)
Export disorders for CELA2B gene to outside databases
|
Publications
for CELA2B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CELA2B gene integrated from 9 sources:
(articles sorted by number of sources associating them with CELA2B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PubMed id 3646943)1, 2, 3 Kawashima I.... Takiguchi Y. (1987)
- Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PubMed id 16327289)1, 3, 9 Szepessy E. and Sahin-Toth M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Association between genetic variants in VEGF, ERCC3 a nd occupational benzene haematotoxicity. (PubMed id 19773279)1 Hosgood H.D....Lan Q. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (PubMed id 17192395)1 Macaulay I.C....Ouwehand W.H. (2007)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. (PubMed id 3427074)1 Fletcher T.S.... Largman C. (1987)
|
External Searches for CELA2B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CELA2B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CELA2B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CELA2B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CELA2B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CELA2B gene:
Search GeneIP for patents involving CELA2B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CELA2B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CELA2B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CELA2B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA2B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELA2B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA2B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA2B |
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