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Aliases for CELA2B Gene

Aliases for CELA2B Gene

  • Chymotrypsin-Like Elastase Family, Member 2B 2 3
  • ELA2B 3 4 6
  • EC 3.4.21.71 4 63
  • Elastase-2B 3 4
  • Chymotrypsin-Like Elastase Family Member 2B 3
  • Pancreatic Elastase IIB (ELA2B) 3
  • Pancreatic Elastase IIB 2
  • RP11-265F14.2 3
  • Elastase 2B 3
  • EC 3.4.21 63

External Ids for CELA2B Gene

Previous GeneCards Identifiers for CELA2B Gene

  • GC01P015677
  • GC01P015792
  • GC01P014326

Summaries for CELA2B Gene

Entrez Gene Summary for CELA2B Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2B is secreted from the pancreas as a zymogen. In other species, elastase 2B has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, Jul 2008]

GeneCards Summary for CELA2B Gene

CELA2B (Chymotrypsin-Like Elastase Family, Member 2B) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA3A.

UniProtKB/Swiss-Prot for CELA2B Gene

  • Acts upon elastin

Gene Wiki entry for CELA2B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA2B Gene

Genomics for CELA2B Gene

Genomic Location for CELA2B Gene

Start:
15,465,909 bp from pter
End:
15,491,400 bp from pter
Size:
25,492 bases
Orientation:
Plus strand

Genomic View for CELA2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELA2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA2B Gene

No data available for Regulatory Elements for CELA2B Gene

Proteins for CELA2B Gene

  • Protein details for CELA2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08218-CEL2B_HUMAN
    Recommended name:
    Chymotrypsin-like elastase family member 2B
    Protein Accession:
    P08218
    Secondary Accessions:
    • Q14D16
    • Q6ISM5
    • Q96QV5

    Protein attributes for CELA2B Gene

    Size:
    269 amino acids
    Molecular mass:
    28810 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CELA2B Gene

Proteomics data for CELA2B Gene at MOPED

Selected DME Specific Peptides for CELA2B Gene

Post-translational modifications for CELA2B Gene

No Post-translational modifications

Other Protein References for CELA2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CELA2B Gene

Suggested Antigen Peptide Sequences for CELA2B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08218

UniProtKB/Swiss-Prot:

CEL2B_HUMAN :
  • P08218
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA2B: view

No data available for Gene Families for CELA2B Gene

Function for CELA2B Gene

Molecular function for CELA2B Gene

UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastin
UniProtKB/Swiss-Prot Function: Acts upon elastin

Enzyme Numbers (IUBMB) for CELA2B Gene

Gene Ontology (GO) - Molecular Function for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
genes like me logo Genes that share ontologies with CELA2B: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELA2B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CELA2B Gene

Localization for CELA2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELA2B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CELA2B Gene COMPARTMENTS Subcellular localization image for CELA2B gene
Compartment Confidence
extracellular 5
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CELA2B: view

Pathways for CELA2B Gene

genes like me logo Genes that share pathways with CELA2B: view

Pathways by source for CELA2B Gene

2 KEGG pathways for CELA2B Gene

Interacting Proteins for CELA2B Gene

Gene Ontology (GO) - Biological Process for CELA2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CELA2B: view

Transcripts for CELA2B Gene

mRNA/cDNA for CELA2B Gene

Unigene Clusters for CELA2B Gene

Chymotrypsin-like elastase family, member 2B:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELA2B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CELA2B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CELA2B Gene

No ASD Table

Relevant External Links for CELA2B Gene

GeneLoc Exon Structure for
CELA2B
ECgene alternative splicing isoforms for
CELA2B

Expression for CELA2B Gene

mRNA expression in normal human tissues for CELA2B Gene

mRNA differential expression in normal tissues according to GTEx for CELA2B Gene

This gene is overexpressed in Pancreas (52.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CELA2B Gene

SOURCE GeneReport for Unigene cluster for CELA2B Gene Hs.631871

mRNA Expression by UniProt/SwissProt for CELA2B Gene

P08218-CEL2B_HUMAN
Tissue specificity: Pancreas
genes like me logo Genes that share expressions with CELA2B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CELA2B Gene

Orthologs for CELA2B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CELA2B 35
  • 98.39 (n)
  • 97.4 (a)
cow
(Bos Taurus)
Mammalia ELA2A 36
  • 77 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cela2a 36
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 73 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
OneToMany
chicken
(Gallus gallus)
Aves CELA2A 36
  • 67 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii ela3l 36
  • 61 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for CELA2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA2B Gene

ENSEMBL:
Gene Tree for CELA2B (if available)
TreeFam:
Gene Tree for CELA2B (if available)

Paralogs for CELA2B Gene

Paralogs for CELA2B Gene

Pseudogenes.org Pseudogenes for CELA2B Gene

genes like me logo Genes that share paralogs with CELA2B: view

Variants for CELA2B Gene

Sequence variations from dbSNP and Humsavar for CELA2B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2011159 -- 15,487,256(+) CACTT(C/T)AACTC intron-variant
rs2861484 -- 15,486,170(+) GAAAT(G/T)GTACC intron-variant
rs3060900 -- 15,487,980(+) TCCCC(-/CT)GTCTT intron-variant
rs3737699 -- 15,481,285(+) TACAT(A/G)AAGTA intron-variant
rs3737700 -- 15,481,488(+) CTGGA(A/G)TTGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CELA2B Gene

Variant ID Type Subtype PubMed ID
nsv833536 CNV Loss 17160897
nsv441683 CNV CNV 18776908
esv2744319 CNV Deletion 23290073
nsv818056 CNV Loss 17921354

Relevant External Links for CELA2B Gene

HapMap Linkage Disequilibrium report
CELA2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA2B Gene

Disorders for CELA2B Gene

(1) University of Copenhagen DISEASES for CELA2B Gene

Relevant External Links for CELA2B

Genetic Association Database (GAD)
CELA2B
Human Genome Epidemiology (HuGE) Navigator
CELA2B
genes like me logo Genes that share disorders with CELA2B: view

No data available for UniProtKB/Swiss-Prot for CELA2B Gene

Publications for CELA2B Gene

  1. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PMID: 16327289) Szepessy E. … Sahin-TA^th M. (Pancreatology 2006) 2 3 23
  2. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PMID: 3646943) Kawashima I. … Takiguchi Y. (DNA 1987) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood H.D. … Lan Q. (Occup Environ Med 2009) 3 48
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for CELA2B Gene

  • antibodies-online proteins for CELA2B
  • antibodies-online antibodies for CELA2B
  • antibodies-online kits for CELA2B

Sources for CELA2B Gene

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