CELA2A Gene
protein-coding GIFtS: 53
GCID: GC01P015783
|
|
chymotrypsin-like elastase family, member 2A
| |
Aliases for CELA2A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Chymotrypsin-Like Elastase Family, Member 2A1 2 | | Elastase-2A3 | | ELA2A1 2 3 5 | | Pancreatic Elastase 22 | | EC 3.4.21.713 8 | | Pancreatic Elastase IIA2 | | PE-12 | | Elastase-2A3 | | Chymotrypsin-Like Elastase Family Member 2A2 | | EC 3.4.218 | | Elastase 2A2 | | |
Export aliases for CELA2A gene to outside databasesPrevious GC identifers: GC01P015657 GC01P014303 |
Summaries for CELA2A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for CELA2A: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have sixelastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of thehuman elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shownto preferentially cleave proteins after leucine, methionine, and phenylalanine residues. (provided by RefSeq, May2009) UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217Function: Acts upon elastin Gene Wiki entry for CELA2A
|
Genomic Views for CELA2A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004610.19
Regulatory elements: Search SABiosciences Regulatory transcription factor binding sites for CELA2A Other transcription factors
Search SABiosciences Chromatin IP Primers for CELA2A
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA2A |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.21 Ensembl cytogenetic band: 1p36.21 HGNC cytogenetic band: 1p36.21CELA2A Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P015783: view genomic region
(about GC identifiers)
Start:
|
15,783,223 bp from pter |
End:
|
15,798,586 bp from pter |
Size:
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15,364 bases |
Orientation:
|
plus strand |
|
Proteins for CELA2A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217 (See
protein sequence)Recommended Name: Chymotrypsin-like elastase family member 2A precursor Size: 269 amino acids; 28888 Da
Subunit: Interacts with CPA1
Subcellular location: Secreted
Secondary accessions: B2R5I4 Q14243Explore the universe of human proteins at neXtProt for CELA2A: NX_P08217
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P08217 4/9 DME Specific Peptides for CELA2A (P08217) (see all 9)
CELA2A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_254275.1 ENSEMBL proteins: ENSP00000352639 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CELA2A for ontologies About GeneDecksing
CELA2A Antibody Products: Assay Products for CELA2A: |
Protein
Domains / Families for CELA2A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CELA2A for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P08217ProtoNet protein and cluster: P08217 2 Blocks protein families: IPB001254 Serine protease IPB001314 Chymotrypsin serine protease family (S1) signature
UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217Similarity: Belongs to the peptidase S1 family. Elastase subfamilySimilarity: Contains 1 peptidase S1 domain |
Function for CELA2A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217Function: Acts upon elastinCatalytic activity: Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastinEnzyme Numbers (IUBMB): EC 3.4.21.711 2 EC 3.4.212
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CELA2A (NM_033440) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CELA2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA2A  |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004252 | serine-type endopeptidase activity |
IEA | -- |
CELA2A for ontologies About GeneDecksing
|
Pathways & Interactions for CELA2A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
| Unified GeneCards pathways  About this table  See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Protein digestion and absorption | | | 2 | Pancreatic secretion | |
Pathway sources See GeneCards unified pathways Show all pathways
2
Kegg Pathways (Kegg details for CELA2A):
CELA2A for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELA2A
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006508 | proteolysis |
IEA | -- |
CELA2A for ontologies About GeneDecksing
|
Drugs & Compounds for CELA2A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CELA2A for compounds About GeneDecksing
Browse Tocris compounds for CELA2A
1 DrugBank Compound for CELA2A About this table
1 Novoseek chemical compound relationship for CELA2A gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| chymostatin |
76.1 |
1 |
12714330 (1) |
Search CenterWatch for drugs/clinical trials and news about CELA2A / CEL2A 
|
Transcripts for CELA2A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for CELA2A gene: NM_033440.2 Unigene Cluster for CELA2A: Chymotrypsin-like elastase family, member 2A Hs.631866 [show with all ESTs]Unigene Representative Sequence: AK0566783 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000459653 ENST00000359621(uc001awk.3) ENST00000497590
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2A (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CELA2A OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CELA2A (NM_033440) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CELA2A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA2A  |
Additional cDNA sequence: AK056678.1 AK312198.1 BC007031.1 BC069331.1 BC069432.1 CR450291.1 D00236.1 M16631.1 M16652.1 4 DOTS entries: DT.453809 DT.91698724 DT.100031123 DT.100738366 24/216 AceView cDNA sequences (see all 216): CA941029 CA848657 BC007031 BQ286113 AA366517 CA942306 CA942969 CA867358 BX103870 CA773928 CA777153 BQ632768 AA366316 CA867641 BQ268273 BQ614356 BM510081 CA942036 BQ787677 CA952678 CA842060 BU950653 BU071824 BM354125 GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CELA2A (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | |
| SP1: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | - |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for CELA2A
|
Expression for CELA2A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CELA2A expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AGGACTAAGT
About this image See CELA2A Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CELA2A
SOURCE GeneReport for Unigene cluster: Hs.631866 UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217Tissue specificity: Pancreas. Not detected in keratinocytes SABiosciences Custom PCR Arrays for CELA2A
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CELA2A Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CELA2A | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA2A | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA2A |
Orthologs for CELA2A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CELA2A gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for CELA2A (if available) TreeFam Gene Tree for CELA2A (if available)  |
Paralogs for CELA2A gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for CELA2A gene
- CTRL2 CTRC2 CELA3B2 CELA12 CTRB12 CELA3A2 CELA2B2 CTRB22
18/108 SIMAP similar genes for CELA2A using alignment to 1 protein entry: CEL2A_HUMAN(see all similar genes):ELA2A ELA2B CELA1 CELA2B CTRC CELA3A CELA3B ELA3A CTRB1 CTRL TMPRSS11F CTRB2 DESC1 HPN TMPRSS11D TMPRSS11E TMPRSS7 TMPRSS9
CELA2A for paralogs About GeneDecksing
|
Genomic Variants for CELA2A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 1 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for CELA2A (15783223 - 15798586 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for CELA2A 2 CNVs: 9875 38149  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CELA2A |
|
Disorders
/ Diseases for CELA2A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CELA2A for disorders About GeneDecksing
OMIM gene information: 609443
OMIM disorders: --
5 diseases for CELA2A: About MalaCardspancreatitis acute pancreatitis duodenitis prostate cancer prostatitis
1 Novoseek disease relationship for CELA2A gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| chronic pancreatitis |
42.9 |
2 |
15481311 (1) |
Human Genome Epidemiology (HuGE) Navigator: CELA2A (3 documents) Export disorders for CELA2A gene to outside databases
|
Publications for CELA2A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CELA2A gene, integrated from 9 sources (see all 30): (articles sorted by number of sources associating them with CELA2A) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PubMed id 3646943)1, 2, 3 Kawashima I.... Takiguchi Y. (1987)
- Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. (PubMed id 2834346)1, 2, 3 Shirasu Y.... Ikenaga H. (1987)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. (PubMed id 2307232)1, 2 Moulard M.... Chapus C. (1990)
- Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. (PubMed id 3427074)1, 2 Fletcher T.S.... Largman C. (1987)
- Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PubMed id 16327289)1, 9 Szepessy E. and Sahin-Toth M. (2006)
- Identification of disease-specific genes in chronic pancreatitis using DNA array technology. (PubMed id 11729383)1, 9 Friess H....Buchler M.W. (2001)
- Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1 Kerns S.L....Rosenstein B.S. (2010)
|
External Searches for CELA2A gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CELA2A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CELA2A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CELA2A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for CELA2A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CELA2A gene: Search GeneIP for patents involving CELA2A
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for CELA2A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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