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Aliases for CELA2A Gene

Aliases for CELA2A Gene

  • Chymotrypsin-Like Elastase Family, Member 2A 2 3
  • ELA2A 3 4 6
  • EC 4 63
  • Elastase 2A 2 3
  • Elastase-2A 3 4
  • Chymotrypsin-Like Elastase Family Member 2A 3
  • Pancreatic Elastase IIA 3
  • Pancreatic Elastase 2 3
  • EC 3.4.21 63
  • PE-1 3

External Ids for CELA2A Gene

Previous GeneCards Identifiers for CELA2A Gene

  • GC01P015657
  • GC01P015783
  • GC01P014303

Summaries for CELA2A Gene

Entrez Gene Summary for CELA2A Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]

GeneCards Summary for CELA2A Gene

CELA2A (Chymotrypsin-Like Elastase Family, Member 2A) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

UniProtKB/Swiss-Prot for CELA2A Gene

  • Acts upon elastin

Gene Wiki entry for CELA2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA2A Gene

Genomics for CELA2A Gene

Genomic Location for CELA2A Gene

15,456,728 bp from pter
15,472,091 bp from pter
15,364 bases
Plus strand

Genomic View for CELA2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA2A Gene

No data available for Regulatory Elements for CELA2A Gene

Proteins for CELA2A Gene

  • Protein details for CELA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Chymotrypsin-like elastase family member 2A
    Protein Accession:
    Secondary Accessions:
    • B2R5I4
    • Q14243

    Protein attributes for CELA2A Gene

    269 amino acids
    Molecular mass:
    28888 Da
    Quaternary structure:
    • Interacts with CPA1.

neXtProt entry for CELA2A Gene

Proteomics data for CELA2A Gene at MOPED

Selected DME Specific Peptides for CELA2A Gene

Post-translational modifications for CELA2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CELA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CELA2A Gene

Suggested Antigen Peptide Sequences for CELA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • P08217
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with CELA2A: view

No data available for Gene Families for CELA2A Gene

Function for CELA2A Gene

Molecular function for CELA2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastin
UniProtKB/Swiss-Prot Function: Acts upon elastin

Enzyme Numbers (IUBMB) for CELA2A Gene

Gene Ontology (GO) - Molecular Function for CELA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0017171 serine hydrolase activity IDA 20179351
genes like me logo Genes that share ontologies with CELA2A: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELA2A

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CELA2A Gene

Localization for CELA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELA2A Gene


Subcellular locations from

Jensen Localization Image for CELA2A Gene COMPARTMENTS Subcellular localization image for CELA2A gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CELA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0036457 keratohyalin granule IDA 20179351
genes like me logo Genes that share ontologies with CELA2A: view

Pathways for CELA2A Gene

genes like me logo Genes that share pathways with CELA2A: view

Pathways by source for CELA2A Gene

2 KEGG pathways for CELA2A Gene

Interacting Proteins for CELA2A Gene

Gene Ontology (GO) - Biological Process for CELA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CELA2A: view

Compounds for CELA2A Gene

(1) Drugbank Compounds for CELA2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs

(1) Novoseek inferred chemical compound relationships for CELA2A Gene

Compound -log(P) Hits PubMed IDs
chymostatin 76.1 1
genes like me logo Genes that share compounds with CELA2A: view

Transcripts for CELA2A Gene

mRNA/cDNA for CELA2A Gene

Unigene Clusters for CELA2A Gene

Chymotrypsin-like elastase family, member 2A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CELA2A

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CELA2A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - - - -
SP5: -

Relevant External Links for CELA2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CELA2A Gene

mRNA expression in normal human tissues for CELA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA2A Gene

This gene is overexpressed in Pancreas (52.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CELA2A Gene

SOURCE GeneReport for Unigene cluster for CELA2A Gene Hs.631866

mRNA Expression by UniProt/SwissProt for CELA2A Gene

Tissue specificity: Pancreas. Not detected in keratinocytes.
genes like me logo Genes that share expressions with CELA2A: view

In Situ Assay Products

Orthologs for CELA2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CELA2A 35
  • 98.88 (n)
  • 99.26 (a)
  • 99 (a)
(Bos Taurus)
Mammalia CELA2A 35
  • 84.14 (n)
  • 79.93 (a)
ELA2A 36
  • 81 (a)
(Mus musculus)
Mammalia Cela2a 35
  • 76.58 (n)
  • 75.09 (a)
Cela2a 16
Cela2a 36
  • 75 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
(Rattus norvegicus)
Mammalia Cela2a 35
  • 81.16 (n)
  • 83.27 (a)
(Gallus gallus)
Aves CELA2A 35
  • 70.11 (n)
  • 70.88 (a)
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498609 35
  • 63.44 (n)
  • 63.2 (a)
Str.8626 35
(Danio rerio)
Actinopterygii ela2l 35
  • 65.16 (n)
  • 66.17 (a)
ela3l 36
  • 62 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for CELA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA2A Gene

Gene Tree for CELA2A (if available)
Gene Tree for CELA2A (if available)

Paralogs for CELA2A Gene

Paralogs for CELA2A Gene

genes like me logo Genes that share paralogs with CELA2A: view

Variants for CELA2A Gene

Sequence variations from dbSNP and Humsavar for CELA2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs504468 -- 15,454,948(+) GCCAA(C/T)ATGGT upstream-variant-2KB
rs532633 -- 15,455,675(+) CCCAC(A/G)TTATA upstream-variant-2KB
rs565421 -- 15,455,633(+) ACCTT(C/T)CCCGC upstream-variant-2KB
rs1042010 -- 15,467,418(+) CAGGC(A/G)TCTGA synonymous-codon, reference
rs2303193 - 15,467,516(-) TGTAA(C/T)TGGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CELA2A Gene

Variant ID Type Subtype PubMed ID
nsv833536 CNV Loss 17160897
esv2744308 CNV Deletion 23290073
nsv441683 CNV CNV 18776908
esv2744319 CNV Deletion 23290073
nsv818056 CNV Loss 17921354

Relevant External Links for CELA2A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA2A Gene

Disorders for CELA2A Gene

(1) Novoseek inferred disease relationships for CELA2A Gene

Disease -log(P) Hits PubMed IDs
chronic pancreatitis 42.9 1

Relevant External Links for CELA2A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CELA2A: view

No data available for UniProtKB/Swiss-Prot for CELA2A Gene

Publications for CELA2A Gene

  1. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. (PMID: 2834346) Shirasu Y. … Ikenaga H. (J. Biochem. 1987) 2 3 4
  2. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PMID: 3646943) Kawashima I. … Takiguchi Y. (DNA 1987) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. (PMID: 3427074) Fletcher T.S. … Largman C. (Biochemistry 1987) 3 4
  5. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PMID: 16327289) Szepessy E. … Sahin-TA^th M. (Pancreatology 2006) 3 23

Products for CELA2A Gene

Sources for CELA2A Gene

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