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Aliases for CELA2A Gene

Aliases for CELA2A Gene

  • Chymotrypsin-Like Elastase Family, Member 2A 2 3
  • ELA2A 3 4 6
  • EC 3.4.21.71 4 63
  • Elastase 2A 2 3
  • Elastase-2A 3 4
  • Chymotrypsin-Like Elastase Family Member 2A 3
  • Pancreatic Elastase IIA 3
  • Pancreatic Elastase 2 3
  • EC 3.4.21 63
  • PE-1 3

External Ids for CELA2A Gene

Summaries for CELA2A Gene

Entrez Gene Summary for CELA2A Gene

  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]

GeneCards Summary for CELA2A Gene

CELA2A (Chymotrypsin-Like Elastase Family, Member 2A) is a Protein Coding gene. Among its related pathways are Pancreatic secretion and Protein digestion and absorption. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CELA2B.

UniProtKB/Swiss-Prot for CELA2A Gene

  • Acts upon elastin

Gene Wiki entry for CELA2A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CELA2A Gene

Genomics for CELA2A Gene

Genomic Location for CELA2A Gene

Start:
15,456,728 bp from pter
End:
15,472,091 bp from pter
Size:
15,364 bases
Orientation:
Plus strand

Genomic View for CELA2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CELA2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CELA2A Gene

No data available for Regulatory Elements for CELA2A Gene

Proteins for CELA2A Gene

  • Protein details for CELA2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P08217-CEL2A_HUMAN
    Recommended name:
    Chymotrypsin-like elastase family member 2A
    Protein Accession:
    P08217
    Secondary Accessions:
    • B2R5I4
    • Q14243

    Protein attributes for CELA2A Gene

    Size:
    269 amino acids
    Molecular mass:
    28888 Da
    Quaternary structure:
    • Interacts with CPA1.

neXtProt entry for CELA2A Gene

Proteomics data for CELA2A Gene at MOPED

Selected DME Specific Peptides for CELA2A Gene

Post-translational modifications for CELA2A Gene

No Post-translational modifications

Other Protein References for CELA2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CELA2A Gene

Suggested Antigen Peptide Sequences for CELA2A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P08217

UniProtKB/Swiss-Prot:

CEL2A_HUMAN
Domain:
  • Contains 1 peptidase S1 domain.:
    • P08217
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.:
    • P08217
genes like me logo Genes that share domains with CELA2A: view

No data available for Gene Families for CELA2A Gene

Function for CELA2A Gene

Molecular function for CELA2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastin
UniProtKB/Swiss-Prot Function: Acts upon elastin

Enzyme Numbers (IUBMB) for CELA2A Gene

Gene Ontology (GO) - Molecular Function for CELA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004252 serine-type endopeptidase activity IEA --
GO:0017171 serine hydrolase activity IDA 20179351
genes like me logo Genes that share ontologies with CELA2A: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CELA2A Gene

Localization for CELA2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CELA2A Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CELA2A Gene COMPARTMENTS Subcellular localization image for CELA2A gene
Compartment Confidence
extracellular 5
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CELA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0036457 keratohyalin granule IDA 20179351
genes like me logo Genes that share ontologies with CELA2A: view

Pathways for CELA2A Gene

genes like me logo Genes that share pathways with CELA2A: view

Pathways by source for CELA2A Gene

2 KEGG pathways for CELA2A Gene

Interacting Proteins for CELA2A Gene

Gene Ontology (GO) - Biological Process for CELA2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
genes like me logo Genes that share ontologies with CELA2A: view

Compounds for CELA2A Gene

(1) Drugbank Compounds for CELA2A Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2-(2-HYDROXY-CYCLOPENTYL)-PENT-4-ENAL
target

(1) Novoseek inferred chemical compound relationships for CELA2A Gene

Compound -log(P) Hits PubMed IDs
chymostatin 76.1 1
genes like me logo Genes that share compounds with CELA2A: view

Transcripts for CELA2A Gene

mRNA/cDNA for CELA2A Gene

Unigene Clusters for CELA2A Gene

Chymotrypsin-like elastase family, member 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CELA2A Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - - - - - - -
SP5: -
SP6:

Relevant External Links for CELA2A Gene

GeneLoc Exon Structure for
CELA2A
ECgene alternative splicing isoforms for
CELA2A

Expression for CELA2A Gene

mRNA expression in normal human tissues for CELA2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CELA2A Gene

This gene is overexpressed in Pancreas (52.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CELA2A Gene

SOURCE GeneReport for Unigene cluster for CELA2A Gene Hs.631866

mRNA Expression by UniProt/SwissProt for CELA2A Gene

P08217-CEL2A_HUMAN
Tissue specificity: Pancreas. Not detected in keratinocytes.
genes like me logo Genes that share expressions with CELA2A: view

Orthologs for CELA2A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CELA2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CELA2A 35
  • 98.88 (n)
  • 99.26 (a)
CELA2A 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CELA2A 35
  • 84.14 (n)
  • 79.93 (a)
ELA2A 36
  • 81 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cela2a 35
  • 76.58 (n)
  • 75.09 (a)
Cela2a 16
Cela2a 36
  • 75 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 77 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cela2a 35
  • 81.16 (n)
  • 83.27 (a)
chicken
(Gallus gallus)
Aves CELA2A 35
  • 70.11 (n)
  • 70.88 (a)
CELA2A 36
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498609 35
  • 63.44 (n)
  • 63.2 (a)
Str.8626 35
zebrafish
(Danio rerio)
Actinopterygii ela2l 35
  • 65.16 (n)
  • 66.17 (a)
ela3l 36
  • 62 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToMany
Species with no ortholog for CELA2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CELA2A Gene

ENSEMBL:
Gene Tree for CELA2A (if available)
TreeFam:
Gene Tree for CELA2A (if available)

Paralogs for CELA2A Gene

Paralogs for CELA2A Gene

genes like me logo Genes that share paralogs with CELA2A: view

Variants for CELA2A Gene

Sequence variations from dbSNP and Humsavar for CELA2A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs504468 -- 15,454,948(+) GCCAA(C/T)ATGGT upstream-variant-2KB
rs532633 -- 15,455,675(+) CCCAC(A/G)TTATA upstream-variant-2KB
rs565421 -- 15,455,633(+) ACCTT(C/T)CCCGC upstream-variant-2KB
rs2819550 -- 15,455,532(-) TTCAT(C/T)TGGTG upstream-variant-2KB
rs2303196 -- 15,456,886(+) CCAAC(C/T)CCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CELA2A Gene

Variant ID Type Subtype PubMed ID
nsv833536 CNV Loss 17160897
esv2744308 CNV Deletion 23290073
nsv441683 CNV CNV 18776908
esv2744319 CNV Deletion 23290073
nsv818056 CNV Loss 17921354

Relevant External Links for CELA2A Gene

HapMap Linkage Disequilibrium report
CELA2A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CELA2A Gene

Disorders for CELA2A Gene

(1) Novoseek inferred disease relationships for CELA2A Gene

Disease -log(P) Hits PubMed IDs
chronic pancreatitis 42.9 1

Relevant External Links for CELA2A

Genetic Association Database (GAD)
CELA2A
Human Genome Epidemiology (HuGE) Navigator
CELA2A
genes like me logo Genes that share disorders with CELA2A: view

No data available for UniProtKB/Swiss-Prot for CELA2A Gene

Publications for CELA2A Gene

  1. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. (PMID: 2834346) Shirasu Y. … Ikenaga H. (J. Biochem. 1987) 2 3 4
  2. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PMID: 3646943) Kawashima I. … Takiguchi Y. (DNA 1987) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. (PMID: 3427074) Fletcher T.S. … Largman C. (Biochemistry 1987) 3 4
  5. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PMID: 16327289) Szepessy E. … Sahin-TA^th M. (Pancreatology 2006) 3 23

Products for CELA2A Gene

Sources for CELA2A Gene

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