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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CELA2A Gene

protein-coding   GIFtS: 55
GCID: GC01P015783

Chymotrypsin-Like Elastase Family, Member 2A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chymotrypsin-Like Elastase Family, Member 2A1 2     elastase-2A2
ELA2A2 3 5     Pancreatic Elastase 22
Elastase 2A1 2     Pancreatic Elastase IIA2
EC 3.4.21.713 8     Elastase-2A3
PE-12     EC 3.4.218
Chymotrypsin-Like Elastase Family Member 2A2     

External Ids:    HGNC: 246091   Entrez Gene: 630362   Ensembl: ENSG000001426157   OMIM: 6094435   UniProtKB: P082173   

Export aliases for CELA2A gene to outside databases

Previous GC identifers: GC01P015657 GC01P014303


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CELA2A Gene:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have
six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of
the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has
been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. (provided by
RefSeq, May 2009)

GeneCards Summary for CELA2A Gene: 
CELA2A (chymotrypsin-like elastase family, member 2A) is a protein-coding gene. Diseases associated with CELA2A include pancreatitis, and acute pancreatitis. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRL.

UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217
Function: Acts upon elastin

Gene Wiki entry for CELA2A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CELA2A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELA2A promoter sequence
   Search SABiosciences Chromatin IP Primers for CELA2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA2A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.21   Ensembl cytogenetic band:  1p36.21   HGNC cytogenetic band: 1p36.21

CELA2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELA2A gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P015783:  view genomic region     (about GC identifiers)

Start:
15,783,223 bp from pter      End:
15,798,586 bp from pter
Size:
15,364 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217 (See protein sequence)
Recommended Name: Chymotrypsin-like elastase family member 2A precursor  
Size: 269 amino acids; 28888 Da
Subunit: Interacts with CPA1
Subcellular location: Secreted
Secondary accessions: B2R5I4 Q14243

Explore the universe of human proteins at neXtProt for CELA2A: NX_P08217

Explore proteomics data for CELA2A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P08217

  • 4/9 DME Specific Peptides for CELA2A (P08217) (see all 9)
     GDSGGPL  WPWQVSL  VLTAAHC  WWGSSVK 

    CELA2A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CELA2A Protein Expression
    REFSEQ proteins: NP_254275.1  
    ENSEMBL proteins: 
     ENSP00000352639  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CELA2A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry P08217

    ProtoNet protein and cluster: P08217

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217
    Similarity: Belongs to the peptidase S1 family. Elastase subfamily
    Similarity: Contains 1 peptidase S1 domain


    CELA2A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEL2A_HUMAN, P08217
    Function: Acts upon elastin
    Catalytic activity: Preferential cleavage: Leu- -Xaa, Met- -Xaa and Phe- -Xaa. Hydrolyzes elastin

         Enzyme Numbers (IUBMB): EC 3.4.21.711 2 EC 3.4.212

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
         
    CELA2A for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CELA2A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Protein digestion and absorption
    Protein digestion and absorption
    2Pancreatic secretion
    Pancreatic secretion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    2         Kegg Pathways  (Kegg details for CELA2A):
        Pancreatic secretion
    Protein digestion and absorption


    CELA2A for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELA2A

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--

    CELA2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CELA2A for compounds           About GeneDecksing

    EMD Millipore small molecules for CELA2A:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CELA2A (CEL2A)

    1 DrugBank Compound for CELA2A    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-(2-HYDROXY-CYCLOPENTYL)-PENT-4-ENAL-- --target--10592235

    1 Novoseek inferred chemical compound relationship for CELA2A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chymostatin 76.1 1 12714330 (1)

    Search CenterWatch for drugs/clinical trials and news about CELA2A / CEL2A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CELA2A gene: 
    NM_033440.2  

    Unigene Cluster for CELA2A:

    Chymotrypsin-like elastase family, member 2A
    Hs.631866  [show with all ESTs]
    Unigene Representative Sequence: AK056678
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000459653 ENST00000359621(uc001awk.3) ENST00000497590
    miRNA
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    Additional mRNA sequence: 

    AK056678.1 AK312198.1 BC007031.1 BC069331.1 BC069432.1 CR450291.1 D00236.1 M16631.1 
    M16652.1 

    4 DOTS entries:

    DT.453809  DT.91698724  DT.100031123  DT.100738366 

    24/216 AceView cDNA sequences (see all 216):

    CA867641 BU071824 CA773928 AA366316 NM_033440 BQ286113 CA867358 CA848657 
    BQ268273 BX103870 BC007031 BU079099 AA309295 CA942306 BQ787677 BM311580 
    CA952678 AA366922 BQ632768 BM510081 CB069667 CA777153 BQ614356 BU950653 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CELA2A (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b
    SP1:                          -                       -           -                                       
    SP2:                          -                 -     -           -                                       
    SP3:                          -                       -                                                   
    SP4:                          -           -     -     -     -     -     -                                 
    SP5:                          -                                                                           


    ECgene alternative splicing isoforms for CELA2A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CELA2A expression in normal human tissues (normalized intensities)      CELA2A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGGACTAAGT
    CELA2A Expression
    About this image


    CELA2A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Pancreatic Islet   

    See CELA2A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CELA2A

    SOURCE GeneReport for Unigene cluster: Hs.631866

    UniProtKB/Swiss-Prot: CEL2A_HUMAN, P08217
    Tissue specificity: Pancreas. Not detected in keratinocytes

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CELA2A gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cela2a1 , 5 chymotrypsin-like elastase family, member 2A1, 5 76.58(n)1
    75.09(a)1
      4 (74.75 cM)5
    137061  NM_007919.21  NP_031945.11 
     1418149625 
    chicken
    (Gallus gallus)
    Aves CELA2A1 chymotrypsin-like elastase family, member 2A 70.11(n)
    70.88(a)
      419486  NM_001032390.2  NP_001027562.2 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.86262 Transcribed sequence with weak similarity to protein more 74.75(n)    CF374140.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ela2l1 elastase 2 like 65.16(n)
    66.17(a)
      334304  NM_199886.1  NP_956180.1 


    ENSEMBL Gene Tree for CELA2A (if available)
    TreeFam Gene Tree for CELA2A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CELA2A gene
    CTRL2  CTRC2  CELA3B2  CELA12  CTRB12  CELA3A2  CELA2B2  OVCH22  
    CTRB22  OVCH12  
    18/102 SIMAP similar genes for CELA2A using alignment to 1 protein entry:     CEL2A_HUMAN(see all similar genes):
    ELA2A    ELA2B    CELA1    CELA2B    CTRC    CELA3A
    CELA3B    ELA3A    CTRB1    CTRL    TMPRSS11F    CTRB2
    DESC1    TMPRSS11D    TMPRSS11E    TMPRSS7    TMPRSS9    serase-1B

    CELA2A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/548 SNPs in CELA2A are shown (see all 548)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5412961,2
    C,F,O,A,H--14301025(+) CCCACC/TCATTT 1 -- us2k112Minor allele frequency- T:0.38NS EA WA NA CSA 786
    rs561523721,2
    C--15696119(+) AAAAA-/A/AA  
            
    GAATT
    1 -- ds50011NA 2
    rs286517691,2
    --15781278(+) GGAAAC/GTAAGG 1 -- us2k10--------
    rs1930489341,2
    --15781329(+) ATTGAC/TGGATC 1 -- us2k10--------
    rs1845422641,2
    --15781346(+) TTGAAC/TTCGGC 1 -- us2k10--------
    rs1469160071,2
    C--15781431(+) AAGACC/TAGCCT 1 -- us2k10--------
    rs5044681,2
    C--15781443(+) GCCAAC/TATGGT 1 -- us2k10--------
    rs1415514951,2
    --15781448(+) TATGGC/TGAAAC 1 -- us2k10--------
    rs1470523451,2
    C--15781454(+) GAAACC/TCCGTC 1 -- us2k10--------
    rs350842171,2
    C,F--15781502(+) CGGTGC/TCTGTA 1 -- us2k12Minor allele frequency- T:0.50WA NA 4

    HapMap Linkage Disequilibrium report for CELA2A (15783223 - 15798586 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CELA2A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2744319CNV Deletion23290073
    esv2744308CNV Deletion23290073
    nsv833536CNV Loss17160897
    nsv818056CNV Loss17921354
    nsv441683CNV CNV18776908

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609443    OMIM disorders: --

    5 diseases for CELA2A:    About MalaCards
    pancreatitis    acute pancreatitis    duodenitis    prostate cancer
    prostatitis


    CELA2A for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for CELA2A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chronic pancreatitis 42.9 2 15481311 (1)

    Genetic Association Database (GAD): CELA2A
    Human Genome Epidemiology (HuGE) Navigator: CELA2A (3 documents)

    Export disorders for CELA2A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CELA2A gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CELA2A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas. (PubMed id 3646943)1, 2, 3 Kawashima I.... Takiguchi Y. (1987)
    2. Molecular cloning and expression in Escherichia coli of a cDNA encoding human pancreatic elastase 2. (PubMed id 2834346)1, 2, 3 Shirasu Y.... Ikenaga H. (1987)
    3. Genome-wide association study to identify single nucl eotide polymorphisms (SNPs) associated with the development of erectile dysfunc tion in African-American men after radiotherapy for prostate cancer. (PubMed id 20932654)1, 4 Kerns S.L....Rosenstein B.S. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Further studies on the human pancreatic binary complexes involving procarboxypeptidase A. (PubMed id 2307232)1, 2 Moulard M.... Chapus C. (1990)
    9. Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA. (PubMed id 3427074)1, 2 Fletcher T.S.... Largman C. (1987)
    10. Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans. (PubMed id 16327289)1, 9 Szepessy E. and Sahin-Toth M. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 63036 HGNC: 24609 AceView: ELA2BandELA2A Ensembl:ENSG00000142615 euGenes: HUgn63036
    ECgene: CELA2A Kegg: 63036 H-InvDB: CELA2A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CELA2A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CELA2A gene:
    Search GeneIP for patents involving CELA2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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