Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CELA1 Gene

protein-coding   GIFtS: 54
GCID: GC12M051723

Chymotrypsin-Like Elastase Family, Member 1

(Previous names: elastase 1, pancreatic)
(Previous symbol: ELA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chymotrypsin-Like Elastase Family, Member 11 2     Chymotrypsin-Like Elastase Family Member 12
ELA11 2 3 5     elastase-12
Elastase 1, Pancreatic1 2     Elastase-13
Pancreatic Elastase 12 3     EC 3.4.218
EC 3.4.21.363 8     

External Ids:    HGNC: 33081   Entrez Gene: 19902   Ensembl: ENSG000001396107   OMIM: 1301205   UniProtKB: Q9UNI13   

Export aliases for CELA1 gene to outside databases

Previous GC identifers: GC12M050012 GC12M048755


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CELA1 Gene:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have
six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other
elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been
detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or
fecal material is actually referring to chymotrypsin-like elastase family, member 3B. (provided by RefSeq, May
2009)

GeneCards Summary for CELA1 Gene: 
CELA1 (chymotrypsin-like elastase family, member 1) is a protein-coding gene. Diseases associated with CELA1 include pancreatic steatorrhea, and pancreatitis. GO annotations related to this gene include metal ion binding and serine-type endopeptidase activity. An important paralog of this gene is CTRL.

UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1
Function: Acts upon elastin

Gene Wiki entry for CELA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CELA1 gene promoter:
         AML1a   Tal-1   Pax-6   CBF-C   E47   PPAR-gamma1   CBF-A   CBF-B   PPAR-gamma2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELA1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CELA1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

CELA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051723:  view genomic region     (about GC identifiers)

Start:
51,722,227 bp from pter      End:
51,740,463 bp from pter
Size:
18,237 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1 (See protein sequence)
Recommended Name: Chymotrypsin-like elastase family member 1 precursor  
Size: 258 amino acids; 27798 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Subcellular location: Secreted
Caution: In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase
activity described in the pancreas may be in fact due to CELA2A (PubMed:10620133)
Sequence caution: Sequence=AAV88109.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5MLF0 Q6DJT0 Q6ISM6

Explore the universe of human proteins at neXtProt for CELA1: NX_Q9UNI1

Explore proteomics data for CELA1 at MOPED 

4/11 DME Specific Peptides for CELA1 (Q9UNI1) (see all 11)
 CYITGWG  VMTAAHC  GDSGGPL  YVQLGVLP 

CELA1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CELA1 Protein Expression
REFSEQ proteins: NP_001962.3  
ENSEMBL proteins: 
 ENSP00000293636  

Human Recombinant Protein Products for CELA1: 
Browse Purified and Recombinant Proteins at EMD Millipore
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate for CELA1
OriGene Custom MassSpec 
OriGene Custom Protein Services for CELA1
GenScript Custom Purified and Recombinant Proteins Services for CELA1
Novus Biologicals CELA1 Proteins
Novus Biologicals CELA1 Lysate
Browse Sino Biological Recombinant Proteins
Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

CELA1 for ontologies           About GeneDecksing



CELA1 Antibody Products: 
Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
OriGene Custom Antibody Services for CELA1
GenScript Custom Superior Antibodies Services for CELA1
Novus Biologicals CELA1 Antibodies
Abcam antibodies for CELA1
Browse Antibodies at Cloud-Clone Corp. 
Search ThermoFisher Antibodies for CELA1
LSBio Antibodies in human, mouse, rat for CELA1 

Assay Products for CELA1: 
Browse Kits and Assays available from EMD Millipore
OriGene Custom Assay Services for CELA1
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for CELA1
Browse Enzo Life Sciences for kits & assays
Browse ELISAs at Cloud-Clone Corp. 
Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR001314 Peptidase_S1A
 IPR001254 Peptidase_S1
 IPR018114 Peptidase_S1_AS
 IPR009003 Trypsin-like_Pept_dom

Graphical View of Domain Structure for InterPro Entry Q9UNI1

ProtoNet protein and cluster: Q9UNI1

2 Blocks protein domains:
IPB001254 Serine protease
IPB001314 Chymotrypsin serine protease family (S1) signature


UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1
Similarity: Belongs to the peptidase S1 family. Elastase subfamily
Similarity: Contains 1 peptidase S1 domain


CELA1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: CELA1_HUMAN, Q9UNI1
Function: Acts upon elastin
Catalytic activity: Hydrolysis of proteins, including elastin. Preferential cleavage: Ala- -Xaa

     Enzyme Numbers (IUBMB): EC 3.4.21.361 2 EC 3.4.212

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003824catalytic activity ----
GO:0004252serine-type endopeptidase activity IEA--
GO:0046872metal ion binding IEA--
     
CELA1 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for CELA1:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for CELA1 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CELA1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CELA1 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CELA1 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CELA1
3 QIAGEN miScript miRNA Assays for microRNAs that regulate CELA1:
hsa-miR-873 hsa-miR-24 hsa-miR-510
SwitchGear 3'UTR luciferase reporter plasmidCELA1 3' UTR sequence
Inhib. RNA
Products:
    
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CELA1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELA1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CELA1
Sirion Biotech Customized adenovirus for overexpression of CELA1

Clone
Products:
     
Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
OriGene clones in human, mouse for CELA1 (see all 8)
OriGene ORF clones in mouse, rat for CELA1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CELA1 (NM_001971)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CELA1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA1
Sirion Biotech Customized lentivirus for stable overexpression of CELA1 
                     Customized lentivirus expression plasmids for stable overexpression of CELA1 

Cell Line
Products:
     
GenScript Custom overexpressing Cell Line Services for CELA1
Search LifeMap BioReagents cell lines for CELA1
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELA1


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CELA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/7 Interacting proteins for CELA1 (Q9UNI13 ENSP000002936364) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
PI3P199573, ENSP000002439244I2D: score=2 STRING: ENSP00000243924
LPAP085193, ENSP000003213344I2D: score=1 STRING: ENSP00000321334
SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
A2MP010233, ENSP000003239294I2D: score=1 STRING: ENSP00000323929
CSN2P058143, ENSP000003410304I2D: score=1 STRING: ENSP00000341030
About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
GO:0006508proteolysis IEA--
GO:0006954inflammatory response IEA--
GO:0009791post-embryonic development IEA--
GO:0016055Wnt receptor signaling pathway IEA--

CELA1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
EMD Millipore small molecules for CELA1:
Small Molecule - inhibitor
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CELA1

1 HMDB Compound for CELA1    About this table
CompoundSynonyms CAS #PubMed Ids
CalciumCa (see all 2)7440-70-2--

10/17 DrugBank Compounds for CELA1 (see all 17)    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
(Tert-Butyloxycarbonyl)-Alanyl-Alanyl-Amine-- --target--17139284 17016423 10592235
2-[4-[[(S)-1-[[(S)-2-[[(Rs)-3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl]Aminocarbonyl]Pyrrolidin-1-Yl-]Carbonyl]-2-Methylpropyl]Aminocarbonyl]Benzoylamino]Acetic Acid-- --target--17139284 17016423 10592235
Dimethylformamide-- 68-12-2target--17139284 17016423 10592235
Mdl 101,146-- 149859-17-6target--17139284 17016423 10592235
ONO-6818-- 208848-19-5target--17139284 17016423 10592235
Para-Isopropylaniline-- --target--17139284 17016423 10592235
(2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE-- --target--10592235
(2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID-- --target--10592235
(2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID-- --target--10592235
(2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID-- --target--10592235

Search CenterWatch for drugs/clinical trials and news about CELA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CELA1 gene: 
NM_001971.5  

Unigene Cluster for CELA1:

Chymotrypsin-like elastase family, member 1
Hs.348395
Unigene Representative Sequence: NM_001971
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000293636(uc001ryi.1)
miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CELA1
3 QIAGEN miScript miRNA Assays for microRNAs that regulate CELA1:
hsa-miR-873 hsa-miR-24 hsa-miR-510
SwitchGear 3'UTR luciferase reporter plasmidCELA1 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for CELA1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELA1
Clone
Products:
     
OriGene clones in human, mouse for CELA1 (see all 8)
OriGene ORF clones in mouse, rat for CELA1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CELA1 (NM_001971)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CELA1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA1
Sirion Biotech Customized lentivirus for stable overexpression of CELA1 
                     Customized lentivirus expression plasmids for stable overexpression of CELA1 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CELA1
OriGene qSTAR qPCR primer pairs in human, mouse for CELA1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CELA1
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA1
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA1

Additional mRNA sequence: 

AF120493.1 BC069454.1 BC075091.2 

1 DOTS entry:

DT.100740828 

5 AceView cDNA sequences:

BC075091 AF120493 BC069454 NM_001971 BF667586 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CELA1 expression in normal human tissues (normalized intensities)      CELA1 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CELA1 Expression
About this image


CELA1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Pancreas (Endocrine System)    fully expand to see all 2 entries
         Duct Cells Pancreatic Ducts
         visceral organ/gut/foregut-midgut junction   
 
 Blood (Hematopoietic System)
         Proerythroblasts Hematopoietic Bone Marrow

See CELA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CELA1

SOURCE GeneReport for Unigene cluster: Hs.348395

UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1
Tissue specificity: Basal layers of epidermis (at protein level). Not expressed in the pancreas

    SABiosciences Custom PCR Arrays for CELA1
Primer
Products:
OriGene qPCR primer pairs and template standards for CELA1
OriGene qSTAR qPCR primer pairs in human, mouse for CELA1
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CELA1
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA1
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELA1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CELA1 gene from 5/13 species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cela11 , 5 chymotrypsin-like elastase family, member 11, 5 85.6(n)1
84.82(a)1
  15 (56.38 cM)5
1099011  NM_033612.21  NP_291090.21 
 1006744255 
chicken
(Gallus gallus)
Aves CELA11 chymotrypsin-like elastase family, member 1 70.33(n)
69.8(a)
  425200  NM_001103202.1  NP_001096672.1 
lizard
(Anolis carolinensis)
Reptilia CELA16
Uncharacterized protein
71(a)
1 ↔ 1
2(67695079-67706837)
African clawed frog
(Xenopus laevis)
Amphibia Xl.28652 Xenopus laevis transcribed sequence with weak similarity more 74.15(n)    BX849304.1 
zebrafish
(Danio rerio)
Actinopterygii wufb65e062 wufb65e06 76.72(n)   322570  CF265408.1 


ENSEMBL Gene Tree for CELA1 (if available)
TreeFam Gene Tree for CELA1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CELA1 gene
CTRL2  CTRC2  CELA2A2  CELA3B2  CTRB12  CELA3A2  CELA2B2  OVCH22  
CTRB22  OVCH12  
18/90 SIMAP similar genes for CELA1 using alignment to 1 protein entry:     CELA1_HUMAN(see all similar genes):
CELA2A    CELA3B    ELA2A    CELA3A    CELA2B    ELA2B
ELA3A    CTRC    CTRB1    CTRB2    CTRL    PRSS1
DKFZp586F0824    GZMK    DF    DKFZp779M0222    PRSS2    PRSS3

CELA1 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CELA1
PGOHUM00000234656


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/502 SNPs in CELA1 are shown (see all 502)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0362954
A breast cancer sample4--see VAR_0362952 G A mis40--------
rs710897931,2
C--48764998(+) ACACA-/TACACAT 1 -- int11Minor allele frequency- TA:0.00NA 2
rs178603781,2
C,F--51721905(-) TTAGAA/GGAAAT 1 -- ds50014Minor allele frequency- G:0.11NS WA NA EA 536
rs71381571,2
C,F,A,H--51721976(+) GAACCA/GGGGTG 1 -- ds500115Minor allele frequency- G:0.07NS NA WA CSA EA 796
rs1811801461,2
--51721987(+) GGGGAC/TGGTTT 1 -- ds50010--------
rs178603761,2
C,F--51722002(-) CCTTGA/CATCAT 1 -- ds50011Minor allele frequency- C:0.01NS 176
rs1906435971,2
--51722030(+) TACTAC/TATTTC 1 -- ds50010--------
rs1386180951,2
--51722084(+) TCACCA/GTAATG 1 -- ds50010--------
rs178603751,2
C,F--51722132(-) GGACCG/ATCTAG 1 -- ds50012Minor allele frequency- A:0.02NS CSA 150
rs1434265241,2
--51722147(+) TGGGGA/GTGATG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for CELA1 (51722227 - 51740463 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CELA1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv469377CNV Loss19166990
nsv832408CNV Gain17160897


Human Gene Mutation Database (HGMD): CELA1
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing CELA1
DNA2.0 Custom Variant and Variant Library Synthesis for CELA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 130120    OMIM disorders: --

9 diseases for CELA1:    About MalaCards
pancreatic steatorrhea    pancreatitis    hepatopulmonary syndrome    exocrine pancreatic insufficiency
steatorrhea    diarrhea    liver disease    cystic fibrosis
pancreatic cancer

6 diseases from the University of Copenhagen DISEASES database for CELA1:
Exocrine pancreatic insufficiency     Pancreatitis     Steatorrhea     Pancreatic cancer
Cystic fibrosis     Pancreatic steatorrhea

CELA1 for disorders           About GeneDecksing

Genetic Association Database (GAD): CELA1
Human Genome Epidemiology (HuGE) Navigator: CELA1 (5 documents)

Export disorders for CELA1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CELA1 gene, integrated from 9 sources (see all 26):
(articles sorted by number of sources associating them with CELA1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
  2. Genetic Risk Factors for Hepatopulmonary Syndrome in Patients With Advanced Liver Disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (2010)
  3. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  5. Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism. (PubMed id 10620133)1, 2 Talas U.... Kelsell D.P. (2000)
  6. Fecal elastase-1 is useful in the detection of steator rhea in patients with pancreatic diseases but not after pancreatic resection. (PubMed id 23395568)1 Benini L....Frulloni L. (2013)
  7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
  8. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
  9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
  10. Drugs, their targets and the nature and number of dru g targets. (PubMed id 17016423)7 Imming P....Meyer A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 1990 HGNC: 3308 AceView: ELA1 Ensembl:ENSG00000139610 euGenes: HUgn1990
ECgene: CELA1 H-InvDB: CELA1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CELA1 Pharmacogenomics, SNPs, Pathways
NIEHS-SNPshttp://egp.gs.washington.edu/data/ela1/
Wikipedia http://en.wikipedia.org/wiki/Elastase

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CELA1 gene:
Search GeneIP for patents involving CELA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 EMD Millipore small molecules (inhibitor) for CELA1
 Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
 Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
 Browse Purified and Recombinant Proteins at EMD Millipore
 Browse Kits and Assays available from EMD Millipore
 Browse for Gene Knock-down Tools from EMD Millipore
 
 EMD Millipore Custom Antibody & Bulk Services
 EMD Millipore Preclinical / Clinical Development Services
 EMD Millipore Immunoassay Services
 EMD Millipore Target Screening & Profiling Services

  
 Browse Antibodies   Browse Cell Culture Products  
 Browse ELISAs   Browse Flow Cytometry Kits  
 Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
 Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
 Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
 Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
 Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
 Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
 Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
 Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
 Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CELA1  
 OriGene qPCR primer pairs and template standards for CELA1   OriGene Protein Over-expression Lysate for CELA1  
 OriGene Custom Mass Spec   OriGene clones in human, mouse for CELA1  
 OriGene qSTAR qPCR primer pairs in human, mouse for CELA1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
 OriGene ORF clones in mouse, rat for CELA1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
 OriGene Custom Antibody Services for CELA1   OriGene Custom Protein Services for CELA1  

 
 
 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CELA1
 QIAGEN SeqTarget long-range PCR primers for resequencing CELA1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CELA1
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CELA1
 QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CELA1
 QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CELA1
 GenScript Custom Purified and Recombinant Proteins Services for CELA1 GenScript cDNA clones with any tag delivered in your preferred vector for CELA1
 GenScript Custom Assay Services for CELA1 GenScript Custom Superior Antibodies Services for CELA1
 GenScript Custom overexpressing Cell Line Services for CELA1 CloneReady with Over 120,000 Genes
 Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
 Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
 Custom Peptide Services
 Search for Antibodies & Assays

 Regulatory tfbs in CELA1 promoter
 Search Chromatin IP Primers for CELA1
 RT2 qPCR Primer Assay in human, mouse, rat CELA1
 Search GNC Networks for CELA1
 SABiosciences Custom PCR Arrays for CELA1
 Search Tocris compounds for CELA1
 Browse Sino Biological Proteins and Antibodies
 Browse Sino Biological Cell Lysates
 Browse Sino Biological cDNA Clones
 4000+ Proteins
 Search Sino Biological for antibodies, proteins & pathways
 Protein Production Services
 Transfection Reagents
 Protein A/G/L resins
 Isotyping reagents
 Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
 Novus Tissue Slides
 CELA1 antibodies
 CELA1 proteins
 CELA1 lysates
 Antibodies for CELA1
 See all of Abcam's Antibodies, Kits and Proteins for CELA1
 Custom Antibody / Protein Production Service
 Bulk Purchasing
 Advantages of Rabbit Monoclonal antibodies
 Abcam protocols and scientific support
 Browse ProSpec Recombinant Proteins




 Browse Proteins at Cloud-Clone Corp.
 Browse Antibodies at Cloud-Clone Corp.
 Browse ELISAs at Cloud-Clone Corp.
 Browse CLIAs at Cloud-Clone Corp.
 Search LifeMap BioReagents cell lines for CELA1
 Gene Synthesis
 Protein Engineering
 Variant Library Synthesis
 Codon Optimization
 Protein Production and Purification
 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CELA1
 SwitchGear 3'UTR luciferase reporter plasmids for CELA1
 SwitchGear Promoter luciferase reporter plasmids for CELA1
 Search ThermoFisher Antibodies for CELA1
 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CELA1
 inGenious Targeting Laboratory - Custom generated mouse model solutions for CELA1
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CELA1
Customized:
 lentivirus for stable overexpression of CELA1
 lentivirus expression plasmids for stable overexpression of CELA1
 adenovirus for overexpression of CELA1
 LSBio Antibodies in human, mouse, rat for CELA1
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

View Random Gene

Category
(GIFtS: 73)
transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      CELA1 gene at Home site.
hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4