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CELA1 Gene

protein-coding   GIFtS: 54
GCID: GC12M051723

Chymotrypsin-Like Elastase Family, Member 1

(Previous names: elastase 1, pancreatic)
(Previous symbol: ELA1)
  See CELA1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chymotrypsin-Like Elastase Family, Member 11 2     Chymotrypsin-Like Elastase Family Member 12
ELA11 2 3 5     elastase-12
Elastase 1, Pancreatic1 2     Elastase-13
Pancreatic Elastase 12 3     EC 3.4.218
EC 3.4.21.363 8     

External Ids:    HGNC: 33081   Entrez Gene: 19902   Ensembl: ENSG000001396107   OMIM: 1301205   UniProtKB: Q9UNI13   

Export aliases for CELA1 gene to outside databases

Previous GC identifers: GC12M050012 GC12M048755


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CELA1 Gene:
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have
six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other
elastases, pancreatic elastase 1 is not expressed in the pancreas. To date, elastase 1 expression has only been
detected in skin keratinocytes. Clinical literature that describes human elastase 1 activity in the pancreas or
fecal material is actually referring to chymotrypsin-like elastase family, member 3B. (provided by RefSeq, May
2009)

GeneCards Summary for CELA1 Gene:
CELA1 (chymotrypsin-like elastase family, member 1) is a protein-coding gene. Diseases associated with CELA1 include pancreatic steatorrhea, and steatorrhea. GO annotations related to this gene include serine-type endopeptidase activity. An important paralog of this gene is CTRL.

UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1
Function: Acts upon elastin

Gene Wiki entry for CELA1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CELA1 gene promoter:
         AML1a   Tal-1   Pax-6   CBF-C   E47   PPAR-gamma1   CBF-A   CBF-B   PPAR-gamma2   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCELA1 promoter sequence
   Search Chromatin IP Primers for CELA1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CELA1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13

CELA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CELA1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M051723:  view genomic region     (about GC identifiers)

Start:
51,722,227 bp from pter      End:
51,740,463 bp from pter
Size:
18,237 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1 (See protein sequence)
Recommended Name: Chymotrypsin-like elastase family member 1 precursor  
Size: 258 amino acids; 27798 Da
Cofactor: Binds 1 calcium ion per subunit (By similarity)
Caution: In spite of its original name "Pancreatic elastase 1", CELA1 is not detected in the pancreas. Elastase
activity described in the pancreas may be in fact due to CELA2A (PubMed:10620133)
Sequence caution: Sequence=AAV88109.1; Type=Erroneous gene model prediction;
Secondary accessions: Q5MLF0 Q6DJT0 Q6ISM6

Explore the universe of human proteins at neXtProt for CELA1: NX_Q9UNI1

Explore proteomics data for CELA1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn79, Asn233
  • Selected DME Specific Peptides for CELA1 (Q9UNI1) (see all 11)
     CYITGWG  VMTAAHC  GDSGGPL  YVQLGVLP 


    See CELA1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001962.3  
    ENSEMBL proteins: 
     ENSP00000293636  

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    Browse Proteins at Cloud-Clone Corp.

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR001314 Peptidase_S1A
     IPR001254 Peptidase_S1
     IPR018114 Peptidase_S1_AS
     IPR009003 Trypsin-like_Pept_dom

    Graphical View of Domain Structure for InterPro Entry Q9UNI1

    ProtoNet protein and cluster: Q9UNI1

    2 Blocks protein domains:
    IPB001254 Serine protease
    IPB001314 Chymotrypsin serine protease family (S1) signature


    UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1
    Similarity: Belongs to the peptidase S1 family. Elastase subfamily
    Similarity: Contains 1 peptidase S1 domain


    Find genes that share domains with CELA1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CELA1_HUMAN, Q9UNI1
    Function: Acts upon elastin
    Catalytic activity: Hydrolysis of proteins, including elastin. Preferential cleavage: Ala- -Xaa

         Enzyme Numbers (IUBMB): EC 3.4.21.361 2 EC 3.4.212

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004252serine-type endopeptidase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with CELA1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CELA1:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CELA1
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    3 qRT-PCR Assays for microRNAs that regulate CELA1:
    hsa-miR-873 hsa-miR-24 hsa-miR-510
    SwitchGear 3'UTR luciferase reporter plasmidCELA1 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CELA1_HUMAN, Q9UNI1: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    nucleus2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    Find genes that share ontologies with CELA1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CELA1
    Interactions:

        Search GeneGlobe Interaction Network for CELA1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CELA1 (Q9UNI13 ENSP000002936364) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PI3P199573, ENSP000002439244I2D: score=2 STRING: ENSP00000243924
    LPAP085193, ENSP000003213344I2D: score=1 STRING: ENSP00000321334
    SERPINA1P010093, ENSP000003480684I2D: score=1 STRING: ENSP00000348068
    A2MP010233, ENSP000003239294I2D: score=1 STRING: ENSP00000323929
    CSN2P058143, ENSP000003410304I2D: score=1 STRING: ENSP00000341030
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0006508proteolysis ----
    GO:0006954inflammatory response IEA--
    GO:0009791post-embryonic development IEA--
    GO:0016055Wnt signaling pathway IEA--

    Find genes that share ontologies with CELA1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CELA1

    1 HMDB Compound for CELA1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected DrugBank Compounds for CELA1 (see all 17)    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (Tert-Butyloxycarbonyl)-Alanyl-Alanyl-Amine-- --target--17139284 17016423 10592235
    2-[4-[[(S)-1-[[(S)-2-[[(Rs)-3,3,3-Trifluoro-1-Isopropyl-2-Oxopropyl]Aminocarbonyl]Pyrrolidin-1-Yl-]Carbonyl]-2-Methylpropyl]Aminocarbonyl]Benzoylamino]Acetic Acid-- --target--17139284 17016423 10592235
    Dimethylformamide-- 68-12-2target--17139284 17016423 10592235
    Mdl 101,146-- 149859-17-6target--17139284 17016423 10592235
    ONO-6818-- 208848-19-5target--17139284 17016423 10592235
    Para-Isopropylaniline-- --target--17139284 17016423 10592235
    (2-BROMOETHYL)(2-'FORMYL-4'-AMINOPHENYL) ACETATE-- --target--10592235
    (2R)-3-{[(BENZYLAMINO)CARBONYL]AMINO}-2-HYDROXYPROPANOIC ACID-- --target--10592235
    (2S,3S)-3-FORMYL-2-({[(4-METHYLPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID-- --target--10592235
    (2S,3S)-3-FORMYL-2-({[(4-NITROPHENYL)SULFONYL]AMINO}METHYL)PENTANOIC ACID-- --target--10592235



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CELA1 gene: 
    NM_001971.5  

    Unigene Cluster for CELA1:

    Chymotrypsin-like elastase family, member 1
    Hs.348395
    Unigene Representative Sequence: NM_001971
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000293636(uc001ryi.1)
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidCELA1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CELA1
      QuantiFast Probe-based Assays in human, mouse, rat CELA1

    Additional mRNA sequence: 

    AF120493.1 BC069454.1 BC075091.2 

    1 DOTS entry:

    DT.100740828 

    5 AceView cDNA sequences:

    BC075091 AF120493 BC069454 NM_001971 BF667586 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CELA1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CELA1 Expression
    About this image


    CELA1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             Islets of Langerhans
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    CELA1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CELA1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.348395

    UniProtKB/Swiss-Prot: CELA1_HUMAN, Q9UNI1
    Tissue specificity: Basal layers of epidermis (at protein level). Not expressed in the pancreas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CELA1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cela11 , 5 chymotrypsin-like elastase family, member 11, 5 85.6(n)1
    84.82(a)1
      15 (56.38 cM)5
    1099011  NM_033612.21  NP_291090.21 
     1006744255 
    chicken
    (Gallus gallus)
    Aves CELA11 chymotrypsin-like elastase family, member 1 70.33(n)
    69.8(a)
      425200  NM_001103202.1  NP_001096672.1 
    lizard
    (Anolis carolinensis)
    Reptilia CELA16
    chymotrypsin-like elastase family, member 1
    71(a)
    1 ↔ 1
    2(67695079-67706837)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.28652 Xenopus laevis transcribed sequence with weak similarity more 74.15(n)    BX849304.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb65e062 wufb65e06 76.72(n)   322570  CF265408.1 


    ENSEMBL Gene Tree for CELA1 (if available)
    TreeFam Gene Tree for CELA1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CELA1 gene
    CTRL2  CTRC2  CELA2A2  CELA3B2  CTRB12  CELA3A2  CELA2B2  CTRB22  
    Selected SIMAP similar genes for CELA1 using alignment to 1 protein entry:     CELA1_HUMAN(see all similar genes):
    CELA2A    CELA3B    ELA2A    CELA3A    CELA2B    ELA2B
    ELA3A    CTRC    CTRB1    CTRB2    CTRL    PRSS1
    DKFZp586F0824    GZMK    DF    DKFZp779M0222    PRSS2    PRSS3

    Find genes that share paralogs with CELA1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CELA1
    PGOHUM00000234656


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CELA1 (see all 502)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0362954
    A breast cancer sample4--see VAR_0362952 G A mis40--------
    rs710897931,2
    C--48764998(+) ACACA-/TACACAT 1 -- int11Minor allele frequency- TA:0.00NA 2
    rs178603781,2
    C,F--51721905(-) TTAGAA/GGAAAT 1 -- ds50014Minor allele frequency- G:0.11NS WA NA EA 536
    rs71381571,2
    C,F,A,H--51721976(+) GAACCA/GGGGTG 1 -- ds500115Minor allele frequency- G:0.07NS NA WA CSA EA 796
    rs1811801461,2
    --51721987(+) GGGGAC/TGGTTT 1 -- ds50010--------
    rs178603761,2
    C,F--51722002(-) CCTTGA/CATCAT 1 -- ds50011Minor allele frequency- C:0.01NS 176
    rs1906435971,2
    --51722030(+) TACTAC/TATTTC 1 -- ds50010--------
    rs1386180951,2
    --51722084(+) TCACCA/GTAATG 1 -- ds50010--------
    rs178603751,2
    C,F--51722132(-) GGACCG/ATCTAG 1 -- ds50012Minor allele frequency- A:0.02NS CSA 150
    rs1434265241,2
    --51722147(+) TGGGGA/GTGATG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CELA1 (51722227 - 51740463 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CELA1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv469377CNV Loss19166990
    nsv832408CNV Gain17160897

    Human Gene Mutation Database (HGMD): CELA1
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 130120    OMIM disorders: --

    4 diseases for CELA1:    
    About MalaCards
    pancreatic steatorrhea    steatorrhea    hepatopulmonary syndrome    exocrine pancreatic insufficiency

    6 diseases from the University of Copenhagen DISEASES database for CELA1:
    Exocrine pancreatic insufficiency     Pancreatitis     Steatorrhea     Pancreatic cancer
    Cystic fibrosis     Pancreatic steatorrhea

    Find genes that share disorders with CELA1           About GenesLikeMe

    Genetic Association Database (GAD): CELA1
    Human Genome Epidemiology (HuGE) Navigator: CELA1 (5 documents)

    Export disorders for CELA1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CELA1 gene, integrated from 10 sources (see all 26):
    (articles sorted by number of sources associating them with CELA1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Genetic risk factors for hepatopulmonary syndrome in patients with advanced liver disease. (PubMed id 20346360)1, 4 Roberts K.E....Fallon M.B. (Gastroenterology 2010)
    3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Human elastase 1: evidence for expression in the skin and the identification of a frequent frameshift polymorphism. (PubMed id 10620133)1, 2 Talas U.... Kelsell D.P. (J. Invest. Dermatol. 2000)
    6. Fecal elastase-1 is useful in the detection of steatorrhea in patients with pancreatic diseases but not after pancreatic resection. (PubMed id 23395568)1 Benini L....Frulloni L. (Pancreatology 2013)
    7. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    8. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
    9. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)
    10. Drugs, their targets and the nature and number of drug targets. (PubMed id 17016423)7 Imming P....Meyer A. (Nat Rev Drug Discov 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1990 HGNC: 3308 AceView: ELA1 Ensembl:ENSG00000139610 euGenes: HUgn1990
    ECgene: CELA1 H-InvDB: CELA1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CELA1 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ela1/
    Wikipedia http://en.wikipedia.org/wiki/Elastase

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CELA1 gene:
    Search GeneIP for patents involving CELA1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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