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Aliases for CEBPZ Gene

Aliases for CEBPZ Gene

  • CCAAT/Enhancer Binding Protein Zeta 2 3 5
  • CCAAT/Enhancer Binding Protein (C/EBP), Zeta 2 3
  • CCAAT-Box-Binding Transcription Factor 3 4
  • CBF2 3 4
  • CBF 3 4
  • CCAAT/Enhancer Binding Proteincebp* Family Zeta 2
  • CCAAT/Enhancer Binding Protein Cebp Family Zeta 3
  • CCAAT/Enhancer-Binding Protein Zeta 3
  • CCAAT-Binding Factor 4
  • HSP-CBF 3
  • NOC1 3

External Ids for CEBPZ Gene

Previous GeneCards Identifiers for CEBPZ Gene

  • GC02M037403
  • GC02M037340
  • GC02M037428
  • GC02M037168

Summaries for CEBPZ Gene

Entrez Gene Summary for CEBPZ Gene

  • This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]

GeneCards Summary for CEBPZ Gene

CEBPZ (CCAAT/Enhancer Binding Protein Zeta) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Direct p53 effectors. GO annotations related to this gene include poly(A) RNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CEBPZ Gene

  • Stimulates transcription from the HSP70 promoter.

Gene Wiki entry for CEBPZ Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPZ Gene

Genomics for CEBPZ Gene

Regulatory Elements for CEBPZ Gene

Enhancers for CEBPZ Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G037195 1.3 ENCODE dbSUPER 20.6 +33.3 33324 5.0 PKNOX1 FOXA2 CREB3L1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 ZNF766 CEBPZOS CEBPZ NDUFAF7 EIF2AK2 SULT6B1 ENSG00000272054
GH02G038095 1.8 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -865.6 -865594 4.6 PKNOX1 FOXA2 ARNT FEZF1 ZBTB7B GLIS2 FOS KLF7 SP3 TSHZ1 CYP1B1 CYP1B1-AS1 ARHGEF33 CEBPZ RMDN2-AS1 CDC42EP3
GH02G037322 1.3 ENCODE dbSUPER 17.6 -93.5 -93454 4.3 PKNOX1 FOXA2 CREB3L1 AGO1 ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 CEBPZ PRKD3 NDUFAF7 CEBPZOS LOC101929542 GC02M037332 RNU6-939P
GH02G037870 1.4 Ensembl ENCODE dbSUPER 13.6 -639.6 -639593 2.6 HDGF PKNOX1 FOS IKZF2 CREM EGR2 ZBTB11 CEBPB ZNF426 JUNB LINC00211 CEBPZ LOC105374464 CDC42EP3 LOC344382
GH02G037204 1 ENCODE dbSUPER 18.8 +25.8 25780 3.6 CBX3 FOXA2 TEAD4 MAX CHD7 POLR2H HDAC2 POLR2A ADNP POU5F1 CEBPZOS CEBPZ NDUFAF7 EIF2AK2 ENSG00000272054 SULT6B1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEBPZ on UCSC Golden Path with GeneCards custom track

Promoters for CEBPZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000115327 513 2401 HDGF PKNOX1 MLX ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YY1 FOS

Genomic Location for CEBPZ Gene

Chromosome:
2
Start:
37,201,612 bp from pter
End:
37,231,713 bp from pter
Size:
30,102 bases
Orientation:
Minus strand

Genomic View for CEBPZ Gene

Genes around CEBPZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPZ Gene

Proteins for CEBPZ Gene

  • Protein details for CEBPZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03701-CEBPZ_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein zeta
    Protein Accession:
    Q03701
    Secondary Accessions:
    • Q8NE75

    Protein attributes for CEBPZ Gene

    Size:
    1054 amino acids
    Molecular mass:
    120974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA51924.1; Type=Frameshift; Positions=998; Evidence={ECO:0000305};

neXtProt entry for CEBPZ Gene

Post-translational modifications for CEBPZ Gene

  • Ubiquitination at posLast=314314
  • Modification sites at PhosphoSitePlus

Other Protein References for CEBPZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPZ Gene

Domains & Families for CEBPZ Gene

Gene Families for CEBPZ Gene

Protein Domains for CEBPZ Gene

Suggested Antigen Peptide Sequences for CEBPZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q03701

UniProtKB/Swiss-Prot:

CEBPZ_HUMAN :
  • Belongs to the CBF/MAK21 family.
Family:
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with CEBPZ: view

Function for CEBPZ Gene

Molecular function for CEBPZ Gene

UniProtKB/Swiss-Prot Function:
Stimulates transcription from the HSP70 promoter.

Gene Ontology (GO) - Molecular Function for CEBPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 2247079
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 2247079
GO:0003677 DNA binding TAS 2247079
GO:0003723 RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CEBPZ: view
genes like me logo Genes that share phenotypes with CEBPZ: view

Animal Model Products

CRISPR Products

miRNA for CEBPZ Gene

miRTarBase miRNAs that target CEBPZ

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEBPZ Gene

Localization for CEBPZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPZ Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEBPZ gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CEBPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS --
genes like me logo Genes that share ontologies with CEBPZ: view

Pathways & Interactions for CEBPZ Gene

genes like me logo Genes that share pathways with CEBPZ: view

Pathways by source for CEBPZ Gene

Gene Ontology (GO) - Biological Process for CEBPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 2247079
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IDA 2247079
genes like me logo Genes that share ontologies with CEBPZ: view

No data available for SIGNOR curated interactions for CEBPZ Gene

Drugs & Compounds for CEBPZ Gene

(1) Drugs for CEBPZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CEBPZ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEBPZ: view

Transcripts for CEBPZ Gene

mRNA/cDNA for CEBPZ Gene

Unigene Clusters for CEBPZ Gene

CCAAT/enhancer binding protein (C/EBP), zeta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPZ Gene

No ASD Table

Relevant External Links for CEBPZ Gene

GeneLoc Exon Structure for
CEBPZ
ECgene alternative splicing isoforms for
CEBPZ

Expression for CEBPZ Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEBPZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPZ Gene

This gene is overexpressed in Testis (10.4), CD8 Tcells (7.8), Fetal testis (7.3), Fetal ovary (6.7), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEBPZ Gene



Protein tissue co-expression partners for CEBPZ Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEBPZ Gene:

CEBPZ

SOURCE GeneReport for Unigene cluster for CEBPZ Gene:

Hs.135406

Evidence on tissue expression from TISSUES for CEBPZ Gene

  • Liver(4.3)
  • Nervous system(3.5)
  • Blood(2.2)
genes like me logo Genes that share expression patterns with CEBPZ: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPZ Gene

Orthologs for CEBPZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CEBPZ Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEBPZ 34 35
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia CEBPZ 34 35
  • 89.95 (n)
cow
(Bos Taurus)
Mammalia CEBPZ 34 35
  • 87.85 (n)
mouse
(Mus musculus)
Mammalia Cebpz 34 16 35
  • 83.09 (n)
rat
(Rattus norvegicus)
Mammalia Cebpz 34
  • 82.15 (n)
oppossum
(Monodelphis domestica)
Mammalia CEBPZ 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPZ 35
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEBPZ 34 35
  • 68.87 (n)
lizard
(Anolis carolinensis)
Reptilia CEBPZ 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpz 34
  • 65.23 (n)
Str.7416 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10705 34
zebrafish
(Danio rerio)
Actinopterygii cebpz 34 35
  • 62.24 (n)
wufi26d06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6779 34
fruit fly
(Drosophila melanogaster)
Insecta CG7839 35
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F23B12.7 34
  • 47.32 (n)
F23B12.7 35
  • 30 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK21 34 35 37
  • 48.93 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12519g 34
  • 46.81 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER174W 34
  • 41.3 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F10.09c 34
  • 50.24 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU09894 34
  • 46.02 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 30 (a)
OneToOne
Species where no ortholog for CEBPZ was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPZ Gene

ENSEMBL:
Gene Tree for CEBPZ (if available)
TreeFam:
Gene Tree for CEBPZ (if available)

Paralogs for CEBPZ Gene

No data available for Paralogs for CEBPZ Gene

Variants for CEBPZ Gene

Sequence variations from dbSNP and Humsavar for CEBPZ Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs756442818 Likely benign 37,231,724(+) TGAGG(A/T)CAGGT nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs386352290 Uncertain significance 37,228,554(-) CTGTA(G/T)CAGCA reference, stop-gained
rs73927405 Uncertain significance 37,231,728(+) GTCAG(A/G)TTTGG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs764894035 Uncertain significance 37,231,706(+) TCAGC(A/G)TGAGT nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs145277736 Benign 37,231,669(+) GCCCC(-/A)GCTCC nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CEBPZ Gene

Variant ID Type Subtype PubMed ID
nsv2684 CNV insertion 18451855

Variation tolerance for CEBPZ Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEBPZ Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEBPZ

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPZ Gene

Disorders for CEBPZ Gene

Relevant External Links for CEBPZ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEBPZ

No disorders were found for CEBPZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEBPZ Gene

Publications for CEBPZ Gene

  1. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. (PMID: 2247079) Lum L. … Wu B. (Mol. Cell. Biol. 1990) 2 3 4 22 64
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression. (PMID: 12534345) Uramoto H. … Kohno K. (Biochem. J. 2003) 2 3 64

Products for CEBPZ Gene

Sources for CEBPZ Gene

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