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Aliases for CEBPZ Gene

Aliases for CEBPZ Gene

  • CCAAT/Enhancer Binding Protein Zeta 2 3
  • CCAAT/Enhancer Binding Protein (C/EBP), Zeta 2 3 5
  • CCAAT/Enhancer Binding Proteincebp* Family Zeta 2 3
  • CCAAT-Box-Binding Transcription Factor 3 4
  • CCAAT-Binding Factor 3 4
  • CBF2 3 4
  • CBF 3 4
  • HSP-CBF 3
  • NOC1 3

External Ids for CEBPZ Gene

Previous GeneCards Identifiers for CEBPZ Gene

  • GC02M037403
  • GC02M037340
  • GC02M037428
  • GC02M037168

Summaries for CEBPZ Gene

GeneCards Summary for CEBPZ Gene

CEBPZ (CCAAT/Enhancer Binding Protein Zeta) is a Protein Coding gene. Among its related pathways are Gastric cancer network 2 and Direct p53 effectors. GO annotations related to this gene include poly(A) RNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding.

UniProtKB/Swiss-Prot for CEBPZ Gene

  • Stimulates transcription from the HSP70 promoter.

Gene Wiki entry for CEBPZ Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPZ Gene

Genomics for CEBPZ Gene

Regulatory Elements for CEBPZ Gene

Enhancers for CEBPZ Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEBPZ on UCSC Golden Path with GeneCards custom track

Promoters for CEBPZ Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEBPZ on UCSC Golden Path with GeneCards custom track

Genomic Location for CEBPZ Gene

Chromosome:
2
Start:
37,201,612 bp from pter
End:
37,231,713 bp from pter
Size:
30,102 bases
Orientation:
Minus strand

Genomic View for CEBPZ Gene

Genes around CEBPZ on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPZ Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPZ Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPZ Gene

Proteins for CEBPZ Gene

  • Protein details for CEBPZ Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03701-CEBPZ_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein zeta
    Protein Accession:
    Q03701
    Secondary Accessions:
    • Q8NE75

    Protein attributes for CEBPZ Gene

    Size:
    1054 amino acids
    Molecular mass:
    120974 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA51924.1; Type=Frameshift; Positions=998; Evidence={ECO:0000305};

neXtProt entry for CEBPZ Gene

Proteomics data for CEBPZ Gene at MOPED

Post-translational modifications for CEBPZ Gene

  • Ubiquitination at Lys 314
  • Modification sites at PhosphoSitePlus

Other Protein References for CEBPZ Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPZ Gene

Domains & Families for CEBPZ Gene

Gene Families for CEBPZ Gene

Protein Domains for CEBPZ Gene

Suggested Antigen Peptide Sequences for CEBPZ Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q03701

UniProtKB/Swiss-Prot:

CEBPZ_HUMAN :
  • Belongs to the CBF/MAK21 family.
Family:
  • Belongs to the CBF/MAK21 family.
genes like me logo Genes that share domains with CEBPZ: view

Function for CEBPZ Gene

Molecular function for CEBPZ Gene

UniProtKB/Swiss-Prot Function:
Stimulates transcription from the HSP70 promoter.

Gene Ontology (GO) - Molecular Function for CEBPZ Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 2247079
GO:0003677 DNA binding TAS 2247079
GO:0005488 binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with CEBPZ: view
genes like me logo Genes that share phenotypes with CEBPZ: view

Animal Model Products

miRNA for CEBPZ Gene

miRTarBase miRNAs that target CEBPZ

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEBPZ Gene

Localization for CEBPZ Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPZ Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEBPZ Gene COMPARTMENTS Subcellular localization image for CEBPZ gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CEBPZ Gene

Pathways & Interactions for CEBPZ Gene

genes like me logo Genes that share pathways with CEBPZ: view

Pathways by source for CEBPZ Gene

2 BioSystems pathways for CEBPZ Gene

Gene Ontology (GO) - Biological Process for CEBPZ Gene

None

No data available for SIGNOR curated interactions for CEBPZ Gene

Drugs & Compounds for CEBPZ Gene

(1) Drugs for CEBPZ Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(3) Additional Compounds for CEBPZ Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEBPZ: view

Transcripts for CEBPZ Gene

Unigene Clusters for CEBPZ Gene

CCAAT/enhancer binding protein (C/EBP), zeta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPZ Gene

No ASD Table

Relevant External Links for CEBPZ Gene

GeneLoc Exon Structure for
CEBPZ
ECgene alternative splicing isoforms for
CEBPZ

Expression for CEBPZ Gene

mRNA expression in normal human tissues for CEBPZ Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPZ Gene

This gene is overexpressed in Testis (10.4), CD8 Tcells (7.8), Fetal testis (7.3), Fetal ovary (6.7), and Peripheral blood mononuclear cells (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEBPZ Gene



SOURCE GeneReport for Unigene cluster for CEBPZ Gene Hs.135406

genes like me logo Genes that share expression patterns with CEBPZ: view

Protein tissue co-expression partners for CEBPZ Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEBPZ Gene

Orthologs for CEBPZ Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CEBPZ Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEBPZ 35
  • 87.85 (n)
  • 85.31 (a)
CEBPZ 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEBPZ 35
  • 89.95 (n)
  • 88.65 (a)
CEBPZ 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cebpz 35
  • 83.09 (n)
  • 82.2 (a)
Cebpz 16
Cebpz 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEBPZ 35
  • 99.37 (n)
  • 98.67 (a)
CEBPZ 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cebpz 35
  • 82.15 (n)
  • 82.21 (a)
oppossum
(Monodelphis domestica)
Mammalia CEBPZ 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPZ 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CEBPZ 35
  • 68.87 (n)
  • 67.21 (a)
CEBPZ 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEBPZ 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpz 35
  • 65.23 (n)
  • 62.82 (a)
Str.7416 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.10705 35
zebrafish
(Danio rerio)
Actinopterygii cebpz 35
  • 62.24 (n)
  • 60.83 (a)
wufi26d06 35
cebpz 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6779 35
fruit fly
(Drosophila melanogaster)
Insecta CG7839 36
  • 25 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_F23B12.7 35
  • 47.32 (n)
  • 36.81 (a)
F23B12.7 36
  • 30 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER174W 35
  • 41.3 (n)
  • 33.29 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12519g 35
  • 46.81 (n)
  • 35.19 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MAK21 35
  • 48.93 (n)
  • 36.75 (a)
MAK21 36
  • 27 (a)
OneToOne
MAK21 38
bread mold
(Neurospora crassa)
Ascomycetes NCU09894 35
  • 46.02 (n)
  • 40.15 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC4F10.09c 35
  • 50.24 (n)
  • 39.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
OneToOne
Species with no ortholog for CEBPZ:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPZ Gene

ENSEMBL:
Gene Tree for CEBPZ (if available)
TreeFam:
Gene Tree for CEBPZ (if available)

Paralogs for CEBPZ Gene

No data available for Paralogs for CEBPZ Gene

Variants for CEBPZ Gene

Sequence variations from dbSNP and Humsavar for CEBPZ Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs2098386 - 37,228,889(-) CCTTA(A/G)TTGAA reference, missense
VAR_031399 -
rs17020328 - 37,228,285(+) TCAGC(C/T)TCCGA reference, missense
rs3180252 - 37,222,529(-) TGCAA(A/G)TGATG reference, missense
rs1803251 -- 37,227,855(-) TTAAA(C/T)CAAAT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CEBPZ Gene

Variant ID Type Subtype PubMed ID
nsv2684 CNV Insertion 18451855

Variation tolerance for CEBPZ Gene

Residual Variation Intolerance Score: 36.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.39; 77.06% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEBPZ Gene

Disorders for CEBPZ Gene

Relevant External Links for CEBPZ

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEBPZ

No disorders were found for CEBPZ Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEBPZ Gene

Publications for CEBPZ Gene

  1. A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. (PMID: 2247079) Lum L. … Wu B. (Mol. Cell. Biol. 1990) 2 3 4 23 67
  2. Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression. (PMID: 12534345) Uramoto H. … Kohno K. (Biochem. J. 2003) 2 3
  3. Cloning and characterization of mouse CCAAT binding factor. (PMID: 8604343) Hoeppner M.A. … Wu B. (Nucleic Acids Res. 1996) 3 23
  4. Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression. (PMID: 25693804) Diner B.A. … Cristea I.M. (Mol. Cell Proteomics 2015) 3
  5. FBXW7 modulates cellular stress response and metastatic potential through a88HSF1 post-translational modification. (PMID: 25720964) Kourtis N. … Aifantis I. (Nat. Cell Biol. 2015) 3

Products for CEBPZ Gene

Sources for CEBPZ Gene

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