Aliases for CEBPZ Gene
Aliases for CEBPZ Gene
External Ids for CEBPZ Gene
- HGNC: 24218
- Entrez Gene: 10153
- Ensembl: ENSG00000115816
- OMIM: 612828
- UniProtKB: Q03701
Previous GeneCards Identifiers for CEBPZ Gene
- GC02M037403
- GC02M037340
- GC02M037428
- GC02M037168
Summaries for CEBPZ Gene
-
This gene belongs to the CEBP family. The encoded protein plays a role in cellular response to environmental stimuli through a transcriptional process that involves heat shock factors, conserved DNA elements (heat shock elements or HSEs) and CCAAT boxes. The protein acts as a DNA-binding transcriptional activator and regulates the heat-shock protein 70 (HSP70) promoter in a CCAAT-dependent manner. The protein is also involved in cell growth and differentiation, particularly, hematopoietic differentiation. Methylation of the promoter of this gene or mutations within the gene may be correlated with occurance of acute myeloid leukemia (AML). [provided by RefSeq, Jun 2016]
GeneCards Summary for CEBPZ Gene
CEBPZ (CCAAT/Enhancer Binding Protein Zeta) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Direct p53 effectors. GO annotations related to this gene include poly(A) RNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding.
UniProtKB/Swiss-Prot for CEBPZ Gene
-
Stimulates transcription from the HSP70 promoter.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPZ Gene
Genomics for CEBPZ Gene
Regulatory Elements for CEBPZ Gene
Regulatory Element Products
Genomic Location for CEBPZ Gene
- Chromosome:
- 2
- Start:
- 37,201,612 bp from pter
- End:
- 37,231,713 bp from pter
- Size:
- 30,102 bases
- Orientation:
- Minus strand
Genomic View for CEBPZ Gene
- Cytogenetic band:
-
- 2p22.2 by Ensembl
- 2p22.2 by Entrez Gene
- 2p22.2 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CEBPZ Gene
Proteins for CEBPZ Gene
-
Protein details for CEBPZ Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q03701-CEBPZ_HUMAN
- Recommended name:
- CCAAT/enhancer-binding protein zeta
- Protein Accession:
- Q03701
- Q8NE75
Protein attributes for CEBPZ Gene
- Size:
- 1054 amino acids
- Molecular mass:
- 120974 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAA51924.1; Type=Frameshift; Positions=998; Evidence={ECO:0000305};
Protein Expression for CEBPZ Gene
Post-translational modifications for CEBPZ Gene
Other Protein References for CEBPZ Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CEBPZ
-
Custom Antibody ServicesOriGene Antibodies for CEBPZ
- Novus Biologicals Antibodies for CEBPZ
- Invitrogen Antibodies for CEBPZ
- antibodies-online Antibodies for CEBPZ: See all 49
- GeneTex CEBPZ antibody for CEBPZ
Protein Products
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Assay Products
- antibodies-online Kits for CEBPZ: See all 2
No data available for DME Specific Peptides for CEBPZ Gene
Domains & Families for CEBPZ Gene
Gene Families for CEBPZ Gene
Protein Domains for CEBPZ Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for CEBPZ Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q03701- Family:
-
- Belongs to the CBF/MAK21 family.
Function for CEBPZ Gene
Molecular function for CEBPZ Gene
- UniProtKB/Swiss-Prot Function:
- Stimulates transcription from the HSP70 promoter.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IDA | 2247079 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IDA | 2247079 |
| GO:0003677 | DNA binding | TAS | 2247079 |
| GO:0003723 | RNA binding | IDA | 22658674 |
Phenotypes for CEBPZ Gene
- GenomeRNAi human phenotypes for CEBPZ:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CEBPZ gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CEBPZ gene
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CRISPR Products
-
OriGene CRISPR knockouts for CEBPZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEBPZ
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miRNA for CEBPZ Gene
- miRTarBase miRNAs that target CEBPZ
miRNA Products
- Search ViGene Biosciences for CEBPZ
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CEBPZ
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-
ViGene Biosciences ready-to-package AAV shRNAs for CEBPZ gene
Clone Products
-
OriGene ORF clones in human for CEBPZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- VectorBuilder custom plasmid, inducible vectors for CEBPZ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPZ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CEBPZ gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CEBPZ gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEBPZ Gene
Localization for CEBPZ Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEBPZ Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,TAS | -- |
Pathways & Interactions for CEBPZ Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Direct p53 effectors | ||
| 2 | Mesodermal Commitment Pathway | ||
| 3 | Gastric Cancer Network 2 | ||
Pathways by source for CEBPZ Gene
3 BioSystems pathways for CEBPZ Gene
Interacting Proteins for CEBPZ Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | 2247079 |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IDA | 2247079 |
No data available for SIGNOR curated interactions for CEBPZ Gene
Transcripts for CEBPZ Gene
mRNA/cDNA for CEBPZ Gene
- (1) REFSEQ mRNAs :
- (4) Additional mRNA sequences :
- (170) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CEBPZ Gene
CRISPR Products
-
OriGene CRISPR knockouts for CEBPZ
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEBPZ
- GenScript: Design CRISPR guide RNA sequences for CEBPZ
miRNA Products
- Search ViGene Biosciences for CEBPZ
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CEBPZ
- Browse OriGene Inhibitory RNA Products For CEBPZ
-
ViGene Biosciences ready-to-package AAV shRNAs for CEBPZ gene
Clone Products
-
OriGene ORF clones in human for CEBPZ
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CEBPZ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPZ
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CEBPZ Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Bone (Muscoskeletal System)
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Bone Marrow
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Limb (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Testis (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEBPZ Gene
NURSA nuclear receptor signaling pathways regulating expression of CEBPZ Gene:
CEBPZSOURCE GeneReport for Unigene cluster for CEBPZ Gene:
Hs.135406Evidence on tissue expression from TISSUES for CEBPZ Gene
- Liver(4.3)
- Nervous system(3.5)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for CEBPZ
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPZ Gene
Orthologs for CEBPZ Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CEBPZ 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | CEBPZ 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CEBPZ 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Cebpz 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cebpz 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | CEBPZ 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | CEBPZ 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | CEBPZ 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | CEBPZ 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cebpz 34 |
|
||
| Str.7416 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.10705 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | cebpz 34 35 |
|
||
| wufi26d06 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6779 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG7839 35 |
|
OneToOne | |
| worm (Caenorhabditis elegans) |
Secernentea | CELE_F23B12.7 34 |
|
||
| F23B12.7 35 |
|
OneToOne | |||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | MAK21 34 35 37 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E12519g 34 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_AER174W 34 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | SPAC4F10.09c 34 |
|
||
| bread mold (Neurospora crassa) |
Ascomycetes | NCU09894 34 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne |
- Species where no ortholog for CEBPZ was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CEBPZ Gene
No data available for Paralogs for CEBPZ Gene
Variants for CEBPZ Gene
| SNP ID | Clin | Chr 02 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs756442818 | Likely benign | 37,231,724(+) | TGAGG(A/T)CAGGT | nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime | |
| rs386352290 | Uncertain significance | 37,228,554(-) | CTGTA(G/T)CAGCA | reference, stop-gained | |
| rs73927405 | Uncertain significance | 37,231,728(+) | GTCAG(A/G)TTTGG | nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime | |
| rs764894035 | Uncertain significance | 37,231,706(+) | TCAGC(A/G)TGAGT | nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime | |
| rs145277736 | Benign | 37,231,669(+) | GCCCC(-/A)GCTCC | nc-transcript-variant, upstream-variant-2KB, utr-variant-5-prime |
Relevant External Links for CEBPZ Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CEBPZ
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPZ Gene
Disorders for CEBPZ Gene
Relevant External Links for CEBPZ
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- CEBPZ
No disorders were found for CEBPZ Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEBPZ Gene
Publications for CEBPZ Gene
- A cloned human CCAAT-box-binding factor stimulates transcription from the human hsp70 promoter. (PMID: 2247079) Lum L. … Wu B. (Mol. Cell. Biol. 1990) 2 3 4 22 64
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression. (PMID: 12534345) Uramoto H. … Kohno K. (Biochem. J. 2003) 2 3 64
Products for CEBPZ Gene
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- Custom Antibody ServicesOriGene Antibodies for CEBPZ
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- Novus Biologicals Tissue Microarrays
- antibodies-online Antibodies for CEBPZ: See all 49
- antibodies-online Kits for CEBPZ: See all 2
- Search antibodies-online for proteins
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- GeneTex CEBPZ antibody for CEBPZ
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- ViGene Biosciences adenoviral particle packaged cDNA for CEBPZ gene
- ViGene Biosciences lentiviral particle packaged cDNA for CEBPZ gene
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- Search ViGene Biosciences for CEBPZ
- Cyagen custom Knockout/knockin (KOKI) mouse models for CEBPZ
- VectorBuilder custom plasmid, inducible vectors for CEBPZ
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPZ
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CEBPZ Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




