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CEBPG Gene

protein-coding   GIFtS: 57
GCID: GC19P033864

CCAAT/Enhancer Binding Protein (C/EBP), Gamma

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Gamma1 2
C/EBP Gamma2 3
GPE1BP2 5
IG/EBP-12
CCAAT/Enhancer-Binding Protein Gamma2

External Ids:    HGNC: 18371   Entrez Gene: 10542   Ensembl: ENSG000001538797   OMIM: 1389725   UniProtKB: P535673   

Export aliases for CEBPG gene to outside databases

Previous GC identifers: GC19P034482 GC19P034313 GC19P038540 GC19P038556 GC19P030365


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEBPG Gene:
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated
transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal
half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization.
The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that
form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate
with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for
this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for CEBPG Gene:
CEBPG (CCAAT/enhancer binding protein (C/EBP), gamma) is a protein-coding gene. Diseases associated with CEBPG include bronchogenic carcinoma, and acute myeloid leukemia. GO annotations related to this gene include protein heterodimerization activity and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CEBPA.

UniProtKB/Swiss-Prot: CEBPG_HUMAN, P53567
Function: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the
IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual
DNA sites

Gene Wiki entry for CEBPG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEBPG gene promoter:
         Pax-5   ATF-2   Olf-1   FOXD1   Tal-1beta   C/EBPalpha   AREB6   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CEBPG promoter sequence
   Search Chromatin IP Primers for CEBPG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEBPG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.11   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.2

CEBPG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPG gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P033864:  view genomic region     (about GC identifiers)

Start:
33,864,236 bp from pter      End:
33,873,592 bp from pter
Size:
9,357 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CEBPG_HUMAN, P53567 (See protein sequence)
Recommended Name: CCAAT/enhancer-binding protein gamma  
Size: 150 amino acids; 16408 Da
Subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha and beta and with Fos protein.
Interacts with ZNF638; this interaction increases transcriptional activation (By similarity)
Secondary accessions: B2R946 Q5U052

Explore the universe of human proteins at neXtProt for CEBPG: NX_P53567

Explore proteomics data for CEBPG at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys113
  • Modification sites at PhosphoSitePlus

  • See CEBPG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239225.1  NP_001797.1  

    ENSEMBL proteins: 
     ENSP00000284000   ENSP00000466022  

    CEBPG Human Recombinant Protein Products:

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    Novus Biologicals CEBPG Proteins
    Novus Biologicals CEBPG Lysates
    Sino Biological Recombinant Protein for CEBPG
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CEBPG
    Browse Proteins at Cloud-Clone Corp.

    CEBPG Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for CEBPG
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    ThermoFisher Antibodies for CEBPG
    LSBio Antibodies in human, mouse, rat for CEBPG

    CEBPG Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    1 InterPro protein domain:
     IPR004827 bZIP

    Graphical View of Domain Structure for InterPro Entry P53567

    ProtoNet protein and cluster: P53567

    UniProtKB/Swiss-Prot: CEBPG_HUMAN, P53567
    Similarity: Belongs to the bZIP family. C/EBP subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CEBPG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEBPG_HUMAN, P53567
    Function: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the
    IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual
    DNA sites

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA7665092
    GO:0003690double-stranded DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0005515protein binding IPI7665092
    GO:0008134transcription factor binding IDA7665092
         
    CEBPG for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cebpg):
     hematopoietic system  immune system  mortality/aging  respiratory system 

    CEBPG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cebpgtm1Aki for CEBPG

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEBPG
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEBPG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEBPG
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEBPG

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEBPG:
    hsa-mir-33a-5p (MIRT028205), hsa-mir-125b-5p (MIRT002387), hsa-mir-186-5p (MIRT045272), hsa-mir-361-5p (MIRT020090), hsa-mir-652-3p (MIRT039508)

    Block miRNA regulation of human, mouse, rat CEBPG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEBPG (see all 33):
    hsa-miR-342-3p hsa-miR-374a* hsa-miR-124 hsa-miR-3658 hsa-miR-29a* hsa-miR-506 hsa-miR-30c-2* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCEBPG 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEBPG
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPG

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEBPG

    Clone
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    OriGene clones in human, mouse for CEBPG (see all 7)
    OriGene ORF clones in mouse, rat for CEBPG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEBPG (NM_001806)
    Sino Biological Human cDNA Clone for CEBPG
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPG

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CEBPG
    Browse ESI BIO Cell Lines and PureStem Progenitors for CEBPG 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPG


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEBPG_HUMAN, P53567: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS7501458
    GO:0005730NOT nucleolus IDA--

    CEBPG for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEBPG About    
    See pathways by source

    SuperPathContained pathways About
    1Akt Signaling
    p38 Signaling0.60
    2Tuberculosis
    Tuberculosis

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CEBPG
        p38 Signaling



    1 Kegg Pathway  (Kegg details for CEBPG):
        Tuberculosis


    CEBPG for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPG: 
              Transcription Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CEBPG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for CEBPG (P535672, 3 ENSP000002840004) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLLT6P551982, 3, ENSP000003164264MINT-66061 I2D: score=5 STRING: ENSP00000316426
    MYZAPP0CAP12, 3MINT-67959 I2D: score=4 
    DDIT3P356382, 3, ENSP000003406714MINT-68484 I2D: score=8 STRING: ENSP00000340671
    CEBPDP497163, ENSP000003861654I2D: score=3 STRING: ENSP00000386165
    CREB3L3Q68CJ93, ENSP000000784454I2D: score=2 STRING: ENSP00000078445
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001889liver development ISS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006357regulation of transcription from RNA polymerase II promoter IDA16255782
    GO:0006955immune response ISS--

    CEBPG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEBPG



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CEBPG gene (2 alternative transcripts): 
    NM_001252296.1  NM_001806.3  

    Unigene Cluster for CEBPG:

    CCAAT/enhancer binding protein (C/EBP), gamma
    Hs.429666  [show with all ESTs]
    Unigene Representative Sequence: NM_001806
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000284000(uc002nup.3 uc021usd.1) ENST00000585933
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CEBPG using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEBPG (see all 33):
    hsa-miR-342-3p hsa-miR-374a* hsa-miR-124 hsa-miR-3658 hsa-miR-29a* hsa-miR-506 hsa-miR-30c-2* hsa-miR-3163
    SwitchGear 3'UTR luciferase reporter plasmidCEBPG 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CEBPG
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPG
    Clone
    Products:
         
    OriGene clones in human, mouse for CEBPG (see all 7)
    OriGene ORF clones in mouse, rat for CEBPG
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEBPG (NM_001806)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPG
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPG
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CEBPG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPG
      QuantiTect SYBR Green Assays in human, mouse, rat CEBPG
      QuantiFast Probe-based Assays in human, mouse, rat CEBPG

    Additional mRNA sequence: 

    AK313634.1 BC007582.1 BC013128.1 BT019819.1 BT019820.1 U20240.1 

    4 DOTS entries:

    DT.412551  DT.100792456  DT.95285860  DT.95285861 

    Selected AceView cDNA sequences (see all 225):

    CB991797 AA909416 BG527767 BP376678 AA632929 AA027181 CR624171 F05841 
    AA693441 BM472330 CB133378 CR607743 CK904180 AI262856 BQ787834 AI478807 
    AI285251 AI280858 BC007582 AW953050 BC013128 AA551887 BM068812 BQ084022 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEBPG expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTCAAAGAC
    CEBPG Expression
    About this image


    CEBPG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 8 entries
             Sacral Brown Adipocyte Cells Sacral Brown Adipose Depot
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Hippocampus
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CEBPG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEBPG Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.429666
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPG: 
              Transcription Factors in human mouse rat
              Apoptosis 384HT in human mouse rat
              Hematopoiesis in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CEBPG
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPG
    QuantiTect SYBR Green Assays in human, mouse, rat CEBPG
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CEBPG gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cebpg1 , 5 CCAAT/enhancer binding protein (C/EBP), gamma1, 5 85.56(n)1
    91.33(a)1
      7 (20.91 cM)5
    126111  NM_009884.31  NP_034014.11 
     350464225 
    chicken
    (Gallus gallus)
    Aves CEBPG1 CCAAT/enhancer binding protein (C/EBP), gamma 77.33(n)
    82(a)
      395800  NM_206859.1  NP_996741.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEBPG6
    CCAAT/enhancer binding protein (C/EBP), gamma
    77(a)
    1 ↔ 1
    GL343508.1(634388-634840)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.52402 Xenopus laevis transcribed sequence with weak similarity more 79.2(n)    BJ072603.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cebpg2 CCAAT/enhancer binding protein (C/EBP), gamma 80(n)   140816  BC049400.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cebp-26
    Protein CEBP-2 (cebp-2) mRNA, complete cds
    33(a)
    1 → many
    I(6253019-6253583) WBGene00016754


    ENSEMBL Gene Tree for CEBPG (if available)
    TreeFam Gene Tree for CEBPG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEBPG gene
    CEBPA2  CEBPD2  CEBPB2  CEBPE2  
    2 SIMAP similar genes for CEBPG using alignment to 1 protein entry:     CEBPG_HUMAN:
    CEBPD    CEBPB

    CEBPG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEBPG (see all 203)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735843491,2
    C,F--33862642(+) TTTGAG/AACCAG 1 -- us2k14Minor allele frequency- A:0.07WA CSA NA 242
    rs1464236361,2
    C--33862783(+) AGGCT-/GCAGCAGT 1 -- cds10--------
    rs2019154671,2
    C--33862784(+) TGCAG-/CA    
       G
    /GCA
    TGAGC
    2 -- cds10--------
    rs1456925701,2
    --33862913(+) AAACAC/TACTTG 1 -- us2k10--------
    rs1485916581,2
    --33862933(+) CACTTA/GTTCTC 1 -- us2k10--------
    rs775925441,2
    C,F--33862935(+) CTTATT/GCTCCT 1 -- us2k15Minor allele frequency- G:0.23WA CSA NA EA 362
    rs1884987501,2
    --33863018(+) CTGGAC/GTGCAG 1 -- us2k10--------
    rs611806611,2
    C,F--33863052(+) ACCTCC/TGCCTC 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs796616761,2
    C,F--33863054(+) CTCCGC/TCTCTC 1 -- us2k14Minor allele frequency- T:0.21NA EA 244
    rs1813104141,2
    --33863308(+) TTTATC/TGCTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEBPG (33864236 - 33873592 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CEBPG:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3845n71CNV Loss21882294
    nsv828526CNV Loss20364138
    nsv911597CNV Loss21882294
    dgv1073e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEBPG
    DNA2.0 Custom Variant and Variant Library Synthesis for CEBPG

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 138972    OMIM disorders: --

    11 diseases for CEBPG:    
    About MalaCards
    bronchogenic carcinoma    acute myeloid leukemia    tuberculosis    hepatitis b
    myeloid leukemia    tonsillitis    inflammatory bowel disease    hepatitis
    leukemia    cervicitis    cerebritis

    1 disease from the University of Copenhagen DISEASES database for CEBPG:
    Bronchogenic carcinoma

    CEBPG for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CEBPG (2 documents)

    Export disorders for CEBPG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEBPG gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with CEBPG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Cloning of the cDNA encoding human C/EBP gamma, a protein binding to the PRE-I enhancer element of the human interleukin-4 promoter. (PubMed id 7665092)1, 2 Davydov I.V.... Li-Weber M. (Gene 1995)
    3. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. (PubMed id 1884998)1, 3 Williams S.C....Johnson P.F. (amp 1991)
    4. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. (PubMed id 12177065)1, 9 Gao H....Schwartz R.C. (J. Biol. Chem. 2002)
    5. C/EBPI^ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPI^. (PubMed id 23775115)1 Huggins C.J....Johnson P.F. (Mol. Cell. Biol. 2013)
    6. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (Science 2013)
    7. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    8. Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (Nature 2012)
    9. C/EBPI^ regulates wound repair and EGF receptor signaling. (PubMed id 22437320)1 Melchionna R....Napolitano M. (J. Invest. Dermatol. 2012)
    10. C/EBPI^ deregulation results in differentiation arrest in acute myeloid leukemia. (PubMed id 23160200)1 Alberich-JordA M....Tenen D.G. (J. Clin. Invest. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1054 HGNC: 1837 AceView: CEBPG Ensembl:ENSG00000153879 euGenes: HUgn1054
    ECgene: CEBPG Kegg: 1054 H-InvDB: CEBPG

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEBPG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEBPG gene:
    Search GeneIP for patents involving CEBPG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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