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Aliases for CEBPG Gene

Aliases for CEBPG Gene

  • CCAAT/Enhancer Binding Protein Gamma 2 3
  • CCAAT/Enhancer Binding Protein (C/EBP), Gamma 2 3 5
  • C/EBP Gamma 3 4
  • IG/EBP-1 3
  • GPE1BP 3

External Ids for CEBPG Gene

Previous GeneCards Identifiers for CEBPG Gene

  • GC19P034482
  • GC19P034313
  • GC19P038540
  • GC19P038556
  • GC19P033864
  • GC19P030365

Summaries for CEBPG Gene

Entrez Gene Summary for CEBPG Gene

  • The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CEBPG Gene

CEBPG (CCAAT/Enhancer Binding Protein Gamma) is a Protein Coding gene. Among its related pathways are Akt Signaling and Tuberculosis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and protein heterodimerization activity. An important paralog of this gene is CEBPA.

UniProtKB/Swiss-Prot for CEBPG Gene

  • Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

Gene Wiki entry for CEBPG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPG Gene

Genomics for CEBPG Gene

Regulatory Elements for CEBPG Gene

Promoters for CEBPG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEBPG on UCSC Golden Path with GeneCards custom track

Genomic Location for CEBPG Gene

Chromosome:
19
Start:
33,373,330 bp from pter
End:
33,382,686 bp from pter
Size:
9,357 bases
Orientation:
Plus strand

Genomic View for CEBPG Gene

Genes around CEBPG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEBPG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEBPG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPG Gene

Proteins for CEBPG Gene

  • Protein details for CEBPG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53567-CEBPG_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein gamma
    Protein Accession:
    P53567
    Secondary Accessions:
    • B2R946
    • Q5U052

    Protein attributes for CEBPG Gene

    Size:
    150 amino acids
    Molecular mass:
    16408 Da
    Quaternary structure:
    • Binds DNA as a dimer and can form stable heterodimers with CEBPA and CEBPB. Interacts with ZNF638; this interaction increases transcriptional activation.

neXtProt entry for CEBPG Gene

Proteomics data for CEBPG Gene at MOPED

Post-translational modifications for CEBPG Gene

  • Ubiquitination at Lys 113
  • Modification sites at PhosphoSitePlus

Other Protein References for CEBPG Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cloud-Clone Corp. Antibodies for CEBPG

No data available for DME Specific Peptides for CEBPG Gene

Domains & Families for CEBPG Gene

Protein Domains for CEBPG Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPG Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P53567

UniProtKB/Swiss-Prot:

CEBPG_HUMAN :
  • Contains 1 bZIP (basic-leucine zipper) domain.
  • Belongs to the bZIP family. C/EBP subfamily.
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. C/EBP subfamily.
genes like me logo Genes that share domains with CEBPG: view

Function for CEBPG Gene

Molecular function for CEBPG Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that binds to the promoter and the enhancer regions of target genes. Binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene (PubMed:7665092). Binds to the promoter and the enhancer of the immunoglobulin heavy chain. Binds to GPE1, a cis-acting element in the G-CSF gene promoter.

Gene Ontology (GO) - Molecular Function for CEBPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IDA 15833715
GO:0003690 double-stranded DNA binding IEA --
GO:0008134 transcription factor binding IDA 7665092
GO:0042803 protein homodimerization activity IEA --
GO:0043565 sequence-specific DNA binding IEA,IDA 7665092
genes like me logo Genes that share ontologies with CEBPG: view
genes like me logo Genes that share phenotypes with CEBPG: view

Animal Models for CEBPG Gene

MGI Knock Outs for CEBPG:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEBPG Gene

Localization for CEBPG Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPG Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEBPG Gene COMPARTMENTS Subcellular localization image for CEBPG gene
Compartment Confidence
nucleus 5
cytosol 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for CEBPG Gene

Pathways & Interactions for CEBPG Gene

SuperPathways for CEBPG Gene

Superpath Contained pathways
1 Akt Signaling
2 Tuberculosis
genes like me logo Genes that share pathways with CEBPG: view

Pathways by source for CEBPG Gene

1 KEGG pathway for CEBPG Gene
1 Qiagen pathway for CEBPG Gene

Gene Ontology (GO) - Biological Process for CEBPG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006955 immune response ISS --
GO:0030183 B cell differentiation ISS --
GO:0042267 natural killer cell mediated cytotoxicity ISS --
genes like me logo Genes that share ontologies with CEBPG: view

No data available for SIGNOR curated interactions for CEBPG Gene

Drugs & Compounds for CEBPG Gene

No Compound Related Data Available

Transcripts for CEBPG Gene

mRNA/cDNA for CEBPG Gene

Unigene Clusters for CEBPG Gene

CCAAT/enhancer binding protein (C/EBP), gamma:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPG Gene

No ASD Table

Relevant External Links for CEBPG Gene

GeneLoc Exon Structure for
CEBPG
ECgene alternative splicing isoforms for
CEBPG

Expression for CEBPG Gene

mRNA expression in normal human tissues for CEBPG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CEBPG Gene

This gene is overexpressed in Blymphocyte (49.1) and Fetal heart (19.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEBPG Gene



SOURCE GeneReport for Unigene cluster for CEBPG Gene Hs.429666

genes like me logo Genes that share expression patterns with CEBPG: view

Protein tissue co-expression partners for CEBPG Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEBPG Gene

Orthologs for CEBPG Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEBPG 35
  • 99.11 (n)
  • 99.33 (a)
CEBPG 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEBPG 36
  • 95 (a)
OneToOne
CEBPG 35
  • 91.05 (n)
  • 95.3 (a)
dog
(Canis familiaris)
Mammalia CEBPG 35
  • 89.34 (n)
  • 93.2 (a)
CEBPG 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cebpg 36
  • 91 (a)
OneToOne
Cebpg 16
Cebpg 35
  • 85.56 (n)
  • 91.33 (a)
oppossum
(Monodelphis domestica)
Mammalia CEBPG 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPG 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cebpg 35
  • 84.89 (n)
  • 92.67 (a)
chicken
(Gallus gallus)
Aves C 36
  • 82 (a)
OneToOne
CEBPG 35
  • 77.33 (n)
  • 82 (a)
lizard
(Anolis carolinensis)
Reptilia CEBPG 36
  • 77 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.5240 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpg 35
  • 69.44 (n)
  • 80 (a)
Str.6360 35
zebrafish
(Danio rerio)
Actinopterygii cebpg 36
  • 66 (a)
OneToOne
cebpg 35
  • 69.25 (n)
  • 74.65 (a)
worm
(Caenorhabditis elegans)
Secernentea cebp-2 36
  • 33 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 12 (a)
OneToMany
Species with no ortholog for CEBPG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPG Gene

ENSEMBL:
Gene Tree for CEBPG (if available)
TreeFam:
Gene Tree for CEBPG (if available)

Paralogs for CEBPG Gene

Paralogs for CEBPG Gene

(2) SIMAP similar genes for CEBPG Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CEBPG: view

Variants for CEBPG Gene

Sequence variations from dbSNP and Humsavar for CEBPG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs14093 -- 33,382,293(-) TGGTC(A/G)TGTTT utr-variant-3-prime
rs3745967 -- 33,374,012(+) CGGCC(C/G)GCTGG intron-variant, upstream-variant-2KB
rs3745968 -- 33,381,504(+) GGAGT(A/G)TGAAT utr-variant-3-prime
rs34130404 -- 33,378,147(+) CACTT(-/A)CTTGG intron-variant
rs34508930 -- 33,380,239(+) GTTTT(-/TC)CCCCC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEBPG Gene

Variant ID Type Subtype PubMed ID
dgv1073e1 CNV Complex 17122850
nsv911597 CNV Loss 21882294
nsv828526 CNV Loss 20364138
dgv3845n71 CNV Loss 21882294

Variation tolerance for CEBPG Gene

Residual Variation Intolerance Score: 47.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.14; 3.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEBPG Gene

HapMap Linkage Disequilibrium report
CEBPG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPG Gene

Disorders for CEBPG Gene

Relevant External Links for CEBPG

Human Genome Epidemiology (HuGE) Navigator
CEBPG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEBPG

No disorders were found for CEBPG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEBPG Gene

Publications for CEBPG Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. C/EBP gamma has a stimulatory role on the IL-6 and IL-8 promoters. (PMID: 12177065) Gao H. … Schwartz R.C. (J. Biol. Chem. 2002) 3 23
  3. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. (PMID: 1884998) Williams S.C. … Johnson P.F. (Genes Dev. 1991) 2 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. HIV-1 Nef induces CCL5 production in astrocytes through p38-MAPK and PI3K/Akt pathway and utilizes NF-kB, CEBP and AP-1 transcription factors. (PMID: 24658403) Liu X. … Kumar A. (Sci Rep 2014) 3

Products for CEBPG Gene

Sources for CEBPG Gene

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