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Aliases for CEBPE Gene

Aliases for CEBPE Gene

  • CCAAT/Enhancer Binding Protein (C/EBP), Epsilon 2 3
  • C/EBP Epsilon 3 4
  • CRP1 3 6
  • CCAAT/Enhancer-Binding Protein Epsilon 3
  • C/EBP-Epsilon 3

External Ids for CEBPE Gene

Previous GeneCards Identifiers for CEBPE Gene

  • GC14M020959
  • GC14M017373
  • GC14M021576
  • GC14M022656
  • GC14M023586
  • GC14M003703

Summaries for CEBPE Gene

Entrez Gene Summary for CEBPE Gene

  • The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for CEBPE Gene

CEBPE (CCAAT/Enhancer Binding Protein (C/EBP), Epsilon) is a Protein Coding gene. Diseases associated with CEBPE include specific granule deficiency and neutrophil-specific granule deficiency. Among its related pathways are Transcriptional misregulation in cancer. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CEBPG.

UniProtKB/Swiss-Prot for CEBPE Gene

  • C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers

Gene Wiki entry for CEBPE Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPE Gene

Genomics for CEBPE Gene

Regulatory Elements for CEBPE Gene

Genomic Location for CEBPE Gene

Start:
23,117,304 bp from pter
End:
23,119,616 bp from pter
Size:
2,313 bases
Orientation:
Minus strand

Genomic View for CEBPE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEBPE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPE Gene

Proteins for CEBPE Gene

  • Protein details for CEBPE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15744-CEBPE_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein epsilon
    Protein Accession:
    Q15744
    Secondary Accessions:
    • Q15745
    • Q8IYI2
    • Q99803

    Protein attributes for CEBPE Gene

    Size:
    281 amino acids
    Molecular mass:
    30603 Da
    Quaternary structure:
    • Binds DNA as a dimer and can form stable heterodimers with C/EBP delta
    SequenceCaution:
    • Sequence=AAC51130.1; Type=Frameshift; Positions=4; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEBPE Gene

neXtProt entry for CEBPE Gene

Proteomics data for CEBPE Gene at MOPED

Post-translational modifications for CEBPE Gene

Other Protein References for CEBPE Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPE Gene

Domains for CEBPE Gene

Gene Families for CEBPE Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CEBPE Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15744

UniProtKB/Swiss-Prot:

CEBPE_HUMAN :
  • Q15744
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. C/EBP subfamily.
genes like me logo Genes that share domains with CEBPE: view

Function for CEBPE Gene

Molecular function for CEBPE Gene

GENATLAS Biochemistry:
CCAAT enhancer binding protein epsilon,expressed in peripheral blood mononuclear cells and in ovaries
UniProtKB/Swiss-Prot Function:
C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers

Gene Ontology (GO) - Molecular Function for CEBPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IDA 10233885
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA 10233885
GO:0003677 DNA binding --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0042803 protein homodimerization activity IEA --
genes like me logo Genes that share ontologies with CEBPE: view
genes like me logo Genes that share phenotypes with CEBPE: view

Animal Models for CEBPE Gene

MGI Knock Outs for CEBPE:

Animal Model Products

miRNA for CEBPE Gene

miRTarBase miRNAs that target CEBPE

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CEBPE Gene

Localization for CEBPE Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPE Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEBPE Gene COMPARTMENTS Subcellular localization image for CEBPE gene
Compartment Confidence
nucleus 5
lysosome 2
vacuole 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CEBPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CEBPE: view

Pathways for CEBPE Gene

genes like me logo Genes that share pathways with CEBPE: view

Pathways by source for CEBPE Gene

1 KEGG pathway for CEBPE Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CEBPE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006909 phagocytosis IEA --
GO:0006952 defense response TAS 8661101
GO:0010628 positive regulation of gene expression --
genes like me logo Genes that share ontologies with CEBPE: view

Transcripts for CEBPE Gene

mRNA/cDNA for CEBPE Gene

(10) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEBPE Gene

CCAAT/enhancer binding protein (C/EBP), epsilon:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEBPE

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPE Gene

No ASD Table

Relevant External Links for CEBPE Gene

GeneLoc Exon Structure for
CEBPE
ECgene alternative splicing isoforms for
CEBPE

Expression for CEBPE Gene

mRNA expression in normal human tissues for CEBPE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEBPE Gene

This gene is overexpressed in Whole Blood (40.1) and Spleen (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEBPE Gene

SOURCE GeneReport for Unigene cluster for CEBPE Gene Hs.558308

mRNA Expression by UniProt/SwissProt for CEBPE Gene

Q15744-CEBPE_HUMAN
Tissue specificity: Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines
genes like me logo Genes that share expressions with CEBPE: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues and Expression partners for CEBPE Gene

Orthologs for CEBPE Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEBPE 35
  • 90.15 (n)
  • 95.37 (a)
CEBPE 36
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEBPE 35
  • 91.58 (n)
  • 96.44 (a)
CEBPE 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cebpe 35
  • 88.61 (n)
  • 93.24 (a)
Cebpe 16
Cebpe 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEBPE 35
  • 99.64 (n)
  • 99.64 (a)
CEBPE 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cebpe 35
  • 88.85 (n)
  • 93.59 (a)
oppossum
(Monodelphis domestica)
Mammalia CEBPE 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPE 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEBPE 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpe 35
  • 60.03 (n)
  • 60.16 (a)
zebrafish
(Danio rerio)
Actinopterygii cebp1 36
  • 30 (a)
ManyToMany
CU633479.4 36
  • 30 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea cebp-2 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
OneToMany
Species with no ortholog for CEBPE:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPE Gene

ENSEMBL:
Gene Tree for CEBPE (if available)
TreeFam:
Gene Tree for CEBPE (if available)

Paralogs for CEBPE Gene

Paralogs for CEBPE Gene

Selected SIMAP similar genes for CEBPE Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CEBPE: view

Variants for CEBPE Gene

Sequence variations from dbSNP and Humsavar for CEBPE Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1474920 -- 23,118,346(-) TTGAT(A/C)TCAGG intron-variant
rs2144827 -- 23,118,022(-) TCAAG(C/T)AGAGG intron-variant
rs2239630 -- 23,120,140(-) CAGGG(C/T)GAGGG upstream-variant-2KB
rs2239631 -- 23,119,921(-) ACTAA(C/T)ATGTG upstream-variant-2KB
rs2239632 -- 23,119,918(-) AACAT(G/T)TGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CEBPE Gene

Variant ID Type Subtype PubMed ID
nsv901492 CNV Loss 21882294

Relevant External Links for CEBPE Gene

HapMap Linkage Disequilibrium report
CEBPE
Human Gene Mutation Database (HGMD)
CEBPE
Locus Specific Mutation Databases (LSDB)
CEBPE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPE Gene

Disorders for CEBPE Gene

(1) OMIM Diseases for CEBPE Gene (600749)

(1) University of Copenhagen DISEASES for CEBPE Gene

Relevant External Links for CEBPE

Genetic Association Database (GAD)
CEBPE
Human Genome Epidemiology (HuGE) Navigator
CEBPE
genes like me logo Genes that share disorders with CEBPE: view

No data available for UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CEBPE Gene

Publications for CEBPE Gene

  1. A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. (PMID: 8661101) Antonson P. … Xanthopoulos K.G. (Genomics 1996) 2 3 4 23
  2. Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. (PMID: 9032264) Chumakov A.M. … Koeffler H.P. (Mol. Cell. Biol. 1997) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human C/EBP-epsilon activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation. (PMID: 18832658) Bedi R. … Ackerman S.J. (Blood 2009) 3 23
  5. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. (PMID: 19684604) Papaemmanuil E. … Houlston R.S. (Nat. Genet. 2009) 3 48

Products for CEBPE Gene

Sources for CEBPE Gene

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