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CEBPE Gene

protein-coding   GIFtS: 59
GCID: GC14M023586

CCAAT/Enhancer Binding Protein (C/EBP), Epsilon

  See CEBPE-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Epsilon1 2
C/EBP Epsilon2 3
CRP12 5
C/EBP-epsilon2
CCAAT/Enhancer-Binding Protein Epsilon2

External Ids:    HGNC: 18361   Entrez Gene: 10532   Ensembl: ENSG000000920677   OMIM: 6007495   UniProtKB: Q157443   

Export aliases for CEBPE gene to outside databases

Previous GC identifers: GC14M020959 GC14M017373 GC14M021576 GC14M022656 GC14M003703


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEBPE Gene:
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA
regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be
essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells.
Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder.
Multiple variants of this gene have been described, but the full-length nature of only one has been determined.
(provided by RefSeq, Jul 2008)

GeneCards Summary for CEBPE Gene:
CEBPE (CCAAT/enhancer binding protein (C/EBP), epsilon) is a protein-coding gene. Diseases associated with CEBPE include neutrophil-specific granule deficiency, and severe congenital neutropenia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CEBPA.

UniProtKB/Swiss-Prot: CEBPE_HUMAN, Q15744
Function: C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many
promoters and the enhanced core homology common to many enhancers

Gene Wiki entry for CEBPE Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEBPE gene promoter:
         GR   STAT1   GATA-3   AP-1   STAT1beta   STAT1alpha   Ik-2   COMP1   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEBPE promoter sequence
   Search Chromatin IP Primers for CEBPE

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEBPE


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

CEBPE Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPE gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023586:  view genomic region     (about GC identifiers)

Start:
23,586,513 bp from pter      End:
23,588,825 bp from pter
Size:
2,313 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CEBPE_HUMAN, Q15744 (See protein sequence)
Recommended Name: CCAAT/enhancer-binding protein epsilon  
Size: 281 amino acids; 30603 Da
Subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP delta
Sequence caution: Sequence=AAC51130.1; Type=Frameshift; Positions=4;
1 PDB 3D structure from and Proteopedia for CEBPE:
3T92 (3D)    
Secondary accessions: Q15745 Q8IYI2 Q99803

Explore the universe of human proteins at neXtProt for CEBPE: NX_Q15744

Explore proteomics data for CEBPE at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CEBPE Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001796.2  
    ENSEMBL proteins: 
     ENSP00000206513  

    CEBPE Human Recombinant Protein Products:

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    Novus Biologicals CEBPE Lysates
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CEBPE 

    CEBPE Antibody Products:

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    LSBio Antibodies in human, mouse, rat for CEBPE

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CEBPE 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR016468 CCAAT/enhancer-binding

    Graphical View of Domain Structure for InterPro Entry Q15744

    ProtoNet protein and cluster: Q15744

    UniProtKB/Swiss-Prot: CEBPE_HUMAN, Q15744
    Similarity: Belongs to the bZIP family. C/EBP subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with CEBPE           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEBPE_HUMAN, Q15744
    Function: C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many
    promoters and the enhanced core homology common to many enhancers

         Genatlas biochemistry entry for CEBPE:
    CCAAT enhancer binding protein epsilon,expressed in peripheral blood mononuclear cells and in ovaries

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0042803protein homodimerization activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
    GO:0046982protein heterodimerization activity IEA--
         
    Find genes that share ontologies with CEBPE           About GenesLikeMe


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cebpe):
     cellular  digestive/alimentary  hematopoietic system  immune system  integument 
     mortality/aging  respiratory system  skeleton  vision/eye 

    Find genes that share phenotypes with CEBPE           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cebpetm1Kgx for CEBPE

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEBPE
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEBPE

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEBPE
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEBPE

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEBPE:
    hsa-mir-124-3p (MIRT022958)

    Block miRNA regulation of human, mouse, rat CEBPE using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CEBPE:
    hsa-miR-301b hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-301a hsa-miR-130b hsa-miR-3666 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidCEBPE 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEBPE
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPE

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: CEBPE (NM_001805)
    Sino Biological Human cDNA Clone for CEBPE
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPE

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPE


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEBPE_HUMAN, Q15744: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    lysosome2
    vacuole2
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--

    Find genes that share ontologies with CEBPE           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEBPE About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional misregulation in cancer
    Transcriptional misregulation in cancer


    Find genes that share SuperPaths with CEBPE           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways




    1 Kegg Pathway  (Kegg details for CEBPE):
        Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including CEBPE: 
              Hematopoiesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CEBPE

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CEBPE (Q157442, 3 ENSP000002065134) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DOCK1Q141852, 3MINT-7231963 I2D: score=1 
    CEBPDP497163, ENSP000003861654I2D: score=4 STRING: ENSP00000386165
    MLLT6P551983, ENSP000003164264I2D: score=3 STRING: ENSP00000316426
    PIAS1O759253, ENSP000002496364I2D: score=3 STRING: ENSP00000249636
    SPI1P179473, ENSP000002271634I2D: score=3 STRING: ENSP00000227163
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006909phagocytosis IEA--
    GO:0006952defense response TAS8661101
    GO:0010628positive regulation of gene expression IEA--

    Find genes that share ontologies with CEBPE           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEBPE



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CEBPE gene: 
    NM_001805.3  

    Unigene Cluster for CEBPE:

    CCAAT/enhancer binding protein (C/EBP), epsilon
    Hs.558308  [show with all ESTs]
    Unigene Representative Sequence: NM_001805
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000206513(uc001wiv.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CEBPE using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CEBPE:
    hsa-miR-301b hsa-miR-454 hsa-miR-4295 hsa-miR-130a hsa-miR-301a hsa-miR-130b hsa-miR-3666 hsa-miR-3157-5p
    SwitchGear 3'UTR luciferase reporter plasmidCEBPE 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CEBPE
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPE
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPE
    Primer
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    OriGene qPCR primer pairs and template standards for CEBPE
    OriGene qSTAR qPCR primer pairs in human, mouse for CEBPE
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPE
      QuantiTect SYBR Green Assays in human, mouse, rat CEBPE
      QuantiFast Probe-based Assays in human, mouse, rat CEBPE

    Additional mRNA sequence: 

    BC035797.1 U48866.1 

    2 DOTS entries:

    DT.105398  DT.100785526 

    10 AceView cDNA sequences:

    BC035797 CR594219 NM_001805 BG387972 BX326176 BU617231 BM907144 CA427525 
    BX346756 BX346755 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEBPE expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATAAATGGC
    CEBPE Expression
    About this image


    CEBPE expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Endochondral Osteoblasts Autopod Periosteum
             Bone Marrow
             bone marrow   
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
             bone marrow   
    CEBPE Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEBPE Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558308

    UniProtKB/Swiss-Prot: CEBPE_HUMAN, Q15744
    Tissue specificity: Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines

        Pathway & Disease-focused RT2 Profiler PCR Array including CEBPE: 
              Hematopoiesis in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CEBPE gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cebpe1 , 5 CCAAT/enhancer binding protein (C/EBP), epsilon1, 5 88.61(n)1
    93.24(a)1
      14 (27.90 cM)5
    1107941  NM_207131.11  NP_997014.11 
     547103635 
    lizard
    (Anolis carolinensis)
    Reptilia CEBPE6
    CCAAT/enhancer binding protein (C/EBP), epsilon
    57(a)
    1 ↔ 1
    GL343776.1(56712-62519)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cebpe1 CCAAT/enhancer binding protein (C/EBP), epsilon 60.03(n)
    60.16(a)
      100038238  XM_002939018.2  XP_002939064.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cebp16
    CU633479.46
    Uncharacterized protein
    30(a)
    30(a)
    many ↔ many
    many ↔ many
    24(42403985-42411783) ENSDARG00000045240
    24(42563352-42568541) ENSDARG00000090254
    worm
    (Caenorhabditis elegans)
    Secernentea cebp-26
    Protein CEBP-2 (cebp-2) mRNA, complete cds
    27(a)
    1 → many
    I(6253019-6253583) WBGene00016754


    ENSEMBL Gene Tree for CEBPE (if available)
    TreeFam Gene Tree for CEBPE (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEBPE gene
    CEBPA2  CEBPD2  CEBPB2  CEBPG2  
    2 SIMAP similar genes for CEBPE using alignment to 1 protein entry:     CEBPE_HUMAN:
    CEBPB    CEBPA

    Find genes that share paralogs with CEBPE           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEBPE (see all 141)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80154781,2
    C,F,A,H--4583047(+) TGGAAA/CTGGAG 1 -- ds500142Minor allele frequency- N:0.00EA NA NS WA CSA 3772
    rs1903030951,2
    --4583115(+) TTCCCA/GTGGTC 1 -- ds50010--------
    rs740369151,2
    C,F--4583213(+) GTGCCG/AGGATC 1 -- ds50013Minor allele frequency- A:0.11WA CSA 121
    rs1387866791,2
    C--4583275(+) TCCTG-/TGGGGG 1 -- ds50010--------
    rs1916802891,2
    --4583276(+) CCTGTC/GGGGGG 1 -- ds50010--------
    rs770024211,2
    F--4583283(+) GGGGCG/AGGGAT 1 -- ds50011Minor allele frequency- A:0.06WA 118
    rs128892131,2
    C,H--4583452(+) ACCTAG/ACCACA 1 -- ds50015Minor allele frequency- A:0.00NS EA NA 422
    rs1430306631,2
    --4583597(+) CCTGCC/TCTCTT 1 -- ut310--------
    rs1178000451,2
    C--4583685(+) TAGGCC/TGTGCC 1 -- ut311Minor allele frequency- T:0.01EA 120
    rs1124206131,2
    C--4583710(+) CCACAG/ATCCAC 1 -- ut311Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for CEBPE (23586513 - 23588825 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CEBPE:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901492CNV Loss21882294

    Human Gene Mutation Database (HGMD): CEBPE
    Locus Specific Mutation Databases (LSDB): CEBPE

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEBPE
    DNA2.0 Custom Variant and Variant Library Synthesis for CEBPE

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600749   
    OMIM disorders: 245480  
    2 diseases for CEBPE:    
    About MalaCards
    neutrophil-specific granule deficiency    severe congenital neutropenia

    1 disease from the University of Copenhagen DISEASES database for CEBPE:
    Leukemia

    Find genes that share disorders with CEBPE           About GenesLikeMe

    Genetic Association Database (GAD): CEBPE
    Human Genome Epidemiology (HuGE) Navigator: CEBPE (2 documents)

    Export disorders for CEBPE gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEBPE gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with CEBPE)
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    1. A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus. (PubMed id 8661101)1, 2, 3, 9 Antonson P.... Xanthopoulos K.G. (Genomics 1996)
    2. Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor. (PubMed id 9032264)1, 2, 9 Chumakov A.M....Koeffler H.P. (Mol. Cell. Biol. 1997)
    3. Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. (PubMed id 20042726)1, 4 Prasad R.B.... Hemminki K. (Blood 2010)
    4. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. (PubMed id 19684604)1, 4 Papaemmanuil E.... Houlston R.S. (Nat. Genet. 2009)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Identification of a responsible promoter region and a key transcription factor, CCAAT/enhancer-binding protein epsilon, for up-regulation of PHGPx in HL60 cells stimulated with TNF alpha. (PubMed id 17688422)1, 9 Hattori H....Nakagawa Y. (Biochem. J. 2007)
    7. Human C/EBP-epsilon activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation. (PubMed id 18832658)1, 9 Bedi R....Ackerman S.J. (Blood 2009)
    8. C/EBPalpha and C/EBPvarepsilon induce the monocytic differentiation of myelomonocytic cells with the MLL-chimeric fusion gene. (PubMed id 18776924)1, 9 Matsushita H....Miyachi H. (Oncogene 2008)
    9. Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations. (PubMed id 23512250)1 Xu H....Yang J.J. (J. Natl. Cancer Inst. 2013)
    10. Networks of bZIP protein-protein interactions diversified over a billion years of evolution. (PubMed id 23661758)1 Reinke A.W....Keating A.E. (Science 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1053 HGNC: 1836 AceView: CEBPE Ensembl:ENSG00000092067 euGenes: HUgn1053
    ECgene: CEBPE Kegg: 1053 H-InvDB: CEBPE

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEBPE Pharmacogenomics, SNPs, Pathways
    CEBPEbasehttp://bioinf.uta.fi/CEBPEbase/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEBPE gene:
    Search GeneIP for patents involving CEBPE

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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