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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CEBPD Gene

protein-coding GIFtS: 55
GCID: GC08M048649

CCAAT/enhancer binding protein (C/EBP), delta

Explore 17 diseases affiliated with
CEBPD via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Delta¹ ²		CRP3¹ ²
NF-IL6-Beta¹		C/EBP Delta² ³
C/EBP-Delta¹		Nuclear Factor NF-IL6-Beta² ³
CELF¹ ²		CCAAT/Enhancer-Binding Protein Delta²

External Ids:	HGNC: 1835¹	Entrez Gene: 1052²	Ensembl: ENSG00000221869⁷	OMIM: 116898⁵	UniProtKB: P49716³

Export aliases for CEBPD gene to outside databases

Previous GC identifers: GC08M047759 GC08M048640 GC08M048372 GC08M048699 GC08M048812 GC08M044112

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEBPD:

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA

regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is

important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the

regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this

locus has been reported as both 8p11 and 8q11. (provided by RefSeq, Sep 2010)

UniProtKB/Swiss-Prot: CEBPD_HUMAN, P49716

Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many

promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the

regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the

several genes associated with activation and/or differentiation of macrophages

Gene Wiki entry for CEBPD

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000008.10 NC_018919.1 NT_008183.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CEBPD gene promoter:
GR TBP AP-1 ATF-2 TFIID STAT3 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CEBPD promoter sequence

Search SABiosciences Chromatin IP Primers for CEBPD

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEBPD

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2-p11.1 Ensembl cytogenetic band: 8q11.21 HGNC cytogenetic band: 8p11.2-p11.1

CEBPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPD gene location

GeneLoc information about chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M048649: view genomic region (about GC identifiers)

Start:	48,649,471 bp from pter	End:	48,651,648 bp from pter
Size:	2,178 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CEBPD_HUMAN, P49716 (See protein sequence)

Recommended Name: CCAAT/enhancer-binding protein delta

Size: 269 amino acids; 28467 Da

Subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1. Interacts

with PRDM16 (By similarity)

Subcellular location: Nucleus

Secondary accessions: Q14937 Q2M2X9

Explore the universe of human proteins at neXtProt for CEBPD: NX_P49716

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49716

CEBPD Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005186.2

ENSEMBL proteins:

ENSP00000386165

Reactome Protein details: P49716
Human Recombinant Protein Products:

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	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

CEBPD for ontologies About GeneDecksing

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CEBPD for domains About GeneDecksing

2 InterPro domains/families:

IPR004827 bZIP

IPR016468 CCAAT/enhancer-binding

Graphical View of Domain Structure for InterPro Entry P49716

ProtoNet protein and cluster: P49716

UniProtKB/Swiss-Prot: CEBPD_HUMAN, P49716

Similarity: Belongs to the bZIP family. C/EBP subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CEBPD_HUMAN, P49716

Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many

promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the

regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the

several genes associated with activation and/or differentiation of macrophages

Genatlas biochemistry entry for CEBPD:

CCAAT enhancer binding protein delta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the

induction of CEBPB and PPARG,required for adipocyte differentiation.

miRNA Products:		OriGene 3'-UTR Clone: CEBPD Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEBPD
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPD (see all 21):
		hsa-miR-3607-3p hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CEBPD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEBPD (see all 7) OriGene shRNA RFP: CEBPD OriGene siRNA: CEBPD
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CEBPD

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		GenScript: all cDNA clones in your preferred vector: CEBPD (NM_005195)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CEBPD
		Search LifeMap BioReagents cell lines for CEBPD

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CEBPD

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0043565	sequence-specific DNA binding	IEA	--
GO:0046983	protein dimerization activity	--	--

CEBPD for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CEBPD:

Decreased Hepatitis C virus re

Decreased Wnt reporter activit

Animal Models:
Mouse knock-outs for CEBPD: Cebpd^tm1Pfj Cebpd^tm1Aki
10 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cebpd):

adipose tissue	behavior/neurological	cellular	endocrine/exocrine gland	homeostasis/metabolism
immune system	integument	mortality/aging	renal/urinary system	respiratory system

CEBPD for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_CNTF receptor signaling

Immune response_IL-6 signaling pathway

0.30

Immune response IL-6 signaling pathway

0.30

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Expression of CEBPD

Expression of CEBPD

1.00

Transcriptional Regulation of White Adipocyte Differentiation

Transcriptional Regulation of White Adipocyte Differentiation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CEBPD

Immune response IL-6 signaling pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CEBPD

Growth Hormone Signaling

2 Cell Signaling Technology (CST) Pathways for CEBPD

	Lymphocyte Signaling
	Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for CEBPD

Immune response IL-6 signaling pathway

5/6 BioSystems Pathways for CEBPD (see all 6)

	Adipogenesis
	Regulation of retinoblastoma protein
	FOXA2 and FOXA3 transcription factor networks
	C-MYB transcription factor network
	IL6-mediated signaling events

3 Reactome Pathways for CEBPD

	Developmental Biology
	Transcriptional Regulation of White Adipocyte Differentiation
	Expression of CEBPD

CEBPD for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CEBPD

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/103 Interacting proteins for CEBPD (P49716^{2, 3} ENSP00000386165⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 103)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEBPG	P53567³, ENSP00000284000⁴	I2D: score=3 STRING: ENSP00000284000
SPI1	P17947³, ENSP00000227163⁴	I2D: score=2 STRING: ENSP00000227163
HDAC4	P56524³, ENSP00000264606⁴	I2D: score=1 STRING: ENSP00000264606
PIAS4	Q8N2W9³, ENSP00000262971⁴	I2D: score=1 STRING: ENSP00000262971
SMAD3	P84022³, ENSP00000332973⁴	I2D: score=1 STRING: ENSP00000332973

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006366	transcription from RNA polymerase II promoter	TAS	8314590

CEBPD for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CEBPD for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEBPD
1 Novoseek chemical compound relationship for CEBPD gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pge2	26.3	1	17636036 (1)

Search CenterWatch for drugs/clinical trials and news about CEBPD

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CEBPD gene:

NM_005195.3

Unigene Cluster for CEBPD:

CCAAT/enhancer binding protein (C/EBP), delta

Hs.440829 [show with all ESTs]

Unigene Representative Sequence: BM924801

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000408965(uc003xqh.1)

miRNA Products:		OriGene 3'-UTR Clone: CEBPD Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEBPD
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPD (see all 21):
		hsa-miR-3607-3p hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-548c-3p

		SwitchGear 3'UTR luciferase reporter plasmid: CEBPD 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEBPD (see all 7) OriGene shRNA RFP: CEBPD OriGene siRNA: CEBPD
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEBPD

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPD (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPD OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CEBPD (NM_005195)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPD
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPD

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEBPD Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEBPD
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPD

Additional cDNA sequence:

BC094715.1 BC105109.1

10 DOTS entries:

DT.100785526 DT.92449056 DT.80102038 DT.95297703 DT.100785541 DT.95113348 DT.92449054 DT.100785527

DT.95355755 DT.95291489

24/93 AceView cDNA sequences (see all 93):

AW612295 NM_005195 BU733419 BM676781 AI189397 F31940 BM719924 CD671572

CD679153 AA165453 CD677498 BM709457 BM127000 F31052 AI948781 BI492857

BQ025214 BI793111 BI964043 AU100369 BM128526 BF928461 BM127589 BV180703

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEBPD expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCACTTTTT

About this image

CEBPD expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/20 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 20)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Adipocytes

Selective marker (cell-identifying gene)

Adipose

Cervical Brown Adipose Depot

Cervical Brown Adipocyte Cells

Adipose

Cervical Brown Adipose Depot

Cervical Committed Brown Preadipocytes

Adipose

Cranial Subcutaneous White Adipose

Preadipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Lumbar Brown Adipose Depot

Lumbar Brown Adipocyte Cells

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

PureStem™ mesenchymal progenitor 7PEND24 (Embryonic Progenitor Cell)

Cartilage, Neural Crest

HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)

Adipose

Cartilage-like cells (Differentiation of s...)

Cartilage

See CEBPD Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEBPD

SOURCE GeneReport for Unigene cluster: Hs.440829

SABiosciences Expression via Pathway-Focused PCR Arrays including CEBPD:

WNT Signaling Targets in human mouse rat

Signal Transduction PathwayFinder in human mouse rat

JAK / STAT Signaling Pathway in human mouse rat

Synaptic Plasticity in human mouse rat

Adipogenesis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEBPD Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPD

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CEBPD

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CEBPD gene from 4/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CEBPD⁶	--	56(a)	1 ↔ 1	GL343207.1(1680007-1681252)
African clawed frog (Xenopus laevis)	Amphibia	AB107220.1²	--	81.26(n)		AB107220.1
zebrafish (Danio rerio)	Actinopterygii	BC045282.1²	--	78.23(n)		140817 BC045282.1
fruit fly (Drosophila melanogaster)	Insecta	slbo⁶	slow border cells	10(a)	1 → many	2R(20219045-20221829)

ENSEMBL Gene Tree for CEBPD (if available)
TreeFam Gene Tree for CEBPD (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CEBPD gene

CEBPA² CEBPB² CEBPE² CEBPG²

2 SIMAP similar genes for CEBPD using alignment to 2 protein entries: CEBPD_HUMAN (see all proteins):

CEBPB CEBPG

CEBPD for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 8 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs183403386^1,2		--	48649139(+)	`GCAGGG/TGCCCC`	1	--	ds500¹		0	--	--	--	--
rs140417096^1,2		--	48649190(+)	`AACAC-/CTTCTGCT`	1	--	ds500¹		0	--	--	--	--
rs146269923^1,2		--	48649310(+)	`CTCCTC/GAGTAG`	1	--	ds500¹		0	--	--	--	--
rs145014264^1,2		--	48649334(+)	`CCCCG-/CCCCCC`	1	--	ds500¹		0	--	--	--	--
rs113665053^1,2	C	--	48649474(+)	`GCAGGC/G/TGCGAT`	1	--	ds500¹		1		CSA	1
rs187895598^1,2		--	48649622(+)	`TAGCTA/GCATCA`	1	--	ut3¹		0	--	--	--	--
rs11539253^1,2	C,H	--	48649634(-)	`TCTTAC/TTCCTG`	1	--	ut3¹		3		NS NA	104
rs15955^1,2	C,F,	--	48649894(-)	`GCCGCC/TGGGAC`	2	A	syn¹		7		MN WA	710
rs34948549^1,2	C,F	--	48649941(-)	`GCCTCC/TGGCAG`	2	R W	mis¹		7		MN NA	412
rs111429750^1,2	C	--	48649972(+)	`TGCTCC/G/TACGCG`	3	V	syn¹		1		CSA	1

HapMap Linkage Disequilibrium report for CEBPD (48649471 - 48651648 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CEBPD: --

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEBPD

DNA2.0 Custom Variant and Variant Library Synthesis for CEBPD

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CEBPD for disorders           About GeneDecksing

OMIM gene information: 116898    OMIM disorders: --

17 diseases for CEBPD:    About MalaCards

acute lymphoblastic leukemia lymphoblastic leukemia acute myeloid leukemia myeloid leukemia

insulin resistance prostate cancer leukemia alzheimer's disease

retinoblastoma meningioma lung cancer prostatitis

breast cancer obesity cholesterol hepatitis

carcinoma

1 disease from the University of Copenhagen DISEASES database for CEBPD:

Myotonic dystrophy

4 Novoseek disease relationships for CEBPD gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
response acute phase	61.3	5	11145170 (1), 15901830 (1), 9439615 (1)
inflammation	0	1	12215492 (1)
tumors	0	1	18753137 (1)
prostate cancer	0	2	11330648 (1), 15930295 (1)

Human Genome Epidemiology (HuGE) Navigator: CEBPD (4 documents)

Export disorders for CEBPD gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CEBPD gene, integrated from 9 sources (see all 89):
(articles sorted by number of sources associating them with CEBPD)

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The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. (PubMed id 8314590)^{1, 2, 9} Cleutjens C.B.... Trapman J. (1993)
Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. (PubMed id 16397300)^{1, 2} Wang J.-M.... Chang W.-C. (2006)
A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. (PubMed id 1741402)^{1, 2} Kinoshita S.... Kishimoto T. (1992)
A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. (PubMed id 1884998)^{1, 3} Williams S.C....Johnson P.F. (1991)
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. (PubMed id 1840554)^{1, 3} Cao Z....McKnight S.L. (1991)
Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. (PubMed id 15901830)^{1, 9} Wang J.M....Chang W.C. (2005)
Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. (PubMed id 18753137)^{1, 9} Ko C.Y....Wang J.M. (2008)
Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. (PubMed id 18370833)^{1, 9} Kaji H....Tanida K. (2008)
Proteasome-mediated CCAAT/enhancer-binding protein delta (C/EBPdelta) degradation is ubiquitin-independent. (PubMed id 17373909)^{1, 9} Zhou S. and Dewille J.W. (2007)
Interleukin-6 and mevastatin regulate plasminogen activator inhibitor-1 through CCAAT/enhancer-binding protein-delta. (PubMed id 15718495)^{1, 9} Dong J....Kitabatake A. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1052	HGNC: 1835	AceView: CEBPD	Ensembl:ENSG00000221869	euGenes: HUgn1052
ECgene: CEBPD	H-InvDB: CEBPD

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CEBPD	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CEBPD gene
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Patent Information for CEBPD gene:
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