Aliases for CEBPD Gene
Aliases for CEBPD Gene
External Ids for CEBPD Gene
- HGNC: 1835
- Entrez Gene: 1052
- Ensembl: ENSG00000221869
- OMIM: 116898
- UniProtKB: P49716
Previous GeneCards Identifiers for CEBPD Gene
- GC08M048640
- GC08M048372
- GC08M048699
- GC08M048812
- GC08M048649
- GC08M044112
Summaries for CEBPD Gene
-
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
GeneCards Summary for CEBPD Gene
CEBPD (CCAAT/Enhancer Binding Protein Delta) is a Protein Coding gene. Diseases associated with CEBPD include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Validated targets of C-MYC transcriptional repression and C-MYB transcription factor network. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is CEBPB.
UniProtKB/Swiss-Prot for CEBPD Gene
-
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPD Gene
Genomics for CEBPD Gene
Regulatory Elements for CEBPD Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH08G047351 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 12.4 | +383.2 | 383245 | 8.2 | ATF1 FOXA2 MLX YY1 ZNF121 FOS SP5 PPARG ZNF592 PBX2 | CEBPD SPIDR MCM4 LOC100420054 RPL10AP2 PIR60563 GC08M047258 |
| GH08G047506 | 1.5 | Ensembl ENCODE dbSUPER | 11.2 | +227.9 | 227948 | 10.3 | HDGF PKNOX1 ATF1 WRNIP1 SIN3A BRCA1 ZNF48 YY1 GATA2 FOS | SPIDR CEBPD MCM4 RPL29P19 ATP6V1G1P2 LOC100420054 PIR56974 |
| GH08G047675 | 1.4 | Ensembl ENCODE dbSUPER | 11.1 | +62.4 | 62386 | 2.6 | SIN3A INSM2 RAD21 ZEB1 ZNF335 ZNF766 GLIS2 ZNF366 GATA2 FOS | CEBPD SPIDR RNU6-665P PIR54596 |
| GH08G047682 | 1 | Ensembl ENCODE dbSUPER | 10.9 | +55.9 | 55907 | 0.5 | ZFHX2 RFX1 PRDM1 ATF2 EGR2 | CEBPD SPIDR RNU6-665P PIR54596 |
| GH08G047604 | 0.9 | ENCODE dbSUPER | 11.1 | +133.6 | 133607 | 1.1 | CTCF SMAD5 RAD21 EP300 POLR2A IKZF1 ZNF143 SMC3 RELB IKZF2 | CEBPD SPIDR MCM4 GC08P047613 LOC100507422 |
- Transcription factor binding sites by QIAGEN in the CEBPD gene promoter:
Regulatory Element Products
Genomic Location for CEBPD Gene
- Chromosome:
- 8
- Start:
- 47,736,909 bp from pter
- End:
- 47,739,086 bp from pter
- Size:
- 2,178 bases
- Orientation:
- Minus strand
Genomic View for CEBPD Gene
- Cytogenetic band:
-
- 8q11.21 by Ensembl
- 8q11.21 by Entrez Gene
- 8q11.21 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CEBPD Gene
Proteins for CEBPD Gene
-
Protein details for CEBPD Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P49716-CEBPD_HUMAN
- Recommended name:
- CCAAT/enhancer-binding protein delta
- Protein Accession:
- P49716
- Q14937
- Q2M2X9
Protein attributes for CEBPD Gene
- Size:
- 269 amino acids
- Molecular mass:
- 28467 Da
- Quaternary structure:
-
- Binds DNA as a homodimer and as a heterodimer (PubMed:1741402). Can form stable heterodimers with CEBPB (PubMed:1741402). Can form stable heterodimers with CEBPA and CEBPE. Interacts with SPI1/PU.1. Interacts with PRDM16.
Protein Expression for CEBPD Gene
Post-translational modifications for CEBPD Gene
Other Protein References for CEBPD Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
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-
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Assay Products
- antibodies-online Kits for CEBPD: See all 9
No data available for DME Specific Peptides for CEBPD Gene
Domains & Families for CEBPD Gene
Gene Families for CEBPD Gene
Protein Domains for CEBPD Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CEBPD Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P49716- Family:
-
- Belongs to the bZIP family. C/EBP subfamily.
Function for CEBPD Gene
Molecular function for CEBPD Gene
- GENATLAS Biochemistry:
- CCAAT enhancer binding protein delta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction of CEBPB and PPARG,required for adipocyte differentiation.
- UniProtKB/Swiss-Prot Function:
- Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding | IEA | -- |
| GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | transcription factor activity, sequence-specific DNA binding | IEA | -- |
| GO:0005515 | protein binding | IPI | 20102225 |
Phenotypes for CEBPD Gene
- MGI mutant phenotypes for CEBPD:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for CEBPD:
-
- Decreased hepcidin::fluc mRNA expression
- Decreased viability in esophageal squamous lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Resistant to vaccinia virus (VACV-A4L) infection
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Downregulation of Wnt pathway after Wnt3A stimulation
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased Hepatitis C virus replication
- Increased Nanog expression
Animal Model Products
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CRISPR Products
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miRNA for CEBPD Gene
- miRTarBase miRNAs that target CEBPD
-
- hsa-mir-98-5p (MIRT027592)
- hsa-mir-421 (MIRT453683)
- hsa-mir-4709-5p (MIRT453684)
- hsa-mir-4433a-3p (MIRT453685)
- hsa-mir-3668 (MIRT453686)
- hsa-mir-4662b (MIRT453687)
- hsa-mir-4647 (MIRT453688)
- hsa-mir-4426 (MIRT453689)
- hsa-mir-3591-5p (MIRT453690)
- hsa-mir-4460 (MIRT453691)
- hsa-mir-4727-3p (MIRT453692)
- hsa-mir-876-3p (MIRT453693)
- hsa-mir-323a-5p (MIRT453694)
- hsa-mir-103a-2-5p (MIRT453695)
- hsa-mir-3137 (MIRT453696)
- hsa-mir-6872-5p (MIRT453697)
- hsa-mir-6814-3p (MIRT453698)
- hsa-mir-4673 (MIRT453699)
- hsa-mir-4645-5p (MIRT453700)
- hsa-mir-140-5p (MIRT453701)
- hsa-mir-6718-5p (MIRT453702)
- hsa-mir-203b-5p (MIRT453703)
- hsa-mir-1228-3p (MIRT643978)
- hsa-mir-6516-5p (MIRT713042)
- hsa-mir-455-3p (MIRT713043)
- hsa-mir-4999-3p (MIRT713044)
miRNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for CEBPD gene
-
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CEBPD Gene
Localization for CEBPD Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEBPD Gene
- Nucleus.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for CEBPD Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-17 Family Signaling Pathways | ||
| 2 | Cytokine Signaling in Immune system | ||
| 3 | Glucose / Energy Metabolism | ||
| 4 | NF-kappaB Signaling | ||
| 5 | IL-2 Pathway | ||
Pathways by source for CEBPD Gene
2 Cell Signaling Technology pathways for CEBPD Gene
9 BioSystems pathways for CEBPD Gene
6 Reactome pathways for CEBPD Gene
1 GeneGo (Thomson Reuters) pathway for CEBPD Gene
1 R&D Systems pathway for CEBPD Gene
1 Qiagen pathway for CEBPD Gene
Interacting Proteins for CEBPD Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002244 | hematopoietic progenitor cell differentiation | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription from RNA polymerase II promoter | IEA | -- |
| GO:0006366 | transcription from RNA polymerase II promoter | TAS | 8314590 |
Transcripts for CEBPD Gene
mRNA/cDNA for CEBPD Gene
- (1) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (93) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for CEBPD Gene
CRISPR Products
-
OriGene CRISPR knockouts for CEBPD
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miRNA Products
- Search ViGene Biosciences for CEBPD
Inhibitory RNA Products
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Clone Products
-
OriGene ORF clones in human for CEBPD
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- VectorBuilder custom plasmid, inducible vectors for CEBPD
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPD
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for CEBPD Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Adipose (Muscoskeletal System)
- Subcutaneous White Preadipocytes Subcutaneous White Adipose
- Subcutaneous White Preadipocytes Facial Subcutaneous White Adipose
- Preadipocytes Cranial Subcutaneous White Adipose
- Subcutaneous White Adipocytes Subcutaneous White Adipose
- Lumbar Brown Adipocyte Cells Lumbar Brown Adipose Depot
-
Blood (Hematopoietic System)
- Monocytes Peripheral Blood
-
Eye (Sensory Organs)
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Epithelial Cells
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Peripheral Nervous System (Nervous System)
- Schwann Precursor Cells Peripheral Nerve Domain
- Heart (Cardiovascular System)
- Lung (Respiratory System)
-
Kidney (Urinary System)
-
Ovary (Reproductive System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEBPD Gene
NURSA nuclear receptor signaling pathways regulating expression of CEBPD Gene:
CEBPDSOURCE GeneReport for Unigene cluster for CEBPD Gene:
Hs.440829Evidence on tissue expression from TISSUES for CEBPD Gene
- Kidney(4.7)
- Nervous system(4.7)
- Lung(4.6)
- Liver(3.6)
- Muscle(3.4)
- Blood(2.8)
- Intestine(2.8)
- Heart(2.6)
- Eye(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for CEBPD
-
OriGene qPCR primer pairs for CEBPD
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEBPD Gene
Orthologs for CEBPD Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CEBPD 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CEBPD 34 |
|
||
| dog (Canis familiaris) |
Mammalia | CEBPD 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Cebpd 34 16 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Cebpd 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | CEBPD 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | CEBPD 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | CEBPD 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | cebpd 34 |
|
||
| Str.2213 34 |
|
||||
| zebrafish (Danio rerio) |
Actinopterygii | cebpd 34 35 |
|
||
| -- 34 |
|
||||
| worm (Caenorhabditis elegans) |
Secernentea | cebp-2 35 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToMany |
- Species where no ortholog for CEBPD was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for CEBPD Gene
Variants for CEBPD Gene
| SNP ID | Clin | Chr 08 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000925679 | -- | 47,738,417(+) | GCCCG(A/G)GCCGG | upstream-variant-2KB | |
| rs1000988488 | -- | 47,738,875(+) | TGCGT(C/T)CTGGC | upstream-variant-2KB | |
| rs1002346085 | -- | 47,738,941(+) | CACGA(-/CACCGC)GTCCT | upstream-variant-2KB | |
| rs1002377249 | -- | 47,738,675(+) | GCCCC(A/G)CGCCT | upstream-variant-2KB | |
| rs1002417459 | -- | 47,737,165(+) | CCAGG(C/G)TGTAG | utr-variant-3-prime |
Relevant External Links for CEBPD Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CEBPD
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CEBPD Gene
Disorders for CEBPD Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| leukoencephalopathy with vanishing white matter |
|
|
Relevant External Links for CEBPD
No data available for UniProtKB/Swiss-Prot and Genatlas for CEBPD Gene
Publications for CEBPD Gene
- Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. (PMID: 18370833) Kaji H. … Tanida K. (Metab Syndr Relat Disord 2008) 3 22 46 64
- The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. (PMID: 8314590) Cleutjens C.B. … Trapman J. (Genomics 1993) 3 4 22 64
- CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (PMID: 20460359) Bennett C.E. … Carter A.M. (Diab Vasc Dis Res 2010) 3 46 64
- Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 46 64
- Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. (PMID: 18753137) Ko C.Y. … Wang J.M. (J. Biol. Chem. 2008) 3 22 64
Products for CEBPD Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEBPD
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CEBPD Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
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