Aliases for CEBPD Gene
External Ids for CEBPD Gene
Previous GeneCards Identifiers for CEBPD Gene
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
GeneCards Summary for CEBPD Gene
CEBPD (CCAAT/Enhancer Binding Protein Delta) is a Protein Coding gene. Diseases associated with CEBPD include Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Transcription factor regulation in adipogenesis and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is CEBPE.
UniProtKB/Swiss-Prot for CEBPD Gene
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).