Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEBPD Gene

Aliases for CEBPD Gene

  • CCAAT/Enhancer Binding Protein (C/EBP), Delta 2 3
  • Nuclear Factor NF-IL6-Beta 3 4
  • C/EBP Delta 3 4
  • NF-IL6-Beta 3 4
  • CCAAT/Enhancer-Binding Protein Delta 3
  • C/EBP-Delta 3
  • CRP3 3
  • CELF 3

External Ids for CEBPD Gene

Previous GeneCards Identifiers for CEBPD Gene

  • GC08M048640
  • GC08M048372
  • GC08M048699
  • GC08M048812
  • GC08M048649
  • GC08M044112

Summaries for CEBPD Gene

Entrez Gene Summary for CEBPD Gene

  • The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]

GeneCards Summary for CEBPD Gene

CEBPD (CCAAT/Enhancer Binding Protein (C/EBP), Delta) is a Protein Coding gene. Diseases associated with CEBPD include prostate cancer. Among its related pathways are L1CAM interactions and IL6-mediated signaling events. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CEBPE.

UniProtKB/Swiss-Prot for CEBPD Gene

  • C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages

Gene Wiki entry for CEBPD Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPD Gene

Genomics for CEBPD Gene

Regulatory Elements for CEBPD Gene

Genomic Location for CEBPD Gene

Start:
47,736,909 bp from pter
End:
47,739,086 bp from pter
Size:
2,178 bases
Orientation:
Minus strand

Genomic View for CEBPD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEBPD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPD Gene

Proteins for CEBPD Gene

  • Protein details for CEBPD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P49716-CEBPD_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein delta
    Protein Accession:
    P49716
    Secondary Accessions:
    • Q14937
    • Q2M2X9

    Protein attributes for CEBPD Gene

    Size:
    269 amino acids
    Molecular mass:
    28467 Da
    Quaternary structure:
    • Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1. Interacts with PRDM16 (By similarity).

neXtProt entry for CEBPD Gene

Proteomics data for CEBPD Gene at MOPED

Post-translational modifications for CEBPD Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEBPD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPD Gene

Domains for CEBPD Gene

Gene Families for CEBPD Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CEBPD Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEBPD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P49716

UniProtKB/Swiss-Prot:

CEBPD_HUMAN :
  • P49716
Domain:
  • Contains 1 bZIP (basic-leucine zipper) domain.
Family:
  • Belongs to the bZIP family. C/EBP subfamily.
genes like me logo Genes that share domains with CEBPD: view

Function for CEBPD Gene

Molecular function for CEBPD Gene

GENATLAS Biochemistry: CCAAT enhancer binding protein delta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction of CEBPB and PPARG,required for adipocyte differentiation.
UniProtKB/Swiss-Prot Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages

Gene Ontology (GO) - Molecular Function for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0043565 sequence-specific DNA binding --
genes like me logo Genes that share ontologies with CEBPD: view
genes like me logo Genes that share phenotypes with CEBPD: view

Animal Models for CEBPD Gene

MGI Knock Outs for CEBPD:

Animal Model Products

CRISPR Products

miRNA for CEBPD Gene

miRTarBase miRNAs that target CEBPD

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CEBPD Gene

Localization for CEBPD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPD Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEBPD Gene COMPARTMENTS Subcellular localization image for CEBPD gene
Compartment Confidence
nucleus 5
cytosol 2
peroxisome 2
extracellular 1

Gene Ontology (GO) - Cellular Components for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CEBPD: view

Pathways for CEBPD Gene

genes like me logo Genes that share pathways with CEBPD: view

Pathways by source for CEBPD Gene

1 GeneGo (Thomson Reuters) pathway for CEBPD Gene
1 R&D Systems pathway for CEBPD Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CEBPD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 8314590
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with CEBPD: view

Compounds for CEBPD Gene

(1) Novoseek inferred chemical compound relationships for CEBPD Gene

Compound -log(P) Hits PubMed IDs
pge2 26.3 1
genes like me logo Genes that share compounds with CEBPD: view

Transcripts for CEBPD Gene

mRNA/cDNA for CEBPD Gene

(93) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEBPD Gene

CCAAT/enhancer binding protein (C/EBP), delta:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEBPD

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPD Gene

No ASD Table

Relevant External Links for CEBPD Gene

GeneLoc Exon Structure for
CEBPD
ECgene alternative splicing isoforms for
CEBPD

Expression for CEBPD Gene

mRNA expression in normal human tissues for CEBPD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEBPD Gene

SOURCE GeneReport for Unigene cluster for CEBPD Gene Hs.440829

genes like me logo Genes that share expressions with CEBPD: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CEBPD Gene

Orthologs for CEBPD Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEBPD 35
  • 99.5 (n)
  • 99.26 (a)
CEBPD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CEBPD 35
  • 88.02 (n)
  • 89.84 (a)
dog
(Canis familiaris)
Mammalia CEBPD 35
  • 87.52 (n)
  • 83.41 (a)
mouse
(Mus musculus)
Mammalia Cebpd 35
  • 86.19 (n)
  • 86.19 (a)
Cebpd 16
oppossum
(Monodelphis domestica)
Mammalia CEBPD 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEBPD 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cebpd 35
  • 85.07 (n)
  • 87.31 (a)
lizard
(Anolis carolinensis)
Reptilia CEBPD 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpd 35
  • 67.56 (n)
  • 63.39 (a)
Str.2213 35
zebrafish
(Danio rerio)
Actinopterygii -- 35
cebpd 35
  • 61.41 (n)
  • 56.43 (a)
cebpd 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cebp-2 36
  • 26 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 22 (a)
OneToMany
Species with no ortholog for CEBPD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPD Gene

ENSEMBL:
Gene Tree for CEBPD (if available)
TreeFam:
Gene Tree for CEBPD (if available)

Paralogs for CEBPD Gene

Paralogs for CEBPD Gene

Selected SIMAP similar genes for CEBPD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CEBPD: view

Variants for CEBPD Gene

Sequence variations from dbSNP and Humsavar for CEBPD Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs15955 -- 47,737,332(-) GCCGC(C/T)GGGAC reference, synonymous-codon
rs11539253 -- 47,737,072(-) TCTTA(C/T)TCCTG utr-variant-3-prime
rs11539254 -- 47,737,471(-) CAACC(A/T)GGAGA reference, missense
rs11539255 -- 47,737,449(-) TTGGT(G/T)GAGCT reference, synonymous-codon
rs34093480 -- 47,736,896(+) CTGCG(-/A)AATAT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CEBPD Gene

Variant ID Type Subtype PubMed ID
nsv890849 CNV Loss 21882294

Relevant External Links for CEBPD Gene

HapMap Linkage Disequilibrium report
CEBPD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEBPD Gene

Disorders for CEBPD Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CEBPD Gene including...

Search for CEBPD Gene in MalaCards »

(2) University of Copenhagen DISEASES for CEBPD Gene

(4) Novoseek inferred disease relationships for CEBPD Gene

Disease -log(P) Hits PubMed IDs
response acute phase 61.3 3
inflammation 0 1
tumors 0 1
prostate cancer 0 2

Relevant External Links for CEBPD

Genetic Association Database (GAD)
CEBPD
Human Genome Epidemiology (HuGE) Navigator
CEBPD
genes like me logo Genes that share disorders with CEBPD: view

No data available for UniProtKB/Swiss-Prot for CEBPD Gene

Publications for CEBPD Gene

  1. The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. (PMID: 8314590) Cleutjens C.B. … Trapman J. (Genomics 1993) 3 4 23
  2. Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. (PMID: 18370833) Kaji H. … Tanida K. (Metab Syndr Relat Disord 2008) 3 23 48
  3. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. (PMID: 18753137) Ko C.Y. … Wang J.M. (J. Biol. Chem. 2008) 3 23
  4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PMID: 18660489) Lu Y. … Boer J.M. (J. Lipid Res. 2008) 3 48
  5. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. (PMID: 1741402) Kinoshita S. … Kishimoto T. (Proc. Natl. Acad. Sci. U.S.A. 1992) 3 4

Products for CEBPD Gene

Sources for CEBPD Gene

Back to Top

Content