Aliases for CEBPD Gene
External Ids for CEBPD Gene
Previous GeneCards Identifiers for CEBPD Gene
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
GeneCards Summary for CEBPD Gene
CEBPD (CCAAT/Enhancer Binding Protein Delta) is a Protein Coding gene. Diseases associated with CEBPD include cardiomyopathy, dilated, 1m and cardiomyopathy, hypertrophic, 12. Among its related pathways are IL6-mediated signaling events and Regulation of retinoblastoma protein. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and RNA polymerase II core promoter proximal region sequence-specific DNA binding. An important paralog of this gene is CEBPE.
UniProtKB/Swiss-Prot for CEBPD Gene
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402).