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CEBPD Gene

protein-coding   GIFtS: 61
GCID: GC08M048649

CCAAT/Enhancer Binding Protein (C/EBP), Delta

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Delta1 2     C/EBP-delta2
C/EBP Delta2 3     CELF2
Nuclear Factor NF-IL6-Beta2 3     CRP32
NF-IL6-beta2 3     CCAAT/Enhancer-Binding Protein Delta2

External Ids:    HGNC: 18351   Entrez Gene: 10522   Ensembl: ENSG000002218697   OMIM: 1168985   UniProtKB: P497163   

Export aliases for CEBPD gene to outside databases

Previous GC identifers: GC08M047759 GC08M048640 GC08M048372 GC08M048699 GC08M048812 GC08M044112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEBPD Gene:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to
certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded
protein is important in the regulation of genes involved in immune and inflammatory responses, and may be
involved in the regulation of genes associated with activation and/or differentiation of macrophages. The
cytogenetic location of this locus has been reported as both 8p11 and 8q11. (provided by RefSeq, Sep 2010)

GeneCards Summary for CEBPD Gene:
CEBPD (CCAAT/enhancer binding protein (C/EBP), delta) is a protein-coding gene. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CEBPA.

UniProtKB/Swiss-Prot: CEBPD_HUMAN, P49716
Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many
promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the
regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation
of the several genes associated with activation and/or differentiation of macrophages

Gene Wiki entry for CEBPD Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NC_018919.2  NT_008183.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEBPD gene promoter:
         GR   TBP   AP-1   ATF-2   TFIID   STAT3   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEBPD promoter sequence
   Search Chromatin IP Primers for CEBPD

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEBPD


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p11.2-p11.1   Ensembl cytogenetic band:  8q11.21   HGNC cytogenetic band: 8p11.2-p11.1

CEBPD Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPD gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M048649:  view genomic region     (about GC identifiers)

Start:
48,649,471 bp from pter      End:
48,651,648 bp from pter
Size:
2,178 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CEBPD_HUMAN, P49716 (See protein sequence)
Recommended Name: CCAAT/enhancer-binding protein delta  
Size: 269 amino acids; 28467 Da
Subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha. Interacts with SPI1/PU.1.
Interacts with PRDM16 (By similarity)
Secondary accessions: Q14937 Q2M2X9

Explore the universe of human proteins at neXtProt for CEBPD: NX_P49716

Explore proteomics data for CEBPD at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CEBPD Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005186.2  
    ENSEMBL proteins: 
     ENSP00000386165  
    Reactome Protein details: P49716

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    Browse Sino Biological Cell Lysates
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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CEBPD (3 products) 

     
    antibodies-online peptides for CEBPD

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR016468 CCAAT/enhancer-binding

    Graphical View of Domain Structure for InterPro Entry P49716

    ProtoNet protein and cluster: P49716

    UniProtKB/Swiss-Prot: CEBPD_HUMAN, P49716
    Similarity: Belongs to the bZIP family. C/EBP subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with CEBPD           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEBPD_HUMAN, P49716
    Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many
    promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the
    regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation
    of the several genes associated with activation and/or differentiation of macrophages

         Genatlas biochemistry entry for CEBPD:
    CCAAT enhancer binding protein delta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the
    induction of CEBPB and PPARG,required for adipocyte differentiation.

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding IEA--
         
    Find genes that share ontologies with CEBPD           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CEBPD:
     Decreased Hepatitis C virus re  Decreased Wnt reporter activit 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cebpd):
     adipose tissue  behavior/neurological  cellular  endocrine/exocrine gland  homeostasis/metabolism 
     immune system  integument  mortality/aging  renal/urinary system  respiratory system 

    Find genes that share phenotypes with CEBPD           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CEBPD: Cebpdtm1Pfj Cebpdtm1Aki

       genOway: Develop your customized and physiologically relevant rodent model for CEBPD

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    miRTarBase miRNAs that target CEBPD:
    hsa-mir-98-5p (MIRT027592)

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    Selected qRT-PCR Assays for microRNAs that regulate CEBPD (see all 21):
    hsa-miR-3607-3p hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCEBPD 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CEBPD

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEBPD_HUMAN, P49716: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    peroxisome2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    Find genes that share ontologies with CEBPD           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEBPD About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    IL17 signaling pathway0.51
    2L1CAM interactions
    Developmental Biology0.63
    3ErbB4 Pathway
    Growth Hormone Signaling0.49
    4Fatty acid, triacylglycerol, and ketone body metabolism
    Transcriptional Regulation of White Adipocyte Differentiation0.38
    5Validated targets of C-MYC transcriptional repression
    Validated targets of C-MYC transcriptional repression


    Find genes that share SuperPaths with CEBPD           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CEBPD
        IL-17 Family Signaling Pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CEBPD
        Growth Hormone Signaling

    2 Cell Signaling Technology (CST) Pathways for CEBPD
        Lymphocyte Signaling
    Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for CEBPD
        Immune response IL-6 signaling pathway

    Selected BioSystems Pathways for CEBPD (see all 7)
        Adipogenesis
    IL17 signaling pathway
    IL6-mediated signaling events
    C-MYB transcription factor network
    Regulation of retinoblastoma protein

    1 Reactome Pathway for CEBPD
        Transcriptional regulation of white adipocyte differentiation


        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPD: 
              WNT Signaling Targets in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat
              Adipogenesis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CEBPD

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CEBPD (P497162, 3 ENSP000003861654) via UniProtKB, MINT, STRING, and/or I2D (see all 152)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000228881Q128993, ENSP000004153284I2D: score=1 STRING: ENSP00000415328
    ENSG00000137313Q128993I2D: score=1 
    ENSG00000226060Q128993I2D: score=1 
    ENSG00000230230Q128993I2D: score=1 
    ENSG00000231002Q128993I2D: score=1 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS8314590

    Find genes that share ontologies with CEBPD           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEBPD

    1 Novoseek inferred chemical compound relationship for CEBPD gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pge2 26.3 1 17636036 (1)



    Find genes that share compounds with CEBPD           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CEBPD gene: 
    NM_005195.3  

    Unigene Cluster for CEBPD:

    CCAAT/enhancer binding protein (C/EBP), delta
    Hs.440829  [show with all ESTs]
    Unigene Representative Sequence: BM924801
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000408965(uc003xqh.1)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CEBPD (see all 21):
    hsa-miR-3607-3p hsa-miR-520d-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-let-7a hsa-miR-548c-3p
    SwitchGear 3'UTR luciferase reporter plasmidCEBPD 3' UTR sequence
    Inhib. RNA
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    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat CEBPD
      QuantiFast Probe-based Assays in human, mouse, rat CEBPD

    Additional mRNA sequence: 

    BC094715.1 BC105109.1 

    10 DOTS entries:

    DT.100785526  DT.92449056  DT.80102038  DT.95297703  DT.100785541  DT.95113348  DT.92449054  DT.100785527 
    DT.95355755  DT.95291489 

    Selected AceView cDNA sequences (see all 93):

    AW612295 AA165453 F31940 BU733419 BM709457 CD679153 BM676781 BM719924 
    CD677498 AI189397 NM_005195 CD671572 BQ025214 BI492526 AU100369 BM127589 
    BI793111 BP382272 AI948781 BI964043 BX324724 F31052 BM127000 AA165640 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEBPD expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCACTTTTT
    CEBPD Expression
    About this image


    CEBPD expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 9) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 20 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
     
     Epithelial Cells
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Eye (Sensory Organs)
             Limbal Basal Epithelial Cells Limbus Epithelium
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Monocytes Peripheral Blood
     
     Peripheral Nervous System (Nervous System)
             Schwann Precursor Cells Peripheral Nerve Domain
    CEBPD Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEBPD Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.440829
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPD: 
              WNT Signaling Targets in human mouse rat
              Signal Transduction PathwayFinder in human mouse rat
              JAK / STAT Signaling Pathway in human mouse rat
              Synaptic Plasticity in human mouse rat
              Adipogenesis in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat CEBPD
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPD

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CEBPD gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cebpd1 , 5 CCAAT/enhancer binding protein (C/EBP), delta1, 5 86.19(n)1
    86.19(a)1
      16 (10.09 cM)5
    126091  NM_007679.41  NP_031705.31 
     158872865 
    lizard
    (Anolis carolinensis)
    Reptilia CEBPD6
    CCAAT/enhancer binding protein (C/EBP), delta
    54(a)
    1 ↔ 1
    GL343207.1(1680007-1681252)
    African clawed frog
    (Xenopus laevis)
    Amphibia AB107220.12   -- 81.26(n)    AB107220.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC045282.12   -- 78.23(n)   140817  BC045282.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cebp-26
    Protein CEBP-2 (cebp-2) mRNA, complete cds
    26(a)
    1 → many
    I(6253019-6253583) WBGene00016754


    ENSEMBL Gene Tree for CEBPD (if available)
    TreeFam Gene Tree for CEBPD (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEBPD gene
    CEBPA2  CEBPB2  CEBPE2  CEBPG2  
    2 SIMAP similar genes for CEBPD using alignment to 2 protein entries:     CEBPD_HUMAN (see all proteins):
    CEBPB    CEBPG

    Find genes that share paralogs with CEBPD           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEBPD (see all 53)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1834033861,2
    --48649139(+) GCAGGG/TGCCCC 1 -- ds50010--------
    rs1404170961,2
    C--48649190(+) AACAC-/CTTCTGCT 1 -- ds50010--------
    rs1462699231,2
    --48649310(+) CTCCTC/GAGTAG 1 -- ds50010--------
    rs1450142641,2
    C--48649340(+) CCCCG-/CCCCCC 1 -- ds50010--------
    rs1136650531,2
    C--48649474(+) GCAGGC/G/TGCGAT 1 -- ds50011CSA 1
    rs1878955981,2
    --48649622(+) TAGCTA/GCATCA 1 -- ut310--------
    rs115392531,2
    C,H--48649634(-) TCTTAC/TTCCTG 1 -- ut313Minor allele frequency- T:0.01NS NA 104
    rs159551,2
    C,F--48649894(-) GCCGCC/TNGGAC 2 A syn17Minor allele frequency- T:0.02MN WA 710
    rs349485491,2,,4
    C,F--48649941(-) GCCTCC/TGGCAG 2 R W mis17Minor allele frequency- T:0.01MN NA 412
    rs1114297501,2
    C--48649972(+) TGCTCC/G/TACGCG 3 V syn11CSA 1

    HapMap Linkage Disequilibrium report for CEBPD (48649471 - 48651648 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CEBPD:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv890849CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CEBPD
    DNA2.0 Custom Variant and Variant Library Synthesis for CEBPD

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116898    OMIM disorders: --

    2 diseases from the University of Copenhagen DISEASES database for CEBPD:
    Myotonic dystrophy     Barrett's esophagus

    Find genes that share disorders with CEBPD           About GenesLikeMe

    4 Novoseek inferred disease relationships for CEBPD gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 61.3 5 11145170 (1), 15901830 (1), 9439615 (1)
    inflammation 0 1 12215492 (1)
    tumors 0 1 18753137 (1)
    prostate cancer 0 2 11330648 (1), 15930295 (1)

    Genetic Association Database (GAD): CEBPD
    Human Genome Epidemiology (HuGE) Navigator: CEBPD (4 documents)

    Export disorders for CEBPD gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEBPD gene, integrated from 10 sources (see all 99):
    (articles sorted by number of sources associating them with CEBPD)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variations at the CCAAT/enhancer-binding protein delta are associated with metabolic phenotypes in the Japanese population. (PubMed id 18370833)1, 4, 9 Kaji H....Tanida K. (Metab Syndr Relat Disord 2008)
    2. The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization. (PubMed id 8314590)1, 2, 9 Cleutjens C.B.... Trapman J. (Genomics 1993)
    3. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (PubMed id 20460359)1, 4 Bennett C.E....Carter A.M. (amp 2010)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    5. Functional role of NF-IL6beta and its sumoylation and acetylation modifications in promoter activation of cyclooxygenase 2 gene. (PubMed id 16397300)1, 2 Wang J.-M.... Chang W.-C. (Nucleic Acids Res. 2006)
    6. A member of the C/EBP family, NF-IL6 beta, forms a heterodimer and transcriptionally synergizes with NF-IL6. (PubMed id 1741402)1, 2 Kinoshita S.... Kishimoto T. (Proc. Natl. Acad. Sci. U.S.A. 1992)
    7. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. (PubMed id 1884998)1, 3 Williams S.C....Johnson P.F. (amp 1991)
    8. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. (PubMed id 1840554)1, 3 Cao Z....McKnight S.L. (amp 1991)
    9. Induction of human NF-IL6beta by epidermal growth factor is mediated through the p38 signaling pathway and cAMP response element-binding protein activation in A431 cells. (PubMed id 15901830)1, 9 Wang J.M....Chang W.C. (Mol. Biol. Cell 2005)
    10. Epigenetic silencing of CCAAT/enhancer-binding protein delta activity by YY1/polycomb group/DNA methyltransferase complex. (PubMed id 18753137)1, 9 Ko C.Y....Wang J.M. (J. Biol. Chem. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1052 HGNC: 1835 AceView: CEBPD Ensembl:ENSG00000221869 euGenes: HUgn1052
    ECgene: CEBPD H-InvDB: CEBPD

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CEBPD Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CEBPD gene:
    Search GeneIP for patents involving CEBPD

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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