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Aliases for CEBPB Gene

Aliases for CEBPB Gene

  • CCAAT/Enhancer Binding Protein (C/EBP), Beta 2 3
  • TCF5 3 4 6
  • Interleukin 6-Dependent DNA-Binding Protein 2 3
  • Nuclear Factor Of Interleukin 6 2 3
  • Transcription Factor 5 3 4
  • Nuclear Factor NF-IL6 3 4
  • Liver-Enriched Transcriptional Activator Protein 2
  • CCAAT/Enhancer-Binding Protein Beta 3
  • Liver-Enriched Inhibitory Protein 4
  • Liver Activator Protein 4
  • C/EBP-Beta 3
  • C/EBP Beta 4
  • IL6DBP 3
  • NF-IL6 3
  • TCF-5 4
  • LAP 4
  • LIP 4

External Ids for CEBPB Gene

Previous Symbols for CEBPB Gene

  • TCF5

Summaries for CEBPB Gene

Entrez Gene Summary for CEBPB Gene

  • This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]

GeneCards Summary for CEBPB Gene

CEBPB (CCAAT/Enhancer Binding Protein (C/EBP), Beta) is a Protein Coding gene. Among its related pathways are L1CAM interactions and ERK Signaling. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is CEBPE.

UniProtKB/Swiss-Prot for CEBPB Gene

  • Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5-T[TG]NNGNAA[TG]-3. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).

  • Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.

  • Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).

Gene Wiki entry for CEBPB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEBPB Gene

Genomics for CEBPB Gene

Genomic Location for CEBPB Gene

Start:
50,190,583 bp from pter
End:
50,192,690 bp from pter
Size:
2,108 bases
Orientation:
Plus strand

Genomic View for CEBPB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEBPB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEBPB Gene

Regulatory Elements for CEBPB Gene

Proteins for CEBPB Gene

  • Protein details for CEBPB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17676-CEBPB_HUMAN
    Recommended name:
    CCAAT/enhancer-binding protein beta
    Protein Accession:
    P17676
    Secondary Accessions:
    • A8K671
    • Q96IH2
    • Q9H4Z5

    Protein attributes for CEBPB Gene

    Size:
    345 amino acids
    Molecular mass:
    36106 Da
    Quaternary structure:
    • Binds DNA as a dimer and can form stable heterodimers with CEBPA, CEBPD and CEBPG. Isoform 2 and isoform 3 also form heterodimers. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5. Interacts with ZNF638; this interaction increases transcriptional activation. Interacts with CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target genes. Interacts with DDIT3/CHOP.Interacts with EP300; recruits EP300 to chromatin. Interacts with RORA; the interaction disrupts interaction with EP300. Interacts (not methylated) with MED23, MED26, SMARCA2, SMARCB1 and SMARCC1 (PubMed:20111005). Interacts with KAT2A and KAT2B (By similarity).

    Three dimensional structures from OCA and Proteopedia for CEBPB Gene

    Alternative splice isoforms for CEBPB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEBPB Gene

Proteomics data for CEBPB Gene at MOPED

Post-translational modifications for CEBPB Gene

  • Acetylated. Acetylation at Lys-43 is an important and dynamic regulatory event that contributes to its ability to transactivate target genes, including those associated with adipogenesis and adipocyte function. Deacetylation by HDAC1 represses its transactivation activity. Acetylated by KAT2A and KAT2B within a cluster of lysine residues between amino acids 129-133, this acetylation is strongly induced by glucocorticoid treatment and enhances transactivation activity.
  • Methylated. Methylation at Arg-3 by CARM1 and at Lys-43 by EHMT2 inhibit transactivation activity. Methylation is probably inhibited by phosphorylation at Thr-235.
  • O-glycosylated, glycosylation at Ser-227 and Ser-228 prevents phosphorylation on Thr-235, Ser-231 and Thr-226 and DNA binding activity which delays the adipocyte differentiation program.
  • Phosphorylated at Thr-235 by MAPK and CDK2, serves to prime phosphorylation at Thr-226 and Ser-231 by GSK3B and acquire DNA-binding as well as transactivation activities, required to induce adipogenesis. MAPK and CDK2 act sequentially to maintain Thr-235 in the primed phosphorylated state during mitotical cloning expansion and thereby progression of terminal differentiation. Phosphorylation at Thr-266 enhances transactivation activity. Phosphorylation at Ser-325 in response to calcium increases transactivation activity. Phosphorylated at Thr-235 by RPS6KA1 (PubMed:11684016).
  • Sumoylated by polymeric chains of SUMO2 or SUMO3 (PubMed:12810706). Sumoylation at Lys-174 is required for inhibition of T-cells proliferation. In adipocytes, sumoylation at Lys-174 by PIAS1 leads to ubiquitination and subsequent proteasomal degradation. Desumoylated by SENP2, which abolishes ubiquitination and stabilizes protein levels (By similarity).
  • Ubiquitinated, leading to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CEBPB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CEBPB Gene

Domains for CEBPB Gene

Gene Families for CEBPB Gene

HGNC:
  • bZIP :basic leucine zipper proteins

Protein Domains for CEBPB Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CEBPB_HUMAN
Domain:
  • the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.:
    • P17676
  • Contains 1 bZIP (basic-leucine zipper) domain.:
    • P17676
Family:
  • Belongs to the bZIP family. C/EBP subfamily.:
    • P17676
genes like me logo Genes that share domains with CEBPB: view

Function for CEBPB Gene

Molecular function for CEBPB Gene

GENATLAS Biochemistry: CCAAT enhancer binding protein beta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction of CEBPA and PPARG,required for adipocyte differentiation.
UniProtKB/Swiss-Prot Function: Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:9374525, PubMed:12048245, PubMed:18647749). Plays also a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5-T[TG]NNGNAA[TG]-3. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant functions with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Plays also a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation (PubMed:20829347). Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis (By similarity).
UniProtKB/Swiss-Prot Function: Isoform 2: Essential for gene expression induction in activated macrophages. Plays a major role in immune responses such as CD4(+) T-cell response, granuloma formation and endotoxin shock. Not essential for intracellular bacteria killing.
UniProtKB/Swiss-Prot Function: Isoform 3: Acts as a dominant negative through heterodimerization with isoform 2 (PubMed:11741938). Promotes osteoblast differentiation and osteoclastogenesis (By similarity).
UniProtKB/Swiss-Prot Induction: By ER stress.

Gene Ontology (GO) - Molecular Function for CEBPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 7959007
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding TAS 10821850
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with CEBPB: view
genes like me logo Genes that share phenotypes with CEBPB: view

Animal Models for CEBPB Gene

MGI Knock Outs for CEBPB:

miRNA for CEBPB Gene

Targeting motifs for CEBPB Gene
HOMER Transcription Factor Regulatory Elements motif CEBPB
  • Consensus sequence: ATTGCGCAAC Submotif: canonical Cell Type: ThioMac GeoId: GSE21512

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targeting for CEBPB Gene

Localization for CEBPB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEBPB Gene

Nucleus. Cytoplasm. Note=Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity). {ECO:0000250 UniProtKB:P28033, ECO:0000269 PubMed:9374525}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEBPB Gene COMPARTMENTS Subcellular localization image for CEBPB gene
Compartment Confidence
nucleus 5
cytosol 2
extracellular 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEBPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000779 condensed chromosome, centromeric region IEA --
GO:0000790 nuclear chromatin IEA --
GO:0005634 nucleus IDA 20829347
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CEBPB: view

Pathways for CEBPB Gene

genes like me logo Genes that share pathways with CEBPB: view

Gene Ontology (GO) - Biological Process for CEBPB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development ISS --
GO:0001892 embryonic placenta development IEA --
GO:0002432 granuloma formation ISS --
GO:0006355 regulation of transcription, DNA-templated IDA 20829347
GO:0006366 transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with CEBPB: view

Compounds for CEBPB Gene

(49) Novoseek inferred chemical compound relationships for CEBPB Gene

Compound -log(P) Hits PubMed IDs
chloramphenicol 54.5 7
amino acid 50.1 2
leucine 42 12
retinoic acid 39.5 16
gp 130 35.6 3
genes like me logo Genes that share compounds with CEBPB: view

Transcripts for CEBPB Gene

mRNA/cDNA for CEBPB Gene

Unigene Clusters for CEBPB Gene

CCAAT/enhancer binding protein (C/EBP), beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEBPB Gene

No ASD Table

Relevant External Links for CEBPB Gene

GeneLoc Exon Structure for
CEBPB
ECgene alternative splicing isoforms for
CEBPB

Expression for CEBPB Gene

mRNA expression in normal human tissues for CEBPB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEBPB Gene

This gene is overexpressed in Whole Blood (8.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEBPB Gene

SOURCE GeneReport for Unigene cluster for CEBPB Gene Hs.517106

mRNA Expression by UniProt/SwissProt for CEBPB Gene

P17676-CEBPB_HUMAN
Tissue specificity: Expressed at low levels in the lung, kidney and spleen
genes like me logo Genes that share expressions with CEBPB: view

Orthologs for CEBPB Gene

This gene was present in the common ancestor of animals.

Orthologs for CEBPB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEBPB 36
  • 99.71 (n)
  • 100 (a)
CEBPB 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEBPB 36
  • 96.71 (n)
  • 96.22 (a)
CEBPB 37
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cebpb 36
  • 83.9 (n)
  • 79.39 (a)
Cebpb 16
Cebpb 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CEBPB 37
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cebpb 36
  • 82.83 (n)
  • 78.79 (a)
chicken
(Gallus gallus)
Aves CEBPB 36
  • 74.81 (n)
  • 70.36 (a)
CEBPB 37
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CEBPB 37
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cebpb 36
  • 73.38 (n)
  • 72.66 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10599 36
zebrafish
(Danio rerio)
Actinopterygii -- 36
cebpb 37
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea cebp-2 37
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 21 (a)
OneToMany
Species with no ortholog for CEBPB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CEBPB Gene

ENSEMBL:
Gene Tree for CEBPB (if available)
TreeFam:
Gene Tree for CEBPB (if available)

Paralogs for CEBPB Gene

Paralogs for CEBPB Gene

Selected SIMAP similar genes for CEBPB Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CEBPB: view

Variants for CEBPB Gene

Sequence variations from dbSNP and Humsavar for CEBPB Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_016300 -

Structural Variations from Database of Genomic Variants (DGV) for CEBPB Gene

Variant ID Type Subtype PubMed ID
esv34129 CNV Loss 18971310
nsv912916 CNV Loss 21882294
nsv828736 CNV Gain 20364138
dgv702n67 CNV Gain 20364138

Relevant External Links for CEBPB Gene

HapMap Linkage Disequilibrium report
CEBPB

Disorders for CEBPB Gene

(34) Novoseek inferred disease relationships for CEBPB Gene

Disease -log(P) Hits PubMed IDs
response acute phase 55.5 8
choriocarcinoma 38.4 1
necrosis 37.8 8
leukemia promyelocytic acute 31.3 3
inflammation 24.9 3

Relevant External Links for CEBPB

Genetic Association Database (GAD)
CEBPB
Human Genome Epidemiology (HuGE) Navigator
CEBPB
genes like me logo Genes that share disorders with CEBPB: view

No data available for UniProtKB/Swiss-Prot for CEBPB Gene

Publications for CEBPB Gene

  1. Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. (PMID: 7635140) Toda K. … Shizuta Y. (Eur. J. Biochem. 1995) 3 4 23
  2. G9a-mediated lysine methylation alters the function of CCAAT/enhancer-binding protein-beta. (PMID: 18647749) Pless O. … Leutz A. (J. Biol. Chem. 2008) 3 4 23
  3. NF-IL6 (C/EBPbeta) induces HIV-1 replication by inhibiting cytidine deaminase APOBEC3G. (PMID: 18809921) Kinoshita S.M. … Taguchi S. (Proc. Natl. Acad. Sci. U.S.A. 2008) 3 23
  4. Intracellular galectin-9 activates inflammatory cytokines in monocytes. (PMID: 19335620) Matsuura A. … Tanaka Y. (Genes Cells 2009) 3 23
  5. Selective activation of trophoblast-specific PLAC1 in breast cancer by CCAAT/enhancer-binding protein beta (C/EBPbeta) isoform 2. (PMID: 19652226) Koslowski M. … Sahin U. (J. Biol. Chem. 2009) 3 23

Products for CEBPB Gene

  • Addgene plasmids for CEBPB

Sources for CEBPB Gene

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