Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CEBPB Gene

protein-coding   GIFtS: 64
GCID: GC20P048807

CCAAT/Enhancer Binding Protein (C/EBP), Beta


(Previous symbol: TCF5)
  See CEBPB-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Beta1 2     IL6DBP2
TCF51 2 3 5     NF-IL62
Interleukin 6-Dependent DNA-Binding Protein1 2     CCAAT/Enhancer-Binding Protein Beta2
Nuclear Factor Of Interleukin 61 2     LAP3
Nuclear Factor NF-IL62 3     LIP3
Transcription Factor 52 3     TCF-53
Liver-Enriched Transcriptional Activator Protein1     C/EBP Beta3
C/EBP-beta2     Liver Activator Protein3
CRP22     Liver-Enriched Inhibitory Protein3

External Ids:    HGNC: 18341   Entrez Gene: 10512   Ensembl: ENSG000001722167   OMIM: 1899655   UniProtKB: P176763   

Export aliases for CEBPB gene to outside databases

Previous GC identifers: GC20P048535 GC20P049445 GC20P049492 GC20P048240 GC20P045555


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CEBPB Gene:
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The
encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins
alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and
inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in
multiple protein isoforms, each with distinct biological functions. (provided by RefSeq, Oct 2013)

GeneCards Summary for CEBPB Gene:
CEBPB (CCAAT/enhancer binding protein (C/EBP), beta) is a protein-coding gene. Diseases associated with CEBPB include acute promyelocytic leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CEBPA.

UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
Function: Important transcriptional activator regulating the expression of genes involved in immune and
inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays
a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is
5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional
induction of peroxisome proliferator-activated receptor gamma (PPARG)
Function: Isoform 3: acts as a dominant negative through heterodimerization with isoform 2

Gene Wiki entry for CEBPB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000020.10  NC_018931.2  NT_011362.11  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEBPB gene promoter:
         GR   CREB   GR-beta   deltaCREB   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEBPB promoter sequence
   Search Chromatin IP Primers for CEBPB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEBPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.1

CEBPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P048807:  view genomic region     (about GC identifiers)

Start:
48,807,376 bp from pter      End:
48,809,212 bp from pter
Size:
1,837 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676 (See protein sequence)
Recommended Name: CCAAT/enhancer-binding protein beta  
Size: 345 amino acids; 36106 Da
Subunit: Binds DNA as a dimer and can form stable heterodimers with CEBPA, CEBPD and CEBPG. Isoform 2 and isoform
3 also form heterodimers. Interacts with TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms
a complex with THOC5 (By similarity). Interacts with ZNF638; this interaction increases transcriptional
activation (By similarity). Interacts with CIDEA and CIDEC; these interactions increase transcriptional
activation of a subset of CEBPB downstream target genes (By similarity). Interacts with DDIT3/CHOP
Selected PDB 3D structures from and Proteopedia for CEBPB (see all 10):
1GTW (3D)        1GU4 (3D)        1GU5 (3D)        1H88 (3D)        1H89 (3D)        1H8A (3D)    
Secondary accessions: A8K671 Q96IH2 Q9H4Z5
Alternative initiation: 3 isoforms:  P17676-1   P17676-2   P17676-3   

Explore the universe of human proteins at neXtProt for CEBPB: NX_P17676

Explore proteomics data for CEBPB at MOPED

Post-translational modifications: 

  • Sumoylated by polymeric chains of SUMO2 or SUMO31
  • Phosphorylated at Thr-235 by RPS6KA11
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CEBPB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001272807.1  NP_001272808.1  NP_005185.2  

    ENSEMBL proteins: 
     ENSP00000305422  
    Reactome Protein details: P17676

    CEBPB Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CEBPB
    OriGene Protein Over-expression Lysate for CEBPB
    OriGene MassSpec for CEBPB
    OriGene Custom Protein Services for CEBPB
    GenScript Custom Purified and Recombinant Proteins Services for CEBPB
    Novus Biologicals CEBPB Proteins
    Novus Biologicals CEBPB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CEBPB 

    CEBPB Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CEBPB
    Browse R&D Systems for Antibodies
    OriGene Antibodies for CEBPB
    OriGene Custom Antibody Services for CEBPB
    Novus Biologicals CEBPB Antibodies
    Abcam antibodies for CEBPB
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CEBPB
    LSBio Antibodies in human, mouse, rat for CEBPB

    CEBPB Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CEBPB
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CEBPB
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CEBPB 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR016468 CCAAT/enhancer-binding

    Graphical View of Domain Structure for InterPro Entry P17676

    ProtoNet protein and cluster: P17676

    UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Belongs to the bZIP family. C/EBP subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Find genes that share domains with CEBPB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEBPB_HUMAN, P17676
    Function: Important transcriptional activator regulating the expression of genes involved in immune and
    inflammatory responses. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays
    a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is
    5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT) differentiation. Regulates the transcriptional
    induction of peroxisome proliferator-activated receptor gamma (PPARG)
    Function: Isoform 3: acts as a dominant negative through heterodimerization with isoform 2
    Induction: By ER stress

         Genatlas biochemistry entry for CEBPB:
    CCAAT enhancer binding protein beta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the
    induction of CEBPA and PPARG,required for adipocyte differentiation.

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding TAS10821850
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10821850
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS--
    GO:0005515protein binding IPI12692227
         
    Find genes that share ontologies with CEBPB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CEBPB:
     Increased cell number in G1, a 

         Selected MGI mutant phenotypes (inferred from 12 alleles(MGI details for Cebpb) (see all 18):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    Find genes that share phenotypes with CEBPB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for CEBPB: Cebpbtm1Pfj Cebpbtm3Nerl Cebpbtm1Kish Cebpbtm1Vpo

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEBPB
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEBPB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEBPB
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEBPB

    Transcription Factor Targeting: 
    Targeting motifs: HOMER Transcription Factor Regulatory Elements motif viewer 
                                          Consensus sequence:  ATTGCGCAAC 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEBPB:
    hsa-mir-421 (MIRT016122), hsa-mir-423-5p (MIRT038165), hsa-mir-34a-5p (MIRT005723), hsa-mir-155-5p (MIRT001560)

    Block miRNA regulation of human, mouse, rat CEBPB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEBPB (see all 28):
    hsa-miR-21* hsa-miR-376b hsa-miR-3660 hsa-miR-374a hsa-miR-410 hsa-miR-374c hsa-miR-155 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCEBPB 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEBPB
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPB

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEBPB

    Clone
    Products:
         
    OriGene clones in human, mouse for CEBPB (see all 7)
    OriGene ORF clones in mouse, rat for CEBPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEBPB (NM_005194)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPB
    Addgene plasmids for CEBPB 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CEBPB
    Browse ESI BIO Cell Lines and PureStem Progenitors for CEBPB 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPB


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CEBPB_HUMAN, P17676: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular2
    endoplasmic reticulum1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IEA--

    Find genes that share ontologies with CEBPB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CEBPB About   (see all 42)  
    See pathways by source

    SuperPathContained pathways About
    1G protein signaling Ras family GTPases in kinase cascades scheme
    G protein signaling Ras family GTPases in kinase cascades scheme 0.44
    Oncostatin M Signaling Pathway0.37
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    2IL-17 Family Signaling Pathways
    IL-17 Family Signaling Pathways0.51
    IL17 signaling pathway0.51
    3Immune response IFN gamma signaling pathway
    IFN-gamma pathway0.43
    Immune response IFN gamma signaling pathway0.43
    4Cellular Senescence
    Cellular Senescence0.81
    Senescence-Associated Secretory Phenotype (SASP)0.57
    Cellular responses to stress0.81
    5Human Embryonic Stem Cell Pluripotency
    Factors Promoting Cardiogenesis in Vertebrates0.50
    Human Embryonic Stem Cell Pluripotency0.50


    Find genes that share SuperPaths with CEBPB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for CEBPB
        IL-17 Family Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CEBPB (see all 10)
        MAPK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Glucocorticoid Receptor Signaling
    JNK Pathway
    Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for CEBPB
        Lymphocyte Signaling
    Glucose / Energy Metabolism

    Selected GeneGo (Thomson Reuters) Pathways for CEBPB (see all 10)
        Immune response IL-6 signaling pathway
    Immune response MIF in innate immunity response
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development A2B receptor- action via G-protein alpha s
    Development Prolactin receptor signaling

    Selected BioSystems Pathways for CEBPB (see all 19)
        Keap1-Nrf2 Pathway
    Diurnally regulated genes with circadian orthologs
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Adipogenesis

    2 Reactome Pathways for CEBPB
        Transcriptional regulation of white adipocyte differentiation
    Senescence-Associated Secretory Phenotype (SASP)


    3 Kegg Pathways  (Kegg details for CEBPB):
        TNF signaling pathway
    Tuberculosis
    Transcriptional misregulation in cancer

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPB (see all 18): 
              Insulin Signaling Pathway in human mouse rat
              HIV Host Response in human mouse rat
              Adipogenesis in human mouse rat
              Th17 Response in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CEBPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CEBPB (P176761, 2, 3 ENSP000003054224) via UniProtKB, MINT, STRING, and/or I2D (see all 220)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    E2P031221, 2EBI-969696,EBI-7010629 MINT-73556 MINT-73562 MINT-73560 MINT-73571 EBI-969696,EBI-7136851 MINT-73558 MINT-73570 MINT-73550 MINT-73563 EBI-969696,EBI-7028618 MINT-73554 MINT-73552 MINT-73564 EBI-969696,EBI-1779322 MINT-73546 MINT-73557
    CARM1Q86X551, 2, 3, ENSP000003256904EBI-969696,EBI-2339854 MINT-7895017 MINT-7894987 I2D: score=2 STRING: ENSP00000325690
    HMGA1P170962, 3, ENSP000003082274MINT-49733 MINT-49732 MINT-49731 I2D: score=6 STRING: ENSP00000308227
    SMAD3P840222, 3, ENSP000003329734MINT-14023 I2D: score=4 STRING: ENSP00000332973
    TP53P046371, 3, ENSP000002693054EBI-969696,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 23):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001892embryonic placenta development IEA--
    GO:0006355regulation of transcription, DNA-templated IDA--
    GO:0006366transcription from RNA polymerase II promoter TAS10821850
    GO:0006953acute-phase response TAS2112087
    GO:0006954inflammatory response TAS2112087

    Find genes that share ontologies with CEBPB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEBPB

    Selected Novoseek inferred chemical compound relationships for CEBPB gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 54.5 8 1427600 (2), 10079054 (1), 7961962 (1), 10936515 (1) (see all 6)
    amino acid 50.1 3 16026328 (1), 18052938 (1)
    leucine 42 15 12618752 (2), 1741402 (2), 8384717 (1), 9843415 (1) (see all 10)
    retinoic acid 39.5 25 7780146 (4), 8455626 (3), 7535055 (3), 7511442 (2) (see all 8)
    gp 130 35.6 3 7696968 (1), 15771564 (1), 11848612 (1)
    rantes 35.3 7 11022000 (4), 16239564 (1), 15192048 (1)
    cyclic amp 30.6 4 12471036 (1), 11095928 (1), 19423709 (1), 16299228 (1)
    gsno 28.2 3 11534855 (2)
    pge2 26.2 4 9465095 (1), 18294142 (1), 11509602 (1), 12748173 (1)
    pd 98,059 24.4 1 12663507 (1)



    Find genes that share compounds with CEBPB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CEBPB gene (3 alternative transcripts): 
    NM_001285878.1  NM_001285879.1  NM_005194.3  

    Unigene Cluster for CEBPB:

    CCAAT/enhancer binding protein (C/EBP), beta
    Hs.517106  [show with all ESTs]
    Unigene Representative Sequence: BQ683521
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303004(uc002xvi.2)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CEBPB using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEBPB (see all 28):
    hsa-miR-21* hsa-miR-376b hsa-miR-3660 hsa-miR-374a hsa-miR-410 hsa-miR-374c hsa-miR-155 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCEBPB 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CEBPB
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPB
    Clone
    Products:
         
    OriGene clones in human, mouse for CEBPB (see all 7)
    OriGene ORF clones in mouse, rat for CEBPB
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEBPB (NM_005194)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPB
    Addgene plasmids for CEBPB 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CEBPB
    OriGene qSTAR qPCR primer pairs in human, mouse for CEBPB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPB
      QuantiTect SYBR Green Assays in human, mouse, rat CEBPB
      QuantiFast Probe-based Assays in human, mouse, rat CEBPB

    Additional mRNA sequence: 

    BC005132.2 D63161.1 

    7 DOTS entries:

    DT.215081  DT.100844980  DT.100672043  DT.95171893  DT.100701269  DT.120804863  DT.120804869 

    Selected AceView cDNA sequences (see all 200):

    BM768056 AI601206 CB528942 BG055653 BM770629 CF132014 CB529836 AA635792 
    BQ217188 BM694490 BQ000770 BQ574959 AW170715 BQ184219 BC021931 BU621673 
    AW328683 AI702318 AA135498 CB529078 AA443900 BQ029411 BM751802 BM893820 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CEBPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAACGCG
    CEBPB Expression
    About this image


    CEBPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 23 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
             soft tissue 2 ; adipocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 6 entries
             Endochondral Osteoblasts Stylopod Periosteum
             Bone Marrow
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             Monocytes Peripheral Blood
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Lateral Ventricle
     
     Breast (Uncategorized)
             breast ; adipocytes   
    CEBPB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEBPB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517106

    UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
    Tissue specificity: Expressed at low levels in the lung, kidney and spleen

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPB (see all 18): 
              Insulin Signaling Pathway in human mouse rat
              HIV Host Response in human mouse rat
              Adipogenesis in human mouse rat
              Th17 Response in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CEBPB
    OriGene qSTAR qPCR primer pairs in human, mouse for CEBPB
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPB
    QuantiTect SYBR Green Assays in human, mouse, rat CEBPB
    QuantiFast Probe-based Assays in human, mouse, rat CEBPB
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for CEBPB gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cebpb1 , 5 CCAAT/enhancer binding protein (C/EBP), beta1, 5 83.9(n)1
    79.39(a)1
      2 (87.58 cM)5
    126081  NM_009883.31  NP_034013.11 
     1676889155 
    chicken
    (Gallus gallus)
    Aves CEBPB1 CCAAT/enhancer binding protein (C/EBP), beta 74.81(n)
    70.36(a)
      396185  NM_205253.2  NP_990584.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEBPB6
    CCAAT/enhancer binding protein (C/EBP), beta
    61(a)
    1 ↔ 1
    4(147746476-147747516)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF546949.12   -- 78.66(n)    CF546949.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF306854.12   -- 80(n)   140814  AF306854.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cebp-26
    Protein CEBP-2 (cebp-2) mRNA, complete cds
    34(a)
    1 → many
    I(6253019-6253583) WBGene00016754


    ENSEMBL Gene Tree for CEBPB (if available)
    TreeFam Gene Tree for CEBPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CEBPB gene
    CEBPA2  CEBPD2  CEBPE2  CEBPG2  
    3 SIMAP similar genes for CEBPB using alignment to 2 protein entries:     CEBPB_HUMAN (see all proteins):
    CEBPD    CEBPG    CEBPE

    Find genes that share paralogs with CEBPB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CEBPB (see all 79)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507957851,2
    --48805123(+) AGGCAC/GCAGGG 1 -- us2k10--------
    rs1873749871,2
    --48805132(+) GGACAC/TAGTAG 1 -- us2k10--------
    rs1917940191,2
    --48805287(+) AGGAGG/TCAGCT 1 -- us2k10--------
    rs1391657831,2
    --48805341(+) GACAGA/TGTTCT 1 -- us2k10--------
    rs60203491,2
    C,H--48805568(+) AGTGTC/GCCATT 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs456271331,2
    C,F--48805769(+) GGGGCG/AGAGGT 1 -- us2k13Minor allele frequency- A:0.09EU NA 659
    rs1840777961,2
    --48805817(+) TGCCCA/GCCTGC 1 -- us2k10--------
    rs1499254231,2
    --48805867(+) GCCCCA/GGGCAG 1 -- us2k10--------
    rs1865944941,2
    C--48805906(+) GCTAGA/GAGTGG 1 -- us2k10--------
    rs60911091,2
    C--48805989(+) TGAGCC/TTACCC 1 -- us2k12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for CEBPB (48807376 - 48809212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CEBPB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912916CNV Loss21882294
    esv34129CNV Loss18971310
    dgv702n67CNV Gain20364138
    nsv828736CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEBPB
    DNA2.0 Custom Variant and Variant Library Synthesis for CEBPB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 189965    OMIM disorders: --

    1 disease for CEBPB:    
    About MalaCards
    acute promyelocytic leukemia


    Find genes that share disorders with CEBPB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CEBPB gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 55.5 8 7700007 (2), 11250916 (1), 8234276 (1), 2171780 (1) (see all 7)
    choriocarcinoma 38.4 1 7818522 (1)
    necrosis 37.8 8 7935377 (2), 14976147 (1), 17920759 (1), 1730090 (1) (see all 7)
    leukemia promyelocytic acute 31.3 3 7535055 (1), 7780146 (1), 7511442 (1)
    inflammation 24.9 3 9843415 (1), 15778453 (1), 17570496 (1)
    tumors 24.1 16 20209087 (3), 7935377 (2), 16227626 (2), 14527689 (1) (see all 10)
    leukemia t-cell 19.3 2 2078411 (1), 9376596 (1)
    retinoblastoma 15.8 1 14729647 (1)
    myeloid leukemia chronic 13.7 1 1702329 (1)
    leukemia 11.6 6 10233380 (1), 9052733 (1), 1702329 (1), 1514136 (1)

    Genetic Association Database (GAD): CEBPB
    Human Genome Epidemiology (HuGE) Navigator: CEBPB (7 documents)

    Export disorders for CEBPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CEBPB gene, integrated from 10 sources (see all 631):
    (articles sorted by number of sources associating them with CEBPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. (PubMed id 7635140)1, 2, 9 Toda K.... Shizuta Y. (Eur. J. Biochem. 1995)
    2. Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. (PubMed id 20829347)1, 2 Park S.H.... Moon Y. (J. Biol. Chem. 2010)
    3. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (PubMed id 20460359)1, 4 Bennett C.E....Carter A.M. (amp 2010)
    4. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (J. Bone Miner. Res. 2009)
    5. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (J. Lipid Res. 2008)
    6. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients. (PubMed id 12496392)1, 4 Wu J....Kimberly R.P. (J. Immunol. 2003)
    9. Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3. (PubMed id 12810706)1, 2 Eaton E.M. and Sealy L. (J. Biol. Chem. 2003)
    10. Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. (PubMed id 11792321)1, 2 Tahirov T.H.... Ogata K. (Cell 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1051 HGNC: 1834 AceView: LOC440766 Ensembl:ENSG00000172216 euGenes: HUgn1051
    ECgene: CEBPB Kegg: 1051 H-InvDB: CEBPB

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CEBPB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEBPB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/cebpb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CEBPB gene:
    Search GeneIP for patents involving CEBPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CEBPB
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CEBPB   OriGene RNAi products in human, mouse, rat for CEBPB  
     OriGene qPCR primer pairs and template standards for CEBPB   OriGene Protein Over-expression Lysate for CEBPB  
     OriGene MassSpec something-or-other for CEBPB   OriGene clones in human, mouse for CEBPB  
     OriGene qSTAR qPCR primer pairs in human, mouse for CEBPB   OriGene Purified Protein for CEBPB  
     OriGene ORF clones in mouse, rat for CEBPB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CEBPB   OriGene Custom Protein Services for CEBPB  

     
     
     Block miRNA regulation of human, mouse, rat CEBPB using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CEBPB
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEBPB Predesigned siRNA for gene silencing in human, mouse, rat CEBPB
     QuantiFast Probe-based Assays in human, mouse, rat CEBPB QuantiTect SYBR Green Assays in human, mouse, rat CEBPB
     PCR Arrays including human, mouse, rat CEBPB Search Chromatin IP Primers for CEBPB
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPB  GeneGlobe Interaction Network for CEBPB
     Regulatory tfbs in CEBPB promoter
     GenScript Custom Purified and Recombinant Proteins Services for CEBPB GenScript cDNA clones with any tag delivered in your preferred vector for CEBPB
     GenScript Custom Assay Services for CEBPB GenScript Custom overexpressing Cell Line Services for CEBPB
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CEBPB
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CEBPB antibodies
     CEBPB proteins
     CEBPB lysates
     Antibodies for CEBPB
     See all of Abcam's Antibodies, Kits and Proteins for CEBPB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CEBPB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPB
     SwitchGear 3'UTR luciferase reporter plasmids for CEBPB
     SwitchGear Promoter luciferase reporter plasmids for CEBPB
     ThermoFisher Antibody for CEBPB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPB
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEBPB
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEBPB
     LSBio Antibodies in human, mouse, rat for CEBPB
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Addgene plasmids for CEBPB
      Search eBioscience for proteins for CEBPB
      Search eBioscience for elisas for CEBPB
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CEBPB gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4