Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEBPB Gene

protein-coding   GIFtS: 63
GCID: GC20P048807

CCAAT/enhancer binding protein (C/EBP), beta


(Previous symbol: TCF5)
 Explore 74 diseases affiliated with
CEBPB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CEBPB    

Aliases
for CEBPB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Beta1 2     NFIL61
TCF51 2 3 5     NF-IL62
LAP1 2 3     CCAAT/Enhancer-Binding Protein Beta2
C/EBP-Beta1     Interleukin 6-Dependent DNA-Binding Protein2
CRP21 2     Liver-Enriched Transcriptional Activator Protein2
IL6DBP1 2     Nuclear Factor Of Interleukin 62
Nuclear Factor NF-IL62 3     C/EBP Beta3
Transcription Factor 52 3     Liver Activator Protein3
TCF-52 3     

External Ids:    HGNC: 18341   Entrez Gene: 10512   Ensembl: ENSG000001722167   OMIM: 1899655   UniProtKB: P176763   

Export aliases for CEBPB gene to outside databases

Previous GC identifers: GC20P048535 GC20P049445 GC20P049492 GC20P048240 GC20P045555


Summaries
for CEBPB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CEBPB:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA
regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta, and CEBP-gamma.
The encoded protein is important in the regulation of genes involved in immune and inflammatory responses and has been
shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory regions of several acute-phase
and cytokine genes. In addition, the encoded protein can bind the promoter and upstream element and stimulate the
expression of the collagen type I gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses.
Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several
acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and
hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT)
differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor
gamma (PPARG)

Gene Wiki entry for CEBPB


Genomic Views
for CEBPB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.1  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEBPB gene promoter:
         GR   CREB   GR-beta   deltaCREB   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CEBPB promoter sequence
   Search SABiosciences Chromatin IP Primers for CEBPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEBPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.1

CEBPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P048807:  view genomic region     (about GC identifiers)

Start:
 48,807,376 bp from pter      End:
 48,809,212 bp from pter
Size:
 1,837 bases      Orientation:
 plus strand

Proteins
for CEBPB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676 (See protein sequence)
Recommended Name: CCAAT/enhancer-binding protein beta  
Size: 345 amino acids; 36106 Da
Subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28
and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5 (By similarity). Interacts with
ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with CIDEA and CIDEC; these
interactions increase transcriptional activation of a subset of CEBPB downstream target genes (By similarity).
Interacts with DDIT3/CHOP
Subcellular location: Nucleus
6/10 PDB 3D structures from and Proteopedia for CEBPB (see all 10):
1GTW (3D)        1GU4 (3D)        1GU5 (3D)        1H88 (3D)        1H89 (3D)        1H8A (3D)    
Secondary accessions: A8K671 Q96IH2 Q9H4Z5

Explore the universe of human proteins at neXtProt for CEBPB: NX_P17676

Post-translational modifications:

  • Sumoylated by polymeric chains of SUMO2 or SUMO31
  • Phosphorylated at Thr-235 by RPS6KA11
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P17676

    • CEBPB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005185.2  
    ENSEMBL proteins: 
     ENSP00000305422  
    Reactome Protein details: P17676
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: CEBPB
    OriGene Protein Over-expression Lysate: CEBPB
    OriGene Custom Protein Services for CEBPB 
    GenScript Custom Purified and Recombinant Proteins Services for CEBPB
    Novus Biologicals CEBPB Proteins
    Novus Biologicals CEBPB Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CEBPB

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IEA--


    CEBPB for ontologies           About GeneDecksing



    CEBPB Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CEBPB
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 2): CEBPB
    OriGene Custom Antibody Services for CEBPB 
    GenScript Custom Superior Antibodies Services for CEBPB
    Novus Biologicals CEBPB Antibodies
    Abcam antibodies for CEBPB 
    Uscn Antibodies for CEBPB
    ThermoFisher Antibody for CEBPB

    Assay Products for CEBPB: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CEBPB
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for CEBPB

    Protein Domains /
    Families
    for CEBPB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CEBPB for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR004827 bZIP
     IPR016468 CCAAT/enhancer-binding

    Graphical View of Domain Structure for InterPro Entry P17676

    ProtoNet protein and cluster: P17676

    UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Belongs to the bZIP family. C/EBP subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    Function
    for CEBPB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
    Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses.
    Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several
    acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and
    hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in brown adipose tissue (BAT)
    differentiation (By similarity). Regulates the transcriptional induction of peroxisome proliferator-activated receptor
    gamma (PPARG)
    Induction: By ER stress

         Genatlas biochemistry entry for CEBPB:
    CCAAT enhancer binding protein beta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the induction
    of CEBPA and PPARG,required for adipocyte differentiation.

    miRNA
    Products:            		miRTarBase miRNAs that target CEBPB:
    hsa-mir-34a (MIRT005723), hsa-mir-155 (MIRT001560)

    OriGene 3'-UTR Clone: CEBPB
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEBPB
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPB (see all 28):
    hsa-miR-21* hsa-miR-376b hsa-miR-3660 hsa-miR-374a hsa-miR-410 hsa-miR-374c hsa-miR-155 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CEBPB 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEBPB (see all 7)
    OriGene shRNA RFP: CEBPB
    OriGene siRNA: CEBPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEBPB

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CEBPB

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CEBPB (NM_005194)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPB 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CEBPB
    Search LifeMap BioReagents cell lines for CEBPB

    In Situ Assay
    Products:       
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CEBPB

    Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding TAS10821850
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10821850
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS--
    GO:0005515protein binding IPI17724128


    CEBPB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CEBPB:
     Increased cell number in G1, a 

    Animal Models:
         Mouse knock-outs for CEBPB: Cebpbtm1Pfj Cebpbtm3Nerl Cebpbtm1Kish Cebpbtm1Vpo
         15/18 MGI mutant phenotypes (inferred from 12 alleles) (MGI details for Cebpb) (see all 18):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    CEBPB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CEBPB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/38 super-pathways (see all 38) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling_Ras family GTPases in kinase cascades (scheme)
    		G-protein signaling Ras family GTPases in kinase cascades (scheme)1.00
    		Immune response Oncostatin M signaling via MAPK in human cells0.39
    		G-protein signaling_Ras family GTPases in kinase cascades (scheme)1.00
    		Oncostatin M Signaling Pathway0.15
    		Immune response_Oncostatin M signaling via MAPK in human cells0.39
    2Development_CNTF receptor signaling
    		Development_Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Immune response_IL-6 signaling pathway0.30
    		Development Growth hormone signaling via PI3K/AKT and MAPK cascades0.34
    		Immune response IL-6 signaling pathway0.30
    3Immune response_IFN gamma signaling pathway
    		Immune response_IFN gamma signaling pathway1.00
    		IFN-gamma pathway0.43
    		Immune response IFN gamma signaling pathway1.00
    4Development_Prolactin receptor signaling
    		Development_Prolactin receptor signaling1.00
    		Development Prolactin receptor signaling1.00
    5Human Embryonic Stem Cell Pluripotency
    		Human Embryonic Stem Cell Pluripotency1.00
    		Factors Promoting Cardiogenesis in Vertebrates0.50

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/11 EMD Millipore Pathways for CEBPB (see all 11)
        Immune response MIF in innate immunity response
    G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Selected targets of C/EBPbeta

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CEBPB (see all 10)
        MAPK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Glucocorticoid Receptor Signaling
    JNK Pathway
    Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for CEBPB
        Lymphocyte Signaling
    Glucose / Energy Metabolism

    5/10 GeneGo (Thomson Reuters) Pathways for CEBPB (see all 10)
        Immune response IL-6 signaling pathway
    Immune response MIF in innate immunity response
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development A2B receptor- action via G-protein alpha s
    Development Prolactin receptor signaling

    5/18 BioSystems Pathways for CEBPB (see all 18) 
        Oncostatin M Signaling Pathway
    SIDS Susceptibility Pathways
    Adipogenesis
    EGFR1 Signaling Pathway
    Diurnally regulated genes with circadian orthologs

    3        Reactome Pathways for CEBPB
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation
    Expression of CEBPB


    1         Kegg Pathway  (Kegg details for CEBPB):
        Tuberculosis


    CEBPB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CEBPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/183 Interacting proteins for CEBPB (P176761, 2, 3 ENSP000003054224) via UniProtKB, MINT, STRING, and/or I2D (see all 183)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMGA1P170962, 3, ENSP000003082274MINT-49733 MINT-49732 MINT-49731 I2D: score=6 STRING: ENSP00000308227
    CARM1Q86X552, 3, ENSP000003256904MINT-7895017 MINT-7894987 I2D: score=2 STRING: ENSP00000325690
    SMAD3P840222, 3, ENSP000003329734MINT-14023 I2D: score=4 STRING: ENSP00000332973
    TP53P046371, 3, ENSP000002693054EBI-969696,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    CALM1P621583I2D: score=1 
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001892embryonic placenta development IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA--
    GO:0006366transcription from RNA polymerase II promoter TAS10821850
    GO:0006917induction of apoptosis IEA--
    GO:0006953acute-phase response TAS2112087


    CEBPB for ontologies           About GeneDecksing



    Drugs & Compounds
    for CEBPB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CEBPB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEBPB
    10/49 Novoseek chemical compound relationships for CEBPB gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 54.5 8 1427600 (2), 10079054 (1), 7961962 (1), 10936515 (1) (see all 6)
    amino acid 50.1 3 16026328 (1), 18052938 (1)
    leucine 42 15 12618752 (2), 1741402 (2), 8384717 (1), 9843415 (1) (see all 10)
    retinoic acid 39.5 25 7780146 (4), 8455626 (3), 7535055 (3), 7511442 (2) (see all 8)
    gp 130 35.6 3 7696968 (1), 15771564 (1), 11848612 (1)
    rantes 35.3 7 11022000 (4), 16239564 (1), 15192048 (1)
    cyclic amp 30.6 4 12471036 (1), 11095928 (1), 19423709 (1), 16299228 (1)
    gsno 28.2 3 11534855 (2)
    pge2 26.2 4 9465095 (1), 18294142 (1), 11509602 (1), 12748173 (1)
    pd 98,059 24.4 1 12663507 (1)

    Search CenterWatch for drugs/clinical trials and news about CEBPB 

    Transcripts
    for CEBPB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CEBPB gene: 
    NM_005194.3  

    Unigene Clusters for CEBPB:

    CCAAT/enhancer binding protein (C/EBP), beta
    Hs.517106  [show with all ESTs], Hs.719041  [show with all ESTs]
    Unigene Representative Sequences: BQ683521, NM_005194
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303004(uc002xvi.2)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: CEBPB
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEBPB
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPB (see all 28):
    hsa-miR-21* hsa-miR-376b hsa-miR-3660 hsa-miR-374a hsa-miR-410 hsa-miR-374c hsa-miR-155 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmid: CEBPB 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEBPB (see all 7)
    OriGene shRNA RFP: CEBPB
    OriGene siRNA: CEBPB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEBPB
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPB (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPB
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CEBPB (NM_005194)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPB
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPB 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEBPB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEBPB
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEBPB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPB

    Additional cDNA sequence: 

    AF289608.1 AK291536.1 BC007538.1 BC021931.1 

    10 DOTS entries:

    DT.215081  DT.95171893  DT.100844980  DT.97848427  DT.100672043  DT.100780010  DT.120804869  DT.95171896 
    DT.100701269  DT.120804863 

    24/200 AceView cDNA sequences (see all 200):

    BQ574959 BM768056 AI601206 CB529836 BQ000770 CB528942 BM770629 AW170715 
    BQ184219 BM694490 AA635792 BQ217188 CF132014 BG055653 BQ940670 AI081524 
    BM967120 AW328683 AW167675 BM787238 BU616512 CA307209 AK129842 AI367654 

    GeneLoc Exon Structure


    Expression
    for CEBPB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEBPB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGAACGCG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CEBPB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    10/27 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 27) 
    Tissue Anatomical Compartment CellCategory (developmental path)
    AdiposeBody Subcutaneous White AdiposeSubcutaneous White AdipocytesAdipose
    AdiposeCervical Brown Adipose DepotCervical Brown Adipocyte CellsAdipose
    AdiposeCervical Brown Adipose DepotCervical Committed Brown PreadipocytesAdipose
    AdiposeCranial Subcutaneous White AdiposePreadipocytesAdipose
    AdiposeCranial Subcutaneous White AdiposeSubcutaneous White AdipocytesAdipose
    AdiposeCranial Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
    AdiposeFacial Subcutaneous White AdiposePreadipocytesAdipose
    AdiposeFacial Subcutaneous White AdiposeSubcutaneous White AdipocytesAdipose
    AdiposeFacial Subcutaneous White AdiposeSubcutaneous White PreadipocytesAdipose
    AdiposeLumbar Brown Adipose DepotLumbar Brown Adipocyte CellsAdipose
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    HyStem+BMP4-induced 7SMOO32 cells (HyStem+BMP4 inductio...)Adipose

    See CEBPB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEBPB

    SOURCE GeneReport for Unigene clusters: Hs.517106 Hs.719041

    UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
    Tissue specificity: Expressed at low levels in the lung, kidney and spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including CEBPB (see all 18): 
              Insulin Signaling Pathway in human mouse rat
              HIV Host Response in human mouse rat
              Adipogenesis in human mouse rat
              Th17 Response in human mouse rat
              TGFB Signaling Targets in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEBPB
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEBPB
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEBPB
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPB
    In Situ
    Assay Products:     
         		Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CEBPB

    Orthologs
    for CEBPB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CEBPB gene from 5/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CEBPB1 CCAAT/enhancer binding protein (C/EBP), beta 74.97(n)
    70.29(a)    		   396185  NM_205253.2  NP_990584.1 
    lizard
    (Anolis carolinensis)    		 Reptilia CEBPB6
    		 --
    		 56(a)
    		 1 ↔ 1
    		 4(147746476-147747516)
    African clawed frog
    (Xenopus laevis)    		 Amphibia CF546949.12   -- 78.66(n)    CF546949.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii AF306854.12   -- 80(n)   140814  AF306854.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta slbo6
    		 slow border cells
    		 13(a)
    		 1 → many
    		 2R(20219045-20221829)


    ENSEMBL Gene Tree for CEBPB (if available)
    TreeFam Gene Tree for CEBPB (if available) 

    Paralogs
    for CEBPB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEBPB gene
    CEBPA2  CEBPD2  CEBPE2  CEBPG2  
    3 SIMAP similar genes for CEBPB using alignment to 2 protein entries:     CEBPB_HUMAN (see all proteins):
    CEBPD    CEBPG    CEBPE

    CEBPB for paralogs           About GeneDecksing



    Genomic Variants
    for CEBPB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/62 NCBI SNPs in CEBPB are shown (see all 62)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 20 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1507957851,2
    		--48805123(+) AGGCAC/GCAGGG 1 -- us2k10--------
    rs1873749871,2
    		--48805132(+) GGACAC/TAGTAG 1 -- us2k10--------
    rs1917940191,2
    		--48805287(+) AGGAGG/TCAGCT 1 -- us2k10--------
    rs1391657831,2
    		--48805341(+) GACAGA/TGTTCT 1 -- us2k10--------
    rs60203491,2
    		C,H--48805568(+) AGTGTC/GCCATT 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs456271331,2
    		C,--48805769(+) GGGGCG/AGAGGT 1 -- us2k13Minor allele frequency- A:0.09EU NA 659
    rs1840777961,2
    		--48805817(+) TGCCCA/GCCTGC 1 -- us2k10--------
    rs1499254231,2
    		--48805867(+) GCCCCA/GGGCAG 1 -- us2k10--------
    rs1865944941,2
    		--48805906(+) GCTAGA/GAGTGG 1 -- us2k10--------
    rs60911091,2
    		C--48805989(+) TGAGCC/TTACCC 1 -- us2k12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for CEBPB (48807376 - 48809212 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CEBPB
         1 CNV: 47899

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEBPB
    DNA2.0 Custom Variant and Variant Library Synthesis for CEBPB

    Disorders / Diseases
    for CEBPB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CEBPB for disorders           About GeneDecksing

    OMIM gene information: 189965    OMIM disorders: --

    20/74 diseases for CEBPB (see all 74):    About MalaCards
    anaplastic large cell lymphoma    pulmonary immaturity    bile duct carcinoma    myxoid liposarcoma
    squamous cell carcinoma    myeloid leukemia    kaposi's sarcoma    oral squamous cell carcinoma
    secondary hyperparathyroidism    thrombocytosis    cervical squamous cell carcinoma    systemic lupus erythematosus
    acute promyelocytic leukemia    giant cell tumor    lupus erythematosus    liposarcoma
    chronic myeloid leukemia    lymphoblastic leukemia    leukemia    burkitt's lymphoma

    10/34 Novoseek disease relationships for CEBPB gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 55.5 8 7700007 (2), 11250916 (1), 8234276 (1), 2171780 (1) (see all 7)
    choriocarcinoma 38.4 1 7818522 (1)
    necrosis 37.8 8 7935377 (2), 14976147 (1), 17920759 (1), 1730090 (1) (see all 7)
    leukemia promyelocytic acute 31.3 3 7535055 (1), 7780146 (1), 7511442 (1)
    inflammation 24.9 3 9843415 (1), 15778453 (1), 17570496 (1)
    tumors 24.1 16 20209087 (3), 7935377 (2), 16227626 (2), 14527689 (1) (see all 10)
    leukemia t-cell 19.3 2 2078411 (1), 9376596 (1)
    retinoblastoma 15.8 1 14729647 (1)
    myeloid leukemia chronic 13.7 1 1702329 (1)
    leukemia 11.6 6 10233380 (1), 9052733 (1), 1702329 (1), 1514136 (1)

    Genetic Association Database (GAD): CEBPB
    Human Genome Epidemiology (HuGE) Navigator: CEBPB (7 documents)

    Export disorders for CEBPB gene to outside databases

    Publications
    for CEBPB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEBPB gene, integrated from 9 sources (see all 592):
    (articles sorted by number of sources associating them with CEBPB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. (PubMed id 7635140)1, 2, 9 Toda K.... Shizuta Y. (1995)
    2. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients. (PubMed id 12496392)1, 4 Wu J....Kimberly R.P. (2003)
    5. Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3. (PubMed id 12810706)1, 2 Eaton E.M. and Sealy L. (2003)
    6. Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. (PubMed id 11792321)1, 2 Tahirov T.H.... Ogata K. (2002)
    7. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)
    8. C/EBPbeta phosphorylation by RSK creates a functional XEXD caspase inhibitory box critical for cell survival. (PubMed id 11684016)1, 2 Buck M.... Chojkier M. (2001)
    9. Structural analyses of DNA recognition by the AML1/Runx-1 Runt domain and its allosteric control by CBFbeta. (PubMed id 11257229)1, 2 Tahirov T.H....Ogata K. (2001)
    10. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). (PubMed id 1535333)1, 3 Szpirer C....Szpirer J. (1992)

    External Searches for CEBPB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CEBPB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1051 HGNC: 1834 AceView: LOC440766 Ensembl:ENSG00000172216 euGenes: HUgn1051
    ECgene: CEBPB Kegg: 1051 H-InvDB: CEBPB

    Other Databases showing CEBPB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CEBPB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEBPB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEBPB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/cebpb/

    Intellectual Property
    for CEBPB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CEBPB gene:
    Search GeneIP for patents involving CEBPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for CEBPB gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     Browse for Gene Knock-down Tools from EMD Millipore
     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CEBPB
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     OriGene Antibodies for CEBPB   OriGene shRNA RFP for CEBPB  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEBPB   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEBPB  
     OriGene Protein Over-expression Lysate for CEBPB   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for CEBPB   OriGene 3'-UTR Clone for CEBPB  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPB   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEBPB  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for CEBPB   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CEBPB   OriGene Custom Protein Services for CEBPB  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEBPB
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEBPB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEBPB
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEBPB
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPB
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEBPB
     GenScript Custom Purified and Recombinant Proteins Services for CEBPB GenScript cDNA clones with any tag delivered in your preferred vector for CEBPB
     GenScript Custom Assay Services for CEBPB GenScript Custom Superior Antibodies Services for CEBPB
     GenScript Custom overexpressing Cell Line Services for CEBPB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CEBPB promoter
     Search Chromatin IP Primers for CEBPB
     RT2 qPCR Primer Assay in human, mouse, rat CEBPB
     GNC Network for CEBPB
     SABiosciences PCR Arrays including human, mouse, rat CEBPB
     Search Tocris compounds for CEBPB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CEBPB antibodies
     CEBPB proteins
     CEBPB lysates
     Antibodies for CEBPB
     See all of Abcam's Antibodies, Kits and Proteins for CEBPB
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     CEBPB Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for CEBPB
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CEBPB
     SwitchGear 3'UTR luciferase reporter plasmids for CEBPB
     SwitchGear Promoter luciferase reporter plasmids for CEBPB
     ThermoFisher Antibody for CEBPB
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPB
           
    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      CEBPB gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4