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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEBPB Gene

protein-coding   GIFtS: 64
GCID: GC20P048807

CCAAT/Enhancer Binding Protein (C/EBP), Beta


(Previous symbol: TCF5)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Beta1 2     TCF-52 3
TCF51 2 3 5     C/EBP-beta2
Interleukin 6-Dependent DNA-Binding Protein1 2     CRP22
Liver-Enriched Transcriptional Activator Protein1 2     IL6DBP2
Nuclear Factor Of Interleukin 61 2     NF-IL62
Nuclear Factor NF-IL62 3     CCAAT/Enhancer-Binding Protein Beta2
Transcription Factor 52 3     C/EBP Beta3
LAP2 3     Liver Activator Protein3

External Ids:    HGNC: 18341   Entrez Gene: 10512   Ensembl: ENSG000001722167   OMIM: 1899655   UniProtKB: P176763   

Export aliases for CEBPB gene to outside databases

Previous GC identifers: GC20P048535 GC20P049445 GC20P049492 GC20P048240 GC20P045555


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEBPB Gene:
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to
certain DNA regulatory regions. It can also form heterodimers with the related proteins CEBP-alpha, CEBP-delta,
and CEBP-gamma. The encoded protein is important in the regulation of genes involved in immune and inflammatory
responses and has been shown to bind to the IL-1 response element in the IL-6 gene, as well as to regulatory
regions of several acute-phase and cytokine genes. In addition, the encoded protein can bind the promoter and
upstream element and stimulate the expression of the collagen type I gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CEBPB Gene: 
CEBPB (CCAAT/enhancer binding protein (C/EBP), beta) is a protein-coding gene. Diseases associated with CEBPB include pulmonary immaturity, and atrophy of prostate, and among its related super-pathways are MAPK Cascade and IFN-gamma pathway. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CEBPA.

UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory
responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory
regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase
reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in
brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome
proliferator-activated receptor gamma (PPARG)

Gene Wiki entry for CEBPB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000020.10  NC_018931.2  NT_011362.10  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEBPB gene promoter:
         GR   CREB   GR-beta   deltaCREB   c-Myb   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEBPB promoter sequence
   Search SABiosciences Chromatin IP Primers for CEBPB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEBPB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.1   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.1

CEBPB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPB gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20P048807:  view genomic region     (about GC identifiers)

Start:
48,807,376 bp from pter      End:
48,809,212 bp from pter
Size:
1,837 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676 (See protein sequence)
Recommended Name: CCAAT/enhancer-binding protein beta  
Size: 345 amino acids; 36106 Da
Subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with
TRIM28 and PTGES2. Interacts with PRDM16. Interacts with CCDC85B. Forms a complex with THOC5 (By similarity).
Interacts with ZNF638; this interaction increases transcriptional activation (By similarity). Interacts with
CIDEA and CIDEC; these interactions increase transcriptional activation of a subset of CEBPB downstream target
genes (By similarity). Interacts with DDIT3/CHOP
Subcellular location: Nucleus
6/10 PDB 3D structures from and Proteopedia for CEBPB (see all 10):
1GTW (3D)        1GU4 (3D)        1GU5 (3D)        1H88 (3D)        1H89 (3D)        1H8A (3D)    
Secondary accessions: A8K671 Q96IH2 Q9H4Z5

Explore the universe of human proteins at neXtProt for CEBPB: NX_P17676

Explore proteomics data for CEBPB at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated by polymeric chains of SUMO2 or SUMO3
  • UniProtKB: Phosphorylated at Thr-235 by RPS6KA1
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P17676

  • CEBPB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEBPB Protein Expression
    REFSEQ proteins: NP_005185.2  
    ENSEMBL proteins: 
     ENSP00000305422  
    Reactome Protein details: P17676
    Human Recombinant Protein Products for CEBPB: 
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    Novus Biologicals CEBPB Proteins
    Novus Biologicals CEBPB Lysates
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000790nuclear chromatin IEA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IEA--
    GO:0016363nuclear matrix IEA--

    CEBPB for ontologies           About GeneDecksing



    CEBPB Antibody Products: 
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    Assay Products for CEBPB: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR016468 CCAAT/enhancer-binding

    Graphical View of Domain Structure for InterPro Entry P17676

    ProtoNet protein and cluster: P17676

    UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
    Domain: the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription
    factors
    Similarity: Belongs to the bZIP family. C/EBP subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CEBPB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEBPB_HUMAN, P17676
    Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory
    responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory
    regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase
    reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Functions in
    brown adipose tissue (BAT) differentiation (By similarity). Regulates the transcriptional induction of peroxisome
    proliferator-activated receptor gamma (PPARG)
    Induction: By ER stress

         Genatlas biochemistry entry for CEBPB:
    CCAAT enhancer binding protein beta (C/EBP),expressed in preadipocytes and inducing,conjointly with CEBPD,the
    induction of CEBPA and PPARG,required for adipocyte differentiation.

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001077RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA--
    GO:0003677DNA binding TAS10821850
    GO:0003700sequence-specific DNA binding transcription factor activity NAS10821850
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS--
    GO:0005515protein binding IPI12692227
         
    CEBPB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CEBPB:
     Increased cell number in G1, a 

         15/18 MGI mutant phenotypes (inferred from 12 alleles(MGI details for Cebpb) (see all 18):
     adipose tissue  cellular  endocrine/exocrine gland  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  integument  liver/biliary system  mortality/aging 
     muscle  no phenotypic analysis  normal  renal/urinary system  reproductive system 

    CEBPB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CEBPB: Cebpbtm1Pfj Cebpbtm3Nerl Cebpbtm1Kish Cebpbtm1Vpo

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEBPB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CEBPB

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEBPB 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEBPB 

    miRNA
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    miRTarBase miRNAs that target CEBPB:
    hsa-mir-34a (MIRT005723), hsa-mir-155 (MIRT001560)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEBPB
    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPB (see all 28):
    hsa-miR-21* hsa-miR-376b hsa-miR-3660 hsa-miR-374a hsa-miR-410 hsa-miR-374c hsa-miR-155 hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidCEBPB 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of CEBPB 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPB


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CEBPB About   (see all 41)                                                                                              See pathways by source

    SuperPathContained pathways About
    1G-protein signaling Ras family GTPases in kinase cascades (scheme)
    G-protein signaling Ras family GTPases in kinase cascades (scheme)0.44
    Oncostatin M Signaling Pathway0.37
    Immune response Oncostatin M signaling via MAPK in human cells0.39
    2Immune response IFN gamma signaling pathway
    Immune response IFN gamma signaling pathway0.43
    IFN-gamma pathway0.43
    3Human Embryonic Stem Cell Pluripotency
    Human Embryonic Stem Cell Pluripotency0.50
    Factors Promoting Cardiogenesis in Vertebrates0.50
    4Rho Family GTPases
    MAPK Signaling0.58
    ILK Signaling0.49
    5ErbB4 Pathway
    Prolactin Signaling0.54
    Growth Hormone Signaling0.49

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/11 EMD Millipore Pathways for CEBPB (see all 11)
        Immune response MIF in innate immunity response
    G-protein signaling Ras family GTPases in kinase cascades (scheme)
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development Growth hormone signaling via PI3K/AKT and MAPK cascades
    Selected targets of C/EBPbeta

    1 R&D Systems Pathway for CEBPB
        IL-17 Signaling

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CEBPB (see all 10)
        MAPK Signaling
    Factors Promoting Cardiogenesis in Vertebrates
    Glucocorticoid Receptor Signaling
    JNK Pathway
    Epithelial Adherens Junctions

    2 Cell Signaling Technology (CST) Pathways for CEBPB
        Lymphocyte Signaling
    Glucose / Energy Metabolism

    5/10 GeneGo (Thomson Reuters) Pathways for CEBPB (see all 10)
        Immune response IL-6 signaling pathway
    Immune response MIF in innate immunity response
    Transcription Ligand-dependent activation of the ESR1/SP pathway
    Development A2B receptor- action via G-protein alpha s
    Development Prolactin receptor signaling

    5/18 BioSystems Pathways for CEBPB (see all 18)
        Keap1-Nrf2 Pathway
    Diurnally regulated genes with circadian orthologs
    Senescence and Autophagy
    EGFR1 Signaling Pathway
    Adipogenesis

    2        Reactome Pathways for CEBPB
        Developmental Biology
    Transcriptional Regulation of White Adipocyte Differentiation


    3         Kegg Pathways  (Kegg details for CEBPB):
        TNF signaling pathway
    Tuberculosis
    Transcriptional misregulation in cancer


    CEBPB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CEBPB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/188 Interacting proteins for CEBPB (P176761, 2, 3 ENSP000003054224) via UniProtKB, MINT, STRING, and/or I2D (see all 188)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HMGA1P170962, 3, ENSP000003082274MINT-49733 MINT-49732 MINT-49731 I2D: score=6 STRING: ENSP00000308227
    CARM1Q86X552, 3, ENSP000003256904MINT-7895017 MINT-7894987 I2D: score=2 STRING: ENSP00000325690
    SMAD3P840222, 3, ENSP000003329734MINT-14023 I2D: score=4 STRING: ENSP00000332973
    TP53P046371, 3, ENSP000002693054EBI-969696,EBI-366083 I2D: score=2 STRING: ENSP00000269305
    ENSG00000227333Q96KQ73, ENSP000003973234I2D: score=1 STRING: ENSP00000397323
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001892embryonic placenta development IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA--
    GO:0006366transcription from RNA polymerase II promoter TAS10821850
    GO:0006953acute-phase response TAS2112087
    GO:0006954inflammatory response TAS2112087

    CEBPB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CEBPB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEBPB

    10/49 Novoseek inferred chemical compound relationships for CEBPB gene (see all 49)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    chloramphenicol 54.5 8 1427600 (2), 10079054 (1), 7961962 (1), 10936515 (1) (see all 6)
    amino acid 50.1 3 16026328 (1), 18052938 (1)
    leucine 42 15 12618752 (2), 1741402 (2), 8384717 (1), 9843415 (1) (see all 10)
    retinoic acid 39.5 25 7780146 (4), 8455626 (3), 7535055 (3), 7511442 (2) (see all 8)
    gp 130 35.6 3 7696968 (1), 15771564 (1), 11848612 (1)
    rantes 35.3 7 11022000 (4), 16239564 (1), 15192048 (1)
    cyclic amp 30.6 4 12471036 (1), 11095928 (1), 19423709 (1), 16299228 (1)
    gsno 28.2 3 11534855 (2)
    pge2 26.2 4 9465095 (1), 18294142 (1), 11509602 (1), 12748173 (1)
    pd 98,059 24.4 1 12663507 (1)

    Search CenterWatch for drugs/clinical trials and news about CEBPB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEBPB gene: 
    NM_005194.3  

    Unigene Clusters for CEBPB:

    CCAAT/enhancer binding protein (C/EBP), beta
    Hs.517106  [show with all ESTs], Hs.719041  [show with all ESTs], Hs.720603  [show with all ESTs]
    Unigene Representative Sequences: BQ683521, NM_005194, BQ936304
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000303004(uc002xvi.2)
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPB (see all 28):
    hsa-miR-21* hsa-miR-376b hsa-miR-3660 hsa-miR-374a hsa-miR-410 hsa-miR-374c hsa-miR-155 hsa-miR-3613-3p
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPB
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEBPB
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPB

    Additional mRNA sequence: M98056.1 

    10 DOTS entries:

    DT.215081  DT.95171893  DT.100844980  DT.97848427  DT.100672043  DT.100780010  DT.120804869  DT.95171896 
    DT.100701269  DT.120804863 

    24/200 AceView cDNA sequences (see all 200):

    BQ217188 CB528942 CB529836 CF132014 BM768056 BQ000770 BQ574959 BM770629 
    BM694490 BQ184219 BG055653 AI601206 AW170715 AA635792 AI761699 BC021931 
    AA588444 BQ923627 AF289608 BQ649171 BQ940670 AI457990 CD365675 BX411481 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEBPB expression in normal human tissues (normalized intensities)      CEBPB embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCTGAACGCG
    CEBPB Expression
    About this image


    CEBPB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/31 selected tissues (see all 31) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 21 entries
             Visceral White Adipocytes Visceral White Adipose
             HyStem+BMP4-induced 7SMOO32 cells
             breast ; adipocytes   
     
     Bone (Muscoskeletal System)    fully expand to see all 8 entries
             Endochondral Osteoblasts Thoracic Rib
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; cells in endometrial stroma   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   

    See CEBPB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEBPB

    SOURCE GeneReport for Unigene clusters: Hs.517106 Hs.719041 Hs.720603

    UniProtKB/Swiss-Prot: CEBPB_HUMAN, P17676
    Tissue specificity: Expressed at low levels in the lung, kidney and spleen

        SABiosciences Expression via Pathway-Focused PCR Arrays including CEBPB (see all 18): 
              Insulin Signaling Pathway in human mouse rat
              HIV Host Response in human mouse rat
              Adipogenesis in human mouse rat
              Th17 Response in human mouse rat
              TGFB Signaling Targets in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CEBPB gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cebpb1 , 5 CCAAT/enhancer binding protein (C/EBP), beta1, 5 86.85(n)1
    85.03(a)1
      2 (87.58 cM)5
    126081  NM_009883.31  NP_034013.11 
     1676889155 
    chicken
    (Gallus gallus)
    Aves CEBPB1 CCAAT/enhancer binding protein (C/EBP), beta 74.97(n)
    70.29(a)
      396185  NM_205253.2  NP_990584.1 
    lizard
    (Anolis carolinensis)
    Reptilia CEBPB6
    Uncharacterized protein
    57(a)
    1 ↔ 1
    4(147746476-147747516)
    African clawed frog
    (Xenopus laevis)
    Amphibia CF546949.12   -- 78.66(n)    CF546949.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF306854.12   -- 80(n)   140814  AF306854.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta slbo6
    slow border cells
    10(a)
    1 → many
    2R(20219045-20221829)
    worm
    (Caenorhabditis elegans)
    Secernentea cebp-26
    Protein CEBP-2
    30(a)
    1 → many
    I(6253019-6253583)


    ENSEMBL Gene Tree for CEBPB (if available)
    TreeFam Gene Tree for CEBPB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEBPB gene
    CEBPA2  CEBPD2  CEBPE2  CEBPG2  
    3 SIMAP similar genes for CEBPB using alignment to 2 protein entries:     CEBPB_HUMAN (see all proteins):
    CEBPD    CEBPG    CEBPE

    CEBPB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/79 SNPs in CEBPB are shown (see all 79)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1507957851,2
    --48805123(+) AGGCAC/GCAGGG 1 -- us2k10--------
    rs1873749871,2
    --48805132(+) GGACAC/TAGTAG 1 -- us2k10--------
    rs1917940191,2
    --48805287(+) AGGAGG/TCAGCT 1 -- us2k10--------
    rs1391657831,2
    --48805341(+) GACAGA/TGTTCT 1 -- us2k10--------
    rs60203491,2
    C,H--48805568(+) AGTGTC/GCCATT 1 -- us2k14Minor allele frequency- G:0.00NS EA 418
    rs456271331,2
    C,F--48805769(+) GGGGCG/AGAGGT 1 -- us2k13Minor allele frequency- A:0.09EU NA 659
    rs1840777961,2
    --48805817(+) TGCCCA/GCCTGC 1 -- us2k10--------
    rs1499254231,2
    --48805867(+) GCCCCA/GGGCAG 1 -- us2k10--------
    rs1865944941,2
    C--48805906(+) GCTAGA/GAGTGG 1 -- us2k10--------
    rs60911091,2
    C--48805989(+) TGAGCC/TTACCC 1 -- us2k12Minor allele frequency- T:0.00NA 4

    HapMap Linkage Disequilibrium report for CEBPB (48807376 - 48809212 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CEBPB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912916CNV Loss21882294
    esv34129CNV Loss18971310
    dgv702n67CNV Gain20364138
    nsv828736CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 189965    OMIM disorders: --

    20/68 diseases for CEBPB (see all 68):    About MalaCards
    pulmonary immaturity    atrophy of prostate    alk-positive anaplastic large cell lymphoma    phyllode tumor
    myxoid liposarcoma    thrombocytosis    acute promyelocytic leukemia    liposarcoma
    bile duct carcinoma    kaposi's sarcoma    cervical squamous cell carcinoma    anaplastic large cell lymphoma
    giant cell tumor    hyperparathyroidism    retinoblastoma    monocytic leukemia
    choriocarcinoma    myeloma    tuberculosis    epididymitis


    CEBPB for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/34 Novoseek inferred disease relationships for CEBPB gene (see all 34)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    response acute phase 55.5 8 7700007 (2), 11250916 (1), 8234276 (1), 2171780 (1) (see all 7)
    choriocarcinoma 38.4 1 7818522 (1)
    necrosis 37.8 8 7935377 (2), 14976147 (1), 17920759 (1), 1730090 (1) (see all 7)
    leukemia promyelocytic acute 31.3 3 7535055 (1), 7780146 (1), 7511442 (1)
    inflammation 24.9 3 9843415 (1), 15778453 (1), 17570496 (1)
    tumors 24.1 16 20209087 (3), 7935377 (2), 16227626 (2), 14527689 (1) (see all 10)
    leukemia t-cell 19.3 2 2078411 (1), 9376596 (1)
    retinoblastoma 15.8 1 14729647 (1)
    myeloid leukemia chronic 13.7 1 1702329 (1)
    leukemia 11.6 6 10233380 (1), 9052733 (1), 1702329 (1), 1514136 (1)

    Genetic Association Database (GAD): CEBPB
    Human Genome Epidemiology (HuGE) Navigator: CEBPB (7 documents)

    Export disorders for CEBPB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEBPB gene, integrated from 9 sources (see all 604):
    (articles sorted by number of sources associating them with CEBPB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a transcriptional regulatory factor for human aromatase cytochrome P450 gene expression as nuclear factor interleukin-6 (NF-IL6), a member of the CCAAT/enhancer-binding protein family. (PubMed id 7635140)1, 2, 9 Toda K.... Shizuta Y. (1995)
    2. CCAAT/enhancer binding protein alpha, beta and delta gene variants: associations with obesity related phenotypes in the Leeds Family Study. (PubMed id 20460359)1, 4 Bennett C.E....Carter A.M. (2010)
    3. High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. (PubMed id 19453261)1, 4 Yerges L.M....Zmuda J.M. (2009)
    4. Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations. (PubMed id 18660489)1, 4 Lu Y....Boer J.M. (2008)
    5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. A novel polymorphic CAAT/enhancer-binding protein beta element in the FasL gene promoter alters Fas ligand expression: a candidate background gene in African American systemic lupus erythematosus patients. (PubMed id 12496392)1, 4 Wu J....Kimberly R.P. (2003)
    8. Modification of CCAAT/enhancer-binding protein-beta by the small ubiquitin-like modifier (SUMO) family members, SUMO-2 and SUMO-3. (PubMed id 12810706)1, 2 Eaton E.M. and Sealy L. (2003)
    9. Mechanism of c-Myb-C/EBP beta cooperation from separated sites on a promoter. (PubMed id 11792321)1, 2 Tahirov T.H.... Ogata K. (2002)
    10. The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)1, 2 Deloukas P....Rogers J. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1051 HGNC: 1834 AceView: LOC440766 Ensembl:ENSG00000172216 euGenes: HUgn1051
    ECgene: CEBPB Kegg: 1051 H-InvDB: CEBPB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEBPB Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEBPB Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/cebpb/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEBPB gene:
    Search GeneIP for patents involving CEBPB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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