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CEBPA Gene

protein-coding   GIFtS: 60
GCID: GC19M033790

CCAAT/Enhancer Binding Protein (C/EBP), Alpha


(Previous symbol: CEBP)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Alpha1 2
CEBP1 2 5
C/EBP-alpha2
CCAAT/Enhancer-Binding Protein Alpha2
C/EBP Alpha3

External Ids:    HGNC: 18331   Entrez Gene: 10502   Ensembl: ENSG000002458487   OMIM: 1168975   UniProtKB: P497153   

Export aliases for CEBPA gene to outside databases

Previous GC identifers: GC19M034408 GC19M034239 GC19M038466 GC19M038482 GC19M030291


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEBPA Gene:
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and
recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also
heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the
expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this
gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start
codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an
out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons.
(provided by RefSeq, Dec 2013)

GeneCards Summary for CEBPA Gene:
CEBPA (CCAAT/enhancer binding protein (C/EBP), alpha) is a protein-coding gene. Diseases associated with CEBPA include familial acute myeloid leukemia with mutated cebpa, and cytogenetically normal acute myeloid leukemia. GO annotations related to this gene include sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CEBPD.

UniProtKB/Swiss-Prot: CEBPA_HUMAN, P49715
Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many
promoters and the enhanced core homology common to many enhancers

Gene Wiki entry for CEBPA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEBPA gene promoter:
         E2F-3a   CREB   deltaCREB   E2F-2   STAT5A   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEBPA promoter sequence
   Search Chromatin IP Primers for CEBPA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEBPA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1   Ensembl cytogenetic band:  19q13.11   HGNC cytogenetic band: 19q13.1

CEBPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPA gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M033790:  view genomic region     (about GC identifiers)

Start:
33,790,840 bp from pter      End:
33,793,470 bp from pter
Size:
2,631 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CEBPA_HUMAN, P49715 (See protein sequence)
Recommended Name: CCAAT/enhancer-binding protein alpha  
Size: 358 amino acids; 37561 Da
Subunit: Interacts with PRDM16 (By similarity). Binds DNA as a dimer and can form stable heterodimers with C/EBP
beta and gamma. Interacts with UBN1. Interacts with HBV protein X. Interacts with ZNF638; this interaction
increases transcriptional activation (By similarity)
Secondary accessions: A7LNP2 P78319 Q05CA4

Explore the universe of human proteins at neXtProt for CEBPA: NX_P49715

Explore proteomics data for CEBPA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys161, Lys313
  • Modification sites at PhosphoSitePlus

  • See CEBPA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001272758.1  NP_001274353.1  NP_001274364.1  NP_004355.2  

    ENSEMBL proteins: 
     ENSP00000427514  
    Reactome Protein details: P49715

    CEBPA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CEBPA
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CEBPA
    GenScript Custom Purified and Recombinant Proteins Services for CEBPA
    Novus Biologicals CEBPA Proteins
    Novus Biologicals CEBPA Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CEBPA
    Browse Proteins at Cloud-Clone Corp.

    CEBPA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CEBPA
    R&D Systems Antibodies for CEBPA (CEBP alpha)
    Cell Signaling Technology (CST) Antibodies for CEBPA  (C/EBP-alpha)
    OriGene Antibodies for CEBPA
    OriGene Custom Antibody Services for CEBPA
    Novus Biologicals CEBPA Antibodies
    Abcam antibodies for CEBPA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for CEBPA
    LSBio Antibodies in human, mouse, rat for CEBPA

    CEBPA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CEBPA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CEBPA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    bZIP: basic leucine zipper proteins

    2 InterPro protein domains:
     IPR004827 bZIP
     IPR016468 CCAAT/enhancer-binding

    Graphical View of Domain Structure for InterPro Entry P49715

    ProtoNet protein and cluster: P49715

    UniProtKB/Swiss-Prot: CEBPA_HUMAN, P49715
    Similarity: Belongs to the bZIP family. C/EBP subfamily
    Similarity: Contains 1 bZIP (basic-leucine zipper) domain


    CEBPA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEBPA_HUMAN, P49715
    Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many
    promoters and the enhanced core homology common to many enhancers

         Genatlas biochemistry entry for CEBPA:
    CCAAT enhancer binding protein alpha (C/EBP),expressed at highest level in placenta,also expressed in
    liver,lung,skeletal muscle,pancreas,colon,small intestine,peripheral lymphocytes,not expressed in
    preadipocytes,induced by CEBPB and CEBPD,coexpressed with and cross-regulated by PPARG,jointly required for full
    adipocyte differentiation,likely involved in adipocyte differentiation putative down regulated c-Myc target gene,

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding TAS8643605
    GO:0003700sequence-specific DNA binding transcription factor activity IDA12695546
    GO:0003705RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity NAS7575576
    GO:0005515protein binding IPI12692227
    GO:0008134transcription factor binding IPI15664994
         
    CEBPA for ontologies           About GeneDecksing


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 22 alleles(MGI details for Cebpa) (see all 20):
     adipose tissue  behavior/neurological  cardiovascular system  cellular  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     integument  liver/biliary system  mortality/aging  muscle  no phenotypic analysis 

    CEBPA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CEBPA: Cebpatm1Btp Cebpatm1Kgx Cebpatm5Nerl Cebpatm1.1Gonz Cebpatm8.1Nerl Cebpatm1Gjd

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEBPA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEBPA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEBPA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEBPA

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEBPA:
    hsa-mir-193a-5p (MIRT038606), hsa-mir-124-3p (MIRT002025), hsa-mir-744-5p (MIRT037622), hsa-mir-1 (MIRT000390), hsa-mir-125b-5p (MIRT045932), hsa-mir-1226-3p (MIRT036497), hsa-mir-138-5p (MIRT005488)

    Block miRNA regulation of human, mouse, rat CEBPA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEBPA (see all 47):
    hsa-miR-642a hsa-miR-300 hsa-miR-330-5p hsa-miR-25 hsa-miR-374a hsa-miR-374c hsa-miR-124 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidCEBPA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEBPA
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEBPA

    Clone
    Products:
         
    OriGene clones in human, mouse for CEBPA (see all 7)
    OriGene ORF clones in mouse, rat for CEBPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEBPA (NM_004364)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CEBPA
    Browse ESI BIO Cell Lines and PureStem Progenitors for CEBPA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEBPA_HUMAN, P49715: Nucleus

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus NAS7575576
    GO:0005667transcription factor complex ----
    GO:0016363nuclear matrix IEA--
    GO:0035189Rb-E2F complex IEA--
    GO:0043234protein complex ----

    CEBPA for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEBPA About   (see all 21)  
    See pathways by source

    SuperPathContained pathways About
    1L1CAM interactions
    Developmental Biology0.63
    2Akt Signaling
    p38 Signaling0.60
    3PEDF Induced Signaling
    Glucocorticoid Receptor Signaling0.43
    4Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    Non-alcoholic fatty liver disease (NAFLD)0.41
    5Endometrial cancer
    Acute myeloid leukemia0.40

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CEBPA
        Epithelial Tight Junctions
    Glucocorticoid Receptor Signaling
    p38 Signaling

    2 Cell Signaling Technology (CST) Pathways for CEBPA
        Lymphocyte Signaling
    Glucose / Energy Metabolism

    1 GeneGo (Thomson Reuters) Pathway for CEBPA
        Development Leptin signaling via PI3K-dependent pathway

    Selected BioSystems Pathways for CEBPA (see all 8)
        EGFR1 Signaling Pathway
    Adipogenesis
    E2F transcription factor network
    Regulation of Androgen receptor activity
    C-MYB transcription factor network

    1 Reactome Pathway for CEBPA
        Transcriptional regulation of white adipocyte differentiation


    4 Kegg Pathways  (Kegg details for CEBPA):
        Non-alcoholic fatty liver disease (NAFLD)
    Pathways in cancer
    Transcriptional misregulation in cancer
    Acute myeloid leukemia


    CEBPA for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPA (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Insulin Resistance in human mouse rat
              Transcription Factors in human mouse rat
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CEBPA

    Selected Interacting proteins for CEBPA (P497151, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CDX1P479021, 2, 3EBI-1172054,EBI-8514176 MINT-6800315 MINT-6800330 MINT-6800304 I2D: score=2 
    RUNX1Q011962, 3MINT-4791133 I2D: score=2 
    PARP1P098741, 3EBI-1172054,EBI-355676 I2D: score=1 
    UBTFP174802, 3MINT-7720853 I2D: score=1 
    NCOA6Q146863I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 38):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000050urea cycle IEA--
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001889liver development IEA--
    GO:0001892embryonic placenta development IEA--
    GO:0006091generation of precursor metabolites and energy TAS8643605

    CEBPA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEBPA

    Selected Novoseek inferred chemical compound relationships for CEBPA gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    sterol 49.9 4 20096664 (1), 11101056 (1), 16857754 (1), 19416713 (1)
    glycerol 3-phosphate 49.8 2 16537646 (1), 17135605 (1)
    leucine 45.5 4 12668682 (1), 18729193 (1), 11369759 (1), 16455820 (1)
    triacylglycerol 36.5 1 18474584 (1)
    fatty acid 31.4 6 14966273 (1), 16945991 (1), 18263877 (1), 14969395 (1) (see all 6)
    lipid 25.7 4 11851871 (1), 16936206 (1), 19948481 (1)
    retinoic acid 16.7 3 17217039 (1), 17975308 (1)
    acyl-coa 14.1 1 14969395 (1)
    glucose 13.6 4 14966273 (1), 16945991 (1), 15277525 (1)
    deferoxamine 12.6 4 15902299 (2), 15935329 (1)



    CEBPA for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CEBPA gene (4 alternative transcripts): 
    NM_001285829.1  NM_001287424.1  NM_001287435.1  NM_004364.4  

    Unigene Cluster for CEBPA:

    CCAAT/enhancer binding protein (C/EBP), alpha
    Hs.76171  [show with all ESTs]
    Unigene Representative Sequence: NM_004364
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000498907(uc002nun.3)
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CEBPA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEBPA (see all 47):
    hsa-miR-642a hsa-miR-300 hsa-miR-330-5p hsa-miR-25 hsa-miR-374a hsa-miR-374c hsa-miR-124 hsa-miR-326
    SwitchGear 3'UTR luciferase reporter plasmidCEBPA 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CEBPA
    Predesigned siRNA for gene silencing in human, mouse, rat CEBPA
    Clone
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    OriGene clones in human, mouse for CEBPA (see all 7)
    OriGene ORF clones in mouse, rat for CEBPA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEBPA (NM_004364)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CEBPA
    OriGene qSTAR qPCR primer pairs in human, mouse for CEBPA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPA
      QuantiTect SYBR Green Assays in human, mouse, rat CEBPA
      QuantiFast Probe-based Assays in human, mouse, rat CEBPA

    Additional mRNA sequence: 

    BC027902.1 BC063874.1 

    9 DOTS entries:

    DT.313790  DT.99927003  DT.100792942  DT.100792946  DT.91745932  DT.100026402  DT.91917294  DT.121462413 
    DT.100792947 

    Selected AceView cDNA sequences (see all 143):

    N45357 AW316813 BG480298 BC027902 BE855613 CB157806 CR590634 BM910562 
    BE856971 AI762185 AW815561 NM_004364 BM560292 BG315345 BG482052 BM857299 
    BE278960 BE281388 AI492278 AW815422 CD245672 BG480275 BP381812 AW815358 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CEBPA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGGGTGAAG
    CEBPA Expression
    About this image


    CEBPA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Adipose (Muscoskeletal System)    fully expand to see all 26 entries
             Visceral White Adipocytes Visceral White Adipose
             Adipocyte-like cells
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Common Myeloid Progenitor Cells Hematopoietic Bone Marrow
     
     Liver (Hepatobiliary System)    fully expand to see all 5 entries
             Hepatoblasts Liver Bud
             Hepatocyte-like cells
     
     Dermis (Integumentary System)    fully expand to see all 2 entries
             Zigzag Dermal Papilla Cells Dermal Papilla
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
    CEBPA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEBPA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76171
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CEBPA (see all 6): 
              Insulin Signaling Pathway in human mouse rat
              Antigen Presenting Cells in human mouse rat
              Insulin Resistance in human mouse rat
              Transcription Factors in human mouse rat
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CEBPA
    OriGene qSTAR qPCR primer pairs in human, mouse for CEBPA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CEBPA
    QuantiTect SYBR Green Assays in human, mouse, rat CEBPA
    QuantiFast Probe-based Assays in human, mouse, rat CEBPA
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CEBPA gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cebpa1 , 5 CCAAT/enhancer binding protein (C/EBP), alpha1, 5 92(n)1
    95.2(a)1
      7 (21.02 cM)5
    126061  NM_007678.31  NP_031704.21 
     351192935 
    chicken
    (Gallus gallus)
    Aves CEBPA1 CCAAT/enhancer binding protein (C/EBP), alpha 75.13(n)
    66.77(a)
      427549  NM_001031459.1  NP_001026630.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    49(a)
    many ↔ many
    AAWZ02038989(1842-2498)
    African clawed frog
    (Xenopus laevis)
    Amphibia cebpa-prov2 CCAAT/enhancer binding protein (C/EBP), alpha 76.44(n)    BC041714.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cebpa2 CCAAT/enhancer binding protein (C/EBP), alpha 79.62(n)   140815  BC063934.1 
    worm
    (Caenorhabditis elegans)
    Secernentea cebp-26
    Protein CEBP-2 (cebp-2) mRNA, complete cds
    26(a)
    1 → many
    I(6253019-6253583) WBGene00016754


    ENSEMBL Gene Tree for CEBPA (if available)
    TreeFam Gene Tree for CEBPA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEBPA gene
    CEBPD2  CEBPB2  CEBPE2  CEBPG2  
    1 SIMAP similar gene for CEBPA using alignment to 1 protein entry:     CEBPA_HUMAN:
    CEBPE

    CEBPA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEBPA (see all 18)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104035611,2
    C,F,A,H--33790502(+) GGCCTG/ACCCCT 1 -- ds500122Minor allele frequency- A:0.49NS EA NA WA CSA 2347
    rs414647461,2
    C,F--33790536(+) CTCCCC/AGGGGC 1 -- ds50012Minor allele frequency- A:0.27WA NA 238
    rs413556491,2
    C,F--33790556(+) GCCTCG/ACCAAG 1 -- ds50011Minor allele frequency- A:0.03NA 120
    rs747089651,2
    F--33790604(+) CCCCAA/GGAGAC 1 -- ds50010--------
    rs414760471,2
    C--33790635(+) ACTCCA/GTTTGG 1 -- ds50013Minor allele frequency- G:0.28CSA WA NA 240
    rs349958971,2
    C,F,H--33790754(-) ATTTTC/TCCTGG 1 -- ds50014Minor allele frequency- T:0.03EA NS NA 342
    rs722918061,2
    C--33790825(+) TTAAA-/AAGACAC 1 -- ds50010--------
    rs351967241,2
    C--33790928(-) AGGACC/GGCTTG 1 -- ut310--------
    rs1165287761,2
    C,F--33791117(+) AAACCA/CAAAGG 1 -- ut311Minor allele frequency- C:0.01WA 118
    rs126911,2
    C,F,O,A,H--33791127(-) GACTCC/TCTTTC 1 -- ut3121Minor allele frequency- T:0.15MN NS EA EU NA CSA WA 3119

    HapMap Linkage Disequilibrium report for CEBPA (33790840 - 33793470 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CEBPA:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3841n71CNV Loss21882294
    dgv3844n71CNV Loss21882294
    nsv833808CNV Loss17160897
    nsv2463CNV Loss18451855
    nsv911593CNV Loss21882294
    dgv1073e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): CEBPA
    Selected Site Specific Mutation Identification with PCR Assays for CEBPA (see all 10):
    Cosmic IdAA Change
    18495p.G36fs*124
    18543p.K304_Q305insL
    18104p.K313del
    18466p.Q312_K313insQ
    18099p.K313_V314insK
    3 Site Specific Cancer Mutation PCR Panels containing CEBPA:
    Hematopoietic Neoplasms
    Cancer Comprehensive Panel 384HT
    Tumor Suppressor Panel 384HT
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CEBPA
    DNA2.0 Custom Variant and Variant Library Synthesis for CEBPA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 116897   
    OMIM disorders: 601626  
    Selected diseases for CEBPA (see all 54):    
    About MalaCards
    familial acute myeloid leukemia with mutated cebpa    cytogenetically normal acute myeloid leukemia    inherited acute myeloid leukemia    acute myeloid leukemia with cebpa somatic mutations
    acute myeloid leukemia with t(8;21)(q22;q22) translocation    mn1    skin squamous cell carcinoma    dedifferentiated liposarcoma
    acute myeloid leukemia    lymphoid leukemia    liposarcoma    inverted papilloma
    myeloid leukemia    acute leukemia    acute promyelocytic leukemia    gestational diabetes
    retinoblastoma    hepatoblastoma    kaposi's sarcoma    wilms tumor


    CEBPA for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for CEBPA gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leukemia 36.6 4 18729193 (1), 15326310 (1), 18239623 (1)
    retinoblastoma 34.2 2 12045192 (1), 9261165 (1)
    acute leukemia 28.4 1 12351377 (1)
    obesity 22.2 1 16311219 (1)
    tumors 4.73 6 16537832 (1), 11522776 (1), 18024476 (1), 11242107 (1) (see all 6)
    necrosis 0 1 11522776 (1)

    Genetic Association Database (GAD): CEBPA
    Human Genome Epidemiology (HuGE) Navigator: CEBPA (43 documents)

    Export disorders for CEBPA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEBPA gene, integrated from 10 sources (see all 435):
    (articles sorted by number of sources associating them with CEBPA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. (PubMed id 18768433)1, 4, 9 Pabst T....Mueller B.U. (J. Clin. Oncol. 2008)
    2. CCAAT/enhancer-binding protein alpha (CEBPA) polymorphisms and mutations in healthy individuals and in patients with peripheral artery disease, ischaemic heart disease and hyperlipidaemia. (PubMed id 20492756)1, 4, 9 Fuchs O....Chochola M. (Folia Biol. (Praha) 2010)
    3. Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. (PubMed id 12692518)1, 4, 9 Barjesteh van Waalwijk van Doorn-Khosrovani S....Delwel R. (Hematol. J. 2003)
    4. Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). (PubMed id 12351377)1, 4, 9 Preudhomme C....Dombret H. (Blood 2002)
    5. CEBPA point mutations in hematological malignancies. (PubMed id 15674366)1, 4, 9 Leroy H....Preudhomme C. (Leukemia 2005)
    6. CEBPA polymorphisms and mutations in patients with acute myeloid leukemia, myelodysplastic syndrome, multiple myeloma and non-Hodgkin's lymphoma. (PubMed id 18182175)1, 4, 9 Fuchs O....Benesova K. (amp 2008)
    7. Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype. (PubMed id 16046528)1, 4, 9 Boissel N....Preudhomme C. (Blood 2005)
    8. Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). (PubMed id 1535333)1, 3, 9 Szpirer C....Szpirer J. (Genomics 1992)
    9. A copy number repeat polymorphism in the transactivation domain of the CEPBA gene is possibly associated with a protective effect against acquired CEBPA mutations: an analysis in 1135 patients with AML and 187 healthy controls. (PubMed id 20888888)1, 4 Schnittger S....Haferlach T. (Exp. Hematol. 2011)
    10. Acute myeloid leukemia with biallelic CEBPA gene mutations and normal karyotype represents a distinct genetic entity associated with a favorable clinical outcome. (PubMed id 20038735)1, 4 Dufour A....Spiekermann K. (J. Clin. Oncol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1050 HGNC: 1833 AceView: CEBPA Ensembl:ENSG00000245848 euGenes: HUgn1050
    ECgene: CEBPA Kegg: 1050 H-InvDB: CEBPA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CEBPA Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEBPA Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/cebpa/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEBPA gene:
    Search GeneIP for patents involving CEBPA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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