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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CEBPA Gene

protein-coding GIFtS: 63
GCID: GC19M033790

CCAAT/enhancer binding protein (C/EBP), alpha

(Previous symbol: CEBP)

Explore 40 diseases affiliated with
CEBPA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CCAAT/Enhancer Binding Protein (C/EBP), Alpha¹ ²
CEBP¹ ² ⁵
C/EBP-Alpha¹
CCAAT/Enhancer-Binding Protein Alpha²
C/EBP Alpha³

External Ids:	HGNC: 1833¹	Entrez Gene: 1050²	Ensembl: ENSG00000245848⁷	OMIM: 116897⁵	UniProtKB: P49715³

Export aliases for CEBPA gene to outside databases

Previous GC identifers: GC19M034408 GC19M034239 GC19M038466 GC19M038482 GC19M030291

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEBPA:

The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain

promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded

protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that

plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby

inhibiting these kinases and causing growth arrest in cultured cells. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CEBPA_HUMAN, P49715

Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many

promoters and the enhanced core homology common to many enhancers

Gene Wiki entry for CEBPA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CEBPA gene promoter:
E2F-3a CREB deltaCREB E2F-2 STAT5A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CEBPA promoter sequence

Search SABiosciences Chromatin IP Primers for CEBPA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEBPA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1 Ensembl cytogenetic band: 19q13.11 HGNC cytogenetic band: 19q13.1

CEBPA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEBPA gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M033790: view genomic region (about GC identifiers)

Start:	33,790,840 bp from pter	End:	33,793,470 bp from pter
Size:	2,631 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CEBPA_HUMAN, P49715 (See protein sequence)

Recommended Name: CCAAT/enhancer-binding protein alpha

Size: 358 amino acids; 37561 Da

Subunit: Interacts with PRDM16 (By similarity). Binds DNA as a dimer and can form stable heterodimers with C/EBP beta

and gamma. Interacts with UBN1. Interacts with HBV protein X. Interacts with ZNF638; this interaction increases

transcriptional activation (By similarity)

Subcellular location: Nucleus

Secondary accessions: A7LNP2 P78319 Q05CA4

Explore the universe of human proteins at neXtProt for CEBPA: NX_P49715

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P49715

CEBPA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004355.2

ENSEMBL proteins:

ENSP00000427514

Reactome Protein details: P49715
Human Recombinant Protein Products:

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	Novus Biologicals CEBPA Proteins Novus Biologicals CEBPA Lysate
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CEBPA
	Browse Proteins at Uscn

Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	NAS	7575576
GO:0005667	transcription factor complex	--	--
GO:0016363	nuclear matrix	IEA	--
GO:0035189	Rb-E2F complex	IEA	--
GO:0043234	protein complex	--	--

CEBPA for ontologies About GeneDecksing

CEBPA Antibody Products:

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	R&D Systems Antibodies for CEBPA (CEBP alpha)
	Cell Signaling Technology (CST) Antibodies for CEBPA (C/EBP-alpha)
	OriGene Antibodies (see all 2): CEBPA OriGene Custom Antibody Services for CEBPA
	GenScript Custom Superior Antibodies Services for CEBPA
	Novus Biologicals CEBPA Antibodies
	Abcam antibodies for CEBPA
	Browse Antibodies at Uscn
	ThermoFisher Antibody for CEBPA

Assay Products for CEBPA:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CEBPA
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CEBPA for domains About GeneDecksing

2 InterPro domains/families:

IPR004827 bZIP

IPR016468 CCAAT/enhancer-binding

Graphical View of Domain Structure for InterPro Entry P49715

ProtoNet protein and cluster: P49715

UniProtKB/Swiss-Prot: CEBPA_HUMAN, P49715

Similarity: Belongs to the bZIP family. C/EBP subfamily

Similarity: Contains 1 bZIP (basic-leucine zipper) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CEBPA_HUMAN, P49715

Function: C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many

promoters and the enhanced core homology common to many enhancers

Genatlas biochemistry entry for CEBPA:

CCAAT enhancer binding protein alpha (C/EBP),expressed at highest level in placenta,also expressed in

liver,lung,skeletal muscle,pancreas,colon,small intestine,peripheral lymphocytes,not expressed in

preadipocytes,induced by CEBPB and CEBPD,coexpressed with and cross-regulated by PPARG,jointly required for full

adipocyte differentiation,likely involved in adipocyte differentiation putative down regulated c-Myc target gene,

miRNA Products:		miRTarBase miRNAs that target CEBPA: hsa-mir-124 (MIRT002025), hsa-mir-1 (MIRT000390), hsa-mir-138 (MIRT005488)

		OriGene 3'-UTR Clone: CEBPA Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEBPA
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPA (see all 47):
		hsa-miR-642a hsa-miR-300 hsa-miR-330-5p hsa-miR-25 hsa-miR-374a hsa-miR-374c hsa-miR-124 hsa-miR-326

		SwitchGear 3'UTR luciferase reporter plasmid: CEBPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEBPA (see all 7) OriGene shRNA RFP: CEBPA OriGene siRNA: CEBPA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEBPA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CEBPA

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CEBPA (NM_004364)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEBPA
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEBPA

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CEBPA
		Search LifeMap BioReagents cell lines for CEBPA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPA

Gene Ontology (GO): 5/12 molecular function terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	TAS	8643605
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA	12695546
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity	NAS	7575576
GO:0005515	protein binding	IPI	16490787
GO:0008134	transcription factor binding	IPI	15664994

CEBPA for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for CEBPA: Cebpa^tm1Btp Cebpa^tm1Kgx Cebpa^tm5Nerl Cebpa^tm1.1Gonz Cebpa^tm8.1Nerl Cebpa^tm1Gjd
     15/20 MGI mutant phenotypes (inferred from 22 alleles) (MGI details for Cebpa) (see all 20):

adipose tissue	behavior/neurological	cardiovascular system	cellular	digestive/alimentary
endocrine/exocrine gland	growth/size	hematopoietic system	homeostasis/metabolism	immune system
integument	liver/biliary system	mortality/aging	muscle	no phenotypic analysis

CEBPA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Development_Leptin signaling via PI3K-dependent pathway

Development Leptin signaling via PI3K-dependent pathway

1.00

Development_Leptin signaling via PI3K-dependent pathway

1.00

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Glucose / Energy Metabolism

Glucose / Energy Metabolism

1.00

Expression of CEBPA

Expression of CEBPA

1.00

Transcriptional Regulation of White Adipocyte Differentiation

Transcriptional Regulation of White Adipocyte Differentiation

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CEBPA

	Selected targets of C/EBPalpha
	Development Leptin signaling via PI3K-dependent pathway

3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CEBPA

	Epithelial Tight Junctions
	Glucocorticoid Receptor Signaling
	p38 Signaling

2 Cell Signaling Technology (CST) Pathways for CEBPA

	Lymphocyte Signaling
	Glucose / Energy Metabolism

1 GeneGo (Thomson Reuters) Pathway for CEBPA

Development Leptin signaling via PI3K-dependent pathway

5/8 BioSystems Pathways for CEBPA (see all 8)

	Adipogenesis
	EGFR1 Signaling Pathway
	C-MYB transcription factor network
	FOXA2 and FOXA3 transcription factor networks
	Validated targets of C-MYC transcriptional repression

3 Reactome Pathways for CEBPA

	Expression of CEBPA
	Developmental Biology
	Transcriptional Regulation of White Adipocyte Differentiation

2 Kegg Pathways (Kegg details for CEBPA):

	Pathways in cancer
	Acute myeloid leukemia

CEBPA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CEBPA

5/80 Interacting proteins for CEBPA (P49715^{1, 2, 3}) via UniProtKB, MINT, STRING, and/or I2D (see all 80)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDX1	P47902²^,³	MINT-6800315 MINT-6800330 MINT-6800304 I2D: score=2
RUNX1	Q01196²^,³	MINT-4791133 I2D: score=2
PARP1	P09874¹^,³	EBI-1172054,EBI-355676 I2D: score=1
UBTF	P17480²^,³	MINT-7720853 I2D: score=1
NCOA6	Q14686³	I2D: score=5

About this table

Gene Ontology (GO): 5/38 biological process terms (GO ID links to tree view) (see all 38): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000050	urea cycle	IEA	--
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	IEA	--
GO:0001889	liver development	IEA	--
GO:0001892	embryonic placenta development	IEA	--
GO:0006091	generation of precursor metabolites and energy	TAS	8643605

CEBPA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CEBPA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEBPA
10/13 Novoseek chemical compound relationships for CEBPA gene (see all 13) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sterol	49.9	4	20096664 (1), 11101056 (1), 16857754 (1), 19416713 (1)
glycerol 3-phosphate	49.8	2	16537646 (1), 17135605 (1)
leucine	45.5	4	12668682 (1), 18729193 (1), 11369759 (1), 16455820 (1)
triacylglycerol	36.5	1	18474584 (1)
fatty acid	31.4	6	14966273 (1), 16945991 (1), 18263877 (1), 14969395 (1) (see all 6)
lipid	25.7	4	11851871 (1), 16936206 (1), 19948481 (1)
retinoic acid	16.7	3	17217039 (1), 17975308 (1)
acyl-coa	14.1	1	14969395 (1)
glucose	13.6	4	14966273 (1), 16945991 (1), 15277525 (1)
deferoxamine	12.6	4	15902299 (2), 15935329 (1)

Search CenterWatch for drugs/clinical trials and news about CEBPA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CEBPA gene:

NM_004364.3

Unigene Cluster for CEBPA:

CCAAT/enhancer binding protein (C/EBP), alpha

Hs.740432 [show with all ESTs]

Unigene Representative Sequence: NM_004364

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000498907(uc002nun.3)

miRNA Products:		OriGene 3'-UTR Clone: CEBPA Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEBPA
		8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate CEBPA (see all 47):
		hsa-miR-642a hsa-miR-300 hsa-miR-330-5p hsa-miR-25 hsa-miR-374a hsa-miR-374c hsa-miR-124 hsa-miR-326

		SwitchGear 3'UTR luciferase reporter plasmid: CEBPA 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEBPA (see all 7) OriGene shRNA RFP: CEBPA OriGene siRNA: CEBPA
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		GenScript: all cDNA clones in your preferred vector: CEBPA (NM_004364)
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		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CEBPA
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEBPA
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPA

Additional cDNA sequence:

BC027902.1 BC063874.1

7 DOTS entries:

DT.313790 DT.99927003 DT.100792942 DT.91745932 DT.100792946 DT.100026402 DT.91917294

24/143 AceView cDNA sequences (see all 143):

BE855613 BG480298 AI762185 N45357 BG482052 BM910562 AW316813 CB157806

AW815561 NM_004364 CR590634 BM560292 BE856971 BG315345 BC027902 BG480275

Y11525 AA340727 T52113 AW815422 CD618576 BX343831 AA367768 BM852648

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEBPA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGGGTGAAG

About this image

CEBPA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/29 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 29)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Adipocytes

Selective marker (cell-identifying gene)

Adipose

Body Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Cervical Brown Adipose Depot

Cervical Brown Adipocyte Cells

Adipose

Cervical Brown Adipose Depot

Cervical Committed Brown Preadipocytes

Adipose

Cranial Subcutaneous White Adipose

Preadipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Cranial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Preadipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Adipocytes

Adipose

Facial Subcutaneous White Adipose

Subcutaneous White Preadipocytes

Adipose

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Immature adipocyte-like cells (Differentiation of ...)

Adipose

Hepatocyte-like cells (Functional hepatocyt...)

Syncytiotrophoblast-like cells (Generation of syncyt...)

Posterior foregut-like cells (A scalable, suspensi...)

See CEBPA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEBPA

SOURCE GeneReport for Unigene cluster: Hs.740432

SABiosciences Expression via Pathway-Focused PCR Arrays including CEBPA (see all 6):

Insulin Signaling Pathway in human mouse rat

Antigen Presenting Cells in human mouse rat

Insulin Resistance in human mouse rat

Transcription Factors in human mouse rat

Diabetes in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEBPA

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEBPA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CEBPA gene from 4/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CEBPA¹	CCAAT/enhancer binding protein (C/EBP), alpha	79(n) 71.16(a)		427549 NM_001031459.1 NP_001026630.1
African clawed frog (Xenopus laevis)	Amphibia	cebpa-prov²	CCAAT/enhancer binding protein (C/EBP), alpha	76.44(n)		BC041714.1
zebrafish (Danio rerio)	Actinopterygii	cebpa²	CCAAT/enhancer binding protein (C/EBP), alpha	79.62(n)		140815 BC063934.1
fruit fly (Drosophila melanogaster)	Insecta	slbo⁶	slow border cells	14(a)	1 → many	2R(20219045-20221829)

ENSEMBL Gene Tree for CEBPA (if available)
TreeFam Gene Tree for CEBPA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CEBPA gene

CEBPD² CEBPB² CEBPE² CEBPG²

1 SIMAP similar gene for CEBPA using alignment to 1 protein entry: CEBPA_HUMAN:

CEBPE

CEBPA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs1049967^1,2	C	non-pathogenic	33792567(-)	`GCAGCG/TCGCTC`	3	A S	mis¹ us2k¹		1		NA	2
rs3745972^1,2	C	non-pathogenic	33792608(-)	`CCCCGA/CGCCCG`	3	E A	mis¹ us2k¹		0	--	--	--	--
rs34529039^1,2	C,F,	non-pathogenic	33792631(-)	`CCCACG/TCCCGT`	3	T	us2k¹ syn¹		2		EU NA	520
rs28931590^1,2	C	other	33793070(-)	`CCAGCA/TCAGCC`	3	H L	mis¹ us2k¹		0	--	--	--	--
rs10403561^1,2	C,F,A,H,	--	33790502(+)	`GGCCTG/ACCCCT`	1	--	ds500¹		22		NS EA NA WA CSA	2347
rs41464746^1,2	C,F,	--	33790536(+)	`CTCCCC/AGGGGC`	1	--	ds500¹		2		WA NA	238
rs41355649^1,2	C,F,	--	33790556(+)	`GCCTCG/ACCAAG`	1	--	ds500¹		1		NA	120
rs74708965^1,2		--	33790604(+)	`CCCCAA/GGAGAC`	1	--	ds500¹		0	--	--	--	--
rs41476047^1,2	C,	--	33790635(+)	`NNNNCA/GTTTGG`	1	--	ds500¹		3		CSA WA NA	240
rs34995897^1,2	C,F,H,	--	33790754(-)	`ATTTTC/TCCTGG`	1	--	ds500¹		4		EA NS NA	342

HapMap Linkage Disequilibrium report for CEBPA (33790840 - 33793470 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CEBPA
1 CNV: 4076
Human Gene Mutation Database (HGMD): CEBPA

5/10 SABiosciences Cancer Mutation PCR Assays for CEBPA (see all 10):

Cosmic Id	AA Change
18495	p.G36fs*124
18543	p.K304_Q305insL
18104	p.K313del
18466	p.Q312_K313insQ
18099	p.K313_V314insK

3 SABiosciences Cancer Mutation PCR Arrays containing CEBPA:

Hematopoietic Neoplasms

Cancer Comprehensive Panel 384HT

Tumor Suppressor Panel 384HT

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CEBPA for disorders           About GeneDecksing

OMIM gene information: 116897
OMIM disorders: 601626
20/40 diseases for CEBPA (see all 40):    About MalaCards

non-hodgkin lymphoma skin squamous cell carcinoma acute promyelocytic leukemia squamous cell carcinoma

hodgkin's lymphoma brain injury acute lymphoblastic leukemia gestational diabetes

acute myeloid leukemia lymphoblastic leukemia myeloid leukemia insulin resistance

kaposi's sarcoma leukemia acute leukemia wilms tumor

multiple myeloma myelodysplastic syndrome retinoblastoma hepatitis b

6 Novoseek disease relationships for CEBPA gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
leukemia	36.6	4	18729193 (1), 15326310 (1), 18239623 (1)
retinoblastoma	34.2	2	12045192 (1), 9261165 (1)
acute leukemia	28.4	1	12351377 (1)
obesity	22.2	1	16311219 (1)
tumors	4.73	6	16537832 (1), 11522776 (1), 18024476 (1), 11242107 (1) (see all 6)
necrosis	0	1	11522776 (1)

Genetic Association Database (GAD): CEBPA
Human Genome Epidemiology (HuGE) Navigator: CEBPA (43 documents)

Export disorders for CEBPA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CEBPA gene, integrated from 9 sources (see all 387):
(articles sorted by number of sources associating them with CEBPA)

Utopia: connect your pdf to the dynamic
world of online information

Biallelic mutations in the CEBPA gene and low CEBPA expression levels as prognostic markers in intermediate-risk AML. (PubMed id 12692518)^{1, 4, 9} Barjesteh van Waalwijk van Doorn-Khosrovani S....Delwel R. (2003)
Favorable prognostic significance of CEBPA mutations in patients with de novo acute myeloid leukemia: a study from the Acute Leukemia French Association (ALFA). (PubMed id 12351377)^{1, 4, 9} Preudhomme C....Dombret H. (2002)
CEBPA point mutations in hematological malignancies. (PubMed id 15674366)^{1, 4, 9} Leroy H....Preudhomme C. (2005)
Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype. (PubMed id 16046528)^{1, 4, 9} Boissel N....Preudhomme C. (2005)
Chromosomal localization in man and rat of the genes encoding the liver-enriched transcription factors C/EBP, DBP, and HNF1/LFB-1 (CEBP, DBP, and transcription factor 1, TCF1, respectively) and of the hepatocyte growth factor/scatter factor gene (HGF). (PubMed id 1535333)^{1, 3, 9} Szpirer C....Szpirer J. (1992)
Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype. (PubMed id 16076867)^{1, 4} Schnittger S....Falini B. (2005)
Ubinuclein, a novel nuclear protein interacting with cellular and viral transcription factors. (PubMed id 10725330)^{1, 2} Aho S.... Uitto J. (2000)
Molecular cloning, sequence, and expression patterns of the human gene encoding CCAAT/enhancer binding protein alpha (C/EBP alpha). (PubMed id 7575576)^{1, 2} Antonson P. and Xanthopoulos K.G. (1995)
Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. (PubMed id 1840554)^{1, 3} Cao Z....McKnight S.L. (1991)
Somatic CEBPA mutations are a frequent second event in families with germline CEBPA mutations and familial acute myeloid leukemia. (PubMed id 18768433)^{1, 9} Pabst T....Mueller B.U. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1050	HGNC: 1833	AceView: CEBPA	Ensembl:ENSG00000245848	euGenes: HUgn1050
ECgene: CEBPA	Kegg: 1050	H-InvDB: CEBPA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CEBPA	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CEBPA	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/cebpa/

Intellectual Property for CEBPA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CEBPA gene:
Search GeneIP for patents involving CEBPA

GeneCards and IP:
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