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CEACAM8 Gene

protein-coding GIFtS: 53

GC19M047776

carcinoembryonic antigen-related cell adhesion molecule 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CGM6)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CD66b ^¹, ²
CD67 ^²
CGM6 ^², ³
NCA-95 ^²

Descriptions
CD66b antigen ^³
CD67 antigen ^³
Carcinoembryonic antigen CGM6 ^³
Non-specific cross-reacting antigen NCA-95 ^³
carcinoembryonic antigen gene family member 6 ^²
carcinoembryonic antigen-related cell adhesion molecule 8 ^²

External Ids
HGNC: 1820¹
Entrez Gene: 1088²
UniProtKB: P31997³
Ensembl: ENSG00000124469⁷

Search outside databases for aliases for CEACAM8 gene

Previous GC identifers: GC19M043731 GC19M043476 GC19M047760

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for CEACAM8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CEACAM8 gene

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CEACAM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M047776: (about GC identifiers)

Start:	47,776,235 bp from pter
End:	47,790,906 bp from pter
Size:	14,672 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CEAM8_HUMAN, P31997 (See protein sequence)

Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 8 precursor

Size: 349 amino acids; 38154 Da

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor

PDB structures from and Proteopedia :

2DKS (3D)

Secondary accessions: O60399 Q16574

REFSEQ proteins: NP_001807.2

ENSEMBL proteins:

ENSP00000244336

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CD66b)
	Human Recombinant Proteins from Abnova (CEACAM8)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	2306228
GO:0005886	plasma membrane	TAS	2306228
GO:0005887	integral to plasma membrane	TAS	2208113
GO:0031225	anchored to membrane	IEA	--

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Antibodies for CEACAM8:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	R&D Systems Antibodies for CEACAM8 (CEACAM-8/CD66b)
	Antibodies from Abcam (CD66b), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Novus Biologicals Antibodies for CEACAM8

Assays for CEACAM8:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry P31997

ProtoNet protein and cluster: P31997

2 Blocks protein families:

IPB003599 Immunoglobulin subtype

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CEAM8_HUMAN, P31997

Similarity: Belongs to the immunoglobulin superfamily. CEA family

Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CEACAM8)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001816

Applied Biosystems Silencer® siRNAs for CEACAM8

Sigma-Aldrich siRNA and siRNA Panels for CEACAM8

Sigma-Aldrich shRNA for CEACAM8

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001816
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001816
untagged cDNA clones in CMV expression vector (see all 2): NM_001816

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001816

Genatlas biochemistry entry for CEACAM8:

carcinoembryonic antigen-related cell adhesion molecule 8 (see CEA@,PSG@)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for CEACAM8

5/17 Interacting proteins for CEACAM8 (ENSP00000244336³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEACAM1	ENSP00000367304³	STRING (score=.962)
CEACAM6	ENSP00000199764³	STRING (score=.962)
APOH	ENSP00000205948³	STRING (score=.939)
ADCYAP1	ENSP00000269200³	STRING (score=.852)
CD69	ENSP00000228434³	STRING (score=.777)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	2208113

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CEACAM8
1 Novoseek chemical compound relationship for CEACAM8 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
fmlp	39.57	4	8977287 (2)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CEACAM8)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001816

Sigma-Aldrich siRNA and siRNA Panels for CEACAM8

Sigma-Aldrich shRNA for CEACAM8

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001816

REFSEQ mRNAs for CEACAM8 gene:

NM_001816.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001816

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001816
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001816
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_001816

Additional cDNA sequence:

AK297012.1 AK312652.1 BC026263.1 D90064.1 M33326.1 X52378.1

5 DOTS entries:

DT.307942 DT.100822610 DT.121424607 DT.92414191 DT.95146984

22 AceView cDNA sequences:

BC026263 NM_001816 X52378 D90064 BF892544 M33326 BF923154 BF925291

BI023346 BF891891 BF925283 BF925284 BF894287 BF898032 BQ336330 BF925290

BF898025 BF904943 BQ336337 BI019240 AW844115 BF336867

highest scoring ESTs for CEACAM8:

M33326 BC026263 BF892544 D90064 X52378 BF891891 BF905790 BF923154 BF925283 BF925284

Unigene Cluster for CEACAM8:

Carcinoembryonic antigen-related cell adhesion molecule 8

Hs.41 [show with all ESTs]

Unigene Representative Sequence: NM_001816

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000244336

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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CEACAM8 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CEACAM8

¹ / ² / ³

3 probe-sets matching CEACAM8 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33530_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	M33326	1.00	1.00	1.00	1
206676_at²^{, 3}	U133-A	1	1.00	1.00	--	--	M33326	1.00	1.00	1.00	1
206676_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CEACAM8 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.41
Expression variation in blood from EXPOLDB for CEACAM8
UniProtKB/Swiss-Prot: CEAM8_HUMAN, P31997
Tissue specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for CEACAM8 gene from 2 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	CEACAM8¹	--	carcinoembryonic antigen-related cell adhesion molecule more	99.43(n) 99.71(a)	456079 XM_512705.2 XP_512705.2
cow (Bos taurus)	CEACAM6¹	--	similar to carcinoembryonic antigen-related cell adhesion more	70.37(n) 54.32(a)	507167 XM_583733.3 XP_583733.2

About this table Species with no ortholog for CEACAM8

ENSEMBL Gene Tree for CEACAM8

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for CEACAM8 gene

PSG5² PSG9² PSG8² PSG6² CEACAM5² PSG11² CEACAM1² CEACAM7²

PSG3² CEACAM6² PSG2² PSG7² PSG1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/109 NCBI SNPs in CEACAM8 are shown (see all 109 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs8103051^1,2	A,C,F,H	47779268(+)	`ACTCCA/CATCAT`	1	I/M	mis¹ ese³		14	EU EA WA NS	1338
	rs2267631^1,2	A,C,F,H	47792469(+)	`GAGGGG/AGCGGC`	1	--	ng3¹		14	EA EU WA NA NS	2554
	rs45476198^1,2	C,F	47779324(-)	`ATGCTT/GTAGTA`	1	V/L	mis¹		2	NS	82
--	rs28447294^1,2	C,F	47791198(+)	`GGAGAC/TTGGGT`	1	--	ng3¹		2	NS	88
	rs35221575^1,2	C,F	47789823(+)	`CTGCAG/ACATTG`	1	V/A	mis¹		5	NA EU EA WA	482
--	rs28367882^1,2	C,F	47790771(+)	`GGAGCC/ACCTGC`	1	V/G	mis¹ ese³		2	NS	90
--	rs45459094^1,2	F	47776132(-)	`CTTGGT/CTAAAA`	1	--	ng5¹		2	NS	84
--	rs45513692^1,2	F	47776609(-)	`CATGAG/ATATTC`	1	--	ut3¹		2	NS	92
--	rs45551231^1,2	F	47777216(-)	`GATCAC/TGCCAC`	1	--	ut3¹		2	NS	94
--	rs45463194^1,2	F	47792749(-)	`TGGGTG/TACCTC`	1	--	ng3¹		2	NS	92

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HapMap Linkage Disequilibrium images for CEACAM8 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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4 Novoseek disease relationships for CEACAM8 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
myeloid leukemia chronic	38.49	1	2208113 (1)
osteoarthritis	14.29	1	7614736 (1)
inflammation	5.11	1	1964640 (1)
tumors	0.00	1	7591230 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/42 PubMed articles for CEACAM8 gene (see all 42 ):

Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. (PubMed id 2208113)^{1, 2, 3, 4} Berling B.... Zimmermann W. (1990)
Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. (PubMed id 2306228)^{2, 3, 4} Arakawa F....Matsuoka Y. (1990)
Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. (PubMed id 9427723)^{1, 3, 4} Eades-Perner A.... Zimmermann W. (1998)
Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PubMed id 1427854)^{1, 3, 4} Khan W.N....Hammarstroem S. (1992)
Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{3, 4} Ramachandran P....Loo J.A. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{3, 4} Grimwood J.... Lucas S.M. (2004)
Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. (PubMed id 12379336)^{1, 3} Zhao L....Venge P. (2002)
Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. (PubMed id 10520185)^{1, 3} Torsteinsdottir I....Hakansson L. (1999)
Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. (PubMed id 11994468)^{1, 3} Singer B.B....Obrink B. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1088	HGNC: 1820	AceView: CEACAM8	Ensembl:ENSG00000124469	euGenes: HUgn1088
ECgene: CEACAM8	H-InvDB: CEACAM8

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CEACAM8	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CEACAM8
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CEACAM8:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CEACAM8-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CEACAM8		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for CEACAM8		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Antibodies for CEACAM8

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CEACAM8 Gene

protein-coding GIFtS: 53

Aliases &
Descriptions
for CEACAM8

Summaries
for CEACAM8

Genomic Location
for CEACAM8

Proteins
for CEACAM8

Protein Domains/
Families
for CEACAM8

Gene Function
for CEACAM8

Pathways & Interactions
for CEACAM8

Drugs & Compounds
for CEACAM8

Transcripts
for CEACAM8

Expression
for CEACAM8

Orthologs
for CEACAM8

Paralogs
for CEACAM8

SNPs/Variants
for CEACAM8

Disorders & Mutations
for CEACAM8

Medical News
for CEACAM8

Publications
for CEACAM8

Search for CEACAM8

Genome Databases showing CEACAM8

Other Databases showing CEACAM8

Specialized Databases showing CEACAM8

Licensable Technologies
for CEACAM8

Services
for CEACAM8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CEACAM8 Gene

protein-coding GIFtS: 53

Aliases & Descriptionsfor CEACAM8

Summariesfor CEACAM8

Genomic Locationfor CEACAM8

Proteinsfor CEACAM8

Protein Domains/Familiesfor CEACAM8

Gene Functionfor CEACAM8

Pathways & Interactionsfor CEACAM8

Drugs & Compoundsfor CEACAM8

Transcriptsfor CEACAM8

Expression for CEACAM8

Orthologsfor CEACAM8

Paralogsfor CEACAM8

SNPs/Variantsfor CEACAM8

Disorders & Mutationsfor CEACAM8

Medical Newsfor CEACAM8

Publicationsfor CEACAM8

Search for CEACAM8

Genome Databases showing CEACAM8

Other Databases showing CEACAM8

Specialized Databases showing CEACAM8

Licensable Technologiesfor CEACAM8

Servicesfor CEACAM8

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CEACAM8

Summaries
for CEACAM8

Genomic Location
for CEACAM8

Proteins
for CEACAM8

Protein Domains/
Families
for CEACAM8

Gene Function
for CEACAM8

Pathways & Interactions
for CEACAM8

Drugs & Compounds
for CEACAM8

Transcripts
for CEACAM8

Expression
for CEACAM8

Orthologs
for CEACAM8

Paralogs
for CEACAM8

SNPs/Variants
for CEACAM8

Disorders & Mutations
for CEACAM8

Medical News
for CEACAM8

Publications
for CEACAM8

Licensable Technologies
for CEACAM8

Services
for CEACAM8