Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM8 Gene

protein-coding   GIFtS: 53
GCID: GC19M043084

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...


(Previous symbol: CGM6)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 81 2     CD66b2
CGM61 2 3     CD672
Carcinoembryonic Antigen CGM62 3     NCA-952
Non-Specific Cross-Reacting Antigen NCA-952 3     Carcinoembryonic Antigen Gene Family Member 62
CD67 Antigen2 3     CD66b Antigen3

External Ids:    HGNC: 18201   Entrez Gene: 10882   Ensembl: ENSG000001244697   UniProtKB: P319973   
ORGUL members:         
NONCODE14:n342391      

Export aliases for CEACAM8 gene to outside databases

Previous GC identifers: GC19M043731 GC19M043476 GC19M047760 GC19M047776 GC19M039517


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEACAM8 Gene: 
CEACAM8 (carcinoembryonic antigen-related cell adhesion molecule 8) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CEACAM8 include paroxysmal nocturnal hemoglobinuria, and infective endocarditis. An important paralog of this gene is PSG9.

Gene Wiki entry for CEACAM8 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM8 gene promoter:
         AML1a   ATF-2   NRSF form 1   NF-kappaB   NRSF form 2   CREB   deltaCREB   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM8 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEACAM8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CEACAM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043084:  view genomic region     (about GC identifiers)

Start:
43,084,393 bp from pter      End:
43,099,207 bp from pter
Size:
14,815 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEAM8_HUMAN, P31997 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 8 precursor  
Size: 349 amino acids; 38154 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
1 PDB 3D structure from and Proteopedia for CEACAM8:
2DKS (3D)    
Secondary accessions: O60399 Q16574

Explore the universe of human proteins at neXtProt for CEACAM8: NX_P31997

Explore proteomics data for CEACAM8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P31997

  • CEACAM8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEACAM8 Protein Expression
    REFSEQ proteins: NP_001807.2  
    ENSEMBL proteins: 
     ENSP00000244336   ENSP00000472166  

    Human Recombinant Protein Products for CEACAM8: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CEACAM8
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CEACAM8
    GenScript Custom Purified and Recombinant Proteins Services for CEACAM8
    Novus Biologicals CEACAM8 Protein
    Novus Biologicals CEACAM8 Lysate
    Sino Biological Recombinant Protein for CEACAM8
    Sino Biological Cell Lysate for CEACAM8 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CEACAM8 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS2306228
    GO:0005886plasma membrane TAS--
    GO:0005887integral to plasma membrane TAS2208113
    GO:0031225anchored to membrane IEA--

    CEACAM8 for ontologies           About GeneDecksing



    CEACAM8 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CEACAM8 (CEACAM-8/CD66b)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CEACAM8
    GenScript Custom Superior Antibodies Services for CEACAM8
    Novus Biologicals CEACAM8 Antibodies
    Abcam antibodies for CEACAM8
    Cloud-Clone Corp. Antibodies for CEACAM8 
    ThermoFisher Antibodies for CEACAM8
    LSBio Antibodies in human, mouse, rat for CEACAM8 

    Assay Products for CEACAM8: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CEACAM8
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CEACAM8
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CEACAM8 
    Cloud-Clone Corp. CLIAs for CEACAM8


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P31997

    ProtoNet protein and cluster: P31997

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CEAM8_HUMAN, P31997
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CEACAM8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for CEACAM8:
    carcinoembryonic antigen-related cell adhesion molecule 8 (see CEA@,PSG@)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CEACAM8 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEACAM8 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CEACAM8

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEACAM8 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEACAM8 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEACAM8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CEACAM8
    SwitchGear 3'UTR luciferase reporter plasmidCEACAM8 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CEACAM8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEACAM8

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEACAM8
    Sirion Biotech Customized adenovirus for overexpression of CEACAM8

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CEACAM8 (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEACAM8 (NM_001816)
    Sino Biological Human cDNA Clone for CEACAM8
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM8
    Sirion Biotech Customized lentivirus for stable overexpression of CEACAM8 
                         Customized lentivirus expression plasmids for stable overexpression of CEACAM8 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CEACAM8
    Search LifeMap BioReagents cell lines for CEACAM8
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CEACAM8

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    3 Interacting proteins for CEACAM8 (P319973 ENSP000002443364) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEACAM1P136883, ENSP000001615594I2D: score=3 STRING: ENSP00000161559
    CEACAM6P401993, ENSP000001997644I2D: score=1 STRING: ENSP00000199764
    ITGAMP112153I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955immune response TAS2208113

    CEACAM8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CEACAM8 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEACAM8 (CEAM8)

    1 Novoseek inferred chemical compound relationship for CEACAM8 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    fmlp 39.3 4 8977287 (2)

    Search CenterWatch for drugs/clinical trials and news about CEACAM8 / CEAM8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEACAM8 gene: 
    NM_001816.3  

    Unigene Cluster for CEACAM8:

    Carcinoembryonic antigen-related cell adhesion molecule 8
    Hs.41  [show with all ESTs]
    Unigene Representative Sequence: NM_001816
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000244336(uc002oud.2) ENST00000599005
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEACAM8
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CEACAM8
    SwitchGear 3'UTR luciferase reporter plasmidCEACAM8 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CEACAM8
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEACAM8
    Clone
    Products:
         
    OriGene clones in human, mouse for CEACAM8 (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEACAM8 (NM_001816)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM8
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM8
    Sirion Biotech Customized lentivirus for stable overexpression of CEACAM8 
                         Customized lentivirus expression plasmids for stable overexpression of CEACAM8 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CEACAM8
    OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM8
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CEACAM8
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM8
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM8

    Additional mRNA sequence: 

    AK297012.1 AK312652.1 BC026263.1 D90064.1 M33326.1 X52378.1 

    5 DOTS entries:

    DT.307942  DT.100822610  DT.121424607  DT.92414191  DT.95146984 

    22 AceView cDNA sequences:

    BC026263 NM_001816 X52378 D90064 M33326 BF892544 BF923154 BF891891 
    BF925283 BI023346 BF925291 BF925284 BF894287 BF898032 BQ336330 BF925290 
    BF898025 BF904943 BQ336337 BI019240 AW844115 BF336867 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEACAM8 expression in normal human tissues (normalized intensities)      CEACAM8 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEACAM8 Expression
    About this image


    CEACAM8 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 6 entries
             Granulocytes-like cells ( Generation of hematopoietic progenitor cells and matured...
             Bone Marrow CD33+ Cells   
             neutrophils   
     
     Bone (Muscoskeletal System)    fully expand to see all 3 entries
             Bone Marrow
             bone marrow   
     
     Lung (Respiratory System)
             alveolar macrophages   

    See CEACAM8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEACAM8

    SOURCE GeneReport for Unigene cluster: Hs.41

    UniProtKB/Swiss-Prot: CEAM8_HUMAN, P31997
    Tissue specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow

        SABiosciences Custom PCR Arrays for CEACAM8
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CEACAM8
    OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM8
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CEACAM8
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM8
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM8
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
      --

    ENSEMBL Gene Tree for CEACAM8 (if available)
    TreeFam Gene Tree for CEACAM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEACAM8 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  PSG62  ENSG000002678812  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  CEACAM32  PSG72  
    18/23 SIMAP similar genes for CEACAM8 using alignment to 3 protein entries:     CEAM8_HUMAN (see all proteins) (see all similar genes):
    CEACAM1    CEACAM6    CEA    CEACAM5    CEACAM3    CEACAM7
    CEACAM4    PSG    PSG11    PSG2    PSG1    PSGII
    CEACAM21    PSG5    PSG8    SP1    PSG4    PSG6

    CEACAM8 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CEACAM8
    PGOHUM00000234326


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    5 SNPs in CEACAM8 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0498504
    ----see VAR_0498502 A V mis40--------
    VAR_0498494
    ----see VAR_0498492 G V mis40--------
    VAR_0498514
    ----see VAR_0498512 L V mis40--------
    VAR_0498524
    ----see VAR_0498522 I M mis40--------
    VAR_0117214
    ----see VAR_0117212 R K mis40--------

    HapMap Linkage Disequilibrium report for CEACAM8 (43084393 - 43099207 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CEACAM8:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv15e196CNV Deletion17116639
    esv2422471CNV Deletion17116639
    nsv482221CNV Gain20164927
    nsv526186CNV Gain19592680
    dgv1087e1CNV Complex17122850
    dgv1086e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CEACAM8
    DNA2.0 Custom Variant and Variant Library Synthesis for CEACAM8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    18 diseases for CEACAM8:    About MalaCards
    paroxysmal nocturnal hemoglobinuria    infective endocarditis    endocarditis    reactive arthritis
    chronic myeloid leukemia    hemoglobinuria    osteomyelitis    myelofibrosis
    osteoarthritis    acute lymphoblastic leukemia    myeloid leukemia    lymphoblastic leukemia
    arthritis    colon cancer    rheumatoid arthritis    leukemia
    endotheliitis    pancreatitis


    CEACAM8 for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CEACAM8 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    myeloid leukemia chronic 37.6 1 2208113 (1)
    osteoarthritis 12.8 1 7614736 (1)
    inflammation 3.35 1 1964640 (1)
    tumors 0 1 7591230 (1)


    Export disorders for CEACAM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEACAM8 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with CEACAM8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. (PubMed id 2208113)1, 2, 3, 9 Berling B.... Zimmermann W. (1990)
    2. Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. (PubMed id 2306228)1, 2, 3 Arakawa F.... Matsuoka Y. (1990)
    3. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. (PubMed id 9427723)1, 2, 9 Eades-Perner A.... Zimmermann W. (1998)
    4. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PubMed id 1427854)1, 2, 9 Khan W.N....Hammarstroem S. (1992)
    5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (2004)
    8. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. (PubMed id 12379336)1, 9 Zhao L....Venge P. (2002)
    9. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. (PubMed id 10520185)1, 9 Torsteinsdottir I....Hakansson L. (1999)
    10. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. (PubMed id 11994468)1, 9 Singer B.B....Obrink B. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1088 HGNC: 1820 AceView: CEACAM8 Ensembl:ENSG00000124469 euGenes: HUgn1088
    ECgene: CEACAM8 H-InvDB: CEACAM8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEACAM8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEACAM8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEACAM8 gene:
    Search GeneIP for patents involving CEACAM8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CEACAM8 (CEACAM-8/CD66b)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CEACAM8  
     OriGene qPCR primer pairs and template standards for CEACAM8   OriGene Protein Over-expression Lysate for CEACAM8  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CEACAM8  
     OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM8   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CEACAM8   OriGene Custom Protein Services for CEACAM8  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEACAM8
     QIAGEN SeqTarget long-range PCR primers for resequencing CEACAM8
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM8
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEACAM8
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM8
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM8
     GenScript Custom Purified and Recombinant Proteins Services for CEACAM8 GenScript cDNA clones with any tag delivered in your preferred vector for CEACAM8
     GenScript Custom Assay Services for CEACAM8 GenScript Custom Superior Antibodies Services for CEACAM8
     GenScript Custom overexpressing Cell Line Services for CEACAM8 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CEACAM8 promoter
     Search Chromatin IP Primers for CEACAM8
     RT2 qPCR Primer Assay in human, mouse / rat CEACAM8
     GNC Network for CEACAM8
     SABiosciences Custom PCR Arrays for CEACAM8
     Search Tocris compounds for CEACAM8 (CEAM8)
     Proteins and Antibodies for CEACAM8
     Cell Lysates for CEACAM8
     cDNA Clones for CEACAM8
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CEACAM8 antibodies
     CEACAM8 proteins
     CEACAM8 lysates
     Antibodies for CEACAM8
     See all of Abcam's Antibodies, Kits and Proteins for CEACAM8
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CEACAM8
     Antibodies for CEACAM8
     ELISAs for CEACAM8
     CLIAs for CEACAM8
     Search LifeMap BioReagents cell lines for CEACAM8
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM8
     SwitchGear 3'UTR luciferase reporter plasmids for CEACAM8
     SwitchGear Promoter luciferase reporter plasmids for CEACAM8
     ThermoFisher Antibodies for CEACAM8
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM8
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CEACAM8
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CEACAM8
    Customized:
     lentivirus for stable overexpression of CEACAM8
     lentivirus expression plasmids for stable overexpression of CEACAM8
     adenovirus for overexpression of CEACAM8
     LSBio Antibodies in human, mouse, rat for CEACAM8
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CEACAM8 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4