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Aliases for CEACAM8 Gene

Aliases for CEACAM8 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 8 2 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 2 5
  • Non-Specific Cross-Reacting Antigen NCA-95 3 4
  • Carcinoembryonic Antigen CGM6 3 4
  • CD67 Antigen 3 4
  • CGM6 3 4
  • Carcinoembryonic Antigen Gene Family Member 6 3
  • CD66b Antigen 4
  • NCA-95 3
  • CD66b 3
  • CD67 3

External Ids for CEACAM8 Gene

Previous HGNC Symbols for CEACAM8 Gene

  • CGM6

Previous GeneCards Identifiers for CEACAM8 Gene

  • GC19M043731
  • GC19M043476
  • GC19M047760
  • GC19M047776
  • GC19M043084
  • GC19M039517

Summaries for CEACAM8 Gene

GeneCards Summary for CEACAM8 Gene

CEACAM8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Endocarditis and Shwartzman Phenomenon. Among its related pathways are Platelet activation, signaling and aggregation and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM4.

Gene Wiki entry for CEACAM8 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM8 Gene

Genomics for CEACAM8 Gene

Regulatory Elements for CEACAM8 Gene

Enhancers for CEACAM8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEACAM8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM8 Gene

Chromosome:
19
Start:
42,580,241 bp from pter
End:
42,740,384 bp from pter
Size:
160,144 bases
Orientation:
Minus strand

Genomic View for CEACAM8 Gene

Genes around CEACAM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM8 Gene

Proteins for CEACAM8 Gene

  • Protein details for CEACAM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31997-CEAM8_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 8
    Protein Accession:
    P31997
    Secondary Accessions:
    • O60399
    • Q16574

    Protein attributes for CEACAM8 Gene

    Size:
    349 amino acids
    Molecular mass:
    38154 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CEACAM8 Gene

neXtProt entry for CEACAM8 Gene

Proteomics data for CEACAM8 Gene at MOPED

Post-translational modifications for CEACAM8 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 115, Asn 152, Asn 173, Asn 197, Asn 224, Asn 256, Asn 274, Asn 288, and Asn 309
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CEACAM8 (CEACAM-8/CD66b)
  • Abcam antibodies for CD66b

No data available for DME Specific Peptides for CEACAM8 Gene

Domains & Families for CEACAM8 Gene

Protein Domains for CEACAM8 Gene

Graphical View of Domain Structure for InterPro Entry

P31997

UniProtKB/Swiss-Prot:

CEAM8_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM8: view

Function for CEACAM8 Gene

Molecular function for CEACAM8 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 8 (see CEA@,PSG@)
genes like me logo Genes that share phenotypes with CEACAM8: view

Animal Model Products

CRISPR Products

miRNA for CEACAM8 Gene

miRTarBase miRNAs that target CEACAM8

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM8 Gene

Localization for CEACAM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM8 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM8 Gene COMPARTMENTS Subcellular localization image for CEACAM8 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 2
vacuole 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane TAS 2208113
GO:0070062 extracellular exosome IDA 23533145
genes like me logo Genes that share ontologies with CEACAM8: view

Pathways & Interactions for CEACAM8 Gene

genes like me logo Genes that share pathways with CEACAM8: view

Interacting Proteins for CEACAM8 Gene

Gene Ontology (GO) - Biological Process for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CEACAM8: view

No data available for SIGNOR curated interactions for CEACAM8 Gene

Drugs & Compounds for CEACAM8 Gene

(1) Additional Compounds for CEACAM8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM8: view

Transcripts for CEACAM8 Gene

mRNA/cDNA for CEACAM8 Gene

Unigene Clusters for CEACAM8 Gene

Carcinoembryonic antigen-related cell adhesion molecule 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM8 Gene

No ASD Table

Relevant External Links for CEACAM8 Gene

GeneLoc Exon Structure for
CEACAM8
ECgene alternative splicing isoforms for
CEACAM8

Expression for CEACAM8 Gene

mRNA expression in normal human tissues for CEACAM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM8 Gene

This gene is overexpressed in Whole Blood (x46.9).

Protein differential expression in normal tissues from HIPED for CEACAM8 Gene

This gene is overexpressed in Neutrophil (45.4) and Blymphocyte (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEACAM8 Gene



SOURCE GeneReport for Unigene cluster for CEACAM8 Gene Hs.41

mRNA Expression by UniProt/SwissProt for CEACAM8 Gene

P31997-CEAM8_HUMAN
Tissue specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
genes like me logo Genes that share expression patterns with CEACAM8: view

Protein tissue co-expression partners for CEACAM8 Gene

- Elite partner

Primer Products

Orthologs for CEACAM8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM8 35
  • 99.43 (n)
  • 99.71 (a)
CEACAM8 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
ManyToMany
CEACAM1 36
  • 35 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 38 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg26 36
  • 17 (a)
ManyToMany
Species with no ortholog for CEACAM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM8 Gene

ENSEMBL:
Gene Tree for CEACAM8 (if available)
TreeFam:
Gene Tree for CEACAM8 (if available)

Paralogs for CEACAM8 Gene

Pseudogenes.org Pseudogenes for CEACAM8 Gene

genes like me logo Genes that share paralogs with CEACAM8: view

Variants for CEACAM8 Gene

Sequence variations from dbSNP and Humsavar for CEACAM8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_011721 -
VAR_049849 -
VAR_049850 -
VAR_049851 -
VAR_049852 -

Structural Variations from Database of Genomic Variants (DGV) for CEACAM8 Gene

Variant ID Type Subtype PubMed ID
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1086e1 CNV Complex 17122850
dgv1087e1 CNV Complex 17122850
nsv482221 CNV Gain 20164927

Variation tolerance for CEACAM8 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.66% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEACAM8 Gene

Disorders for CEACAM8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEACAM8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endocarditis
shwartzman phenomenon
  • shwartzman reaction
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CEACAM8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM8
genes like me logo Genes that share disorders with CEACAM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM8 Gene

Publications for CEACAM8 Gene

  1. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. (PMID: 2208113) Berling B. … Zimmermann W. (Cancer Res. 1990) 2 3 4 23 67
  2. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. (PMID: 11994468) Singer B.B. … Obrink B. (J. Immunol. 2002) 3 23
  3. Purification and characterization of a 95-kDa protein--carcinoembryonic antigen-related cell adhesion molecule 8--from normal human granulocytes. (PMID: 12379336) Zhao L. … Venge P. (J. Immunol. Methods 2002) 3 23
  4. Enhanced expression of integrins and CD66b on peripheral blood neutrophils and eosinophils in patients with rheumatoid arthritis, and the effect of glucocorticoids. (PMID: 10520185) TorsteinsdA^ttir I. … HAYkansson L. (Scand. J. Immunol. 1999) 3 23
  5. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. (PMID: 9427723) Eades-Perner A. … Zimmermann W. (Blood 1998) 3 23

Products for CEACAM8 Gene

Sources for CEACAM8 Gene

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