Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CEACAM8 Gene

Aliases for CEACAM8 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 8 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 8 2 3
  • Non-Specific Cross-Reacting Antigen NCA-95 3 4
  • Carcinoembryonic Antigen CGM6 3 4
  • CD67 Antigen 3 4
  • CGM6 3 4
  • Carcinoembryonic Antigen Gene Family Member 6 3
  • CD66b Antigen 4
  • NCA-95 3
  • CD66b 3
  • CD67 3

External Ids for CEACAM8 Gene

Previous HGNC Symbols for CEACAM8 Gene

  • CGM6

Previous GeneCards Identifiers for CEACAM8 Gene

  • GC19M043731
  • GC19M043476
  • GC19M047760
  • GC19M047776
  • GC19M043084
  • GC19M039517

Summaries for CEACAM8 Gene

GeneCards Summary for CEACAM8 Gene

CEACAM8 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 8) is a Protein Coding gene. Diseases associated with CEACAM8 include Endocarditis and Shwartzman Phenomenon. Among its related pathways are Immune System and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM1.

Gene Wiki entry for CEACAM8 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM8 Gene

Genomics for CEACAM8 Gene

Regulatory Elements for CEACAM8 Gene

Enhancers for CEACAM8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F042567 1.1 Ensembl ENCODE 11.5 +27.3 27298 1.5 BCOR CTCF ZNF384 ZNF2 RAD21 ZNF121 ZNF366 SMC3 ZNF143 PRDM10 CEACAM8 CXCL17 CEACAMP2
GH19F042276 1.7 FANTOM5 Ensembl ENCODE 5.6 +313.1 313142 11.1 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZNF416 ZNF143 ZNF526 ZNF574 CCDC97 CEACAMP1 CEACAMP10 ENSG00000278239 RPS19 DEDD2 MEGF8 CEACAM8
GH19F042267 0.9 FANTOM5 ENCODE 3.9 +324.2 324168 6.9 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A YBX1 FEZF1 ZNF2 ZNF526 DEDD2 CCDC97 CEACAM3 CIC PRR19 PAFAH1B3 GSK3A ZNF574 DMRTC2
GH19F042460 0.3 FANTOM5 3.2 +134.4 134400 0.4 CXCL17 CEACAM8 DEDD2 PIR51613
GH19F042205 1.5 FANTOM5 Ensembl ENCODE 2.1 +387.6 387639 2.9 KLF17 ZNF2 ZEB1 ZNF121 GLIS2 ZNF366 FOS CREM EGR2 ZNF362 GRIK5 LOC100505622 GSK3A DEDD2 ARHGEF1 CEACAM8 POU2F2 CEACAM3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CEACAM8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM8 Gene

Chromosome:
19
Start:
42,580,241 bp from pter
End:
42,595,055 bp from pter
Size:
14,815 bases
Orientation:
Minus strand

Genomic View for CEACAM8 Gene

Genes around CEACAM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM8 Gene

Proteins for CEACAM8 Gene

  • Protein details for CEACAM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P31997-CEAM8_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 8
    Protein Accession:
    P31997
    Secondary Accessions:
    • O60399
    • Q16574

    Protein attributes for CEACAM8 Gene

    Size:
    349 amino acids
    Molecular mass:
    38154 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CEACAM8 Gene

neXtProt entry for CEACAM8 Gene

Post-translational modifications for CEACAM8 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 115, Asn 152, Asn 173, Asn 197, Asn 224, Asn 256, Asn 274, Asn 288, and Asn 309
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CEACAM8 (CEACAM-8/CD66b)
  • Abcam antibodies for CEACAM8

No data available for DME Specific Peptides for CEACAM8 Gene

Domains & Families for CEACAM8 Gene

Protein Domains for CEACAM8 Gene

Graphical View of Domain Structure for InterPro Entry

P31997

UniProtKB/Swiss-Prot:

CEAM8_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM8: view

Function for CEACAM8 Gene

Molecular function for CEACAM8 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 8 (see CEA@,PSG@)

Gene Ontology (GO) - Molecular Function for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 11994468
genes like me logo Genes that share ontologies with CEACAM8: view
genes like me logo Genes that share phenotypes with CEACAM8: view

Animal Model Products

miRNA for CEACAM8 Gene

miRTarBase miRNAs that target CEACAM8

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM8 Gene

Localization for CEACAM8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM8 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM8 Gene COMPARTMENTS Subcellular localization image for CEACAM8 gene
Compartment Confidence
extracellular 5
plasma membrane 5
lysosome 2
vacuole 2
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 2208113
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM8: view

Pathways & Interactions for CEACAM8 Gene

genes like me logo Genes that share pathways with CEACAM8: view

Gene Ontology (GO) - Biological Process for CEACAM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006955 immune response TAS 2208113
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CEACAM8: view

No data available for SIGNOR curated interactions for CEACAM8 Gene

Drugs & Compounds for CEACAM8 Gene

(1) Additional Compounds for CEACAM8 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM8: view

Transcripts for CEACAM8 Gene

mRNA/cDNA for CEACAM8 Gene

Unigene Clusters for CEACAM8 Gene

Carcinoembryonic antigen-related cell adhesion molecule 8:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM8 Gene

No ASD Table

Relevant External Links for CEACAM8 Gene

GeneLoc Exon Structure for
CEACAM8
ECgene alternative splicing isoforms for
CEACAM8

Expression for CEACAM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM8 Gene

This gene is overexpressed in Whole Blood (x46.9).

Protein differential expression in normal tissues from HIPED for CEACAM8 Gene

This gene is overexpressed in Neutrophil (45.4) and Blymphocyte (13.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEACAM8 Gene



Protein tissue co-expression partners for CEACAM8 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CEACAM8 Gene:

CEACAM8

SOURCE GeneReport for Unigene cluster for CEACAM8 Gene:

Hs.41

mRNA Expression by UniProt/SwissProt for CEACAM8 Gene:

P31997-CEAM8_HUMAN
Tissue specificity: Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.
genes like me logo Genes that share expression patterns with CEACAM8: view

Primer Products

Orthologs for CEACAM8 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM8 34 35
  • 99.43 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 38 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CEACAM1 35
  • 35 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg26 35
  • 17 (a)
ManyToMany
Species where no ortholog for CEACAM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM8 Gene

ENSEMBL:
Gene Tree for CEACAM8 (if available)
TreeFam:
Gene Tree for CEACAM8 (if available)

Paralogs for CEACAM8 Gene

Pseudogenes.org Pseudogenes for CEACAM8 Gene

genes like me logo Genes that share paralogs with CEACAM8: view

Variants for CEACAM8 Gene

Sequence variations from dbSNP and Humsavar for CEACAM8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10402245 -- 42,591,628(+) TTTGC(A/G)AATTG intron-variant
rs10405410 -- 42,588,353(+) TCCTC(C/T)CATTT intron-variant, reference, missense, utr-variant-3-prime
rs10406307 -- 42,588,623(+) GAAGA(A/G)AGTCT intron-variant
rs10413332 -- 42,589,566(+) AGGGT(C/T)CTGTT intron-variant, reference, synonymous-codon
rs10414843 -- 42,584,278(+) TTGGC(C/T)CTCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM8 Gene

Variant ID Type Subtype PubMed ID
dgv15e196 CNV deletion 17116639
esv2422471 CNV deletion 17116639
esv2758763 CNV gain+loss 17122850
esv3583425 CNV loss 25503493
nsv1058936 CNV gain 25217958
nsv1064734 CNV gain 25217958
nsv482221 CNV gain 20164927
nsv526186 CNV gain 19592680
nsv963055 CNV duplication 23825009
nsv978823 CNV duplication 23825009

Variation tolerance for CEACAM8 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM8 Gene

Disorders for CEACAM8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEACAM8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
endocarditis
shwartzman phenomenon
  • shwartzman reaction
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CEACAM8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM8
genes like me logo Genes that share disorders with CEACAM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM8 Gene

Publications for CEACAM8 Gene

  1. Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow. (PMID: 2208113) Berling B. … Zimmermann W. (Cancer Res. 1990) 2 3 4 22 64
  2. Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes. (PMID: 9427723) Eades-Perner A. … Zimmermann W. (Blood 1998) 3 4 22 64
  3. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PMID: 1427854) Khan W.N. … Hammarstroem S. (Genomics 1992) 3 4 22 64
  4. Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family. (PMID: 2306228) Arakawa F. … Matsuoka Y. (Biochem. Biophys. Res. Commun. 1990) 2 3 4 64
  5. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PMID: 16740002) Ramachandran P. … Loo J.A. (J. Proteome Res. 2006) 3 4 64

Products for CEACAM8 Gene

Sources for CEACAM8 Gene

Content
Loading form....