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Aliases & Descriptions for CEACAM7
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Carcinoembryonic antigen CGM2 3 | | carcinoembryonic antigen gene family member 2 2 | | carcinoembryonic antigen-related cell adhesion molecule 7 2 |
|
| | Search outside databases for aliases for CEACAM7 genePrevious GC identifers: GC19M042816 GC19M042568 GC19M046853 |
Summaries for CEACAM7(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Gene Wiki entry for CEACAM7 |
Genomic Location for CEACAM7
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CEACAM7 gene 
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2CEACAM7 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M046869:
(about GC identifiers)
Start:
|
46,869,073 bp from pter |
End:
|
46,884,039 bp from pter |
Size:
|
14,967 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for CEACAM7
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002 (See
protein sequence)Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 7 precursor Size: 265 amino acids; 29379 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
Secondary accessions: O15148 O15149 Q0VAC1 Q13983 Q9UPJ2Alternative splicing: 2 isoforms: Q14002-1 Q14002-2 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_008821.1
ENSEMBL proteins: ENSP00000343286 ENSP00000006724 ENSP00000385932
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CEACAM7: Assays for CEACAM7: | Protein
Domains/ Families for CEACAM7(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q14002
ProtoNet protein and cluster: Q14002 2 Blocks protein families: IPB003599 Immunoglobulin subtype IPB013098 Immunoglobulin I-set
UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domainSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for CEACAM7
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006890
Applied Biosystems Silencer® siRNAs for CEACAM7
Sigma-Aldrich siRNA and siRNA Panels for CEACAM7  Sigma-Aldrich shRNA for CEACAM7  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006890                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006890                                  untagged cDNA clone in CMV expression vector: NM_006890 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_006890
Genatlas biochemistry entry for CEACAM7:carcinoembryonic antigen-related cell adhesion molecule 7 (see CEA@) | Pathways & Interactions for CEACAM7
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Interacting protein for CEACAM7 (ENSP000000067243) via UniProtKB, MINT, and/or STRINGAbout this table
|
Drugs & Compounds for CEACAM7(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CEACAM7 5 Novoseek chemical compound relationships for CEACAM7 gene
About this table
|
Transcripts for CEACAM7(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006890
Sigma-Aldrich siRNA and siRNA Panels for CEACAM7  Sigma-Aldrich shRNA for CEACAM7  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_006890 REFSEQ mRNAs for CEACAM7 gene: NM_006890.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_006890               OriGene GFP tagged cDNA clone in CMV expression vector: NM_006890                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_006890                                  untagged cDNA clone in CMV expression vector: NM_006890  Additional cDNA sequence: AF006622.1 AF006623.1 AK292213.1 AK296634.1 AK311285.1 AK313108.1 BC121132.2 L31792.1 X98311.1 6 DOTS entries: DT.40115478 DT.121504120 DT.92039756 DT.310603 DT.121504116 DT.121504119 24/49 AceView cDNA sequences (see all 49
):AI281195 AI304573 AU076440 AI695136 AW780234 AW780407 AA577615 AI707997 AI720037 AA327251 X98311 T29474 BX479917 NM_006890 BX480010 AU099384 L31792 AI833234 AW468781 AF006622 AW951207 AA527591 BX480021 BX505824
highest scoring ESTs for CEACAM7:X98311 AF006622 AF006623 AL602909 AU076440 AU099384 AW861138 BX479917 BX480010 BX480021 Unigene Cluster for CEACAM7: Carcinoembryonic antigen-related cell adhesion molecule 7 Hs.74466 [show with all ESTs]Unigene Representative Sequence: X98311
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM7
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for CEACAM7
3 Ensembl transcripts including schematic representations: ENST00000338196
ENST00000006724
ENST00000401731
|
Expression for CEACAM7
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CEACAM7 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CEACAM7
1 / 2 / 3 7 probe-sets matching CEACAM7 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.74466
Expression variation in blood from EXPOLDB for CEACAM7 UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002Tissue specificity: Strongly down-regulated in colonic adenocarcinomas |
Orthologs for CEACAM7
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CEACAM7 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
CEACAM71 |
-- |
carcinoembryonic antigen-related cell adhesion molecule more |
98.62(n) 98.11(a) |
468892 XM_524278.2 XP_524278.1 |
About this table Species with no ortholog for CEACAM7
ENSEMBL Gene Tree for CEACAM7 | Paralogs for CEACAM7(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CEACAM7 gene
- PSG52 PSG92 PSG82 PSG62 CEACAM52 PSG112 CEACAM12 CEACAM82
- PSG32 CEACAM62 PSG22 PSG72 PSG12
|
SNPs/Variants for CEACAM7(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CEACAM7 (up to first 250kb)
|
Disorders & Mutations for CEACAM7
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
| 10/61 Novoseek disease relationships for CEACAM7 gene (see all 61
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| adenocarcinoma |
83.06 |
123 |
11781517 (4), 10467024 (3), 1700970 (3), 9522212 (3) (see all 78) |
| colon adenocarcinoma |
71.72 |
12 |
9237098 (1), 10688120 (1), 7806520 (1), 8205554 (1) (see all 10) |
| cervical adenocarcinoma |
70.94 |
11 |
2258083 (2), 12647218 (2), 2153042 (2), 15297173 (2) (see all 7) |
| colorectal carcinoma |
63.48 |
35 |
8374868 (4), 15332370 (4), 2092570 (3), 9589054 (2) (see all 15) |
| colon tumor |
63.34 |
7 |
12743424 (2), 9056678 (2), 1998972 (1) |
| colorectal cancer |
62.47 |
30 |
11712806 (2), 2166552 (2), 18780338 (2), 1643605 (2) (see all 19) |
| colon carcinoma |
60.56 |
8 |
10472328 (2), 8453631 (1), 8317550 (1), 8168994 (1) (see all 6) |
| adenocarcinoma lung |
60.36 |
13 |
7789485 (6), 17219955 (2), 18931837 (2), 17941001 (1) |
| colon cancer |
59.20 |
14 |
10472328 (2), 10864342 (2), 1851587 (2), 2334536 (1) (see all 10) |
| tumors |
58.70 |
183 |
8265235 (6), 8683233 (6), 10472328 (5), 16425302 (5) (see all 79) |
About this table
|
Medical News for CEACAM7(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CEACAM7 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/207 PubMed articles for CEACAM7 gene (see all 207
):- CGM2, a member of the carcinoembryonic antigen gene family is down- regulated in colorectal carcinomas. (PubMed id 7806520)1, 2, 3, 4 Thompson J.... Willcocks T. (1994)
- Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. (PubMed id 9135022)1, 2, 3, 4 Thompson J....Zimmermann W. (1997)
- Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PubMed id 1427854)1, 3, 4 Khan W.N....Hammarstroem S. (1992)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)3, 4 Grimwood J.... Lucas S.M. (2004)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons. (PubMed id 2537643)3, 4 Thompson J.A.... Zimmermann W. (1989)
- Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. (PubMed id 10666389)1, 3 Scholzel S....Thompson J. (2000)
- Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat. (PubMed id 10436421)1, 3 Frangsmyr L....Hammarstrom S. (1999)
- Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas. (PubMed id 9533775)1, 3 Kinugasa T....Matsuoka Y. (1998)
|
Search for CEACAM7
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CEACAM7
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CEACAM7
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEACAM7(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CEACAM7(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CEACAM7:

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Incremental update: 13 Oct 2009
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