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CEACAM7 Gene

protein-coding   GIFtS: 54

GC19M046869
carcinoembryonic antigen-related cell adhesion molecule 7
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CGM2)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CEA 1, 2
CGM2 2, 3
Descriptions
Carcinoembryonic antigen CGM2 3
carcinoembryonic antigen gene family member 2 2
carcinoembryonic antigen-related cell adhesion molecule 7 2
External Ids
HGNC: 18191
Entrez Gene: 10872
UniProtKB: Q140023
Ensembl: ENSG000000073067
Search outside databases for aliases for CEACAM7 gene

Previous GC identifers: GC19M042816 GC19M042568 GC19M046853

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Gene Wiki entry for CEACAM7
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CEACAM7 gene  

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CEACAM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M046869:     (about GC identifiers)

Start:
46,869,073 bp from pter
End:
46,884,039 bp from pter
Size:
14,967 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 7 precursor  
Size: 265 amino acids; 29379 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
Secondary accessions: O15148 O15149 Q0VAC1 Q13983 Q9UPJ2
Alternative splicing: 2 isoforms:  Q14002-1   Q14002-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_008821.1  

    ENSEMBL proteins: 
    ENSP00000343286 ENSP00000006724 ENSP00000385932 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (CEACAM7)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane TAS7806520
    GO:0016021 integral to membrane TAS7806520
    GO:0031225 anchored to membrane IEA--
    About this table

    Antibodies for CEACAM7: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for CEACAM7
    R&D Systems Antibodies for CEACAM7 (CEACAM-7)
    Antibodies from Abcam (CEACAM7), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibody for CEACAM7

    Assays for CEACAM7: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR013106 Ig_V-set
     IPR007110 Ig-like
     IPR003599 Ig_sub


       GeneDecks  CEACAM7 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q14002

    ProtoNet protein and cluster: Q14002

    2 Blocks protein families:
    IPB003599 Immunoglobulin subtype
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CEACAM7)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006890

                  Applied Biosystems Silencer® siRNAs for CEACAM7

                  Sigma-Aldrich siRNA and siRNA Panels for CEACAM7  
                         Sigma-Aldrich shRNA for CEACAM7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006890
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006890
                                     untagged cDNA clone in CMV expression vector: NM_006890 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_006890

    Genatlas biochemistry entry for CEACAM7:
    carcinoembryonic antigen-related cell adhesion molecule 7 (see CEA@)
    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for CEACAM7 (ENSP000000067243) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APOHENSP000002059483STRING (score=.938)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for CEACAM7
    5 Novoseek chemical compound relationships for CEACAM7 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 723 64.90 5 7779533 (1), 1569446 (1), 1716293 (1), 12647218 (1) (see all 5)
    mucicarmine 52.96 1 9208972 (1)
    triiodothyronine 1.11 1 1851587 (1)
    progesterone 0.00 2 12493029 (1), 11444201 (1)
    thymidine 0.00 1 7923150 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (CEACAM7)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006890

                  Sigma-Aldrich siRNA and siRNA Panels for CEACAM7  
                         Sigma-Aldrich shRNA for CEACAM7  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_006890  

    REFSEQ mRNAs for CEACAM7 gene: 

    NM_006890.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_006890  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_006890
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_006890
                                     untagged cDNA clone in CMV expression vector: NM_006890 

    Additional cDNA sequence: 

    AF006622.1 AF006623.1 AK292213.1 AK296634.1 AK311285.1 AK313108.1 BC121132.2 L31792.1 
    X98311.1 

    6 DOTS entries:

    DT.40115478  DT.121504120  DT.92039756  DT.310603  DT.121504116  DT.121504119 

    24/49 AceView cDNA sequences (see all 49 ):

    AI281195 AI304573 AU076440 AI695136 AW780234 AW780407 AA577615 AI707997 
    AI720037 AA327251 X98311 T29474 BX479917 NM_006890 BX480010 AU099384 
    L31792 AI833234 AW468781 AF006622 AW951207 AA527591 BX480021 BX505824 

    highest scoring ESTs for CEACAM7:

    X98311 AF006622 AF006623 AL602909 AU076440 AU099384 AW861138 BX479917 BX480010 BX480021 

    Unigene Cluster for CEACAM7:

    Carcinoembryonic antigen-related cell adhesion molecule 7
    Hs.74466  [show with all ESTs]
    Unigene Representative Sequence: X98311


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM7

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                                                        
    SP2:                                                        -               
    SP3:                                                                        
    SP4:                                -     -                                 

    About this scheme

    ECgene alternative splicing isoforms for CEACAM7

    3 Ensembl transcripts including schematic representations:
    ENST00000338196  ENST00000006724  ENST00000401731  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CEACAM7 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for CEACAM7

    1 / 2 / 3

    7 probe-sets matching CEACAM7 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    160035_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X98311 1.00 1.00 1.00 1

    206198_s_at2, 3 U133-A 1 1.00 1.00 -- -- L31792 0.80 1.00 0.91 1

    206199_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006890 0.60 1.00 0.82 1

    211848_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF006623 0.80 1.00 0.91 1

    206198_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    206199_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    211848_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.74466

    Expression variation in blood from EXPOLDB for CEACAM7

    UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002
    Tissue specificity: Strongly down-regulated in colonic adenocarcinomas

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for CEACAM7 gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    CEACAM71   -- carcinoembryonic antigen-related cell adhesion molecule more 98.62(n)
    98.11(a)
    468892  XM_524278.2  XP_524278.1 
    About this table        Species with no ortholog for CEACAM7

    ENSEMBL Gene Tree for CEACAM7
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CEACAM7 gene
    PSG52  PSG92  PSG82  PSG62  CEACAM52  PSG112  CEACAM12  CEACAM82  
    PSG32  CEACAM62  PSG22  PSG72  PSG12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/124 NCBI SNPs in CEACAM7 are shown (see all 124 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 63)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs81024881,2
    A,C,F,H46882699(+) ATAGAA/TTCCTG 1 F/I mis1 ese312Minor allele frequency- N:0.00EA NA EU WA 1050
    rs104079991,2
    C,F,H46884675(+) GGAAGC/ACTCTG 1 -- ng316Minor allele frequency- A:0.18MN EA EU WA 1670
    rs104090401,2
    C,F,H46884884(+) CTTAGC/GAAGGC 1 -- ng3114Minor allele frequency- G:0.14EU EA WA NA MN 2308
    rs104113201,2
    A,F,H46885340(+) TTAAAT/ATAaaa 1 -- ng31 tfbs34Minor allele frequency- A:0.01EU EA WA 420
    rs169754781,2
    C,F,H46879556(+) CTCACA/GGCGGA 1 Y/H mis111Minor allele frequency- G:0.03NA EU EA WA 974
    rs356099351,2
    C,F46883933(+) ACCCCA/CTGGTC 1 R mis15Minor allele frequency- C:0.43NA EU EA WA 492
    rs104095791,2
    F,H46885328(+) CATGCA/Ggatgt 1 -- ng314Minor allele frequency- G:0.01EU EA WA 420
    rs72595321,2
    C,H46873190(+) TCAGAG/ACCATC 1 V/A mis14Minor allele frequency- A:0.00EU EA WA 420
    rs48035001,2
    F,H46885700(+) caaaaG/Cttata 1 -- ng314Minor allele frequency- C:0.01EU EA WA 420
    --
    rs10492341,2
    H46882846(-) AAGGGG/CAAAGG 1 Q/E mis1 trp35Minor allele frequency- C:0.00MN EU EA WA 590
    About this table

    HapMap Linkage Disequilibrium images for CEACAM7 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    10/61 Novoseek disease relationships for CEACAM7 gene (see all 61 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 83.06 123 11781517 (4), 10467024 (3), 1700970 (3), 9522212 (3) (see all 78)
    colon adenocarcinoma 71.72 12 9237098 (1), 10688120 (1), 7806520 (1), 8205554 (1) (see all 10)
    cervical adenocarcinoma 70.94 11 2258083 (2), 12647218 (2), 2153042 (2), 15297173 (2) (see all 7)
    colorectal carcinoma 63.48 35 8374868 (4), 15332370 (4), 2092570 (3), 9589054 (2) (see all 15)
    colon tumor 63.34 7 12743424 (2), 9056678 (2), 1998972 (1)
    colorectal cancer 62.47 30 11712806 (2), 2166552 (2), 18780338 (2), 1643605 (2) (see all 19)
    colon carcinoma 60.56 8 10472328 (2), 8453631 (1), 8317550 (1), 8168994 (1) (see all 6)
    adenocarcinoma lung 60.36 13 7789485 (6), 17219955 (2), 18931837 (2), 17941001 (1)
    colon cancer 59.20 14 10472328 (2), 10864342 (2), 1851587 (2), 2334536 (1) (see all 10)
    tumors 58.70 183 8265235 (6), 8683233 (6), 10472328 (5), 16425302 (5) (see all 79)
    About this table

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/207 PubMed articles for CEACAM7 gene (see all 207 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 1087 HGNC: 1819 AceView: CEACAM7 Ensembl:ENSG00000007306 euGenes: HUgn1087
    ECgene: CEACAM7 H-InvDB: CEACAM7
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for CEACAM7 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CEACAM7:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for CEACAM7-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
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