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Aliases for CEACAM7 Gene

Aliases for CEACAM7 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 2 3
  • Carcinoembryonic Antigen Gene Family Member 2 2 3
  • Carcinoembryonic Antigen CGM2 3 4
  • CGM2 3 4

External Ids for CEACAM7 Gene

Previous HGNC Symbols for CEACAM7 Gene

  • CGM2

Previous GeneCards Identifiers for CEACAM7 Gene

  • GC19M042816
  • GC19M042568
  • GC19M046853
  • GC19M046869
  • GC19M042178
  • GC19M038609

Summaries for CEACAM7 Gene

Entrez Gene Summary for CEACAM7 Gene

  • This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for CEACAM7 Gene

CEACAM7 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7) is a Protein Coding gene. Diseases associated with CEACAM7 include colon carcinoma in situ and paget disease, extramammary. An important paralog of this gene is CEACAM8.

Gene Wiki entry for CEACAM7 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM7 Gene

Genomics for CEACAM7 Gene

Regulatory Elements for CEACAM7 Gene

Genomic Location for CEACAM7 Gene

Chromosome:
19
Start:
41,673,307 bp from pter
End:
41,706,976 bp from pter
Size:
33,670 bases
Orientation:
Minus strand

Genomic View for CEACAM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM7 Gene

Proteins for CEACAM7 Gene

  • Protein details for CEACAM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14002-CEAM7_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 7
    Protein Accession:
    Q14002
    Secondary Accessions:
    • A8K848
    • O15148
    • O15149
    • Q0VAC1
    • Q13983
    • Q9UPJ2

    Protein attributes for CEACAM7 Gene

    Size:
    265 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEACAM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM7 Gene

Proteomics data for CEACAM7 Gene at MOPED

Post-translational modifications for CEACAM7 Gene

  • Glycosylation at Asn 57, Asn 85, Asn 105, Asn 112, Asn 174, Asn 183, and Asn 198
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM7 Gene

Antibody Products

No data available for DME Specific Peptides for CEACAM7 Gene

Domains & Families for CEACAM7 Gene

Protein Domains for CEACAM7 Gene

Suggested Antigen Peptide Sequences for CEACAM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14002

UniProtKB/Swiss-Prot:

CEAM7_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM7: view

Function for CEACAM7 Gene

Molecular function for CEACAM7 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 7 (see CEA@)

Gene Ontology (GO) - Molecular Function for CEACAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CEACAM7: view
genes like me logo Genes that share phenotypes with CEACAM7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM7 Gene

Localization for CEACAM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM7 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM7 Gene COMPARTMENTS Subcellular localization image for CEACAM7 gene
Compartment Confidence
plasma membrane 4

Gene Ontology (GO) - Cellular Components for CEACAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane TAS 7806520
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM7: view

Pathways & Interactions for CEACAM7 Gene

SuperPathways for CEACAM7 Gene

No Data Available

Interacting Proteins for CEACAM7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000006724%0d%0a9606.ENSP00000199764%0d%0a9606.ENSP00000161559%0d%0a
Selected Interacting proteins: ENSP00000006724 for CEACAM7 Gene via STRING

Gene Ontology (GO) - Biological Process for CEACAM7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM7 Gene

Drugs & Compounds for CEACAM7 Gene

(6) Drugs for CEACAM7 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gefitinib Approved, Investigational Pharma EGFR Inhibitors, Kinase Inhibitors, Epidermal growth factor receptor (EGFR) inhibitors 322
Levothyroxine Approved Pharma 0
Progesterone Approved Pharma Inhibition, Pore Blocker Endogenous progesterone receptor agonist 473
thymidine Experimental Pharma 0
estrogen Pharma 0

(7) Additional Compounds for CEACAM7 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
5fluorouracil
Actinomycin D
B 723
butyrate
Cycloheximide
genes like me logo Genes that share compounds with CEACAM7: view

Transcripts for CEACAM7 Gene

Unigene Clusters for CEACAM7 Gene

Carcinoembryonic antigen-related cell adhesion molecule 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1:
SP2: -
SP3:
SP4: - -

Relevant External Links for CEACAM7 Gene

GeneLoc Exon Structure for
CEACAM7
ECgene alternative splicing isoforms for
CEACAM7

Expression for CEACAM7 Gene

mRNA expression in normal human tissues for CEACAM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM7 Gene

This gene is overexpressed in Colon - Transverse (x42.4) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for CEACAM7 Gene

This gene is overexpressed in Cervix (20.7), Rectum (19.4), and Urine (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEACAM7 Gene



SOURCE GeneReport for Unigene cluster for CEACAM7 Gene Hs.74466

mRNA Expression by UniProt/SwissProt for CEACAM7 Gene

Q14002-CEAM7_HUMAN
Tissue specificity: Strongly down-regulated in colonic adenocarcinomas
genes like me logo Genes that share expression patterns with CEACAM7: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein tissue co-expression partners for CEACAM7 Gene

Orthologs for CEACAM7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM7 35
  • 98.62 (n)
  • 98.11 (a)
CEACAM7 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 19 (a)
ManyToMany
CEACAM1 36
  • 33 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam10 36
  • 26 (a)
ManyToMany
Species with no ortholog for CEACAM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM7 Gene

ENSEMBL:
Gene Tree for CEACAM7 (if available)
TreeFam:
Gene Tree for CEACAM7 (if available)

Paralogs for CEACAM7 Gene

(24) SIMAP similar genes for CEACAM7 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CEACAM7 Gene

genes like me logo Genes that share paralogs with CEACAM7: view

Variants for CEACAM7 Gene

Sequence variations from dbSNP and Humsavar for CEACAM7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1001062 -- 41,685,546(+) CCTTC(A/C)TTCAT intron-variant
rs1049238 -- 41,674,361(-) gcagg(C/G/T)aattt utr-variant-3-prime
rs1860329 -- 41,684,459(+) CCAAG(A/G)GGTGT intron-variant
rs3786868 -- 41,686,065(-) CTACA(C/G)AGGGC intron-variant
rs3826894 -- 41,686,029(-) TTAAG(A/G)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM7 Gene

Variant ID Type Subtype PubMed ID
esv2718577 CNV Deletion 23290073
nsv522854 CNV Gain 19592680
esv29931 CNV Gain 19812545
nsv442464 CNV CNV 18776908

Variation tolerance for CEACAM7 Gene

Residual Variation Intolerance Score: 83.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM7 Gene

HapMap Linkage Disequilibrium report
CEACAM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM7 Gene

Disorders for CEACAM7 Gene

MalaCards: The human disease database

(10) MalaCards diseases for CEACAM7 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
colon carcinoma in situ
  • stage 0 colonic carcinoma
paget disease, extramammary
  • empd
goblet cell carcinoid
  • goblet cell carcinoma
cervical adenocarcinoma
  • adenocarcinoma of the uterine cervix
bronchus carcinoma
  • bc - bronchogenic carcinoma
- elite association

Relevant External Links for CEACAM7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM7
genes like me logo Genes that share disorders with CEACAM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM7 Gene

Publications for CEACAM7 Gene

  1. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. (PMID: 9135022) Thompson J. … Zimmermann W. (Cancer Res. 1997) 2 23 67
  2. CGM2, a member of the carcinoembryonic antigen gene family is down- regulated in colorectal carcinomas. (PMID: 7806520) Thompson J. … Willcocks T. (J. Biol. Chem. 1994) 2 23 67
  3. Diagnostic value of Her-2/neu, Cyfra 21-1, and carcinoembryonic antigen levels in malignant pleural effusions of lung adenocarcinoma. (PMID: 20350214) Huang W.W. … Tseng C.E. (Pathology 2010) 23 67
  4. Combined evaluation of preoperative FDG uptake on PET, ground-glass opacity area on CT, and serum CEA level: identification of both low and high risk of recurrence in patients with resected T1 lung adenocarcinoma. (PMID: 18931837) Higashi K. … Tonami H. (Eur. J. Nucl. Med. Mol. Imaging 2009) 23 67
  5. p16 INK4 and CEA can be mutually exchanged with confidence between both relevant three-marker panels (ER/Vim/CEA and ER/Vim/p16 INK4) in distinguishing primary endometrial adenocarcinomas from endocervical adenocarcinomas in a tissue microarray study. (PMID: 19763614) Han C.P. … Tseng S.W. (Virchows Arch. 2009) 23 67

Products for CEACAM7 Gene

Sources for CEACAM7 Gene

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