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CEACAM7 Gene

protein-coding   GIFtS: 53
GCID: GC19M042178

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...


(Previous symbol: CGM2)
  See CEACAM7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 71 2
CGM21 2 3
Carcinoembryonic Antigen Gene Family Member 21 2
Carcinoembryonic Antigen CGM22 3
CEA2

External Ids:    HGNC: 18191   Entrez Gene: 10872   Ensembl: ENSG000000073067   UniProtKB: Q140023   

Export aliases for CEACAM7 gene to outside databases

Previous GC identifers: GC19M042816 GC19M042568 GC19M046853 GC19M046869 GC19M038609


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CEACAM7 Gene:
CEACAM7 (carcinoembryonic antigen-related cell adhesion molecule 7) is a protein-coding gene. Diseases associated with CEACAM7 include goblet cell carcinoid, and secretory meningioma. An important paralog of this gene is PSG9.

Gene Wiki entry for CEACAM7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  NT_187620.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEACAM7 gene promoter:
         AP-1   NRSF form 1   NF-kappaB1   NF-kappaB   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM7 promoter sequence
   Search Chromatin IP Primers for CEACAM7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEACAM7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CEACAM7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M042178:  view genomic region     (about GC identifiers)

Start:
42,177,235 bp from pter      End:
42,210,895 bp from pter
Size:
33,661 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 7 precursor  
Size: 265 amino acids; 29379 Da
Secondary accessions: A8K848 O15148 O15149 Q0VAC1 Q13983 Q9UPJ2
Alternative splicing: 2 isoforms:  Q14002-1   Q14002-2   

Explore the universe of human proteins at neXtProt for CEACAM7: NX_Q14002

Explore proteomics data for CEACAM7 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Asn85, Asn105, Asn112, Asn174, Asn183, Asn198
  • Modification sites at PhosphoSitePlus

  • See CEACAM7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_008821.1  
    ENSEMBL proteins: 
     ENSP00000006724   ENSP00000385932   ENSP00000469597   ENSP00000343286  

    CEACAM7 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for CEACAM7

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q14002

    ProtoNet protein and cluster: Q14002

    2 Blocks protein domains:
    IPB003599 Immunoglobulin subtype
    IPB013098 Immunoglobulin I-set


    UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    Find genes that share domains with CEACAM7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for CEACAM7:
    carcinoembryonic antigen-related cell adhesion molecule 7 (see CEA@)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    Find genes that share ontologies with CEACAM7           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CEACAM7:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEACAM7
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEAM7_HUMAN, Q14002: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    mitochondrion2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IEA--
    GO:0016021integral component of membrane TAS7806520
    GO:0031225anchored component of membrane IEA--

    Find genes that share ontologies with CEACAM7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEACAM7
    Interactions:

        Search GeneGlobe Interaction Network for CEACAM7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    2 Interacting proteins for CEACAM7 (ENSP000000067244) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEACAM1ENSP000001615594STRING: ENSP00000161559
    CEACAM6ENSP000001997644STRING: ENSP00000199764
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEACAM7 (CEAM7)

    Selected Novoseek inferred chemical compound relationships for CEACAM7 gene (see all 13)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 723 64.1 5 7779533 (1), 1569446 (1), 1716293 (1), 12647218 (1) (see all 5)
    mucicarmine 51.3 1 9208972 (1)
    gefitinib 28.1 8 15738541 (2), 16824645 (2), 17941001 (1)
    5fluorouracil 3.88 3 12743424 (2)
    butyrate 2.17 4 9056678 (1), 11535873 (1)
    thymidine 0 1 7923150 (1)
    progesterone 0 2 12493029 (1), 11444201 (1)
    triiodothyronine 0 1 1851587 (1)
    estrogen 0 7 11444201 (1), 19763614 (1), 12647218 (1), 11781517 (1) (see all 5)
    thyroxine 0 1 1851587 (1)



    Find genes that share compounds with CEACAM7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CEACAM7 gene: 
    NM_006890.3  

    Unigene Cluster for CEACAM7:

    Carcinoembryonic antigen-related cell adhesion molecule 7
    Hs.74466  [show with all ESTs]
    Unigene Representative Sequence: X98311
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000006724(uc002ori.1 uc010ehx.2) ENST00000401731 ENST00000602225
    ENST00000599715 ENST00000338196(uc010ehy.1)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CEACAM7

    Additional mRNA sequence: 

    AF006622.1 AF006623.1 AK292213.1 AK296634.1 AK311285.1 AK313108.1 BC121132.2 L31792.1 
    X98311.1 

    6 DOTS entries:

    DT.40115478  DT.121504120  DT.92039756  DT.310603  DT.121504116  DT.121504119 

    Selected AceView cDNA sequences (see all 49):

    AI695136 AW780407 AW780234 AA577615 AU076440 AI304573 AI707997 AI281195 
    NM_006890 AF006622 BX480010 X98311 BX479917 T29474 AI720037 AL602909 
    L31792 AA527591 AW951207 BV167322 BX505824 AW468781 BX480021 AA327251 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM7    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                                                        
    SP2:                                                        -               
    SP3:                                                                        
    SP4:                                -     -                                 


    ECgene alternative splicing isoforms for CEACAM7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEACAM7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEACAM7 Expression
    About this image

    CEACAM7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEACAM7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.74466

    UniProtKB/Swiss-Prot: CEAM7_HUMAN, Q14002
    Tissue specificity: Strongly down-regulated in colonic adenocarcinomas

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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      --

    ENSEMBL Gene Tree for CEACAM7 (if available)
    TreeFam Gene Tree for CEACAM7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEACAM7 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM212  PSG12  
    PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    Selected SIMAP similar genes for CEACAM7 using alignment to 1 protein entry:     CEAM7_HUMAN(see all similar genes):
    CEACAM1    CEA    CEACAM5    CEACAM6    CEACAM3    CEACAM8
    CEACAM4    PSG6    PSG1    DHFRP2    PSG    PSG7
    SP1    PSG11    PSG2    PSG3    PSG4    PSG5

    Find genes that share paralogs with CEACAM7           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CEACAM7
    PGOHUM00000259339 PGOHUM00000250580


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEACAM7 (see all 411)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1908465761,2
    C--42176910(+) ATTTTC/TGTTGT 1 -- ds50010--------
    rs1826984151,2
    --42177050(+) AGTTAA/GGTTTC 1 -- ds50010--------
    rs1462316891,2
    --42177134(+) AGAGGA/CGGAAG 1 -- ds50010--------
    rs1392054581,2
    --42177157(+) AATGAG/TGCAGC 1 -- ds50010--------
    rs1149212971,2
    --42177185(+) CCATCA/GCTGGC 1 -- ds50010--------
    rs755846711,2
    C--42177410(+) ATTTCA/GGAATA 1 -- ut310--------
    rs1449410591,2
    --42177927(+) CCACAA/TGAGAA 1 -- ut310--------
    rs2002354361,2
    C--42177934(+) AGAAG-/CCTACC 1 -- ut310--------
    rs1486199911,2
    --42177952(+) ATCAAA/GCAGCA 1 -- ut310--------
    rs1420488011,2
    --42177999(+) CCACTA/GTATTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for CEACAM7 (42177235 - 42210895 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CEACAM7:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718577CNV Deletion23290073
    nsv522854CNV Gain19592680
    esv29931CNV Gain19812545
    nsv442464CNV CNV18776908

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    10 diseases for CEACAM7:    
    About MalaCards
    goblet cell carcinoid    secretory meningioma    colorectal adenocarcinoma    mucoepidermoid carcinoma
    mucinous cystadenocarcinoma    pseudomyxoma peritonei    lung adenocarcinoma    adenocarcinoma
    colon cancer    lung cancer


    Find genes that share disorders with CEACAM7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CEACAM7 gene (see all 63)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 83.4 131 11781517 (4), 10467024 (3), 1700970 (3), 19686409 (3) (see all 82)
    colon adenocarcinoma 70.5 12 9237098 (1), 10688120 (1), 7806520 (1), 8205554 (1) (see all 10)
    cervical adenocarcinoma 69.4 11 2258083 (2), 12647218 (2), 2153042 (2), 15297173 (2) (see all 7)
    colon tumor 66.8 8 12743424 (2), 9056678 (2), 20354120 (1), 1998972 (1)
    adenocarcinoma lung 62.1 13 7789485 (6), 17219955 (2), 18931837 (2), 17941001 (1)
    colorectal carcinoma 62.1 36 8374868 (4), 15332370 (4), 2092570 (3), 9589054 (2) (see all 15)
    colorectal cancer 61.7 33 11712806 (2), 2166552 (2), 18780338 (2), 1643605 (2) (see all 20)
    colon carcinoma 60.6 8 10472328 (2), 8453631 (1), 8317550 (1), 8168994 (1) (see all 6)
    colon cancer 59.1 14 10472328 (2), 10864342 (2), 1851587 (2), 2334536 (1) (see all 10)
    tumors 58.6 192 8265235 (6), 8683233 (6), 10472328 (5), 16425302 (5) (see all 84)


    Export disorders for CEACAM7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEACAM7 gene, integrated from 10 sources (see all 221):
    (articles sorted by number of sources associating them with CEACAM7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. CGM2, a member of the carcinoembryonic antigen gene family is down- regulated in colorectal carcinomas. (PubMed id 7806520)1, 2, 3, 9 Thompson J.... Willcocks T. (J. Biol. Chem. 1994)
    2. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. (PubMed id 9135022)1, 2, 3, 9 Thompson J....Zimmermann W. (Cancer Res. 1997)
    3. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PubMed id 1427854)1, 2, 9 Khan W.N....Hammarstroem S. (Genomics 1992)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)1, 2 Grimwood J.... Lucas S.M. (Nature 2004)
    5. Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)1, 2 Zhang Z. and Henzel W.J. (Protein Sci. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Analysis of the size of the carcinoembryonic antigen (CEA) gene family: isolation and sequencing of N-terminal domain exons. (PubMed id 2537643)1, 2 Thompson J.A.... Zimmermann W. (Biochem. Biophys. Res. Commun. 1989)
    8. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. (PubMed id 10666389)1, 9 SchAPlzel S....Thompson J. (Am. J. Pathol. 2000)
    9. Four carcinoembryonic antigen subfamily members, CEA, NCA, BGP and CGM2, selectively expressed in the normal human colonic epithelium, are integral components of the fuzzy coat. (PubMed id 10436421)1, 9 FrAongsmyr L....HammarstrAPm S. (Tumour Biol. 1999)
    10. Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas. (PubMed id 9533775)1, 9 Kinugasa T....Matsuoka Y. (Int. J. Cancer 1998)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1087 HGNC: 1819 AceView: CEACAM7 Ensembl:ENSG00000007306 euGenes: HUgn1087
    ECgene: CEACAM7 H-InvDB: CEACAM7

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEACAM7 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEACAM7 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
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    Patent Information for CEACAM7 gene:
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