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Aliases for CEACAM7 Gene

Aliases for CEACAM7 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 7 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 2 3
  • Carcinoembryonic Antigen Gene Family Member 2 2 3
  • Carcinoembryonic Antigen CGM2 3 4
  • CGM2 3 4

External Ids for CEACAM7 Gene

Previous HGNC Symbols for CEACAM7 Gene

  • CGM2

Previous GeneCards Identifiers for CEACAM7 Gene

  • GC19M042816
  • GC19M042568
  • GC19M046853
  • GC19M046869
  • GC19M042178
  • GC19M038609

Summaries for CEACAM7 Gene

Entrez Gene Summary for CEACAM7 Gene

  • This gene encodes a cell surface glycoprotein and member of the carcinoembryonic antigen (CEA) family of proteins. Expression of this gene may be downregulated in colon and rectal cancer. Additionally, lower expression levels of this gene may be predictive of rectal cancer recurrence. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]

GeneCards Summary for CEACAM7 Gene

CEACAM7 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 7) is a Protein Coding gene. Diseases associated with CEACAM7 include Colorectal Cancer and Gastric Adenocarcinoma. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins. An important paralog of this gene is CEACAM5.

Gene Wiki entry for CEACAM7 Gene

Additional gene information for CEACAM7 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM7 Gene

Genomics for CEACAM7 Gene

Regulatory Elements for CEACAM7 Gene

Enhancers for CEACAM7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H041732 1.2 FANTOM5 ENCODE dbSUPER 22.7 -27.8 -27808 4 SMARCE1 PKNOX1 RNF2 KLF4 FOXA1 E2F1 CTBP1 CBX8 ZNF547 BCL6B CEACAM7 CEACAM5 DMRTC2 LYPD4 CEACAM6 ENSG00000267881
GH19H041637 1.1 FANTOM5 Ensembl ENCODE 15.9 +68.4 68355 2 SREBF1 CTCF POLR2A PRDM10 REST CEACAM7 CEACAM5 CEACAM6 DMAC2 BCKDHA EXOSC5 ENSG00000268582 ARHGEF1 B9D2 CEACAM4
GH19H041744 1.1 Ensembl ENCODE dbSUPER 10.9 -38.5 -38501 2 CTCF MAZ ZNF654 REST RAD21 SMC3 ZNF350 ZNF143 HMBOX1 PRDM10 CEACAM5 SNRPA HNRNPUL1 CEACAM7 ZNF526 CEACAM4 ZNF574 ENSG00000269843 CCDC97 CEACAM6
GH19H041772 1 ENCODE dbSUPER 10.8 -67.3 -67340 4 PKNOX1 ESRRA CTBP1 GATA3 FOSL2 FOS RCOR1 TCF7L2 SMARCE1 MNT HNRNPUL1 ZNF526 CCDC97 CIC ENSG00000269843 CEACAM5 CEACAM7 ERF RPS19 HNRNPA1P52
GH19H041776 0.9 ENCODE dbSUPER 10.8 -69.9 -69932 0 SMARCE1 ELF1 DPF2 FOXA1 ZNF217 GATA3 CTBP1 CREB1 RCOR1 CEACAM5 CEACAM7 LYPD4 ENSG00000268833 CEACAM6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM7 Gene

Chromosome:
19
Start:
41,673,307 bp from pter
End:
41,706,976 bp from pter
Size:
33,670 bases
Orientation:
Minus strand

Genomic View for CEACAM7 Gene

Genes around CEACAM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM7 Gene

Proteins for CEACAM7 Gene

  • Protein details for CEACAM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14002-CEAM7_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 7
    Protein Accession:
    Q14002
    Secondary Accessions:
    • A8K848
    • O15148
    • O15149
    • Q0VAC1
    • Q13983
    • Q9UPJ2

    Protein attributes for CEACAM7 Gene

    Size:
    265 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for CEACAM7 Gene

    Alternative splice isoforms for CEACAM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM7 Gene

Post-translational modifications for CEACAM7 Gene

  • Glycosylation at Asn57, posLast=8585, posLast=105105, posLast=112112, Asn174, posLast=183183, and posLast=198198
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM7 Gene

Antibody Products

  • Abcam antibodies for CEACAM7

No data available for DME Specific Peptides for CEACAM7 Gene

Domains & Families for CEACAM7 Gene

Protein Domains for CEACAM7 Gene

Suggested Antigen Peptide Sequences for CEACAM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14002

UniProtKB/Swiss-Prot:

CEAM7_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM7: view

Function for CEACAM7 Gene

Molecular function for CEACAM7 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 7 (see CEA@)
genes like me logo Genes that share phenotypes with CEACAM7: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEACAM7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM7 Gene

Localization for CEACAM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM7 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM7 gene
Compartment Confidence
plasma membrane 5
extracellular 5
mitochondrion 2
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 7806520
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM7: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CEACAM7 Gene

Pathways & Interactions for CEACAM7 Gene

genes like me logo Genes that share pathways with CEACAM7: view

Gene Ontology (GO) - Biological Process for CEACAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006501 C-terminal protein lipidation TAS --
genes like me logo Genes that share ontologies with CEACAM7: view

No data available for SIGNOR curated interactions for CEACAM7 Gene

Drugs & Compounds for CEACAM7 Gene

(7) Drugs for CEACAM7 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for CEACAM7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM7: view

Transcripts for CEACAM7 Gene

Unigene Clusters for CEACAM7 Gene

Carcinoembryonic antigen-related cell adhesion molecule 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CEACAM7
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1:
SP2: -
SP3:
SP4: - -

Relevant External Links for CEACAM7 Gene

GeneLoc Exon Structure for
CEACAM7
ECgene alternative splicing isoforms for
CEACAM7

Expression for CEACAM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM7 Gene

This gene is overexpressed in Colon - Transverse (x42.4) and Esophagus - Mucosa (x4.4).

Protein differential expression in normal tissues from HIPED for CEACAM7 Gene

This gene is overexpressed in Cervix (20.7), Rectum (19.4), and Urine (18.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CEACAM7 Gene



NURSA nuclear receptor signaling pathways regulating expression of CEACAM7 Gene:

CEACAM7

SOURCE GeneReport for Unigene cluster for CEACAM7 Gene:

Hs.74466

mRNA Expression by UniProt/SwissProt for CEACAM7 Gene:

Q14002-CEAM7_HUMAN
Tissue specificity: Strongly down-regulated in colonic adenocarcinomas.

Evidence on tissue expression from TISSUES for CEACAM7 Gene

  • Intestine(4.9)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with CEACAM7: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM7 Gene

Orthologs for CEACAM7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM7 33 34
  • 98.62 (n)
cow
(Bos Taurus)
Mammalia CEACAM1 34
  • 33 (a)
ManyToMany
-- 34
  • 19 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam10 34
  • 26 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 22 (a)
ManyToMany
Species where no ortholog for CEACAM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM7 Gene

ENSEMBL:
Gene Tree for CEACAM7 (if available)
TreeFam:
Gene Tree for CEACAM7 (if available)

Paralogs for CEACAM7 Gene

(24) SIMAP similar genes for CEACAM7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CEACAM7: view

Variants for CEACAM7 Gene

Sequence variations from dbSNP and Humsavar for CEACAM7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000248838 -- 41,686,221(+) CTCTT(A/G)AGTTC intron-variant
rs1000303782 -- 41,679,458(+) CCAAC(A/G)CTAAC intron-variant
rs1000525458 -- 41,678,287(+) GGACT(A/T)TTTGT intron-variant
rs1000582906 -- 41,684,832(+) TGTGC(A/G)GTCAG intron-variant
rs1000592013 -- 41,679,799(+) TCTCT(C/T)TCTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM7 Gene

Variant ID Type Subtype PubMed ID
esv2718577 CNV deletion 23290073
esv29931 CNV gain 19812545
esv3644390 CNV loss 21293372
esv3644391 CNV gain 21293372
nsv1061309 CNV gain 25217958
nsv442464 CNV gain 18776908
nsv522854 CNV gain 19592680
nsv960841 CNV duplication 23825009

Variation tolerance for CEACAM7 Gene

Residual Variation Intolerance Score: 83.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.35; 53.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM7 Gene

Disorders for CEACAM7 Gene

MalaCards: The human disease database

(7) MalaCards diseases for CEACAM7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
gastric adenocarcinoma
  • adenocarcinoma of stomach
goblet cell carcinoid
  • gcc
stomach cancer
  • gastric cancer
colon carcinoma in situ
  • carcinoma in situ of colon
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CEACAM7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM7
genes like me logo Genes that share disorders with CEACAM7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM7 Gene

Publications for CEACAM7 Gene

  1. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. (PMID: 9135022) Thompson J … Zimmermann W (Cancer research 1997) 2 3 4 22 60
  2. CGM2, a member of the carcinoembryonic antigen gene family is down-regulated in colorectal carcinomas. (PMID: 7806520) Thompson J … Willcocks T (The Journal of biological chemistry 1994) 2 3 4 22 60
  3. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PMID: 1427854) Khan WN … Hammarström S (Genomics 1992) 3 4 22 60
  4. Structure of the N-terminal dimerization domain of CEACAM7. (PMID: 26323304) Bonsor DA … Sundberg EJ (Acta crystallographica. Section F, Structural biology communications 2015) 3 4 60
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 60

Products for CEACAM7 Gene

Sources for CEACAM7 Gene

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