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Aliases for CEACAM7 Gene

Aliases for CEACAM7 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 2 3
  • Carcinoembryonic Antigen Gene Family Member 2 2 3
  • Carcinoembryonic Antigen CGM2 3 4
  • CGM2 3 4
  • CEA 3

External Ids for CEACAM7 Gene

Previous HGNC Symbols for CEACAM7 Gene

  • CGM2

Previous GeneCards Identifiers for CEACAM7 Gene

  • GC19M042816
  • GC19M042568
  • GC19M046853
  • GC19M046869
  • GC19M042178
  • GC19M038609

Summaries for CEACAM7 Gene

GeneCards Summary for CEACAM7 Gene

CEACAM7 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7) is a Protein Coding gene. Diseases associated with CEACAM7 include goblet cell carcinoid and colorectal adenocarcinoma. An important paralog of this gene is CEACAM8.

Gene Wiki entry for CEACAM7 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM7 Gene

Genomics for CEACAM7 Gene

Regulatory Elements for CEACAM7 Gene

Genomic Location for CEACAM7 Gene

41,673,307 bp from pter
41,706,976 bp from pter
33,670 bases
Minus strand

Genomic View for CEACAM7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM7 Gene

Proteins for CEACAM7 Gene

  • Protein details for CEACAM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 7
    Protein Accession:
    Secondary Accessions:
    • A8K848
    • O15148
    • O15149
    • Q0VAC1
    • Q13983
    • Q9UPJ2

    Protein attributes for CEACAM7 Gene

    265 amino acids
    Molecular mass:
    29379 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CEACAM7 Gene


neXtProt entry for CEACAM7 Gene

Proteomics data for CEACAM7 Gene at MOPED

Post-translational modifications for CEACAM7 Gene

  • Glycosylation at Asn57, Asn85, Asn105, Asn112, Asn174, Asn183, and Asn198
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM7 Gene

Antibody Products

No data available for DME Specific Peptides for CEACAM7 Gene

Domains for CEACAM7 Gene

Gene Families for CEACAM7 Gene

  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CEACAM7 Gene

Suggested Antigen Peptide Sequences for CEACAM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q14002
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM7: view

Function for CEACAM7 Gene

Molecular function for CEACAM7 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 7 (see CEA@)

Gene Ontology (GO) - Molecular Function for CEACAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CEACAM7: view

Phenotypes for CEACAM7 Gene

genes like me logo Genes that share phenotypes with CEACAM7: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CEACAM7 Gene

Localization for CEACAM7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM7 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

Jensen Localization Image for CEACAM7 Gene COMPARTMENTS Subcellular localization image for CEACAM7 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane TAS 7806520
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM7: view

Pathways for CEACAM7 Gene

SuperPathways for CEACAM7 Gene

No Data Available

Interacting Proteins for CEACAM7 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000006724 for CEACAM7 Gene via STRING

Gene Ontology (GO) - Biological Process for CEACAM7 Gene


No data available for Pathways by source for CEACAM7 Gene

Compounds for CEACAM7 Gene

(13) Novoseek inferred chemical compound relationships for CEACAM7 Gene

Compound -log(P) Hits PubMed IDs
b 723 64.1 5
mucicarmine 51.3 1
gefitinib 28.1 5
5fluorouracil 3.88 2
butyrate 2.17 2
genes like me logo Genes that share compounds with CEACAM7: view

Transcripts for CEACAM7 Gene

Unigene Clusters for CEACAM7 Gene

Carcinoembryonic antigen-related cell adhesion molecule 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM7

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM7 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP2: -
SP4: - -

Relevant External Links for CEACAM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEACAM7 Gene

mRNA expression in normal human tissues for CEACAM7 Gene

mRNA differential expression in normal tissues according to GTEx for CEACAM7 Gene

This gene is overexpressed in Colon - Transverse (42.4) and Esophagus - Mucosa (4.4).

Protein differential expression in normal tissues for CEACAM7 Gene

This gene is overexpressed in Cervix (20.7), Rectum (19.4), and Urine (18.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CEACAM7 Gene

SOURCE GeneReport for Unigene cluster for CEACAM7 Gene Hs.74466

mRNA Expression by UniProt/SwissProt for CEACAM7 Gene

Tissue specificity: Strongly down-regulated in colonic adenocarcinomas
genes like me logo Genes that share expressions with CEACAM7: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Expression partners for CEACAM7 Gene

Orthologs for CEACAM7 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CEACAM7 35
  • 98.62 (n)
  • 98.11 (a)
  • 98 (a)
(Bos Taurus)
Mammalia -- 36
  • 19 (a)
  • 33 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
(Mus musculus)
Mammalia Ceacam10 36
  • 26 (a)
Species with no ortholog for CEACAM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM7 Gene

Gene Tree for CEACAM7 (if available)
Gene Tree for CEACAM7 (if available)

Paralogs for CEACAM7 Gene

Selected SIMAP similar genes for CEACAM7 Gene using alignment to 1 proteins: Pseudogenes for CEACAM7 Gene

genes like me logo Genes that share paralogs with CEACAM7: view

Variants for CEACAM7 Gene

Sequence variations from dbSNP and Humsavar for CEACAM7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1000971 -- 41,676,018(-) ATTTG(G/T)TAATG intron-variant
rs1001062 -- 41,685,546(+) CCTTC(A/C)TTCAT intron-variant
rs1008577 -- 41,683,363(+) ATATA(A/T)CTGGG intron-variant
rs1049234 -- 41,687,075(-) AAGGG(C/G)AAAGG missense, reference
rs1049236 -- 41,686,947(-) AACGT(C/T)ACCCA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CEACAM7 Gene

Variant ID Type Subtype PubMed ID
esv2718577 CNV Deletion 23290073
nsv522854 CNV Gain 19592680
esv29931 CNV Gain 19812545
nsv442464 CNV CNV 18776908

Relevant External Links for CEACAM7 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM7 Gene

Disorders for CEACAM7 Gene

(63) Novoseek inferred disease relationships for CEACAM7 Gene

Disease -log(P) Hits PubMed IDs
adenocarcinoma 83.4 115
colon adenocarcinoma 70.5 10
cervical adenocarcinoma 69.4 11
colon tumor 66.8 6
adenocarcinoma lung 62.1 11
genes like me logo Genes that share disorders with CEACAM7: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Genatlas and External Links for CEACAM7 Gene

Publications for CEACAM7 Gene

  1. CGM2, a member of the carcinoembryonic antigen gene family is down- regulated in colorectal carcinomas. (PMID: 7806520) Thompson J. … Willcocks T. (J. Biol. Chem. 1994) 2 3 4 23
  2. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. (PMID: 9135022) Thompson J. … Zimmermann W. (Cancer Res. 1997) 2 3 4 23
  3. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PMID: 1427854) Khan W.N. … Hammarstroem S. (Genomics 1992) 3 4 23
  4. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. (PMID: 10666389) SchAPlzel S. … Thompson J. (Am. J. Pathol. 2000) 3 23
  5. Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas. (PMID: 9533775) Kinugasa T. … Matsuoka Y. (Int. J. Cancer 1998) 3 23

Products for CEACAM7 Gene

Sources for CEACAM7 Gene

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