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Aliases & Descriptions for CEACAM6
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CD66c 1, 2 | | CEAL 2 | | NCA 2, 3, 5 |
| | | Descriptions |
|---|
| CD66c antigen 3 | | Non-specific crossreacting antigen 3 | | Normal cross-reacting antigen 3 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 2 |
|
| | Search outside databases for aliases for CEACAM6 genePrevious GC identifers: GC19P042899 GC19P042652 GC19P046935 GC19P046952 GC19P046953 |
Summaries for CEACAM6(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CEACAM6: Carcinoembryonic antigen (CEA; MIM 114890) is one of the most widely used tumor markers in serum immunoassay determinations of carcinoma. An apparent lack of absolute cancer specificity for CEA probably results in part from the presence in normal and neoplastic tissues of antigens that share antigenic determinants with the 180-kD form of CEA (Barnett et al., 1988 [PubMed 3220478]). For background information on the CEA family of genes, see CEACAM1 (MIM 109770).[supplied by OMIM] Gene Wiki entry for CEACAM6 |
Genomic Location for CEACAM6
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CEACAM6 gene 
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1-q13.2CEACAM6 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P046954:
(about GC identifiers)
Start:
|
46,951,341 bp from pter |
End:
|
46,967,953 bp from pter |
Size:
|
16,613 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for CEACAM6
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CEAM6_HUMAN, P40199 (See
protein sequence)Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 6 precursor Size: 344 amino acids; 37237 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Secondary accessions: Q13774 Q14920Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_002474.3
ENSEMBL proteins: ENSP00000199764
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CEACAM6: Assays for CEACAM6: | Protein
Domains/ Families for CEACAM6(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P40199
ProtoNet protein and cluster: P40199 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: CEAM6_HUMAN, P40199Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for CEACAM6
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002483
Applied Biosystems Silencer® siRNAs for CEACAM6
Sigma-Aldrich siRNA for CEACAM6  Sigma-Aldrich shRNA for CEACAM6  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002483                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002483                                  untagged cDNA clone in CMV expression vector: NM_002483 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002483
Genatlas biochemistry entry for CEACAM6:carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) see CEA@ | Pathways & Interactions for CEACAM6
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for CEACAM6 
3 Interacting proteins for CEACAM6 (ENSP000001997643) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for CEACAM6(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CEACAM6 2 Novoseek chemical compound relationships for CEACAM6 gene
About this table
|
Transcripts for CEACAM6(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002483
Sigma-Aldrich siRNA for CEACAM6  Sigma-Aldrich shRNA for CEACAM6  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002483 REFSEQ mRNAs for CEACAM6 gene: NM_002483.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002483               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002483                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002483                                  untagged cDNA clone in CMV expression vector: NM_002483  Additional cDNA sequence: AK312542.1 BC005008.1 BT009774.1 M18216.1 M18728.1 M29541.1 13 DOTS entries: DT.75132501 DT.95283649 DT.97775351 DT.121426879 DT.100817400 DT.92439255 DT.100035515 DT.92439263 DT.95091257 DT.91781710 DT.91785493 DT.95093356 DT.95286776 24/382 AceView cDNA sequences (see all 382
):AI677998 AI569894 AA581264 AI582988 AW849353 AI920992 AW849702 AI911695 AA367446 AI955696 BF221579 AI473526 BE049599 CB851726 BM981598 AA939328 BM751023 AW243579 BM976048 AW849659 AW198029 AI813978 AI587485 AA828073
highest scoring ESTs for CEACAM6:AI587104 AI694729 AI963511 AW007623 BE615827 BF093570 BF093575 BG546290 BM741054 BM745537 Unigene Cluster for CEACAM6: Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) Hs.466814 [show with all ESTs]Unigene Representative Sequence: NM_002483
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000199764
|
Expression for CEACAM6
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CEACAM6 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CEACAM6
1 / 2 / 3 5 probe-sets matching CEACAM6 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AAGGATAAAA
SOURCE GeneReport for Unigene cluster: Hs.466814
Expression variation in blood from EXPOLDB for CEACAM6 |
Orthologs for CEACAM6
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CEACAM6 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
zebrafish (Danio rerio) |
ceacam11 |
-- |
carcinoembryonic antigen-related cell adhesion molecule more |
46.79(n) 37.61(a) |
114465 NM_001113794.1 NP_001107266.1 |
About this table Species with no ortholog for CEACAM6
ENSEMBL Gene Tree for CEACAM6 | Paralogs for CEACAM6(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CEACAM6 gene
- CEACAM11 2 CEACAM51 2 PSG52 PSG92 PSG82 PSG62 PSG112 CEACAM82
- PSG32 CEACAM72 PSG22 PSG72 PSG12
|
SNPs/Variants for CEACAM6(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CEACAM6 (up to first 250kb)
|
Disorders & Mutations for CEACAM6
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 163980
10/28 Novoseek disease relationships for CEACAM6 gene (see all 28
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| colon carcinoma |
66.17 |
9 |
2067130 (2), 1815506 (1), 9028835 (1), 11896570 (1) (see all 7) |
| gastrointestinal carcinoma |
61.51 |
1 |
8188529 (1) |
| colorectal carcinoma |
55.78 |
6 |
9041239 (1), 9654079 (1), 9250164 (1), 18159236 (1) (see all 5) |
| adenocarcinoma |
49.94 |
24 |
15729073 (5), 15208677 (4), 14724575 (3), 15316565 (3) (see all 9) |
| colon cancer |
39.83 |
5 |
9085168 (2), 9028835 (1), 16204051 (1) |
| carcinoma |
39.28 |
16 |
2125040 (4), 9533775 (3), 2067130 (2), 9250164 (1) (see all 6) |
| colorectal tumors |
39.10 |
2 |
10666389 (1), 14512395 (1) |
| cholangiocarcinoma |
38.26 |
8 |
16868542 (5), 19055478 (1), 2187320 (1) |
| gastric carcinoma |
37.34 |
1 |
8504201 (1) |
| adenoma |
36.27 |
14 |
2125040 (3), 2067130 (2), 10666389 (2), 9192807 (2) (see all 6) |
About this table
1 PharmGKB disease relationship for CEACAM6 geneAbout this table
Human Genome Epidemiology Navigator: CEACAM6 (1 document)
|
Medical News for CEACAM6(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CEACAM6 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/148 PubMed articles for CEACAM6 gene (see all 148
):- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)3, 4 Ramachandran P....Loo J.A. (2006)
- Signal peptide prediction based on analysis of experimentally verified cleavage sites. (PubMed id 15340161)3, 4 Zhang Z. and Henzel W.J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. (PubMed id 3220478)3, 4 Barnett T.... Elting J.J. (1988)
- Characterization of a cDNA clone for the nonspecific cross-reacting antigen (NCA) and a comparison of NCA and carcinoembryonic antigen. (PubMed id 2830274)3, 4 Neumaier M....Shively J.E. (1988)
- Primary structure of nonspecific crossreacting antigen (NCA), a member of carcinoembryonic antigen (CEA) gene family, deduced from cDNA sequence. (PubMed id 3337731)3, 4 Tawaragi Y.... Nakazato H. (1988)
- Expression patterns of CEACAM5 and CEACAM6 in primary and metastatic cancers. (PubMed id 17201906)1, 3 Blumenthal R.D....Goldenberg D.M. (2007)
- CEACAM6 is a determinant of pancreatic adenocarcinoma cellular invasiveness. (PubMed id 15316565)1, 3 Duxbury M.S....Whang E.E. (2004)
- Myeloid antigens in childhood lymphoblastic leukemia: clinical data point to regulation of CD66c distinct from other myeloid antigens. (PubMed id 15826304)1, 3 Kalina T....Hrusak O. (2005)
- Overexpression of CEACAM6 promotes insulin-like growth factor I-induced pancreatic adenocarcinoma cellular invasiveness. (PubMed id 15208677)1, 3 Duxbury M.S....Whang E.E. (2004)
|
Search for CEACAM6
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CEACAM6
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CEACAM6
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEACAM6(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for CEACAM6(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CEACAM6:

 | |
 | | | | |
|
 |  |  |
| | Recombinant Proteins (CEACAM 5 + 6, CD66c + CD66e, pan CEACAM, CEACAM6, CD66a + CD66c + CD66d + CD66e, CD66a + CD66c + CD66d) | | Antibodies (CEACAM 5 + 6, CD66c + CD66e, pan CEACAM, CEACAM6, CD66a + CD66c + CD66d + CD66e, CD66a + CD66c + CD66d) |
| | | Search Tocris compounds for CEACAM6 |
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Incremental update: 13 Oct 2009
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