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Aliases for CEACAM6 Gene

Aliases for CEACAM6 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen) 2 3
  • NCA 3 4 6
  • Normal Cross-Reacting Antigen 3 4
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 3
  • Non-Specific Crossreacting Antigen 4
  • Cluster Of Differentiation 66c 3
  • CD66c Antigen 4
  • CD66c 3
  • CEAL 3

External Ids for CEACAM6 Gene

Previous Symbols for CEACAM6 Gene

  • NCA

Summaries for CEACAM6 Gene

Entrez Gene Summary for CEACAM6 Gene

  • This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

GeneCards Summary for CEACAM6 Gene

CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen)) is a Protein Coding gene. Diseases associated with CEACAM6 include cholangiocarcinoma. An important paralog of this gene is CEACAM8.

Gene Wiki entry for CEACAM6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM6 Gene

Genomics for CEACAM6 Gene

Genomic Location for CEACAM6 Gene

Start:
41,750,977 bp from pter
End:
41,772,208 bp from pter
Size:
21,232 bases
Orientation:
Plus strand

Genomic View for CEACAM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM6 Gene

Regulatory Elements for CEACAM6 Gene

Proteins for CEACAM6 Gene

  • Protein details for CEACAM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40199-CEAM6_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 6
    Protein Accession:
    P40199
    Secondary Accessions:
    • Q13774
    • Q14920
    • Q53XP7

    Protein attributes for CEACAM6 Gene

    Size:
    344 amino acids
    Molecular mass:
    37195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CEACAM6 Gene

Proteomics data for CEACAM6 Gene at MOPED

Post-translational modifications for CEACAM6 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn104, Asn111, Asn115, Asn152, Asn173, Asn197, Asn224, Asn256, Asn274, Asn288, Asn292, and Asn309

Other Protein References for CEACAM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEACAM6 Gene

Domains for CEACAM6 Gene

Gene Families for CEACAM6 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CEACAM6 Gene

UniProtKB/Swiss-Prot:

CEAM6_HUMAN
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.:
    • P40199
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P40199
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.:
    • P40199
genes like me logo Genes that share domains with CEACAM6: view

Function for CEACAM6 Gene

Molecular function for CEACAM6 Gene

GENATLAS Biochemistry: carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) see CEA@

Gene Ontology (GO) - Molecular Function for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CEACAM6: view

Phenotypes for CEACAM6 Gene

genes like me logo Genes that share phenotypes with CEACAM6: view

miRNA for CEACAM6 Gene

miRTarBase miRNAs that target CEACAM6

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEACAM6 Gene

Localization for CEACAM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM6 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM6 Gene COMPARTMENTS Subcellular localization image for CEACAM6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3220478
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM6: view

Pathways for CEACAM6 Gene

SuperPathways for CEACAM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 3220478
GO:0007267 cell-cell signaling TAS 3220478
GO:0007596 blood coagulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CEACAM6: view

No data available for Pathways by source for CEACAM6 Gene

Compounds for CEACAM6 Gene

(4) Novoseek inferred chemical compound relationships for CEACAM6 Gene

Compound -log(P) Hits PubMed IDs
gemcitabine 11.2 5
phosphatidylinositol 7.82 2
calcium 0 1
paraffin 0 3
genes like me logo Genes that share compounds with CEACAM6: view

Transcripts for CEACAM6 Gene

mRNA/cDNA for CEACAM6 Gene

Unigene Clusters for CEACAM6 Gene

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM6 Gene

No ASD Table

Relevant External Links for CEACAM6 Gene

GeneLoc Exon Structure for
CEACAM6
ECgene alternative splicing isoforms for
CEACAM6

Expression for CEACAM6 Gene

mRNA expression in normal human tissues for CEACAM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM6 Gene

This gene is overexpressed in Esophagus - Mucosa (13.2), Minor Salivary Gland (11.8), Lung (10.1), Colon - Transverse (6.2), and Vagina (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEACAM6 Gene

SOURCE GeneReport for Unigene cluster for CEACAM6 Gene Hs.466814

genes like me logo Genes that share expressions with CEACAM6: view

Orthologs for CEACAM6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM6 36
  • 98.84 (n)
  • 99.13 (a)
CEACAM6 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 25 (a)
ManyToMany
CEACAM1 37
  • 36 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg16 37
  • 20 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 10 (a)
ManyToMany
Species with no ortholog for CEACAM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM6 Gene

ENSEMBL:
Gene Tree for CEACAM6 (if available)
TreeFam:
Gene Tree for CEACAM6 (if available)

Paralogs for CEACAM6 Gene

Selected SIMAP similar genes for CEACAM6 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CEACAM6 Gene

genes like me logo Genes that share paralogs with CEACAM6: view

Variants for CEACAM6 Gene

Sequence variations from dbSNP and Humsavar for CEACAM6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2701 -- 41,771,194(+) agagt(A/G)tcaga utr-variant-3-prime
rs1130336 -- 41,756,949(+) CAGTT(C/G)CATGT reference, missense
rs1549960 -- 41,758,692(+) TTTTC(C/T)TCCCC intron-variant
rs1805223 -- 41,756,661(+) ACGCC(A/G)TTCAA synonymous-codon, reference
rs1971787 -- 41,763,724(+) TCTGA(C/T)TGAAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM6 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv911774 CNV Loss 21882294
nsv911775 CNV Gain 21882294
nsv2495 CNV Insertion 18451855
esv2718580 CNV Deletion 23290073

Relevant External Links for CEACAM6 Gene

HapMap Linkage Disequilibrium report
CEACAM6

Disorders for CEACAM6 Gene

(1) MalaCards Diseases for CEACAM6 Gene

Search for CEACAM6 Gene in MalaCards »

(2) University of Copenhagen DISEASES for CEACAM6 Gene

(28) Novoseek inferred disease relationships for CEACAM6 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 65.2 8
gastrointestinal carcinoma 60.2 1
colorectal carcinoma 54.6 5
adenocarcinoma 48.5 23
carcinoma 39.4 12

Relevant External Links for CEACAM6

Genetic Association Database (GAD)
CEACAM6
Human Genome Epidemiology (HuGE) Navigator
CEACAM6
genes like me logo Genes that share disorders with CEACAM6: view

No data available for UniProtKB/Swiss-Prot for CEACAM6 Gene

Publications for CEACAM6 Gene

  1. A specific heterotypic cell adhesion activity between members of carcinoembryonic antigen family, W272 and NCA, is mediated by N-domains. (PMID: 2022629) Oikawa S. … Nakazato H. (J. Biol. Chem. 1991) 3 23
  2. Carcinoembryonic antigen family members CEACAM6 and CEACAM7 are differentially expressed in normal tissues and oppositely deregulated in hyperplastic colorectal polyps and early adenomas. (PMID: 10666389) SchAPlzel S. … Thompson J. (Am. J. Pathol. 2000) 3 23
  3. Deregulated expression of the human tumor marker CEA and CEA family member CEACAM6 disrupts tissue architecture and blocks colonocyte differentiation. (PMID: 11896570) Ilantzis C. … Stanners C.P. (Neoplasia 2002) 3 23
  4. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. (PMID: 11994468) Singer B.B. … Obrink B. (J. Immunol. 2002) 3 23
  5. Expression of CEACAM6 in resectable colorectal cancer: a factor of independent prognostic significance. (PMID: 14512395) Jantscheff P. … Rochlitz C. (J. Clin. Oncol. 2003) 3 23

Products for CEACAM6 Gene

  • Copy Number PCR Panels: for CEACAM6
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CEACAM6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM6
    • Block miRNA regulation of CEACAM6 using miScript Target Protectors

    Sources for CEACAM6 Gene

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