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Aliases for CEACAM6 Gene

Aliases for CEACAM6 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 6 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen) 2 3
  • Normal Cross-Reacting Antigen 3 4
  • NCA 3 4
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 3
  • Non-Specific Crossreacting Antigen 4
  • Cluster Of Differentiation 66c 3
  • CD66c Antigen 4
  • CD66c 3
  • CEAL 3

External Ids for CEACAM6 Gene

Previous HGNC Symbols for CEACAM6 Gene

  • NCA

Previous GeneCards Identifiers for CEACAM6 Gene

  • GC19P042899
  • GC19P042652
  • GC19P046935
  • GC19P046952
  • GC19P046953
  • GC19P046954
  • GC19P042260
  • GC19P038692

Summaries for CEACAM6 Gene

Entrez Gene Summary for CEACAM6 Gene

  • This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

GeneCards Summary for CEACAM6 Gene

CEACAM6 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 6) is a Protein Coding gene. Diseases associated with CEACAM6 include Crohn's Disease and Colorectal Cancer. Among its related pathways are Innate Immune System and Cell surface interactions at the vascular wall. An important paralog of this gene is CEACAM5.

Gene Wiki entry for CEACAM6 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM6 Gene

Genomics for CEACAM6 Gene

Regulatory Elements for CEACAM6 Gene

Enhancers for CEACAM6 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G041784 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.8 +34.4 34428 1.7 CTCF RB1 SUZ12 ZIC2 RAD21 ZEB1 ZFHX2 GLIS2 ZNF143 SMC3 CEACAM6 HNRNPA1P52 CEACAM5 RABAC1 CEACAM4 ATP5SL ENSG00000268833
GH19G041798 1.7 FANTOM5 Ensembl dbSUPER 11.6 +47.5 47495 2.5 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF574 CEACAM4 CEACAM3 ZNF526 DEDD2 CCDC97 LYPD4 DMRTC2 CEACAM6 TMEM91
GH19G041800 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.5 +51.0 50986 2.3 HDAC1 CTCF PKNOX1 YY2 KLF17 ZIC2 HIC1 ZFHX2 RAD51 ZBTB33 CEACAM3 CEACAM4 DMRTC2 DEDD2 LYPD4 CEACAM6 CEACAM21 TMEM91 B9D2 TGFB1
GH19G041637 1.4 FANTOM5 Ensembl ENCODE 10.3 -112.4 -112356 2.9 CTCF ZMYM3 SIN3A ZSCAN9 TEAD3 ZNF766 PRDM10 EZH2 CAVIN1 MIER1 CEACAM7 MEGF8 CEACAM5 CEACAM6 ATP5SL BCKDHA EXOSC5 ENSG00000268582 ARHGEF1 B9D2
GH19G041778 1.1 ENCODE 12 +28.9 28925 2.1 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 YBX1 ZNF2 ZBTB7B ZNF207 ZNF574 ENSG00000269843 ZNF526 CEACAM6 LYPD4 DMRTC2 CEACAM7 CEACAM5 MEGF8 CEACAM4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM6 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM6 Gene

Chromosome:
19
Start:
41,750,977 bp from pter
End:
41,772,211 bp from pter
Size:
21,235 bases
Orientation:
Plus strand

Genomic View for CEACAM6 Gene

Genes around CEACAM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM6 Gene

Proteins for CEACAM6 Gene

  • Protein details for CEACAM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40199-CEAM6_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 6
    Protein Accession:
    P40199
    Secondary Accessions:
    • Q13774
    • Q14920
    • Q53XP7

    Protein attributes for CEACAM6 Gene

    Size:
    344 amino acids
    Molecular mass:
    37195 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CEACAM6 Gene

neXtProt entry for CEACAM6 Gene

Post-translational modifications for CEACAM6 Gene

  • Glycosylation at Asn104, posLast=111111, posLast=115115, Asn152, posLast=173173, posLast=197197, posLast=224224, posLast=256256, Asn274, Asn288, posLast=292292, and Asn309
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CEACAM6 (CEACAM-6/CD66c)
  • Cloud-Clone Corp. Antibodies for CEACAM6

Protein Products

  • Cloud-Clone Corp. Proteins for CEACAM6

Assay Products

  • Cloud-Clone Corp Assay Kits for CEACAM6

No data available for DME Specific Peptides for CEACAM6 Gene

Domains & Families for CEACAM6 Gene

Suggested Antigen Peptide Sequences for CEACAM6 Gene

Graphical View of Domain Structure for InterPro Entry

P40199

UniProtKB/Swiss-Prot:

CEAM6_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM6: view

Function for CEACAM6 Gene

Molecular function for CEACAM6 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) see CEA@

Gene Ontology (GO) - Molecular Function for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CEACAM6: view
genes like me logo Genes that share phenotypes with CEACAM6: view

Animal Model Products

CRISPR Products

miRNA for CEACAM6 Gene

miRTarBase miRNAs that target CEACAM6

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM6 Gene

Localization for CEACAM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM6 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM6 gene
Compartment Confidence
plasma membrane 5
extracellular 5
lysosome 4
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3220478
GO:0016020 membrane IEA --
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM6: view

Pathways & Interactions for CEACAM6 Gene

genes like me logo Genes that share pathways with CEACAM6: view

Gene Ontology (GO) - Biological Process for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 3220478
GO:0007267 cell-cell signaling TAS 3220478
GO:0008284 positive regulation of cell proliferation IMP 25171863
GO:0030335 positive regulation of cell migration IMP 25171863
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with CEACAM6: view

No data available for SIGNOR curated interactions for CEACAM6 Gene

Drugs & Compounds for CEACAM6 Gene

(2) Drugs for CEACAM6 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for CEACAM6 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM6: view

Transcripts for CEACAM6 Gene

mRNA/cDNA for CEACAM6 Gene

Unigene Clusters for CEACAM6 Gene

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM6 Gene

No ASD Table

Relevant External Links for CEACAM6 Gene

GeneLoc Exon Structure for
CEACAM6
ECgene alternative splicing isoforms for
CEACAM6

Expression for CEACAM6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM6 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.2), Minor Salivary Gland (x11.8), Lung (x10.1), Colon - Transverse (x6.2), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for CEACAM6 Gene

This gene is overexpressed in Neutrophil (37.7), Blymphocyte (14.2), and Lung (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEACAM6 Gene



NURSA nuclear receptor signaling pathways regulating expression of CEACAM6 Gene:

CEACAM6

SOURCE GeneReport for Unigene cluster for CEACAM6 Gene:

Hs.466814

Evidence on tissue expression from TISSUES for CEACAM6 Gene

  • Pancreas(4.8)
  • Intestine(4.5)
  • Liver(4.3)
  • Saliva(4)
  • Lung(3.2)
  • Stomach(2.8)
  • Blood(2.6)
  • Bone marrow(2.6)
genes like me logo Genes that share expression patterns with CEACAM6: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM6 Gene

Orthologs for CEACAM6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM6 34 35
  • 98.84 (n)
cow
(Bos Taurus)
Mammalia CEACAM1 35
  • 36 (a)
ManyToMany
-- 35
  • 25 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg16 35
  • 20 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 10 (a)
ManyToMany
Species where no ortholog for CEACAM6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM6 Gene

ENSEMBL:
Gene Tree for CEACAM6 (if available)
TreeFam:
Gene Tree for CEACAM6 (if available)

Paralogs for CEACAM6 Gene

Pseudogenes.org Pseudogenes for CEACAM6 Gene

genes like me logo Genes that share paralogs with CEACAM6: view

Variants for CEACAM6 Gene

Sequence variations from dbSNP and Humsavar for CEACAM6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000525945 -- 41,762,213(+) ATGAT(C/T)ACAGT reference, synonymous-codon
rs1000730833 -- 41,757,027(+) GTCAG(A/G)CCTGG intron-variant
rs1001036404 -- 41,756,765(+) CAACA(C/G)TCTAA reference, missense
rs1001158937 -- 41,765,266(+) GAGAT(A/T)CAGGT intron-variant
rs1001451553 -- 41,768,592(+) CATGG(A/C)CCGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM6 Gene

Variant ID Type Subtype PubMed ID
esv2718580 CNV deletion 23290073
esv2763205 CNV loss 21179565
esv3644394 CNV gain 21293372
esv3893209 CNV loss 25118596
nsv2495 CNV insertion 18451855
nsv477474 CNV novel sequence insertion 20440878
nsv522854 CNV gain 19592680
nsv579615 CNV gain 21841781
nsv960843 CNV duplication 23825009
nsv960844 CNV duplication 23825009

Variation tolerance for CEACAM6 Gene

Residual Variation Intolerance Score: 77.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM6 Gene

Disorders for CEACAM6 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CEACAM6 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
crohn's disease
  • ileitis
colorectal cancer
  • colorectal cancer, somatic
cholangiocarcinoma, susceptibility to
  • cholangiocarcinoma
reticulohistiocytic granuloma
  • reticulohistiocytoma
pancreas adenocarcinoma
  • pancreatic adenocarcinoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CEACAM6

Genetic Association Database (GAD)
CEACAM6
Human Genome Epidemiology (HuGE) Navigator
CEACAM6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM6
genes like me logo Genes that share disorders with CEACAM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM6 Gene

Publications for CEACAM6 Gene

  1. Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6. (PMID: 20047061) Stanke F. … TA1mmler B. (Hum. Genet. 2010) 3 22 64
  2. Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein. (PMID: 19329538) Kolla V. … Ballard P.L. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 3 22 64
  3. CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. (PMID: 19411761) Wang Y. … Lemoine N. (J. Clin. Invest. 2009) 3 22 64
  4. CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling. (PMID: 17653079) Han S.U. … Kim S.J. (Oncogene 2008) 3 22 64
  5. Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease. (PMID: 17960155) Callaghan M.J. … Pollard A.J. (Genes Immun. 2008) 3 46 64

Products for CEACAM6 Gene

Sources for CEACAM6 Gene

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