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Aliases for CEACAM6 Gene

Aliases for CEACAM6 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen) 2 3
  • Normal Cross-Reacting Antigen 3 4
  • NCA 3 4
  • Non-Specific Crossreacting Antigen 4
  • Cluster Of Differentiation 66c 3
  • CD66c Antigen 4
  • CD66c 3
  • CEAL 3

External Ids for CEACAM6 Gene

Previous HGNC Symbols for CEACAM6 Gene

  • NCA

Previous GeneCards Identifiers for CEACAM6 Gene

  • GC19P042899
  • GC19P042652
  • GC19P046935
  • GC19P046952
  • GC19P046953
  • GC19P046954
  • GC19P042260
  • GC19P038692

Summaries for CEACAM6 Gene

Entrez Gene Summary for CEACAM6 Gene

  • This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

GeneCards Summary for CEACAM6 Gene

CEACAM6 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 6 (Non-Specific Cross Reacting Antigen)) is a Protein Coding gene. Diseases associated with CEACAM6 include reticulohistiocytic granuloma and crohn's disease. Among its related pathways are Hemostasis and Degradation of the extracellular matrix. An important paralog of this gene is CEACAM8.

Gene Wiki entry for CEACAM6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM6 Gene

Genomics for CEACAM6 Gene

Regulatory Elements for CEACAM6 Gene

Genomic Location for CEACAM6 Gene

Chromosome:
19
Start:
41,750,977 bp from pter
End:
41,772,211 bp from pter
Size:
21,235 bases
Orientation:
Plus strand

Genomic View for CEACAM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM6 Gene

Proteins for CEACAM6 Gene

  • Protein details for CEACAM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40199-CEAM6_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 6
    Protein Accession:
    P40199
    Secondary Accessions:
    • Q13774
    • Q14920
    • Q53XP7

    Protein attributes for CEACAM6 Gene

    Size:
    344 amino acids
    Molecular mass:
    37195 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CEACAM6 Gene

Proteomics data for CEACAM6 Gene at MOPED

Post-translational modifications for CEACAM6 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 115, Asn 152, Asn 173, Asn 197, Asn 224, Asn 256, Asn 274, Asn 288, Asn 292, and Asn 309
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM6 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CEACAM6 (CEACAM-6/CD66c)

No data available for DME Specific Peptides for CEACAM6 Gene

Domains & Families for CEACAM6 Gene

Suggested Antigen Peptide Sequences for CEACAM6 Gene

Graphical View of Domain Structure for InterPro Entry

P40199

UniProtKB/Swiss-Prot:

CEAM6_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM6: view

Function for CEACAM6 Gene

Molecular function for CEACAM6 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) see CEA@

Gene Ontology (GO) - Molecular Function for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21982860
genes like me logo Genes that share ontologies with CEACAM6: view

Phenotypes for CEACAM6 Gene

genes like me logo Genes that share phenotypes with CEACAM6: view

Animal Model Products

CRISPR Products

miRNA for CEACAM6 Gene

miRTarBase miRNAs that target CEACAM6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM6 Gene

Localization for CEACAM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM6 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM6 Gene COMPARTMENTS Subcellular localization image for CEACAM6 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
extracellular 1
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25645918
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane TAS 3220478
GO:0031225 anchored component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM6: view

Pathways & Interactions for CEACAM6 Gene

genes like me logo Genes that share pathways with CEACAM6: view

Pathways by source for CEACAM6 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat

Gene Ontology (GO) - Biological Process for CEACAM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction TAS 3220478
GO:0007267 cell-cell signaling TAS 3220478
GO:0007596 blood coagulation TAS --
GO:0050900 leukocyte migration TAS --
genes like me logo Genes that share ontologies with CEACAM6: view

No data available for SIGNOR curated interactions for CEACAM6 Gene

Drugs & Compounds for CEACAM6 Gene

(2) Drugs for CEACAM6 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Gemcitabine Approved Pharma Ribonucleotide reductase and DNA synthesis inhibitor, Nucleoside Analogs 1800
Calcium Nutra 0

(2) Additional Compounds for CEACAM6 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Paraffin
Phosphatidylinositol
genes like me logo Genes that share compounds with CEACAM6: view

Transcripts for CEACAM6 Gene

mRNA/cDNA for CEACAM6 Gene

Unigene Clusters for CEACAM6 Gene

Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM6 Gene

No ASD Table

Relevant External Links for CEACAM6 Gene

GeneLoc Exon Structure for
CEACAM6
ECgene alternative splicing isoforms for
CEACAM6

Expression for CEACAM6 Gene

mRNA expression in normal human tissues for CEACAM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM6 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.2), Minor Salivary Gland (x11.8), Lung (x10.1), Colon - Transverse (x6.2), and Vagina (x4.2).

Protein differential expression in normal tissues from HIPED for CEACAM6 Gene

This gene is overexpressed in Neutrophil (37.7), Blymphocyte (14.2), and Lung (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEACAM6 Gene



SOURCE GeneReport for Unigene cluster for CEACAM6 Gene Hs.466814

genes like me logo Genes that share expression patterns with CEACAM6: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CEACAM6 Gene

Orthologs for CEACAM6 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM6 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM6 35
  • 98.84 (n)
  • 99.13 (a)
CEACAM6 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 25 (a)
ManyToMany
CEACAM1 36
  • 36 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 10 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg16 36
  • 20 (a)
ManyToMany
Species with no ortholog for CEACAM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM6 Gene

ENSEMBL:
Gene Tree for CEACAM6 (if available)
TreeFam:
Gene Tree for CEACAM6 (if available)

Paralogs for CEACAM6 Gene

Pseudogenes.org Pseudogenes for CEACAM6 Gene

genes like me logo Genes that share paralogs with CEACAM6: view

Variants for CEACAM6 Gene

Sequence variations from dbSNP and Humsavar for CEACAM6 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2701 -- 41,771,194(+) agagt(A/G)tcaga utr-variant-3-prime
rs1549960 -- 41,758,692(+) TTTTC(C/T)TCCCC intron-variant
rs1805223 -- 41,756,661(+) ACGCC(A/G)TTCAA synonymous-codon, reference
rs1971787 -- 41,763,724(+) TCTGA(C/T)TGAAC intron-variant
rs2116943 -- 41,769,580(+) tcttt(C/T)aagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM6 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
nsv911774 CNV Loss 21882294
nsv911775 CNV Gain 21882294
nsv2495 CNV Insertion 18451855
esv2718580 CNV Deletion 23290073

Variation tolerance for CEACAM6 Gene

Residual Variation Intolerance Score: 77.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.01; 20.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM6 Gene

HapMap Linkage Disequilibrium report
CEACAM6

PCR Panel Products

  • Copy Number PCR Panels: for CEACAM6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM6 Gene

Disorders for CEACAM6 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CEACAM6 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
reticulohistiocytic granuloma
  • reticulohistiocytoma
crohn's disease
  • enteritis
cholangiocarcinoma
  • bile duct carcinoma
colorectal cancer
  • colorectal cancer, somatic
- elite association

Relevant External Links for CEACAM6

Genetic Association Database (GAD)
CEACAM6
Human Genome Epidemiology (HuGE) Navigator
CEACAM6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM6
genes like me logo Genes that share disorders with CEACAM6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM6 Gene

Publications for CEACAM6 Gene

  1. Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6. (PMID: 20047061) Stanke F. … TA1mmler B. (Hum. Genet. 2010) 23 67
  2. Crohn's disease adherent-invasive Escherichia coli colonize and induce strong gut inflammation in transgenic mice expressing human CEACAM. (PMID: 19737864) Carvalho F.A. … Darfeuille-Michaud A. (J. Exp. Med. 2009) 23 67
  3. Carcinoembryonic cell adhesion molecule 6 in human lung: regulated expression of a multifunctional type II cell protein. (PMID: 19329538) Kolla V. … Ballard P.L. (Am. J. Physiol. Lung Cell Mol. Physiol. 2009) 23 67
  4. CEACAM6 attenuates adenovirus infection by antagonizing viral trafficking in cancer cells. (PMID: 19411761) Wang Y. … Lemoine N. (J. Clin. Invest. 2009) 23 67
  5. CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling. (PMID: 17653079) Han S.U. … Kim S.J. (Oncogene 2008) 23 67

Products for CEACAM6 Gene

  • Copy Number PCR Panels: for CEACAM6
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CEACAM6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM6
    • Block miRNA regulation of CEACAM6 using miScript Target Protectors

    Sources for CEACAM6 Gene

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