Aliases for CEACAM5 Gene
External Ids for CEACAM5 Gene
Previous HGNC Symbols for CEACAM5 Gene
Previous GeneCards Identifiers for CEACAM5 Gene
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
GeneCards Summary for CEACAM5 Gene
CEACAM5 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with CEACAM5 include Colorectal Cancer and Urachal Cancer. Among its related pathways are Natural Killer Cell Receptors: Human Target Cell ?�� NK Cell Ligand-Receptor Interactions and NF-kappaB Signaling. GO annotations related to this gene include protein homodimerization activity and GPI anchor binding. An important paralog of this gene is CEACAM8.
UniProtKB/Swiss-Prot for CEACAM5 Gene
Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.