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Aliases for CEACAM5 Gene

Aliases for CEACAM5 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 2 3
  • CEA 3 4 6
  • Meconium Antigen 100 3 4
  • Carcinoembryonic Antigen 4
  • CD66e Antigen 4
  • CD66e 3

External Ids for CEACAM5 Gene

Previous HGNC Symbols for CEACAM5 Gene

  • CEA

Previous GeneCards Identifiers for CEACAM5 Gene

  • GC19P042852
  • GC19P042604
  • GC19P046888
  • GC19P046904
  • GC19P042212
  • GC19P038644

Summaries for CEACAM5 Gene

Entrez Gene Summary for CEACAM5 Gene

  • Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the CEA gene family, see CEACAM1 (MIM 109770).[supplied by OMIM, Oct 2009]

GeneCards Summary for CEACAM5 Gene

CEACAM5 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with CEACAM5 include urethral diverticulum and urachal cancer. Among its related pathways are Adhesion and Lymphocyte Signaling. GO annotations related to this gene include identical protein binding. An important paralog of this gene is CEACAM8.

UniProtKB/Swiss-Prot for CEACAM5 Gene

  • Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

Gene Wiki entry for CEACAM5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM5 Gene

Genomics for CEACAM5 Gene

Regulatory Elements for CEACAM5 Gene

Genomic Location for CEACAM5 Gene

Start:
41,576,273 bp from pter
End:
41,730,517 bp from pter
Size:
154,245 bases
Orientation:
Plus strand

Genomic View for CEACAM5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM5 Gene

Proteins for CEACAM5 Gene

  • Protein details for CEACAM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P06731-CEAM5_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 5
    Protein Accession:
    P06731
    Secondary Accessions:
    • H9KVA7

    Protein attributes for CEACAM5 Gene

    Size:
    702 amino acids
    Molecular mass:
    76795 Da
    Quaternary structure:
    • Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
    SequenceCaution:
    • Sequence=AAA62835.1; Type=Frameshift; Positions=359, 361; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEACAM5 Gene

    Alternative splice isoforms for CEACAM5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM5 Gene

Proteomics data for CEACAM5 Gene at MOPED

Post-translational modifications for CEACAM5 Gene

  • Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate
  • Glycosylation at Asn104, Asn115, Asn152, Asn182, Asn197, Asn204, Asn208, Asn246, Asn256, Asn274, Asn288, Asn292, Asn309, Asn330, Asn351, Asn360, Asn375, Asn432, Asn466, Asn480, Asn508, Asn529, Asn553, Asn560, Asn580, Asn612, Asn650, and Asn665
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEACAM5 Gene

Domains for CEACAM5 Gene

Gene Families for CEACAM5 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • ISET :Immunoglobulin superfamily / I-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CEACAM5 Gene

Suggested Antigen Peptide Sequences for CEACAM5 Gene

Graphical View of Domain Structure for InterPro Entry

P06731

UniProtKB/Swiss-Prot:

CEAM5_HUMAN :
  • P06731
Domain:
  • Contains 7 Ig-like (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM5: view

Function for CEACAM5 Gene

Molecular function for CEACAM5 Gene

GENATLAS Biochemistry: carcinoembryonic antigen-related cell adhesion molecule 5
UniProtKB/Swiss-Prot Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.

Gene Ontology (GO) - Molecular Function for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0034235 GPI anchor binding IMP 10931872
GO:0042802 identical protein binding IPI 10864933
GO:0042803 protein homodimerization activity IDA 18086185
genes like me logo Genes that share ontologies with CEACAM5: view

miRNA for CEACAM5 Gene

miRTarBase miRNAs that target CEACAM5

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEACAM5 Gene

Localization for CEACAM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM5 Gene

Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM5 Gene COMPARTMENTS Subcellular localization image for CEACAM5 gene
Compartment Confidence
plasma membrane 5
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IDA 10931872
GO:0016323 basolateral plasma membrane IDA 15052268
GO:0031225 anchored component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
GO:0071575 integral component of external side of plasma membrane IDA 10864933
genes like me logo Genes that share ontologies with CEACAM5: view

Pathways for CEACAM5 Gene

genes like me logo Genes that share pathways with CEACAM5: view

Pathways by source for CEACAM5 Gene

2 Cell Signaling Technology pathways for CEACAM5 Gene
1 GeneGo (Thomson Reuters) pathway for CEACAM5 Gene

Gene Ontology (GO) - Biological Process for CEACAM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010832 negative regulation of myotube differentiation IDA 10931872
GO:0034109 homotypic cell-cell adhesion IDA 10864933
GO:0043066 negative regulation of apoptotic process IDA 11448920
GO:2000811 negative regulation of anoikis IDA 10910050
genes like me logo Genes that share ontologies with CEACAM5: view

Compounds for CEACAM5 Gene

(1) Drugbank Compounds for CEACAM5 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL
target

(58) Novoseek inferred chemical compound relationships for CEACAM5 Gene

Compound -log(P) Hits PubMed IDs
labetuzumab 79.2 3
b 723 65.2 18
slex 49.3 13
mucicarmine 47.9 1
5fluorouracil 47.3 7
genes like me logo Genes that share compounds with CEACAM5: view

Transcripts for CEACAM5 Gene

Unigene Clusters for CEACAM5 Gene

Carcinoembryonic antigen-related cell adhesion molecule 5:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM5 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
SP1:
SP2: - - - - - - - - - - - - - - -
SP3:
SP4:
SP5: -
SP6: - - - - - - - - -
SP7:
SP8: - - - - -
SP9:

Relevant External Links for CEACAM5 Gene

GeneLoc Exon Structure for
CEACAM5
ECgene alternative splicing isoforms for
CEACAM5

Expression for CEACAM5 Gene

mRNA expression in normal human tissues for CEACAM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM5 Gene

This gene is overexpressed in Colon - Transverse (30.9) and Esophagus - Mucosa (11.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEACAM5 Gene

SOURCE GeneReport for Unigene cluster for CEACAM5 Gene Hs.709196

mRNA Expression by UniProt/SwissProt for CEACAM5 Gene

P06731-CEAM5_HUMAN
Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon
genes like me logo Genes that share expressions with CEACAM5: view

Orthologs for CEACAM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
CEACAM5 35
  • 98.77 (n)
  • 97.44 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 36 (a)
ManyToMany
CEACAM1 36
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam1 36
  • 43 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 39 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch211-264f5.6 35
  • 44.03 (n)
  • 32.35 (a)
Species with no ortholog for CEACAM5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEACAM5 Gene

ENSEMBL:
Gene Tree for CEACAM5 (if available)
TreeFam:
Gene Tree for CEACAM5 (if available)

Paralogs for CEACAM5 Gene

genes like me logo Genes that share paralogs with CEACAM5: view

Variants for CEACAM5 Gene

Sequence variations from dbSNP and Humsavar for CEACAM5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs9621 -- 41,727,239(+) CATCT(A/G)GAACT missense, reference
rs882152 -- 41,706,933(-) GCCGA(A/G)GTGAC upstream-variant-2KB
rs889365 -- 41,711,432(+) AATGA(A/G)TGAAG intron-variant
rs1115885 -- 41,724,525(+) ggtac(A/G)aattg intron-variant
rs1593086 -- 41,716,490(+) AGCTG(C/T)CAATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM5 Gene

Variant ID Type Subtype PubMed ID
esv2718577 CNV Deletion 23290073
nsv522854 CNV Gain 19592680
nsv482220 CNV Gain 20164927

Relevant External Links for CEACAM5 Gene

HapMap Linkage Disequilibrium report
CEACAM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM5 Gene

Disorders for CEACAM5 Gene

(1) University of Copenhagen DISEASES for CEACAM5 Gene

(96) Novoseek inferred disease relationships for CEACAM5 Gene

Disease -log(P) Hits PubMed IDs
colorectal cancer 83.2 197
colorectal carcinoma 80.9 82
metastasis 80.3 190
adenocarcinoma 77.3 136
tumors 75.8 271
genes like me logo Genes that share disorders with CEACAM5: view

No data available for UniProtKB/Swiss-Prot for CEACAM5 Gene

Publications for CEACAM5 Gene

  1. The specificity for the differentiation blocking activity of carcinoembryonic antigen resides in its glycophosphatidyl-inositol anchor. (PMID: 10931872) Screaton R.A. … Stanners C.P. (J. Cell Biol. 2000) 3 23
  2. Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells. (PMID: 11448920) Soeth E. … Juhl H. (Clin. Cancer Res. 2001) 3 23
  3. Recruitment of CD55 and CD66e brush border-associated glycosylphosphatidylinositol-anchored proteins by members of the Afa/Dr diffusely adhering family of Escherichia coli that infect the human polarized intestinal Caco-2/TC7 cells. (PMID: 10816511) Guignot J. … Servin A.L. (Infect. Immun. 2000) 3 23
  4. Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth. (PMID: 11964079) Wirth T. … Juhl H. (Clin. Exp. Metastasis 2002) 3 23
  5. Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. (PMID: 12420218) Hampton R. … Juhl H. (Oncogene 2002) 3 23

Products for CEACAM5 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lung Cancer in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CEACAM5
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM5
    • Block miRNA regulation of CEACAM5 using miScript Target Protectors

    Sources for CEACAM5 Gene

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