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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM5 Gene

protein-coding   GIFtS: 63
GCID: GC19P042212

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...


(Previous symbol: CEA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 51 2
CEA1 2 3 5
Meconium Antigen 1002 3
CD66e2
Carcinoembryonic Antigen3
CD66e Antigen3

External Ids:    HGNC: 18171   Entrez Gene: 10482   Ensembl: ENSG000001053887   OMIM: 1148905   UniProtKB: P067313   

Export aliases for CEACAM5 gene to outside databases

Previous GC identifers: GC19P042852 GC19P042604 GC19P046888 GC19P046904 GC19P038644


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEACAM5 Gene:
Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the
CEA gene family, see CEACAM1 (MIM 109770).(supplied by OMIM, Oct 2009)

GeneCards Summary for CEACAM5 Gene: 
CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) is a protein-coding gene. Diseases associated with CEACAM5 include urachal cancer, and gastric linitis plastica, and among its related super-pathways are Cell adhesion Cell-matrix glycoconjugates. GO annotations related to this gene include identical protein binding. An important paralog of this gene is PSG9.

UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731
Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor
for E.coli Dr adhesins

Gene Wiki entry for CEACAM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM5 gene promoter:
         c-Fos   AP-1   NRSF form 1   NF-kappaB1   NF-kappaB   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEACAM5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.2

CEACAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042212:  view genomic region     (about GC identifiers)

Start:
42,212,504 bp from pter      End:
42,234,437 bp from pter
Size:
21,934 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 5 precursor  
Size: 702 amino acids; 76795 Da
Subunit: Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor
Sequence caution: Sequence=AAA62835.1; Type=Frameshift; Positions=359, 361;
4 PDB 3D structures from and Proteopedia for CEACAM5:
1E07 (3D)        2QSQ (3D)        2QST (3D)        2VER (3D)    

Explore the universe of human proteins at neXtProt for CEACAM5: NX_P06731

Explore proteomics data for CEACAM5 at MOPED 

Post-translational modifications:

  • UniProtKB: Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P06731

  • CEACAM5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEACAM5 Protein Expression
    REFSEQ proteins: NP_004354.2  
    ENSEMBL proteins: 
     ENSP00000381600   ENSP00000221992   ENSP00000385072   ENSP00000468997   ENSP00000473252  

    Human Recombinant Protein Products for CEACAM5: 
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    OriGene Purified Protein for CEACAM5
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    Novus Biologicals CEACAM5 Lysate
    Sino Biological Recombinant Protein for CEACAM5
    Sino Biological Cell Lysate for CEACAM5 
    ProSpec Recombinant Protein for CEACAM5
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral to plasma membrane TAS3814146
    GO:0016323basolateral plasma membrane IDA15052268
    GO:0031225anchored to membrane IEA--

    CEACAM5 for ontologies           About GeneDecksing



    CEACAM5 Antibody Products: 
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    Browse ELISAs at Cloud-Clone Corp. 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5/6 InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P06731

    ProtoNet protein and cluster: P06731

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 7 Ig-like (immunoglobulin-like) domains


    CEACAM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEAM5_HUMAN, P06731
    Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor
    for E.coli Dr adhesins

         Genatlas biochemistry entry for CEACAM5:
    carcinoembryonic antigen-related cell adhesion molecule 5

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0042802identical protein binding IPI18086185
         
    CEACAM5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEACAM5 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEACAM5 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CEACAM5 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Cell-matrix glycoconjugates
    Cell adhesion Cell-matrix glycoconjugates0.97
    2Adhesion
    Adhesion
    3Lymphocyte Signaling
    Lymphocyte Signaling

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CEACAM5
        Cell adhesion Cell-matrix glycoconjugates


    2 Cell Signaling Technology (CST) Pathways for CEACAM5
        Lymphocyte Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for CEACAM5
        Cell adhesion Cell-matrix glycoconjugates




    CEACAM5 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CEACAM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/11 Interacting proteins for CEACAM5 (P067311, 2, 3 ENSP000002219924) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTCHD2Q9P2K93, ENSP000002944844I2D: score=1 STRING: ENSP00000294484
    HNRNPMP522723, ENSP000003253764I2D: score=1 STRING: ENSP00000325376
    EWSR1Q018443, ENSP000003810314I2D: score=2 STRING: ENSP00000381031
    CEACAM5P067311EBI-3914938,EBI-3914938
    SELEENSP000003317364STRING: ENSP00000331736
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CEACAM5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEACAM5 (CEAM5)

    1 DrugBank Compound for CEACAM5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL-- --target--10592235

    10/58 Novoseek inferred chemical compound relationships for CEACAM5 gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    labetuzumab 79.2 3 15592930 (2), 15809485 (1)
    b 723 65.2 21 8941003 (4), 10431845 (4), 7868083 (3), 1689123 (2) (see all 9)
    slex 49.3 19 17697728 (4), 11125284 (2), 11291879 (2), 12017332 (2) (see all 6)
    mucicarmine 47.9 1 10199475 (1)
    5fluorouracil 47.3 10 11943891 (1), 9538153 (1), 2314825 (1), 11448920 (1) (see all 7)
    leucovorin 44.2 3 18577244 (1), 15360055 (1), 12420861 (1)
    polynucleotide 39.5 9 7712333 (4), 9053029 (1), 7621253 (1), 8118800 (1)
    crcs 35.3 3 1962152 (2), 15221959 (1)
    irinotecan 33.2 4 20121626 (2), 16601395 (1)
    paraffin 29.3 11 12763211 (2), 2187320 (2), 1965432 (1), 11894632 (1) (see all 7)

    Search CenterWatch for drugs/clinical trials and news about CEACAM5 / CEAM5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEACAM5 gene: 
    NM_004363.2  

    Unigene Cluster for CEACAM5:

    Carcinoembryonic antigen-related cell adhesion molecule 5
    Hs.709196  [show with all ESTs]
    Unigene Representative Sequence: NM_004363
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398599 ENST00000221992(uc010ehz.1 uc002orj.1 uc002orl.3)
    ENST00000460121 ENST00000596606 ENST00000405816 ENST00000595403 ENST00000595113

    miRNA
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM5

    Additional mRNA sequence: 

    AK223101.1 AK310844.1 BC034671.1 CR749337.1 M15042.1 M16234.1 M17191.1 M29540.1 
    X16455.1 

    24/27 DOTS entries (see all 27):

    DT.100822611  DT.420280  DT.121426886  DT.95290266  DT.92439265  DT.86845447  DT.95214825  DT.95301065 
    DT.121426861  DT.95289952  DT.121426853  DT.95311400  DT.121426870  DT.121426903  DT.91682705  DT.95286776 
    DT.98131717  DT.98131718  DT.100035515  DT.40117512  DT.87017412  DT.87017415  DT.120658830  DT.121426872 

    24/574 AceView cDNA sequences (see all 574):

    AI634287 AW819835 BM839383 X16455 AW859600 AI640689 BM786353 BF760001 
    BG983297 M16234 AA053595 M15042 BM850032 AL702861 BI012906 AI940526 
    BM751729 BM836430 BQ083565 BM836657 BM836866 BM751377 BM836104 BM828560 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM5 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                                                                                                                          
    SP2:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                 
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                    -                     


    ECgene alternative splicing isoforms for CEACAM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEACAM5 expression in normal human tissues (normalized intensities)      CEACAM5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEACAM5 Expression
    About this image


    CEACAM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Epithelium (Uncategorized)    fully expand to see all 4 entries
             vagina ; squamous epithelial cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Oral Cavity (Gastrointestinal Tract)    fully expand to see all 2 entries
             oral mucosa ; squamous epithelial cells   
             TONGUE   
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             lung ; pneumocytes   
             Trachea   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   

    See CEACAM5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEACAM5

    SOURCE GeneReport for Unigene cluster: Hs.709196

    UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731
    Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon

        SABiosciences Expression via Pathway-Focused PCR Array including CEACAM5: 
              Lung Cancer in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEACAM5 gene from 1/4 species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii ceacam11 carcinoembryonic antigen-related cell adhesion molecule more 42.78(n)
    30.17(a)
      114465  NM_001113794.1  NP_001107266.1 
            Species with no ortholog for CEACAM5

    ENSEMBL Gene Tree for CEACAM5 (if available)
    TreeFam Gene Tree for CEACAM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEACAM5 gene
    PSG92  PSG82  CEACAM42  PSG112  PSG32  CEACAM72  CEACAM212  PSG12  
    PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    18/26 SIMAP similar genes for CEACAM5 using alignment to 5 protein entries:     CEAM5_HUMAN (see all proteins) (see all similar genes):
    CEACAM3    CEACAM6    CEA    CEACAM1    CEACAM8    CEACAM7
    DHFRP2    PSGII    PSG    PSG11    CEACAM4    PSG1
    PSG2    CEACAM21    PSG5    PSG8    PSG6    PSG9

    CEACAM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/657 SNPs in CEACAM5 are shown (see all 657)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0560294
    ----see VAR_0560292 G R mis40--------
    rs1138346801,2
    F--42210621(+) GGGCTC/TACCGA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs104196071,2
    C,F,H--42210659(+) ACATGT/GGCATG 1 -- us2k15Minor allele frequency- G:0.01NS EA WA 536
    rs745164521,2
    C,F--42210733(+) CCCCAC/TTTCCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1115021631,2
    C,F--42210785(+) GCCTCC/TCCAGG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1886650341,2
    --42210802(+) TGACCA/TCCCTC 1 -- us2k10--------
    rs38101521,2
    C,F,H--42210812(+) CAGCCG/AGGCCC 1 -- us2k15Minor allele frequency- A:0.03NS EA 532
    rs72585241,2
    C,F,H--42210824(+) CAGCCC/TAGCAG 1 -- us2k110Minor allele frequency- T:0.15NS EA NA WA 538
    rs8821521,2
    C,F,H--42210852(-) GCCGAG/AGTGAC 1 -- us2k15Minor allele frequency- A:0.02NS EA WA 534
    rs1117128991,2
    C--42211005(+) CCCCCC/TCCTTC 1 -- us2k11Minor allele frequency- T:0.50CSA 2

    HapMap Linkage Disequilibrium report for CEACAM5 (42212504 - 42234437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CEACAM5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718577CNV Deletion23290073
    nsv522854CNV Gain19592680
    nsv482220CNV Gain20164927

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 114890    OMIM disorders: --

    20/94 diseases for CEACAM5 (see all 94):    About MalaCards
    urachal cancer    gastric linitis plastica    esophageal disease    linitis plastica
    urachal adenocarcinoma    urethral diverticulum    extragonadal germ cell tumor    splenic infarction
    pancreatic cystadenoma    arc syndrome    secretory meningioma    warthin tumor
    peritonitis    malignant mesothelioma    acinar cell carcinoma    gallbladder cancer
    primary peritoneal carcinoma    papillary adenocarcinoma    adenomatoid tumor    pseudomyxoma peritonei

    1 disease from the University of Copenhagen DISEASES database for CEACAM5:
    Colorectal cancer

    CEACAM5 for disorders           About GeneDecksing

    10/96 Novoseek inferred disease relationships for CEACAM5 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 83.2 287 1293545 (7), 11898807 (5), 11289125 (5), 20216474 (4) (see all 99)
    colorectal carcinoma 80.9 105 8439497 (4), 12854170 (4), 11948229 (4), 10211983 (3) (see all 56)
    metastasis 80.3 433 11948229 (5), 14592671 (5), 10770562 (4), 16719189 (4) (see all 99)
    adenocarcinoma 77.3 152 15082298 (5), 2328062 (4), 15337038 (4), 12521132 (3) (see all 93)
    tumors 75.8 729 14981971 (6), 1290028 (6), 7914825 (5), 10858386 (5) (see all 99)
    gastric cancer 72.2 138 19688060 (5), 8908563 (5), 8908719 (4), 9660027 (4) (see all 68)
    nsclc 70.8 138 10808698 (5), 15363304 (5), 16809939 (4), 18646695 (4) (see all 59)
    colon carcinoma 67.8 33 1477074 (2), 7688074 (2), 18375392 (2), 15510175 (2) (see all 21)
    colon cancer 65.8 58 11964079 (4), 8141873 (3), 2314825 (3), 12636102 (3) (see all 30)
    cancer 65.6 216 15017899 (9), 10601548 (4), 16223370 (3), 9704713 (3) (see all 99)


    Export disorders for CEACAM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEACAM5 gene, integrated from 9 sources (see all 1048):
    (articles sorted by number of sources associating them with CEACAM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation. (PubMed id 18086185)1, 2 Korotkova N.... Matthews S. (2008)
    2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    3. Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23. (PubMed id 10854848)1, 2 Boehm M.K. and Perkins S.J. (2000)
    4. Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression. (PubMed id 2342461)1, 2 Schrewe H.... Zimmermann W. (1990)
    5. Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. (PubMed id 3220478)1, 2 Barnett T.... Elting J.J. (1988)
    6. Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. (PubMed id 3670312)1, 2 Beauchemin N.... Stanners C.P. (1987)
    7. Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. (PubMed id 3814146)1, 2 Oikawa S.... Kosaki G. (1987)
    8. Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure. (PubMed id 3033671)1, 2 Zimmermann W.... von Kleist S. (1987)
    9. Lead time of carcinoembryonic antigen elevation in th e postoperative follow-up of colorectal cancer did not affect the survival rate after recurrence. (PubMed id 20162425)1, 9 Chen C.H....Wang J.Y. (2010)
    10. Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth. (PubMed id 11964079)1, 9 Wirth T....Juhl H. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1048 HGNC: 1817 AceView: CEACAM5 Ensembl:ENSG00000105388 euGenes: HUgn1048
    ECgene: CEACAM5 H-InvDB: CEACAM5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEACAM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEACAM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEACAM5 gene:
    Search GeneIP for patents involving CEACAM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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