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CEACAM5 Gene

protein-coding GIFtS: 60

GC19P046904

carcinoembryonic antigen-related cell adhesion molecule 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CEA)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CD66e ^¹, ²
CEA ^², ³, ⁵
DKFZp781M2392 ^²

Descriptions
CD66e antigen ^³
Carcinoembryonic antigen ^³
Meconium antigen 100 ^³
carcinoembryonic antigen-related cell adhesion molecule 5 ^²

External Ids
HGNC: 1817¹
Entrez Gene: 1048²
UniProtKB: P06731³
Ensembl: ENSG00000105388⁷

Search outside databases for aliases for CEACAM5 gene

Previous GC identifers: GC19P042852 GC19P042604 GC19P046888

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731

Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular

signaling. Receptor for E.coli Dr adhesins

Gene Wiki entry for CEACAM5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CEACAM5 gene

Entrez Gene cytogenetic band: 19q13.1-q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.1-q13.2

CEACAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P046904: (about GC identifiers)

Start:	46,904,370 bp from pter
End:	46,926,277 bp from pter
Size:	21,908 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731 (See protein sequence)

Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 5 precursor

Size: 702 amino acids; 76796 Da

Subunit: Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor

PDB structures from and Proteopedia :

1E07 (3D)

2QSQ (3D)

2QST (3D)

2VER (3D)

Post-translational modifications:

Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate¹

REFSEQ proteins: NP_004354.2

ENSEMBL proteins:

ENSP00000367423 ENSP00000221992 ENSP00000385072

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CEACAM5 (CEACAM-5/CD66e)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CEACAM 5 + 6, CD66c + CD66e, pan CEACAM, CD66a + CD66c + CD66d + CD66e, Carcino Embryonic Antigen CEA)
	Human Recombinant Proteins from Abnova (CEACAM5)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0005887	integral to plasma membrane	TAS	3814146
GO:0031225	anchored to membrane	IEA	--

About this table

Antibodies for CEACAM5:

	Invitrogen Antibodies for CEACAM5
	Millipore Mono- and Polyclonal Antibodies for the study of CEACAM5
	Sigma-Aldrich Antibodies for CEACAM5
	R&D Systems Antibodies for CEACAM5 (CEACAM-5/CD66e)
	Cell Signaling Technology (CST) Antibodies for CEACAM5 (CEA)
	Antibodies from Abcam (CEACAM 5 + 6, CD66c + CD66e, pan CEACAM, CD66a + CD66c + CD66d + CD66e, Carcino Embryonic Antigen CEA), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CEACAM5)
	Novus Biologicals Antibodies for CEACAM5

Assays for CEACAM5:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P06731

ProtoNet protein and cluster: P06731

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731

Similarity: Belongs to the immunoglobulin superfamily. CEA family

Similarity: Contains 7 Ig-like (immunoglobulin-like) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CEACAM5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004363

Applied Biosystems Silencer® siRNAs for CEACAM5

Sigma-Aldrich siRNA and siRNA Panels for CEACAM5

Sigma-Aldrich shRNA Panels and shRNA for CEACAM5

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CEACAM5
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004363
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004363
untagged cDNA clone in CMV expression vector: NM_004363

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004363

UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731

Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular

signaling. Receptor for E.coli Dr adhesins

Genatlas biochemistry entry for CEACAM5:

carcinoembryonic antigen-related cell adhesion molecule 5

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for CEACAM5

5/8 Interacting proteins for CEACAM5 (P06731² ENSP00000221992³) via UniProtKB, MINT, and/or STRING (see all 8 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
APOH	ENSP00000205948³	STRING (score=.931)
TRMT2A	ENSP00000252136³	STRING (score=.708)
--	152143604²	MINT-7046422
--	152143602²	MINT-7045726
--	Q9BWA2²	MINT-67468
--	152143600²	MINT-7042030
--	152143608²	MINT-7046442
--	152143606²	MINT-7046473

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CEACAM5
10/34 Novoseek chemical compound relationships for CEACAM5 gene (see all 34 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
labetuzumab	81.00	3	15592930 (2), 15809485 (1)
b 723	64.01	20	8941003 (4), 10431845 (4), 7868083 (3), 1689123 (2) (see all 8)
slex	50.63	19	17697728 (4), 11125284 (2), 11291879 (2), 12017332 (2) (see all 6)
mucicarmine	49.47	1	10199475 (1)
polynucleotide	40.93	9	7712333 (4), 9053029 (1), 7621253 (1), 8118800 (1)
crcs	38.43	3	1962152 (2), 15221959 (1)
hematoxylin	16.98	5	17101257 (1), 16425381 (1), 19189191 (1), 10199475 (1)
cytosine	11.06	3	11507067 (1), 10608354 (1), 19118047 (1)
gold	4.79	4	17002090 (1)
steroid	4.47	5	7684339 (2), 10427956 (1), 11553856 (1), 8070597 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CEACAM5)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004363

Sigma-Aldrich siRNA and siRNA Panels for CEACAM5

Sigma-Aldrich shRNA Panels and shRNA for CEACAM5

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004363

REFSEQ mRNAs for CEACAM5 gene:

NM_004363.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004363

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004363
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004363
                                 untagged cDNA clone in CMV expression vector: NM_004363

Additional cDNA sequence:

AK223101.1 AK310844.1 BC034671.1 CR749337.1 M15042.1 M16234.1 M17191.1 M29540.1

X16455.1

24/30 DOTS entries (see all 30 ):

DT.100822611 DT.420280 DT.121426886 DT.95290266 DT.92439265 DT.86845447 DT.95214825 DT.95301065

DT.91682705 DT.121426861 DT.121426895 DT.95289952 DT.121426853 DT.95311400 DT.121426870 DT.121426903

DT.95286776 DT.95338629 DT.98131717 DT.98131718 DT.100035515 DT.40117512 DT.87017412 DT.87017415

24/574 AceView cDNA sequences (see all 574 ):

AW859600 BM828560 AA053595 AI940526 AI634287 AL702861 AW819835 BM751729

AW071196 AA055606 BM751377 AL602851 BM786353 BI012906 AW008952 M16234

AA132368 AI813806 AI582940 X16455 BQ319765 BM770005 BM836104 BX279781

highest scoring ESTs for CEACAM5:

AA053080 AA055606 AA126970 AA130584 AA132368 AA132490 AA132688 AA133927 AA134894 AA134921

Unigene Cluster for CEACAM5:

Carcinoembryonic antigen-related cell adhesion molecule 5

Hs.709196 [show with all ESTs]

Unigene Representative Sequence: NM_004363

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM5 (see all 9 )

ExUns:	1a	·	1b	^	2	^	3	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12a	·	12b	·	12c	·	12d
SP1:
SP2:							-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:
SP5:																																							-

About this scheme

ECgene alternative splicing isoforms for CEACAM5

3 Ensembl transcripts including schematic representations:

ENST00000378181 ENST00000221992 ENST00000405816

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CEACAM5 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CEACAM5

¹ / ² / ³

7 probe-sets matching CEACAM5 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1582_at²^{, 3}	U95-A	1	1.00	1.00	0.23	0.96	M29540	0.80	1.00	0.91	1
86583_at²^{, 3}	U95-E	2	1.00	0.94	0.80	1.40	AI583942	0.40	1.00	0.76	1
31442_at*²^{, 3}	U95-A	1	--	--	0.59	0.71	Z21818	0.20	1.00	0.72	1
201884_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004363	0.40	1.00	0.76	1
217291_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	Z21818	0.20	1.00	0.72	1
201884_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
217291_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks CEACAM5 for binary patterns associated with the probe-sets selected above

About GeneDecksing

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.709196
Expression variation in blood from EXPOLDB for CEACAM5
UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731
Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium
and fetal colon

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CEACAM5 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
zebrafish (Danio rerio)	ceacam1¹	--	carcinoembryonic antigen-related cell adhesion molecule more	42.78(n) 30.17(a)	114465 NM_001113794.1 NP_001107266.1

About this table Species with no ortholog for CEACAM5

ENSEMBL Gene Tree for CEACAM5

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for CEACAM5 gene

CEACAM6¹ ² CEACAM1¹ ² PSG5² PSG9² PSG8² PSG6² PSG11² CEACAM8²

CEACAM7² PSG3² PSG2² PSG7² PSG1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/146 NCBI SNPs in CEACAM5 are shown (see all 146 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 59)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7252828^1,2	A,C,F,H	46925680(+)	`tgtatG/Aacaga`	1	--	ut3¹		7	EA WA NA	512
	rs7249230^1,2	A,C,F,H	46913447(+)	`AGAACA/GAATTA`	1	K/E	mis¹		16	EA NA EU WA	1414
	rs11673394^1,2	A,C,F,H	46903147(+)	`AAGAAA/GCATAT`	1	--	ng5¹		12	EA NA EU WA	1048
	rs10423171^1,2	C,F,H	46916900(+)	`CTGGCC/AGCAAT`	1	S/R	mis¹ ese³		12	EU EA WA	1258
--	rs4803505^1,2	C,F,H	46926669(+)	`gctttC/Tcccaa`	1	--	ng3¹		7	EU EA WA NA	562
	rs7256221^1,2	C,F,H	46903715(+)	`AGGACT/AGTCAG`	1	--	ng5¹		7	NA EU EA WA	550
--	rs10407503^1,2	C,F,H	46913274(+)	`GGATGC/ATGTAG`	1	D/A	mis¹ ese³		8	EU EA WA	840
	rs11667651^1,2	C,F,H	46925846(+)	`ttaatC/Ttgaga`	1	--	ut3¹		3	EU EA	298
	rs882152^1,2	F,H	46902692(-)	`GCCGAG/AGTGAC`	1	--	ng5¹		4	EU EA WA	416
	rs3810152^1,2	F,H	46902652(+)	`CAGCCG/AGGCCC`	1	--	ng5¹		4	EU EA WA	412

About this table

HapMap Linkage Disequilibrium images for CEACAM5 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 114890

10/96 Novoseek disease relationships for CEACAM5 gene (see all 96 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
colorectal cancer	82.56	266	1293545 (7), 11898807 (5), 11289125 (5), 10770562 (4) (see all 99)
metastasis	79.99	407	11948229 (5), 14592671 (5), 10770562 (4), 16719189 (4) (see all 99)
colorectal carcinoma	79.82	95	8439497 (4), 12854170 (4), 11948229 (4), 10211983 (3) (see all 53)
adenocarcinoma	77.18	148	15082298 (5), 2328062 (4), 15337038 (4), 12521132 (3) (see all 91)
tumors	75.54	669	14981971 (6), 1290028 (6), 7914825 (5), 10858386 (5) (see all 99)
gastric cancer	71.63	126	8908563 (5), 8908719 (4), 1327687 (4), 9660027 (4) (see all 64)
nsclc	69.72	115	10808698 (5), 15363304 (5), 16809939 (4), 18646695 (4) (see all 51)
colon carcinoma	68.09	32	1477074 (2), 7688074 (2), 18375392 (2), 15510175 (2) (see all 20)
colon cancer	65.31	57	11964079 (4), 8141873 (3), 2314825 (3), 12636102 (3) (see all 29)
cancer	64.99	204	15017899 (9), 10601548 (4), 16223370 (3), 9704713 (3) (see all 99)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/939 PubMed articles for CEACAM5 gene (see all 939 ):

Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)^{3, 4} Ramachandran P....Loo J.A. (2006)
Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23. (PubMed id 10854848)^{3, 4} Boehm M.K. and Perkins S.J. (2000)
Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression. (PubMed id 2342461)^{3, 4} Schrewe H.... Zimmermann W. (1990)
Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. (PubMed id 3220478)^{3, 4} Barnett T.... Elting J.J. (1988)
Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure. (PubMed id 3033671)^{3, 4} Zimmermann W.... von Kleist S. (1987)
Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. (PubMed id 3670312)^{3, 4} Beauchemin N.... Stanners C.P. (1987)
Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. (PubMed id 3814146)^{3, 4} Oikawa S.... Kosaki G. (1987)
Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth. (PubMed id 11964079)^{1, 3} Wirth T....Juhl H. (2002)
Carcinoembryonic antigen messenger RNA expression in blood can predict relapse in gastric cancer. (PubMed id 17936797)^{1, 3} Ishigami S....Aikou T. (2008)
CEACAM5 and CEACAM6 are major target genes for Smad3-mediated TGF-beta signaling. (PubMed id 17653079)^{1, 3} Han S.U....Kim S.J. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1048	HGNC: 1817	AceView: CEACAM5	Ensembl:ENSG00000105388	euGenes: HUgn1048
ECgene: CEACAM5	H-InvDB: CEACAM5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for CEACAM5	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CEACAM5
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CEACAM5:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CEACAM5-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CEACAM5		Antibodies for CEACAM5
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CEACAM5		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (CEACAM5)
	Antibodies (CEACAM5)
	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for CEACAM5 (CEA)

	Recombinant Proteins (CEACAM 5 + 6, CD66c + CD66e, pan CEACAM, CD66a + CD66c + CD66d + CD66e, Carcino Embryonic Antigen CEA)
	Antibodies (CEACAM 5 + 6, CD66c + CD66e, pan CEACAM, CD66a + CD66c + CD66d + CD66e, Carcino Embryonic Antigen CEA)

Search OriGene for CEACAM5

Search Tocris compounds for CEACAM5

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for CEACAM5

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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CEACAM5 Gene at Home site.
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CEACAM5 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for CEACAM5

Summaries
for CEACAM5

Genomic Location
for CEACAM5

Proteins
for CEACAM5

Protein Domains/
Families
for CEACAM5

Gene Function
for CEACAM5

Pathways & Interactions
for CEACAM5

Drugs & Compounds
for CEACAM5

Transcripts
for CEACAM5

Expression
for CEACAM5

Orthologs
for CEACAM5

Paralogs
for CEACAM5

SNPs/Variants
for CEACAM5

Disorders & Mutations
for CEACAM5

Medical News
for CEACAM5

Publications
for CEACAM5

Search for CEACAM5

Genome Databases showing CEACAM5

Other Databases showing CEACAM5

Specialized Databases showing CEACAM5

Licensable Technologies
for CEACAM5

Services
for CEACAM5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CEACAM5 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor CEACAM5

Summariesfor CEACAM5

Genomic Locationfor CEACAM5

Proteinsfor CEACAM5

Protein Domains/Familiesfor CEACAM5

Gene Functionfor CEACAM5

Pathways & Interactionsfor CEACAM5

Drugs & Compoundsfor CEACAM5

Transcriptsfor CEACAM5

Expression for CEACAM5

Orthologsfor CEACAM5

Paralogsfor CEACAM5

SNPs/Variantsfor CEACAM5

Disorders & Mutationsfor CEACAM5

Medical Newsfor CEACAM5

Publicationsfor CEACAM5

Search for CEACAM5

Genome Databases showing CEACAM5

Other Databases showing CEACAM5

Specialized Databases showing CEACAM5

Licensable Technologiesfor CEACAM5

Servicesfor CEACAM5

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CEACAM5

Summaries
for CEACAM5

Genomic Location
for CEACAM5

Proteins
for CEACAM5

Protein Domains/
Families
for CEACAM5

Gene Function
for CEACAM5

Pathways & Interactions
for CEACAM5

Drugs & Compounds
for CEACAM5

Transcripts
for CEACAM5

Expression
for CEACAM5

Orthologs
for CEACAM5

Paralogs
for CEACAM5

SNPs/Variants
for CEACAM5

Disorders & Mutations
for CEACAM5

Medical News
for CEACAM5

Publications
for CEACAM5

Licensable Technologies
for CEACAM5

Services
for CEACAM5