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CEACAM5 Gene

protein-coding   GIFtS: 61
GCID: GC19P042212

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...


(Previous symbol: CEA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 51 2
CEA1 2 3 5
Meconium Antigen 1002 3
CD66e2
Carcinoembryonic Antigen3
CD66e Antigen3

External Ids:    HGNC: 18171   Entrez Gene: 10482   Ensembl: ENSG000001053887   OMIM: 1148905   UniProtKB: P067313   

Export aliases for CEACAM5 gene to outside databases

Previous GC identifers: GC19P042852 GC19P042604 GC19P046888 GC19P046904 GC19P038644


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEACAM5 Gene:
Members of the CEACAM subfamily, including CEACAM5, belong to the CEA gene family. For general information on the
CEA gene family, see CEACAM1 (MIM 109770).(supplied by OMIM, Oct 2009)

GeneCards Summary for CEACAM5 Gene:
CEACAM5 (carcinoembryonic antigen-related cell adhesion molecule 5) is a protein-coding gene. Diseases associated with CEACAM5 include urachal cancer, and gastric linitis plastica. GO annotations related to this gene include identical protein binding. An important paralog of this gene is PSG9.

UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731
Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor
for E.coli Dr adhesins

Gene Wiki entry for CEACAM5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CEACAM5 gene promoter:
         c-Fos   AP-1   NRSF form 1   NF-kappaB1   NF-kappaB   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM5 promoter sequence
   Search Chromatin IP Primers for CEACAM5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEACAM5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.1-q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.1-q13.2

CEACAM5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042212:  view genomic region     (about GC identifiers)

Start:
42,212,504 bp from pter      End:
42,234,437 bp from pter
Size:
21,934 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 5 precursor  
Size: 702 amino acids; 76795 Da
Subunit: Homodimer. Binding of E.coli Dr adhesins leads to dissociation of the homodimer
Sequence caution: Sequence=AAA62835.1; Type=Frameshift; Positions=359, 361;
4 PDB 3D structures from and Proteopedia for CEACAM5:
1E07 (3D)        2QSQ (3D)        2QST (3D)        2VER (3D)    
Secondary accessions: H9KVA7
Alternative splicing: 2 isoforms:  P06731-1   P06731-2   

Explore the universe of human proteins at neXtProt for CEACAM5: NX_P06731

Explore proteomics data for CEACAM5 at MOPED

Post-translational modifications: 

  • Complex immunoreactive glycoprotein with a MW of 180 kDa comprising 60% carbohydrate1
  • Glycosylation2 at Asn104, Asn115, Asn152, Asn182, Asn197, Asn204, Asn208, Asn246, Asn256, Asn274,
                                 Asn288, Asn292, Asn309, Asn330, Asn351, Asn360, Asn375, Asn432, Asn466, Asn480 (see all 28)

  • See CEACAM5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004354.2  
    ENSEMBL proteins: 
     ENSP00000381600   ENSP00000221992   ENSP00000385072   ENSP00000468997   ENSP00000473252  

    CEACAM5 Human Recombinant Protein Products:

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    Novus Biologicals CEACAM5 Protein
    Novus Biologicals CEACAM5 Lysate
    Sino Biological Recombinant Protein for CEACAM5
    Sino Biological Cell Lysate for CEACAM5
    ProSpec Recombinant Protein for CEACAM5
    Browse Proteins at Cloud-Clone Corp.

    CEACAM5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals CEACAM5 Antibodies
    Abcam antibodies for CEACAM5 (P06731, P40199, P13688)
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    ThermoFisher Antibody for CEACAM5
    LSBio Antibodies in human, mouse, rat for CEACAM5

    CEACAM5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry P06731

    ProtoNet protein and cluster: P06731

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 7 Ig-like (immunoglobulin-like) domains


    CEACAM5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEAM5_HUMAN, P06731
    Function: Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor
    for E.coli Dr adhesins

         Genatlas biochemistry entry for CEACAM5:
    carcinoembryonic antigen-related cell adhesion molecule 5

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0034235GPI anchor binding IMP10931872
    GO:0042802identical protein binding IPI10864933
    GO:0042803protein homodimerization activity IDA18086185
         
    CEACAM5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEACAM5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEACAM5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEACAM5

    miRNA
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    miRTarBase miRNAs that target CEACAM5:
    hsa-mir-335-5p (MIRT018234)

    Block miRNA regulation of human, mouse, rat CEACAM5 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CEACAM5
    SwitchGear 3'UTR luciferase reporter plasmidCEACAM5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEACAM5
    Predesigned siRNA for gene silencing in human, mouse, rat CEACAM5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEACAM5

    Clone
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    OriGene clones in human, mouse for CEACAM5 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEACAM5 (NM_004363)
    Sino Biological Human cDNA Clone for CEACAM5
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM5

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CEACAM5 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEAM5_HUMAN, P06731: Cell membrane; Lipid-anchor, GPI-anchor
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005887integral component of plasma membrane IDA10931872
    GO:0016323basolateral plasma membrane IDA15052268
    GO:0031225anchored component of membrane IEA--
    GO:0070062extracellular vesicular exosome IDA19056867
    GO:0071575integral component of external side of plasma membrane IDA10864933

    CEACAM5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEACAM5 About    
    See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling
    2Cell adhesion Cell matrix glycoconjugates
    Cell adhesion Cell matrix glycoconjugates
    3Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CEACAM5
        Lymphocyte Signaling
    Adhesion

    1 GeneGo (Thomson Reuters) Pathway for CEACAM5
        Cell adhesion Cell-matrix glycoconjugates




    CEACAM5 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CEACAM5: 
              Lung Cancer in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CEACAM5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CEACAM5 (P067311, 2, 3 ENSP000002219924) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTCHD2Q9P2K93, ENSP000002944844I2D: score=1 STRING: ENSP00000294484
    HNRNPMP522723, ENSP000003253764I2D: score=1 STRING: ENSP00000325376
    EWSR1Q018443, ENSP000003810314I2D: score=2 STRING: ENSP00000381031
    CEACAM5P067311EBI-3914938,EBI-3914938
    SELEENSP000003317364STRING: ENSP00000331736
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0010832negative regulation of myotube differentiation IDA10931872
    GO:0034109homotypic cell-cell adhesion IDA10864933
    GO:0043066negative regulation of apoptotic process IDA11448920
    GO:2000811negative regulation of anoikis IDA10910050

    CEACAM5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEACAM5 (CEAM5)

    1 DrugBank Compound for CEACAM5    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2,2,5,5-TETRAMETHYL-3-(SULFANYLMETHYL)-2,5-DIHYDRO-1H-PYRROL-1-OL-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for CEACAM5 gene (see all 58)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    labetuzumab 79.2 3 15592930 (2), 15809485 (1)
    b 723 65.2 21 8941003 (4), 10431845 (4), 7868083 (3), 1689123 (2) (see all 9)
    slex 49.3 19 17697728 (4), 11125284 (2), 11291879 (2), 12017332 (2) (see all 6)
    mucicarmine 47.9 1 10199475 (1)
    5fluorouracil 47.3 10 11943891 (1), 9538153 (1), 2314825 (1), 11448920 (1) (see all 7)
    leucovorin 44.2 3 18577244 (1), 15360055 (1), 12420861 (1)
    polynucleotide 39.5 9 7712333 (4), 9053029 (1), 7621253 (1), 8118800 (1)
    crcs 35.3 3 1962152 (2), 15221959 (1)
    irinotecan 33.2 4 20121626 (2), 16601395 (1)
    paraffin 29.3 11 12763211 (2), 2187320 (2), 1965432 (1), 11894632 (1) (see all 7)



    CEACAM5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CEACAM5 gene: 
    NM_004363.3  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000398599 ENST00000221992(uc010ehz.1 uc002orj.1 uc002orl.3)
    ENST00000460121 ENST00000596606 ENST00000405816 ENST00000595403 ENST00000595113

    miRNA
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    Block miRNA regulation of human, mouse, rat CEACAM5 using miScript Target Protectors
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CEACAM5
      QuantiTect SYBR Green Assays in human, mouse, rat CEACAM5
      QuantiFast Probe-based Assays in human, mouse, rat CEACAM5

    Selected AceView cDNA sequences (see all 574):

    BM751377 BM786353 AA055606 BM839383 BM769716 BM836104 AL602851 BQ319765 
    BM828560 X16455 BM850032 AW936877 BI012906 BM751729 BM836430 AW071196 
    AI640689 AI813806 AA132368 BX279781 AW008952 AL702861 BQ083565 BM770005 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM5 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c · 12d
    SP1:                                                                                                                                          
    SP2:                    -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                 
    SP3:                                                                                                                                          
    SP4:                                                                                                                                          
    SP5:                                                                                                                    -                     


    ECgene alternative splicing isoforms for CEACAM5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEACAM5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEACAM5 Expression
    About this image


    CEACAM5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Esophagus (Gastrointestinal Tract)
     
     Stomach (Gastrointestinal Tract)
    CEACAM5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEACAM5 Protein Expression

    UniProtKB/Swiss-Prot: CEAM5_HUMAN, P06731
    Tissue specificity: Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon

        Pathway & Disease-focused RT2 Profiler PCR Array including CEACAM5: 
              Lung Cancer in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CEACAM5
    OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CEACAM5
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    QuantiFast Probe-based Assays in human, mouse, rat CEACAM5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CEACAM5 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-264f5.61 si:ch211-264f5.6 44.03(n)
    32.35(a)
      100319064  XM_002665478.2  XP_002665524.2 
            Species with no ortholog for CEACAM5

    ENSEMBL Gene Tree for CEACAM5 (if available)
    TreeFam Gene Tree for CEACAM5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEACAM5 gene
    PSG92  PSG82  CEACAM42  PSG112  PSG32  CEACAM72  CEACAM212  PSG12  
    PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    Selected SIMAP similar genes for CEACAM5 using alignment to 6 protein entries:     CEAM5_HUMAN (see all proteins) (see all similar genes):
    CEACAM3    CEA    CEACAM6    CEACAM1    CEACAM8    CEACAM7
    DHFRP2    PSG    CEACAM4    PSG11    PSGII    PSG1
    PSG2    CEACAM21    PSG5    PSG8    PSG6    PSG4

    CEACAM5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEACAM5 (see all 657)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1138346801,2
    F--42210621(+) GGGCTC/TACCGA 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs104196071,2
    C,F,H--42210659(+) ACATGT/GGCATG 1 -- us2k15Minor allele frequency- G:0.01NS EA WA 536
    rs745164521,2
    C,F--42210733(+) CCCCAC/TTTCCC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1115021631,2
    C,F--42210785(+) GCCTCC/TCCAGG 1 -- us2k12Minor allele frequency- T:0.04CSA WA 120
    rs1886650341,2
    --42210802(+) TGACCA/TCCCTC 1 -- us2k10--------
    rs38101521,2
    C,F,H--42210812(+) CAGCCG/AGGCCC 1 -- us2k15Minor allele frequency- A:0.03NS EA 532
    rs72585241,2
    C,F,H--42210824(+) CAGCCC/TAGCAG 1 -- us2k110Minor allele frequency- T:0.15NS EA NA WA 538
    rs8821521,2
    C,F,H--42210852(-) GCCGAG/AGTGAC 1 -- us2k15Minor allele frequency- A:0.02NS EA WA 534
    rs1117128991,2
    C--42211005(+) CCCCCC/TCCTTC 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1493566381,2
    --42211045(+) GGGCAA/GCTCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEACAM5 (42212504 - 42234437 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CEACAM5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718577CNV Deletion23290073
    nsv522854CNV Gain19592680
    nsv482220CNV Gain20164927

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEACAM5
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 114890    OMIM disorders: --

    Selected diseases for CEACAM5 (see all 94):    
    About MalaCards
    urachal cancer    gastric linitis plastica    esophageal disease    urachal adenocarcinoma
    urethral diverticulum    linitis plastica    splenic infarction    pancreatic cystadenoma
    testicular sex cord-stromal tumor    arc syndrome    extragonadal germ cell tumor    warthin tumor
    secretory meningioma    primary peritoneal carcinoma    acinar cell carcinoma    peritoneal carcinoma
    malignant mesothelioma    peritonitis    adenomatoid tumor    gallbladder cancer

    1 disease from the University of Copenhagen DISEASES database for CEACAM5:
    Colorectal cancer

    CEACAM5 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CEACAM5 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colorectal cancer 83.2 287 1293545 (7), 11898807 (5), 11289125 (5), 20216474 (4) (see all 99)
    colorectal carcinoma 80.9 105 8439497 (4), 12854170 (4), 11948229 (4), 10211983 (3) (see all 56)
    metastasis 80.3 433 11948229 (5), 14592671 (5), 10770562 (4), 16719189 (4) (see all 99)
    adenocarcinoma 77.3 152 15082298 (5), 2328062 (4), 15337038 (4), 12521132 (3) (see all 93)
    tumors 75.8 729 14981971 (6), 1290028 (6), 7914825 (5), 10858386 (5) (see all 99)
    gastric cancer 72.2 138 19688060 (5), 8908563 (5), 8908719 (4), 9660027 (4) (see all 68)
    nsclc 70.8 138 10808698 (5), 15363304 (5), 16809939 (4), 18646695 (4) (see all 59)
    colon carcinoma 67.8 33 1477074 (2), 7688074 (2), 18375392 (2), 15510175 (2) (see all 21)
    colon cancer 65.8 58 11964079 (4), 8141873 (3), 2314825 (3), 12636102 (3) (see all 30)
    cancer 65.6 216 15017899 (9), 10601548 (4), 16223370 (3), 9704713 (3) (see all 99)


    Export disorders for CEACAM5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEACAM5 gene, integrated from 10 sources (see all 1056):
    (articles sorted by number of sources associating them with CEACAM5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation. (PubMed id 18086185)1, 2 Korotkova N.... Matthews S. (Mol. Microbiol. 2008)
    2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    3. Self recognition in the Ig superfamily. Identification of precise subdomains in carcinoembryonic antigen required for intercellular adhesion. (PubMed id 10864933)1, 2 Taheri M.... Stanners C.P. (J. Biol. Chem. 2000)
    4. Structural models for carcinoembryonic antigen and its complex with the single-chain Fv antibody molecule MFE23. (PubMed id 10854848)1, 2 Boehm M.K. and Perkins S.J. (FEBS Lett. 2000)
    5. Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type-specific expression. (PubMed id 2342461)1, 2 Schrewe H.... Zimmermann W. (Mol. Cell. Biol. 1990)
    6. Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. (PubMed id 3220478)1, 2 Barnett T.... Elting J.J. (Genomics 1988)
    7. Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. (PubMed id 3670312)1, 2 Beauchemin N.... Stanners C.P. (Mol. Cell. Biol. 1987)
    8. Primary structure of human carcinoembryonic antigen (CEA) deduced from cDNA sequence. (PubMed id 3814146)1, 2 Oikawa S.... Kosaki G. (Biochem. Biophys. Res. Commun. 1987)
    9. Isolation and characterization of cDNA clones encoding the human carcinoembryonic antigen reveal a highly conserved repeating structure. (PubMed id 3033671)1, 2 Zimmermann W.... von Kleist S. (Proc. Natl. Acad. Sci. U.S.A. 1987)
    10. Lead time of carcinoembryonic antigen elevation in the postoperative follow-up of colorectal cancer did not affect the survival rate after recurrence. (PubMed id 20162425)1, 9 Chen C.H....Wang J.Y. (Int J Colorectal Dis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1048 HGNC: 1817 AceView: CEACAM5 Ensembl:ENSG00000105388 euGenes: HUgn1048
    ECgene: CEACAM5 H-InvDB: CEACAM5

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CEACAM5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEACAM5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CEACAM5 gene:
    Search GeneIP for patents involving CEACAM5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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