CEACAM4 Gene
protein-coding GIFtS: 49
GCID: GC19M042125
|
|
carcinoembryonic antigen-related cell adhesion molecule...
(Previous symbol: CGM7)
| |
Aliases
for CEACAM4 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Carcinoembryonic Antigen-Related Cell Adhesion Molecule 41 2 | | NCA2 | | CGM71 2 3 | | Carcinoembryonic Antigen Gene Family Member 72 | | Carcinoembryonic Antigen CGM72 3 | | Nonspecific Cross-Reacting Antigen (NCA)2 | | Non-Specific Cross-Reacting Antigen W2362 3 | | Nonspecific Cross-Reacting Antigen W2362 | | CGM7_HUMAN2 | | |
| External Ids: | HGNC: 18161 | Entrez Gene: 10892 | Ensembl: ENSG000001053527 | UniProtKB: O758713 | | ORGUL members: | |
|---|
| NONCODE:n342385 | |
Export aliases for CEACAM4 gene to outside databasesPrevious GC identifers: GC19M042764 GC19M042517 GC19M046801 GC19M046817 GC19M038557
|---|
Summaries
for CEACAM4 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CEACAM4 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CEACAM4 gene promoter:
NRSF form 1 HSF1 (long) CUTL1 LCR-F1 NRSF form 2 POU2F1 POU2F1a HSF1short RSRFC4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEACAM4
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM4 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2CEACAM4 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M042125: view genomic region
(about GC identifiers)
Start:
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42,125,344 bp from pter |
End:
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42,133,442 bp from pter |
Size:
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8,099 bases |
Orientation:
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minus strand |
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Proteins
for CEACAM4 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEAM4_HUMAN, O75871 (See
protein sequence)Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 4 precursor Size: 244 amino acids; 25909 Da
Subcellular location: Membrane; Single-pass type I membrane protein
Secondary accessions: Q03715 Q7LDZ7Explore the universe of human proteins at neXtProt for CEACAM4: NX_O75871
Post-translational modifications:
N-glycosylated1
View neXtProt modification sites for NX_O75871
CEACAM4 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001808.2
ENSEMBL proteins: ENSP00000221954
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
CEACAM4 for ontologies About GeneDecksing
CEACAM4 Antibody Products:
Assay Products for CEACAM4: |
Protein
Domains /
Families
for CEACAM4 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CEACAM4 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O75871ProtoNet protein and cluster: O75871 1 Blocks protein family: IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: CEAM4_HUMAN, O75871Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain |
Function
for CEACAM4 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for CEACAM4:carcinoembryonic antigen-related cell adhesion molecule 4 (see CEA@)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: CEACAM4 (NM_001817) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM4 |
2 GenomeRNAi human phenotypes for CEACAM4:
|
Pathways & Interactions
for CEACAM4 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM4
|
Drugs & Compounds
for CEACAM4 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CEACAM4 for compounds About GeneDecksing
 Browse Tocris compounds for CEACAM4
2 Novoseek chemical compound relationships for CEACAM4 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| perchloric acid |
41.1 |
1 |
8395690 (1) |
| formaldehyde |
9.46 |
1 |
2371832 (1) |
Search CenterWatch for drugs/clinical trials and news about CEACAM4 / CEAM4
|
Transcripts
for CEACAM4 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEACAM4 gene: NM_001817.2 Unigene Cluster for CEACAM4: Carcinoembryonic antigen-related cell adhesion molecule 4 Hs.12 [show with all ESTs]Unigene Representative Sequence: NM_0018172 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000221954(uc002orh.1 uc010xwd.1) ENST00000472081
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM4
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM4
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CEACAM4 (NM_001817) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEACAM4 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM4 |
Additional cDNA sequence: AK298701.1 D90276.1 1 DOTS entry: DT.75161402 10 AceView cDNA sequences: BM727358 BV202329 BX644557 AI721225 BX644579 BM681735 AI242105 D90276 NM_001817 BF819374
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM4 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CEACAM4
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Expression
for CEACAM4 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEACAM4 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CEACAM4 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEACAM4
SOURCE GeneReport for Unigene cluster: Hs.12
UniProtKB/Swiss-Prot: CEAM4_HUMAN, O75871Tissue specificity: Granulocytes
SABiosciences Custom PCR Arrays for CEACAM4
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEACAM4
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CEACAM4 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM4 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM4 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM4 |
Orthologs
for CEACAM4 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CEACAM4 gene from 2/8 species (see all 8) About this table
ENSEMBL Gene Tree for CEACAM4 (if available)
TreeFam Gene Tree for CEACAM4 (if available) |
Paralogs
for CEACAM4 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CEACAM4 gene
- PSG92 PSG82 CEACAM52 PSG112 CEACAM72 PSG32 CEACAM212 PSG12
- PSG52 PSG62 CEACAM12 CEACAM82 PSG22 CEACAM62 CEACAM182 CEACAM162
- PSG42 CEACAM32
18/21 SIMAP similar genes for CEACAM4 using alignment to 2 protein entries: CEAM4_HUMAN (see all proteins)
(see all similar genes):CEACAM3 CEA CEACAM8 CEACAM6 CEACAM7 DHFRP2
SP1 PSG9 CEACAM1 DKFZp781M2392 PSG PSG11
PSG5 PSG1 CEACAM5 PSG2 PSG7 PSG4
CEACAM4 for paralogs About GeneDecksing
|
Genomic Variants
for CEACAM4 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEACAM4 (42125344 - 42133442 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CEACAM4
1 Indel: 45773 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEACAM4 |
|
Disorders
/ Diseases
for CEACAM4 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEACAM4 for disorders About GeneDecksing
20/22  diseases for CEACAM4 (see all 22): About MalaCardsmyeloid leukemia papillary thyroid carcinoma acute lymphoblastic leukemia chronic myeloid leukemia
lymphoblastic leukemia endometrial carcinoma colon carcinoma thyroid carcinoma
carcinoma papillary carcinoma colorectal adenoma and carcinoma colon cancer
adenoma colorectal cancer leukemia vaginitis
thyroiditis psoriasis breast cancer cervicitis
10/12 Novoseek disease relationships for CEACAM4 gene (see all 12) About this table
Export disorders for CEACAM4 gene to outside databases
|
Publications
for CEACAM4 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEACAM4 gene, integrated from 9 sources (see all 76):
(articles sorted by number of sources associating them with CEACAM4) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. (PubMed id 2050678)1, 2, 3, 9 Kuroki M....Matsuoka Y. (1991)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)
- Sequence and glycosylation site identity of two distinct glycoforms of nonspecific cross-reacting antigen as demonstrated by sequence analysis and fast atom bombardment mass spectrometry. (PubMed id 2341397)9 Hefta S.A....Shively J.E. (1990)
- Nonspecific cross-reacting antigen (NCA) expressed by human granulocytes: six species with different peptide sizes and membrane anchoring forms. (PubMed id 2154215)9 Kuroki M....Matsuoka Y. (1990)
- Prognostic significance of secondary cytogenetic changes and nonspecific cross-reacting antigen (NCA) in patients with Ph-positive chronic myeloid leukemia. (PubMed id 2332039)9 Haus O....Kotlarek-Haus S. (1990)
- [Nonspecific cross-reacting antigen (NCA)] (PubMed id 16149618)9 Hayashi T. and Imai K. (2005)
- A polymerase-chain-reaction assay for the specific identification of transcripts encoded by individual carcinoembryonic antigen (CEA)-gene-family members. (PubMed id 7690349)9 Thompson J....Zimmermann W. (1993)
- Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PubMed id 1427854)9 Khan W.N....Hammarstroem S. (1992)
- Behavior in immunoblotting of dimeric and monomeric f orms of nonspecific cross-reacting antigen (NCA-50) from normal lung. (PubMed id 1919023)9 Krop-Watorek A....Lisowska E. (1991)
|
External Searches for CEACAM4 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CEACAM4 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEACAM4 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEACAM4 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CEACAM4 gene:
Search GeneIP for patents involving CEACAM4
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEACAM4 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CEACAM4 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEACAM4 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEACAM4 | | | OriGene Protein Over-expression Lysate for CEACAM4 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CEACAM4 | | OriGene 3'-UTR Clone for CEACAM4 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM4 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM4 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CEACAM4 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CEACAM4 | | OriGene Custom Protein Services for CEACAM4 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | | Search Tocris compounds for CEACAM4 |
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 | | | CEACAM4 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM4 |
|  |  |  | | | | ThermoFisher Antibodies for CEACAM4 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM4 |
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