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Aliases for CEACAM4 Gene

Aliases for CEACAM4 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 4 2 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 4 2 5
  • Non-Specific Cross-Reacting Antigen W236 3 4
  • Carcinoembryonic Antigen CGM7 3 4
  • CGM7 3 4
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 4-Sv1 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 4-Sv2 3
  • Carcinoembryonic Antigen Gene Family Member 7 3
  • Nonspecific Cross-Reacting Antigen (NCA) 3
  • Nonspecific Cross-Reacting Antigen W236 3
  • CGM7_HUMAN 3
  • NCA 3

External Ids for CEACAM4 Gene

Previous HGNC Symbols for CEACAM4 Gene

  • CGM7

Previous GeneCards Identifiers for CEACAM4 Gene

  • GC19M042764
  • GC19M042517
  • GC19M046801
  • GC19M046817
  • GC19M042125
  • GC19M038557

Summaries for CEACAM4 Gene

GeneCards Summary for CEACAM4 Gene

CEACAM4 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 4) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

UniProtKB/Swiss-Prot for CEACAM4 Gene

  • Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM4 Gene

Genomics for CEACAM4 Gene

Regulatory Elements for CEACAM4 Gene

Enhancers for CEACAM4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEACAM4 on UCSC Golden Path with GeneCards custom track

Promoters for CEACAM4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEACAM4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM4 Gene

Chromosome:
19
Start:
41,616,986 bp from pter
End:
41,627,084 bp from pter
Size:
10,099 bases
Orientation:
Minus strand

Genomic View for CEACAM4 Gene

Genes around CEACAM4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM4 Gene

Proteins for CEACAM4 Gene

  • Protein details for CEACAM4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75871-CEAM4_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 4
    Protein Accession:
    O75871
    Secondary Accessions:
    • Q03715
    • Q7LDZ7

    Protein attributes for CEACAM4 Gene

    Size:
    244 amino acids
    Molecular mass:
    25909 Da
    Quaternary structure:
    • Interacts through its phosphorylated ITAM domain with the SH2 domain-containing cytoplasmic proteins involved in signaling processes during phagocytosis.
    Miscellaneous:
    • To study the function of the orphan receptor CEACAM4 chimeric proteins containing the extracellular bacteria-binding domain of CEACAM3 and the transmembrane and cytoplasmic part of CEACAM4 has been used.

neXtProt entry for CEACAM4 Gene

Proteomics data for CEACAM4 Gene at MOPED

Post-translational modifications for CEACAM4 Gene

  • N-glycosylated.
  • The cytoplasmic ITAM-like sequence becomes tyrosine phosphorylated by SRC family PTKs upon ligand-mediated receptor clustering and allows to initiate phagocytosis of bound ligand.
  • Glycosylation at Asn 57, Asn 104, Asn 111, and Asn 126
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM4 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CEACAM4 Gene

Domains & Families for CEACAM4 Gene

Protein Domains for CEACAM4 Gene

Suggested Antigen Peptide Sequences for CEACAM4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75871

UniProtKB/Swiss-Prot:

CEAM4_HUMAN :
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM4: view

Function for CEACAM4 Gene

Molecular function for CEACAM4 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 4 (see CEA@)
UniProtKB/Swiss-Prot Function:
Granulocyte orphan receptor that acts as an trigger efficient phagocytosis of attached particles.
genes like me logo Genes that share phenotypes with CEACAM4: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM4 Gene

Localization for CEACAM4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM4 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM4 Gene COMPARTMENTS Subcellular localization image for CEACAM4 gene
Compartment Confidence
plasma membrane 5
mitochondrion 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane TAS 2050678
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM4: view

Pathways & Interactions for CEACAM4 Gene

SuperPathways for CEACAM4 Gene

No Data Available

Interacting Proteins for CEACAM4 Gene

Gene Ontology (GO) - Biological Process for CEACAM4 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM4 Gene

Drugs & Compounds for CEACAM4 Gene

(1) Drugs for CEACAM4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CEACAM4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM4: view

Transcripts for CEACAM4 Gene

mRNA/cDNA for CEACAM4 Gene

(40) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEACAM4 Gene

Carcinoembryonic antigen-related cell adhesion molecule 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM4 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for CEACAM4 Gene

GeneLoc Exon Structure for
CEACAM4
ECgene alternative splicing isoforms for
CEACAM4

Expression for CEACAM4 Gene

mRNA expression in normal human tissues for CEACAM4 Gene

mRNA differential expression in normal tissues according to GTEx for CEACAM4 Gene

This gene is overexpressed in Whole Blood (x44.0) and Spleen (x4.1).

Protein differential expression in normal tissues from HIPED for CEACAM4 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CEACAM4 Gene



SOURCE GeneReport for Unigene cluster for CEACAM4 Gene Hs.12

mRNA Expression by UniProt/SwissProt for CEACAM4 Gene

O75871-CEAM4_HUMAN
Tissue specificity: Granulocytes.
genes like me logo Genes that share expression patterns with CEACAM4: view

Protein tissue co-expression partners for CEACAM4 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CEACAM4 Gene

Orthologs for CEACAM4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM4 35
  • 95.88 (n)
  • 94.24 (a)
CEACAM4 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ceacam10 35
  • 63.36 (n)
  • 46.81 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 15 (a)
OneToMany
CEACAM1 36
  • 19 (a)
OneToMany
CEACAM24 36
  • 32 (a)
OneToMany
CEACAM28 36
  • 12 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 8 (a)
OneToMany
-- 36
  • 3 (a)
OneToMany
-- 36
  • 2 (a)
OneToMany
-- 36
  • 2 (a)
OneToMany
-- 36
  • 4 (a)
OneToMany
-- 36
  • 3 (a)
OneToMany
-- 36
  • 4 (a)
OneToMany
-- 36
  • 3 (a)
OneToMany
-- 36
  • 5 (a)
OneToMany
-- 36
  • 5 (a)
OneToMany
-- 36
  • 6 (a)
OneToMany
-- 36
  • 5 (a)
OneToMany
-- 36
  • 6 (a)
OneToMany
-- 36
  • 8 (a)
OneToMany
-- 36
  • 8 (a)
OneToMany
-- 36
  • 7 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Ceacam13 36
  • 24 (a)
OneToMany
Ceacam5 36
  • 7 (a)
OneToMany
Psg17 36
  • 15 (a)
OneToMany
Psg19 36
  • 16 (a)
OneToMany
Psg20 36
  • 15 (a)
OneToMany
Psg29 36
  • 14 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia CEACAM4 36
  • 21 (a)
OneToOne
Species with no ortholog for CEACAM4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM4 Gene

ENSEMBL:
Gene Tree for CEACAM4 (if available)
TreeFam:
Gene Tree for CEACAM4 (if available)

Paralogs for CEACAM4 Gene

(21) SIMAP similar genes for CEACAM4 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CEACAM4: view

Variants for CEACAM4 Gene

Sequence variations from dbSNP and Humsavar for CEACAM4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1126454 - 41,625,940(-) TCTGG(C/G)ACCCG intron-variant, nc-transcript-variant, reference, missense
rs3848568 - 41,625,819(-) GCACA(A/G)GGGGA intron-variant, nc-transcript-variant, reference, missense
rs7507365 -- 41,622,851(+) acata(G/T)atata intron-variant
rs12983687 -- 41,617,173(+) GTCCA(C/T)GAACT downstream-variant-500B, utr-variant-3-prime
rs12983719 -- 41,617,217(+) ACCTC(C/T)GCTTT downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CEACAM4 Gene

Variant ID Type Subtype PubMed ID
nsv519408 CNV Gain 19592680
esv2718577 CNV Deletion 23290073
nsv2494 CNV Insertion 18451855
nsv522854 CNV Gain 19592680
esv2718578 CNV Deletion 23290073
esv2260460 CNV Deletion 18987734

Variation tolerance for CEACAM4 Gene

Residual Variation Intolerance Score: 87.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEACAM4 Gene

Disorders for CEACAM4 Gene

Relevant External Links for CEACAM4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM4

No disorders were found for CEACAM4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM4 Gene

Publications for CEACAM4 Gene

  1. Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. (PMID: 2050678) Kuroki M. … Matsuoka Y. (J. Biol. Chem. 1991) 2 3 4 23 67
  2. The granulocyte orphan receptor CEACAM4 is able to trigger phagocytosis of bacteria. (PMID: 25567962) Delgado TascA^n J. … Hauck C.R. (J. Leukoc. Biol. 2015) 3
  3. Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells. (PMID: 25152032) Wakabayashi-Nakao K. … Mochizuki T. (Biomed. Res. 2014) 3
  4. A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. (PMID: 19460752) Yeung M.L. … Jeang K.T. (J. Biol. Chem. 2009) 3
  5. Llama single-domain antibodies directed against nonconventional epitopes of tumor-associated carcinoembryonic antigen absent from nonspecific cross-reacting antigen. (PMID: 19531051) Behar G. … Baty D. (FEBS J. 2009) 23

Products for CEACAM4 Gene

Sources for CEACAM4 Gene

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