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Aliases for CEACAM3 Gene

Aliases for CEACAM3 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3 2 3
  • Carcinoembryonic Antigen CGM1 3 4
  • CD66d Antigen 3 4
  • CD66D 3 4
  • CGM1 3 4
  • Carcinoembryonic Antigen Gene Family Member 1 3
  • Nonspecific Cross-Reacting Antigen 3
  • W264 3
  • W282 3
  • CEA 3

External Ids for CEACAM3 Gene

Previous HGNC Symbols for CEACAM3 Gene

  • CGM1

Previous GeneCards Identifiers for CEACAM3 Gene

  • GC19P042940
  • GC19P042692
  • GC19P046976
  • GC19P046992
  • GC19P042300
  • GC19P038732

Summaries for CEACAM3 Gene

Entrez Gene Summary for CEACAM3 Gene

  • This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]

GeneCards Summary for CEACAM3 Gene

CEACAM3 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with CEACAM3 include gastric duplication cysts and pancreatic cystadenoma. An important paralog of this gene is CEACAM8.

UniProtKB/Swiss-Prot for CEACAM3 Gene

  • Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

Gene Wiki entry for CEACAM3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM3 Gene

Genomics for CEACAM3 Gene

Regulatory Elements for CEACAM3 Gene

Genomic Location for CEACAM3 Gene

Start:
41,796,437 bp from pter
End:
41,811,553 bp from pter
Size:
15,117 bases
Orientation:
Plus strand

Genomic View for CEACAM3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM3 Gene

Proteins for CEACAM3 Gene

  • Protein details for CEACAM3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40198-CEAM3_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 3
    Protein Accession:
    P40198
    Secondary Accessions:
    • G5E978
    • Q3KPH9

    Protein attributes for CEACAM3 Gene

    Size:
    252 amino acids
    Molecular mass:
    27091 Da
    Quaternary structure:
    • Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3 phosphorylation.

    Alternative splice isoforms for CEACAM3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM3 Gene

Proteomics data for CEACAM3 Gene at MOPED

Post-translational modifications for CEACAM3 Gene

  • Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to be detected.
  • Glycosylation at Asn104 and Asn111
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM3 Gene

No data available for DME Specific Peptides for CEACAM3 Gene

Domains for CEACAM3 Gene

Gene Families for CEACAM3 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CEACAM3 Gene

Suggested Antigen Peptide Sequences for CEACAM3 Gene

Graphical View of Domain Structure for InterPro Entry

P40198

UniProtKB/Swiss-Prot:

CEAM3_HUMAN :
  • P40198
Domain:
  • The cytosolic domain is involved in S100A9 interaction
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM3: view

Function for CEACAM3 Gene

Molecular function for CEACAM3 Gene

GENATLAS Biochemistry: carcinoembryonic antigen-related cell adhesion molecule 3 (see CEA@)
UniProtKB/Swiss-Prot Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.

miRNA for CEACAM3 Gene

miRTarBase miRNAs that target CEACAM3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEACAM3 Gene

Localization for CEACAM3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM3 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM3 Gene COMPARTMENTS Subcellular localization image for CEACAM3 gene
Compartment Confidence
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM3: view

Pathways for CEACAM3 Gene

SuperPathways for CEACAM3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEACAM3 Gene

None

No data available for Pathways by source for CEACAM3 Gene

Compounds for CEACAM3 Gene

(1) HMDB Compounds for CEACAM3 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(53) Novoseek inferred chemical compound relationships for CEACAM3 Gene

Compound -log(P) Hits PubMed IDs
b 723 81.4 52
arcitumomab 64.2 3
mucicarmine 62.5 4
5fluorouracil 37.4 19
paraffin 32.3 10
genes like me logo Genes that share compounds with CEACAM3: view

Transcripts for CEACAM3 Gene

mRNA/cDNA for CEACAM3 Gene

Unigene Clusters for CEACAM3 Gene

Carcinoembryonic antigen-related cell adhesion molecule 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM3 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for CEACAM3 Gene

GeneLoc Exon Structure for
CEACAM3
ECgene alternative splicing isoforms for
CEACAM3

Expression for CEACAM3 Gene

mRNA expression in normal human tissues for CEACAM3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM3 Gene

This gene is overexpressed in Whole Blood (47.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEACAM3 Gene

SOURCE GeneReport for Unigene cluster for CEACAM3 Gene Hs.11

mRNA Expression by UniProt/SwissProt for CEACAM3 Gene

P40198-CEAM3_HUMAN
Tissue specificity: CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney.
genes like me logo Genes that share expressions with CEACAM3: view

Orthologs for CEACAM3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM3 35
  • 97.88 (n)
  • 94.84 (a)
CEACAM3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 14 (a)
ManyToMany
CEACAM1 36
  • 22 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam3 16
Psg28 36
  • 15 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 4 (a)
ManyToMany
Species with no ortholog for CEACAM3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM3 Gene

ENSEMBL:
Gene Tree for CEACAM3 (if available)
TreeFam:
Gene Tree for CEACAM3 (if available)

Paralogs for CEACAM3 Gene

Pseudogenes.org Pseudogenes for CEACAM3 Gene

genes like me logo Genes that share paralogs with CEACAM3: view

Variants for CEACAM3 Gene

Sequence variations from dbSNP and Humsavar for CEACAM3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs734107 -- 41,809,883(-) GGGAA(A/C)CCCAT intron-variant
rs734108 -- 41,809,790(-) TTTAG(G/T)AACCC intron-variant
rs734109 -- 41,810,165(-) AAGCA(A/G)TTGGG intron-variant
rs899662 -- 41,811,243(+) CTTCC(G/T)CCAGG utr-variant-3-prime, nc-transcript-variant
rs1041999 - 41,796,696(+) CAGCC(C/T)CTCCC missense, reference, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM3 Gene

Variant ID Type Subtype PubMed ID
nsv522854 CNV Gain 19592680
esv2568775 CNV Deletion 19546169
esv2670061 CNV Deletion 23128226

Relevant External Links for CEACAM3 Gene

HapMap Linkage Disequilibrium report
CEACAM3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM3 Gene

Disorders for CEACAM3 Gene

(96) Novoseek inferred disease relationships for CEACAM3 Gene

Disease -log(P) Hits PubMed IDs
liver metastases 80.2 65
pancreatic cyst 71.7 6
tumors 70.3 205
colon carcinoma 69.3 25
colorectal carcinoma 69.1 37

Relevant External Links for CEACAM3

Genetic Association Database (GAD)
CEACAM3
Human Genome Epidemiology (HuGE) Navigator
CEACAM3
genes like me logo Genes that share disorders with CEACAM3: view

No data available for UniProtKB/Swiss-Prot for CEACAM3 Gene

Publications for CEACAM3 Gene

  1. Genomic organization, splice variants and expression of CGM1, a CD66- related member of the carcinoembryonic antigen gene family. (PMID: 8508798) Nagel G. … Zimmermann W.A. (Eur. J. Biochem. 1993) 3 4 23
  2. The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway. (PMID: 17506820) Sarantis H. … Gray-Owen S.D. (Cell. Microbiol. 2007) 3 23
  3. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PMID: 1427854) Khan W.N. … Hammarstroem S. (Genomics 1992) 3 4
  4. Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. (PMID: 2050678) Kuroki M. … Matsuoka Y. (J. Biol. Chem. 1991) 3 4
  5. The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes. (PMID: 11708798) Streichert T. … Bruemmer J. (Biochem. Biophys. Res. Commun. 2001) 3 4

Products for CEACAM3 Gene

Sources for CEACAM3 Gene

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