Aliases for CEACAM3 Gene
External Ids for CEACAM3 Gene
Previous HGNC Symbols for CEACAM3 Gene
Previous GeneCards Identifiers for CEACAM3 Gene
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]
GeneCards Summary for CEACAM3 Gene
CEACAM3 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 3) is a Protein Coding gene. Diseases associated with CEACAM3 include colorectal cancer and malignant pleural mesothelioma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. An important paralog of this gene is CEACAM8.
UniProtKB/Swiss-Prot for CEACAM3 Gene
Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen phagocytosis.