Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CEACAM3 Gene

protein-coding   GIFtS: 61
GCID: GC19P042300

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...


(Previous symbol: CGM1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 31 2     CEA2
CGM11 2 3     W2642
Carcinoembryonic Antigen CGM12 3     W2822
CD66D2 3     Carcinoembryonic Antigen Gene Family Member 12
CD66d Antigen2 3     Nonspecific Cross-Reacting Antigen2

External Ids:    HGNC: 18151   Entrez Gene: 10842   Ensembl: ENSG000001709567   OMIM: 6091425   UniProtKB: P401983   

Export aliases for CEACAM3 gene to outside databases

Previous GC identifers: GC19P042940 GC19P042692 GC19P046976 GC19P046992 GC19P038732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CEACAM3 Gene:
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs),
which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein
directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to
serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively
spliced transcript variants have been described. (provided by RefSeq, Mar 2013)

GeneCards Summary for CEACAM3 Gene:
CEACAM3 (carcinoembryonic antigen-related cell adhesion molecule 3) is a protein-coding gene. Diseases associated with CEACAM3 include gastric duplication cysts, and carcinoma showing thymus-like differentiation. An important paralog of this gene is PSG9.

UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198
Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of
CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important
role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of
pathogen phagocytosis

Gene Wiki entry for CEACAM3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEACAM3 gene promoter:
         Elk-1   FOXF2   NRSF form 1   GCNF   NRSF form 2   Nkx5-1   GATA-1   AREB6   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM3 promoter sequence
   Search Chromatin IP Primers for CEACAM3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEACAM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CEACAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042300:  view genomic region     (about GC identifiers)

Start:
42,300,369 bp from pter      End:
42,315,591 bp from pter
Size:
15,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 3 precursor  
Size: 252 amino acids; 27091 Da
Subunit: Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3
phosphorylation
Caution: This is not the ortholog of rat CEACAM3
Secondary accessions: Q3KPH9
Alternative splicing: 3 isoforms:  P40198-1   P40198-2   P40198-3   

Explore the universe of human proteins at neXtProt for CEACAM3: NX_P40198

Explore proteomics data for CEACAM3 at MOPED

Post-translational modifications: 

  • Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for
    phosphorylation to be detected1
  • Glycosylation2 at Asn104, Asn111
  • Modification sites at PhosphoSitePlus

  • See CEACAM3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001264092.1  NP_001806.2  

    ENSEMBL proteins: 
     ENSP00000349971   ENSP00000411641   ENSP00000341725   ENSP00000469333   ENSP00000221999  

    CEACAM3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CEACAM3
    OriGene Protein Over-expression Lysate for CEACAM3
    OriGene MassSpec for CEACAM3
    OriGene Custom Protein Services for CEACAM3
    GenScript Custom Purified and Recombinant Proteins Services for CEACAM3
    Novus Biologicals CEACAM3 Lysate
    Sino Biological Recombinant Protein for CEACAM3
    Sino Biological Cell Lysate for CEACAM3
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CEACAM3

    CEACAM3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CEACAM3 (CEACAM-3/CD66d)
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CEACAM3
    Novus Biologicals CEACAM3 Antibody
    Abcam antibodies for CEACAM3 (P13688, P40199, P40198)
    Cloud-Clone Corp. Antibodies for CEACAM3
    ThermoFisher Antibodies for CEACAM3
    LSBio Antibodies in human, mouse, rat for CEACAM3

    CEACAM3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CEACAM3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CEACAM3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CEACAM3
    Cloud-Clone Corp. CLIAs for CEACAM3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    CD: CD molecules
    VSET: Immunoglobulin superfamily / V-set domain containing

    3 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P40198

    ProtoNet protein and cluster: P40198

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198
    Domain: The cytosolic domain is involved in S100A9 interaction
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CEACAM3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEAM3_HUMAN, P40198
    Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of
    CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important
    role in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of
    pathogen phagocytosis

         Genatlas biochemistry entry for CEACAM3:
    carcinoembryonic antigen-related cell adhesion molecule 3 (see CEA@)

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEACAM3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEACAM3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEACAM3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEACAM3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CEACAM3:
    hsa-mir-335-5p (MIRT017197)

    Block miRNA regulation of human, mouse, rat CEACAM3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CEACAM3
    SwitchGear 3'UTR luciferase reporter plasmidCEACAM3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEACAM3
    Predesigned siRNA for gene silencing in human, mouse, rat CEACAM3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEACAM3

    Clone
    Products:
         
    OriGene clones in human, mouse for CEACAM3 (see all 6)
    OriGene ORF clones in mouse, rat for CEACAM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEACAM3 (NM_001815)
    Sino Biological Human cDNA Clone for CEACAM3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CEACAM3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CEACAM3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CEAM3_HUMAN, P40198: Membrane; Single-pass type I membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane2
    cytosol1
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    CEACAM3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEACAM3
    Interactions:

        GeneGlobe Interaction Network for CEACAM3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for CEACAM3 (P401983 ENSP000003499714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    CEACAM1P136883, ENSP000001615594I2D: score=2 STRING: ENSP00000161559
    SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
    SYKP434053I2D: score=1 
    CSNK1A1LENSP000003691264STRING: ENSP00000369126
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEACAM3 (CEAM3)

    1 HMDB Compound for CEACAM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    Selected Novoseek inferred chemical compound relationships for CEACAM3 gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 723 81.4 53 15971208 (5), 12883236 (5), 7684019 (4), 1696923 (4) (see all 22)
    arcitumomab 64.2 4 11085731 (2), 9990682 (1)
    mucicarmine 62.5 4 11710688 (3), 10405240 (1)
    5fluorouracil 37.4 25 8968385 (6), 15967383 (5), 11277324 (2), 12584740 (2) (see all 7)
    paraffin 32.3 15 7524376 (1), 7694788 (1), 1689137 (1), 2193875 (1) (see all 10)
    o-phenylenediamine 29.1 2 1385323 (1), 19377936 (1)
    hematoxylin 23.3 3 15888109 (1), 16330935 (1), 9070482 (1)
    18f fluorodeoxyglucose 21 1 12029557 (1)
    leucovorin 20.9 1 16115944 (1)
    gold 16.6 13 16797959 (2), 15790101 (2), 18976901 (1), 17963841 (1) (see all 8)



    CEACAM3 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CEACAM3 gene (2 alternative transcripts): 
    NM_001277163.2  NM_001815.4  

    Unigene Cluster for CEACAM3:

    Carcinoembryonic antigen-related cell adhesion molecule 3
    Hs.11  [show with all ESTs]
    Unigene Representative Sequence: AK298694
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357396(uc002orn.1) ENST00000595255 ENST00000599305 ENST00000415495(uc002oro.1)
    ENST00000344550 ENST00000596544 ENST00000599662 ENST00000221999(uc010eia.1)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CEACAM3 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CEACAM3
    SwitchGear 3'UTR luciferase reporter plasmidCEACAM3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CEACAM3
    Predesigned siRNA for gene silencing in human, mouse, rat CEACAM3
    Clone
    Products:
         
    OriGene clones in human, mouse for CEACAM3 (see all 6)
    OriGene ORF clones in mouse, rat for CEACAM3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CEACAM3 (NM_001815)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CEACAM3
      QuantiTect SYBR Green Assays in human, mouse, rat CEACAM3
      QuantiFast Probe-based Assays in human, mouse, rat CEACAM3

    Additional mRNA sequence: 

    AK298694.1 BC106728.1 D90277.1 L00692.1 L00693.1 

    9 DOTS entries:

    DT.408654  DT.97796755  DT.95076255  DT.100644978  DT.100035515  DT.100822611  DT.40105773  DT.75132501 
    DT.91652127 

    16 AceView cDNA sequences:

    D90277 BX409928 BX412166 BQ007154 BI031908 L00693 D90278 NM_001815 
    BQ335313 AU140869 AL597182 L00692 BF897514 BI022821 BF900392 BX458678 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                -                                             
    SP2:                                -     -                                       
    SP3:                                -     -           -                 -         
    SP4:                                                                              


    ECgene alternative splicing isoforms for CEACAM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CEACAM3 expression in normal human tissues (normalized intensities)      CEACAM3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AAGCCTGAGC
    CEACAM3 Expression
    About this image


    CEACAM3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Placenta (Extraembryonic Tissues)
    CEACAM3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEACAM3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.11

    UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198
    Tissue specificity: CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the
    granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus,
    ovary, placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney

        Custom PCR Arrays for CEACAM3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM3
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CEACAM3
    QuantiTect SYBR Green Assays in human, mouse, rat CEACAM3
    QuantiFast Probe-based Assays in human, mouse, rat CEACAM3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CEACAM3 gene from Selected species (see all 4)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ceacam35 carcinoembryonic antigen-related cell adhesion molecule more   --   7 (9.15 cM) 17150282 


    ENSEMBL Gene Tree for CEACAM3 (if available)
    TreeFam Gene Tree for CEACAM3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CEACAM3 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  
    PSG22  CEACAM162  PSG42  PSG72  
    Selected SIMAP similar genes for CEACAM3 using alignment to 4 protein entries:     CEAM3_HUMAN (see all proteins) (see all similar genes):
    CEA    CEACAM6    CEACAM1    CEACAM5    CEACAM7    CEACAM8
    CEACAM4    DKFZp781M2392    DHFRP2    PSG8    SP1    PSG5
    PSG7    PSG    PSG2    PSG4    PSG9    PSG1

    CEACAM3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CEACAM3
    PGOHUM00000234702


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CEACAM3 (see all 420)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456773161,2
    Cuntested142312900(+) GTGACC/TGGGGT 5 T syn10--------
    rs1452956091,2
    C--42298657(+) ACTGTG/TGTGTT 3 -- us2k10--------
    rs1476258761,2
    --42298806(+) TTATCA/GGTTGG 3 -- us2k10--------
    rs1929150481,2
    --42298925(+) TTCAAG/TTTGTG 3 -- us2k10--------
    rs1395627231,2
    --42299061(+) GGGCGC/TCCATA 3 -- us2k10--------
    rs1828013571,2
    C--42299132(+) ACACAA/CCCACA 3 -- us2k10--------
    rs739339051,2
    C,F--42299516(+) AGCCAC/TGTGAC 3 -- us2k13Minor allele frequency- T:0.09WA CSA 122
    rs1164765921,2
    F--42299517(+) GCCACG/ATGACT 3 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1879169091,2
    --42299590(+) AAGTTC/TATGTT 3 -- us2k10--------
    rs1497009871,2
    --42299617(+) CATTTA/CCAAAA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEACAM3 (42300369 - 42315591 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CEACAM3:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2568775CNV Deletion19546169
    esv2670061CNV Deletion23128226
    nsv522854CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEACAM3
    DNA2.0 Custom Variant and Variant Library Synthesis for CEACAM3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 609142    OMIM disorders: --

    Selected diseases for CEACAM3 (see all 111):    About MalaCards
    gastric duplication cysts    carcinoma showing thymus-like differentiation    bronchogenic cyst    pancreatic cystadenoma
    intestinal perforation    chondroid chordoma    parachordoma    cystadenoma
    cystadenocarcinoma    sarcomatoid mesothelioma    thymic carcinoma    malignant mesothelioma
    syringoma    prostate adenocarcinoma    gallbladder cancer    ovarian cyst
    granulosa cell tumor of the ovary    hemangioma of lung    polymorphous low-grade adenocarcinoma    collecting duct carcinoma


    CEACAM3 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CEACAM3 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver metastases 80.2 70 11391453 (5), 8067714 (5), 10424738 (4), 1419646 (2) (see all 43)
    pancreatic cyst 71.7 6 19152896 (1), 19249035 (1), 15282721 (1), 18775021 (1) (see all 6)
    tumors 70.3 447 2065334 (8), 8945616 (6), 15334630 (6), 12013118 (4) (see all 99)
    colon carcinoma 69.3 30 8689623 (2), 7629885 (1), 9028835 (1), 9564886 (1) (see all 24)
    colorectal carcinoma 69.1 41 8697997 (4), 1738240 (2), 7515172 (2), 15161680 (2) (see all 31)
    carcinoma 68.7 106 7515172 (3), 8693877 (3), 1718115 (3), 8123868 (3) (see all 76)
    colorectal cancer 68.7 97 11274010 (6), 12678536 (3), 11341176 (3), 12820382 (3) (see all 56)
    adenocarcinoma 67.5 118 7684019 (3), 11391453 (3), 11710688 (3), 1419646 (2) (see all 66)
    metastasis 63.4 116 12884096 (4), 12678536 (3), 16687080 (3), 10920938 (3) (see all 71)
    fowlpox 63.1 5 12384537 (1), 18483372 (1), 12738742 (1), 18039393 (1) (see all 5)

    Genetic Association Database (GAD): CEACAM3
    Human Genome Epidemiology (HuGE) Navigator: CEACAM3 (1 document)

    Export disorders for CEACAM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CEACAM3 gene, integrated from 10 sources (see all 870):
    (articles sorted by number of sources associating them with CEACAM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, splice variants and expression of CGM1, a CD66- related member of the carcinoembryonic antigen gene family. (PubMed id 8508798)1, 2, 9 Nagel G....Zimmermann W.A. (Eur. J. Biochem. 1993)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. (PubMed id 14707113)1, 2 Schmitter T.... Hauck C.R. (J. Exp. Med. 2004)
    4. Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. (PubMed id 12864848)1, 2 McCaw S.E.... Gray-Owen S.D. (Mol. Microbiol. 2003)
    5. The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes. (PubMed id 11708798)1, 2 Streichert T....Bruemmer J. (Biochem. Biophys. Res. Commun. 2001)
    6. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PubMed id 1427854)1, 2 Khan W.N....Hammarstroem S. (Genomics 1992)
    7. Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. (PubMed id 2050678)1, 2 Kuroki M....Matsuoka Y. (J. Biol. Chem. 1991)
    8. Hierarchical fine mapping of the cystic fibrosis modifier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6. (PubMed id 20047061)1, 9 Stanke F....TA1mmler B. (Hum. Genet. 2010)
    9. The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway. (PubMed id 17506820)1, 9 Sarantis H. and Gray-Owen S.D. (Cell. Microbiol. 2007)
    10. Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. (PubMed id 12571236)1, 9 Booth J.W....Gray-Owen S.D. (J. Biol. Chem. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1084 HGNC: 1815 AceView: CEACAM3 Ensembl:ENSG00000170956 euGenes: HUgn1084
    ECgene: CEACAM3 H-InvDB: CEACAM3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CEACAM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEACAM3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CEACAM3 gene:
    Search GeneIP for patents involving CEACAM3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Antibodies for CEACAM3 (CEACAM-3/CD66d)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for CEACAM3 (CEACAM-3/CD66d)   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CEACAM3  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for CEACAM3  
     OriGene MassSpec something-or-other for CEACAM3   OriGene clones in human, mouse for CEACAM3  
     OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM3   OriGene Purified Protein for CEACAM3  
     OriGene ORF clones in mouse, rat for CEACAM3   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CEACAM3   OriGene Custom Protein Services for CEACAM3  

     
     
     Block miRNA regulation of human, mouse, rat CEACAM3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CEACAM3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEACAM3 Predesigned siRNA for gene silencing in human, mouse, rat CEACAM3
     QuantiFast Probe-based Assays in human, mouse, rat CEACAM3 QuantiTect SYBR Green Assays in human, mouse, rat CEACAM3
     Custom PCR Arrays for CEACAM3 Search Chromatin IP Primers for CEACAM3
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CEACAM3  GeneGlobe Interaction Network for CEACAM3
     Regulatory tfbs in CEACAM3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CEACAM3 GenScript cDNA clones with any tag delivered in your preferred vector for CEACAM3
     GenScript Custom Assay Services for CEACAM3 GenScript Custom overexpressing Cell Line Services for CEACAM3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CEACAM3 (CEAM3)
     Proteins for CEACAM3
     Cell Lysates for CEACAM3
     cDNA Clones for CEACAM3
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CEACAM3 antibodies
     CEACAM3 lysates
     Antibodies for CEACAM3
     See all of Abcam's Antibodies, Kits and Proteins for CEACAM3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CEACAM3
     Antibodies for CEACAM3
     ELISAs for CEACAM3
     CLIAs for CEACAM3



     Browse ESI BIO Cell Lines and PureStem Progenitors for CEACAM3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM3
     SwitchGear 3'UTR luciferase reporter plasmids for CEACAM3
     SwitchGear Promoter luciferase reporter plasmids for CEACAM3
     ThermoFisher Antibodies for CEACAM3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEACAM3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEACAM3
     LSBio Antibodies in human, mouse, rat for CEACAM3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CEACAM3 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4