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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM3 Gene

protein-coding   GIFtS: 54
GCID: GC19P042300

carcinoembryonic antigen-related cell adhesion molecule...


(Previous symbol: CGM1)
 Explore 131 diseases affiliated with
CEACAM3 via our new
 Human Malady Compendium 
Biological research products
for CEACAM3
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 31 2     CEA2
CGM11 2 3     W2642
Carcinoembryonic Antigen CGM12 3     W2822
CD66D2 3     Carcinoembryonic Antigen Gene Family Member 12
CD66d Antigen2 3     Nonspecific Cross-Reacting Antigen2
CD66d1     

External Ids:    HGNC: 18151   Entrez Gene: 10842   Ensembl: ENSG000001709567   OMIM: 6091425   UniProtKB: P401983   

Export aliases for CEACAM3 gene to outside databases

Previous GC identifers: GC19P042940 GC19P042692 GC19P046976 GC19P046992 GC19P038732


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEACAM3:
This gene encodes a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which
are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs
phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an
important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript
variants have been described, but their biological validity has not been determined. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198
Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of
CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role
in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen
phagocytosis

Gene Wiki entry for CEACAM3


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM3 gene promoter:
         Elk-1   FOXF2   NRSF form 1   GCNF   NRSF form 2   Nkx5-1   GATA-1   AREB6   GCNF-1   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEACAM3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CEACAM3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042300:  view genomic region     (about GC identifiers)

Start:
42,300,369 bp from pter      End:
42,315,591 bp from pter
Size:
15,223 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 3 precursor  
Size: 252 amino acids; 27091 Da
Subunit: Interacts with S100A9/calprotectin. This interaction is calcium-dependent, but independent of CEACAM3
phosphorylation
Subcellular location: Membrane; Single-pass type I membrane protein
Caution: This is not the ortholog of rat CEACAM3
Secondary accessions: Q3KPH9
Alternative splicing: 3 isoforms:  P40198-1   P40198-2   P40198-3   

Explore the universe of human proteins at neXtProt for CEACAM3: NX_P40198

Post-translational modifications:

  • Tyrosine-phosphorylated in response to microbial binding. Tyr-230 and Tyr-241 are both required for phosphorylation to
  • be detected1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40198

  • CEACAM3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001806.2  
    ENSEMBL proteins: 
     ENSP00000349971   ENSP00000411641   ENSP00000341725   ENSP00000221999  

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    Uscn Proteins for CEACAM3

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    CEACAM3 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    CEACAM3 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P40198

    ProtoNet protein and cluster: P40198

    1 Blocks protein family: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198
    Domain: The cytosolic domain is involved in S100A9 interaction
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198
    Function: Major granulocyte receptor mediating recognition and efficient opsonin-independent phagocytosis of
    CEACAM-binding microorganisms, including Neissiria, Moxarella and Haemophilus species, thus playing an important role
    in the clearance of pathogens by the innate immune system. Responsible for RAC1 stimulation in the course of pathogen
    phagocytosis

         Genatlas biochemistry entry for CEACAM3:
    carcinoembryonic antigen-related cell adhesion molecule 3 (see CEA@)

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CEACAM3

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for CEACAM3 (P401983 ENSP000003499714) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    S100A8P051093, ENSP000003577214I2D: score=2 STRING: ENSP00000357721
    CEACAM1P136883, ENSP000001615594I2D: score=2 STRING: ENSP00000161559
    SRCP129313, ENSP000003509414I2D: score=2 STRING: ENSP00000350941
    SYKP434053I2D: score=1 
    CSNK1A1LENSP000003691264STRING: ENSP00000369126
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CEACAM3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEACAM3

    1 HMDB Compound for CEACAM3    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--
    10/53 Novoseek chemical compound relationships for CEACAM3 gene (see all 53)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    b 723 81.4 53 15971208 (5), 12883236 (5), 7684019 (4), 1696923 (4) (see all 22)
    arcitumomab 64.2 4 11085731 (2), 9990682 (1)
    mucicarmine 62.5 4 11710688 (3), 10405240 (1)
    5fluorouracil 37.4 25 8968385 (6), 15967383 (5), 11277324 (2), 12584740 (2) (see all 7)
    paraffin 32.3 15 7524376 (1), 7694788 (1), 1689137 (1), 2193875 (1) (see all 10)
    o-phenylenediamine 29.1 2 1385323 (1), 19377936 (1)
    hematoxylin 23.3 3 15888109 (1), 16330935 (1), 9070482 (1)
    18f fluorodeoxyglucose 21 1 12029557 (1)
    leucovorin 20.9 1 16115944 (1)
    gold 16.6 13 16797959 (2), 15790101 (2), 18976901 (1), 17963841 (1) (see all 8)

    Search CenterWatch for drugs/clinical trials and news about CEACAM3 / CEAM3 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEACAM3 gene: 
    NM_001815.2  

    Unigene Cluster for CEACAM3:

    Carcinoembryonic antigen-related cell adhesion molecule 3
    Hs.11  [show with all ESTs]
    Unigene Representative Sequence: AK298694
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000357396(uc002orn.1) ENST00000415495(uc002oro.1) ENST00000344550
    ENST00000221999(uc010eia.1)

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    Additional cDNA sequence: 

    AK298694.1 BC106728.1 D90277.1 L00692.1 L00693.1 

    9 DOTS entries:

    DT.408654  DT.97796755  DT.95076255  DT.100644978  DT.100035515  DT.100822611  DT.40105773  DT.75132501 
    DT.91652127 

    16 AceView cDNA sequences:

    L00692 D90278 AU140869 BI031908 D90277 BQ335313 BX412166 BX409928 
    L00693 AL597182 BQ007154 NM_001815 BF897514 BI022821 BF900392 BX458678 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM3    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                -                                             
    SP2:                                -     -                                       
    SP3:                                -     -           -                 -         
    SP4:                                                                              


    ECgene alternative splicing isoforms for CEACAM3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEACAM3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AAGCCTGAGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image
    See CEACAM3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEACAM3

    SOURCE GeneReport for Unigene cluster: Hs.11

    UniProtKB/Swiss-Prot: CEAM3_HUMAN, P40198
    Tissue specificity: CGM1a, the predominant CGM1 transcript, is granulocyte-specific. Not detected out of the
    granulocytic lineage, such as monocytes, lymphocytes, spleen, testis, colon, brain, liver, pancreas, thymus, ovary,
    placenta, skeletal muscle, prostate, small intestine, heart, lung and kidney

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEACAM3 gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    6(a)
    possible ortholog
    GL344292.1(1263-21096)
    zebrafish
    (Danio rerio)
    Actinopterygii si:dkey-250k15.96
    si:dkey-250k15.76
    (see all 9)
    si:dkey-250k15.7
    (see all 9)

    4(a)
    (see all 9)
    possible ortholog
    possible ortholog
    (see all 9)
    16(13402598-13403485)
    16(13433555-13459598)


    ENSEMBL Gene Tree for CEACAM3 (if available)
    TreeFam Gene Tree for CEACAM3 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEACAM3 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  CEACAM72  PSG32  CEACAM212  
    PSG12  PSG52  PSG62  CEACAM12  CEACAM82  PSG22  CEACAM62  CEACAM182  
    CEACAM162  PSG42  
    18/23 SIMAP similar genes for CEACAM3 using alignment to 4 protein entries:     CEAM3_HUMAN (see all proteins) (see all similar genes):
    CEA    CEACAM6    CEACAM5    CEACAM1    CEACAM8    CEACAM7
    CEACAM4    DKFZp781M2392    DHFRP2    PSG8    PSG9    SP1
    PSG5    PSG    PSG7    PSG2    PSG1    PSG4

    CEACAM3 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CEACAM3
    PGOHUM00000234702


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/336 NCBI SNPs in CEACAM3 are shown (see all 336    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1456773161,2
    C,other42312900(+) GTGACC/TGGGGT 2 T syn10--------
    rs1452956091,2
    --42298657(+) ACTGTG/TGTGTT 1 -- us2k10--------
    rs1476258761,2
    --42298806(+) TTATCA/GGTTGG 1 -- us2k10--------
    rs1929150481,2
    --42298925(+) TTCAAG/TTTGTG 1 -- us2k10--------
    rs1395627231,2
    --42299061(+) GGGCGC/TCCATA 1 -- us2k10--------
    rs1828013571,2
    --42299132(+) ACACAA/CCCACA 1 -- us2k10--------
    rs739339051,2
    C,F,--42299516(+) AGCCAC/TGTGAC 1 -- us2k13Minor allele frequency- T:0.09WA CSA 122
    rs1164765921,2
    --42299517(+) GCCACG/ATGACT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs1879169091,2
    --42299590(+) AAGTTC/TATGTT 1 -- us2k10--------
    rs1497009871,2
    --42299617(+) CATTTA/CCAAAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEACAM3 (42300369 - 42315591 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for CEACAM3
         1 CNV: 102845

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CEACAM3 for disorders           About GeneDecksing

    OMIM gene information: 609142    OMIM disorders: --

    20/131 diseases for CEACAM3 (see all 131):    About MalaCards
    polymorphous low-grade adenocarcinoma    pulmonary alveolar proteinosis    sertoli-leydig cell tumor    bile duct cancer
    gastric duplication cysts    chondroid chordoma    sclerosing cholangitis    ovarian sex cord tumors
    collecting duct carcinoma    leydig cell tumor    primary sclerosing cholangitis    intestinal perforation
    cystadenocarcinoma    malignant mesothelioma    pericardial effusion    malignant pleural mesothelioma
    cystadenoma    mucinous cystadenocarcinoma    giant cell tumor    carcinoma

    10/96 Novoseek disease relationships for CEACAM3 gene (see all 96)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    liver metastases 80.2 70 11391453 (5), 8067714 (5), 10424738 (4), 1419646 (2) (see all 43)
    pancreatic cyst 71.7 6 19152896 (1), 19249035 (1), 15282721 (1), 18775021 (1) (see all 6)
    tumors 70.3 447 2065334 (8), 8945616 (6), 15334630 (6), 12013118 (4) (see all 99)
    colon carcinoma 69.3 30 8689623 (2), 7629885 (1), 9028835 (1), 9564886 (1) (see all 24)
    colorectal carcinoma 69.1 41 8697997 (4), 1738240 (2), 7515172 (2), 15161680 (2) (see all 31)
    carcinoma 68.7 106 7515172 (3), 8693877 (3), 1718115 (3), 8123868 (3) (see all 76)
    colorectal cancer 68.7 97 11274010 (6), 12678536 (3), 11341176 (3), 12820382 (3) (see all 56)
    adenocarcinoma 67.5 118 7684019 (3), 11391453 (3), 11710688 (3), 1419646 (2) (see all 66)
    metastasis 63.4 116 12884096 (4), 12678536 (3), 16687080 (3), 10920938 (3) (see all 71)
    fowlpox 63.1 5 12384537 (1), 18483372 (1), 12738742 (1), 18039393 (1) (see all 5)

    Human Genome Epidemiology (HuGE) Navigator: CEACAM3 (1 document)

    Export disorders for CEACAM3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEACAM3 gene, integrated from 9 sources (see all 869):
    (articles sorted by number of sources associating them with CEACAM3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genomic organization, splice variants and expression of CGM1, a CD66- related member of the carcinoembryonic antigen gene family. (PubMed id 8508798)1, 2, 9 Nagel G....Zimmermann W.A. (1993)
    2. Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. (PubMed id 14707113)1, 2 Schmitter T.... Hauck C.R. (2004)
    3. Immunoreceptor tyrosine-based activation motif phosphorylation during engulfment of Neisseria gonorrhoeae by the neutrophil-restricted CEACAM3 (CD66d) receptor. (PubMed id 12864848)1, 2 McCaw S.E.... Gray-Owen S.D. (2003)
    4. The microbial receptor CEACAM3 is linked to the calprotectin complex in granulocytes. (PubMed id 11708798)1, 2 Streichert T....Bruemmer J. (2001)
    5. Identification of three new genes and estimation of the size of the carcinoembryonic antigen family. (PubMed id 1427854)1, 2 Khan W.N....Hammarstroem S. (1992)
    6. Molecular cloning of nonspecific cross-reacting antigens in human granulocytes. (PubMed id 2050678)1, 2 Kuroki M....Matsuoka Y. (1991)
    7. Hierarchical fine mapping of the cystic fibrosis modi fier locus on 19q13 identifies an association with two elements near the genes CEACAM3 and CEACAM6. (PubMed id 20047061)1, 9 Stanke F....TA1mmler B. (2010)
    8. The specific innate immune receptor CEACAM3 triggers neutrophil bactericidal activities via a Syk kinase-dependent pathway. (PubMed id 17506820)1, 9 Sarantis H. and Gray-Owen S.D. (2007)
    9. Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. (PubMed id 12571236)1, 9 Booth J.W....Gray-Owen S.D. (2003)
    10. CD66 identifies the biliary glycoprotein (BGP) adhesion molecule: cloning, expression, and adhesion functions of the BGPc splice variant. (PubMed id 8018919)1, 9 Watt S.M.... Simmons D.L. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1084 HGNC: 1815 AceView: CEACAM3 Ensembl:ENSG00000170956 euGenes: HUgn1084
    ECgene: CEACAM3 H-InvDB: CEACAM3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEACAM3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEACAM3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEACAM3 gene:
    Search GeneIP for patents involving CEACAM3

    GeneCards and IP:
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