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Aliases for CEACAM21 Gene

Aliases for CEACAM21 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 21 2 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21 2 5
  • R29124_1 3
  • CEACAM3 3

External Ids for CEACAM21 Gene

Previous GeneCards Identifiers for CEACAM21 Gene

  • GC19P046775
  • GC19P042041
  • GC19P038514
  • GC19P042055

Summaries for CEACAM21 Gene

GeneCards Summary for CEACAM21 Gene

CEACAM21 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 21) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM21 Gene

Genomics for CEACAM21 Gene

Regulatory Elements for CEACAM21 Gene

Enhancers for CEACAM21 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CEACAM21 on UCSC Golden Path with GeneCards custom track

Promoters for CEACAM21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEACAM21 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM21 Gene

Chromosome:
19
Start:
41,549,250 bp from pter
End:
41,586,844 bp from pter
Size:
37,595 bases
Orientation:
Plus strand

Genomic View for CEACAM21 Gene

Genes around CEACAM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM21 Gene

Proteins for CEACAM21 Gene

  • Protein details for CEACAM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KPI0-CEA21_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 21
    Protein Accession:
    Q3KPI0
    Secondary Accessions:
    • B7WNQ6
    • O75296
    • Q6UY47
    • Q96ER7

    Protein attributes for CEACAM21 Gene

    Size:
    293 amino acids
    Molecular mass:
    32373 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC34569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM21 Gene

Proteomics data for CEACAM21 Gene at MOPED

Post-translational modifications for CEACAM21 Gene

  • Glycosylation at Asn 111
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM21 Gene

No data available for DME Specific Peptides for CEACAM21 Gene

Domains & Families for CEACAM21 Gene

Protein Domains for CEACAM21 Gene

Suggested Antigen Peptide Sequences for CEACAM21 Gene

Graphical View of Domain Structure for InterPro Entry

Q3KPI0

UniProtKB/Swiss-Prot:

CEA21_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM21: view

Function for CEACAM21 Gene

genes like me logo Genes that share phenotypes with CEACAM21: view

Animal Model Products

miRNA for CEACAM21 Gene

miRTarBase miRNAs that target CEACAM21

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM21 Gene

Localization for CEACAM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM21 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM21 Gene COMPARTMENTS Subcellular localization image for CEACAM21 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CEACAM21 Gene

Pathways & Interactions for CEACAM21 Gene

SuperPathways for CEACAM21 Gene

No Data Available

Interacting Proteins for CEACAM21 Gene

Gene Ontology (GO) - Biological Process for CEACAM21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM21 Gene

Drugs & Compounds for CEACAM21 Gene

No Compound Related Data Available

Transcripts for CEACAM21 Gene

Unigene Clusters for CEACAM21 Gene

Carcinoembryonic antigen-related cell adhesion molecule 21:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM21 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for CEACAM21 Gene

GeneLoc Exon Structure for
CEACAM21
ECgene alternative splicing isoforms for
CEACAM21

Expression for CEACAM21 Gene

mRNA expression in normal human tissues for CEACAM21 Gene

mRNA differential expression in normal tissues according to GTEx for CEACAM21 Gene

This gene is overexpressed in Whole Blood (x21.5) and Spleen (x5.0).

SOURCE GeneReport for Unigene cluster for CEACAM21 Gene Hs.655885

genes like me logo Genes that share expression patterns with CEACAM21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CEACAM21 Gene

Orthologs for CEACAM21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEACAM1 36
  • 29 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 16 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg18 36
  • 15 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 23 (a)
ManyToMany
Species with no ortholog for CEACAM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM21 Gene

ENSEMBL:
Gene Tree for CEACAM21 (if available)
TreeFam:
Gene Tree for CEACAM21 (if available)

Paralogs for CEACAM21 Gene

(21) SIMAP similar genes for CEACAM21 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CEACAM21 Gene

genes like me logo Genes that share paralogs with CEACAM21: view

Variants for CEACAM21 Gene

Sequence variations from dbSNP and Humsavar for CEACAM21 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs714106 - 41,577,497(+) CTACA(A/C)CCTAC nc-transcript-variant, reference, missense, utr-variant-5-prime
rs2302188 - 41,579,520(+) ACCAT(A/G)TGCTC downstream-variant-500B, reference, missense
rs758349 -- 41,578,753(+) ACATT(C/T)CTTCC intron-variant
rs758350 -- 41,578,809(+) TCCCA(C/T)GGGAG intron-variant
rs7256883 -- 41,574,148(+) CATGC(A/G)AGATA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CEACAM21 Gene

Variant ID Type Subtype PubMed ID
dgv3880n71 CNV Loss 21882294
dgv3881n71 CNV Loss 21882294
nsv519408 CNV Gain 19592680
esv2718577 CNV Deletion 23290073

Variation tolerance for CEACAM21 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.44% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CEACAM21 Gene

Disorders for CEACAM21 Gene

Relevant External Links for CEACAM21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM21

No disorders were found for CEACAM21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM21 Gene

Publications for CEACAM21 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. (PMID: 23065704) Amin Al Olama A. … Eeles R.A. (Hum. Mol. Genet. 2013) 3
  5. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. (PMID: 21682944) Alkelai A. … Lerer B. (Int. J. Neuropsychopharmacol. 2012) 3

Products for CEACAM21 Gene

Sources for CEACAM21 Gene

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