CEACAM21 Gene
protein-coding GIFtS: 43
GCID: GC19P042041
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carcinoembryonic antigen-related cell adhesion molecule...
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Aliases
for CEACAM21 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carcinoembryonic Antigen-Related Cell Adhesion Molecule 211 2 | | R29124_11 2 | | FLJ135401 | | CEACAM32 |
Export aliases for CEACAM21 gene to outside databasesPrevious GC identifers: GC19P046775 GC19P038514 |
Summaries
for CEACAM21 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CEACAM21 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CEACAM21 gene promoter:
AREB6 PPAR-gamma1 AML1a NRSF form 1 PPAR-gamma2 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEACAM21
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM21 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2CEACAM21 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P042041: view genomic region
(about GC identifiers)
Start:
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42,041,702 bp from pter |
End:
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42,093,197 bp from pter |
Size:
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51,496 bases |
Orientation:
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plus strand |
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Proteins
for CEACAM21 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEA21_HUMAN, Q3KPI0 (See
protein sequence)Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 21 precursor Size: 293 amino acids; 32373 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAC34569.1; Type=Erroneous gene model prediction;
Secondary accessions: B7WNQ6 O75296 Q6UY47 Q96ER7Alternative splicing: 3 isoforms: Q3KPI0-1 Q3KPI0-2 Q3KPI0-3 Explore the universe of human proteins at neXtProt for CEACAM21: NX_Q3KPI0
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q3KPI0
CEACAM21 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001091976.1 NP_291021.2
ENSEMBL proteins: ENSP00000384380 ENSP00000390697 ENSP00000187608 ENSP00000385739
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
CEACAM21 for ontologies About GeneDecksing
CEACAM21 Antibody Products:
Assay Products for CEACAM21: |
Protein
Domains /
Families
for CEACAM21 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CEACAM21 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q3KPI0ProtoNet protein and cluster: Q3KPI0 2 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: CEA21_HUMAN, Q3KPI0Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Function
for CEACAM21 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM21 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM21 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): CEACAM21 (NM_001098506) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEACAM21 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM21 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM21 |
1 GenomeRNAi human phenotype for CEACAM21:
|
Pathways & Interactions
for CEACAM21 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM21
|
Drugs & Compounds
for CEACAM21 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEACAM21
Search CenterWatch for drugs/clinical trials and news about CEACAM21 / CEA21
|
Transcripts
for CEACAM21 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEACAM21 gene (2 alternative transcripts): NM_001098506.1 NM_033543.3 Unigene Cluster for CEACAM21: Carcinoembryonic antigen-related cell adhesion molecule 21 Hs.655885 [show with all ESTs]Unigene Representative Sequence: AK0236029 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000487420 ENST00000483481 ENST00000494375 ENST00000407170(uc002orc.1)
ENST00000461658 ENST00000482870 ENST00000457737(uc002orf.2 uc002org.4 uc002ore.4)
ENST00000187608 ENST00000401445
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM21 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM21 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CEACAM21 (NM_001098506) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEACAM21 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM21 |
Additional cDNA sequence: AK023602.1 AY358084.1 BC012001.1 BC106727.1 7 DOTS entries: DT.95364609 DT.97828808 DT.100748161 DT.100748166 DT.91754667 DT.121502767 DT.92414420 24/46 AceView cDNA sequences (see all 46): BM920293 CR614590 BI913326 BG534399 CD693965 BI833763 BM926504 AU137568 BF110434 BE672478 AY358084 CB529695 BC012001 BG254969 AX775927 BG393220 BX370751 CD520687 CD366377 NM_033543 BI833768 AK023602 BX372414 AI565085
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM21 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c |
|---|
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| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for CEACAM21
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Expression
for CEACAM21 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEACAM21 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAGCCTGAGC
About this image
See CEACAM21 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEACAM21
SOURCE GeneReport for Unigene cluster: Hs.655885
SABiosciences Custom PCR Arrays for CEACAM21
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEACAM21
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEACAM21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM21 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM21 |
Orthologs
for CEACAM21 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CEACAM21 gene from 2/4 species (see all 4) About this table
ENSEMBL Gene Tree for CEACAM21 (if available)
TreeFam Gene Tree for CEACAM21 (if available) |
Paralogs
for CEACAM21 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CEACAM21 gene
- PSG92 PSG82 CEACAM42 CEACAM52 PSG112 CEACAM72 PSG32 PSG12
- PSG52 PSG62 CEACAM12 CEACAM82 PSG22 CEACAM62 CEACAM182 CEACAM162
- PSG42 CEACAM32
18/21 SIMAP similar genes for CEACAM21 using alignment to 2 protein entries: CEA21_HUMAN (see all proteins)
(see all similar genes):CEA CEACAM6 CEACAM8 CEACAM1 PSG CEACAM5
CEACAM7 CEACAM3 PSG2 PSG3 PSG7 SP1
PSG8 PSG4 CEACAM16 PSG1 PSG9 PSG5
CEACAM21 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for CEACAM21
PGOHUM00000234703
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Genomic Variants
for CEACAM21 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEACAM21 (42041702 - 42093197 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CEACAM21: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEACAM21 |
|
Disorders
/ Diseases
for CEACAM21 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEACAM21 for disorders About GeneDecksing
1  disease for CEACAM21: About MalaCardsschizophrenia
Export disorders for CEACAM21 gene to outside databases
|
Publications
for CEACAM21 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEACAM21 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CEACAM21) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- DOCK4 and CEACAM21 as novel schizophrenia candidate g enes in the Jewish population. (PubMed id 21682944)1 Alkelai A....Lerer B. (2011)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for CEACAM21 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CEACAM21 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEACAM21 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEACAM21 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEACAM21 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CEACAM21 gene:
Search GeneIP for patents involving CEACAM21
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEACAM21 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CEACAM21 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEACAM21 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEACAM21 | | | OriGene Protein Over-expression Lysate for CEACAM21 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CEACAM21 | | OriGene 3'-UTR Clone for CEACAM21 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM21 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM21 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CEACAM21 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEACAM21 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM21 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEACAM21 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM21 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM21 |
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 | | | CEACAM21 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM21 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM21 |
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