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Aliases for CEACAM21 Gene

Aliases for CEACAM21 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 21 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21 2 3
  • R29124_1 3
  • CEACAM3 3

External Ids for CEACAM21 Gene

Previous GeneCards Identifiers for CEACAM21 Gene

  • GC19P046775
  • GC19P042041
  • GC19P038514
  • GC19P042055

Summaries for CEACAM21 Gene

GeneCards Summary for CEACAM21 Gene

CEACAM21 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 21) is a Protein Coding gene. An important paralog of this gene is CEACAM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM21 Gene

Genomics for CEACAM21 Gene

Regulatory Elements for CEACAM21 Gene

Enhancers for CEACAM21 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F041575 1 Ensembl ENCODE 33.8 +27.6 27551 2.4 CTCF CEBPG ZBTB40 TEAD3 ZNF121 POLR2A ELK1 ZNF263 SRF ZNF280D CEACAMP3 CEACAM21 ATP5SL ERICH4 EXOSC5 BCKDHA CEACAM5 CCDC97 CEACAM7 LINC01480
GH19F041547 0.9 ENCODE 28.5 +3.5 3477 10.5 HDGF HDAC1 TBP CBX3 PKNOX1 WRNIP1 ZNF335 ELK1 SCRT2 ETV6 CEACAMP3 CEACAM21 ATP5SL ERICH4 EXOSC5 BCKDHA LINC01480 ENSG00000268355 TMEM91 ENSG00000259436
GH19F041430 1.4 VISTA ENCODE 10.8 -117.4 -117449 2.4 HDGF ATF1 ZNF133 GLI4 RAD21 YY1 ZEB1 ZNF335 GLIS2 ZNF366 EXOSC5 SNRPA ENSG00000269843 ZNF526 B9D2 TGFB1 TMEM91 BCKDHA CCDC97 ITPKC
GH19F041438 1.1 ENCODE 11.1 -109.6 -109576 1.8 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 EXOSC5 CCDC97 ZNF526 SERTAD3 SNRPA ITPKC BCKDHA ZNF574 TGFB1 TMEM91
GH19F041542 1 Ensembl ENCODE 11.6 -6.7 -6729 1.0 HDAC1 CTCF IRF2 ZBTB40 RAD21 ZNF316 POLR2A ZBTB48 ZNF143 SMC3 ATP5SL ERICH4 CEACAM21 GC19M041536 LINC01480
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM21 on UCSC Golden Path with GeneCards custom track

Promoters for CEACAM21 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001817660 1850 3801 HDGF TBP PKNOX1 WRNIP1 ELK1 SCRT2 ETV6 CREM ZNF362 SMAD5

Genomic Location for CEACAM21 Gene

Chromosome:
19
Start:
41,549,250 bp from pter
End:
41,586,844 bp from pter
Size:
37,595 bases
Orientation:
Plus strand

Genomic View for CEACAM21 Gene

Genes around CEACAM21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM21 Gene

Proteins for CEACAM21 Gene

  • Protein details for CEACAM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KPI0-CEA21_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 21
    Protein Accession:
    Q3KPI0
    Secondary Accessions:
    • B7WNQ6
    • O75296
    • Q6UY47
    • Q96ER7

    Protein attributes for CEACAM21 Gene

    Size:
    293 amino acids
    Molecular mass:
    32373 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC34569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM21 Gene

Post-translational modifications for CEACAM21 Gene

  • Glycosylation at Asn 111
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CEACAM21 Gene

Domains & Families for CEACAM21 Gene

Suggested Antigen Peptide Sequences for CEACAM21 Gene

Graphical View of Domain Structure for InterPro Entry

Q3KPI0

UniProtKB/Swiss-Prot:

CEA21_HUMAN :
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM21: view

Function for CEACAM21 Gene

genes like me logo Genes that share phenotypes with CEACAM21: view

Animal Model Products

miRNA for CEACAM21 Gene

miRTarBase miRNAs that target CEACAM21

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM21 Gene

Localization for CEACAM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM21 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM21 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM21: view

Pathways & Interactions for CEACAM21 Gene

SuperPathways for CEACAM21 Gene

No Data Available

Interacting Proteins for CEACAM21 Gene

Gene Ontology (GO) - Biological Process for CEACAM21 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM21 Gene

Transcripts for CEACAM21 Gene

Unigene Clusters for CEACAM21 Gene

Carcinoembryonic antigen-related cell adhesion molecule 21:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM21 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for CEACAM21 Gene

GeneLoc Exon Structure for
CEACAM21
ECgene alternative splicing isoforms for
CEACAM21

Expression for CEACAM21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM21 Gene

mRNA differential expression in normal tissues according to GTEx for CEACAM21 Gene

This gene is overexpressed in Whole Blood (x21.5) and Spleen (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of CEACAM21 Gene:

CEACAM21

SOURCE GeneReport for Unigene cluster for CEACAM21 Gene:

Hs.655885
genes like me logo Genes that share expression patterns with CEACAM21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CEACAM21 Gene

Orthologs for CEACAM21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM21 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEACAM1 35
  • 29 (a)
ManyToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 23 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 16 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg18 35
  • 15 (a)
ManyToMany
Species where no ortholog for CEACAM21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM21 Gene

ENSEMBL:
Gene Tree for CEACAM21 (if available)
TreeFam:
Gene Tree for CEACAM21 (if available)

Paralogs for CEACAM21 Gene

(21) SIMAP similar genes for CEACAM21 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CEACAM21 Gene

genes like me logo Genes that share paralogs with CEACAM21: view

Variants for CEACAM21 Gene

Sequence variations from dbSNP and Humsavar for CEACAM21 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10153482 -- 41,551,536(+) CTCAA(C/T)ATGGA intron-variant
rs10405039 -- 41,562,801(+) tcggc(G/T)cagtg intron-variant, upstream-variant-2KB
rs10405042 -- 41,586,173(+) CACCA(A/G)GGCAG intron-variant, utr-variant-3-prime
rs10406221 -- 41,572,251(+) TTGCA(A/G)TGATG intron-variant, utr-variant-5-prime
rs10407214 -- 41,559,713(+) AGACA(A/C)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM21 Gene

Variant ID Type Subtype PubMed ID
nsv579603 CNV loss 21841781
nsv519408 CNV gain 19592680
nsv442463 CNV loss 18776908
nsv1055515 CNV loss 25217958
esv3644387 CNV loss 21293372
esv3583419 CNV loss 25503493
esv3556412 CNV deletion 23714750
esv2718577 CNV deletion 23290073
esv2668558 CNV deletion 23128226
dgv6456n54 CNV loss 21841781
dgv6455n54 CNV loss 21841781
dgv3549n100 CNV gain 25217958

Variation tolerance for CEACAM21 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.66; 78.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM21

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM21 Gene

Disorders for CEACAM21 Gene

Relevant External Links for CEACAM21

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM21

No disorders were found for CEACAM21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM21 Gene

Publications for CEACAM21 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. (PMID: 23065704) Amin Al Olama A. … Eeles R.A. (Hum. Mol. Genet. 2013) 3 64
  5. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. (PMID: 21682944) Alkelai A. … Lerer B. (Int. J. Neuropsychopharmacol. 2012) 3 64

Products for CEACAM21 Gene

Sources for CEACAM21 Gene

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