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Aliases for CEACAM21 Gene

Aliases for CEACAM21 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21 2 3
  • R29124_1 3
  • CEACAM3 3

External Ids for CEACAM21 Gene

Summaries for CEACAM21 Gene

GeneCards Summary for CEACAM21 Gene

CEACAM21 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 21) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM21 Gene

Genomics for CEACAM21 Gene

Genomic Location for CEACAM21 Gene

Start:
41,549,518 bp from pter
End:
41,586,844 bp from pter
Size:
37,327 bases
Orientation:
Plus strand

Genomic View for CEACAM21 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM21 Gene

Regulatory Elements for CEACAM21 Gene

Proteins for CEACAM21 Gene

  • Protein details for CEACAM21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KPI0-CEA21_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 21
    Protein Accession:
    Q3KPI0
    Secondary Accessions:
    • B7WNQ6
    • O75296
    • Q6UY47
    • Q96ER7

    Protein attributes for CEACAM21 Gene

    Size:
    293 amino acids
    Molecular mass:
    32373 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC34569.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM21 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM21 Gene

Proteomics data for CEACAM21 Gene at MOPED

Post-translational modifications for CEACAM21 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn111

Other Protein References for CEACAM21 Gene

No data available for DME Specific Peptides for CEACAM21 Gene

Domains for CEACAM21 Gene

Gene Families for CEACAM21 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for CEACAM21 Gene

UniProtKB/Swiss-Prot:

CEA21_HUMAN
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.:
    • Q3KPI0
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.:
    • Q3KPI0
genes like me logo Genes that share domains with CEACAM21: view

Function for CEACAM21 Gene

Gene Ontology (GO) - Molecular Function for CEACAM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CEACAM21: view

Phenotypes for CEACAM21 Gene

GenomeRNAi human phenotypes for CEACAM21:
genes like me logo Genes that share phenotypes with CEACAM21: view

miRNA for CEACAM21 Gene

miRTarBase miRNAs that target CEACAM21

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for CEACAM21 Gene

Localization for CEACAM21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM21 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM21 Gene COMPARTMENTS Subcellular localization image for CEACAM21 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM21: view

Pathways for CEACAM21 Gene

SuperPathways for CEACAM21 Gene

No Data Available

Interacting Proteins for CEACAM21 Gene

Gene Ontology (GO) - Biological Process for CEACAM21 Gene

None

No data available for Pathways by source for CEACAM21 Gene

Transcripts for CEACAM21 Gene

Unigene Clusters for CEACAM21 Gene

Carcinoembryonic antigen-related cell adhesion molecule 21:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM21 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c
SP1:
SP2: -

Relevant External Links for CEACAM21 Gene

GeneLoc Exon Structure for
CEACAM21
ECgene alternative splicing isoforms for
CEACAM21

Expression for CEACAM21 Gene

mRNA expression in normal human tissues for CEACAM21 Gene

mRNA differential expression in normal tissues according to GTEx for CEACAM21 Gene

This gene is overexpressed in Whole Blood (21.5) and Spleen (5.0).

SOURCE GeneReport for Unigene cluster for CEACAM21 Gene Hs.655885

genes like me logo Genes that share expressions with CEACAM21: view

Orthologs for CEACAM21 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM21 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 23 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CEACAM1 37
  • 29 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Psg18 37
  • 15 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 16 (a)
ManyToMany
Species with no ortholog for CEACAM21:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM21 Gene

ENSEMBL:
Gene Tree for CEACAM21 (if available)
TreeFam:
Gene Tree for CEACAM21 (if available)

Paralogs for CEACAM21 Gene

Selected SIMAP similar genes for CEACAM21 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for CEACAM21 Gene

genes like me logo Genes that share paralogs with CEACAM21: view

Variants for CEACAM21 Gene

Sequence variations from dbSNP and Humsavar for CEACAM21 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs714106 - 41,577,497(+) CTACA(A/C)CCTAC reference, missense, utr-variant-5-prime
rs723902 -- 41,577,830(+) ACCCC(C/G)CTTGG intron-variant
rs740591 -- 41,578,234(+) CTCAG(A/G)AGGAG intron-variant
rs758349 -- 41,578,753(+) ACATT(C/T)CTTCC intron-variant
rs758350 -- 41,578,809(+) TCCCA(C/T)GGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM21 Gene

Variant ID Type Subtype PubMed ID
dgv3880n71 CNV Loss 21882294
dgv3881n71 CNV Loss 21882294
nsv519408 CNV Gain 19592680
esv2718577 CNV Deletion 23290073

Relevant External Links for CEACAM21 Gene

HapMap Linkage Disequilibrium report
CEACAM21

Disorders for CEACAM21 Gene

No disorders were found for CEACAM21 Gene.

No data available for UniProtKB/Swiss-Prot for CEACAM21 Gene

Publications for CEACAM21 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. (PMID: 21682944) Alkelai A. … Lerer B. (Int. J. Neuropsychopharmacol. 2012) 3
  5. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. (PMID: 23065704) Amin Al Olama A. … Eeles R.A. (Hum. Mol. Genet. 2013) 3

Products for CEACAM21 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CEACAM21
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM21
    • Block miRNA regulation of CEACAM21 using miScript Target Protectors

    Sources for CEACAM21 Gene

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