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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM21 Gene

protein-coding   GIFtS: 45
GCID: GC19P042055

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 211 2
CEACAM32
R29124_12

External Ids:    HGNC: 288341   Entrez Gene: 902732   Ensembl: ENSG000000071297   UniProtKB: Q3KPI03   

Export aliases for CEACAM21 gene to outside databases

Previous GC identifers: GC19P046775 GC19P042041 GC19P038514


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEACAM21 Gene: 
CEACAM21 (carcinoembryonic antigen-related cell adhesion molecule 21) is a protein-coding gene. Diseases associated with CEACAM21 include schizophrenia. An important paralog of this gene is PSG9.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM21 gene promoter:
         AREB6   PPAR-gamma1   AML1a   NRSF form 1   PPAR-gamma2   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM21 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEACAM21

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM21


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CEACAM21 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM21 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P042055:  view genomic region     (about GC identifiers)

Start:
42,055,886 bp from pter      End:
42,093,197 bp from pter
Size:
37,312 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEA21_HUMAN, Q3KPI0 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 21 precursor  
Size: 293 amino acids; 32373 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAC34569.1; Type=Erroneous gene model prediction;
Secondary accessions: B7WNQ6 O75296 Q6UY47 Q96ER7
Alternative splicing: 3 isoforms:  Q3KPI0-1   Q3KPI0-2   Q3KPI0-3   

Explore the universe of human proteins at neXtProt for CEACAM21: NX_Q3KPI0

Explore proteomics data for CEACAM21 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q3KPI0

  • CEACAM21 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEACAM21 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001091976.1  NP_291021.2  

    ENSEMBL proteins: 
     ENSP00000384380   ENSP00000390697   ENSP00000187608   ENSP00000385739  

    Human Recombinant Protein Products for CEACAM21: 
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    Cloud-Clone Corp. Proteins for CEACAM21 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CEACAM21 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q3KPI0

    ProtoNet protein and cluster: Q3KPI0

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CEA21_HUMAN, Q3KPI0
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    CEACAM21 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CEACAM21 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CEACAM21:
     Decreased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEACAM21 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM21


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM21

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEACAM21 (CEA21)

    Search CenterWatch for drugs/clinical trials and news about CEACAM21 / CEA21

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEACAM21 gene (2 alternative transcripts): 
    NM_001098506.1  NM_033543.3  

    Unigene Cluster for CEACAM21:

    Carcinoembryonic antigen-related cell adhesion molecule 21
    Hs.655885  [show with all ESTs]
    Unigene Representative Sequence: AK023602
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000461658 ENST00000407170(uc002orc.1) ENST00000482870 ENST00000457737(uc002orf.2 uc002org.4 uc002ore.4)
    ENST00000187608 ENST00000401445
    miRNA
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    Inhib. RNA
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                         Customized lentivirus expression plasmids for stable overexpression of CEACAM21 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM21
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM21

    Additional mRNA sequence: 

    AK023602.1 AY358084.1 BC012001.1 BC106727.1 

    7 DOTS entries:

    DT.95364609  DT.97828808  DT.100748161  DT.100748166  DT.91754667  DT.121502767  DT.92414420 

    24/46 AceView cDNA sequences (see all 46):

    CR614590 BM920293 AY358084 BM926504 BI913326 AK023602 BG534399 CD520687 
    BI833768 CD693965 BG254969 BC012001 BX370751 AX775927 BE672478 CD366377 
    BX372414 NM_033543 BG393220 BF110434 CB529695 AI565085 BI833763 AU137568 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM21    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for CEACAM21

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEACAM21 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAGCCTGAGC
    CEACAM21 Expression
    About this image


    See CEACAM21 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEACAM21

    SOURCE GeneReport for Unigene cluster: Hs.655885
        SABiosciences Custom PCR Arrays for CEACAM21
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM21

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEACAM21 gene from 2/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    8(a)
    possible ortholog
    GL344292.1(99-27567)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1983296
    si:ch211-264f5.66
    (see all 9)
    si:ch211-264f5.6
    (see all 9)
    9(a)
    6(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    16(13308875-13319736)
    19(6354742-6392621)
            Species with no ortholog for CEACAM21

    ENSEMBL Gene Tree for CEACAM21 (if available)
    TreeFam Gene Tree for CEACAM21 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEACAM21 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  PSG12  
    PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    18/21 SIMAP similar genes for CEACAM21 using alignment to 2 protein entries:     CEA21_HUMAN (see all proteins) (see all similar genes):
    CEA    CEACAM6    CEACAM8    CEACAM1    PSG    CEACAM5
    CEACAM7    CEACAM3    PSG4    PSG8    PSG2    PSG3
    PSG7    SP1    CEACAM16    PSG1    PSG5    PSG11

    CEACAM21 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CEACAM21
    PGOHUM00000234703


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/334 SNPs in CEACAM21 are shown (see all 334)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0346514
    ----see VAR_0346512 T N mis40--------
    VAR_0346524
    ----see VAR_0346522 M V mis40--------
    rs340938471,2
    C,F--42084656(+) AACTC-/T/TT  
            
    TTTTT
    2 -- int12NA 4
    rs72576921,2
    C,F,H--42268526(+) CTTAAT/AGATCT 2 -- us2k111Minor allele frequency- A:0.07NS EA NA WA 1312
    rs621194511,2
    C,F--42268542(+) TGGGCA/GATGGT 2 -- us2k12Minor allele frequency- G:0.16NA WA 120
    rs1146239421,2
    F--42268563(+) TGACAT/ACAAGA 2 -- us2k11Minor allele frequency- A:0.02WA 118
    rs1150165791,2
    F--42268641(+) GAACAC/TCATGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1897498791,2
    --42268649(+) TGAAGA/TAAGTG 2 -- us2k10--------
    rs1426327881,2
    --42268684(+) TTTTGA/CAAATC 2 -- us2k10--------
    rs1140411411,2
    F--42268698(+) TACCCC/TATAAG 2 -- us2k11Minor allele frequency- T:0.09WA 118

    HapMap Linkage Disequilibrium report for CEACAM21 (42055886 - 42093197 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CEACAM21:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718577CNV Deletion23290073
    dgv3881n71CNV Loss21882294
    dgv3880n71CNV Loss21882294
    nsv519408CNV Gain19592680

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CEACAM21:    About MalaCards
    schizophrenia    


    CEACAM21 for disorders           About GeneDecksing


    Export disorders for CEACAM21 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEACAM21 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CEACAM21)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    3. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non- aggressive disease. (PubMed id 23065704)1 Amin Al Olama A....Eeles R.A. (2013)
    4. DOCK4 and CEACAM21 as novel schizophrenia candidate g enes in the Jewish population. (PubMed id 21682944)1 Alkelai A....Lerer B. (2011)
    5. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90273 HGNC: 28834 AceView: R29124_1 Ensembl:ENSG00000007129 euGenes: HUgn90273
    ECgene: CEACAM21 H-InvDB: CEACAM21

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEACAM21 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEACAM21 gene:
    Search GeneIP for patents involving CEACAM21

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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