Aliases for CEACAM20 Gene
Aliases for CEACAM20 Gene
External Ids for CEACAM20 Gene
- HGNC: 24879
- Entrez Gene: 125931
- Ensembl: ENSG00000273777
- UniProtKB: Q6UY09
Previous GeneCards Identifiers for CEACAM20 Gene
- GC19M049698
- GC19M045005
- GC19M041442
Summaries for CEACAM20 Gene
GeneCards Summary for CEACAM20 Gene
CEACAM20 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 20) is a Protein Coding gene. An important paralog of this gene is CEACAM1.
UniProtKB/Swiss-Prot for CEACAM20 Gene
-
Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.
Additional gene information for CEACAM20 Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM20 Gene
Genomics for CEACAM20 Gene
GeneHancer (GH) Regulatory Elements for CEACAM20 Gene
GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
---|---|---|---|---|---|---|---|---|---|---|
GH19I044529 | Promoter | 0.6 | EPDnew | 550.8 | +0.3 | 320 | 0.1 | ZSCAN4 | CEACAM20 GC19M044519 |
- Top Transcription factor binding sites by QIAGEN in the CEACAM20 gene promoter:
Regulatory Element Products
Genomic Locations for CEACAM20 Gene
- chr19:44,501,677-44,529,945
- (GRCh38/hg38)
- Size:
- 28,269 bases
- Orientation:
- Minus strand
- chr19:45,005,729-45,033,811
- (GRCh37/hg19)
Genomic View for CEACAM20 Gene
- Cytogenetic band:
-
- 19q13.31 by Ensembl
- 19q13.31 by Entrez Gene
- 19q13.31 by HGNC


RefSeq DNA sequence for CEACAM20 Gene
Proteins for CEACAM20 Gene
-
Protein details for CEACAM20 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UY09-CEA20_HUMAN
- Recommended name:
- Carcinoembryonic antigen-related cell adhesion molecule 20
- Protein Accession:
- Q6UY09
Protein attributes for CEACAM20 Gene
- Size:
- 585 amino acids
- Molecular mass:
- 64502 Da
- Quaternary structure:
-
- Interacts (via extracellular domain) with PTPRH (via extracellular domain); the interaction dephosphorylates CEACAM20. Interacts (phosphorylated form) with SYK (via SH2 domains); the interaction further enhances CEACAM20 phosphorylation.
Post-translational modifications for CEACAM20 Gene
- Phosphorylated on tyrosine residues by SYK, SRC and FYN in vitro.
- Glycosylation at posLast=9696, posLast=105105, posLast=280280, Asn306, posLast=317317, posLast=368368, and posLast=415415
Other Protein References for CEACAM20 Gene
Antibody Products
-
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-
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Protein Products
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-
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Assay Products
No data available for DME Specific Peptides for CEACAM20 Gene
Domains & Families for CEACAM20 Gene
Gene Families for CEACAM20 Gene
Protein Domains for CEACAM20 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CEACAM20 Gene
- GenScript: Design optimal peptide antigens:
-
- Carcinoembryonic antigen-related cell adhesion molecule 20 variant 5L (A7LFK7_HUMAN)
- Carcinoembryonic antigen-related cell adhesion molecule 20 variant 4S (A7LFK8_HUMAN)
- Carcinoembryonic antigen-related cell adhesion molecule 20 variant 4L (A7LFK9_HUMAN)
- Carcinoembryonic antigen-related cell adhesion molecule 20 variant 5S (A7LFL0_HUMAN)
- Carcinoembryonic antigen-related cell adhesion molecule 20 (CEA20_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q6UY09- Family:
-
- Belongs to the immunoglobulin superfamily. CEA family.
Function for CEACAM20 Gene
Molecular function for CEACAM20 Gene
- UniProtKB/Swiss-Prot Function:
- Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.
Phenotypes for CEACAM20 Gene
- GenomeRNAi human phenotypes for CEACAM20:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for CEACAM20 gene
-
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- Search ViGene Biosciences for CEACAM20
CRISPR Products
-
OriGene CRISPR knockouts for CEACAM20
- genomics-online: gRNA clones - Search results for 80 available CEACAM20 gene related products
- Overview of 80 available CEACAM20 gene related products
- Applied Biological Materials CRISPR for CEACAM20
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEACAM20
- GenScript: Design CRISPR guide RNA sequences for CEACAM20
miRNA for CEACAM20 Gene
- miRTarBase miRNAs that target CEACAM20
miRNA Products
- Search ViGene Biosciences for CEACAM20
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEACAM20
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- Overview of 80 available CEACAM20 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CEACAM20 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CEACAM20
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CEACAM20
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CEACAM20 (CEACAM-20)
Cell Line Products
-
Horizon Cell Lines for CEACAM20
-
ViGene Biosciences adenoviral particle packaged cDNA for CEACAM20 gene
-
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No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM20 Gene
Localization for CEACAM20 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CEACAM20 Gene
- Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
GO:0016324 | apical plasma membrane | IEA | -- |
GO:0031528 | microvillus membrane | IEA | -- |
No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CEACAM20 Gene
Pathways & Interactions for CEACAM20 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002376 | immune system process | IEA | -- |
GO:0009617 | response to bacterium | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for CEACAM20 Gene
Transcripts for CEACAM20 Gene
mRNA/cDNA for CEACAM20 Gene
- (9) REFSEQ mRNAs :
- (2) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CEACAM20
- genomics-online: gRNA clones - Search results for 80 available CEACAM20 gene related products
- Overview of 80 available CEACAM20 gene related products
- Applied Biological Materials CRISPR for CEACAM20
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for CEACAM20
- GenScript: Design CRISPR guide RNA sequences for CEACAM20
miRNA Products
- Search ViGene Biosciences for CEACAM20
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for CEACAM20
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- genomics-online: shRNA clones - Search results for 80 available CEACAM20 gene related products
- Overview of 80 available CEACAM20 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for CEACAM20 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CEACAM20
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEACAM20
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for CEACAM20
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for CEACAM20 (CEACAM-20)
Expression for CEACAM20 Gene
mRNA differential expression in normal tissues according to GTEx for CEACAM20 Gene
NURSA nuclear receptor signaling pathways regulating expression of CEACAM20 Gene:
CEACAM20SOURCE GeneReport for Unigene cluster for CEACAM20 Gene:
Hs.689632Primer Products
-
OriGene qPCR primer pairs for CEACAM20
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM20 Gene
Orthologs for CEACAM20 Gene
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
dog (Canis familiaris) |
Mammalia | CEACAM20 33 |
|
||
cow (Bos Taurus) |
Mammalia | CEACAM20 33 |
|
||
rat (Rattus norvegicus) |
Mammalia | Ceacam20 33 |
|
||
mouse (Mus musculus) |
Mammalia | Ceacam20 33 16 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | zgc:198329 33 |
|
- Species where no ortholog for CEACAM20 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for CEACAM20 Gene
Paralogs for CEACAM20 Gene
(3) SIMAP similar genes for CEACAM20 Gene using alignment to 5 proteins:
Variants for CEACAM20 Gene
SNP ID | Clin | Chr 19 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000114362 | -- | 44,525,793(-) | G/T | genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
rs1000329894 | -- | 44,523,350(-) | A/G | intron_variant | |
rs1000387758 | -- | 44,529,256(-) | C/T | genic_upstream_transcript_variant, intron_variant | |
rs1000425027 | -- | 44,511,341(-) | G/A | 3_prime_UTR_variant, intron_variant | |
rs1000440087 | -- | 44,528,733(-) | T/C | genic_upstream_transcript_variant, intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3359491 | CNV | duplication | 20981092 |
nsv1061350 | CNV | loss | 25217958 |
nsv1146230 | CNV | insertion | 26484159 |
nsv472470 | CNV | novel sequence insertion | 20440878 |
Additional Variant Information for CEACAM20 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- CEACAM20
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CEACAM20 Gene
Disorders for CEACAM20 Gene
Additional Disease Information for CEACAM20
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for CEACAM20 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM20 Gene
Publications for CEACAM20 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
- Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis. (PMID: 23358633) Zhang H … Shively JE (PloS one 2013) 3 58
- Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PMID: 16139472) Zebhauser R … Zimmermann W (Genomics 2005) 3 58
- Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role. (PMID: 28659570) Daniwijaya EW … Matozaki T (The Kobe journal of medical sciences 2016) 3
Products for CEACAM20 Gene
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- Invitrogen Antibodies for CEACAM20
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CEACAM20
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneTex for Antibodies for CEACAM20
- Search GeneTex for Proteins for CEACAM20
- ViGene Biosciences adenoviral particle packaged cDNA for CEACAM20 gene
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- Overview of 80 available CEACAM20 gene related products
Sources for CEACAM20 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew