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CEACAM20 Gene(Protein Coding)

Carcinoembryonic Antigen Related Cell Adhesion Molecule 20

GCID:
GC19M044506
GIFtS:
30
Genes Participants
UDN Logo

Aliases for CEACAM20 Gene

Aliases for CEACAM20 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 20 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 20 2 3
  • GPAD9366 3
  • UNQ9366 3

External Ids for CEACAM20 Gene

Previous GeneCards Identifiers for CEACAM20 Gene

  • GC19M049698
  • GC19M045005
  • GC19M041442

Summaries for CEACAM20 Gene

GeneCards Summary for CEACAM20 Gene

CEACAM20 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 20) is a Protein Coding gene. An important paralog of this gene is CEACAM1.

UniProtKB/Swiss-Prot for CEACAM20 Gene

  • Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.

Additional gene information for CEACAM20 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM20 Gene

Genomics for CEACAM20 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for CEACAM20 Gene

Promoters and enhancers for CEACAM20 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19I044529 Promoter 0.6 EPDnew 550.8 +0.3 320 0.1 ZSCAN4 CEACAM20 GC19M044519
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CEACAM20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CEACAM20 gene promoter:

Genomic Locations for CEACAM20 Gene

Genomic Locations for CEACAM20 Gene
chr19:44,501,677-44,529,945
(GRCh38/hg38)
Size:
28,269 bases
Orientation:
Minus strand
chr19:45,005,729-45,033,811
(GRCh37/hg19)

Genomic View for CEACAM20 Gene

Genes around CEACAM20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM20 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CEACAM20 Gene

Proteins for CEACAM20 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CEACAM20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UY09-CEA20_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 20
    Protein Accession:
    Q6UY09

    Protein attributes for CEACAM20 Gene

    Size:
    585 amino acids
    Molecular mass:
    64502 Da
    Quaternary structure:
    • Interacts (via extracellular domain) with PTPRH (via extracellular domain); the interaction dephosphorylates CEACAM20. Interacts (phosphorylated form) with SYK (via SH2 domains); the interaction further enhances CEACAM20 phosphorylation.

neXtProt entry for CEACAM20 Gene

Post-translational modifications for CEACAM20 Gene

  • Phosphorylated on tyrosine residues by SYK, SRC and FYN in vitro.
  • Glycosylation at posLast=9696, posLast=105105, posLast=280280, Asn306, posLast=317317, posLast=368368, and posLast=415415

Other Protein References for CEACAM20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEACAM20 Gene

Domains & Families for CEACAM20 Gene

Gene Families for CEACAM20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for CEACAM20 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CEACAM20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UY09

UniProtKB/Swiss-Prot:

CEA20_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM20: view

Function for CEACAM20 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for CEACAM20 Gene

UniProtKB/Swiss-Prot Function:
Together with the tyrosine-protein kinase SYK, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response.
genes like me logo Genes that share phenotypes with CEACAM20: view

Animal Model Products

miRNA for CEACAM20 Gene

miRTarBase miRNAs that target CEACAM20

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM20 Gene

Localization for CEACAM20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM20 Gene

Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Colocalizes with PTPRH and CEACAM1 at the apical brush border of intestinal cells.

Gene Ontology (GO) - Cellular Components for CEACAM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016324 apical plasma membrane IEA --
GO:0031528 microvillus membrane IEA --
genes like me logo Genes that share ontologies with CEACAM20: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for CEACAM20 Gene

Pathways & Interactions for CEACAM20 Gene

SuperPathways for CEACAM20 Gene

PathCards logo More details on SuperPathways for CEACAM20
No Data Available

Interacting Proteins for CEACAM20 Gene

Selected Interacting proteins: Q6UY09-CEA20_HUMAN for CEACAM20 Gene via IID

Gene Ontology (GO) - Biological Process for CEACAM20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0009617 response to bacterium IEA --
genes like me logo Genes that share ontologies with CEACAM20: view

No data available for Pathways by source and SIGNOR curated interactions for CEACAM20 Gene

Drugs & Compounds for CEACAM20 Gene

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  1. Drug
No Compound Related Data Available

Transcripts for CEACAM20 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for CEACAM20 Gene

(9) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM20 Gene

No ASD Table

Relevant External Links for CEACAM20 Gene

GeneLoc Exon Structure for
CEACAM20
ECgene alternative splicing isoforms for
CEACAM20

Expression for CEACAM20 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM20 Gene

mRNA expression in normal human tissues for CEACAM20 Gene
mRNA expression by GTEx for CEACAM20 GenemRNA expression by BioGPS for CEACAM20 Gene

mRNA differential expression in normal tissues according to GTEx for CEACAM20 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x44.7) and Prostate (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CEACAM20 Gene:

CEACAM20

SOURCE GeneReport for Unigene cluster for CEACAM20 Gene:

Hs.689632
genes like me logo Genes that share expression patterns with CEACAM20: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM20 Gene

Orthologs for CEACAM20 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM20 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
 Mammalia CEACAM20 33
  • 75.03 (n)
cow
(Bos Taurus)
 Mammalia CEACAM20 33
  • 70.94 (n)
rat
(Rattus norvegicus)
 Mammalia Ceacam20 33
  • 68.9 (n)
mouse
(Mus musculus)
 Mammalia Ceacam20 33 16
  • 68.81 (n)
zebrafish
(Danio rerio)
 Actinopterygii zgc:198329 33
  • 43.37 (n)
Species where no ortholog for CEACAM20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEACAM20 Gene

ENSEMBL:
Gene Tree for CEACAM20 (if available)
TreeFam:
Gene Tree for CEACAM20 (if available)

Paralogs for CEACAM20 Gene

Paralogs for CEACAM20 Gene

(3) SIMAP similar genes for CEACAM20 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CEACAM20: view

Variants for CEACAM20 Gene

Sequence variations from dbSNP and Humsavar for CEACAM20 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000114362 -- 44,525,793(-) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000329894 -- 44,523,350(-) A/G intron_variant
rs1000387758 -- 44,529,256(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000425027 -- 44,511,341(-) G/A 3_prime_UTR_variant, intron_variant
rs1000440087 -- 44,528,733(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM20 Gene

Variant ID Type Subtype PubMed ID
esv3359491 CNV duplication 20981092
nsv1061350 CNV loss 25217958
nsv1146230 CNV insertion 26484159
nsv472470 CNV novel sequence insertion 20440878

Additional Variant Information for CEACAM20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for CEACAM20 Gene

Disorders for CEACAM20 Gene

Additional Disease Information for CEACAM20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for CEACAM20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM20 Gene

Publications for CEACAM20 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Role of CEACAM1 and CEACAM20 in an in vitro model of prostate morphogenesis. (PMID: 23358633) Zhang H … Shively JE (PloS one 2013) 3 58
  4. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PMID: 16139472) Zebhauser R … Zimmermann W (Genomics 2005) 3 58
  5. Tyrosine Phosphorylation of Carcinoembryonic Antigen-related Cell Adhesion Molecule 20 and Its Functional Role. (PMID: 28659570) Daniwijaya EW … Matozaki T (The Kobe journal of medical sciences 2016) 3

Products for CEACAM20 Gene

Sources for CEACAM20 Gene

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