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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM20 Gene

protein-coding   GIFtS: 37
GCID: GC19M045005

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...

  Search for CEACAM20
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 201 2
GPAD93662
UNQ93662

External Ids:    HGNC: 248791   Entrez Gene: 1259312   Ensembl: ENSG000001763957   UniProtKB: Q6UY093   

Export aliases for CEACAM20 gene to outside databases

Previous GC identifers: GC19M049698 GC19M041442


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEACAM20 Gene: 
CEACAM20 (carcinoembryonic antigen-related cell adhesion molecule 20) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM20 gene promoter:
         Bach1   COUP-TF1   ER-alpha   COUP   Pax-2   HNF-4alpha2   Pax-2a   Nkx5-1   HNF-4alpha1   COUP-TF   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CEACAM20

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM20


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

CEACAM20 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM20 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M045005:  view genomic region     (about GC identifiers)

Start:
45,005,729 bp from pter      End:
45,033,811 bp from pter
Size:
28,083 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEA20_HUMAN, Q6UY09 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 20 precursor  
Size: 585 amino acids; 64502 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Explore the universe of human proteins at neXtProt for CEACAM20: NX_Q6UY09

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UY09

  • CEACAM20 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (4 alternative transcripts): 
    NP_001096067.1  NP_001096068.1  NP_001096069.1  NP_001096070.1  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CEACAM20 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ISET: Immunoglobulin superfamily / I-set domain containing
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013098 Ig_I-set
     IPR013783 Ig-like_fold
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q6UY09

    ProtoNet protein and cluster: Q6UY09

    UniProtKB/Swiss-Prot: CEA20_HUMAN, Q6UY09
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains


    CEACAM20 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for CEACAM20:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEACAM20 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM20

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEACAM20 (CEA20)

    Search CenterWatch for drugs/clinical trials and news about CEACAM20 / CEA20

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEACAM20 gene (5 alternative transcripts): 
    NM_001102597.1  NM_198444.1  NM_001102598.1  NM_001102599.1  NM_001102600.1  

    Unigene Cluster for CEACAM20:

    Carcinoembryonic antigen-related cell adhesion molecule 20
    Hs.689632
    Unigene Representative Sequence: AY358129
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454753 ENST00000421432(uc010ejq.1) ENST00000448350 ENST00000431738
    ENST00000414638 ENST00000445209(uc010ejn.1) ENST00000412211(uc010ejo.1)
    ENST00000424903(uc010ejp.1) ENST00000316962
    miRNA
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    Additional mRNA sequence: 

    AY358129.1 EU008600.1 EU008601.1 EU008602.1 EU008603.1 

    2 AceView cDNA sequences:

    AY358129 NM_198444 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEACAM20 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEACAM20 Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.689632
        SABiosciences Custom PCR Arrays for CEACAM20
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM20

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CEACAM20 gene from 1/3 species (see all 3)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ceacam201 , 5 carcinoembryonic antigen-related cell adhesion molecule more1, 5 69.6(n)1
    58.35(a)1
      7 (9.96 cM)5
    716011  NM_027839.21  NP_082115.21 
     199654125 


    ENSEMBL Gene Tree for CEACAM20 (if available)
    TreeFam Gene Tree for CEACAM20 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEACAM20 gene
    3 SIMAP similar genes for CEACAM20 using alignment to 5 protein entries:     CEA20_HUMAN (see all proteins):
    CEACAM1    PSGII    PSG1

    CEACAM20 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/693 SNPs in CEACAM20 are shown (see all 693)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1494371351,2
    C--45009745(+) TCACTA/TCGTGT 4 -- ds50010--------
    rs769162831,2
    C,F--45009861(+) TACTCC/TTCTCT 4 -- ds50012Minor allele frequency- T:0.08NA EA 240
    rs1928685841,2
    --45009875(+) TGACTC/GAGACT 4 -- ds50010--------
    rs129819611,2
    C,F,H--45009977(+) TCTAAC/TTCTAG 4 -- ds500126Minor allele frequency- T:0.18NA NS EA 2686
    rs1438549921,2
    --45009991(+) CACGGC/GCTGTC 4 -- ds50010--------
    rs1403086561,2
    --45010005(+) TTTACC/GCTTAC 4 -- ds50010--------
    rs1853910041,2
    --45010021(+) CTTTGA/GAAAAA 4 -- ds50010--------
    rs133450321,2
    C,F,H--45010056(+) TATGGG/AAGCCA 4 -- ds500121Minor allele frequency- A:0.13NA NS EA WA 2482
    rs1442608411,2
    --45010105(+) CTACAA/GAGATG 4 -- ds50010--------
    rs14345771,2
    C,F,O,H--45010116(+) ACAGAG/TAATGA 4 -- ds500122Minor allele frequency- T:0.13NA NS EA 2440

    HapMap Linkage Disequilibrium report for CEACAM20 (45005729 - 45033811 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CEACAM20:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3944n71CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    CEACAM20 for disorders           About MalaCards

    CEACAM20 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CEACAM20
    Human Genome Epidemiology (HuGE) Navigator: CEACAM20 (1 document)

    Export disorders for CEACAM20 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEACAM20 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CEACAM20)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. Role of CEACAM1 and CEACAM20 in an in vitro model of p rostate morphogenesis. (PubMed id 23358633)1 Zhang H....Shively J.E. (2013)
    4. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PubMed id 16139472)1 Zebhauser R....Zimmermann W. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 125931 HGNC: 24879 AceView: UNQ9366 Ensembl:ENSG00000176395 euGenes: HUgn125931
    ECgene: CEACAM20 H-InvDB: CEACAM20

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEACAM20 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEACAM20 gene:
    Search GeneIP for patents involving CEACAM20

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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