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Aliases for CEACAM19 Gene

Aliases for CEACAM19 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 19 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 19 2 3
  • Carcinoembryonic Antigen-Like 1 3 4
  • CEAL1 3 4
  • CEACM19 3

External Ids for CEACAM19 Gene

Previous GeneCards Identifiers for CEACAM19 Gene

  • GC19P049870
  • GC19P045174
  • GC19P041606

Summaries for CEACAM19 Gene

GeneCards Summary for CEACAM19 Gene

CEACAM19 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 19) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM19 Gene

Genomics for CEACAM19 Gene

Regulatory Elements for CEACAM19 Gene

Enhancers for CEACAM19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G044633 1.6 Ensembl ENCODE dbSUPER 22.1 -22.9 -22881 11.1 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF263 PVR CEACAM19 ENSG00000252200 CEACAM22P
GH19G044586 2.1 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -72.1 -72089 8.1 CREB3L1 AGO1 ZFP64 DMAP1 FEZF1 YY1 ZNF143 ZNF548 ZNF263 SP3 ZNF225 ZNF180 ZNF45 ZNF155 ZNF224 ZNF234 ZNF284 ZNF230 LOC100505715 ENSG00000267114
GH19G044648 1.4 Ensembl ENCODE dbSUPER 15.9 -13.5 -13503 3.1 CBX3 NFIB AGO1 RAD21 SCRT2 PRPF4 EGR2 YY2 NFIC SMARCA4 PVR ZNF180 CEACAM19 ZNF155 ZNF45 ZNF224 ENSG00000266958 CEACAM22P MIR4531
GH19G044662 0.9 ENCODE dbSUPER 24.7 +0.5 513 1.5 MAZ L3MBTL2 AGO1 NR4A1 DMAP1 NR2F2 GATA3 SMARCA4 GATA2 ZNF341 CEACAM19 PVR ENSG00000279095
GH19G044676 1.2 Ensembl ENCODE 17.5 +15.2 15193 1.1 PKNOX1 SIN3A ZNF766 GATA2 FOS NFYC ZNF623 MEF2D SREBF1 SMARCA4 CEACAM19 IRGC GC19P044686 ENSG00000279095
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM19 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM19 Gene

Chromosome:
19
Start:
44,662,278 bp from pter
End:
44,684,359 bp from pter
Size:
22,082 bases
Orientation:
Plus strand

Genomic View for CEACAM19 Gene

Genes around CEACAM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM19 Gene

Proteins for CEACAM19 Gene

  • Protein details for CEACAM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z692-CEA19_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 19
    Protein Accession:
    Q7Z692
    Secondary Accessions:
    • Q5XJ15
    • Q7Z693

    Protein attributes for CEACAM19 Gene

    Size:
    300 amino acids
    Molecular mass:
    32638 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP70002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP70003.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM19 Gene

Post-translational modifications for CEACAM19 Gene

  • Glycosylation at Asn104
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM19 Gene

No data available for DME Specific Peptides for CEACAM19 Gene

Domains & Families for CEACAM19 Gene

Protein Domains for CEACAM19 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z692

UniProtKB/Swiss-Prot:

CEA19_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM19: view

Function for CEACAM19 Gene

Molecular function for CEACAM19 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated by dexamethasone (in vitro).

Gene Ontology (GO) - Molecular Function for CEACAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20374249
genes like me logo Genes that share ontologies with CEACAM19: view

Phenotypes for CEACAM19 Gene

genes like me logo Genes that share phenotypes with CEACAM19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CEACAM19

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM19 Gene

Localization for CEACAM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM19 gene
Compartment Confidence
plasma membrane 2
nucleus 2
extracellular 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM19: view

Pathways & Interactions for CEACAM19 Gene

SuperPathways for CEACAM19 Gene

No Data Available

Interacting Proteins for CEACAM19 Gene

Selected Interacting proteins: Q7Z692-CEA19_HUMAN for CEACAM19 Gene via IID

Symbol External ID(s) Details
BCL3

Gene Ontology (GO) - Biological Process for CEACAM19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM19 Gene

Transcripts for CEACAM19 Gene

Unigene Clusters for CEACAM19 Gene

Carcinoembryonic antigen-related cell adhesion molecule 19:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM19 Gene

No ASD Table

Relevant External Links for CEACAM19 Gene

GeneLoc Exon Structure for
CEACAM19
ECgene alternative splicing isoforms for
CEACAM19

Expression for CEACAM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM19 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEACAM19 Gene:

CEACAM19

SOURCE GeneReport for Unigene cluster for CEACAM19 Gene:

Hs.416925

mRNA Expression by UniProt/SwissProt for CEACAM19 Gene:

Q7Z692-CEA19_HUMAN
Tissue specificity: Ubiquitous with highest expression in prostate, uterus, fetal brain, mammary gland, adrenal gland, skeletal muscle, small intestine, and kidney, and lower expression in lung, cerebellum, testis, liver, pancreas, bone marrow and ovary.
genes like me logo Genes that share expression patterns with CEACAM19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM19 Gene

Orthologs for CEACAM19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM19 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia CEACAM19 34
  • 81.15 (n)
cow
(Bos Taurus)
Mammalia CEACAM19 34 35
  • 79.18 (n)
rat
(Rattus norvegicus)
Mammalia Ceacam19 34
  • 77.21 (n)
mouse
(Mus musculus)
Mammalia Ceacam19 34 16 35
  • 75.7 (n)
oppossum
(Monodelphis domestica)
Mammalia CEACAM19 35
  • 43 (a)
OneToOne
Species where no ortholog for CEACAM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM19 Gene

ENSEMBL:
Gene Tree for CEACAM19 (if available)
TreeFam:
Gene Tree for CEACAM19 (if available)

Paralogs for CEACAM19 Gene

No data available for Paralogs for CEACAM19 Gene

Variants for CEACAM19 Gene

Sequence variations from dbSNP and Humsavar for CEACAM19 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000032582 -- 44,683,861(+) GGCTC(C/G)CAACT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000085756 -- 44,675,532(+) TGTAA(A/T)CCCAA intron-variant
rs1000566853 -- 44,684,400(+) ATGGA(-/G)GGGGG intron-variant, upstream-variant-2KB
rs1000670380 -- 44,681,129(+) ACAAA(C/T)GTTAG intron-variant
rs1000908561 -- 44,672,848(+) CTTCC(C/T)CAATG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CEACAM19 Gene

Variant ID Type Subtype PubMed ID
nsv1062812 CNV gain 25217958
nsv483005 CNV loss 15286789
nsv9737 CNV gain 18304495

Variation tolerance for CEACAM19 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM19 Gene

Disorders for CEACAM19 Gene

Relevant External Links for CEACAM19

Genetic Association Database (GAD)
CEACAM19
Human Genome Epidemiology (HuGE) Navigator
CEACAM19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM19

No disorders were found for CEACAM19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM19 Gene

Publications for CEACAM19 Gene

  1. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. (PMID: 12801635) Scorilas A. … Diamandis E.P. (Gene 2003) 3 4 22 64
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression. (PMID: 23525470) Michaelidou K. … Scorilas A. (Int. J. Oncol. 2013) 3 64
  5. The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling. (PMID: 20374249) Shames S.R. … Finlay B.B. (Cell. Microbiol. 2010) 3 64

Products for CEACAM19 Gene

Sources for CEACAM19 Gene

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