CEACAM19 Gene
protein-coding GIFtS: 44
GCID: GC19P045174
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carcinoembryonic antigen-related cell adhesion molecule...
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Aliases
for CEACAM19 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carcinoembryonic Antigen-Related Cell Adhesion Molecule 191 2 | | CEAL11 2 3 | | Carcinoembryonic Antigen-Like 12 3 |
Export aliases for CEACAM19 gene to outside databasesPrevious GC identifers: GC19P049870 GC19P041606 |
Summaries
for CEACAM19 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CEACAM19 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CEACAM19 gene promoter:
SRF SRF (504 AA) STAT5A CUTL1 E4BP4 AREB6 FOXJ2 (long isoform) STAT3 ZID FOXJ2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEACAM19
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM19 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.31 Ensembl cytogenetic band: 19q13.31 HGNC cytogenetic band: 19q13.31CEACAM19 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P045174: view genomic region
(about GC identifiers)
Start:
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45,165,545 bp from pter |
End:
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45,187,631 bp from pter |
Size:
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22,087 bases |
Orientation:
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plus strand |
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Proteins
for CEACAM19 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEA19_HUMAN, Q7Z692 (See
protein sequence)Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 19 precursor Size: 300 amino acids; 32638 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAP70002.1; Type=Erroneous initiation; Sequence=AAP70003.1; Type=Erroneous initiation;
Secondary accessions: Q5XJ15 Q7Z693Alternative splicing: 3 isoforms: Q7Z692-1 Q7Z692-2 Q7Z692-3 Explore the universe of human proteins at neXtProt for CEACAM19: NX_Q7Z692
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q7Z692
CEACAM19 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001121365.1 NP_064604.2
ENSEMBL proteins: ENSP00000468753 ENSP00000465475 ENSP00000467819 ENSP00000465422 ENSP00000466592 ENSP00000351627 ENSP00000384887
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
CEACAM19 for ontologies About GeneDecksing
CEACAM19 Antibody Products:
Assay Products for CEACAM19: |
Protein
Domains /
Families
for CEACAM19 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CEACAM19 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q7Z692ProtoNet protein and cluster: Q7Z692 1 Blocks protein family: IPB013106 Immunoglobulin V-set
UniProtKB/Swiss-Prot: CEA19_HUMAN, Q7Z692Similarity: Belongs to the immunoglobulin superfamily. CEA family |
Function
for CEACAM19 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CEA19_HUMAN, Q7Z692Induction: Down-regulated by dexamethasone (in vitro)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM19 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for CEACAM19 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM19 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM19 |
Animal Models:
Mouse knock-out Ceacam19tm1Lex for CEACAM19
1 MGI phenotypic allele  for Ceacam19 (no phenotypes)
CEACAM19 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CEACAM19 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM19
|
Drugs & Compounds
for CEACAM19 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEACAM19
Search CenterWatch for drugs/clinical trials and news about CEACAM19 / CEA19
|
Transcripts
for CEACAM19 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEACAM19 gene (2 alternative transcripts): NM_001127893.1 NM_020219.3 Unigene Cluster for CEACAM19: Carcinoembryonic antigen-related cell adhesion molecule 19 Hs.416925 [show with all ESTs]Unigene Representative Sequence: AK1282349 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000592472 ENST00000587729 ENST00000585657 ENST00000592789 ENST00000591979
ENST00000358777(uc002ozo.4 uc002ozp.4) ENST00000403660 ENST00000480278
ENST00000459648
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM19 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM19 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): CEACAM19 (NM_020219) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEACAM19 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM19 |
Additional cDNA sequence: AK027157.1 AK128234.1 AK291588.1 AL390165.1 AY358394.1 BC083499.1 5 DOTS entries: DT.100747129 DT.110329 DT.101981633 DT.92061670 DT.95214282 24/329 AceView cDNA sequences (see all 329): F06714 BQ943688 AV649366 CA487502 BX110265 BQ877387 CF265015 BU146353 AV648002 BQ674835 CO245741 BQ448049 AA470006 BM743833 BM823693 BQ676646 BM670377 AA159556 BE221800 AA948101 AI613121 F04202 BQ233208 T17080
GeneLoc Exon Structure
|
Expression
for CEACAM19 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEACAM19 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CEACAM19 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEACAM19
SOURCE GeneReport for Unigene cluster: Hs.416925
UniProtKB/Swiss-Prot: CEA19_HUMAN, Q7Z692Tissue specificity: Ubiquitous with highest expression in prostate, uterus, fetal brain, mammary gland, adrenal gland,skeletal muscle, small intestine, and kidney, and lower expression in lung, cerebellum, testis, liver, pancreas, bonemarrow and ovary
SABiosciences Custom PCR Arrays for CEACAM19
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEACAM19
Browse OriGene validated miRNA SYBR primer pairs
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM19 |
Orthologs
for CEACAM19 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for CEACAM19 gene from 1/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Ceacam191 , 5 |
carcinoembryonic antigen-related cell adhesion molecule more1, 5 |
75.7(n)1
69.08(a)1 |
|
7 (9.95 cM)5
3199301 NM_177036.51 NP_796010.11
198757425 |
ENSEMBL Gene Tree for CEACAM19 (if available)
TreeFam Gene Tree for CEACAM19 (if available) |
Paralogs
for CEACAM19 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for CEACAM19 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEACAM19 (45165545 - 45187631 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CEACAM19
2 CNVs: 0221 30910 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEACAM19 |
|
Disorders
/ Diseases
for CEACAM19 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEACAM19 for disorders About GeneDecksing
OMIM gene information: 606691
OMIM disorders: --
1  disease for CEACAM19: About MalaCardsprostatitis
Human Genome Epidemiology (HuGE) Navigator: CEACAM19 (1 document)
Export disorders for CEACAM19 gene to outside databases
|
Publications
for CEACAM19 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEACAM19 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CEACAM19) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. (PubMed id 12801635)1, 2, 9 Scorilas A.... Diamandis E.P. (2003)
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
- Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1 Jugessur A....Murray J.C. (2010)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for CEACAM19 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CEACAM19 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEACAM19 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEACAM19 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEACAM19 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CEACAM19 gene:
Search GeneIP for patents involving CEACAM19
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEACAM19 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | CEACAM19 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM19 |
|  |  |  | | | | Search ThermoFisher Antibodies for CEACAM19 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM19 |
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