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Aliases for CEACAM19 Gene

Aliases for CEACAM19 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 19 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 19 2 3
  • Carcinoembryonic Antigen-Like 1 3 4
  • CEAL1 3 4
  • CEACM19 3

External Ids for CEACAM19 Gene

Previous GeneCards Identifiers for CEACAM19 Gene

  • GC19P049870
  • GC19P045174
  • GC19P041606

Summaries for CEACAM19 Gene

GeneCards Summary for CEACAM19 Gene

CEACAM19 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 19) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM19 Gene

Genomics for CEACAM19 Gene

Regulatory Elements for CEACAM19 Gene

Enhancers for CEACAM19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F044633 1.3 Ensembl ENCODE 22.1 -22.9 -22881 11.1 HDGF MLX ARID4B SIN3A DMAP1 YY1 ZNF143 ZNF263 MXD4 REST PVR CEACAM19 ZNF45 ZNF284 ZNF225 ZNF223 ENSG00000252200 ZNF180 LOC105372418 CEACAM22P
GH19F045089 1.2 ENCODE 21.8 +430.1 430115 5.3 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF180 CCDC61 ZNF224 ZNF234 ZNF225 ENSG00000269148 GEMIN7 FBXO46 CEACAM19 DMWD
GH19F044586 1.8 FANTOM5 Ensembl ENCODE 13.5 -72.1 -72089 8.1 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 ZNF143 ZNF548 ZNF263 SP3 TBX21 ZNF180 ZNF45 ZNF234 ZNF155 ZNF284 ZNF225 NECTIN2 EXOC3L2 LOC105372418 ENSG00000267614
GH19F044676 1.2 Ensembl ENCODE 17.5 +15.2 15193 1.1 CBX3 PKNOX1 SIN3A ZEB1 ZNF366 FOS NFYA NFYC OVOL3 USF2 CEACAM19 MRPS15P2 ZNF45 ZNF234 ZNF180 IRGC GC19P044686 ENSG00000279095
GH19F043773 1.8 FANTOM5 Ensembl ENCODE 11.3 -882.6 -882593 12.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A YBX1 ZNF2 ZNF302 ZNF45 ZNF180 ZNF225 ZNF284 ZNF224 ZNF234 KCNN4 XRCC1 ZNF223 LOC100505715
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM19 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM19 Gene

Chromosome:
19
Start:
44,662,278 bp from pter
End:
44,684,359 bp from pter
Size:
22,082 bases
Orientation:
Plus strand

Genomic View for CEACAM19 Gene

Genes around CEACAM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM19 Gene

Proteins for CEACAM19 Gene

  • Protein details for CEACAM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z692-CEA19_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 19
    Protein Accession:
    Q7Z692
    Secondary Accessions:
    • Q5XJ15
    • Q7Z693

    Protein attributes for CEACAM19 Gene

    Size:
    300 amino acids
    Molecular mass:
    32638 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAP70002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP70003.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM19 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CEACAM19 Gene

Post-translational modifications for CEACAM19 Gene

  • Glycosylation at Asn 104
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM19 Gene

No data available for DME Specific Peptides for CEACAM19 Gene

Domains & Families for CEACAM19 Gene

Protein Domains for CEACAM19 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z692

UniProtKB/Swiss-Prot:

CEA19_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM19: view

Function for CEACAM19 Gene

Molecular function for CEACAM19 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated by dexamethasone (in vitro).

Phenotypes for CEACAM19 Gene

genes like me logo Genes that share phenotypes with CEACAM19: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CEACAM19

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM19 Gene

Localization for CEACAM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM19 gene
Compartment Confidence
plasma membrane 2
nucleus 2
extracellular 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CEACAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM19: view

Pathways & Interactions for CEACAM19 Gene

SuperPathways for CEACAM19 Gene

No Data Available

Interacting Proteins for CEACAM19 Gene

Selected Interacting proteins: Q7Z692-CEA19_HUMAN for CEACAM19 Gene via IID

Symbol External ID(s) Details
BCL3
MIR8085

Gene Ontology (GO) - Biological Process for CEACAM19 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM19 Gene

Transcripts for CEACAM19 Gene

Unigene Clusters for CEACAM19 Gene

Carcinoembryonic antigen-related cell adhesion molecule 19:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM19 Gene

No ASD Table

Relevant External Links for CEACAM19 Gene

GeneLoc Exon Structure for
CEACAM19
ECgene alternative splicing isoforms for
CEACAM19

Expression for CEACAM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CEACAM19 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEACAM19 Gene:

CEACAM19

SOURCE GeneReport for Unigene cluster for CEACAM19 Gene:

Hs.416925

mRNA Expression by UniProt/SwissProt for CEACAM19 Gene:

Q7Z692-CEA19_HUMAN
Tissue specificity: Ubiquitous with highest expression in prostate, uterus, fetal brain, mammary gland, adrenal gland, skeletal muscle, small intestine, and kidney, and lower expression in lung, cerebellum, testis, liver, pancreas, bone marrow and ovary.
genes like me logo Genes that share expression patterns with CEACAM19: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CEACAM19 Gene

Orthologs for CEACAM19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM19 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM19 34 35
  • 99.39 (n)
dog
(Canis familiaris)
Mammalia CEACAM19 34
  • 81.15 (n)
cow
(Bos Taurus)
Mammalia CEACAM19 34 35
  • 79.18 (n)
rat
(Rattus norvegicus)
Mammalia Ceacam19 34
  • 77.21 (n)
mouse
(Mus musculus)
Mammalia Ceacam19 34 16 35
  • 75.7 (n)
oppossum
(Monodelphis domestica)
Mammalia CEACAM19 35
  • 43 (a)
OneToOne
Species where no ortholog for CEACAM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM19 Gene

ENSEMBL:
Gene Tree for CEACAM19 (if available)
TreeFam:
Gene Tree for CEACAM19 (if available)

Paralogs for CEACAM19 Gene

No data available for Paralogs for CEACAM19 Gene

Variants for CEACAM19 Gene

Sequence variations from dbSNP and Humsavar for CEACAM19 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10406189 -- 44,674,840(+) TCCGG(C/T)TGGAG intron-variant
rs111607487 -- 44,678,759(+) CCCCC(C/T)TCTCC intron-variant
rs111708718 -- 44,678,225(+) AAGCG(A/G)TCCTT intron-variant
rs111723942 -- 44,670,413(+) CTCAT(A/G)CCTAT intron-variant, upstream-variant-2KB
rs111861405 -- 44,682,110(+) CTAGG(C/T)ATGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM19 Gene

Variant ID Type Subtype PubMed ID
nsv9737 CNV gain 18304495
nsv483005 CNV loss 15286789
nsv1062812 CNV gain 25217958

Variation tolerance for CEACAM19 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM19

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM19 Gene

Disorders for CEACAM19 Gene

Relevant External Links for CEACAM19

Genetic Association Database (GAD)
CEACAM19
Human Genome Epidemiology (HuGE) Navigator
CEACAM19
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM19

No disorders were found for CEACAM19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM19 Gene

Publications for CEACAM19 Gene

  1. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. (PMID: 12801635) Scorilas A. … Diamandis E.P. (Gene 2003) 3 4 22 64
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A. … Murray J.C. (PLoS ONE 2010) 3 46 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression. (PMID: 23525470) Michaelidou K. … Scorilas A. (Int. J. Oncol. 2013) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for CEACAM19 Gene

Sources for CEACAM19 Gene

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