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Aliases for CEACAM19 Gene

Aliases for CEACAM19 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 19 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 19 2 3
  • Carcinoembryonic Antigen-Like 1 3 4
  • CEAL1 3 4
  • CEACM19 3

External Ids for CEACAM19 Gene

Previous GeneCards Identifiers for CEACAM19 Gene

  • GC19P049870
  • GC19P045174
  • GC19P041606

Summaries for CEACAM19 Gene

GeneCards Summary for CEACAM19 Gene

CEACAM19 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 19) is a Protein Coding gene.

Additional gene information for CEACAM19 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM19 Gene

Genomics for CEACAM19 Gene

Regulatory Elements for CEACAM19 Gene

Enhancers for CEACAM19 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H043773 2 FANTOM5 Ensembl ENCODE dbSUPER 31.8 -882.4 -882377 12.4 YBX1 ZNF416 ZNF143 SP3 ZC3H11A ZFP41 MEF2D ZNF610 ZNF585B GLIS1 ZNF180 ZNF45 ZNF225 ZNF227 ZNF284 ZNF223 ZNF224 ZNF283 ZNF235 ZNF576
GH19H044844 1.8 FANTOM5 ENCODE dbSUPER 21.8 +185.7 185737 7.3 YBX1 DMAP1 YY1 ZNF416 ZNF143 SP3 MCM3 ZNF610 GLIS1 RCOR2 ZNF180 ZNF45 CLASRP ZNF224 ZNF225 ZNF234 ZNF284 FBXO46 ENSG00000269148 LOC100505715
GH19H044633 1.5 Ensembl ENCODE dbSUPER 22.1 -22.9 -22881 11.1 FOXA2 MLX ARID4B SIN3A DMAP1 YY1 TCF12 ZNF766 GLIS2 YY2 PVR CEACAM19 ENSG00000267114 ZNF223 ENSG00000252200 ZNF227 ZNF235 ZNF226 CEACAM22P
GH19H044586 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.6 -72.1 -72089 8.1 PKNOX1 ARNT SIN3A CBX5 ZNF302 FOS REST ZNF592 MEF2D SMARCA4 MRPS15P2 ZNF283 ZNF225 ZNF180 ZNF221 ZNF45 ENSG00000267191 ZNF234 ZNF224 LOC101928063
GH19H044683 1.4 FANTOM5 Ensembl ENCODE 18 +23.2 23178 3.5 HDAC1 PKNOX1 PTBP1 NFRKB SIN3A BATF TCF12 ZNF121 EGR1 FOS CEACAM19 PVR ZNF180 ENSG00000252200 ZNF45 RELB ENSG00000266903 BCL3 CLASRP BLOC1S3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM19 on UCSC Golden Path with GeneCards custom track

Genomic Locations for CEACAM19 Gene

Genomic Locations for CEACAM19 Gene
22,082 bases
Plus strand

Genomic View for CEACAM19 Gene

Genes around CEACAM19 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM19 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM19 Gene

Proteins for CEACAM19 Gene

  • Protein details for CEACAM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 19
    Protein Accession:
    Secondary Accessions:
    • Q5XJ15
    • Q7Z693

    Protein attributes for CEACAM19 Gene

    300 amino acids
    Molecular mass:
    32638 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAP70002.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAP70003.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for CEACAM19 Gene


neXtProt entry for CEACAM19 Gene

Post-translational modifications for CEACAM19 Gene

  • Glycosylation at Asn104
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM19 Gene

No data available for DME Specific Peptides for CEACAM19 Gene

Domains & Families for CEACAM19 Gene

Gene Families for CEACAM19 Gene

Protein Domains for CEACAM19 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the immunoglobulin superfamily. CEA family.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM19: view

Function for CEACAM19 Gene

Molecular function for CEACAM19 Gene

UniProtKB/Swiss-Prot Induction:
Down-regulated by dexamethasone (in vitro).

Phenotypes From GWAS Catalog for CEACAM19 Gene

Gene Ontology (GO) - Molecular Function for CEACAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 20374249
genes like me logo Genes that share ontologies with CEACAM19: view

Phenotypes for CEACAM19 Gene

genes like me logo Genes that share phenotypes with CEACAM19: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM19 Gene

Localization for CEACAM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM19 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM19 gene
Compartment Confidence
plasma membrane 2
nucleus 2
extracellular 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CEACAM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CEACAM19: view

Pathways & Interactions for CEACAM19 Gene

SuperPathways for CEACAM19 Gene

No Data Available

Interacting Proteins for CEACAM19 Gene

Selected Interacting proteins: Q7Z692-CEA19_HUMAN for CEACAM19 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for CEACAM19 Gene


No data available for Pathways by source and SIGNOR curated interactions for CEACAM19 Gene

Drugs & Compounds for CEACAM19 Gene

No Compound Related Data Available

Transcripts for CEACAM19 Gene

Unigene Clusters for CEACAM19 Gene

Carcinoembryonic antigen-related cell adhesion molecule 19:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM19 Gene

No ASD Table

Relevant External Links for CEACAM19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CEACAM19 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM19 Gene

NURSA nuclear receptor signaling pathways regulating expression of CEACAM19 Gene:


SOURCE GeneReport for Unigene cluster for CEACAM19 Gene:


mRNA Expression by UniProt/SwissProt for CEACAM19 Gene:

Tissue specificity: Ubiquitous with highest expression in prostate, uterus, fetal brain, mammary gland, adrenal gland, skeletal muscle, small intestine, and kidney, and lower expression in lung, cerebellum, testis, liver, pancreas, bone marrow and ovary.
genes like me logo Genes that share expression patterns with CEACAM19: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM19 Gene

Orthologs for CEACAM19 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM19 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CEACAM19 33 34
  • 99.39 (n)
(Canis familiaris)
Mammalia CEACAM19 33
  • 81.15 (n)
(Bos Taurus)
Mammalia CEACAM19 33 34
  • 79.18 (n)
(Rattus norvegicus)
Mammalia Ceacam19 33
  • 77.21 (n)
(Mus musculus)
Mammalia Ceacam19 33 16 34
  • 75.7 (n)
(Monodelphis domestica)
Mammalia CEACAM19 34
  • 43 (a)
Species where no ortholog for CEACAM19 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM19 Gene

Gene Tree for CEACAM19 (if available)
Gene Tree for CEACAM19 (if available)

Paralogs for CEACAM19 Gene

No data available for Paralogs for CEACAM19 Gene

Variants for CEACAM19 Gene

Sequence variations from dbSNP and Humsavar for CEACAM19 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000032582 -- 44,683,861(+) GGCTC(C/G)CAACT intron-variant, upstream-variant-2KB, utr-variant-3-prime
rs1000085756 -- 44,675,532(+) TGTAA(A/T)CCCAA intron-variant
rs1000566853 -- 44,684,400(+) ATGGA(-/G)GGGGG intron-variant, upstream-variant-2KB
rs1000670380 -- 44,681,129(+) ACAAA(C/T)GTTAG intron-variant
rs1000908561 -- 44,672,848(+) CTTCC(C/T)CAATG intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CEACAM19 Gene

Variant ID Type Subtype PubMed ID
nsv9737 CNV gain 18304495
nsv483005 CNV loss 15286789
nsv1062812 CNV gain 25217958

Variation tolerance for CEACAM19 Gene

Residual Variation Intolerance Score: 89.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.25; 52.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM19 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM19 Gene

Disorders for CEACAM19 Gene

Relevant External Links for CEACAM19

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CEACAM19 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM19 Gene

Publications for CEACAM19 Gene

  1. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. (PMID: 12801635) Scorilas A … Diamandis EP (Gene 2003) 3 4 22 60
  2. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 45 60
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  4. The expression of the CEACAM19 gene, a novel member of the CEA family, is associated with breast cancer progression. (PMID: 23525470) Michaelidou K … Scorilas A (International journal of oncology 2013) 3 60
  5. The pathogenic E. coli type III effector EspZ interacts with host CD98 and facilitates host cell prosurvival signalling. (PMID: 20374249) Shames SR … Finlay BB (Cellular microbiology 2010) 3 60

Products for CEACAM19 Gene

Sources for CEACAM19 Gene

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