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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM19 Gene

protein-coding   GIFtS: 44
GCID: GC19P045174

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 191 2
Carcinoembryonic Antigen-Like 12 3
CEAL12 3

External Ids:    HGNC: 319511   Entrez Gene: 569712   Ensembl: ENSG000001865677   OMIM: 6066915   UniProtKB: Q7Z6923   

Export aliases for CEACAM19 gene to outside databases

Previous GC identifers: GC19P049870 GC19P041606


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEACAM19 Gene: 
CEACAM19 (carcinoembryonic antigen-related cell adhesion molecule 19) is a protein-coding gene. Diseases associated with CEACAM19 include prostatitis.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM19 gene promoter:
         SRF   SRF (504 AA)   STAT5A   CUTL1   E4BP4   AREB6   FOXJ2 (long isoform)   STAT3   ZID   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCEACAM19 promoter sequence
   Search SABiosciences Chromatin IP Primers for CEACAM19

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM19


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.31   Ensembl cytogenetic band:  19q13.31   HGNC cytogenetic band: 19q13.31

CEACAM19 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM19 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045174:  view genomic region     (about GC identifiers)

Start:
45,165,545 bp from pter      End:
45,187,631 bp from pter
Size:
22,087 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEA19_HUMAN, Q7Z692 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 19 precursor  
Size: 300 amino acids; 32638 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Sequence caution: Sequence=AAP70002.1; Type=Erroneous initiation; Sequence=AAP70003.1; Type=Erroneous initiation;
Secondary accessions: Q5XJ15 Q7Z693
Alternative splicing: 3 isoforms:  Q7Z692-1   Q7Z692-2   Q7Z692-3   

Explore the universe of human proteins at neXtProt for CEACAM19: NX_Q7Z692

Explore proteomics data for CEACAM19 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q7Z692

  • CEACAM19 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CEACAM19 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001121365.1  NP_064604.2  

    ENSEMBL proteins: 
     ENSP00000468753   ENSP00000465475   ENSP00000467819   ENSP00000465422   ENSP00000466592  
     ENSP00000351627   ENSP00000384887  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    CEACAM19 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    VSET: Immunoglobulin superfamily / V-set domain containing

    2 InterPro protein domains:
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set

    Graphical View of Domain Structure for InterPro Entry Q7Z692

    ProtoNet protein and cluster: Q7Z692

    1 Blocks protein domain: IPB013106 Immunoglobulin V-set

    UniProtKB/Swiss-Prot: CEA19_HUMAN, Q7Z692
    Similarity: Belongs to the immunoglobulin superfamily. CEA family


    CEACAM19 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEA19_HUMAN, Q7Z692
    Induction: Down-regulated by dexamethasone (in vitro)

    Phenotypes:
         1 MGI phenotypic allele for Ceacam19 (no phenotypes)


    CEACAM19 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ceacam19tm1Lex for CEACAM19

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM19

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEACAM19 (CEA19)

    Search CenterWatch for drugs/clinical trials and news about CEACAM19 / CEA19

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEACAM19 gene (2 alternative transcripts): 
    NM_001127893.1  NM_020219.3  

    Unigene Cluster for CEACAM19:

    Carcinoembryonic antigen-related cell adhesion molecule 19
    Hs.416925  [show with all ESTs]
    Unigene Representative Sequence: AK128234
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000592472 ENST00000587729 ENST00000585657 ENST00000592789 ENST00000591979
    ENST00000358777(uc002ozo.4 uc002ozp.4) ENST00000403660 ENST00000480278
    ENST00000459648
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    hsa-miR-137 hsa-miR-4312
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK027157.1 AK128234.1 AK291588.1 AL390165.1 AY358394.1 BC083499.1 

    5 DOTS entries:

    DT.100747129  DT.110329  DT.101981633  DT.92061670  DT.95214282 

    24/329 AceView cDNA sequences (see all 329):

    AV648002 AA159556 AV649366 F06714 W02164 AA583490 BM723085 BM990082 
    CO245741 BE301927 CD367987 BM823693 BX646992 CO247073 BQ943688 AA948101 
    BM743833 CO245872 CA429918 BM766586 NM_006505 BF002687 CA487502 BQ674835 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEACAM19 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEACAM19 Expression
    About this image


    See CEACAM19 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CEACAM19

    SOURCE GeneReport for Unigene cluster: Hs.416925

    UniProtKB/Swiss-Prot: CEA19_HUMAN, Q7Z692
    Tissue specificity: Ubiquitous with highest expression in prostate, uterus, fetal brain, mammary gland, adrenal
    gland, skeletal muscle, small intestine, and kidney, and lower expression in lung, cerebellum, testis, liver,
    pancreas, bone marrow and ovary

        SABiosciences Custom PCR Arrays for CEACAM19
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM19

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for CEACAM19 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ceacam191 , 5 carcinoembryonic antigen-related cell adhesion molecule more1, 5 75.7(n)1
    69.08(a)1
      7 (9.95 cM)5
    3199301  NM_177036.51  NP_796010.11 
     198757425 


    ENSEMBL Gene Tree for CEACAM19 (if available)
    TreeFam Gene Tree for CEACAM19 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 SNPs in CEACAM19 are shown (see all 394)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1475563201,2
    --45172781(+) CTCTGA/TTGATC 2 -- us2k10--------
    rs621193211,2
    C,F--45172785(+) GTTGAC/TCCAAC 2 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1923713901,2
    --45172925(+) ACATCC/GTTGCA 2 -- us2k10--------
    rs1161654701,2
    F--45172971(+) CTCACC/TCCATC 2 -- us2k11Minor allele frequency- T:0.01WA 118
    rs1149458941,2
    F--45173029(+) CTCCCC/GCAGGA 2 -- us2k11Minor allele frequency- G:0.01WA 118
    rs739368421,2
    C--45173081(+) GGGCTC/TTCCCA 2 -- us2k13Minor allele frequency- T:0.12WA EA 240
    rs1850668261,2
    --45173142(+) GTGAGA/CGGGGT 2 -- us2k10--------
    rs1437072651,2
    C--45173149(+) GGTCT-/GGCCCC 2 -- us2k10--------
    rs595691051,2
    F--45173156(+) CCCCCC/TCAAAC 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1142226901,2
    F--45173318(+) GCCAGG/ATATGG 2 -- us2k11Minor allele frequency- A:0.01WA 118

    HapMap Linkage Disequilibrium report for CEACAM19 (45165545 - 45187631 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CEACAM19:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912116CNV Loss21882294
    nsv483005CNV Loss15286789
    nsv9737CNV Gain18304495

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606691    OMIM disorders: --

    2 diseases for CEACAM19:    About MalaCards
    prostatitis    


    CEACAM19 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CEACAM19
    Human Genome Epidemiology (HuGE) Navigator: CEACAM19 (1 document)

    Export disorders for CEACAM19 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEACAM19 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CEACAM19)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of a new gene, CEAL1, encoding for a carcinoembryonic antigen-like protein with a highly conserved domain of eukaryotic translation initiation factors. (PubMed id 12801635)1, 2, 9 Scorilas A.... Diamandis E.P. (2003)
    2. Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)1, 4 Jugessur A....Murray J.C. (2010)
    3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    4. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56971 HGNC: 31951 AceView: PVRandCEAL1andLOC440536 Ensembl:ENSG00000186567 euGenes: HUgn56971
    ECgene: CEACAM19 H-InvDB: CEACAM19

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEACAM19 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEACAM19 gene:
    Search GeneIP for patents involving CEACAM19

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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