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Aliases for CEACAM18 Gene

Aliases for CEACAM18 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 18 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 18 2

External Ids for CEACAM18 Gene

Previous GeneCards Identifiers for CEACAM18 Gene

  • GC19U900557
  • GC19P056674
  • GC19P051979
  • GC19P048311

Summaries for CEACAM18 Gene

GeneCards Summary for CEACAM18 Gene

CEACAM18 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 18) is a Protein Coding gene. An important paralog of this gene is CEACAM5.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM18 Gene

Genomics for CEACAM18 Gene

Regulatory Elements for CEACAM18 Gene

Enhancers for CEACAM18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G051545 2 FANTOM5 Ensembl ENCODE dbSUPER 11.8 +71.2 71227 8.0 MLX CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 NFYC MEF2D NBN ZNF175 SIGLEC6 SIGLEC14 SIGLEC8 CEACAM18 SIGLEC12 RPL7P51 SIGLEC5 MIR125A MIRLET7E
GH19G051570 1.6 FANTOM5 ENCODE dbSUPER 10.3 +93.7 93681 3.6 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF766 ZNF143 ZNF175 SIGLEC14 SIGLEC5 RPL7P51 CEACAM18 SIGLEC8 SPACA6P-AS FPR3 ZNF615 SIGLEC6
GH19G051544 1.1 dbSUPER 11.8 +66.3 66253 1.6 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 MXD4 SIGLEC12 CEACAM18 SIGLEC8 RPL7P51 SIGLEC14 SIGLEC5 SIGLEC28P SIGLEC6
GH19G051531 1.1 Ensembl ENCODE 11.6 +53.2 53165 1.4 HDAC1 TBP CBX3 ZBTB40 ZNF766 CBX5 ZNF143 IKZF2 CREM KDM4B SIGLEC12 CEACAM18 SIGLEC8 SIGLEC5 RPL7P51 SIGLEC14 SIGLEC6 ENSG00000268777
GH19G051701 1.1 ENCODE 11 +225.0 224959 4.0 HDGF PKNOX1 CREB3L1 AGO1 ARID4B SIN3A ZBTB7B ZNF766 ZNF143 KLF13 SIGLEC14 HAS1 FPR1 FPR3 CEACAM18 RPL7P51 SIGLEC5 SPACA6P-AS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM18 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM18 Gene

Chromosome:
19
Start:
51,478,547 bp from pter
End:
51,491,261 bp from pter
Size:
12,715 bases
Orientation:
Plus strand

Genomic View for CEACAM18 Gene

Genes around CEACAM18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM18 Gene

Proteins for CEACAM18 Gene

  • Protein details for CEACAM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTB9-CEA18_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 18
    Protein Accession:
    A8MTB9
    Secondary Accessions:
    • C9JN24

    Protein attributes for CEACAM18 Gene

    Size:
    384 amino acids
    Molecular mass:
    43320 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CEACAM18 Gene

Post-translational modifications for CEACAM18 Gene

  • Glycosylation at posLast=108108, posLast=112112, posLast=121121, Asn162, and Asn270

Other Protein References for CEACAM18 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEACAM18 Gene

Domains & Families for CEACAM18 Gene

Protein Domains for CEACAM18 Gene

Suggested Antigen Peptide Sequences for CEACAM18 Gene

Graphical View of Domain Structure for InterPro Entry

A8MTB9

UniProtKB/Swiss-Prot:

CEA18_HUMAN :
  • Belongs to the immunoglobulin superfamily. CEA family.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM18: view

Function for CEACAM18 Gene

Phenotypes for CEACAM18 Gene

GenomeRNAi human phenotypes for CEACAM18:
genes like me logo Genes that share phenotypes with CEACAM18: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CEACAM18

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CEACAM18 Gene

Localization for CEACAM18 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM18 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
extracellular 1
endoplasmic reticulum 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CEACAM18 Gene

Pathways & Interactions for CEACAM18 Gene

SuperPathways for CEACAM18 Gene

No Data Available

Interacting Proteins for CEACAM18 Gene

Gene Ontology (GO) - Biological Process for CEACAM18 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CEACAM18 Gene

Drugs & Compounds for CEACAM18 Gene

No Compound Related Data Available

Transcripts for CEACAM18 Gene

mRNA/cDNA for CEACAM18 Gene

(3) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM18 Gene

No ASD Table

Relevant External Links for CEACAM18 Gene

GeneLoc Exon Structure for
CEACAM18
ECgene alternative splicing isoforms for
CEACAM18

Expression for CEACAM18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM18 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM18 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x50.6).

NURSA nuclear receptor signaling pathways regulating expression of CEACAM18 Gene:

CEACAM18

SOURCE GeneReport for Unigene cluster for CEACAM18 Gene:

Hs.653111
genes like me logo Genes that share expression patterns with CEACAM18: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM18 Gene

Orthologs for CEACAM18 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM18 34 35
  • 98.27 (n)
cow
(Bos Taurus)
Mammalia LOC615876 34
  • 73.28 (n)
CEACAM18 35
  • 55 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC484346 34
  • 73.28 (n)
CEACAM18 35
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ceacam18 34 16 35
  • 71.19 (n)
rat
(Rattus norvegicus)
Mammalia Ceacam18 34
  • 69.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 29 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 24 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 9 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:dkey-11o1.2 35
  • 19 (a)
ManyToMany
si:dkey-250k15.9 35
  • 18 (a)
ManyToMany
si:dkey-250k15.10 35
  • 16 (a)
ManyToMany
cxcr3.1 35
  • 15 (a)
ManyToMany
si:dkey-11o1.3 35
  • 14 (a)
ManyToMany
si:dkey-250k15.7 35
  • 13 (a)
ManyToMany
si:ch211-264f5.6 35
  • 12 (a)
ManyToMany
ceacam1 35
  • 5 (a)
ManyToMany
Species where no ortholog for CEACAM18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEACAM18 Gene

ENSEMBL:
Gene Tree for CEACAM18 (if available)
TreeFam:
Gene Tree for CEACAM18 (if available)

Paralogs for CEACAM18 Gene

(4) SIMAP similar genes for CEACAM18 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CEACAM18 Gene

genes like me logo Genes that share paralogs with CEACAM18: view

Variants for CEACAM18 Gene

Sequence variations from dbSNP and Humsavar for CEACAM18 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000199612 -- 51,479,735(+) CCTGC(C/G/T)GGGAA intron-variant
rs1000484790 -- 51,479,940(+) CACCA(A/G)CTCTG intron-variant
rs1000622458 -- 51,491,334(+) AGTGA(A/C)ATAAG downstream-variant-500B, utr-variant-3-prime
rs1000624739 -- 51,483,195(+) CTCTC(A/G)AGTCT reference, synonymous-codon
rs1000717429 -- 51,485,517(+) GAAGA(G/T)ATTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM18 Gene

Variant ID Type Subtype PubMed ID
esv2758767 CNV gain+loss 17122850
esv3357728 CNV insertion 20981092
esv3644671 CNV loss 21293372
nsv1140251 OTHER inversion 24896259

Variation tolerance for CEACAM18 Gene

Gene Damage Index Score: 6.84; 79.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM18 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM18 Gene

Disorders for CEACAM18 Gene

Relevant External Links for CEACAM18

Genetic Association Database (GAD)
CEACAM18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM18

No disorders were found for CEACAM18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CEACAM18 Gene

Publications for CEACAM18 Gene

  1. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PMID: 16139472) Zebhauser R. … Zimmermann W. (Genomics 2005) 3 64
  2. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64

Products for CEACAM18 Gene

Sources for CEACAM18 Gene

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