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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM18 Gene

protein-coding   GIFtS: 32
GCID: GC19P051979

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...

  Search for CEACAM18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 181 2

External Ids:    HGNC: 319491   Entrez Gene: 7297672   Ensembl: ENSG000002138227   UniProtKB: A8MTB93   

Export aliases for CEACAM18 gene to outside databases

Previous GC identifers: GC19U900557 GC19P056674 GC19P048311


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CEACAM18 Gene: 
CEACAM18 (carcinoembryonic antigen-related cell adhesion molecule 18) is a protein-coding gene. An important paralog of this gene is PSG9.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM18 gene promoter:
         HOXA9B   RelA   NF-kappaB   Tal-1beta   E47   RORalpha1   ARP-1   c-Myb   NF-kappaB1   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CEACAM18

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

CEACAM18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM18 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051979:  view genomic region     (about GC identifiers)

Start:
51,979,838 bp from pter      End:
51,994,206 bp from pter
Size:
14,369 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEA18_HUMAN, A8MTB9 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 18 precursor  
Size: 384 amino acids; 43320 Da
Secondary accessions: C9JN24

Explore the universe of human proteins at neXtProt for CEACAM18: NX_A8MTB9

Explore proteomics data for CEACAM18 at MOPED 

CEACAM18 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CEACAM18 Protein Expression

REFSEQ proteins: NP_001265321.1  
ENSEMBL proteins: 
 ENSP00000379738   ENSP00000402203  

Human Recombinant Protein Products for CEACAM18: 
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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
VSET: Immunoglobulin superfamily / V-set domain containing

4 InterPro protein domains:
 IPR003598 Ig_sub2
 IPR013783 Ig-like_fold
 IPR013106 Ig_V-set
 IPR007110 Ig-like_dom

Graphical View of Domain Structure for InterPro Entry A8MTB9

ProtoNet protein and cluster: A8MTB9

UniProtKB/Swiss-Prot: CEA18_HUMAN, A8MTB9
Similarity: Belongs to the immunoglobulin superfamily. CEA family
Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


CEACAM18 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
     
CEACAM18 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM18

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEACAM18 (CEA18)

Search CenterWatch for drugs/clinical trials and news about CEACAM18 / CEA18

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CEACAM18 gene (2 alternative transcripts): 
NM_001278392.1  NM_001080405.1  

Unigene Cluster for CEACAM18:

Carcinoembryonic antigen-related cell adhesion molecule 18
Hs.653111
Unigene Representative Sequence: NM_001080405
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000396477 ENST00000451626(uc002pwv.1)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEACAM18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTTGCACAT
CEACAM18 Expression
About this image


See CEACAM18 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.653111
    SABiosciences Custom PCR Arrays for CEACAM18
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for CEACAM18 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Ceacam181 , 5 carcinoembryonic antigen-related cell adhesion molecule more1, 5 72.36(n)1
63.61(a)1
  7 (28.25 cM)5
724311  NM_028236.11  NP_082512.11 
 436347395 


ENSEMBL Gene Tree for CEACAM18 (if available)
TreeFam Gene Tree for CEACAM18 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CEACAM18 gene
PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
PSG12  PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  PSG22  
CEACAM162  PSG42  CEACAM32  PSG72  
4 SIMAP similar genes for CEACAM18 using alignment to 2 protein entries:     CEA18_HUMAN (see all proteins):
CEA    CEACAM1    CEACAM3    CEACAM5

CEACAM18 for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for CEACAM18
PGOHUM00000234374


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/302 SNPs in CEACAM18 are shown (see all 302)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs93047141,2
C,F,A,H--51977887(+) tcaaaC/Acagac 1 -- us2k15Minor allele frequency- A:0.01NS EA 538
rs81017771,2
C,F,A,H--51977891(+) ACCAGA/GCAGTG 1 -- us2k120Minor allele frequency- G:0.18NS EA NA CSA WA 2345
rs1380173361,2
C--51977937(+) TCAAA-/CCAGCC 1 -- us2k10--------
rs93047151,2
C,F,A--51977965(+) AGCAGT/CCCTCA 1 -- us2k12Minor allele frequency- C:0.03WA EA 238
rs113910161,2
C--51977977(+) GGGGGG/-CAGTG 1 -- us2k12Minor allele frequency- -:0.25CSA 4
rs730496841,2
C,F--51978105(+) CTCATG/ATTATG 1 -- us2k11Minor allele frequency- A:0.03NA 120
rs1923929711,2
--51978219(+) CAGTAC/GAATCA 1 -- us2k10--------
rs735588331,2
C,F--51978253(+) CATGAC/TGTGTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
rs1410707891,2
--51978306(+) GCCTTC/GATGCC 1 -- us2k10--------
rs93047161,2
C,F,A,H--51978351(+) ggatgG/Actgtt 1 -- us2k15Minor allele frequency- A:0.01NS EA WA 538

HapMap Linkage Disequilibrium report for CEACAM18 (51979838 - 51994206 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for CEACAM18: --
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CEACAM18 for disorders           About MalaCards

CEACAM18 for disorders           About GeneDecksing

Genetic Association Database (GAD): CEACAM18

Export disorders for CEACAM18 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CEACAM18 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CEACAM18)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PubMed id 16139472)1 Zebhauser R....Zimmermann W. (2005)
  2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 729767 HGNC: 31949 Ensembl:ENSG00000213822 euGenes: HUgn729767 ECgene: CEACAM18
H-InvDB: CEACAM18

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CEACAM18 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CEACAM18 gene:
Search GeneIP for patents involving CEACAM18

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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