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CEACAM18 Gene

protein-coding   GIFtS: 32
GCID: GC19P051979

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...

  Search for CEACAM18
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 181 2

External Ids:    HGNC: 319491   Entrez Gene: 7297672   Ensembl: ENSG000002138227   UniProtKB: A8MTB93   

Export aliases for CEACAM18 gene to outside databases

Previous GC identifers: GC19U900557 GC19P056674 GC19P048311


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CEACAM18 Gene:
CEACAM18 (carcinoembryonic antigen-related cell adhesion molecule 18) is a protein-coding gene. An important paralog of this gene is PSG9.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEACAM18 gene promoter:
         HOXA9B   RelA   NF-kappaB   Tal-1beta   E47   RORalpha1   ARP-1   c-Myb   NF-kappaB1   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for CEACAM18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEACAM18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.41   Ensembl cytogenetic band:  19q13.41   HGNC cytogenetic band: 19q13.41

CEACAM18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM18 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P051979:  view genomic region     (about GC identifiers)

Start:
51,979,838 bp from pter      End:
51,994,206 bp from pter
Size:
14,369 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CEA18_HUMAN, A8MTB9 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 18 precursor  
Size: 384 amino acids; 43320 Da
Secondary accessions: C9JN24

Explore the universe of human proteins at neXtProt for CEACAM18: NX_A8MTB9

Explore proteomics data for CEACAM18 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn108, Asn112, Asn121, Asn162, Asn270

  • See CEACAM18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001265321.1  
    ENSEMBL proteins: 
     ENSP00000379738   ENSP00000402203  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    4 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom

    Graphical View of Domain Structure for InterPro Entry A8MTB9

    ProtoNet protein and cluster: A8MTB9

    UniProtKB/Swiss-Prot: CEA18_HUMAN, A8MTB9
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    CEACAM18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CEACAM18 for ontologies           About GeneDecksing


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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    plasma membrane2
    endoplasmic reticulum1
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CEACAM18
    Interactions:

        Search GeneGlobe Interaction Network for CEACAM18

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEACAM18 (CEA18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CEACAM18 gene (2 alternative transcripts): 
    NM_001278392.1  NM_001080405.1  

    Unigene Cluster for CEACAM18:

    Carcinoembryonic antigen-related cell adhesion molecule 18
    Hs.653111
    Unigene Representative Sequence: NM_001080405
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000396477 ENST00000451626(uc002pwv.1)
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    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEACAM18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGCACAT
    CEACAM18 Expression
    About this image

    CEACAM18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEACAM18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.653111
        Custom PCR Arrays for CEACAM18
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CEACAM18 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ceacam181 , 5 carcinoembryonic antigen-related cell adhesion molecule more1, 5 71.19(n)1
    61.22(a)1
      7 (28.25 cM)5
    724311  NM_028236.11  NP_082512.11 
     436347395 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    9(a)
    1 → many
    GL344292.1(99-27567)
    zebrafish
    (Danio rerio)
    Actinopterygii ceacam16
    si:dkey-11o1.26
    (see all 8)
    si:dkey-11o1.2
    (see all 8)
    5(a)
    19(a)
    (see all 8)
    many ↔ many
    many ↔ many
    (see all 8)
    16(13474237-13510603) ENSDARG00000041119
    16(13323478-13328414) ENSDARG00000095772


    ENSEMBL Gene Tree for CEACAM18 (if available)
    TreeFam Gene Tree for CEACAM18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEACAM18 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  PSG22  
    CEACAM162  PSG42  CEACAM32  PSG72  
    4 SIMAP similar genes for CEACAM18 using alignment to 1 protein entry:     CEA18_HUMAN:
    CEA    CEACAM1    CEACAM3    CEACAM5

    CEACAM18 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CEACAM18
    PGOHUM00000234374


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEACAM18 (see all 302)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs93047141,2
    C,F,A,H--51977887(+) tcaaaC/Acagac 1 -- us2k15Minor allele frequency- A:0.01NS EA 538
    rs81017771,2
    C,F,A,H--51977891(+) ACCAGA/GCAGTG 1 -- us2k120Minor allele frequency- G:0.18NS EA NA CSA WA 2345
    rs1380173361,2
    C--51977937(+) TCAAA-/CCAGCC 1 -- us2k10--------
    rs93047151,2
    C,F,A--51977965(+) AGCAGT/CCCTCA 1 -- us2k12Minor allele frequency- C:0.03WA EA 238
    rs113910161,2
    C--51977977(+) GGGGGG/-CAGTG 1 -- us2k12Minor allele frequency- -:0.25CSA 4
    rs730496841,2
    C,F--51978105(+) CTCATG/ATTATG 1 -- us2k11Minor allele frequency- A:0.03NA 120
    rs1923929711,2
    --51978219(+) CAGTAC/GAATCA 1 -- us2k10--------
    rs735588331,2
    C,F--51978253(+) CATGAC/TGTGTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1410707891,2
    --51978306(+) GCCTTC/GATGCC 1 -- us2k10--------
    rs93047161,2
    C,F,A,H--51978351(+) ggatgG/Actgtt 1 -- us2k15Minor allele frequency- A:0.01NS EA WA 538

    HapMap Linkage Disequilibrium report for CEACAM18 (51979838 - 51994206 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CEACAM18: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CEACAM18
    DNA2.0 Custom Variant and Variant Library Synthesis for CEACAM18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    CEACAM18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CEACAM18

    Export disorders for CEACAM18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEACAM18 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with CEACAM18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PubMed id 16139472)1 Zebhauser R....Zimmermann W. (Genomics 2005)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 729767 HGNC: 31949 Ensembl:ENSG00000213822 euGenes: HUgn729767 ECgene: CEACAM18
    H-InvDB: CEACAM18

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEACAM18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEACAM18 gene:
    Search GeneIP for patents involving CEACAM18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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     ELISAs for CEACAM18
     CLIAs for CEACAM18



     Browse ESI BIO Cell Lines and PureStem Progenitors for CEACAM18
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM18
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CEACAM18
     Browse SwitchGear Promoter luciferase reporter plasmids for CEACAM18
     Search ThermoFisher Antibodies for CEACAM18
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CEACAM18
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEACAM18
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEACAM18
     LSBio Antibodies in human, mouse, rat for CEACAM18
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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