CEACAM16 Gene
protein-coding GIFtS: 40
GCID: GC19P045202
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carcinoembryonic antigen-related cell adhesion molecule...
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Aliases
for CEACAM16 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Carcinoembryonic Antigen-Related Cell Adhesion Molecule 161 2 | | CEAL22 3 | | DFNA4B2 | | Carcinoembryonic Antigen Like-2 Protein2 | | Carcinoembryonic Antigen-Like 23 |
Export aliases for CEACAM16 gene to outside databasesPrevious GC identifers: GC19P049893 GC19P041634 |
Summaries
for CEACAM16 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CEACAM16:
The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins inthe inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important forproper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomaldominant hearing loss. (provided by RefSeq, May 2012)
UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9Function: May play a role in maintaining the integrity of the tectorial membrane
|
Genomic Views
for CEACAM16 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CEACAM16 gene promoter:
AhR AML1a Pax-5 MyoD Tal-1beta E47 HEN1 PPAR-alpha Pax-4a ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for CEACAM16
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM16 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.32 HGNC cytogenetic band: 19q13.31CEACAM16 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P045202: view genomic region
(about GC identifiers)
Start:
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45,202,421 bp from pter |
End:
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45,213,986 bp from pter |
Size:
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11,566 bases |
Orientation:
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plus strand |
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Proteins
for CEACAM16 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9 (See
protein sequence)Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 16 precursor Size: 425 amino acids; 45873 Da
Subunit: Monomer. Homodimer. Tetramer. Interacts with TECTA
Subcellular location: Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane(By similarity)
Sequence caution: Sequence=AAQ05841.1; Type=Erroneous gene model prediction;
Secondary accessions: A7LI12Explore the universe of human proteins at neXtProt for CEACAM16: NX_Q2WEN9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q2WEN9
CEACAM16 Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001034302.2
ENSEMBL proteins: ENSP00000466561 ENSP00000385576
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0032426 | stereocilium bundle tip |
ISS | -- |
CEACAM16 for ontologies About GeneDecksing
CEACAM16 Antibody Products:
Assay Products for CEACAM16: |
Protein
Domains /
Families
for CEACAM16 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CEACAM16 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q2WEN9ProtoNet protein and cluster: Q2WEN9 UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9Similarity: Belongs to the immunoglobulin superfamily. CEA familySimilarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains |
Function
for CEACAM16 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9Function: May play a role in maintaining the integrity of the tectorial membrane
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM16
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM16 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- |
CEACAM16 for ontologies About GeneDecksing
Animal Models:
Mouse knock-out Ceacam16tm1Wzm for CEACAM16
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Ceacam16):
CEACAM16 for phenotypes About GeneDecksing
|
Pathways & Interactions
for CEACAM16 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM16
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007605 | sensory perception of sound |
IMP | -- |
CEACAM16 for ontologies About GeneDecksing
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Drugs & Compounds
for CEACAM16 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CEACAM16
Search CenterWatch for drugs/clinical trials and news about CEACAM16 / CEA16
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Transcripts
for CEACAM16 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CEACAM16 gene: NM_001039213.2 Unigene Cluster for CEACAM16: Carcinoembryonic antigen-related cell adhesion molecule 16 Hs.456381 [show with all ESTs]Unigene Representative Sequence: NM_0010392132 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000587331 ENST00000405314(uc010xxd.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM16 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM16
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CEACAM16 (NM_001039213) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CEACAM16 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM16 |
Additional cDNA sequence: BC144608.1 EU021223.1 1 DOTS entry: DT.91787861 1 AceView cDNA sequence: BF589367
GeneLoc Exon Structure
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Expression
for CEACAM16 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CEACAM16 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTGCGAAG
About this image
SOURCE GeneReport for Unigene cluster: Hs.456381
SABiosciences Custom PCR Arrays for CEACAM16
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEACAM16
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CEACAM16 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM16 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM16 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM16 |
Orthologs
for CEACAM16 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CEACAM16 gene from 2/9 species (see all 9) About this table
ENSEMBL Gene Tree for CEACAM16 (if available)
TreeFam Gene Tree for CEACAM16 (if available) |
Paralogs
for CEACAM16 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CEACAM16 gene
- PSG92 PSG82 CEACAM42 CEACAM52 PSG112 CEACAM72 PSG32 CEACAM212
- PSG12 PSG52 PSG62 CEACAM12 CEACAM82 PSG22 CEACAM62 CEACAM182
- PSG42 CEACAM32
9 SIMAP similar genes for CEACAM16 using alignment to 1 protein entry: CEA16_HUMAN:CEACAM21 CEACAM6 CEACAM1 CEACAM8 PSG5 PSG6
CEACAM5 PSG11 PSG4
CEACAM16 for paralogs About GeneDecksing
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Genomic Variants
for CEACAM16 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CEACAM16 (45202421 - 45213986 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CEACAM16
2 CNVs: 0221 30910
Human Gene Mutation Database (HGMD): CEACAM16
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CEACAM16 |
|
Disorders
/ Diseases
for CEACAM16 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CEACAM16 for disorders About GeneDecksing
OMIM gene information: 614591
OMIM disorders: --
UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9
Defects in CEACAM16 are the cause of deafness autosomal dominant type 4B (DFNA4B) [MIM:614614]. A form ofsensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, thenerve pathways to the brain, or the area of the brain that receives sound information
3  diseases for CEACAM16: About MalaCardsautosomal dominant nonsyndromic deafness nonsyndromic deafness hearing loss
Export disorders for CEACAM16 gene to outside databases
|
Publications
for CEACAM16 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CEACAM16 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CEACAM16) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Carcinoembryonic antigen-related cell adhesion molecu le 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearin g loss (DFNA4). (PubMed id 21368133)1, 2 Zheng J....Dallos P. (2011)
- Loss of mammal-specific tectorial membrane component c arcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing im pairment at low and high frequencies. (PubMed id 22544735)1 Kammerer R....Zimmermann W. (2012)
- Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PubMed id 16139472)1 Zebhauser R....Zimmermann W. (2005)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for CEACAM16 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CEACAM16 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CEACAM16 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CEACAM16 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CEACAM16 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CEACAM16 gene:
Search GeneIP for patents involving CEACAM16
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CEACAM16 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | CEACAM16 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM16 |
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