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Aliases for CEACAM16 Gene

Aliases for CEACAM16 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16 2 3
  • CEAL2 3 4 6
  • DFNA4B 3 6
  • Carcinoembryonic Antigen Like-2 Protein 3
  • Carcinoembryonic Antigen-Like 2 4

External Ids for CEACAM16 Gene

Previous GeneCards Identifiers for CEACAM16 Gene

  • GC19P049893
  • GC19P045202
  • GC19P041634

Summaries for CEACAM16 Gene

Entrez Gene Summary for CEACAM16 Gene

  • The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]

GeneCards Summary for CEACAM16 Gene

CEACAM16 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16) is a Protein Coding gene. Diseases associated with CEACAM16 include deafness, autosomal dominant 4b and autosomal dominant non-syndromic sensorineural deafness type dfna. An important paralog of this gene is CEACAM8.

UniProtKB/Swiss-Prot for CEACAM16 Gene

  • Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM16 Gene

Genomics for CEACAM16 Gene

Regulatory Elements for CEACAM16 Gene

Genomic Location for CEACAM16 Gene

Start:
44,699,151 bp from pter
End:
44,710,714 bp from pter
Size:
11,564 bases
Orientation:
Plus strand

Genomic View for CEACAM16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM16 Gene

Proteins for CEACAM16 Gene

  • Protein details for CEACAM16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2WEN9-CEA16_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 16
    Protein Accession:
    Q2WEN9
    Secondary Accessions:
    • A7LI12

    Protein attributes for CEACAM16 Gene

    Size:
    425 amino acids
    Molecular mass:
    45873 Da
    Quaternary structure:
    • Homooligomer; can for homodimers and homotetramers (PubMed:21368133, PubMed:25589040). Interacts with TECTA (PubMed:21368133).
    SequenceCaution:
    • Sequence=AAQ05841.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CEACAM16 Gene

Proteomics data for CEACAM16 Gene at MOPED

Post-translational modifications for CEACAM16 Gene

  • Glycosylation at Asn36, Asn216, and Asn394
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM16 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CEACAM16 Gene

Domains for CEACAM16 Gene

Gene Families for CEACAM16 Gene

HGNC:
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for CEACAM16 Gene

Suggested Antigen Peptide Sequences for CEACAM16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2WEN9

UniProtKB/Swiss-Prot:

CEA16_HUMAN :
  • Q2WEN9
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM16: view

Function for CEACAM16 Gene

Molecular function for CEACAM16 Gene

UniProtKB/Swiss-Prot Function:
Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.

Gene Ontology (GO) - Molecular Function for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0042802 identical protein binding IDA 25589040
genes like me logo Genes that share ontologies with CEACAM16: view

Phenotypes for CEACAM16 Gene

MGI mutant phenotypes for CEACAM16:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with CEACAM16: view

Animal Models for CEACAM16 Gene

MGI Knock Outs for CEACAM16:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM16

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CEACAM16 Gene

Localization for CEACAM16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM16 Gene

Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane. {ECO:0000250 UniProtKB:E9QA28}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM16 Gene COMPARTMENTS Subcellular localization image for CEACAM16 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
GO:0005615 extracellular space IDA 25589040
GO:0032426 stereocilium bundle tip ISS --
genes like me logo Genes that share ontologies with CEACAM16: view

Pathways for CEACAM16 Gene

SuperPathways for CEACAM16 Gene

No Data Available

Interacting Proteins for CEACAM16 Gene

Gene Ontology (GO) - Biological Process for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IMP 21368133
genes like me logo Genes that share ontologies with CEACAM16: view

No data available for Pathways by source for CEACAM16 Gene

Transcripts for CEACAM16 Gene

mRNA/cDNA for CEACAM16 Gene

(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEACAM16 Gene

Carcinoembryonic antigen-related cell adhesion molecule 16:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CEACAM16

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM16 Gene

No ASD Table

Relevant External Links for CEACAM16 Gene

GeneLoc Exon Structure for
CEACAM16
ECgene alternative splicing isoforms for
CEACAM16

Expression for CEACAM16 Gene

mRNA expression in normal human tissues for CEACAM16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM16 Gene

This gene is overexpressed in Pancreas (13.1), Adrenal Gland (5.9), and Liver (4.8).

SOURCE GeneReport for Unigene cluster for CEACAM16 Gene Hs.456381

genes like me logo Genes that share expressions with CEACAM16: view

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for CEACAM16 Gene

Orthologs for CEACAM16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM16 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CEACAM16 35
  • 87.86 (n)
  • 89.08 (a)
CEACAM16 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CEACAM16 35
  • 89.44 (n)
  • 91.02 (a)
CEACAM16 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ceacam16 35
  • 83.22 (n)
  • 89.83 (a)
Ceacam16 16
Ceacam16 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CEACAM16 35
  • 99.53 (n)
  • 99.76 (a)
CEACAM16 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ceacam16 35
  • 84.16 (n)
  • 89.13 (a)
oppossum
(Monodelphis domestica)
Mammalia CEACAM16 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEACAM16 36
  • 22 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 13 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:198329 36
  • 15 (a)
ManyToMany
Species with no ortholog for CEACAM16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEACAM16 Gene

ENSEMBL:
Gene Tree for CEACAM16 (if available)
TreeFam:
Gene Tree for CEACAM16 (if available)

Paralogs for CEACAM16 Gene

Selected SIMAP similar genes for CEACAM16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CEACAM16: view

Variants for CEACAM16 Gene

Sequence variations from dbSNP and Humsavar for CEACAM16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs894189 -- 44,703,425(-) ACCAG(C/T)GTGAC synonymous-codon, reference
rs894190 -- 44,702,428(-) gtcta(A/G)ccctc intron-variant
rs1530268 -- 44,701,028(-) CTGCA(A/C)CTTTC intron-variant
rs2119660 -- 44,699,370(-) ATGGA(A/C)TCTGC intron-variant
rs2165540 -- 44,699,677(-) GCTCA(C/T)ggccg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM16 Gene

Variant ID Type Subtype PubMed ID
nsv483005 CNV Loss 15286789
nsv912116 CNV Loss 21882294
nsv9737 CNV Gain 18304495
nsv833841 CNV Loss 17160897
esv2718627 CNV Deletion 23290073

Relevant External Links for CEACAM16 Gene

HapMap Linkage Disequilibrium report
CEACAM16
Human Gene Mutation Database (HGMD)
CEACAM16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM16 Gene

Disorders for CEACAM16 Gene

(1) OMIM Diseases for CEACAM16 Gene (614591)

UniProtKB/Swiss-Prot

CEA16_HUMAN
  • Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:21368133, ECO:0000269 PubMed:25589040}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CEACAM16

Genetic Association Database (GAD)
CEACAM16
genes like me logo Genes that share disorders with CEACAM16: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for CEACAM16 Gene

Publications for CEACAM16 Gene

  1. Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4). (PMID: 21368133) Zheng J. … Dallos P. (Proc. Natl. Acad. Sci. U.S.A. 2011) 2 3 4
  2. Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family. (PMID: 25589040) Wang H. … Feng Y. (J. Hum. Genet. 2015) 3 4
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. (PMID: 22544735) Kammerer R. … Zimmermann W. (J. Biol. Chem. 2012) 3

Products for CEACAM16 Gene

Sources for CEACAM16 Gene

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