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Aliases for CEACAM16 Gene

Aliases for CEACAM16 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 16 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 16 2 3
  • CEAL2 3 4
  • Carcinoembryonic Antigen Like-2 Protein 3
  • Carcinoembryonic Antigen-Like 2 4
  • DFNA4B 3

External Ids for CEACAM16 Gene

Previous GeneCards Identifiers for CEACAM16 Gene

  • GC19P049893
  • GC19P045202
  • GC19P041634

Summaries for CEACAM16 Gene

Entrez Gene Summary for CEACAM16 Gene

  • The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of non-syndromic autosomal dominant hearing loss. [provided by RefSeq, May 2012]

GeneCards Summary for CEACAM16 Gene

CEACAM16 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 16) is a Protein Coding gene. Diseases associated with CEACAM16 include Deafness, Autosomal Dominant 4B and Dfna 4B Nonsyndromic Hearing Loss And Deafness. GO annotations related to this gene include identical protein binding. An important paralog of this gene is CEACAM1.

UniProtKB/Swiss-Prot for CEACAM16 Gene

  • Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM16 Gene

Genomics for CEACAM16 Gene

Regulatory Elements for CEACAM16 Gene

Enhancers for CEACAM16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F044736 1.3 FANTOM5 ENCODE 12.5 +40.4 40441 3.4 HDGF TBL1XR1 BMI1 RAD21 CHAMP1 RARA YY1 ZNF121 FOS CREM RELB CEACAM16 ENSG00000266903 BCL3 CLASRP BLOC1S3 LOC105372416 ENSG00000252200 GC19M044726
GH19F044734 1.1 Ensembl ENCODE 12.5 +37.7 37659 0.9 TBP ZNF146 SMAD5 JUN GTF2B MAX EP300 ZNF121 GATA3 JUND CEACAM16 FBXO46 BLOC1S3 ENSG00000266958 ZNF180 ZNF230 LOC105372416 GC19M044726 ENSG00000252200
GH19F045081 0.3 FANTOM5 3.9 +384.0 384024 0.0 HDGF ATF1 PKNOX1 MLX CREB3L1 ARID4B SIN3A DMAP1 YY1 ELK1 CEACAM16 NKPD1 MARK4 LOC105372419
GH19F044720 1.1 FANTOM5 Ensembl ENCODE 3.5 +26.0 26041 6.3 ARID4B SIN3A DMAP1 ZNF48 YY1 GATA2 ZNF143 ZNF207 FOS ZNF263 ENSG00000266903 APOE RELB APOC2 CEACAM19 BCL3 CLASRP CEACAM16 IGSF23 APOC4
GH19F044841 0.3 FANTOM5 3.5 +143.9 143879 0.3 ZNF687 MNT CEACAM16 NKPD1 CLASRP NECTIN2 GC19M044733
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CEACAM16 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM16 Gene

Chromosome:
19
Start:
44,697,504 bp from pter
End:
44,710,714 bp from pter
Size:
13,211 bases
Orientation:
Plus strand

Genomic View for CEACAM16 Gene

Genes around CEACAM16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM16 Gene

Proteins for CEACAM16 Gene

  • Protein details for CEACAM16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2WEN9-CEA16_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 16
    Protein Accession:
    Q2WEN9
    Secondary Accessions:
    • A7LI12

    Protein attributes for CEACAM16 Gene

    Size:
    425 amino acids
    Molecular mass:
    45873 Da
    Quaternary structure:
    • Homooligomer; can for homodimers and homotetramers (PubMed:21368133, PubMed:25589040). Interacts with TECTA (PubMed:21368133).
    SequenceCaution:
    • Sequence=AAQ05841.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for CEACAM16 Gene

Post-translational modifications for CEACAM16 Gene

  • Glycosylation at Asn 36, Asn 216, and Asn 394
  • Modification sites at PhosphoSitePlus

Other Protein References for CEACAM16 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CEACAM16 Gene

Domains & Families for CEACAM16 Gene

Protein Domains for CEACAM16 Gene

Suggested Antigen Peptide Sequences for CEACAM16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2WEN9

UniProtKB/Swiss-Prot:

CEA16_HUMAN :
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM16: view

Function for CEACAM16 Gene

Molecular function for CEACAM16 Gene

UniProtKB/Swiss-Prot Function:
Required for proper hearing, it may play a role in maintaining the integrity of the tectorial membrane.

Gene Ontology (GO) - Molecular Function for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IDA 25589040
genes like me logo Genes that share ontologies with CEACAM16: view
genes like me logo Genes that share phenotypes with CEACAM16: view

Human Phenotype Ontology for CEACAM16 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for CEACAM16 Gene

MGI Knock Outs for CEACAM16:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM16 Gene

Localization for CEACAM16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM16 Gene

Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial membrane. {ECO:0000250 UniProtKB:E9QA28}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM16 Gene COMPARTMENTS Subcellular localization image for CEACAM16 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 2
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 25589040
GO:0032426 stereocilium tip ISS --
genes like me logo Genes that share ontologies with CEACAM16: view

Pathways & Interactions for CEACAM16 Gene

SuperPathways for CEACAM16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CEACAM16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007605 sensory perception of sound IMP 21368133
genes like me logo Genes that share ontologies with CEACAM16: view

No data available for Pathways by source and SIGNOR curated interactions for CEACAM16 Gene

Transcripts for CEACAM16 Gene

mRNA/cDNA for CEACAM16 Gene

(2) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CEACAM16 Gene

Carcinoembryonic antigen-related cell adhesion molecule 16:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM16 Gene

No ASD Table

Relevant External Links for CEACAM16 Gene

GeneLoc Exon Structure for
CEACAM16
ECgene alternative splicing isoforms for
CEACAM16

Expression for CEACAM16 Gene

mRNA expression in normal human tissues for CEACAM16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM16 Gene

This gene is overexpressed in Pancreas (x13.1), Adrenal Gland (x5.9), and Liver (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of CEACAM16 Gene:

CEACAM16

SOURCE GeneReport for Unigene cluster for CEACAM16 Gene:

Hs.456381
genes like me logo Genes that share expression patterns with CEACAM16: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CEACAM16 Gene

Orthologs for CEACAM16 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM16 34 35
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia CEACAM16 34 35
  • 89.44 (n)
cow
(Bos Taurus)
Mammalia CEACAM16 34 35
  • 87.86 (n)
rat
(Rattus norvegicus)
Mammalia Ceacam16 34
  • 84.16 (n)
mouse
(Mus musculus)
Mammalia Ceacam16 34 16 35
  • 83.22 (n)
oppossum
(Monodelphis domestica)
Mammalia CEACAM16 35
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CEACAM16 35
  • 22 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 13 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii zgc:198329 35
  • 15 (a)
ManyToMany
Species where no ortholog for CEACAM16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CEACAM16 Gene

ENSEMBL:
Gene Tree for CEACAM16 (if available)
TreeFam:
Gene Tree for CEACAM16 (if available)

Paralogs for CEACAM16 Gene

(10) SIMAP similar genes for CEACAM16 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CEACAM16: view

Variants for CEACAM16 Gene

Sequence variations from dbSNP and Humsavar for CEACAM16 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs387907149 Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614], Pathogenic 44,704,053(+) ACAGC(A/C)CAGCG intron-variant, reference, missense
VAR_072720 Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614]
rs746164064 Pathogenic 44,705,631(+) CCACC(C/T)GCACA intron-variant, reference, missense
rs876661405 Pathogenic 44,704,140(+) ACGGT(A/G)GGGCC intron-variant, reference, missense
rs114645388 Likely benign 44,704,154(+) CCCGT(C/T)GCTCT intron-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for CEACAM16 Gene

Variant ID Type Subtype PubMed ID
esv2718627 CNV deletion 23290073
nsv1062812 CNV gain 25217958
nsv483005 CNV loss 15286789
nsv833841 CNV loss 17160897
nsv9737 CNV gain 18304495

Variation tolerance for CEACAM16 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.82; 34.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM16 Gene

Human Gene Mutation Database (HGMD)
CEACAM16
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM16 Gene

Disorders for CEACAM16 Gene

MalaCards: The human disease database

(4) MalaCards diseases for CEACAM16 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal dominant 4b
  • autosomal dominant nonsyndromic deafness 4b
dfna 4b nonsyndromic hearing loss and deafness
  • deafness, autosomal dominant 4b
autosomal dominant non-syndromic sensorineural deafness type dfna
  • autosomal dominant isolated neurosensory deafness type dfna
autosomal dominant nonsyndromic deafness
  • autosomal dominant deafness
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CEA16_HUMAN
  • Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614]: A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. {ECO:0000269 PubMed:21368133, ECO:0000269 PubMed:25589040}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CEACAM16

Genetic Association Database (GAD)
CEACAM16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM16
genes like me logo Genes that share disorders with CEACAM16: view

No data available for Genatlas for CEACAM16 Gene

Publications for CEACAM16 Gene

  1. Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4). (PMID: 21368133) Zheng J. … Dallos P. (Proc. Natl. Acad. Sci. U.S.A. 2011) 2 3 4 64
  2. Exome sequencing identifies a novel CEACAM16 mutation associated with autosomal dominant nonsyndromic hearing loss DFNA4B in a Chinese family. (PMID: 25589040) Wang H. … Feng Y. (J. Hum. Genet. 2015) 3 4 64
  3. Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma. (PMID: 26497080) Yan L. … Peng J. (Oncol. Rep. 2016) 3 64
  4. SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. (PMID: 23565137) Miyashita A. … Kuwano R. (PLoS ONE 2013) 3 64
  5. Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies. (PMID: 22544735) Kammerer R. … Zimmermann W. (J. Biol. Chem. 2012) 3 64

Products for CEACAM16 Gene

Sources for CEACAM16 Gene

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