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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CEACAM16 Gene

protein-coding   GIFtS: 41
GCID: GC19P045202

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 161 2
CEAL22 3
DFNA4B2
Carcinoembryonic Antigen Like-2 Protein2
Carcinoembryonic Antigen-Like 23

External Ids:    HGNC: 319481   Entrez Gene: 3885512   Ensembl: ENSG000002138927   OMIM: 6145915   UniProtKB: Q2WEN93   

Export aliases for CEACAM16 gene to outside databases

Previous GC identifers: GC19P049893 GC19P041634


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEACAM16 Gene:
The protein encoded by this gene is a secreted glycoprotein that in mouse interacts with tectorial membrane
proteins in the inner ear. The encoded adhesion protein is found in cochlear outer hair cells and appears to be
important for proper hearing over an extended frequency range. Defects in this gene likely are a cause of
non-syndromic autosomal dominant hearing loss. (provided by RefSeq, May 2012)

GeneCards Summary for CEACAM16 Gene: 
CEACAM16 (carcinoembryonic antigen-related cell adhesion molecule 16) is a protein-coding gene. Diseases associated with CEACAM16 include autosomal dominant nonsyndromic deafness, and nonsyndromic deafness. An important paralog of this gene is PSG9.

UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9
Function: May play a role in maintaining the integrity of the tectorial membrane




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CEACAM16 gene promoter:
         AhR   AML1a   Pax-5   MyoD   Tal-1beta   E47   HEN1   PPAR-alpha   Pax-4a   ITF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CEACAM16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.31

CEACAM16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM16 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P045202:  view genomic region     (about GC identifiers)

Start:
45,202,421 bp from pter      End:
45,213,986 bp from pter
Size:
11,566 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 16 precursor  
Size: 425 amino acids; 45873 Da
Subunit: Monomer. Homodimer. Tetramer. Interacts with TECTA
Subcellular location: Secreted. Note=Localizes to the tip of cochlear outer hair cells and to the tectorial
membrane (By similarity)
Sequence caution: Sequence=AAQ05841.1; Type=Erroneous gene model prediction;
Secondary accessions: A7LI12

Explore the universe of human proteins at neXtProt for CEACAM16: NX_Q2WEN9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2WEN9

  • CEACAM16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001034302.2  
    ENSEMBL proteins: 
     ENSP00000466561   ENSP00000385576  

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    Cloud-Clone Corp. Proteins for CEACAM16 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--
    GO:0032426stereocilium bundle tip ISS--

    CEACAM16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    5 InterPro protein domains:
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry Q2WEN9

    ProtoNet protein and cluster: Q2WEN9

    UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 2 Ig-like C2-type (immunoglobulin-like) domains


    CEACAM16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CEA16_HUMAN, Q2WEN9
    Function: May play a role in maintaining the integrity of the tectorial membrane

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    CEACAM16 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Ceacam16):
     hearing/vestibular/ear 

    CEACAM16 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ceacam16tm1Wzm for CEACAM16

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CEACAM16 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CEACAM16

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007605sensory perception of sound IMP--

    CEACAM16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CEACAM16 (CEA16)

    Search CenterWatch for drugs/clinical trials and news about CEACAM16 / CEA16

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CEACAM16 gene: 
    NM_001039213.2  

    Unigene Cluster for CEACAM16:

    Carcinoembryonic antigen-related cell adhesion molecule 16
    Hs.456381  [show with all ESTs]
    Unigene Representative Sequence: NM_001039213
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000587331 ENST00000405314(uc010xxd.2)
    miRNA
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    hsa-miR-942
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC144608.1 EU021223.1 

    1 DOTS entry:

    DT.91787861 

    1 AceView cDNA sequence:

    BF589367 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CEACAM16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTGCGAAG
    CEACAM16 Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.456381
        SABiosciences Custom PCR Arrays for CEACAM16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CEACAM16 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ceacam161 , 5 carcinoembryonic antigen-related cell adhesion molecule more1, 5 83.29(n)1
    89.83(a)1
      7 (9.95 cM)5
    3304831  NM_001033419.21  NP_001028591.21 
     198520975 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    13(a)
    possible ortholog
    GL344292.1(99-27567)
    zebrafish
    (Danio rerio)
    Actinopterygii ceacam16
    si:dkey-250k15.96
    (see all 9)
    si:dkey-250k15.9
    (see all 9)
    5(a)
    19(a)
    (see all 9)
    many ↔ many
    many ↔ many
    (see all 9)
    16(13474237-13510603)
    16(13402598-13403485)


    ENSEMBL Gene Tree for CEACAM16 (if available)
    TreeFam Gene Tree for CEACAM16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CEACAM16 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM12  CEACAM62  CEACAM182  
    PSG22  PSG42  CEACAM32  PSG72  
    10 SIMAP similar genes for CEACAM16 using alignment to 1 protein entry:     CEA16_HUMAN:
    CEACAM21    CEACAM6    CEACAM1    CEACAM8    PSG5    PSG6
    CEACAM5    PSG11    PSG4    PSG9

    CEACAM16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/367 SNPs in CEACAM16 are shown (see all 367)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0677694
    Deafness, autosomal dominant, 4B (DFNA4B)4--see VAR_0677692 T P mis40--------
    rs2008936891,2
    C--41640298(+) AAAAA-/CAACAA 1 -- int10--------
    rs2018595681,2
    C--45208022(+) AAAAA-/ACAACA 1 -- int10--------
    rs578822241,2
    C--45214058(+) TCCTT-/TCCCCC 1 -- ds50010--------
    rs29651631,2
    C,F,A,H--45391057(+) GGCCCA/GGCACG 1 -- us2k113Minor allele frequency- G:0.42NA WA CSA EA 377
    rs1490102851,2
    --45391088(+) TTGATC/GCTCAG 1 -- us2k10--------
    rs581319281,2
    C--45391114(+) GTCAAC/TGTCAT 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1148544861,2
    F--45391126(+) AACACC/TCCCCA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs800008661,2
    C,F--45391165(+) GCCCAC/TAAGAA 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs1441925891,2
    --45391189(+) CTGCGA/CAGCCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CEACAM16 (45202421 - 45213986 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CEACAM16:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718627CNV Deletion23290073
    nsv833841CNV Loss17160897
    nsv912116CNV Loss21882294
    nsv483005CNV Loss15286789
    nsv9737CNV Gain18304495


    Human Gene Mutation Database (HGMD): CEACAM16
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CEACAM16
    DNA2.0 Custom Variant and Variant Library Synthesis for CEACAM16

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614591    OMIM disorders: --

    UniProtKB/Swiss-Prot: CEA16_HUMAN, Q2WEN9
  • Deafness, autosomal dominant, 4B (DFNA4B) [MIM:614614]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 3 diseases for CEACAM16:    About MalaCards
    autosomal dominant nonsyndromic deafness    nonsyndromic deafness    sensorineural hearing loss


    CEACAM16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CEACAM16

    Export disorders for CEACAM16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CEACAM16 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with CEACAM16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Carcinoembryonic antigen-related cell adhesion molecu le 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearin g loss (DFNA4). (PubMed id 21368133)1, 2 Zheng J....Dallos P. (2011)
    2. SORL1 is genetically associated with late-onset Alzhei mer's disease in Japanese, Koreans and Caucasians. (PubMed id 23565137)1 Miyashita A....Kuwano R. (2013)
    3. Loss of mammal-specific tectorial membrane component c arcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing im pairment at low and high frequencies. (PubMed id 22544735)1 Kammerer R....Zimmermann W. (2012)
    4. Identification of a novel group of evolutionarily conserved members within the rapidly diverging murine Cea family. (PubMed id 16139472)1 Zebhauser R....Zimmermann W. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388551 HGNC: 31948 AceView: LOC388551 Ensembl:ENSG00000213892 euGenes: HUgn388551
    ECgene: CEACAM16 H-InvDB: CEACAM16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CEACAM16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CEACAM16 gene:
    Search GeneIP for patents involving CEACAM16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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