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Aliases for CEACAM1 Gene

Aliases for CEACAM1 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 2 3
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein) 2 3 5
  • CD66a Antigen 3 4
  • BGP1 3 4
  • BGP 3 4
  • Biliary Glycoprotein 1 4
  • Antigen CD66 3
  • BGP-1 4
  • BGPI 3

External Ids for CEACAM1 Gene

Previous HGNC Symbols for CEACAM1 Gene

  • BGP

Previous GeneCards Identifiers for CEACAM1 Gene

  • GC19M043658
  • GC19M043403
  • GC19M047687
  • GC19M047703
  • GC19M043009
  • GC19M039441

Summaries for CEACAM1 Gene

Entrez Gene Summary for CEACAM1 Gene

  • This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

GeneCards Summary for CEACAM1 Gene

CEACAM1 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CEACAM1 include colorectal cancer. Among its related pathways are Platelet activation, signaling and aggregation and Degradation of the extracellular matrix. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CEACAM8.

Gene Wiki entry for CEACAM1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM1 Gene

Genomics for CEACAM1 Gene

Regulatory Elements for CEACAM1 Gene

Promoters for CEACAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CEACAM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM1 Gene

Chromosome:
19
Start:
42,507,304 bp from pter
End:
42,561,234 bp from pter
Size:
53,931 bases
Orientation:
Minus strand

Genomic View for CEACAM1 Gene

Genes around CEACAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM1 Gene

Proteins for CEACAM1 Gene

  • Protein details for CEACAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13688-CEAM1_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 1
    Protein Accession:
    P13688
    Secondary Accessions:
    • A6NE38
    • A8MY49
    • O60430
    • Q069I7
    • Q13854
    • Q13857
    • Q13858
    • Q13859
    • Q13860
    • Q15600
    • Q15601
    • Q16170
    • Q5UB49
    • Q7KYP5
    • Q96CA7
    • Q9UQV9

    Protein attributes for CEACAM1 Gene

    Size:
    526 amino acids
    Molecular mass:
    57560 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA57141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEACAM1 Gene

    Alternative splice isoforms for CEACAM1 Gene

neXtProt entry for CEACAM1 Gene

Proteomics data for CEACAM1 Gene at MOPED

Post-translational modifications for CEACAM1 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 115, Asn 152, Asn 182, Asn 197, Asn 208, Asn 224, Asn 232, Asn 254, Asn 274, Asn 288, Asn 292, Asn 302, Asn 309, Asn 345, Asn 351, Asn 363, Asn 378, and Asn 405
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CEACAM1 (CEACAM-1/CD66a)
  • Cell Signaling Technology (CST) Antibodies for CEACAM1 (CEACAM1)

No data available for DME Specific Peptides for CEACAM1 Gene

Domains & Families for CEACAM1 Gene

Suggested Antigen Peptide Sequences for CEACAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13688

UniProtKB/Swiss-Prot:

CEAM1_HUMAN :
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM1: view

Function for CEACAM1 Gene

Molecular function for CEACAM1 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 1,biliary glycoprotein (see CEA@)
genes like me logo Genes that share phenotypes with CEACAM1: view

Animal Models for CEACAM1 Gene

MGI Knock Outs for CEACAM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM1 Gene

Localization for CEACAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Cell membrane; Single-pass type I membrane protein.
Isoform 6: Cell membrane; Single-pass type I membrane protein.
Isoform 7: Cell membrane; Single-pass type I membrane protein.
Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of cell-cell contact.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM1 Gene COMPARTMENTS Subcellular localization image for CEACAM1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
endosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005911 cell-cell junction IDA 16291724
GO:0016324 apical plasma membrane ISS --
genes like me logo Genes that share ontologies with CEACAM1: view

Pathways & Interactions for CEACAM1 Gene

genes like me logo Genes that share pathways with CEACAM1: view

Pathways by source for CEACAM1 Gene

SIGNOR curated interactions for CEACAM1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 15687237
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules NAS 15687237
GO:0016477 cell migration NAS 15687237
GO:0050860 negative regulation of T cell receptor signaling pathway IDA 18424730
genes like me logo Genes that share ontologies with CEACAM1: view

Drugs & Compounds for CEACAM1 Gene

(9) Drugs for CEACAM1 Gene - From: Novoseek, DGIdb, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arcitumomab Approved, Investigational Pharma antibody, Target, other/unknown 0
CEA-Scan Approved April 1996 Pharma 0

(12) Additional Compounds for CEACAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM1: view

Transcripts for CEACAM1 Gene

Unigene Clusters for CEACAM1 Gene

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM1 Gene

No ASD Table

Relevant External Links for CEACAM1 Gene

GeneLoc Exon Structure for
CEACAM1
ECgene alternative splicing isoforms for
CEACAM1

Expression for CEACAM1 Gene

mRNA expression in normal human tissues for CEACAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM1 Gene

This gene is overexpressed in Colon - Transverse (x13.7), Whole Blood (x7.2), Esophagus - Mucosa (x5.6), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for CEACAM1 Gene

This gene is overexpressed in Neutrophil (30.8) and Nasal epithelium (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEACAM1 Gene



SOURCE GeneReport for Unigene cluster for CEACAM1 Gene Hs.512682

genes like me logo Genes that share expression patterns with CEACAM1: view

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CEACAM1 Gene

Orthologs for CEACAM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM1 35
  • 98.77 (n)
  • 97.6 (a)
CEACAM1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 34 (a)
ManyToMany
CEACAM1 36
  • 58 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CEACAM8 35
  • 77.22 (n)
  • 63.64 (a)
mouse
(Mus musculus)
Mammalia Ceacam1 35
  • 72.19 (n)
  • 58 (a)
Ceacam2 16
Psg25 36
  • 27 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ceacam1 35
  • 70.65 (n)
  • 55.88 (a)
Species with no ortholog for CEACAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM1 Gene

ENSEMBL:
Gene Tree for CEACAM1 (if available)
TreeFam:
Gene Tree for CEACAM1 (if available)

Paralogs for CEACAM1 Gene

genes like me logo Genes that share paralogs with CEACAM1: view

Variants for CEACAM1 Gene

Sequence variations from dbSNP and Humsavar for CEACAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_049844 -
VAR_049845 -
VAR_049846 -
VAR_049847 -

Structural Variations from Database of Genomic Variants (DGV) for CEACAM1 Gene

Variant ID Type Subtype PubMed ID
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639

Variation tolerance for CEACAM1 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM1 Gene

HapMap Linkage Disequilibrium report
CEACAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM1 Gene

Disorders for CEACAM1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CEACAM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CEACAM1

Genetic Association Database (GAD)
CEACAM1
Human Genome Epidemiology (HuGE) Navigator
CEACAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM1
genes like me logo Genes that share disorders with CEACAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM1 Gene

Publications for CEACAM1 Gene

  1. Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library. (PMID: 2025273) Kuroki M. … Matsuoka Y. (Biochem. Biophys. Res. Commun. 1991) 2 3 4 67
  2. DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools. (PMID: 20034698) Samsen A. … Wagener C. (Eur. J. Cell Biol. 2010) 3 23
  3. CEACAM1 recognition by bacterial pathogens is species-specific. (PMID: 20406467) Voges M. … Hauck C.R. (BMC Microbiol. 2010) 3 23
  4. The different expression of carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) and possible roles in gastric carcinomas. (PMID: 19243897) Zhou C.J. … Guo J.Q. (Pathol. Res. Pract. 2009) 3 23
  5. Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner. (PMID: 19454653) Lobo E.O. … Shively J.E. (J. Leukoc. Biol. 2009) 3 23

Products for CEACAM1 Gene

Sources for CEACAM1 Gene

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