Aliases for CEACAM1 Gene
External Ids for CEACAM1 Gene
Previous HGNC Symbols for CEACAM1 Gene
Previous GeneCards Identifiers for CEACAM1 Gene
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]
GeneCards Summary for CEACAM1 Gene
CEACAM1 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CEACAM1 include Colorectal Cancer and Microinvasive Gastric Cancer. Among its related pathways are NF-kappaB Signaling and Platelet activation, signaling and aggregation. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CEACAM8.