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CEACAM1 Gene

protein-coding   GIFtS: 65
GCID: GC19M043009

Carcinoembryonic Antigen-Related Cell Adhesion Molecule...


(Previous symbol: BGP)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary
Glycoprotein)1 2
     Antigen CD662
BGP1 2 3 5     Carcinoembryonic Antigen-Related Cell Adhesion Molecule 12
BGP12 3     BGP-13
CD66a Antigen2 3     Biliary Glycoprotein 13
BGPI2     

External Ids:    HGNC: 18141   Entrez Gene: 6342   Ensembl: ENSG000000793857   OMIM: 1097705   UniProtKB: P136883   

Export aliases for CEACAM1 gene to outside databases

Previous GC identifers: GC19M043658 GC19M043403 GC19M047687 GC19M047703 GC19M039441


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CEACAM1 Gene:
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin
superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific
glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the
CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described
in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule
detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as
well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed
to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional
structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive
immune responses. Multiple transcript variants encoding different isoforms have been reported, but the
full-length nature of all variants has not been defined. (provided by RefSeq, May 2010)

GeneCards Summary for CEACAM1 Gene:
CEACAM1 (carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)) is a protein-coding gene. Diseases associated with CEACAM1 include gonorrhea, and obstructive jaundice. An important paralog of this gene is PSG9.

Gene Wiki entry for CEACAM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the CEACAM1 gene promoter:
         C/EBPbeta   GCNF   GCNF-1   NRSF form 1   c-Myb   GCNF-2   ITF-2   Tal-1beta   NRSF form 2   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CEACAM1 promoter sequence
   Search Chromatin IP Primers for CEACAM1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CEACAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2   Ensembl cytogenetic band:  19q13.2   HGNC cytogenetic band: 19q13.2

CEACAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M043009:  view genomic region     (about GC identifiers)

Start:
43,011,456 bp from pter      End:
43,065,386 bp from pter
Size:
53,931 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CEAM1_HUMAN, P13688 (See protein sequence)
Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 1 precursor  
Size: 526 amino acids; 57560 Da
Sequence caution: Sequence=AAA57141.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for CEACAM1:
2GK2 (3D)    
Secondary accessions: A6NE38 A8MY49 O60430 Q069I7 Q13854 Q13857 Q13858 Q13859 Q13860 Q15600
Q15601 Q16170 Q5UB49 Q7KYP5 Q96CA7 Q9UQV9
Alternative splicing: 11 isoforms:  P13688-1   P13688-2   P13688-3   P13688-4   P13688-5   P13688-6   P13688-7   P13688-8   
P13688-9   P13688-10   P13688-11   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEACAM1: NX_P13688

Explore proteomics data for CEACAM1 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn104, Asn111, Asn115, Asn152, Asn182, Asn197, Asn208, Asn224, Asn232, Asn254,
                                 Asn274, Asn288, Asn292, Asn302, Asn309, Asn345, Asn351, Asn363, Asn378, Asn405
  • Modification sites at PhosphoSitePlus

  • See CEACAM1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001020083.1  NP_001171742.1  NP_001171744.1  NP_001171745.1  NP_001192273.1  NP_001703.2  

    ENSEMBL proteins: 
     ENSP00000244291   ENSP00000161559   ENSP00000384709   ENSP00000384083   ENSP00000351165  
     ENSP00000471918   ENSP00000471566   ENSP00000472633   ENSP00000325946   ENSP00000312184  

    CEACAM1 Human Recombinant Protein Products:

    EMD Millipore Purified and/or Recombinant CEACAM1 Protein
    R&D Systems Recombinant & Natural Proteins for CEACAM1 (CEACAM-1/CD66a)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CEACAM1
    OriGene Protein Over-expression Lysate for CEACAM1
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CEACAM1
    GenScript Custom Purified and Recombinant Proteins Services for CEACAM1
    Novus Biologicals CEACAM1 Proteins
    Novus Biologicals CEACAM1 Lysates
    Sino Biological Recombinant Protein for CEACAM1
    Sino Biological Cell Lysate for CEACAM1
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CEACAM1

    CEACAM1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CEACAM1
    R&D Systems Antibodies for CEACAM1 (CEACAM-1/CD66a)
    Cell Signaling Technology (CST) Antibodies for CEACAM1 
    OriGene Antibodies for CEACAM1
    OriGene Custom Antibody Services for CEACAM1
    Novus Biologicals CEACAM1 Antibodies
    Abcam antibodies for CEACAM1 (P40199, P13688)
    Cloud-Clone Corp. Antibodies for CEACAM1
    ThermoFisher Antibodies for CEACAM1
    LSBio Antibodies in human, mouse, rat for CEACAM1

    CEACAM1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CEACAM1
    R&D Systems ELISAs for CEACAM1 (CEACAM-1/CD66a)         (see all)
    GenScript Custom Assay Services for CEACAM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CEACAM1
    Cloud-Clone Corp. CLIAs for CEACAM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing
    VSET: Immunoglobulin superfamily / V-set domain containing

    Selected InterPro protein domains (see all 6):
     IPR003598 Ig_sub2
     IPR013783 Ig-like_fold
     IPR013106 Ig_V-set
     IPR007110 Ig-like_dom
     IPR003599 Ig_sub

    Graphical View of Domain Structure for InterPro Entry P13688

    ProtoNet protein and cluster: P13688

    2 Blocks protein domains:
    IPB003598 Immunoglobulin C-2 type
    IPB013106 Immunoglobulin V-set


    UniProtKB/Swiss-Prot: CEAM1_HUMAN, P13688
    Similarity: Belongs to the immunoglobulin superfamily. CEA family
    Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains
    Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain


    CEACAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for CEACAM1:
    carcinoembryonic antigen-related cell adhesion molecule 1,biliary glycoprotein (see CEA@)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding IPI18497748
         
    CEACAM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CEACAM1:
     Synthetic lethal with imatinib 

         6 MGI mutant phenotypes (inferred from 6 alleles(MGI details for Ceacam1):
     digestive/alimentary  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     tumorigenesis 

    CEACAM1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CEACAM1: Ceacam1tm1Bcn Ceacam1tm2Bcn

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CEACAM1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CEACAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CEACAM1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CEACAM1

    miRNA
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    Block miRNA regulation of human, mouse, rat CEACAM1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CEACAM1 (see all 18):
    hsa-miR-485-5p hsa-miR-30c hsa-miR-323b-3p hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-340 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCEACAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CEACAM1
    Predesigned siRNA for gene silencing in human, mouse, rat CEACAM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CEACAM1

    Clone
    Products:
         
    OriGene clones in human, mouse for CEACAM1 (see all 29)
    OriGene ORF clones in mouse, rat for CEACAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CEACAM1 (NM_001712)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CEACAM1
    Browse ESI BIO Cell Lines and PureStem Progenitors for CEACAM1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CEAM1_HUMAN, P13688: Isoform 1: Cell membrane; Single-pass type I membrane protein
    CEAM1_HUMAN, P13688: Isoform 2: Secreted
    CEAM1_HUMAN, P13688: Isoform 3: Secreted
    CEAM1_HUMAN, P13688: Isoform 4: Secreted
    CEAM1_HUMAN, P13688: Isoform 5: Cell membrane; Single-pass type I membrane protein
    CEAM1_HUMAN, P13688: Isoform 6: Cell membrane; Single-pass type I membrane protein
    CEAM1_HUMAN, P13688: Isoform 7: Cell membrane; Single-pass type I membrane protein
    CEAM1_HUMAN, P13688: Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of
    cell-cell contact
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane5
    cytoskeleton1
    endosome1
    mitochondrion1
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----
    GO:0005886plasma membrane TAS--
    GO:0005887integral component of plasma membrane NAS15687237
    GO:0016020membrane TAS2457922
    GO:0016021integral component of membrane IDA11994468

    CEACAM1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CEACAM1 About    
    See pathways by source

    SuperPathContained pathways About
    1Lymphocyte Signaling
    Lymphocyte Signaling
    2EGFR1 Signaling Pathway
    EGFR1 Signaling Pathway
    3Adhesion
    Adhesion

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for CEACAM1
        Lymphocyte Signaling
    Adhesion

    1 BioSystems Pathway for CEACAM1
        EGFR1 Signaling Pathway




    CEACAM1 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including CEACAM1: 
              Diabetes in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CEACAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for CEACAM1 (P136881, 2, 3 ENSP000001615594) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    uspa1Q8GH871, 2EBI-4314481,EBI-7936357 MINT-6798525 MINT-6798548 MINT-6798675 MINT-6798537 MINT-6798654 MINT-6798612 MINT-6798709 MINT-6798599 MINT-6798586 MINT-6798566 MINT-6798690 MINT-6798724
    CLEC4MQ9H2X32, 3, ENSP000003162284MINT-72826 MINT-72821 I2D: score=1 STRING: ENSP00000316228
    SHC1P293532, 3, ENSP000004013034MINT-8031984 I2D: score=4 STRING: ENSP00000401303
    CEACAM6P401991, 3, ENSP000001997644EBI-4314481,EBI-4314501 I2D: score=1 STRING: ENSP00000199764
    PTPN11Q061243, ENSP000003409444I2D: score=5 STRING: ENSP00000340944
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001525angiogenesis NAS15687237
    GO:0007156homophilic cell adhesion NAS15687237
    GO:0007229integrin-mediated signaling pathway NAS15687237
    GO:0016477cell migration NAS15687237

    CEACAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CEACAM1 (CEAM1)

    2 DrugBank Compounds for CEACAM1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Arcitumomabanti-Carcinoembryonic Antigen Monoclonal Antibody Fab' Fragment (see all 2)154361-48-5targetother/unknown9389396 12865871
    Alpha-D-Mannose-- 3458-28-4target--10592235

    Selected Novoseek inferred chemical compound relationships for CEACAM1 gene (see all 19)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    matrigel 45.4 14 19285068 (3), 10564638 (3), 15339048 (2), 14522961 (1) (see all 6)
    glycogen 27.1 11 12378338 (1), 10638593 (1), 11384100 (1), 9583890 (1) (see all 7)
    sialic acid 27 1 11322763 (1)
    phosphatidylinositol 19.1 8 17071610 (3), 12571236 (2)
    tyrosine 18.3 15 15004154 (2), 17761831 (2), 9867848 (1), 18453603 (1) (see all 9)
    polysaccharide 11.9 4 20034698 (2), 16282604 (1)
    vegf 11 15 11082271 (3), 15536067 (2), 17310502 (2), 19285068 (2) (see all 6)
    retinoic acid 10.6 7 15364113 (4), 18552205 (2), 8609714 (1)
    glucose 2.39 1 17393985 (1)
    imatinib 0.461 1 14712293 (1)



    CEACAM1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CEACAM1 gene (6 alternative transcripts): 
    NM_001024912.2  NM_001184813.1  NM_001184815.1  NM_001184816.1  NM_001205344.1  NM_001712.4  

    Unigene Cluster for CEACAM1:

    Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
    Hs.512682  [show with all ESTs]
    Unigene Representative Sequence: NM_001712
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000352591 ENST00000161559(uc002otv.3 uc010eij.3 uc002otw.3 uc002oty.3 uc002otz.3 uc010eik.3)
    ENST00000403444 ENST00000403461 ENST00000488639 ENST00000358394(uc010eii.3 uc002otx.3)
    ENST00000465051 ENST00000599389 ENST00000485605 ENST00000344391 ENST00000377806(uc002oua.3 uc002oub.3)
    ENST00000403136(uc002ouc.3) ENST00000600172 ENST00000471298 ENST00000351134
    ENST00000308072
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CEACAM1 (see all 18):
    hsa-miR-485-5p hsa-miR-30c hsa-miR-323b-3p hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-340 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidCEACAM1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CEACAM1
    Predesigned siRNA for gene silencing in human, mouse, rat CEACAM1
    Clone
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    OriGene ORF clones in mouse, rat for CEACAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 6): CEACAM1 (NM_001712)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CEACAM1
      QuantiTect SYBR Green Assays in human, mouse, rat CEACAM1
      QuantiFast Probe-based Assays in human, mouse, rat CEACAM1

    Additional mRNA sequence: 

    AK314211.1 AL833584.1 AY766113.1 BC014473.1 BC024164.1 D12502.1 D90311.1 D90312.1 
    D90313.1 J03858.1 M69176.1 M72238.1 M76742.1 M76743.1 M76744.1 S71326.1 
    S74647.1 X14831.1 X16354.1 X16356.1 

    21 DOTS entries:

    DT.95146984  DT.100658676  DT.92439258  DT.91978573  DT.121424607  DT.91781689  DT.92439264  DT.100822614 
    DT.121424012  DT.65286356  DT.95293755  DT.100822610  DT.86848472  DT.92420006  DT.121424282  DT.121424528 
    DT.40114371  DT.100712890  DT.75132501  DT.91714653  DT.95147024 

    Selected AceView cDNA sequences (see all 202):

    AL601428 BX396085 AI308767 AW951862 AA337247 X16356 BU195866 AW611749 
    AI346459 BC014473 AA593076 AW027805 CR608576 AI291145 AW852192 AI738994 
    BM471072 AW450228 BM021280 AI285093 M76742 BQ426095 BI966253 BF000355 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CEACAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CEACAM1 Expression
    About this image


    CEACAM1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Neutrophils Peripheral Blood
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Extravillous Cytotrophoblast Cells Extravillous Cytotrophoblast Layer
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Dermis (Integumentary System)
    CEACAM1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CEACAM1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.512682
        Pathway & Disease-focused RT2 Profiler PCR Array including CEACAM1: 
              Diabetes in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CEACAM1
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CEACAM1
    QuantiTect SYBR Green Assays in human, mouse, rat CEACAM1
    QuantiFast Probe-based Assays in human, mouse, rat CEACAM1
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for CEACAM1 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ceacam11 , 5 carcinoembryonic antigen-related cell adhesion molecule more1, 5 72.19(n)1
    58(a)1
      7 (13.84 cM)5
    263651  NM_001039185.11  NP_001034274.11 
     254617025 


    ENSEMBL Gene Tree for CEACAM1 (if available)
    TreeFam Gene Tree for CEACAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CEACAM1 gene
    PSG92  PSG82  CEACAM42  CEACAM52  PSG112  PSG32  CEACAM72  CEACAM212  
    PSG12  PSG52  PSG62  ENSG000002678812  CEACAM82  CEACAM62  CEACAM182  PSG22  
    CEACAM162  PSG42  PSG72  CEACAM32  
    Selected SIMAP similar genes for CEACAM1 using alignment to 5 protein entries:     CEAM1_HUMAN (see all proteins) (see all similar genes):
    CEACAM6    CEACAM3    CEACAM7    CEACAM8    CEA    CEACAM5
    OK/SW-cl.41    DHFRP2    PSG    PSG11    PSGII    CEACAM4
    PSG2    PSG1    CEACAM21    PSG5    PSG4    PSG9

    CEACAM1 for paralogs           About GeneDecksing


    5 Pseudogenes.org Pseudogenes for CEACAM1
    PGOHUM00000234325 PGOHUM00000234329 PGOHUM00000234351 PGOHUM00000250581 PGOHUM00000250610


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CEACAM1 (see all 485)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1858411451,2
    --43201265(+) CTGTTA/GCTCCC 6 -- ds50010--------
    rs1903039971,2
    --43201416(+) CAAGGC/TGGGCG 6 -- ds50010--------
    rs347528801,2
    C--43201648(+) GTCTC-/AAAAAA 6 -- ds50010--------
    rs414055501,2
    C,F--43201713(-) TTTCTC/TTACAG 6 -- ds50012Minor allele frequency- T:0.02NS 90
    rs1877211421,2
    --43201732(+) CCAAGG/TTAGTA 6 -- ds50010--------
    rs1910829951,2
    C--43201734(+) AAGGTA/GGTATC 6 -- ds50010--------
    rs1404918461,2
    C--43201919(+) GTACCA/TGAGTA 6 -- ut310--------
    rs1824498151,2
    --43201966(+) CTTAGG/TCCTAA 6 -- ut310--------
    rs116702421,2
    H--43201968(+) TAGGCC/GTAACA 6 -- ut31 ese34Minor allele frequency- G:0.00NS EA 418
    rs115413091,2
    C--43202002(+) ATAAAA/CCCTTT 6 -- ut311Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CEACAM1 (43011456 - 43065386 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for CEACAM1:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv15e196CNV Deletion17116639
    esv2422471CNV Deletion17116639
    nsv526186CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 109770    OMIM disorders: --

    Selected diseases for CEACAM1 (see all 42):    
    About MalaCards
    gonorrhea    obstructive jaundice    adenomatoid tumor    cutaneous malignant melanoma
    oral lichen planus    pancreatic endocrine tumors    endometrial carcinoma    lichen planus
    cushing's syndrome    primary biliary cirrhosis    choriocarcinoma    epididymitis
    hemangioma    hepatoblastoma    lung adenocarcinoma    thyroid cancer
    oral squamous cell carcinoma    hepatocellular carcinoma    esophageal squamous cell carcinoma    cervicitis

    1 disease from the University of Copenhagen DISEASES database for CEACAM1:
    Gonorrhea

    CEACAM1 for disorders           About GeneDecksing

    Selected Novoseek inferred disease relationships for CEACAM1 gene (see all 48)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    endometrial neoplasia 53.8 1 16633066 (1)
    colon carcinoma 47.3 2 1815506 (1), 9028835 (1)
    carcinoma 46.4 74 12469186 (7), 19442569 (4), 11480789 (4), 19243897 (4) (see all 22)
    colon tumor 44.6 4 18927117 (1), 11278391 (1), 18507857 (1), 8402684 (1)
    tumors 43.2 126 17057731 (8), 12122002 (5), 15568039 (5), 15952183 (5) (see all 55)
    gastrointestinal carcinoma 41.6 1 8188529 (1)
    colorectal carcinoma 40.5 13 10638593 (5), 10374690 (2), 7504281 (1), 17057731 (1) (see all 6)
    adenoma 34.2 12 10638593 (2), 10374690 (2), 15476270 (2), 9858884 (1) (see all 7)
    colon cancer 33.9 11 9858884 (2), 15568039 (2), 9028835 (1), 18278069 (1) (see all 6)
    gastric carcinoma 31.5 7 10374690 (2), 11480789 (2), 19243897 (2), 10638593 (1)

    Genetic Association Database (GAD): CEACAM1
    Human Genome Epidemiology (HuGE) Navigator: CEACAM1 (3 documents)

    Export disorders for CEACAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CEACAM1 gene, integrated from 10 sources (see all 304):
    (articles sorted by number of sources associating them with CEACAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library. (PubMed id 2025273)1, 2, 3 Kuroki M.... Matsuoka Y. (Biochem. Biophys. Res. Commun. 1991)
    2. Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. (PubMed id 2457922)1, 2, 3 Hinoda Y.... Paxton R.J. (Proc. Natl. Acad. Sci. U.S.A. 1988)
    3. Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene. (PubMed id 7628460)1, 2, 9 Nedellec P.... Beauchemin N. (Eur. J. Biochem. 1995)
    4. Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. (PubMed id 8055923)1, 2, 9 Hauck W....Beauchemin N. (Eur. J. Biochem. 1994)
    5. Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae. (PubMed id 16929097)1, 2, 9 Fedarovich A.... Davies C. (Acta Crystallogr. D 2006)
    6. Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins. (PubMed id 8423792)1, 2, 9 Barnett T.R.... Pickle W. II (Mol. Cell. Biol. 1993)
    7. ACE gene insertion/deletion polymorphism among patients with type 2 diabetes, and its relationship with metabolic syndrome at Sardjito Hospital Yogyakarta, Indonesia. (PubMed id 20305326)1, 4 Sinorita H....Asdie A.H. (Acta Med Indones 2010)
    8. Haplotypic diversity in human CEACAM genes: effects on susceptibility to meningococcal disease. (PubMed id 17960155)1, 4 Callaghan M.J....Pollard A.J. (Genes Immun. 2008)
    9. Bone mineral density and five prominent candidate genes in Chinese men: associations, interaction effects and their implications. (PubMed id 15917161)1, 4 Lei S.F....Deng H.W. (Maturitas 2005)
    10. Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (J. Proteome Res. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 634 HGNC: 1814 AceView: CEACAM1 Ensembl:ENSG00000079385 euGenes: HUgn634
    ECgene: CEACAM1 H-InvDB: CEACAM1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CEACAM1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CEACAM1 Genetics and Cytogenetics in Oncology and Haematology
    SeattleSNPshttp://pga.gs.washington.edu/data/ceacam1/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CEACAM1 gene:
    Search GeneIP for patents involving CEACAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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