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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CEACAM1 Gene

protein-coding GIFtS: 65
GCID: GC19M043009

carcinoembryonic antigen-related cell adhesion molecule...

(Previous symbol: BGP)

Explore 53 diseases affiliated with
CEACAM1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein)¹ ²		BGPI²
BGP¹ ² ³ ⁵		Antigen CD66²
BGP1¹ ² ³		Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1²
CD66a Antigen² ³		BGP-1³
CD66a¹		Biliary Glycoprotein 1³

External Ids:	HGNC: 1814¹	Entrez Gene: 634²	Ensembl: ENSG00000079385⁷	OMIM: 109770⁵	UniProtKB: P13688³

Export aliases for CEACAM1 gene to outside databases

Previous GC identifers: GC19M043658 GC19M043403 GC19M047687 GC19M047703 GC19M039441

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CEACAM1:

This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin

superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific

glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA

cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile

ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on

leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as

heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the

encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure,

angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses.

Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all

variants has not been defined. (provided by RefSeq, May 2010)

Gene Wiki entry for CEACAM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CEACAM1 gene promoter:
C/EBPbeta GCNF GCNF-1 NRSF form 1 c-Myb GCNF-2 ITF-2 Tal-1beta NRSF form 2 YY1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CEACAM1 promoter sequence

Search SABiosciences Chromatin IP Primers for CEACAM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CEACAM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.2 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.2

CEACAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CEACAM1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M043009: view genomic region (about GC identifiers)

Start:	43,011,458 bp from pter	End:	43,032,661 bp from pter
Size:	21,204 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CEAM1_HUMAN, P13688 (See protein sequence)

Recommended Name: Carcinoembryonic antigen-related cell adhesion molecule 1 precursor

Size: 526 amino acids; 57560 Da

Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 2: Secreted

Subcellular location: Isoform 3: Secreted

Subcellular location: Isoform 4: Secreted

Subcellular location: Isoform 5: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 6: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 7: Cell membrane; Single-pass type I membrane protein

Subcellular location: Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of

cell-cell contact

Sequence caution: Sequence=AAA57141.1; Type=Erroneous gene model prediction;

1 PDB 3D structure from and Proteopedia for CEACAM1:

2GK2 (3D)

Secondary accessions: A6NE38 A8MY49 O60430 Q069I7 Q13854 Q13857 Q13858 Q13859 Q13860 Q15600 Q15601

Q16170 Q5UB49 Q7KYP5 Q96CA7 Q9UQV9

Alternative splicing: 11 isoforms: P13688-1 P13688-2 P13688-3 P13688-4 P13688-5 P13688-6 P13688-7 P13688-8

P13688-9 P13688-10 P13688-11 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CEACAM1: NX_P13688

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P13688

CEACAM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (6 alternative transcripts):

NP_001020083.1 NP_001171742.1 NP_001171744.1 NP_001171745.1 NP_001192273.1 NP_001703.2

ENSEMBL proteins:

ENSP00000161559 ENSP00000384709 ENSP00000384083 ENSP00000367037 ENSP00000341688

ENSP00000384843 ENSP00000351165 ENSP00000325946 ENSP00000244291 ENSP00000312184

Human Recombinant Protein Products:

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	OriGene Purified Protein: CEACAM1 OriGene Protein Over-expression Lysate (see all 2): CEACAM1 OriGene Custom Protein Services for CEACAM1
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	Novus Biologicals CEACAM1 Proteins Novus Biologicals CEACAM1 Lysates
	Sino Biological Recombinant Protein for CEACAM1
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CEACAM1

Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005624	membrane fraction	--	--
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	NAS	15687237
GO:0016020	membrane	TAS	2457922

CEACAM1 for ontologies About GeneDecksing

CEACAM1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CEACAM1
	R&D Systems Antibodies for CEACAM1 (CEACAM-1/CD66a)
	Cell Signaling Technology (CST) Antibodies for CEACAM1
	OriGene Antibodies (see all 2): CEACAM1 OriGene Custom Antibody Services for CEACAM1
	GenScript Custom Superior Antibodies Services for CEACAM1
	Novus Biologicals CEACAM1 Antibodies
	Abcam antibodies for CEACAM1
	Uscn Antibodies for CEACAM1
	ThermoFisher Antibodies for CEACAM1

Assay Products for CEACAM1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for CEACAM1 (CEACAM-1/CD66a) (see all)
	GenScript Custom Assay Services for CEACAM1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CEACAM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CEACAM1 for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR003598 Ig_sub2

IPR013783 Ig-like_fold

IPR013106 Ig_V-set

IPR007110 Ig-like_dom

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry P13688

ProtoNet protein and cluster: P13688

2 Blocks protein families:

IPB003598 Immunoglobulin C-2 type

IPB013106 Immunoglobulin V-set

UniProtKB/Swiss-Prot: CEAM1_HUMAN, P13688

Similarity: Belongs to the immunoglobulin superfamily. CEA family

Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domains

Similarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for CEACAM1:

carcinoembryonic antigen-related cell adhesion molecule 1,biliary glycoprotein (see CEA@)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CEACAM1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEACAM1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CEACAM1 (see all 18):
		hsa-miR-485-5p hsa-miR-30c hsa-miR-323b-3p hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-340 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: CEACAM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CEACAM1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM1 (see all 14) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM1 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 6): CEACAM1 (NM_001712)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CEACAM1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CEACAM1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CEACAM1
		Search LifeMap BioReagents cell lines for CEACAM1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	--

CEACAM1 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for CEACAM1:

Synthetic lethal with imatinib

Animal Models:
Mouse knock-outs for CEACAM1: Ceacam1^tm1Bcn Ceacam1^tm2Bcn
7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Ceacam1):

cellular	digestive/alimentary	hematopoietic system	homeostasis/metabolism	immune system
mortality/aging	tumorigenesis

CEACAM1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Adhesion

Adhesion

1.00

EGFR1 Signaling Pathway

EGFR1 Signaling Pathway

1.00

Lymphocyte Signaling

Lymphocyte Signaling

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

2 Cell Signaling Technology (CST) Pathways for CEACAM1

	Lymphocyte Signaling
	Adhesion

1 BioSystems Pathway for CEACAM1

EGFR1 Signaling Pathway

CEACAM1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CEACAM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/22 Interacting proteins for CEACAM1 (P13688^{1, 2, 3} ENSP00000161559⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 22)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLEC4M	Q9H2X3²^,³, ENSP00000316228⁴	MINT-72826 MINT-72821 I2D: score=1 STRING: ENSP00000316228
SHC1	P29353²^,³, ENSP00000401303⁴	MINT-8031984 I2D: score=4 STRING: ENSP00000401303
CEACAM6	P40199¹^,³, ENSP00000199764⁴	EBI-4314481,EBI-4314501 I2D: score=1 STRING: ENSP00000199764
PTPN11	Q06124³, ENSP00000340944⁴	I2D: score=5 STRING: ENSP00000340944
ANXA2	P07355³, ENSP00000346032⁴	I2D: score=3 STRING: ENSP00000346032

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001525	angiogenesis	NAS	15687237
GO:0007156	homophilic cell adhesion	NAS	15687237
GO:0007229	integrin-mediated signaling pathway	NAS	15687237
GO:0016477	cell migration	NAS	15687237

CEACAM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CEACAM1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CEACAM1

2 DrugBank Compounds for CEACAM1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Arcitumomab	anti-Carcinoembryonic Antigen Monoclonal Antibody Fab' Fragment (see all 2)	154361-48-5	target	other/unknown	9389396 12865871
Alpha-D-Mannose	--	3458-28-4	target	--	10592235

10/19 Novoseek chemical compound relationships for CEACAM1 gene (see all 19) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
matrigel	45.4	14	19285068 (3), 10564638 (3), 15339048 (2), 14522961 (1) (see all 6)
glycogen	27.1	11	12378338 (1), 10638593 (1), 11384100 (1), 9583890 (1) (see all 7)
sialic acid	27	1	11322763 (1)
phosphatidylinositol	19.1	8	17071610 (3), 12571236 (2)
tyrosine	18.3	15	15004154 (2), 17761831 (2), 9867848 (1), 18453603 (1) (see all 9)
polysaccharide	11.9	4	20034698 (2), 16282604 (1)
vegf	11	15	11082271 (3), 15536067 (2), 17310502 (2), 19285068 (2) (see all 6)
retinoic acid	10.6	7	15364113 (4), 18552205 (2), 8609714 (1)
glucose	2.39	1	17393985 (1)
imatinib	0.461	1	14712293 (1)

Search CenterWatch for drugs/clinical trials and news about CEACAM1 / CEAM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CEACAM1 gene (6 alternative transcripts):

NM_001024912.2 NM_001184813.1 NM_001184815.1 NM_001184816.1 NM_001205344.1 NM_001712.4

Unigene Cluster for CEACAM1:

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)

Hs.512682 [show with all ESTs]

Unigene Representative Sequence: NM_001712

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000161559(uc002otv.3 uc010eij.3 uc002otw.3 uc002oty.3 uc002otz.3 uc010eik.3)

ENST00000403444 ENST00000403461 ENST00000488639 ENST00000465051 ENST00000485605

ENST00000377806(uc002oua.3 uc002oub.3) ENST00000344391 ENST00000403136(uc002ouc.3)

ENST00000471298 ENST00000358394(uc010eii.3 uc002otx.3) ENST00000351134

ENST00000352591 ENST00000308072

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CEACAM1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CEACAM1
		8/18 QIAGEN miScript miRNA Assays for microRNAs that regulate CEACAM1 (see all 18):
		hsa-miR-485-5p hsa-miR-30c hsa-miR-323b-3p hsa-miR-29c hsa-miR-29a hsa-miR-30d hsa-miR-340 hsa-miR-30a

		SwitchGear 3'UTR luciferase reporter plasmid: CEACAM1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CEACAM1 (see all 7) OriGene shRNA RFP: CEACAM1 OriGene siRNA: CEACAM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CEACAM1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM1 (see all 14) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CEACAM1 (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM1

Additional cDNA sequence:

AK314211.1 AL833584.1 AY766113.1 BC014473.1 BC024164.1 D12502.1 D90311.1 D90312.1

D90313.1 J03858.1 M69176.1 M72238.1 M76742.1 M76743.1 M76744.1 S71326.1

S74647.1 X14831.1 X16354.1 X16356.1

21 DOTS entries:

DT.95146984 DT.100658676 DT.92439258 DT.91978573 DT.121424607 DT.91781689 DT.92439264 DT.100822614

DT.121424012 DT.65286356 DT.95293755 DT.100822610 DT.86848472 DT.92420006 DT.121424282 DT.121424528

DT.40114371 DT.100712890 DT.75132501 DT.91714653 DT.95147024

24/202 AceView cDNA sequences (see all 202):

AW951862 AA700605 BM021280 BM471072 BU195866 CD612616 AW852192 D12097

M76742 AA742344 BM973416 AW611749 BC014473 BQ222884 BQ426095 BI031917

CR608576 AW027805 AI308767 AA337247 BF000355 AI346459 AW450228 BX396085

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CEACAM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

CEACAM1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Blood

Extravillous Cytotrophoblast Layer

Extravillous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Placenta

Chorionic Villus

Syncytiotrophoblast Multinuclear Cells

Extraembryonic Tissues, Placenta

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 5 LifeMap Cells

Name

Category

PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)

Blood, Endothelium

PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)

Endothelium

PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)

Endothelium

See CEACAM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CEACAM1

SOURCE GeneReport for Unigene cluster: Hs.512682

SABiosciences Expression via Pathway-Focused PCR Array including CEACAM1:

Diabetes in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CEACAM1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat CEACAM1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CEACAM1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CEACAM1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CEACAM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CEACAM1 gene from 2/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	20(a)	possible ortholog	GL344292.1(1263-21096)
zebrafish (Danio rerio)	Actinopterygii	si:ch211-264f5.6⁶ ceacam1⁶ (see all 9)	si:ch211-264f5.6 carcinoembryonic antigen-related cell adhesion mol... (see all 9)	9(a) 7(a) (see all 9)	possible ortholog possible ortholog (see all 9)	19(6354742-6392621) 16(13474237-13510603)

ENSEMBL Gene Tree for CEACAM1 (if available)
TreeFam Gene Tree for CEACAM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CEACAM1 gene

PSG9² PSG8² CEACAM4² CEACAM5² PSG11² CEACAM7² PSG3² CEACAM21²

PSG1² PSG5² PSG6² CEACAM8² PSG2² CEACAM6² CEACAM18² CEACAM16²

PSG4² CEACAM3²

18/26 SIMAP similar genes for CEACAM1 using alignment to 5 protein entries: CEAM1_HUMAN (see all proteins) (see all similar genes):

CEACAM6 CEACAM3 CEACAM7 CEACAM8 OK/SW-cl.41 CEA

CEACAM5 DHFRP2 PSG11 PSGII PSG PSG5

PSG2 CEACAM4 PSG1 CEACAM21 PSG8 SP1

CEACAM1 for paralogs About GeneDecksing

5 Pseudogenes.org Pseudogenes for CEACAM1
PGOHUM00000234325 PGOHUM00000234329 PGOHUM00000234351 PGOHUM00000250581 PGOHUM00000250610

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs41405550^1,2	C,F,	--	39441635(-)	`TTTCTC/TTACAG`	7	--	ds500¹ int¹		2		NS	90
rs11670242^1,2	H	--	39441890(+)	`TAGGCC/GTAACA`	7	--	ut3¹ int¹ ese³		4		NS EA	418
rs11541309^1,2	C	--	39441924(+)	`ATAAAA/CCCTTT`	7	--	ut3¹ int¹		1		NA	2
rs76779598^1,2		--	39442102(+)	`TCCTCC/GTCACA`	7	--	ut3¹ int¹		1		WA	118
rs1047943^1,2	C	--	39442981(-)	`AAACAC/GAAGAA`	7	--	ut3¹ int¹ ese³		7		MN NA	412
rs1047942^1,2	C	--	39442983(-)	`CCAAAC/GACAAG`	7	--	ut3¹ int¹ ese³		7		MN NA	412
rs1047941^1,2	C	--	39442988(-)	`ACTCAC/GCAAAC`	7	--	ut3¹ int¹ ese³		7		MN NA	412
rs77011148^1,2	F,	--	39443079(+)	`AATGGA/GAAAGG`	7	--	ut3¹ int¹		1		EA	120
rs41448247^1,2	C,	--	39443391(-)	`AGAGGG/AGTGGG`	7	--	int¹ ut3¹		2		NS	94
rs201444822^1,2	C	--	39443523(-)	`CCCTAA/CCAGCC`	10	T P	mis¹ ut3¹ int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CEACAM1 (43011458 - 43032661 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CEACAM1
2 CNVs: 5445 5446

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CEACAM1 for disorders           About GeneDecksing

OMIM gene information: 109770    OMIM disorders: --

20/53 diseases for CEACAM1 (see all 53):    About MalaCards

non-small cell lung carcinoma lichen planus oral lichen planus primary biliary cirrhosis

squamous cell carcinoma urinary bladder cancer cutaneous malignant melanoma oral squamous cell carcinoma

adenomatoid tumor obstructive jaundice esophageal squamous cell carcinoma pancreatic endocrine tumors

carcinoma jaundice gonorrhea cushing's syndrome

endometrial carcinoma gastric cancer endometrial cancer liver disease

1 disease from the University of Copenhagen DISEASES database for CEACAM1:

Gonorrhea

10/48 Novoseek disease relationships for CEACAM1 gene (see all 48) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
endometrial neoplasia	53.8	1	16633066 (1)
colon carcinoma	47.3	2	1815506 (1), 9028835 (1)
carcinoma	46.4	74	12469186 (7), 19442569 (4), 11480789 (4), 19243897 (4) (see all 22)
colon tumor	44.6	4	18927117 (1), 11278391 (1), 18507857 (1), 8402684 (1)
tumors	43.2	126	17057731 (8), 12122002 (5), 15568039 (5), 15952183 (5) (see all 55)
gastrointestinal carcinoma	41.6	1	8188529 (1)
colorectal carcinoma	40.5	13	10638593 (5), 10374690 (2), 7504281 (1), 17057731 (1) (see all 6)
adenoma	34.2	12	10638593 (2), 10374690 (2), 15476270 (2), 9858884 (1) (see all 7)
colon cancer	33.9	11	9858884 (2), 15568039 (2), 9028835 (1), 18278069 (1) (see all 6)
gastric carcinoma	31.5	7	10374690 (2), 11480789 (2), 19243897 (2), 10638593 (1)

Genetic Association Database (GAD): CEACAM1
Human Genome Epidemiology (HuGE) Navigator: CEACAM1 (3 documents)

Export disorders for CEACAM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CEACAM1 gene, integrated from 9 sources (see all 283):
(articles sorted by number of sources associating them with CEACAM1)

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Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library. (PubMed id 2025273)^{1, 2, 3} Kuroki M.... Matsuoka Y. (1991)
Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. (PubMed id 2457922)^{1, 2, 3} Hinoda Y.... Paxton R.J. (1988)
Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene. (PubMed id 7628460)^{1, 2, 9} Nedellec P.... Beauchemin N. (1995)
Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. (PubMed id 8055923)^{1, 2, 9} Hauck W....Beauchemin N. (1994)
Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae. (PubMed id 16929097)^{1, 2, 9} Fedarovich A....Davies C. (2006)
Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins. (PubMed id 8423792)^{1, 2, 9} Barnett T.R.... Pickle W. II (1993)
Bone mineral density and five prominent candidate genes in Chinese men: associations, interaction effects and their implications. (PubMed id 15917161)^{1, 4} Lei S.F....Deng H.W. (2005)
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)^{1, 2} Liu T.... Smith R.D. (2005)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)^{1, 2} Grimwood J.... Lucas S.M. (2004)
Redefined nomenclature for members of the carcinoembryonic antigen family. (PubMed id 11501563)^{1, 2} Beauchemin N....Zimmermann W. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 634	HGNC: 1814	AceView: CEACAM1	Ensembl:ENSG00000079385	euGenes: HUgn634
ECgene: CEACAM1	H-InvDB: CEACAM1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CEACAM1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CEACAM1	Genetics and Cytogenetics in Oncology and Haematology
SeattleSNPs	http://pga.gs.washington.edu/data/ceacam1/

Intellectual Property for CEACAM1 gene
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Patent Information for CEACAM1 gene:
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GeneCards and IP:
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carcinoembryonic antigen-related cell adhesion molecule...

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carcinoembryonic antigen-related cell adhesion molecule...

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