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Aliases for CEACAM1 Gene

Aliases for CEACAM1 Gene

  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein) 2 3
  • BGP 3 4 6
  • CD66a Antigen 3 4
  • BGP1 3 4
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 3
  • Biliary Glycoprotein 1 4
  • Antigen CD66 3
  • BGP-1 4
  • BGPI 3

External Ids for CEACAM1 Gene

Previous Symbols for CEACAM1 Gene

  • BGP

Summaries for CEACAM1 Gene

Entrez Gene Summary for CEACAM1 Gene

  • This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

GeneCards Summary for CEACAM1 Gene

CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein)) is a Protein Coding gene. Diseases associated with CEACAM1 include gonorrhea and adenomatoid tumor. Among its related pathways are Adhesion and EGFR1 Signaling Pathway. An important paralog of this gene is CEACAM8.

Gene Wiki entry for CEACAM1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM1 Gene

Genomics for CEACAM1 Gene

Genomic Location for CEACAM1 Gene

Start:
42,507,304 bp from pter
End:
42,561,234 bp from pter
Size:
53,931 bases
Orientation:
Minus strand

Genomic View for CEACAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CEACAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM1 Gene

Regulatory Elements for CEACAM1 Gene

Proteins for CEACAM1 Gene

  • Protein details for CEACAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13688-CEAM1_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 1
    Protein Accession:
    P13688
    Secondary Accessions:
    • A6NE38
    • A8MY49
    • O60430
    • Q069I7
    • Q13854
    • Q13857
    • Q13858
    • Q13859
    • Q13860
    • Q15600
    • Q15601
    • Q16170
    • Q5UB49
    • Q7KYP5
    • Q96CA7
    • Q9UQV9

    Protein attributes for CEACAM1 Gene

    Size:
    526 amino acids
    Molecular mass:
    57560 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA57141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEACAM1 Gene

    Alternative splice isoforms for CEACAM1 Gene

neXtProt entry for CEACAM1 Gene

Proteomics data for CEACAM1 Gene at MOPED

Post-translational modifications for CEACAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn104, Asn111, Asn115, Asn152, Asn182, Asn197, Asn208, Asn224, Asn232, Asn254, Asn274, Asn288, Asn292, Asn302, Asn309, Asn345, Asn351, Asn363, Asn378, and Asn405

No data available for DME Specific Peptides for CEACAM1 Gene

Domains for CEACAM1 Gene

Gene Families for CEACAM1 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

UniProtKB/Swiss-Prot:

CEAM1_HUMAN
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • P13688
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P13688
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.:
    • P13688
genes like me logo Genes that share domains with CEACAM1: view

Function for CEACAM1 Gene

Molecular function for CEACAM1 Gene

GENATLAS Biochemistry: carcinoembryonic antigen-related cell adhesion molecule 1,biliary glycoprotein (see CEA@)

Gene Ontology (GO) - Molecular Function for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 18497748
GO:0042803 protein homodimerization activity IMP 19948502
genes like me logo Genes that share ontologies with CEACAM1: view
genes like me logo Genes that share phenotypes with CEACAM1: view

Animal Models for CEACAM1 Gene

MGI Knock Outs for CEACAM1:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for CEACAM1 Gene

Localization for CEACAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Cell membrane; Single-pass type I membrane protein.
Isoform 6: Cell membrane; Single-pass type I membrane protein.
Isoform 7: Cell membrane; Single-pass type I membrane protein.
Isoform 8: Cell membrane; Single-pass type I membrane protein. Note=Localizes to sites of cell-cell contact.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CEACAM1 Gene COMPARTMENTS Subcellular localization image for CEACAM1 gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytoskeleton 1
endosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 15687237
GO:0016020 membrane TAS 2457922
GO:0016021 integral component of membrane IDA 11994468
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CEACAM1: view

Pathways for CEACAM1 Gene

genes like me logo Genes that share pathways with CEACAM1: view

Pathways by source for CEACAM1 Gene

2 Cell Signaling Technology pathways for CEACAM1 Gene
1 BioSystems pathway for CEACAM1 Gene

Gene Ontology (GO) - Biological Process for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 15687237
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules NAS 15687237
GO:0007229 integrin-mediated signaling pathway NAS 15687237
GO:0007596 blood coagulation TAS --
GO:0016477 cell migration NAS 15687237
genes like me logo Genes that share ontologies with CEACAM1: view

Compounds for CEACAM1 Gene

(2) Drugbank Compounds for CEACAM1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target
Arcitumomab
  • anti-Carcinoembryonic Antigen Monoclonal Antibody Fab' Fragment
154361-48-5 target other/unknown

(19) Novoseek inferred chemical compound relationships for CEACAM1 Gene

Compound -log(P) Hits PubMed IDs
matrigel 45.4 11
glycogen 27.1 7
sialic acid 27 1
phosphatidylinositol 19.1 5
tyrosine 18.3 11
genes like me logo Genes that share compounds with CEACAM1: view

Transcripts for CEACAM1 Gene

Unigene Clusters for CEACAM1 Gene

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM1 Gene

No ASD Table

Relevant External Links for CEACAM1 Gene

GeneLoc Exon Structure for
CEACAM1
ECgene alternative splicing isoforms for
CEACAM1

Expression for CEACAM1 Gene

mRNA expression in normal human tissues for CEACAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM1 Gene

This gene is overexpressed in Colon - Transverse (13.7), Whole Blood (7.2), Esophagus - Mucosa (5.6), and Minor Salivary Gland (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CEACAM1 Gene

SOURCE GeneReport for Unigene cluster for CEACAM1 Gene Hs.512682

genes like me logo Genes that share expressions with CEACAM1: view

Orthologs for CEACAM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM1 36
  • 98.77 (n)
  • 97.6 (a)
CEACAM1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 34 (a)
ManyToMany
CEACAM1 37
  • 58 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia CEACAM8 36
  • 77.22 (n)
  • 63.64 (a)
mouse
(Mus musculus)
Mammalia Ceacam1 36
  • 72.19 (n)
  • 58 (a)
Ceacam1 16
Psg25 37
  • 27 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 29 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Ceacam1 36
  • 70.65 (n)
  • 55.88 (a)
Species with no ortholog for CEACAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM1 Gene

ENSEMBL:
Gene Tree for CEACAM1 (if available)
TreeFam:
Gene Tree for CEACAM1 (if available)

Paralogs for CEACAM1 Gene

genes like me logo Genes that share paralogs with CEACAM1: view

Variants for CEACAM1 Gene

Sequence variations from dbSNP and Humsavar for CEACAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
VAR_049844 -
VAR_049845 -
VAR_049846 -
VAR_049847 -

Structural Variations from Database of Genomic Variants (DGV) for CEACAM1 Gene

Variant ID Type Subtype PubMed ID
nsv526186 CNV Gain 19592680
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639

Relevant External Links for CEACAM1 Gene

HapMap Linkage Disequilibrium report
CEACAM1

Disorders for CEACAM1 Gene

(2) MalaCards Diseases for CEACAM1 Gene

Search for CEACAM1 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CEACAM1 Gene

(48) Novoseek inferred disease relationships for CEACAM1 Gene

Disease -log(P) Hits PubMed IDs
endometrial neoplasia 53.8 1
colon carcinoma 47.3 2
carcinoma 46.4 47
colon tumor 44.6 4
tumors 43.2 88

Relevant External Links for CEACAM1

Genetic Association Database (GAD)
CEACAM1
Human Genome Epidemiology (HuGE) Navigator
CEACAM1
genes like me logo Genes that share disorders with CEACAM1: view

No data available for UniProtKB/Swiss-Prot for CEACAM1 Gene

Publications for CEACAM1 Gene

  1. Human biliary glycoprotein gene: characterization of a family of novel alternatively spliced RNAs and their expressed proteins. (PMID: 8423792) Barnett T.R. … Pickle W. II (Mol. Cell. Biol. 1993) 3 4 23
  2. Characterization and transcriptional activity of the mouse biliary glycoprotein 1 gene, a carcinoembryonic antigen-related gene. (PMID: 7628460) Nedellec P. … Beauchemin N. (Eur. J. Biochem. 1995) 3 4 23
  3. Transcriptional control of the human biliary glycoprotein gene, a CEA gene family member down-regulated in colorectal carcinomas. (PMID: 8055923) Hauck W. … Beauchemin N. (Eur. J. Biochem. 1994) 3 4 23
  4. Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae. (PMID: 16929097) Fedarovich A. … Davies C. (Acta Crystallogr. D 2006) 3 4 23
  5. Three novel molecular forms of biliary glycoprotein deduced from cDNA clones from a human leukocyte library. (PMID: 2025273) Kuroki M. … Matsuoka Y. (Biochem. Biophys. Res. Commun. 1991) 2 3 4

Products for CEACAM1 Gene

  • antibodies-online proteins for CEACAM1
  • antibodies-online antibodies for CEACAM1
  • antibodies-online kits for CEACAM1

Sources for CEACAM1 Gene

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