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Aliases for CEACAM1 Gene

Aliases for CEACAM1 Gene

  • Carcinoembryonic Antigen Related Cell Adhesion Molecule 1 2 3 5
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 (Biliary Glycoprotein) 2 3
  • CD66a Antigen 3 4
  • BGP1 3 4
  • BGP 3 4
  • Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1 3
  • Biliary Glycoprotein 1 4
  • Antigen CD66 3
  • BGP-1 4
  • BGPI 3

External Ids for CEACAM1 Gene

Previous HGNC Symbols for CEACAM1 Gene

  • BGP

Previous GeneCards Identifiers for CEACAM1 Gene

  • GC19M043658
  • GC19M043403
  • GC19M047687
  • GC19M047703
  • GC19M043009
  • GC19M039441

Summaries for CEACAM1 Gene

Entrez Gene Summary for CEACAM1 Gene

  • This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of all variants has not been defined. [provided by RefSeq, May 2010]

GeneCards Summary for CEACAM1 Gene

CEACAM1 (Carcinoembryonic Antigen Related Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CEACAM1 include Colorectal Cancer and Microinvasive Gastric Cancer. Among its related pathways are Adhesion and Innate Immune System. GO annotations related to this gene include protein homodimerization activity. An important paralog of this gene is CEACAM5.

UniProtKB/Swiss-Prot for CEACAM1 Gene

  • Isoform 1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity).

  • Isoform 8: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity).

Gene Wiki entry for CEACAM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CEACAM1 Gene

Genomics for CEACAM1 Gene

Regulatory Elements for CEACAM1 Gene

Enhancers for CEACAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G042472 1 ENCODE dbSUPER 4.6 +86.2 86171 4.6 ZNF792 ZSCAN4 TEAD4 CEBPG CHD7 ZSCAN5C SCRT2 ZNF263 CEBPB ZFP37 CXCL17 CEACAM1 RNU4-60P GC19M042479
GH19G042449 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.2 +110.9 110905 1.7 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 YY1 SLC30A9 ZNF143 ZNF207 LIPE RNU4-60P PSG8 CD177 CEACAM1 CXCL17 PIR51613
GH19G042760 1.5 FANTOM5 Ensembl ENCODE 1.4 -200.6 -200634 3.4 PKNOX1 ZSCAN4 INSM2 FEZF1 ZNF2 ZEB1 ZNF335 GLIS2 ZNF366 FOS PSG8 PSG5 CEACAM1 GC19M042749 PSG3
GH19G042526 1.2 Ensembl ENCODE 0.3 +33.0 33025 3.6 HDGF MLX WRNIP1 ARID4B ZNF48 YY1 ZNF143 SP5 REST PPARG CXCL17 ENSG00000268355 LOC105372407 CEACAM1
GH19G042553 0.6 Ensembl 0.4 +7.6 7634 1.2 GATAD2A NR2F1 ZNF384 ZBTB7B RARA CEBPA NR2F6 BCL6 RXRB CXCL17 CEACAM1 LOC105372407
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CEACAM1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CEACAM1 Gene

Chromosome:
19
Start:
42,507,304 bp from pter
End:
42,561,234 bp from pter
Size:
53,931 bases
Orientation:
Minus strand

Genomic View for CEACAM1 Gene

Genes around CEACAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CEACAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CEACAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CEACAM1 Gene

Proteins for CEACAM1 Gene

  • Protein details for CEACAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P13688-CEAM1_HUMAN
    Recommended name:
    Carcinoembryonic antigen-related cell adhesion molecule 1
    Protein Accession:
    P13688
    Secondary Accessions:
    • A6NE38
    • A8MY49
    • O60430
    • Q069I7
    • Q13854
    • Q13857
    • Q13858
    • Q13859
    • Q13860
    • Q15600
    • Q15601
    • Q16170
    • Q5UB49
    • Q7KYP5
    • Q96CA7
    • Q9UQV9

    Protein attributes for CEACAM1 Gene

    Size:
    526 amino acids
    Molecular mass:
    57560 Da
    Quaternary structure:
    • Monomer. Oligomer. Heterodimer. Homodimer. Cis-dimer/oligomer (via Ig-like C2-type and/or via cytoplasmic domains); induced by trans-homophilic cell adhesion through an allosteric mechanism transmitted by the Ig-like V-type domain, and is regulated by intracellular calcium and calmodulin. Interacts (via cytoplasmic domain) with calmodulin in a calcium dependent manner; reduces homophilic cell adhesion through dissociation of dimer (By similarity). Isoform 1 interacts (via cytoplasmic domain) with PTPN11 (preferentially) and PTPN6; cis-homodimer form is preferred; this interaction is decreased by formation of Isoform 1 /Isoform 8 cis-heterodimers and is dependent on the monomer/dimer equilibrium; this interaction is phosphorylation-dependent (PubMed:23696226). Isoform 1 interacts with LYN (By similarity). Isoform 1 interacts (via cytoplasmic domain) with SRC (via SH2 domain); this interaction is regulated by trans-homophilic cell adhesion (PubMed:7478590). Isoform 1 interacts (via cytoplasmic domain) with LCK; mediates phosphorylation at Tyr-493 and Tyr-520 resulting in PTPN6 association. Isoform 1 interacts with PTPN6; this interaction is phosphorylation-dependent and causes a profound decrease in TCR stimulation-induced CD247 and ZAP70 phosphorylation. Isoform 1 interacts with TCR/CD3 complex through TCR beta chain and CD3E; colocalizes at the cell surface and upon stimulation of the TCR/CD3 complex recuits PTPN6 in the TCR/CD3 complex, resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Isoform 1 interacts (via cytoplasmic domain) with SHC1 (via SH2 domain); SHC1 mediates interaction with INSR or EGFR in a Ser-508 phosphorylation-dependent manner (By similarity). Isoform 1 interacts with EGFR; the interaction is indirect (PubMed:15467833). Isoform 1 interacts with CSF3R; down-regulates the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Isoform 1 (phosphorylated form) interacts with TLR4 and SYK; recruits PTPN6 that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, leading to a reduction of the inflammasome activity (By similarity). Isoform 1 interacts with FLNA; inhibits cell migration and cell scattering by interfering with the interaction of FLNA with RALA (PubMed:16291724). Isoform 1 interacts (via cytoplasmic domain) with PXN; the interaction is phosphotyrosyl-dependent (PubMed:11035932). Isoform 1 interacts with KLRK1; recruits PTPN6 that dephosphorylates VAV1 (PubMed:23696226). Isoform 1 interacts with CEACAM8 (PubMed:11994468). Isoform 1 interacts with FASN; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity (By similarity). Interacts (via Ig-like V-type) with HAVCR2 (via Ig-like V-type); facilitates the maturation and cell surface expression of HAVCR2 thereby regulating T cell tolerance induction (PubMed:25363763). Isoform 8 interacts (via the cytoplasmic domain) with ANXA2; this interaction is regulated by phosphorylation and appears in the AIIt complex (PubMed:14522961). Interacts (via Lewis X moieties) with CD209 (via C-type lectin domain); this interaction is regulated by the glycosylation pattern of CEACAM1 on cell types and regulates contact between dendritic cells and neutrophils (PubMed:16246332).
    SequenceCaution:
    • Sequence=AAA57141.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CEACAM1 Gene

    Alternative splice isoforms for CEACAM1 Gene

neXtProt entry for CEACAM1 Gene

Post-translational modifications for CEACAM1 Gene

  • Isoform 1: Phosphorylated on serine and tyrosine (By similarity). Isoform 1 is phosphorylated on tyrosine by Src family kinases like SRC and LCK and by receptor like CSF3R, EGFR and INSR upon stimulation (PubMed:15467833, PubMed:18424730, PubMed:7478590). Phosphorylated at Ser-508; mediates activity. Phosphorylated at Tyr-493; regulates activity (By similarity). Phosphorylated at Tyr-493 by EGFR and INSR upon stimulation; this phosphorylation is Ser-508-phosphorylation-dependent; mediates cellular internalization; increases interaction with downstream proteins like SHC1 and FASN (By similarity). Phosphorylated at Tyr-493 and Tyr-520 by LCK; mediates PTPN6 association and is regulated by homophilic ligation of CEACAM1 in the absence of T cell activation (PubMed:18424730). Phosphorylated at Tyr-520; mediates interaction with PTPN11 (By similarity).
  • Isoform 8: Phosphorylated on serine and threonine.
  • Glycosylation at posLast=104104, Asn111, posLast=115115, posLast=152152, Asn182, Asn197, Asn208, posLast=224224, Asn232, Asn254, Asn274, posLast=288288, posLast=292292, posLast=302302, Asn309, Asn345, Asn351, posLast=363363, posLast=378378, and Asn405
  • Modification sites at PhosphoSitePlus

Antibody Products

  • R&D Systems Antibodies for CEACAM1 (CEACAM-1/CD66a)
  • Cell Signaling Technology (CST) Antibodies for CEACAM1 (CEACAM1)

No data available for DME Specific Peptides for CEACAM1 Gene

Domains & Families for CEACAM1 Gene

Suggested Antigen Peptide Sequences for CEACAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P13688

UniProtKB/Swiss-Prot:

CEAM1_HUMAN :
  • Ig-like V-type domain mediates trans-homophilic cell adhesion through homodimerization and this active process is regulated by tyrosine kinase, PTPN11 AND PTPN6. Ig-like C2-type and/or cytoplasmic domains mediate cis-dimer/oligomer.
  • Belongs to the immunoglobulin superfamily. CEA family.
Domain:
  • Ig-like V-type domain mediates trans-homophilic cell adhesion through homodimerization and this active process is regulated by tyrosine kinase, PTPN11 AND PTPN6. Ig-like C2-type and/or cytoplasmic domains mediate cis-dimer/oligomer.
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with CEACAM1: view

Function for CEACAM1 Gene

Molecular function for CEACAM1 Gene

GENATLAS Biochemistry:
carcinoembryonic antigen-related cell adhesion molecule 1,biliary glycoprotein (see CEA@)
UniProtKB/Swiss-Prot Function:
Isoform 1: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Plays a role as coinhibitory receptor in immune response, insulin action and functions also as an activator during angiogenesis (PubMed:18424730, PubMed:23696226, PubMed:25363763). Its coinhibitory receptor function is phosphorylation- and PTPN6 -dependent, which in turn, suppress signal transduction of associated receptors by dephosphorylation of their downstream effectors. Plays a role in immune response, of T cells, natural killer (NK) and neutrophils (PubMed:18424730, PubMed:23696226). Upon TCR/CD3 complex stimulation, inhibits TCR-mediated cytotoxicity by blocking granule exocytosis by mediating homophilic binding to adjacent cells, allowing interaction with and phosphorylation by LCK and interaction with the TCR/CD3 complex which recruits PTPN6 resulting in dephosphorylation of CD247 and ZAP70 (PubMed:18424730). Also inhibits T cell proliferation and cytokine production through inhibition of JNK cascade and plays a crucial role in regulating autoimmunity and anti-tumor immunity by inhibiting T cell through its interaction with HAVCR2 (PubMed:25363763). Upon natural killer (NK) cells activation, inhibit KLRK1-mediated cytolysis of CEACAM1-bearing tumor cells by trans-homophilic interactions with CEACAM1 on the target cell and lead to cis-interaction between CEACAM1 and KLRK1, allowing PTPN6 recruitment and then VAV1 dephosphorylation (PubMed:23696226). Upon neutrophils activation negatively regulates IL1B production by recruiting PTPN6 to a SYK-TLR4-CEACAM1 complex, that dephosphorylates SYK, reducing the production of reactive oxygen species (ROS) and lysosome disruption, which in turn, reduces the activity of the inflammasome. Downregulates neutrophil production by acting as a coinhibitory receptor for CSF3R by downregulating the CSF3R-STAT3 pathway through recruitment of PTPN6 that dephosphorylates CSF3R (By similarity). Also regulates insulin action by promoting INS clearance and regulating lipogenesis in liver through regulating insulin signaling (By similarity). Upon INS stimulation, undergoes phosphorylation by INSR leading to INS clearance by increasing receptor-mediated insulin endocytosis. This inernalization promotes interaction with FASN leading to receptor-mediated insulin degradation and to reduction of FASN activity leading to negative regulation of fatty acid synthesis. INSR-mediated phosphorylation also provokes a down-regulation of cell proliferation through SHC1 interaction resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 and phosphatidylinositol 3-kinase pathways (By similarity). Functions as activator in angiogenesis by promoting blood vessel remodeling through endothelial cell differentiation and migration and in arteriogenesis by increasing the number of collateral arteries and collateral vessel calibers after ischemia. Also regulates vascular permeability through the VEGFR2 signaling pathway resulting in control of nitric oxide production (By similarity). Downregulates cell growth in response to EGF through its interaction with SHC1 that mediates interaction with EGFR resulting in decrease coupling of SHC1 to the MAPK3/ERK1-MAPK1/ERK2 pathway (By similarity). Negatively regulates platelet aggregation by decreasing platelet adhesion on type I collagen through the GPVI-FcRgamma complex (By similarity). Inhibits cell migration and cell scattering through interaction with FLNA; interfers with the interaction of FLNA with RALA (PubMed:16291724). Mediates bile acid transport activity in a phosphorylation dependent manner (By similarity). Negatively regulates osteoclastogenesis (By similarity).
UniProtKB/Swiss-Prot Function:
Isoform 8: Cell adhesion protein that mediates homophilic cell adhesion in a calcium-independent manner (By similarity). Promotes populations of T cells regulating IgA production and secretion associated with control of the commensal microbiota and resistance to enteropathogens (By similarity).
UniProtKB/Swiss-Prot Induction:
Induced in primary T cells by activation with IL-2.

Gene Ontology (GO) - Molecular Function for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003779 actin binding IPI 17192268
GO:0005515 protein binding IPI 11035932
GO:0015125 bile acid transmembrane transporter activity ISS --
GO:0019900 kinase binding IPI 7478590
genes like me logo Genes that share ontologies with CEACAM1: view
genes like me logo Genes that share phenotypes with CEACAM1: view

Animal Models for CEACAM1 Gene

MGI Knock Outs for CEACAM1:

Animal Model Products

CRISPR Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CEACAM1 Gene

Localization for CEACAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CEACAM1 Gene

Isoform 1: Cell membrane; Single-pass type I membrane protein. Lateral cell membrane. Apical cell membrane. Basal cell membrane. Cell junction. Cell junction, adherens junction. Note=Canalicular domain of hepatocyte plasma membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions. Found as dimer in the solution. Predominantly localized to the lateral cell membranes. {ECO:0000250 UniProtKB:P16573}.
Isoform 2: Secreted.
Isoform 3: Secreted.
Isoform 4: Secreted.
Isoform 5: Cell membrane; Single-pass type I membrane protein.
Isoform 6: Cell membrane; Single-pass type I membrane protein.
Isoform 7: Cell membrane; Single-pass type I membrane protein.
Isoform 8: Cell membrane; Single-pass type I membrane protein. Cytoplasmic vesicle, secretory vesicle membrane. Lateral cell membrane. Apical cell membrane. Basal cell membrane. Cell junction. Cell junction, adherens junction. Note=Predominantly localized to the lateral cell membranes. Found as a mixture of monomer, dimer and oligomer in the plasma membrane. Occurs predominantly as cis-dimers and/or small cis-oligomers in the cell junction regions (By similarity). Co-localizes with ANXA2 in secretory vesicles and with S100A10/p11 at the plasma membrane (PubMed:14522961). {ECO:0000250 UniProtKB:P16573, ECO:0000269 PubMed:14522961}.
Cell projection, microvillus membrane; Single-pass type I membrane protein. Apical cell membrane; Single-pass type I membrane protein. Note=Colocalizes with CEACAM20 at the apical brush border of intestinal cells. {ECO:0000250 UniProtKB:P31809}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CEACAM1 gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 15687237
GO:0005911 cell-cell junction IDA 16291724
GO:0005912 adherens junction ISS --
genes like me logo Genes that share ontologies with CEACAM1: view

Pathways & Interactions for CEACAM1 Gene

genes like me logo Genes that share pathways with CEACAM1: view

Pathways by source for CEACAM1 Gene

SIGNOR curated interactions for CEACAM1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CEACAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis NAS 15687237
GO:0001558 regulation of cell growth ISS --
GO:0001568 blood vessel development ISS --
GO:0001915 negative regulation of T cell mediated cytotoxicity IDA 18424730
GO:0002859 negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target IMP 23696226
genes like me logo Genes that share ontologies with CEACAM1: view

Drugs & Compounds for CEACAM1 Gene

(10) Drugs for CEACAM1 Gene - From: DrugBank, DGIdb, FDA Approved Drugs, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Arcitumomab Approved, Investigational Pharma antibody, Target, other/unknown 0
CEA-Scan Approved April 1996 Pharma 0

(11) Additional Compounds for CEACAM1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CEACAM1: view

Transcripts for CEACAM1 Gene

Unigene Clusters for CEACAM1 Gene

Carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein):
Representative Sequences:

CRISPR Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CEACAM1 Gene

No ASD Table

Relevant External Links for CEACAM1 Gene

GeneLoc Exon Structure for
CEACAM1
ECgene alternative splicing isoforms for
CEACAM1

Expression for CEACAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CEACAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CEACAM1 Gene

This gene is overexpressed in Colon - Transverse (x13.7), Whole Blood (x7.2), Esophagus - Mucosa (x5.6), and Minor Salivary Gland (x5.0).

Protein differential expression in normal tissues from HIPED for CEACAM1 Gene

This gene is overexpressed in Neutrophil (30.8) and Nasal epithelium (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CEACAM1 Gene



NURSA nuclear receptor signaling pathways regulating expression of CEACAM1 Gene:

CEACAM1

SOURCE GeneReport for Unigene cluster for CEACAM1 Gene:

Hs.512682

mRNA Expression by UniProt/SwissProt for CEACAM1 Gene:

P13688-CEAM1_HUMAN
Tissue specificity: The predominant forms expressed by T cells are those containing a long cytoplasmic domain (PubMed:18424730). Expressed in granulocytes and lymphocytes. Leukocytes only express isoforms 6 and isoform 1 (PubMed:11994468).

Evidence on tissue expression from TISSUES for CEACAM1 Gene

  • Liver(4.6)
  • Blood(4.4)
  • Bone marrow(4.4)
  • Intestine(4.3)
  • Skin(4.1)
  • Kidney(2.6)
genes like me logo Genes that share expression patterns with CEACAM1: view

Primer Products

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CEACAM1 Gene

Orthologs for CEACAM1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for CEACAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CEACAM1 34 35
  • 98.77 (n)
dog
(Canis familiaris)
Mammalia CEACAM8 34
  • 77.22 (n)
mouse
(Mus musculus)
Mammalia Ceacam1 34
  • 72.19 (n)
Psg25 35
  • 27 (a)
ManyToMany
Ceacam2 16
rat
(Rattus norvegicus)
Mammalia Ceacam1 34
  • 70.65 (n)
cow
(Bos Taurus)
Mammalia CEACAM1 35
  • 58 (a)
ManyToMany
-- 35
  • 34 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 29 (a)
ManyToMany
Species where no ortholog for CEACAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CEACAM1 Gene

ENSEMBL:
Gene Tree for CEACAM1 (if available)
TreeFam:
Gene Tree for CEACAM1 (if available)

Paralogs for CEACAM1 Gene

Variants for CEACAM1 Gene

Sequence variations from dbSNP and Humsavar for CEACAM1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs879255372 Uncertain significance 42,528,331(-) ACCCT(A/G)GCAGG intron-variant, reference, stop-gained
rs1000071357 -- 42,516,706(+) AAAAG(-/AACAA)AGTTG intron-variant
rs1000297387 -- 42,509,632(+) GTAGA(G/T)TTTTT intron-variant
rs1000677126 -- 42,525,216(+) GATAG(A/G)CCTGA intron-variant
rs1000726265 -- 42,525,547(+) TCTGA(C/G/T)ACTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CEACAM1 Gene

Variant ID Type Subtype PubMed ID
dgv15e196 CNV deletion 17116639
esv2422471 CNV deletion 17116639
nsv526186 CNV gain 19592680
nsv963054 CNV duplication 23825009

Variation tolerance for CEACAM1 Gene

Residual Variation Intolerance Score: 64.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.05; 68.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CEACAM1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CEACAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CEACAM1 Gene

Disorders for CEACAM1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CEACAM1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
colorectal cancer
  • colorectal cancer, somatic
microinvasive gastric cancer
  • early gastric cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CEACAM1

Genetic Association Database (GAD)
CEACAM1
Human Genome Epidemiology (HuGE) Navigator
CEACAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CEACAM1
genes like me logo Genes that share disorders with CEACAM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CEACAM1 Gene

Publications for CEACAM1 Gene

  1. Carcinoembryonic antigen-related cell adhesion molecule 1 inhibits proximal TCR signaling by targeting ZAP-70. (PMID: 18424730) Chen Z. … Blumberg R.S. (J. Immunol. 2008) 3 4 22 64
  2. Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae. (PMID: 16929097) Fedarovich A. … Davies C. (Acta Crystallogr. D 2006) 3 4 22 64
  3. Interactions of DC-SIGN with Mac-1 and CEACAM1 regulate contact between dendritic cells and neutrophils. (PMID: 16246332) van Gisbergen K.P. … van Kooyk Y. (FEBS Lett. 2005) 3 4 22 64
  4. CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis. (PMID: 14522961) Kirshner J. … Shively J.E. (J. Biol. Chem. 2003) 3 4 22 64
  5. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. (PMID: 11994468) Singer B.B. … Obrink B. (J. Immunol. 2002) 3 4 22 64

Products for CEACAM1 Gene

Sources for CEACAM1 Gene

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