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Aliases for CDYL2 Gene

Aliases for CDYL2 Gene

  • Chromodomain Protein, Y-Like 2 2 3
  • Chromodomain Y-Like Protein 2 2 3
  • CDY-Like 2 3 4
  • Prostate Cancer Candidate Protein 1, PCCP1 3
  • PCCP1 3

External Ids for CDYL2 Gene

Summaries for CDYL2 Gene

GeneCards Summary for CDYL2 Gene

CDYL2 (Chromodomain Protein, Y-Like 2) is a Protein Coding gene. Diseases associated with CDYL2 include prostate cancer. GO annotations related to this gene include methylated histone binding. An important paralog of this gene is CDY1B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDYL2 Gene

Genomics for CDYL2 Gene

Genomic Location for CDYL2 Gene

Start:
80,597,906 bp from pter
End:
80,804,329 bp from pter
Size:
206,424 bases
Orientation:
Minus strand

Genomic View for CDYL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDYL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDYL2 Gene

Proteins for CDYL2 Gene

  • Protein details for CDYL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8U2-CDYL2_HUMAN
    Recommended name:
    Chromodomain Y-like protein 2
    Protein Accession:
    Q8N8U2
    Secondary Accessions:
    • Q7Z5I8

    Protein attributes for CDYL2 Gene

    Size:
    506 amino acids
    Molecular mass:
    56500 Da
    Quaternary structure:
    • Interacts (via chromo domain) with histone H3K9me3.

    Three dimensional structures from OCA and Proteopedia for CDYL2 Gene

neXtProt entry for CDYL2 Gene

Proteomics data for CDYL2 Gene at MOPED

Post-translational modifications for CDYL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDYL2 Gene

No data available for DME Specific Peptides for CDYL2 Gene

Domains for CDYL2 Gene

Suggested Antigen Peptide Sequences for CDYL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N8U2

UniProtKB/Swiss-Prot:

CDYL2_HUMAN
Domain:
  • Contains 1 chromo domain.:
    • Q8N8U2
genes like me logo Genes that share domains with CDYL2: view

No data available for Gene Families for CDYL2 Gene

Function for CDYL2 Gene

Gene Ontology (GO) - Molecular Function for CDYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0005515 protein binding IPI 17577209
GO:0035064 methylated histone binding IEA --
genes like me logo Genes that share ontologies with CDYL2: view

Phenotypes for CDYL2 Gene

GenomeRNAi human phenotypes for CDYL2:
genes like me logo Genes that share phenotypes with CDYL2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDYL2 Gene

Localization for CDYL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDYL2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDYL2 Gene COMPARTMENTS Subcellular localization image for CDYL2 gene
Compartment Confidence
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for CDYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CDYL2: view

Pathways for CDYL2 Gene

SuperPathways for CDYL2 Gene

No Data Available

Interacting Proteins for CDYL2 Gene

Selected Interacting proteins: Q8N8U2-CDYL2_HUMAN for CDYL2 Gene via UniProtKB

Symbol External ID(s) Details
PRMT5

Gene Ontology (GO) - Biological Process for CDYL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CDYL2: view

No data available for Pathways by source for CDYL2 Gene

Transcripts for CDYL2 Gene

Unigene Clusters for CDYL2 Gene

Chromodomain protein, Y-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDYL2 Gene

No ASD Table

Relevant External Links for CDYL2 Gene

GeneLoc Exon Structure for
CDYL2
ECgene alternative splicing isoforms for
CDYL2

Expression for CDYL2 Gene

mRNA expression in normal human tissues for CDYL2 Gene

mRNA differential expression in normal tissues according to GTEx for CDYL2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CDYL2 Gene

SOURCE GeneReport for Unigene cluster for CDYL2 Gene Hs.373908

mRNA Expression by UniProt/SwissProt for CDYL2 Gene

Q8N8U2-CDYL2_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with CDYL2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CDYL2 Gene

Orthologs for CDYL2 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDYL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDYL2 35
  • 99.03 (n)
  • 99.33 (a)
CDYL2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDYL2 35
  • 88.32 (n)
  • 94.26 (a)
CDYL2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CDYL2 35
  • 90.68 (n)
  • 96.78 (a)
CDYL2 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cdyl2 35
  • 85.75 (n)
  • 92.05 (a)
Cdyl2 16
Cdyl2 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDYL2 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdyl2 35
  • 87.31 (n)
  • 94.72 (a)
chicken
(Gallus gallus)
Aves CDYL2 35
  • 74.22 (n)
  • 85.77 (a)
CDYL2 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CDYL2 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdyl2 35
  • 71.49 (n)
  • 81.93 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3680 36
  • 11 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 36
  • 24 (a)
ManyToMany
ECI1 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2946 36
  • 26 (a)
OneToMany
Species with no ortholog for CDYL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for CDYL2 Gene

ENSEMBL:
Gene Tree for CDYL2 (if available)
TreeFam:
Gene Tree for CDYL2 (if available)

Paralogs for CDYL2 Gene

Paralogs for CDYL2 Gene

Selected SIMAP similar genes for CDYL2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDYL2: view

Variants for CDYL2 Gene

Sequence variations from dbSNP and Humsavar for CDYL2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1629 -- 80,607,380(-) CCAGA(A/C)CCTTG intron-variant
rs729936 -- 80,713,860(-) tctcc(A/G)tgagg intron-variant
rs735753 -- 80,613,168(+) AATTT(C/G)TATAT intron-variant
rs737176 -- 80,690,285(-) TGAGT(A/T)TGCTG intron-variant
rs737177 -- 80,690,236(-) CTGTT(C/G)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDYL2 Gene

Variant ID Type Subtype PubMed ID
esv275156 CNV Loss 21479260
esv2673789 CNV Deletion 23128226
esv268803 CNV Insertion 20981092
esv273920 CNV Insertion 20981092
esv27892 CNV Gain 19812545
esv33408 CNV Loss 17666407
nsv833301 CNV Loss 17160897
esv2636902 OTHER Inversion 19546169
esv2618788 CNV Insertion 19546169
nsv525885 CNV Loss 19592680
nsv523459 CNV Loss 19592680
nsv521339 CNV Loss 19592680
esv2675473 CNV Deletion 23128226
nsv457560 CNV Loss 19166990
esv26401 CNV Loss 19812545

Relevant External Links for CDYL2 Gene

HapMap Linkage Disequilibrium report
CDYL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDYL2 Gene

Disorders for CDYL2 Gene

(1) MalaCards Diseases for CDYL2 Gene

Search for CDYL2 Gene in MalaCards »

Relevant External Links for CDYL2

Genetic Association Database (GAD)
CDYL2
Human Genome Epidemiology (HuGE) Navigator
CDYL2
genes like me logo Genes that share disorders with CDYL2: view

No data available for UniProtKB/Swiss-Prot for CDYL2 Gene

Publications for CDYL2 Gene

  1. The CDY-related gene family: coordinated evolution in copy number, expression profile and protein sequence. (PMID: 12837688) Dorus S. … Lahn B.T. (Hum. Mol. Genet. 2003) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. (PMID: 19724895) Yoshida T. … Yamada Y. (Int. J. Mol. Med. 2009) 3 48
  4. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 48
  5. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M. … Yamada Y. (Am. J. Hypertens. 2010) 3 48

Products for CDYL2 Gene

Sources for CDYL2 Gene

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