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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDYL Gene

protein-coding   GIFtS: 60
GCID: GC06P004706

chromodomain protein, Y-like

(Previous names: chromodomain protein, Y chromosome-like )
 Explore 5 diseases affiliated with
CDYL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDYL    

Aliases
for CDYL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromodomain Protein, Y-Like1 2     CDY-Like, Autosomal2
CDYL11 2 3     Chromodomain Y-Like Protein2
EC 2.3.1.483 8     Testis-Specific Chromodomain Y-Like Protein2
DKFZP586C16221     CDY-Like1
Chromodomain Protein, Y Chromosome-Like1     

External Ids:    HGNC: 18111   Entrez Gene: 94252   Ensembl: ENSG000001530467   OMIM: 6037785   UniProtKB: Q9Y2323   
ORGUL members:         
NONCODE:n407171    

Export aliases for CDYL gene to outside databases

Previous GC identifers: GC06P004691 GC06P004651 GC06P004582


Summaries
for CDYL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDYL:
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in
infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The
Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed
gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and
gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded
by transcript variants of this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
Function: Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a preference
for histone H4




Genomic Views
for CDYL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.1  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDYL gene promoter:
         Max1   E2F-4   E2F-3a   E2F-5   AP-4   XBP-1   E2F-2   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDYL promoter sequence
   Search SABiosciences Chromatin IP Primers for CDYL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDYL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.1   Ensembl cytogenetic band:  6p25.1   HGNC cytogenetic band: 6p25.1

CDYL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDYL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P004706:  view genomic region     (about GC identifiers)

Start:
 4,706,345 bp from pter      End:
 4,955,785 bp from pter
Size:
 249,441 bases      Orientation:
 plus strand

Proteins
for CDYL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232 (See protein sequence)
Recommended Name: Chromodomain Y-like protein  
Size: 598 amino acids; 66482 Da
Subunit: Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity)
Subcellular location: Nucleus (By similarity)
Miscellaneous: Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding (By similarity)
Sequence caution: Sequence=CAB43304.1; Type=Miscellaneous discrepancy;
2 PDB 3D structures from and Proteopedia for CDYL:
2DNT (3D)        2GTR (3D)    
Secondary accessions: A8K6D6 B4DLG4 Q0VDG7 Q32NC5 Q5VX99 Q6P7T5 Q9BWZ2 Q9Y424
Alternative splicing: 4 isoforms:  Q9Y232-1   Q9Y232-2   Q9Y232-3   Q9Y232-4   

Explore the universe of human proteins at neXtProt for CDYL: NX_Q9Y232

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y232

    • 4/9 DME Specific Peptides for CDYL (Q9Y232) (see all 9)
     KALVRCN  KGLVSQVF  YLVRWKGYD  DDTWEPEQHL 

    CDYL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137442.1  NP_001137443.1  NP_004815.3  

    ENSEMBL proteins: 
     ENSP00000330512   ENSP00000394740   ENSP00000380718   ENSP00000394076   ENSP00000340908  

    Human Recombinant Protein Products: 
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    OriGene Purified Protein: CDYL
    OriGene Protein Over-expression Lysate (see all 2): CDYL
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    Novus Biologicals CDYL Proteins
    Novus Biologicals CDYL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDYL

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    CDYL for ontologies           About GeneDecksing



    CDYL Antibody Products: 
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    ThermoFisher Antibodies for CDYL

    Assay Products for CDYL: 
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    Uscn ELISAs and CLIAs for CDYL

    Protein Domains /
    Families
    for CDYL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDYL for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR001753 Crotonase_core_superfam

    Graphical View of Domain Structure for InterPro Entry Q9Y232

    ProtoNet protein and cluster: Q9Y232

    1 Blocks protein family: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
    Similarity: Contains 1 chromo domain


    Function
    for CDYL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
    Function: Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a preference
    for histone H4
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Genatlas biochemistry entry for CDYL:
    derivative of a conventional single copy CDY-like gene,1,in a AZF deleted region

    Enzyme Number (IUBMB): EC 2.3.1.481 2

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDYL
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CDYL (see all 38):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-4328 hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-let-7a-2* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: CDYL 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDYL (see all 7)
    OriGene shRNA RFP: CDYL
    OriGene siRNA: CDYL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDYL

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDYL

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CDYL (see all 8)
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    GenScript: all cDNA clones in your preferred vector (see all 3): CDYL (NM_001143970)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDYL 

    Cell Line
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    Search LifeMap BioReagents cell lines for CDYL

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDYL

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004402histone acetyltransferase activity IEA--


    CDYL for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for CDYL:
     Increased gamma-H2AX phosphory 

    Animal Models:
         1 MGI phenotypic allele for Cdyl (no phenotypes)

    CDYL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDYL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    		Transcriptional Regulatory Network in Embryonic Stem Cell1.00

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDYL
        Transcriptional Regulatory Network in Embryonic Stem Cell


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDYL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/32 Interacting proteins for CDYL (Q9Y2322, 3 ENSP000003807184) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3DP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3EP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3FP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3GP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007283spermatogenesis TAS10192397


    CDYL for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDYL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDYL

    1 HMDB Compound for CDYL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--
    Search CenterWatch for drugs/clinical trials and news about CDYL / CDYL1 

    Transcripts
    for CDYL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDYL gene (4 alternative transcripts): 
    NM_001143970.1  NM_001143971.1  NM_004824.3  NM_170752.1  

    Unigene Cluster for CDYL:

    Chromodomain protein, Y-like
    Hs.269092  [show with all ESTs]
    Unigene Representative Sequence: NM_004824
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474977 ENST00000328908(uc003mwi.3) ENST00000491864 ENST00000440139
    ENST00000483019 ENST00000397588 ENST00000472453 ENST00000449732 ENST00000343762(uc003mwj.3 uc003mwk.3 uc011dhx.2 uc011dhy.2)
    ENST00000469671

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDYL
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CDYL (see all 38):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-4328 hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-let-7a-2* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmid: CDYL 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDYL (see all 7)
    OriGene shRNA RFP: CDYL
    OriGene siRNA: CDYL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDYL
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDYL 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDYL
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDYL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDYL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDYL

    Additional cDNA sequence: 

    AF081258.1 AF081259.1 AK291601.1 AK296985.1 AL050164.1 BC043397.1 BC061516.1 BC108725.1 
    BC119682.2 NR_026590.1 

    12 DOTS entries:

    DT.446074  DT.121350936  DT.100816695  DT.97794440  DT.75131257  DT.100726877  DT.100816694  DT.100816696 
    DT.91743921  DT.97780107  DT.121350956  DT.99931849 

    24/162 AceView cDNA sequences (see all 162):

    AA599735 BX282512 NM_170751 BE220811 AA350380 BU618746 NM_170752 BQ025481 
    BC061516 BG568735 BC043397 BG779095 BG504434 AI689829 BI767492 CK821582 
    BQ059013 AW440037 CR608472 BQ930016 BU752976 AI366739 BG530365 AL050164 

    GeneLoc Exon Structure


    Expression
    for CDYL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDYL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCACTCCTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See CDYL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDYL

    SOURCE GeneReport for Unigene cluster: Hs.269092

    UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
    Tissue specificity: Ubiquitous. Expressed at moderate levels in all tissues examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDYL: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDYL

    Orthologs
    for CDYL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the last universal common ancestor (LUCA).

    Orthologs for CDYL gene from 8/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CDYL1 chromodomain protein, Y-like 80.21(n)
    90.26(a)    		   420877  XM_418964.3  XP_418964.2 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    ECHDC16
    		 --
    		 87(a)
    14(a)
    		 1 ↔ many
    possible ortholog
    		 GL343209.1(14253-102966)
    GL343681.1(204801-230877)
    zebrafish
    (Danio rerio)    		 Actinopterygii cdyl1 chromodomain protein, Y-like 66.29(n)
    70.94(a)    		   568457  XM_691787.4  XP_696879.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG138906
    		 --
    		 26(a)
    		 possible ortholog
    		 3L(851346-852673)
    worm
    (Caenorhabditis elegans)    		 Secernentea B0272.46
    C32E8.96
    		 Protein C32E8.9
    		 25(a)
    13(a)
    		 1 ↔ many
    possible ortholog
    		 X(9428372-9430264)
    I(3794556-3798056)
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ECHIA6
    		 enoyl-CoA hydratase
    		 19(a)
    		 possible ortholog
    		 4(9176673-9178048)
    rice
    (Oryza sativa)    		 Liliopsida --
    		 enoyl-CoA hydratase/isomerase family protein, puta...
    		 16(a)
    		 possible ortholog
    		 3(11067660-11070152)
    E. coli
    (Escherichia coli)    		 Gamma proteobacteria paaG6
    		 1,2-epoxyphenylacetyl-CoA isomerase, oxepin-CoA-fo...
    		 22(a)
    		 possible ortholog
    		 Chromosome(1456288-1457076)


    ENSEMBL Gene Tree for CDYL (if available)
    TreeFam Gene Tree for CDYL (if available) 

    Paralogs
    for CDYL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDYL gene
    CDY2A2  ECI22  CDY2B2  CDYL22  CDY12  CDY1B2  
    8 SIMAP similar genes for CDYL using alignment to 2 protein entries:     CDYL1_HUMAN (see all proteins):
    CDY1    CDY1B    CDY2A    CDY2B    CDYL2    ECI2
    CBX5    CBX1

    CDYL for paralogs           About GeneDecksing


    5/15 Pseudogenes.org Pseudogenes for CDYL (see all 15)
    PGOHUM00000238352 PGOHUM00000259818 PGOHUM00000241633 PGOHUM00000241634 PGOHUM00000260941


    Genomic Variants
    for CDYL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5302 NCBI SNPs in CDYL are shown (see all 5302)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 6 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs345072291,2
    		C,F,--4704493(+) CCACCT/CGCTTC 1 -- us2k15Minor allele frequency- C:0.40NA WA 10
    rs1151082121,2
    		--4704540(+) CCACAC/ACAGCC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs783357691,2
    		C,--4704638(+) TCCCAG/AAAAGG 1 -- us2k13Minor allele frequency- A:0.19WA CSA 122
    rs1487270241,2
    		--4704680(+) TCAGGC/TCCATG 1 -- us2k10--------
    rs1426587971,2
    		--4704740(+) AGTCCC/TGACTG 1 -- us2k10--------
    rs1510133751,2
    		--4704784(+) TTAATA/CACATT 1 -- us2k10--------
    rs1395467471,2
    		--4704833(+) TTGCCC/TAAGAC 1 -- us2k10--------
    rs132200591,2
    		C,--4704891(+) AGCCAA/GCTTCC 1 -- us2k14Minor allele frequency- G:0.05NA WA EA 360
    rs1444104261,2
    		--4705016(+) ATCTCA/GTGAGA 1 -- us2k10--------
    rs750242641,2
    		C,F,--4705125(+) TTGGCC/TGGGCA 1 -- us2k11Minor allele frequency- T:0.13EA 120

    HapMap Linkage Disequilibrium report for CDYL (4706345 - 4955785 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for CDYL
         1 CNV: 5223
         2 Indels: 69315 59339

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    Disorders / Diseases
    for CDYL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDYL for disorders           About GeneDecksing

    OMIM gene information: 603778    OMIM disorders: --

    5 diseases for CDYL:    About MalaCards
    gingival recession    infertility    gingivitis    copd
    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for CDYL:
    Gingival recession
    Human Genome Epidemiology (HuGE) Navigator: CDYL (1 document)

    Export disorders for CDYL gene to outside databases

    Publications
    for CDYL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDYL gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with CDYL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PubMed id 10192397)1, 2, 3, 9 Lahn B.T. and Page D.C. (1999)
    2. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. (PubMed id 12072557)1, 2 Lahn B.T....Page D.C. (2002)
    3. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. Corepressor protein CDYL functions as a molecular brid ge between polycomb repressor complex 2 and repressive chromatin mark trimethyla ted histone lysine 27. (PubMed id 22009739)1 Zhang Y....Liang J. (2011)
    6. Genome-wide association study of smoking behaviours i n patients with COPD. (PubMed id 21685187)1 Siedlinski M....Silverman E.K. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    External Searches for CDYL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CDYL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9425 HGNC: 1811 AceView: CDYL Ensembl:ENSG00000153046 euGenes: HUgn9425
    ECgene: CDYL H-InvDB: CDYL

    Other Databases showing CDYL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDYL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDYL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDYL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDYL gene:
    Search GeneIP for patents involving CDYL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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