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Aliases for CDYL Gene

Aliases for CDYL Gene

  • Chromodomain Protein, Y-Like 2 3
  • Testis-Specific Chromodomain Y-Like Protein 2 3
  • EC 2.3.1.48 4 63
  • CDY-Like 2 4
  • CDYL1 3 4
  • Chromodomain Protein, Y Chromosome-Like 2
  • Chromodomain Y-Like Protein 3
  • CDY-Like, Autosomal 3
  • Autosomal 2

External Ids for CDYL Gene

Previous GeneCards Identifiers for CDYL Gene

  • GC06P004691
  • GC06P004651
  • GC06P004582

Summaries for CDYL Gene

Entrez Gene Summary for CDYL Gene

  • Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDYL Gene

CDYL (Chromodomain Protein, Y-Like) is a Protein Coding gene. Diseases associated with CDYL include gingival recession. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include histone acetyltransferase activity and methylated histone binding. An important paralog of this gene is CDY1B.

UniProtKB/Swiss-Prot for CDYL Gene

  • Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDYL Gene

Genomics for CDYL Gene

Regulatory Elements for CDYL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CDYL Gene

Start:
4,706,159 bp from pter
End:
4,955,551 bp from pter
Size:
249,393 bases
Orientation:
Plus strand

Genomic View for CDYL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDYL Gene

Proteins for CDYL Gene

  • Protein details for CDYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y232-CDYL1_HUMAN
    Recommended name:
    Chromodomain Y-like protein
    Protein Accession:
    Q9Y232
    Secondary Accessions:
    • A8K6D6
    • B4DLG4
    • Q0VDG7
    • Q32NC5
    • Q5VX99
    • Q6P7T5
    • Q9BWZ2
    • Q9Y424

    Protein attributes for CDYL Gene

    Size:
    598 amino acids
    Molecular mass:
    66482 Da
    Quaternary structure:
    • Forms multimers and multimerization is required for stable binding to chromatin. Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity). Interacts with histone H3K9me3, histone H3K27me2 and histone H3K27me3. Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    Miscellaneous:
    • Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding.
    SequenceCaution:
    • Sequence=CAB43304.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDYL Gene

    Alternative splice isoforms for CDYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDYL Gene

Proteomics data for CDYL Gene at MOPED

Post-translational modifications for CDYL Gene

  • Ubiquitination at Lys172, Lys538, Lys576, and Lys589
  • Modification sites at PhosphoSitePlus

Other Protein References for CDYL Gene

Domains for CDYL Gene

Suggested Antigen Peptide Sequences for CDYL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y232

UniProtKB/Swiss-Prot:

CDYL1_HUMAN :
  • Q9Y232
Domain:
  • Contains 1 chromo domain.
genes like me logo Genes that share domains with CDYL: view

No data available for Gene Families for CDYL Gene

Function for CDYL Gene

Molecular function for CDYL Gene

GENATLAS Biochemistry: derivative of a conventional single copy CDY-like gene,1,in a AZF deleted region
UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
UniProtKB/Swiss-Prot Function: Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.

Enzyme Numbers (IUBMB) for CDYL Gene

Gene Ontology (GO) - Molecular Function for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003714 transcription corepressor activity IMP 19061646
GO:0003824 catalytic activity --
GO:0004402 histone acetyltransferase activity IEA --
GO:0005515 protein binding IPI 16415788
GO:0035064 NOT methylated histone binding IDA 18450745
genes like me logo Genes that share ontologies with CDYL: view

Phenotypes for CDYL Gene

GenomeRNAi human phenotypes for CDYL:
genes like me logo Genes that share phenotypes with CDYL: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDYL

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDYL Gene

Localization for CDYL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDYL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDYL Gene COMPARTMENTS Subcellular localization image for CDYL gene
Compartment Confidence
nucleus 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18450745
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with CDYL: view

Pathways for CDYL Gene

genes like me logo Genes that share pathways with CDYL: view

Pathways by source for CDYL Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Epigenetic Chromatin Modification Enzymes in human,mouse,rat
    • Epigenetic Chromatin Remodeling Factors in human,mouse,rat

Gene Ontology (GO) - Biological Process for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0007283 spermatogenesis TAS 10192397
GO:0008152 metabolic process --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with CDYL: view

Compounds for CDYL Gene

(1) HMDB Compounds for CDYL Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
genes like me logo Genes that share compounds with CDYL: view

Transcripts for CDYL Gene

Unigene Clusters for CDYL Gene

Chromodomain protein, Y-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDYL

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDYL Gene

No ASD Table

Relevant External Links for CDYL Gene

GeneLoc Exon Structure for
CDYL
ECgene alternative splicing isoforms for
CDYL

Expression for CDYL Gene

mRNA expression in normal human tissues for CDYL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDYL Gene

SOURCE GeneReport for Unigene cluster for CDYL Gene Hs.269092

mRNA Expression by UniProt/SwissProt for CDYL Gene

Q9Y232-CDYL1_HUMAN
Tissue specificity: Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform.
genes like me logo Genes that share expressions with CDYL: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for CDYL Gene

Orthologs for CDYL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDYL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDYL 35
  • 99.57 (n)
  • 99.63 (a)
CDYL 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CDYL 35
  • 82.54 (n)
  • 93.93 (a)
CDYL 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 93 (a)
OneToMany
CDYL 35
  • 90.42 (n)
  • 97.24 (a)
mouse
(Mus musculus)
Mammalia Cdyl 35
  • 86.47 (n)
  • 93.11 (a)
Cdyl 16
Cdyl 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cdyl 35
  • 86.39 (n)
  • 92.51 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 89 (a)
OneToMany
CDYL 35
  • 80.21 (n)
  • 90.26 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdyl 35
  • 72.58 (n)
  • 82.26 (a)
zebrafish
(Danio rerio)
Actinopterygii cdyl 35
  • 66.67 (n)
  • 71.46 (a)
cdyl 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3680 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 36
  • 24 (a)
ManyToMany
ECI1 36
  • 21 (a)
ManyToMany
ECI1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2946 36
  • 28 (a)
OneToMany
Species with no ortholog for CDYL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDYL Gene

ENSEMBL:
Gene Tree for CDYL (if available)
TreeFam:
Gene Tree for CDYL (if available)

Paralogs for CDYL Gene

Paralogs for CDYL Gene

Selected SIMAP similar genes for CDYL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDYL: view

Variants for CDYL Gene

Sequence variations from dbSNP and Humsavar for CDYL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs110284 -- 4,769,533(-) TTAGC(A/G)TTTTA intron-variant
rs184588 -- 4,799,819(-) caatc(A/G)tattt intron-variant
rs192061 -- 4,787,645(-) GCTCA(A/G)ACCCA intron-variant
rs233475 -- 4,800,645(-) gggca(C/T)tttca intron-variant
rs233476 -- 4,799,151(-) acaaa(G/T)caacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDYL Gene

Variant ID Type Subtype PubMed ID
nsv528627 CNV Gain 19592680
nsv819186 CNV Gain 19587683
esv2663092 CNV Deletion 23128226
esv2422499 CNV Duplication 17116639
nsv830577 CNV Loss 17160897
esv2731510 CNV Deletion 23290073
nsv462622 CNV Gain 19166990
esv23619 CNV Gain 19812545

Relevant External Links for CDYL Gene

HapMap Linkage Disequilibrium report
CDYL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDYL Gene

Disorders for CDYL Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CDYL Gene including...

Search for CDYL Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDYL Gene

Relevant External Links for CDYL

Genetic Association Database (GAD)
CDYL
Human Genome Epidemiology (HuGE) Navigator
CDYL
genes like me logo Genes that share disorders with CDYL: view

No data available for UniProtKB/Swiss-Prot for CDYL Gene

Publications for CDYL Gene

  1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PMID: 10192397) Lahn B.T. … Page D.C. (Nat. Genet. 1999) 2 3 4 23
  2. Genome-wide association study of smoking behaviours in patients with COPD. (PMID: 21685187) Siedlinski M. … . (Thorax 2011) 3 48
  3. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. (PMID: 12072557) Lahn B.T. … Page D.C. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4
  4. Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs. (PMID: 18450745) Fischle W. … Khorasanizadeh S. (J. Biol. Chem. 2008) 3 4
  5. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. (PMID: 19061646) Mulligan P. … Shi Y. (Mol. Cell 2008) 3 4

Products for CDYL Gene

  • Addgene plasmids for CDYL

Sources for CDYL Gene

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