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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDYL Gene

protein-coding   GIFtS: 63
GCID: GC06P004706

Chromodomain Protein, Y-Like

(Previous names: chromodomain protein, Y chromosome-like)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromodomain Protein, Y-Like1 2     autosomal1
CDY-like1 3     Chromodomain Protein, Y Chromosome-Like1
Testis-Specific Chromodomain Y-Like Protein1 2     CDY-Like, Autosomal2
CDYL12 3     Chromodomain Y-Like Protein2
EC 2.3.1.483 8     

External Ids:    HGNC: 18111   Entrez Gene: 94252   Ensembl: ENSG000001530467   OMIM: 6037785   UniProtKB: Q9Y2323   
ORGUL members:         
NONCODE14:n407171 n387611 n335536 n407978      

Export aliases for CDYL gene to outside databases

Previous GC identifers: GC06P004691 GC06P004651 GC06P004582


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDYL Gene:
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated
in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed.
The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the
retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in
chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation.
Multiple proteins are encoded by transcript variants of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDYL Gene: 
CDYL (chromodomain protein, Y-like) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CDYL include gingival recession, and infertility. GO annotations related to this gene include histone acetyltransferase activity. An important paralog of this gene is CDY2A.

UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
Function: Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a
preference for histone H4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NC_018917.2  NT_007592.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDYL gene promoter:
         Max1   E2F-4   E2F-3a   E2F-5   AP-4   XBP-1   E2F-2   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDYL promoter sequence
   Search SABiosciences Chromatin IP Primers for CDYL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDYL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.1   Ensembl cytogenetic band:  6p25.1   HGNC cytogenetic band: 6p25.1

CDYL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDYL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P004706:  view genomic region     (about GC identifiers)

Start:
4,706,393 bp from pter      End:
4,955,785 bp from pter
Size:
249,393 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CDYL

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232 (See protein sequence)
Recommended Name: Chromodomain Y-like protein  
Size: 598 amino acids; 66482 Da
Subunit: Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity)
Subcellular location: Nucleus (By similarity)
Miscellaneous: Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding (By similarity)
Sequence caution: Sequence=CAB43304.1; Type=Miscellaneous discrepancy;
2 PDB 3D structures from and Proteopedia for CDYL:
2DNT (3D)        2GTR (3D)    
Secondary accessions: A8K6D6 B4DLG4 Q0VDG7 Q32NC5 Q5VX99 Q6P7T5 Q9BWZ2 Q9Y424
Alternative splicing: 4 isoforms:  Q9Y232-1   Q9Y232-2   Q9Y232-3   Q9Y232-4   

Explore the universe of human proteins at neXtProt for CDYL: NX_Q9Y232

Explore proteomics data for CDYL at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y232

  • 4/9 DME Specific Peptides for CDYL (Q9Y232) (see all 9)
     KALVRCN  KGLVSQVF  YLVRWKGYD  DDTWEPEQHL 

    CDYL Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDYL Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001137442.1  NP_001137443.1  NP_004815.3  

    ENSEMBL proteins: 
     ENSP00000330512   ENSP00000394740   ENSP00000380718   ENSP00000394076   ENSP00000340908  

    Human Recombinant Protein Products for CDYL: 
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    OriGene Protein Over-expression Lysate for CDYL
    OriGene MassSpec for CDYL 
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    Novus Biologicals CDYL Proteins
    Novus Biologicals CDYL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDYL 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18450745

    CDYL for ontologies           About GeneDecksing



    CDYL Antibody Products: 
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    ThermoFisher Antibody for CDYL
    LSBio Antibodies in human, mouse, rat for CDYL 

    Assay Products for CDYL: 
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    Cloud-Clone Corp. ELISAs for CDYL 
    Cloud-Clone Corp. CLIAs for CDYL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR001753 Crotonase_core_superfam

    Graphical View of Domain Structure for InterPro Entry Q9Y232

    ProtoNet protein and cluster: Q9Y232

    1 Blocks protein domain: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
    Similarity: Contains 1 chromo domain


    CDYL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDYL1_HUMAN, Q9Y232
    Function: Acts as repressor of transcription (By similarity). Has histone acetyltransferase activity, with a
    preference for histone H4
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Genatlas biochemistry entry for CDYL:
    derivative of a conventional single copy CDY-like gene,1,in a AZF deleted region

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004402histone acetyltransferase activity IEA--
    GO:0005515protein binding IPI16415788
    GO:0035064NOT methylated histone residue binding IDA18450745
         
    CDYL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CDYL:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Cdyl (no phenotypes)

    CDYL for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDYL 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDYL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDYL 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDYL 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDYL
    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CDYL (see all 38):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-4328 hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-let-7a-2* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCDYL 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of CDYL 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CDYL
    Search LifeMap BioReagents cell lines for CDYL
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDYL


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDYL About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDYL
        Transcriptional Regulatory Network in Embryonic Stem Cell



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDYL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    5/36 Interacting proteins for CDYL (Q9Y2322, 3 ENSP000003807184) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3DP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3EP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3FP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3GP684312, 3MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0007283spermatogenesis TAS10192397
    GO:0008152metabolic process ----

    CDYL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDYL (CDYL1)

    1 HMDB Compound for CDYL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--

    Search CenterWatch for drugs/clinical trials and news about CDYL / CDYL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDYL gene (4 alternative transcripts): 
    NM_001143970.1  NM_001143971.1  NM_004824.3  NM_170752.1  

    Unigene Cluster for CDYL:

    Chromodomain protein, Y-like
    Hs.269092  [show with all ESTs]
    Unigene Representative Sequence: NM_004824
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328908(uc003mwi.3) ENST00000491864 ENST00000440139 ENST00000483019
    ENST00000397588 ENST00000472453 ENST00000449732 ENST00000343762(uc003mwj.3 uc003mwk.3 uc011dhx.2 uc011dhy.2)
    ENST00000469671
    miRNA
    Products:
         
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    8/38 QIAGEN miScript miRNA Assays for microRNAs that regulate CDYL (see all 38):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-4328 hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-let-7a-2* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCDYL 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDYL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDYL
    Clone
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    OriGene clones in human, mouse for CDYL (see all 22)
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    GenScript: all cDNA clones in your preferred vector (see all 3): CDYL (NM_001143970)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDYL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDYL
    Sirion Biotech Customized lentivirus for stable overexpression of CDYL 
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    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDYL
    OriGene qSTAR qPCR primer pairs in human, mouse for CDYL
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDYL
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDYL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDYL

    Additional mRNA sequence: 

    AF081258.1 AF081259.1 AK291601.1 AK296985.1 AL050164.1 BC043397.1 BC061516.1 BC108725.1 
    BC119682.2 NR_026590.1 

    12 DOTS entries:

    DT.446074  DT.121350936  DT.100816695  DT.97794440  DT.75131257  DT.100726877  DT.100816694  DT.100816696 
    DT.91743921  DT.97780107  DT.121350956  DT.99931849 

    24/162 AceView cDNA sequences (see all 162):

    BG779095 BU680151 BQ025481 BG568735 AI689829 NM_004824 CA770970 BE220811 
    AW440037 BQ930016 AA599735 BU618746 BE503641 CR608472 CK821582 AL050164 
    AI366739 BX282512 BQ059013 BC043397 CK821583 AW298379 AA350380 AI687116 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDYL expression in normal human tissues (normalized intensities)      CDYL embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTCCTT
    CDYL Expression
    About this image


    CDYL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Mural Trophectoderm Cells Mural Trophectoderm
     
     Amnion (Extraembryonic Tissues)
             amniotic fluid   

    See CDYL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDYL

    SOURCE GeneReport for Unigene cluster: Hs.269092

    UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
    Tissue specificity: Ubiquitous. Expressed at moderate levels in all tissues examined

        SABiosciences Expression via Pathway-Focused PCR Arrays including CDYL: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDYL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDYL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDYL gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdyl1 , 5 chromodomain protein, Y chromosome-like1, 5 86.47(n)1
    93.11(a)1
      13 (14.39 cM)5
    125931  NM_009881.31  NP_034011.11 
     356598625 
    chicken
    (Gallus gallus)
    Aves CDYL1 chromodomain protein, Y-like 80.21(n)
    90.26(a)
      420877  XM_418964.3  XP_418964.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    87(a)
    1 → many
    GL343209.1(12187-102820)
    zebrafish
    (Danio rerio)
    Actinopterygii cdyl1 chromodomain protein, Y-like 66.29(n)
    70.94(a)
      568457  XM_691787.4  XP_696879.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG138906
    --
    27(a)
    1 → many
    3L(851346-852673)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECI1(YLR284C)4 Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric more   --   12(707040-706198) 850990  NP_013386.1 


    ENSEMBL Gene Tree for CDYL (if available)
    TreeFam Gene Tree for CDYL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDYL gene
    CDY2A2  ECI22  CDY2B2  CDYL22  AUH2  ECHDC32  ECHS12  CDY1B2  
    ECHDC22  ECH12  CDY12  
    8 SIMAP similar genes for CDYL using alignment to 2 protein entries:     CDYL1_HUMAN (see all proteins):
    CDY1    CDY1B    CDY2A    CDY2B    CDYL2    ECI2
    CBX5    CBX1

    CDYL for paralogs           About GeneDecksing


    5/15 Pseudogenes.org Pseudogenes for CDYL (see all 15)
    PGOHUM00000238352 PGOHUM00000259818 PGOHUM00000241633 PGOHUM00000241634 PGOHUM00000260941


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6261 SNPs in CDYL are shown (see all 6261)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113754231,2
    C--4589887(+) TTTTT-/T/TT  
            
    GGAGA
    1 -- int1 trp30--------
    rs345072291,2
    C,F--4704493(+) CCACCT/CGCTTC 1 -- us2k15Minor allele frequency- C:0.40NA WA 10
    rs1151082121,2
    C,F--4704540(+) CCACAC/ACAGCC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs783357691,2
    C,F--4704638(+) TCCCAG/AAAAGG 1 -- us2k13Minor allele frequency- A:0.19WA CSA 122
    rs1487270241,2
    --4704680(+) TCAGGC/TCCATG 1 -- us2k10--------
    rs1426587971,2
    --4704740(+) AGTCCC/TGACTG 1 -- us2k10--------
    rs1510133751,2
    C--4704784(+) TTAATA/CACATT 1 -- us2k10--------
    rs1395467471,2
    C--4704833(+) TTGCCC/TAAGAC 1 -- us2k10--------
    rs132200591,2
    C--4704891(+) AGCCAA/GCTTCC 1 -- us2k14Minor allele frequency- G:0.05NA WA EA 360
    rs1444104261,2
    --4705016(+) ATCTCA/GTGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDYL (4706393 - 4955785 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CDYL:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2731510CNV Deletion23290073
    esv2663092CNV Deletion23128226
    esv2422499CNV Duplication17116639
    nsv830577CNV Loss17160897
    esv23619CNV Gain19812545
    nsv819186CNV Gain19587683
    nsv528627CNV Gain19592680
    nsv462622CNV Gain19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603778    OMIM disorders: --

    4 diseases for CDYL:    About MalaCards
    gingival recession    infertility    gingivitis    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for CDYL:
    Gingival recession

    CDYL for disorders           About GeneDecksing

    Genetic Association Database (GAD): CDYL
    Human Genome Epidemiology (HuGE) Navigator: CDYL (1 document)

    Export disorders for CDYL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDYL gene, integrated from 9 sources (see all 37):
    (articles sorted by number of sources associating them with CDYL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PubMed id 10192397)1, 2, 3, 9 Lahn B.T. and Page D.C. (1999)
    2. Genome-wide association study of smoking behaviours i n patients with COPD. (PubMed id 21685187)1, 4 Siedlinski M....Silverman E.K. (2011)
    3. The variant rs1867277 in FOXE1 gene confers thyroid c ancer susceptibility through the recruitment of USF1/USF2 transcription factors . (PubMed id 19730683)1, 4 Landa I....Robledo M. (2009)
    4. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. (PubMed id 12072557)1, 2 Lahn B.T....Page D.C. (2002)
    5. The functional interactome landscape of the human hist one deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (2013)
    6. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    9. Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes. (PubMed id 21258344)1 Bantscheff M....Drewes G. (2011)
    10. Corepressor protein CDYL functions as a molecular brid ge between polycomb repressor complex 2 and repressive chromatin mark trimethyla ted histone lysine 27. (PubMed id 22009739)1 Zhang Y....Liang J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9425 HGNC: 1811 AceView: CDYL Ensembl:ENSG00000153046 euGenes: HUgn9425
    ECgene: CDYL H-InvDB: CDYL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDYL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDYL gene:
    Search GeneIP for patents involving CDYL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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