Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CDYL Gene

Aliases for CDYL Gene

  • Chromodomain Protein, Y-Like 2 3 5
  • Testis-Specific Chromodomain Y-Like Protein 2 3
  • EC 2.3.1.48 4 63
  • CDY-Like 2 4
  • CDYL1 3 4
  • Chromodomain Protein, Y Chromosome-Like 2
  • CDY-Like, Autosomal 3
  • Autosomal 2

External Ids for CDYL Gene

Previous GeneCards Identifiers for CDYL Gene

  • GC06P004691
  • GC06P004651
  • GC06P004582

Summaries for CDYL Gene

Entrez Gene Summary for CDYL Gene

  • Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDYL Gene

CDYL (Chromodomain Protein, Y-Like) is a Protein Coding gene. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include transcription corepressor activity and methylated histone binding. An important paralog of this gene is CDY1B.

UniProtKB/Swiss-Prot for CDYL Gene

  • Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDYL Gene

Genomics for CDYL Gene

Regulatory Elements for CDYL Gene

Enhancers for CDYL Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDYL on UCSC Golden Path with GeneCards custom track

Genomic Location for CDYL Gene

Chromosome:
6
Start:
4,706,159 bp from pter
End:
4,955,551 bp from pter
Size:
249,393 bases
Orientation:
Plus strand

Genomic View for CDYL Gene

Genes around CDYL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDYL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDYL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDYL Gene

Proteins for CDYL Gene

  • Protein details for CDYL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y232-CDYL1_HUMAN
    Recommended name:
    Chromodomain Y-like protein
    Protein Accession:
    Q9Y232
    Secondary Accessions:
    • A8K6D6
    • B4DLG4
    • Q0VDG7
    • Q32NC5
    • Q5VX99
    • Q6P7T5
    • Q9BWZ2
    • Q9Y424

    Protein attributes for CDYL Gene

    Size:
    598 amino acids
    Molecular mass:
    66482 Da
    Quaternary structure:
    • Forms multimers and multimerization is required for stable binding to chromatin. Interacts with HDAC1 and HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity). Interacts with histone H3K9me3, histone H3K27me2 and histone H3K27me3. Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2. Part of a complex containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1, MIER2, HDAC1 and HDAC2.
    Miscellaneous:
    • Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding.
    SequenceCaution:
    • Sequence=CAB43304.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDYL Gene

    Alternative splice isoforms for CDYL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDYL Gene

Proteomics data for CDYL Gene at MOPED

Post-translational modifications for CDYL Gene

  • Ubiquitination at Lys 172, Lys 538, Lys 576, and Lys 589
  • Modification sites at PhosphoSitePlus

Other Protein References for CDYL Gene

Domains & Families for CDYL Gene

Suggested Antigen Peptide Sequences for CDYL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y232

UniProtKB/Swiss-Prot:

CDYL1_HUMAN :
  • Contains 1 chromo domain.
Domain:
  • Contains 1 chromo domain.
genes like me logo Genes that share domains with CDYL: view

No data available for Gene Families for CDYL Gene

Function for CDYL Gene

Molecular function for CDYL Gene

GENATLAS Biochemistry:
derivative of a conventional single copy CDY-like gene,1,in a AZF deleted region
UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone].
UniProtKB/Swiss-Prot Function:
Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.

Enzyme Numbers (IUBMB) for CDYL Gene

Gene Ontology (GO) - Molecular Function for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity IEA --
GO:0035064 NOT methylated histone binding IDA 18450745
genes like me logo Genes that share ontologies with CDYL: view
genes like me logo Genes that share phenotypes with CDYL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CDYL

miRNA for CDYL Gene

miRTarBase miRNAs that target CDYL

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDYL Gene

Localization for CDYL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDYL Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDYL Gene COMPARTMENTS Subcellular localization image for CDYL gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CDYL Gene

Pathways & Interactions for CDYL Gene

genes like me logo Genes that share pathways with CDYL: view

Pathways by source for CDYL Gene

Gene Ontology (GO) - Biological Process for CDYL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016573 histone acetylation IEA --
GO:1903507 negative regulation of nucleic acid-templated transcription IMP 19061646
genes like me logo Genes that share ontologies with CDYL: view

No data available for SIGNOR curated interactions for CDYL Gene

Drugs & Compounds for CDYL Gene

(1) Drugs for CDYL Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Coenzyme A Nutra 0

(1) Additional Compounds for CDYL Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
acetyl-coa
  • Ac-CoA
  • Ac-Coenzyme A
  • Ac-S-CoA
  • Ac-S-Coenzyme A
  • Acetyl coenzyme-A
72-89-9
genes like me logo Genes that share compounds with CDYL: view

Transcripts for CDYL Gene

Unigene Clusters for CDYL Gene

Chromodomain protein, Y-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDYL Gene

No ASD Table

Relevant External Links for CDYL Gene

GeneLoc Exon Structure for
CDYL
ECgene alternative splicing isoforms for
CDYL

Expression for CDYL Gene

mRNA expression in normal human tissues for CDYL Gene

Protein differential expression in normal tissues from HIPED for CDYL Gene

This gene is overexpressed in Adipocyte (39.4) and Peripheral blood mononuclear cells (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CDYL Gene



SOURCE GeneReport for Unigene cluster for CDYL Gene Hs.269092

mRNA Expression by UniProt/SwissProt for CDYL Gene

Q9Y232-CDYL1_HUMAN
Tissue specificity: Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most abundantly expressed isoform.
genes like me logo Genes that share expression patterns with CDYL: view

Protein tissue co-expression partners for CDYL Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDYL Gene

Orthologs for CDYL Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDYL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CDYL 35
  • 82.54 (n)
  • 93.93 (a)
CDYL 36
  • 89 (a)
OneToMany
dog
(Canis familiaris)
Mammalia CDYL 35
  • 90.42 (n)
  • 97.24 (a)
-- 36
  • 93 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Cdyl 35
  • 86.47 (n)
  • 93.11 (a)
Cdyl 16
Cdyl 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CDYL 35
  • 99.57 (n)
  • 99.63 (a)
CDYL 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdyl 35
  • 86.39 (n)
  • 92.51 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves CDYL 35
  • 80.21 (n)
  • 90.26 (a)
-- 36
  • 89 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 87 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cdyl 35
  • 72.58 (n)
  • 82.26 (a)
zebrafish
(Danio rerio)
Actinopterygii cdyl 35
  • 66.67 (n)
  • 71.46 (a)
cdyl 36
  • 64 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3680 36
  • 12 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 36
  • 24 (a)
ManyToMany
ECI1 36
  • 21 (a)
ManyToMany
ECI1 38
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2946 36
  • 28 (a)
OneToMany
Species with no ortholog for CDYL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDYL Gene

ENSEMBL:
Gene Tree for CDYL (if available)
TreeFam:
Gene Tree for CDYL (if available)

Paralogs for CDYL Gene

Paralogs for CDYL Gene

(8) SIMAP similar genes for CDYL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDYL: view

Variants for CDYL Gene

Sequence variations from dbSNP and Humsavar for CDYL Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs3812179 - 4,715,782(-) AAATG(C/T)CATAA nc-transcript-variant
rs3812178 - 4,715,803(-) GGCTG(A/G)CCTGT nc-transcript-variant
rs13196069 - 4,734,801(+) CTCCG(C/T)GAGCA nc-transcript-variant
rs28360500 - 4,734,837(+) TCCCG(C/G)TTTAC nc-transcript-variant
rs1016877 -- 4,819,771(-) tggct(A/G)tgacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CDYL Gene

Variant ID Type Subtype PubMed ID
nsv528627 CNV Gain 19592680
nsv819186 CNV Gain 19587683
esv2663092 CNV Deletion 23128226
esv2422499 CNV Duplication 17116639
nsv830577 CNV Loss 17160897
esv2731510 CNV Deletion 23290073
nsv462622 CNV Gain 19166990
esv23619 CNV Gain 19812545

Variation tolerance for CDYL Gene

Residual Variation Intolerance Score: 12.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDYL Gene

HapMap Linkage Disequilibrium report
CDYL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDYL Gene

Disorders for CDYL Gene

Relevant External Links for CDYL

Genetic Association Database (GAD)
CDYL
Human Genome Epidemiology (HuGE) Navigator
CDYL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDYL

No disorders were found for CDYL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDYL Gene

Publications for CDYL Gene

  1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PMID: 10192397) Lahn B.T. … Page D.C. (Nat. Genet. 1999) 2 3 4 23 67
  2. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. Coordinated regulation of dendrite arborization by epigenetic factors CDYL and EZH2. (PMID: 24671995) Qi C. … Liang J. (J. Neurosci. 2014) 3

Products for CDYL Gene

Sources for CDYL Gene

Content