Aliases for CDYL Gene
External Ids for CDYL Gene
Previous GeneCards Identifiers for CDYL Gene
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed. The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation. Multiple proteins are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDYL Gene
CDYL (Chromodomain Y Like) is a Protein Coding gene. Among its related pathways are Mesodermal Commitment Pathway and Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include transcription corepressor activity and methylated histone binding. An important paralog of this gene is CDY1B.
UniProtKB/Swiss-Prot for CDYL Gene
Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4.