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CDYL Gene

protein-coding   GIFtS: 62
GCID: GC06P004706

Chromodomain Protein, Y-Like

(Previous names: chromodomain protein, Y chromosome-like)
  See CDYL-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromodomain Protein, Y-Like1 2     autosomal1
CDY-like1 3     Chromodomain Protein, Y Chromosome-Like1
Testis-Specific Chromodomain Y-Like Protein1 2     CDY-Like, Autosomal2
CDYL12 3     Chromodomain Y-Like Protein2
EC 2.3.1.483 8     

External Ids:    HGNC: 18111   Entrez Gene: 94252   Ensembl: ENSG000001530467   OMIM: 6037785   UniProtKB: Q9Y2323   

Export aliases for CDYL gene to outside databases

Previous GC identifers: GC06P004691 GC06P004651 GC06P004582


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDYL Gene:
Chromodomain Y is a primate-specific Y-chromosomal gene family expressed exclusively in the testis and implicated
in infertility. Although the Y-linked genes are testis-specific, this autosomal gene is ubiquitously expressed.
The Y-linked genes arose by retrotransposition of an mRNA from this gene, followed by amplification of the
retroposed gene. Proteins encoded by this gene superfamily possess a chromodomain, a motif implicated in
chromatin binding and gene suppression, and a catalytic domain believed to be involved in histone acetylation.
Multiple proteins are encoded by transcript variants of this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDYL Gene:
CDYL (chromodomain protein, Y-like) is a protein-coding gene. Diseases associated with CDYL include gingival recession. GO annotations related to this gene include histone acetyltransferase activity and methylated histone residue binding. An important paralog of this gene is CDY2A.

UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
Function: Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine
N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for
chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive
regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring
nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDYL gene promoter:
         Max1   E2F-4   E2F-3a   E2F-5   AP-4   XBP-1   E2F-2   c-Ets-1   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDYL promoter sequence
   Search Chromatin IP Primers for CDYL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDYL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p25.1   Ensembl cytogenetic band:  6p25.1   HGNC cytogenetic band: 6p25.1

CDYL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDYL gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P004706:  view genomic region     (about GC identifiers)

Start:
4,706,393 bp from pter      End:
4,955,785 bp from pter
Size:
249,393 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for CDYL

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232 (See protein sequence)
Recommended Name: Chromodomain Y-like protein  
Size: 598 amino acids; 66482 Da
Subunit: Forms multimers and multimerization is required for stable binding to chromatin. Interacts with HDAC1 and
HDAC2 via its C-terminal acetyl-CoA-binding domain (By similarity). Interacts with histone H3K9me3, histone
H3K27me2 and histone H3K27me3. Interacts with EZH2, EED, SUZ12, REST, EHMT1 and EHMT2. Part of a complex
containing at least CDYL, REST, WIZ, SETB1, EHMT1 and EHMT2. Part of a complex containing at least CDYL, MIER1,
MIER2, HDAC1 and HDAC2
Miscellaneous: Interaction with HDAC1 or HDAC2 prevents Coenzyme A binding (By similarity)
Sequence caution: Sequence=CAB43304.1; Type=Miscellaneous discrepancy;
2 PDB 3D structures from and Proteopedia for CDYL:
2DNT (3D)        2GTR (3D)    
Secondary accessions: A8K6D6 B4DLG4 Q0VDG7 Q32NC5 Q5VX99 Q6P7T5 Q9BWZ2 Q9Y424
Alternative splicing: 4 isoforms:  Q9Y232-1   Q9Y232-2   Q9Y232-3   Q9Y232-4   

Explore the universe of human proteins at neXtProt for CDYL: NX_Q9Y232

Explore proteomics data for CDYL at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys172, Lys538, Lys576, Lys589
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CDYL (Q9Y232) (see all 9)
     KALVRCN  KGLVSQVF  YLVRWKGYD  DDTWEPEQHL 


    See CDYL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001137442.1  NP_001137443.1  NP_004815.3  

    ENSEMBL proteins: 
     ENSP00000330512   ENSP00000394740   ENSP00000380718   ENSP00000394076   ENSP00000340908  

    CDYL Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for CDYL
    OriGene MassSpec for CDYL
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    Novus Biologicals CDYL Proteins
    Novus Biologicals CDYL Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDYL

     
    Search eBioscience for Proteins for CDYL 

     
    antibodies-online proteins for CDYL (6 products) 

     
    antibodies-online peptides for CDYL

    CDYL Antibody Products:

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    antibodies-online antibodies for CDYL (24 products) 

    CDYL Assay Products:

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    Cloud-Clone Corp. ELISAs for CDYL
    Cloud-Clone Corp. CLIAs for CDYL
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    antibodies-online kits for CDYL (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR000953 Chromo_domain/shadow
     IPR023780 Chromo_domain
     IPR016197 Chromodomain-like
     IPR023779 Chromodomain_CS
     IPR001753 Crotonase_core_superfam

    Graphical View of Domain Structure for InterPro Entry Q9Y232

    ProtoNet protein and cluster: Q9Y232

    1 Blocks protein domain: IPB000953 Chromo domain

    UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
    Similarity: Contains 1 chromo domain


    Find genes that share domains with CDYL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDYL1_HUMAN, Q9Y232
    Function: Acts as a RE1-silencing transcription factor (REST) corepressor that facilitates histone-lysine
    N-methyltransferase EHMT2 recruitment and H3K9 dimethylation at REST target genes for repression. Required for
    chromatin targeting and maximal enzymatic activity of polycomb repressive complex 2 (PRC2); acts as a positive
    regulator of PRC2 activity by bridging the pre-existing histone H3K27me3 and newly recruited PRC2 on neighboring
    nucleosomes. Has histone acetyltransferase activity, with a preference for histone H4
    Catalytic activity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]

         Genatlas biochemistry entry for CDYL:
    derivative of a conventional single copy CDY-like gene,1,in a AZF deleted region

         Enzyme Number (IUBMB): EC 2.3.1.481 2

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity IMP19061646
    GO:0003824catalytic activity ----
    GO:0004402histone acetyltransferase activity IEA--
    GO:0005515protein binding IPI16415788
    GO:0035064NOT methylated histone residue binding IDA18450745
         
    Find genes that share ontologies with CDYL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CDYL:
     Increased gamma-H2AX phosphory 

         1 MGI phenotypic allele for Cdyl (no phenotypes)

    Find genes that share phenotypes with CDYL           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CDYL

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CDYL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDYL (see all 38):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-4328 hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-let-7a-2* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCDYL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CDYL
    Predesigned siRNA for gene silencing in human, mouse, rat CDYL

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDYL

    Clone
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    OriGene clones in human, mouse for CDYL (see all 25)
    OriGene ORF clones in mouse, rat for CDYL
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDYL (NM_001143970)
    Sino Biological Human cDNA Clone for CDYL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDYL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDYL
    Addgene plasmids for CDYL 

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CDYL 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDYL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDYL1_HUMAN, Q9Y232: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    endoplasmic reticulum1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA18450745

    Find genes that share ontologies with CDYL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDYL About    
    See pathways by source

    SuperPathContained pathways About
    1Transcriptional Regulatory Network in Embryonic Stem Cell
    Transcriptional Regulatory Network in Embryonic Stem Cell

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDYL
        Transcriptional Regulatory Network in Embryonic Stem Cell



        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDYL: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CDYL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDYL (Q9Y2321, 2, 3 ENSP000003807184) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684311, 2, 3EBI-1387386,EBI-79722 MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3DP684311, 2, 3EBI-1387386,EBI-79722 MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3EP684311, 2, 3EBI-1387386,EBI-79722 MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3FP684311, 2, 3EBI-1387386,EBI-79722 MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    HIST1H3GP684311, 2, 3EBI-1387386,EBI-79722 MINT-2830893 MINT-2829980 MINT-2829819 MINT-2830038 MINT-2830637 I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0007283spermatogenesis TAS10192397
    GO:0008152metabolic process ----

    Find genes that share ontologies with CDYL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDYL (CDYL1)

    1 HMDB Compound for CDYL    About this table
    CompoundSynonyms CAS #PubMed Ids
    Acetyl-CoAS-Acetyl coenzyme A (see all 13)72-89-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CDYL gene (4 alternative transcripts): 
    NM_001143970.1  NM_001143971.1  NM_004824.3  NM_170752.1  

    Unigene Cluster for CDYL:

    Chromodomain protein, Y-like
    Hs.269092  [show with all ESTs]
    Unigene Representative Sequence: NM_004824
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000328908(uc003mwi.3) ENST00000491864 ENST00000440139 ENST00000483019
    ENST00000397588 ENST00000472453 ENST00000449732 ENST00000343762(uc003mwj.3 uc003mwk.3 uc011dhx.2 uc011dhy.2)
    ENST00000469671
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CDYL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CDYL (see all 38):
    hsa-miR-142-5p hsa-miR-140-5p hsa-miR-4328 hsa-miR-429 hsa-miR-513a-5p hsa-miR-485-3p hsa-let-7a-2* hsa-miR-200b
    SwitchGear 3'UTR luciferase reporter plasmidCDYL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CDYL
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CDYL (NM_001143970)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDYL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDYL
    Addgene plasmids for CDYL 
    Primer
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    OriGene qPCR primer pairs and template standards for CDYL
    OriGene qSTAR qPCR primer pairs in human, mouse for CDYL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDYL
      QuantiTect SYBR Green Assays in human, mouse, rat CDYL
      QuantiFast Probe-based Assays in human, mouse, rat CDYL

    Additional mRNA sequence: 

    AF081258.1 AF081259.1 AK291601.1 AK296985.1 AL050164.1 BC043397.1 BC061516.1 BC108725.1 
    BC119682.2 NR_026590.1 

    12 DOTS entries:

    DT.446074  DT.121350936  DT.100816695  DT.97794440  DT.75131257  DT.100726877  DT.100816694  DT.100816696 
    DT.91743921  DT.97780107  DT.121350956  DT.99931849 

    Selected AceView cDNA sequences (see all 162):

    BX282512 AA173196 BQ002289 BE503641 BU680151 BC043397 BC061516 BG779095 
    CR608472 BQ930016 BU752976 AA418672 BQ721536 BQ025481 CK821583 BU618746 
    AA350380 AI687116 BQ059013 AL050164 AI689829 BG530365 AI366739 BI767492 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDYL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCACTCCTT
    CDYL Expression
    About this image


    CDYL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CDYL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDYL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.269092

    UniProtKB/Swiss-Prot: CDYL1_HUMAN, Q9Y232
    Tissue specificity: Ubiquitous. Expressed at moderate levels in all tissues examined. Isoform 2 is the most
    abundantly expressed isoform

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CDYL: 
              Epigenetic Chromatin Modification Enzymes in human mouse rat
              Epigenetic Chromatin Remodeling Factors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDYL
    OriGene qSTAR qPCR primer pairs in human, mouse for CDYL
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDYL
    QuantiTect SYBR Green Assays in human, mouse, rat CDYL
    QuantiFast Probe-based Assays in human, mouse, rat CDYL
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDYL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CDYL gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdyl1 , 5 chromodomain protein, Y chromosome-like1, 5 86.47(n)1
    93.11(a)1
      13 (14.39 cM)5
    125931  NM_009881.31  NP_034011.11 
     356598625 
    chicken
    (Gallus gallus)
    Aves CDYL1 chromodomain protein, Y-like 80.21(n)
    90.26(a)
      420877  XM_418964.4  XP_418964.2 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    87(a)
    1 → many
    GL343209.1(12187-102820)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cdyl1 chromodomain protein, Y-like 72.58(n)
    82.26(a)
      100491952  XM_002936429.2  XP_002936475.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cdyl1 chromodomain protein, Y-like 66.67(n)
    71.46(a)
      568457  XM_691787.5  XP_696879.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG36806
    --
    12(a)
    1 → many
    3L(20802769-20806432)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ECI1(YLR284C)4 Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric more   --   12(707040-706198) 850990  NP_013386.1 


    ENSEMBL Gene Tree for CDYL (if available)
    TreeFam Gene Tree for CDYL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CDYL gene
    CDY2A2  ECI22  CDY2B2  CDYL22  AUH2  ECHDC32  ECHS12  CDY1B2  
    ECHDC22  ECH12  CDY12  
    8 SIMAP similar genes for CDYL using alignment to 2 protein entries:     CDYL1_HUMAN (see all proteins):
    CDY1    CDY1B    CDY2A    CDY2B    CDYL2    ECI2
    CBX5    CBX1

    Find genes that share paralogs with CDYL           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CDYL (see all 15)
    PGOHUM00000238352 PGOHUM00000259818 PGOHUM00000241633 PGOHUM00000241634 PGOHUM00000260941


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDYL (see all 6261)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113754231,2
    C--4589887(+) TTTTT-/T/TT  
            
    GGAGA
    1 -- int1 trp30--------
    rs345072291,2
    C,F--4704493(+) CCACCT/CGCTTC 1 -- us2k15Minor allele frequency- C:0.40NA WA 10
    rs1151082121,2
    C,F--4704540(+) CCACAC/ACAGCC 1 -- us2k11Minor allele frequency- A:0.01NA 120
    rs783357691,2
    C,F--4704638(+) TCCCAG/AAAAGG 1 -- us2k13Minor allele frequency- A:0.19WA CSA 122
    rs1487270241,2
    --4704680(+) TCAGGC/TCCATG 1 -- us2k10--------
    rs1426587971,2
    --4704740(+) AGTCCC/TGACTG 1 -- us2k10--------
    rs1510133751,2
    C--4704784(+) TTAATA/CACATT 1 -- us2k10--------
    rs1395467471,2
    C--4704833(+) TTGCCC/TAAGAC 1 -- us2k10--------
    rs132200591,2
    C--4704891(+) AGCCAA/GCTTCC 1 -- us2k14Minor allele frequency- G:0.05NA WA EA 360
    rs1444104261,2
    --4705016(+) ATCTCA/GTGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDYL (4706393 - 4955785 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CDYL:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731510CNV Deletion23290073
    esv2663092CNV Deletion23128226
    esv2422499CNV Duplication17116639
    nsv830577CNV Loss17160897
    esv23619CNV Gain19812545
    nsv819186CNV Gain19587683
    nsv528627CNV Gain19592680
    nsv462622CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDYL
    DNA2.0 Custom Variant and Variant Library Synthesis for CDYL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603778    OMIM disorders: --

    1 disease for CDYL:    
    About MalaCards
    gingival recession

    1 disease from the University of Copenhagen DISEASES database for CDYL:
    Gingival recession

    Find genes that share disorders with CDYL           About GenesLikeMe

    Genetic Association Database (GAD): CDYL
    Human Genome Epidemiology (HuGE) Navigator: CDYL (1 document)

    Export disorders for CDYL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CDYL gene, integrated from 10 sources (see all 40):
    (articles sorted by number of sources associating them with CDYL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PubMed id 10192397)1, 2, 3, 9 Lahn B.T. and Page D.C. (Nat. Genet. 1999)
    2. Genome-wide association study of smoking behaviours in patients with COPD. (PubMed id 21685187)1, 4 Siedlinski M.... . (Thorax 2011)
    3. Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27. (PubMed id 22009739)1, 2 Zhang Y....Liang J. (J. Biol. Chem. 2011)
    4. Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association. (PubMed id 19808672)1, 2 Franz H....Fischle W. (J. Biol. Chem. 2009)
    5. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    6. Specificity of the chromodomain Y chromosome family of chromodomains for lysine-methylated ARK(S/T) motifs. (PubMed id 18450745)1, 2 Fischle W....Khorasanizadeh S. (J. Biol. Chem. 2008)
    7. CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation. (PubMed id 19061646)1, 2 Mulligan P....Shi Y. (Mol. Cell 2008)
    8. Previously uncharacterized histone acetyltransferases implicated in mammalian spermatogenesis. (PubMed id 12072557)1, 2 Lahn B.T....Page D.C. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Short-Form CDYLb but not long-form CDYLa functions cooperatively with histone methyltransferase G9a in hepatocellular carcinomas. (PubMed id 23629948)1 Wu H....Yu X. (amp 2013)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9425 HGNC: 1811 AceView: CDYL Ensembl:ENSG00000153046 euGenes: HUgn9425
    ECgene: CDYL H-InvDB: CDYL

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CDYL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CDYL gene:
    Search GeneIP for patents involving CDYL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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