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Aliases for CDY2B Gene

Aliases for CDY2B Gene

  • Chromodomain Protein, Y-Linked, 2B 2 3
  • EC 2.3.1.48 4 63
  • Testis-Specific Chromodomain Protein Y Protein 2 Related 3
  • Chromodomain Protein, Y Chromosome, 2 Related 3
  • Testis-Specific Chromodomain Protein Y 2 3
  • Y Chromosome Chromodomain Protein 2B 3
  • CDY2A CDY2B 4
  • CDY2 4
  • CDY 3

External Ids for CDY2B Gene

Previous GeneCards Identifiers for CDY2B Gene

  • GC0YM018428
  • GC0YM018499
  • GC0YM019990

Summaries for CDY2B Gene

Entrez Gene Summary for CDY2B Gene

  • This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDY2B Gene

CDY2B (Chromodomain Protein, Y-Linked, 2B) is a Protein Coding gene. GO annotations related to this gene include histone acetyltransferase activity. An important paralog of this gene is CDY1B.

UniProtKB/Swiss-Prot for CDY2B Gene

  • May have histone acetyltransferase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDY2B Gene

Genomics for CDY2B Gene

Genomic Location for CDY2B Gene

Start:
17,877,410 bp from pter
End:
17,880,220 bp from pter
Size:
2,811 bases
Orientation:
Minus strand

Genomic View for CDY2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDY2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDY2B Gene

Proteins for CDY2B Gene

  • Protein details for CDY2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F7-CDY2_HUMAN
    Recommended name:
    Testis-specific chromodomain protein Y 2
    Protein Accession:
    Q9Y6F7
    Secondary Accessions:
    • A8K868

    Protein attributes for CDY2B Gene

    Size:
    541 amino acids
    Molecular mass:
    60524 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDY2B Gene

neXtProt entry for CDY2B Gene

Proteomics data for CDY2B Gene at MOPED

Post-translational modifications for CDY2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDY2B Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CDY2B Gene

Suggested Antigen Peptide Sequences for CDY2B Gene

Graphical View of Domain Structure for InterPro Entry

Q9Y6F7

UniProtKB/Swiss-Prot:

CDY2_HUMAN :
  • Q9Y6F7
Domain:
  • Contains 1 chromo domain.
genes like me logo Genes that share domains with CDY2B: view

No data available for Gene Families for CDY2B Gene

Function for CDY2B Gene

Molecular function for CDY2B Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Acetyl-CoA + [histone] = CoA + acetyl-[histone]
UniProtKB/Swiss-Prot Function:
May have histone acetyltransferase activity.

Enzyme Numbers (IUBMB) for CDY2B Gene

Gene Ontology (GO) - Molecular Function for CDY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004402 histone acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with CDY2B: view

Animal Model Products

CRISPR Products

miRNA for CDY2B Gene

miRTarBase miRNAs that target CDY2B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDY2B

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CDY2B Gene

Localization for CDY2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDY2B Gene

Gene Ontology (GO) - Cellular Components for CDY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CDY2B: view

No data available for Subcellular locations from COMPARTMENTS for CDY2B Gene

Pathways for CDY2B Gene

SuperPathways for CDY2B Gene

No Data Available

Interacting Proteins for CDY2B Gene

Gene Ontology (GO) - Biological Process for CDY2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 9381176
GO:0008152 metabolic process --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with CDY2B: view

No data available for Pathways by source for CDY2B Gene

Transcripts for CDY2B Gene

mRNA/cDNA for CDY2B Gene

(2) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CDY2B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDY2B Gene

No ASD Table

Relevant External Links for CDY2B Gene

GeneLoc Exon Structure for
CDY2B
ECgene alternative splicing isoforms for
CDY2B

Expression for CDY2B Gene

mRNA expression in normal human tissues for CDY2B Gene

Protein differential expression in normal tissues for CDY2B Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDY2B Gene

SOURCE GeneReport for Unigene cluster for CDY2B Gene Hs.532657

mRNA Expression by UniProt/SwissProt for CDY2B Gene

Q9Y6F7-CDY2_HUMAN
Tissue specificity: Testis specific
genes like me logo Genes that share expressions with CDY2B: view

Expression partners for CDY2B Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CDY2B Gene

Orthologs for CDY2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDY2B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDY1 35
  • 98.15 (n)
  • 95.93 (a)
-- 36
  • 92 (a)
ManyToMany
-- 36
  • 92 (a)
ManyToMany
-- 36
  • 92 (a)
ManyToMany
CDY1 36
  • 92 (a)
ManyToMany
CDY1 36
  • 89 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CDYL 36
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cdyl 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3680 36
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 36
  • 22 (a)
ManyToMany
ECI1 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2946 36
  • 26 (a)
OneToMany
Species with no ortholog for CDY2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDY2B Gene

ENSEMBL:
Gene Tree for CDY2B (if available)
TreeFam:
Gene Tree for CDY2B (if available)

Paralogs for CDY2B Gene

Paralogs for CDY2B Gene

Selected SIMAP similar genes for CDY2B Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDY2B: view

Variants for CDY2B Gene

Sequence variations from dbSNP and Humsavar for CDY2B Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs3992878 -- 17,880,570(+) ctcca(C/G)cctcg upstream-variant-2KB
rs374343845 -- 17,880,120(+) GTCTC(A/G)TGGTG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CDY2B Gene

Variant ID Type Subtype PubMed ID
nsv469874 CNV Complex 16826518
esv1670141 OTHER Inversion 17803354

Relevant External Links for CDY2B Gene

HapMap Linkage Disequilibrium report
CDY2B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDY2B Gene

Disorders for CDY2B Gene

No disorders were found for CDY2B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CDY2B Gene

Publications for CDY2B Gene

  1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PMID: 10192397) Lahn B.T. … Page D.C. (Nat. Genet. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Functional coherence of the human Y chromosome. (PMID: 9381176) Lahn B.T. … Page D.C. (Science 1997) 2 3
  4. A long-range restriction map of deletion interval 6 of the human Y chromosome: a region frequently deleted in azoospermic males. (PMID: 9806824) Yen P.H. (Genomics 1998) 3
  5. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3

Products for CDY2B Gene

Sources for CDY2B Gene

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