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Aliases for CDY2A Gene

Aliases for CDY2A Gene

  • Chromodomain Protein, Y-Linked, 2A 2 3
  • CDY2 3 4 6
  • Chromodomain Protein, Y Chromosome, 2 2 3
  • EC 2.3.1.48 4 64
  • Testis-Specific Chromodomain Protein Y 2 3
  • Y Chromosome Chromodomain Protein 2A 3
  • Chromodomain Protein, Y-Linked, 2 2
  • CDY2A CDY2B 4
  • CDY 3

External Ids for CDY2A Gene

Previous Symbols for CDY2A Gene

  • CDY2

Summaries for CDY2A Gene

Entrez Gene Summary for CDY2A Gene

  • This intronless gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. Two nearly identical copies of this gene are found in a palindromic region on chromosome Y; this record represents the telomeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. [provided by RefSeq, Jul 2008]

GeneCards Summary for CDY2A Gene

CDY2A (Chromodomain Protein, Y-Linked, 2A) is a Protein Coding gene. Diseases associated with CDY2A include y chromosome infertility. An important paralog of this gene is CDY1B.

UniProtKB/Swiss-Prot for CDY2A Gene

  • May have histone acetyltransferase activity.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDY2A Gene

Genomics for CDY2A Gene

Genomic Location for CDY2A Gene

Start:
18,025,787 bp from pter
End:
18,028,597 bp from pter
Size:
2,811 bases
Orientation:
Plus strand

Genomic View for CDY2A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CDY2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDY2A Gene

Proteins for CDY2A Gene

  • Protein details for CDY2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y6F7-CDY2_HUMAN
    Recommended name:
    Testis-specific chromodomain protein Y 2
    Protein Accession:
    Q9Y6F7
    Secondary Accessions:
    • A8K868

    Protein attributes for CDY2A Gene

    Size:
    541 amino acids
    Molecular mass:
    60524 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CDY2A Gene

neXtProt entry for CDY2A Gene

Proteomics data for CDY2A Gene at MOPED

Post-translational modifications for CDY2A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDY2A Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains for CDY2A Gene

UniProtKB/Swiss-Prot:

CDY2_HUMAN
Domain:
  • Contains 1 chromo domain.:
    • Q9Y6F7
genes like me logo Genes that share domains with CDY2A: view

No data available for Gene Families for CDY2A Gene

Function for CDY2A Gene

Molecular function for CDY2A Gene

UniProtKB/Swiss-Prot CatalyticActivity: Acetyl-CoA + [histone] = CoA + acetyl-[histone]
UniProtKB/Swiss-Prot Function: May have histone acetyltransferase activity.

Enzyme Numbers (IUBMB) for CDY2A Gene

Gene Ontology (GO) - Molecular Function for CDY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity --
GO:0004402 histone acetyltransferase activity IEA --
genes like me logo Genes that share ontologies with CDY2A: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CDY2A Gene

Localization for CDY2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDY2A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDY2A Gene COMPARTMENTS Subcellular localization image for CDY2A gene
Compartment Confidence
nucleus 3
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CDY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with CDY2A: view

Pathways for CDY2A Gene

SuperPathways for CDY2A Gene

No Data Available

Interacting Proteins for CDY2A Gene

Gene Ontology (GO) - Biological Process for CDY2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007283 spermatogenesis TAS 9381176
GO:0008152 metabolic process --
GO:0016573 histone acetylation IEA --
genes like me logo Genes that share ontologies with CDY2A: view

No data available for Pathways by source for CDY2A Gene

Compounds for CDY2A Gene

(2) HMDB Compounds for CDY2A Gene

Compound Synonyms Cas Number PubMed IDs
Acetyl-CoA
  • S-Acetyl coenzyme A
72-89-9
Coenzyme A
  • Acetoacetyl coenzyme A sodium salt
85-61-0
genes like me logo Genes that share compounds with CDY2A: view

Transcripts for CDY2A Gene

mRNA/cDNA for CDY2A Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CDY2A Gene

Chromodomain protein, Y-linked, 2A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CDY2A Gene

No ASD Table

Relevant External Links for CDY2A Gene

GeneLoc Exon Structure for
CDY2A
ECgene alternative splicing isoforms for
CDY2A

Expression for CDY2A Gene

mRNA expression in normal human tissues for CDY2A Gene

mRNA differential expression in normal tissues according to GTEx for CDY2A Gene

This gene is overexpressed in Testis (53.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CDY2A Gene

SOURCE GeneReport for Unigene cluster for CDY2A Gene Hs.251375

mRNA Expression by UniProt/SwissProt for CDY2A Gene

Q9Y6F7-CDY2_HUMAN
Tissue specificity: Testis specific
genes like me logo Genes that share expressions with CDY2A: view

Orthologs for CDY2A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CDY2A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 37
  • 92 (a)
ManyToMany
-- 37
  • 92 (a)
ManyToMany
-- 37
  • 92 (a)
ManyToMany
CDY1 36
  • 98.15 (n)
  • 95.93 (a)
CDY1 37
  • 92 (a)
ManyToMany
CDY1 37
  • 89 (a)
ManyToMany
cow
(Bos Taurus)
Mammalia CDYL 37
  • 59 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 61 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 60 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 59 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 37
  • 61 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 60 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii cdyl 37
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG3680 37
  • 9 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DCI1 37
  • 22 (a)
ManyToMany
ECI1 37
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2946 37
  • 26 (a)
OneToMany
Species with no ortholog for CDY2A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDY2A Gene

ENSEMBL:
Gene Tree for CDY2A (if available)
TreeFam:
Gene Tree for CDY2A (if available)

Paralogs for CDY2A Gene

Paralogs for CDY2A Gene

Selected SIMAP similar genes for CDY2A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CDY2A: view

Variants for CDY2A Gene

Sequence variations from dbSNP and Humsavar for CDY2A Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs200670724 -- 18,025,744(+) CCATA(C/T)AATCG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDY2A Gene

Variant ID Type Subtype PubMed ID
nsv469874 CNV Complex 16826518
esv1670141 OTHER Inversion 17803354

Relevant External Links for CDY2A Gene

HapMap Linkage Disequilibrium report
CDY2A

Disorders for CDY2A Gene

(1) MalaCards Diseases for CDY2A Gene

Search for CDY2A Gene in MalaCards »

(1) University of Copenhagen DISEASES for CDY2A Gene

genes like me logo Genes that share disorders with CDY2A: view

No data available for UniProtKB/Swiss-Prot for CDY2A Gene

Publications for CDY2A Gene

  1. Retroposition of autosomal mRNA yielded testis-specific gene family on human Y chromosome. (PMID: 10192397) Lahn B.T. … Page D.C. (Nat. Genet. 1999) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Y Chromosome Infertility (PMID: 20301513) Pagon R.A. … Stephens K. ( 1993) 3
  4. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3
  5. Deletion or underexpression of the Y-chromosome genes CDY2 and HSFY is associated with maturation arrest in American men with nonobstructive azoospermia. (PMID: 22820855) Stahl P.J. … Paduch D.A. (Asian J. Androl. 2012) 3

Products for CDY2A Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate CDY2A
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CDY2A
    • Block miRNA regulation of CDY2A using miScript Target Protectors

    Sources for CDY2A Gene

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