Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDX4 Gene

protein-coding   GIFtS: 50
GCID: GC0XP072583

Caudal Type Homeobox 4

(Previous name: caudal type homeo box transcription factor 4)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caudal Type Homeobox 41 2
Caudal-Type Homeobox Protein 42 3
Caudal Type Homeo Box Transcription Factor 41
Caudal Type Homeobox Transcription Factor 42
Homeobox Protein CDX-42

External Ids:    HGNC: 18081   Entrez Gene: 10462   Ensembl: ENSG000001312647   OMIM: 3000255   UniProtKB: O146273   

Export aliases for CDX4 gene to outside databases

Previous GC identifers: GC0XP068480 GC0XP069841 GC0XP070881 GC0XP071533 GC0XP072450 GC0XP066300


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDX4 Gene:
This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein
may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. (provided by RefSeq,
Aug 2012)

GeneCards Summary for CDX4 Gene: 
CDX4 (caudal type homeobox 4) is a protein-coding gene. Diseases associated with CDX4 include adult acute lymphocytic leukemia, and acute lymphocytic leukemia. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CDX1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.2  NT_011669.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDX4 gene promoter:
         Sox5   Pax-2b   HTF   Pax-2   FOXO1a   FOXD3   IRF-7A   Pax-2a   Cdc5   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for CDX4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDX4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq13.2   Ensembl cytogenetic band:  Xq13.2   HGNC cytogenetic band: Xq13.2

CDX4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDX4 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP072583:  view genomic region     (about GC identifiers)

Start:
72,667,090 bp from pter      End:
72,675,081 bp from pter
Size:
7,992 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDX4_HUMAN, O14627 (See protein sequence)
Recommended Name: Homeobox protein CDX-4  
Size: 284 amino acids; 30480 Da
Subcellular location: Nucleus (By similarity)
Secondary accessions: A1A513 Q5JS20

Explore the universe of human proteins at neXtProt for CDX4: NX_O14627

Explore proteomics data for CDX4 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14627

  • CDX4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDX4 Protein Expression
    REFSEQ proteins: NP_005184.1  
    ENSEMBL proteins: 
     ENSP00000362613  

    Human Recombinant Protein Products for CDX4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CDX4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CDX4
    GenScript Custom Purified and Recombinant Proteins Services for CDX4
    Novus Biologicals CDX4 Protein
    Novus Biologicals CDX4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDX4 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CDX4 for ontologies           About GeneDecksing



    CDX4 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CDX4
    R&D Systems Antibodies for CDX4
    OriGene Antibodies for CDX4
    OriGene Custom Antibody Services for CDX4
    GenScript Custom Superior Antibodies Services for CDX4
    Novus Biologicals CDX4 Antibodies
    Abcam antibodies for CDX4
    Cloud-Clone Corp. Antibodies for CDX4 
    Search ThermoFisher Antibodies for CDX4
    LSBio Antibodies in human, mouse, rat for CDX4 

    Assay Products for CDX4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CDX4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CDX4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CDX4 
    Cloud-Clone Corp. CLIAs for CDX4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry O14627

    ProtoNet protein and cluster: O14627

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006820 Caudal-like activation region


    UniProtKB/Swiss-Prot: CDX4_HUMAN, O14627
    Similarity: Belongs to the Caudal homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    CDX4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:
         Genatlas biochemistry entry for CDX4:
    Drosophila caudal family member 4,murine Cdx4 homolog,homeo domain encoding gene

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--
    GO:0043565sequence-specific DNA binding ----
         
    CDX4 for ontologies           About GeneDecksing


    Phenotypes:
         9 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Cdx4):
     cardiovascular system  embryogenesis  growth/size  hematopoietic system  homeostasis/metabolism 
     limbs/digits/tail  mortality/aging  normal  skeleton 

    CDX4 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cdx4tm1.1Jdes for CDX4

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDX4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDX4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDX4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDX4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDX4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CDX4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDX4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CDX4
    Sirion Biotech Customized adenovirus for overexpression of CDX4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDX4 (see all 6)
    OriGene ORF clones in mouse, rat for CDX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDX4 (NM_005193)
    Sino Biological Human cDNA Clone for CDX4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX4
    Sirion Biotech Customized lentivirus for stable overexpression of CDX4 
                         Customized lentivirus expression plasmids for stable overexpression of CDX4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CDX4
    Search LifeMap BioReagents cell lines for CDX4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDX4 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    1 BioSystems Pathway for CDX4
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDX4

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5/6 Interacting proteins for CDX4 (O146273 ENSP000003626134) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HOXA5P207193, ENSP000002227264I2D: score=1 STRING: ENSP00000222726
    ALX4Q9H1613I2D: score=1 
    DLX1P561773I2D: score=1 
    GTF2A1LQ9UNN43I2D: score=1 
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IEA--
    GO:0001568blood vessel development IEA--
    GO:0001890placenta development ----
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent ----

    CDX4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDX4

    Search CenterWatch for drugs/clinical trials and news about CDX4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDX4 gene: 
    NM_005193.1  

    Unigene Cluster for CDX4:

    Caudal type homeobox 4
    Hs.553488
    Unigene Representative Sequence: NM_005193
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000373514(uc011mqk.2)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDX4
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CDX4
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDX4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDX4
    Clone
    Products:
         
    OriGene clones in human, mouse for CDX4 (see all 6)
    OriGene ORF clones in mouse, rat for CDX4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDX4 (NM_005193)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDX4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX4
    Sirion Biotech Customized lentivirus for stable overexpression of CDX4 
                         Customized lentivirus expression plasmids for stable overexpression of CDX4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDX4
    OriGene qSTAR qPCR primer pairs in human, mouse for CDX4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDX4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDX4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDX4

    Additional mRNA sequence: BC128233.1 

    1 DOTS entry:

    DT.91697171 

    1 AceView cDNA sequence:

    NM_005193 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDX4 expression in normal human tissues (normalized intensities)      CDX4 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATGCGCAAG
    CDX4 Expression
    About this image


    CDX4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Primitive Streak Cells Primitive Streak
             Primitive Streak
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord

    See CDX4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDX4

    SOURCE GeneReport for Unigene cluster: Hs.553488
        SABiosciences Custom PCR Arrays for CDX4
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CDX4
    OriGene qSTAR qPCR primer pairs in human, mouse for CDX4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDX4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDX4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDX4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDX4 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdx41 , 5 caudal type homeobox 41, 5 82.27(n)1
    82.98(a)1
      X (46.06 cM)5
    125921  NM_007674.31  NP_031700.11 
     1033213985 
    chicken
    (Gallus gallus)
    Aves CDX41 caudal type homeobox 4 63.82(n)
    59.3(a)
      395320  NM_204614.1  NP_989945.1 
    lizard
    (Anolis carolinensis)
    Reptilia CDX46
    Uncharacterized protein
    76(a)
    1 ↔ 1
    GL343735.1(219441-220529)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdx4-prov2 caudal type homeo box 4 77.23(n)    BC055999.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdx41 caudal type homeo box transcription factor 4 60.38(n)
    57.38(a)
      798281  NM_131109.2  NP_571184.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta cad6
    Abd-B6
    Abdominal B
    20(a)
    11(a)
    possible ortholog
    1 ↔ many
    2L(20770736-20783135)
    3R(12752932-12797958)
    worm
    (Caenorhabditis elegans)
    Secernentea pal-16
    php-36
    (see all 3)
    Protein PHP-3
    (see all 3)
    24(a)
    15(a)
    (see all 3)
    possible ortholog
    many ↔ many
    (see all 3)
    III(4804708-4808711)
    III(12074290-12077556)


    ENSEMBL Gene Tree for CDX4 (if available)
    TreeFam Gene Tree for CDX4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDX4 gene
    CDX12  CDX22  
    2 SIMAP similar genes for CDX4 using alignment to 1 protein entry:     CDX4_HUMAN:
    CDX1    CDX2

    CDX4 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/127 SNPs in CDX4 are shown (see all 127)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr X posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1871980701,2
    --72665542(+) AATTAC/TTTATC 1 -- us2k10--------
    rs1921297631,2
    --72665545(+) TACTTA/TTCAGT 1 -- us2k10--------
    rs1472815651,2
    C--72665586(+) AAGCCA/GGAGGC 1 -- us2k10--------
    rs1827497121,2
    --72665622(+) CATACA/GTAGAA 1 -- us2k10--------
    rs1865748561,2
    --72665672(+) AGTGGC/TCCCAT 1 -- us2k10--------
    rs1902309891,2
    --72665742(+) GTAAGG/TTAGAT 1 -- us2k10--------
    rs1407790941,2
    C--72665783(+) AACCCA/GTGAAA 1 -- us2k10--------
    rs1825730751,2
    --72665848(+) GTGGGG/TGTGCC 1 -- us2k10--------
    rs1869019851,2
    --72665941(+) GCTGGA/GTGGAG 1 -- us2k10--------
    rs1921059841,2
    C--72666157(+) GAGACA/TCCTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CDX4 (72667090 - 72675081 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CDX4: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CDX4
    DNA2.0 Custom Variant and Variant Library Synthesis for CDX4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 300025    OMIM disorders: --

    6 diseases for CDX4:    About MalaCards
    adult acute lymphocytic leukemia    acute lymphocytic leukemia    acute myeloid leukemia    myeloid leukemia
    leukemia    pancreatitis

    1 disease from the University of Copenhagen DISEASES database for CDX4:
    Adult acute lymphocytic leukemia

    CDX4 for disorders           About GeneDecksing


    Export disorders for CDX4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDX4 gene, integrated from 9 sources (see all 19):
    (articles sorted by number of sources associating them with CDX4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. A member of the caudal family of homeobox genes maps to the X-inactivation centre region of the mouse and human X chromosomes. (PubMed id 7655457)1, 3 Horn J.M. and Ashworth A. (1995)
    3. Ectopic expression of CDX4 in human mesenchymal stem c ells does not affect HOX gene expression or induce hematopoietic reprogramming. (PubMed id 22721648)1 Szoke K....Brinchmann J.E. (2012)
    4. b-Catenin activates the HOXA10 and CDX4 genes in myelo id progenitor cells. (PubMed id 23038246)1 Bei L....Eklund E.A. (2012)
    5. HoxA10 activates CDX4 transcription and Cdx4 activate s HOXA10 transcription in myeloid cells. (PubMed id 21471217)1 Bei L....Eklund E. (2011)
    6. [Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (PubMed id 21518475)1 Lu H.Y....Cheng X. (2011)
    7. Hematopoietic development from human induced pluripote nt stem cells. (PubMed id 19796250)1 Lengerke C....Daley G.Q. (2009)
    8. Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. (PubMed id 19371634)1 Yamamichi N....Iba H. (2009)
    9. BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. (PubMed id 18371423)1 Lengerke C....Daley G.Q. (2008)
    10. ParaHox genes in pancreatic cell cultures: effects on the insulin promoter regulation. (PubMed id 18274620)1 Rosanas-Urgell A....Marfany G. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1046 HGNC: 1808 AceView: CDX4 Ensembl:ENSG00000131264 euGenes: HUgn1046
    ECgene: CDX4 H-InvDB: CDX4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDX4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDX4 gene:
    Search GeneIP for patents involving CDX4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CDX4
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     Browse for Gene Knock-down Tools from EMD Millipore
     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Antibodies for CDX4 (CDX4)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for CDX4   OriGene RNAi products in human, mouse, rat for CDX4  
     OriGene qPCR primer pairs and template standards for CDX4   OriGene Protein Over-expression Lysate for CDX4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CDX4  
     OriGene qSTAR qPCR primer pairs in human, mouse for CDX4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CDX4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CDX4   OriGene Custom Protein Services for CDX4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDX4
     QIAGEN SeqTarget long-range PCR primers for resequencing CDX4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDX4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDX4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDX4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDX4
     GenScript Custom Purified and Recombinant Proteins Services for CDX4 GenScript cDNA clones with any tag delivered in your preferred vector for CDX4
     GenScript Custom Assay Services for CDX4 GenScript Custom Superior Antibodies Services for CDX4
     GenScript Custom overexpressing Cell Line Services for CDX4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CDX4 promoter
     Search Chromatin IP Primers for CDX4
     RT2 qPCR Primer Assay in human, mouse, rat CDX4
     GNC Network for CDX4
     SABiosciences Custom PCR Arrays for CDX4
     Search Tocris compounds for CDX4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for CDX4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CDX4 antibodies
     CDX4 proteins
     CDX4 lysates
     Antibodies for CDX4
     See all of Abcam's Antibodies, Kits and Proteins for CDX4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CDX4
     Antibodies for CDX4
     ELISAs for CDX4
     CLIAs for CDX4
     Search LifeMap BioReagents cell lines for CDX4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX4
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CDX4
     Browse SwitchGear Promoter luciferase reporter plasmids for CDX4
     Search ThermoFisher Antibodies for CDX4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CDX4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDX4
    Customized:
     lentivirus for stable overexpression of CDX4
     lentivirus expression plasmids for stable overexpression of CDX4
     adenovirus for overexpression of CDX4
     LSBio Antibodies in human, mouse, rat for CDX4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CDX4 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4