CDX4 Gene
protein-coding GIFtS : 51
GCID: GC0X P072583
caudal type homeobox 4 (Previous name: caudal type homeo box transcription factor 4 )
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Aliasesfor CDX4 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Caudal Type Homeobox 4 1 2 Caudal-Type Homeobox Protein 42 3 Caudal Type Homeo Box Transcription Factor 41 Caudal Type Homeobox Transcription Factor 42 Homeobox Protein CDX-42
Export aliases for CDX4 gene to outside databases Previous GC identifers: GC0XP068480 GC0XP069841 GC0XP070881 GC0XP071533 GC0XP072450 GC0XP066300
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Summariesfor CDX4 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for CDX4 : This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. (provided by RefSeq, Aug 2012)
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Genomic Viewsfor CDX4 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000023.10 NC_018934.1 NT_011669.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CDX4 gene promoter: Sox5 Pax-2b HTF Pax-2 FOXO1a FOXD3 IRF-7A Pax-2a Cdc5 FOXO1 Other transcription factors Search SABiosciences Chromatin IP Primers for CDX4 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CDX4
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: Xq13.2 Ensembl cytogenetic band: Xq13.2 HGNC cytogenetic band: Xq13.2 CDX4 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP072583: view genomic region
(about GC identifiers )
Start:
72,667,088 bp from pter
End:
72,675,081 bp from pter
Size:
7,994 bases
Orientation:
plus strand
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Proteinsfor CDX4 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CDX4_HUMAN, O14627 (See
protein sequence )Recommended Name: Homeobox protein CDX-4 Size : 284 amino acids; 30480 Da
Subcellular location : Nucleus (By similarity)
Secondary accessions : A1A513 Q5JS20Explore the universe of human proteins at neXtProt for CDX4: NX_O14627 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O14627 CDX4 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_005184.1 ENSEMBL proteins: ENSP00000362613 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
CDX4 for ontologies About GeneDecksing CDX4 Antibody Products: Assay Products for CDX4:
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Protein
Domains / Familiesfor CDX4 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CDX4 for domains About GeneDecksing 5/6 InterPro domains/families (see all 6 ):
Graphical View of Domain Structure for InterPro Entry O14627 ProtoNet protein and cluster: O14627
2 Blocks protein families : IPB000047 Lambda and other repressor helix-turn-helix signature IPB006820 Caudal-like activation region UniProtKB/Swiss-Prot: CDX4_HUMAN, O14627 Similarity : Belongs to the Caudal homeobox familySimilarity : Contains 1 homeobox DNA-binding domain
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Functionfor CDX4 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: Genatlas biochemistry entry for CDX4 : Drosophila caudal family member 4,murine Cdx4 homolog,homeo domain encoding gene Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CDX4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CDX4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CDX4 (NM_005193 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDX4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CDX4
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX4
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000976 transcription regulatory region sequence-specific DNA binding
IEA -- GO:0003700 sequence-specific DNA binding transcription factor activity
IEA --
CDX4 for ontologies About GeneDecksing Animal Models: Mouse knock-out Cdx4 tm1.1Jdes for CDX4 9 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Cdx4) :
CDX4 for phenotypes About GeneDecksing
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Pathways & Interactionsfor CDX4 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways   About this table See pathways by source Super-pathway contained gene-specific pathways 1 Regulation of Wnt-mediated beta catenin signaling and target gene transcription
1 BioSystems Pathway for CDX4 Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDX4 STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)5/6 Interacting proteins for CDX4 (O14627 3 ENSP00000362613 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 6 )About this table Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0000122 negative regulation of transcription from RNA polymerase II promoter
IEA -- GO:0001568 blood vessel development
IEA -- GO:0001890 placenta development
-- -- GO:0006351 transcription, DNA-dependent
IEA -- GO:0009952 anterior/posterior pattern specification
IEA --
CDX4 for ontologies About GeneDecksing
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Drugs & Compoundsfor CDX4 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CDX4 Search CenterWatch for drugs/clinical trials and news about CDX4
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Transcriptsfor CDX4 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CDX4 gene: NM_005193.1 Unigene Cluster for CDX4:
Caudal type homeobox 4 Hs.553488 Unigene Representative Sequence: NM_005193 1 Ensembl transcript including schematic representation, and UCSC links where relevant : ENST00000373514 (uc011mqk.2 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CDX4 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CDX4OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: CDX4 (NM_005193 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CDX4 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CDX4
Additional cDNA sequence: BC128233.1
1 DOTS entry : DT.91697171
1 AceView cDNA sequence :
NM_005193 GeneLoc Exon Structure
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Expression for CDX4 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CDX4 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GATGCGCAAG
About this image CDX4 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CDX4 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CDX4 SOURCE GeneReport for Unigene cluster: Hs.553488 SABiosciences Custom PCR Arrays for CDX4 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CDX4Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CDX4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CDX4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CDX4 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX4
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Orthologsfor CDX4 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of animals.
Orthologs for CDX4 gene from 6/22 species (see all 22 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
CDX41
caudal type homeobox 4
63.82(n) 59.3(a)
 
395320 NM_204614.1 NP_989945.1
lizard (Anolis carolinensis)
Reptilia
CDX46
--
78(a)
1 ↔ 1
GL343735.1(219453-220529)
African clawed frog (Xenopus laevis)
Amphibia
cdx4-prov2
caudal type homeo box 4
77.23(n)
 
BC055999.1
zebrafish (Danio rerio)
Actinopterygii
cdx41
caudal type homeo box transcription factor 4
60.38(n) 57.38(a)
 
798281 NM_131109.2 NP_571184.2
fruit fly (Drosophila melanogaster)
Insecta
cad6
caudal
22(a)
1 → many
2L(20770736-20783135)
worm (Caenorhabditis elegans)
Secernentea
pal-16
Homeobox protein pal-1
19(a)
1 → many
III(4804673-4808676)
ENSEMBL Gene Tree for CDX4 (if available)TreeFam Gene Tree for CDX4 (if available)
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Paralogsfor CDX4 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for CDX4 gene CDX1 2 CDX2 2 2 SIMAP similar genes for CDX4 using alignment to 1 protein entry: CDX4_HUMAN :CDX1 CDX2
CDX4 for paralogs About GeneDecksing
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Genomic Variantsfor CDX4 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr X pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CDX4 (72667088 - 72675081 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for CDX4: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CDX4
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Disorders
/ Diseasesfor CDX4 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CDX4 for disorders About GeneDecksing
OMIM gene information: 300025
OMIM disorders : --9 diseases for CDX4 : About MalaCards adult acute lymphocytic leukemia acute lymphocytic leukemia x inactivation lymphocytic leukemia hematopoiesis acute myeloid leukemia myeloid leukemia leukemia pancreatitis 1 disease from the University of Copenhagen DISEASES database for CDX4 :Adult acute lymphocytic leukemia Export disorders for CDX4 gene to outside databases
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Publicationsfor CDX4 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CDX4 gene, integrated from 9 sources (see all 19 ): (articles sorted by number of sources associating them with CDX4) Utopia : connect your pdf to the dynamic world of online information
The DNA sequence of the human X chromosome. (PubMed id 15772651) 1 , 2 Ross M.T.... Bentley D.R. (2005) A member of the caudal family of homeobox genes maps to the X-inactivation centre region of the mouse and human X chromosomes. (PubMed id 7655457) 1 , 3 Horn J.M. and Ashworth A. (1995) Ectopic expression of CDX4 in human mesenchymal stem c ells does not affect HOX gene expression or induce hematopoietic reprogramming. (PubMed id 22721648) 1 Szoke K....Brinchmann J.E. (2012) b-Catenin activates the HOXA10 and CDX4 genes in myelo id progenitor cells. (PubMed id 23038246) 1 Bei L....Eklund E.A. (2012) HoxA10 activates CDX4 transcription and Cdx4 activate s HOXA10 transcription in myeloid cells. (PubMed id 21471217) 1 Bei L....Eklund E. (2011) [Expression and clinical significance of caudal type homeobox transcription factor-2 in adult acute lymphocytic leukemia]. (PubMed id 21518475) 1 Lu H.Y....Cheng X. (2011) Hematopoietic development from human induced pluripote nt stem cells. (PubMed id 19796250) 1 Lengerke C....Daley G.Q. (2009) Cdx2 and the Brm-type SWI/SNF complex cooperatively regulate villin expression in gastrointestinal cells. (PubMed id 19371634) 1 Yamamichi N....Iba H. (2009) BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway. (PubMed id 18371423) 1 Lengerke C....Daley G.Q. (2008) ParaHox genes in pancreatic cell cultures: effects on the insulin promoter regulation. (PubMed id 18274620) 1 Rosanas-Urgell A....Marfany G. (2008)
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External Searches for CDX4 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CDX4 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CDX4 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CDX4 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CDX4 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CDX4 gene: Search GeneIP for patents involving CDX4 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CDX4 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for CDX4 OriGene shRNA RFP for CDX4 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CDX4 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CDX4 OriGene Protein Over-expression Lysate for CDX4 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CDX4 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CDX4 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CDX4 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CDX4 OriGene Custom Protein Services for CDX4 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CDX4 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CDX4 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat CDX4 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CDX4 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CDX4 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CDX4
Search Tocris compounds for CDX4
CDX4 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX4
Search ThermoFisher Antibodies for CDX4
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CDX4
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Aliases for CDX4
Databases for CDX4
Disorders / Diseases for CDX4
Domains / Families for CDX4
Drugs / Compounds for CDX4
Expression for CDX4
Function for CDX4
Genomic Views for CDX4
Intellectual Property for CDX4
Orthologs for CDX4
Paralogs for CDX4
Pathways / Interactions for CDX4
Products for CDX4
Proteins for CDX4
Publications for CDX4
Search Box for CDX4
Summaries for CDX4
Transcripts for CDX4
Variants for CDX4
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