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Aliases for CDX4 Gene

Aliases for CDX4 Gene

  • Caudal Type Homeobox 4 2 3 5
  • Caudal Type Homeo Box Transcription Factor 4 2
  • Caudal-Type Homeobox Protein 4 4

External Ids for CDX4 Gene

Previous GeneCards Identifiers for CDX4 Gene

  • GC0XP068480
  • GC0XP069841
  • GC0XP070881
  • GC0XP071533
  • GC0XP072450
  • GC0XP072583
  • GC0XP066300

Summaries for CDX4 Gene

Entrez Gene Summary for CDX4 Gene

  • This gene encodes a member of a small subfamily of homeobox containing transcription factors. The encoded protein may regulate homeobox gene expression during anteroposterior patterning and hematopoiesis. [provided by RefSeq, Aug 2012]

GeneCards Summary for CDX4 Gene

CDX4 (Caudal Type Homeobox 4) is a Protein Coding gene. Diseases associated with CDX4 include Renpenning Syndrome and Leukemia, Acute Myeloid. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Regulation of Wnt-mediated beta catenin signaling and target gene transcription. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding. An important paralog of this gene is CDX1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDX4 Gene

Genomics for CDX4 Gene

Regulatory Elements for CDX4 Gene

Enhancers for CDX4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CDX4 on UCSC Golden Path with GeneCards custom track

Genomic Location for CDX4 Gene

73,447,254 bp from pter
73,455,245 bp from pter
7,992 bases
Plus strand

Genomic View for CDX4 Gene

Genes around CDX4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDX4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDX4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDX4 Gene

Proteins for CDX4 Gene

  • Protein details for CDX4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Homeobox protein CDX-4
    Protein Accession:
    Secondary Accessions:
    • A1A513
    • Q5JS20

    Protein attributes for CDX4 Gene

    284 amino acids
    Molecular mass:
    30480 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CDX4 Gene

Proteomics data for CDX4 Gene at MOPED

Post-translational modifications for CDX4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CDX4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CDX4 Gene

Domains & Families for CDX4 Gene

Gene Families for CDX4 Gene

Suggested Antigen Peptide Sequences for CDX4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Caudal homeobox family.
  • Contains 1 homeobox DNA-binding domain.
  • Belongs to the Caudal homeobox family.
genes like me logo Genes that share domains with CDX4: view

Function for CDX4 Gene

Molecular function for CDX4 Gene

GENATLAS Biochemistry:
Drosophila caudal family member 4,murine Cdx4 homolog,homeo domain encoding gene
genes like me logo Genes that share phenotypes with CDX4: view

Animal Models for CDX4 Gene

MGI Knock Outs for CDX4:

Animal Model Products

miRNA for CDX4 Gene

miRTarBase miRNAs that target CDX4
Targeted motifs for CDX4 Gene
HOMER Transcription Factor Regulatory Elements motif CDX4
  • Consensus sequence: NGYCATAAAWCH Submotif: canonical Cell Type: ZebrafishEmbryos GEO ID: GSE48254

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology and Transcription Factor Targets for CDX4 Gene

Localization for CDX4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDX4 Gene

Subcellular locations from

Jensen Localization Image for CDX4 Gene COMPARTMENTS Subcellular localization image for CDX4 gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for CDX4 Gene

Pathways & Interactions for CDX4 Gene

genes like me logo Genes that share pathways with CDX4: view

Gene Ontology (GO) - Biological Process for CDX4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0006366 transcription from RNA polymerase II promoter IDA 21471217
GO:0007275 multicellular organism development IEA --
GO:0009887 organ morphogenesis IBA --
GO:0009952 anterior/posterior pattern specification IEA --
genes like me logo Genes that share ontologies with CDX4: view

No data available for SIGNOR curated interactions for CDX4 Gene

Drugs & Compounds for CDX4 Gene

No Compound Related Data Available

Transcripts for CDX4 Gene

mRNA/cDNA for CDX4 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CDX4 Gene

No ASD Table

Relevant External Links for CDX4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CDX4 Gene

mRNA expression in normal human tissues for CDX4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDX4 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x27.8), Skin - Sun Exposed (Lower leg) (x17.8), and Testis (x4.4).

SOURCE GeneReport for Unigene cluster for CDX4 Gene Hs.553488

genes like me logo Genes that share expression patterns with CDX4: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CDX4 Gene

Orthologs for CDX4 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDX4 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CDX4 35
  • 83.57 (n)
  • 86.62 (a)
CDX4 36
  • 83 (a)
(Canis familiaris)
Mammalia CDX4 35
  • 83.04 (n)
  • 79.86 (a)
CDX4 36
  • 78 (a)
(Mus musculus)
Mammalia Cdx4 35
  • 82.39 (n)
  • 82.98 (a)
Cdx4 16
Cdx4 36
  • 82 (a)
(Pan troglodytes)
Mammalia CDX4 35
  • 98.83 (n)
  • 96.81 (a)
CDX4 36
  • 95 (a)
(Rattus norvegicus)
Mammalia Cdx4 35
  • 83.57 (n)
  • 83.8 (a)
(Monodelphis domestica)
Mammalia CDX4 36
  • 44 (a)
(Gallus gallus)
Aves -- 36
  • 47 (a)
  • 53 (a)
(Anolis carolinensis)
Reptilia CDX4 36
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Cdx4 35
African clawed frog
(Xenopus laevis)
Amphibia cdx4-prov 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12139 35
(Danio rerio)
Actinopterygii cdx4 36
  • 44 (a)
(Caenorhabditis elegans)
Secernentea pal-1 36
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
Species with no ortholog for CDX4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDX4 Gene

Gene Tree for CDX4 (if available)
Gene Tree for CDX4 (if available)

Paralogs for CDX4 Gene

Paralogs for CDX4 Gene

(2) SIMAP similar genes for CDX4 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CDX4: view

Variants for CDX4 Gene

Sequence variations from dbSNP and Humsavar for CDX4 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs747681298 -- 73,447,774(+) TCCAA(C/G/T)GCCCA intron-variant
rs747759482 -- 73,448,652(+) TGGGC(C/G)ACTGC intron-variant
rs748037565 -- 73,455,022(+) ATCTA(C/T)CTTTA downstream-variant-500B
rs748215000 -- 73,447,536(+) TGGGC(A/G)CAGTG reference, missense
rs748313062 -- 73,453,598(+) TTGCA(-/ATAGAT)ATATC cds-indel

Variation tolerance for CDX4 Gene

Residual Variation Intolerance Score: 63.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.40; 8.87% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CDX4 Gene

Disorders for CDX4 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDX4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
renpenning syndrome
  • renpenning syndrome 1
leukemia, acute myeloid
  • leukemia, acute myeloid, somatic
- elite association - COSMIC cancer census association via MalaCards
Search CDX4 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CDX4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CDX4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CDX4 Gene

Publications for CDX4 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 67
  2. A member of the caudal family of homeobox genes maps to the X-inactivation centre region of the mouse and human X chromosomes. (PMID: 7655457) Horn J.M. … Ashworth A. (Hum. Mol. Genet. 1995) 2 3
  3. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Ectopic expression of CDX4 in human mesenchymal stem cells does not affect HOX gene expression or induce hematopoietic reprogramming. (PMID: 22721648) SzAPke K. … Brinchmann J.E. (Stem Cell Res 2012) 3

Products for CDX4 Gene

Sources for CDX4 Gene