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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDX1 Gene

protein-coding   GIFtS: 57
GCID: GC05P149526

caudal type homeobox 1

(Previous name: caudal type homeo box transcription factor 1 )
 Explore 26 diseases affiliated with
CDX1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CDX1    

Aliases
for CDX1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Caudal Type Homeobox 11 2
Caudal Type Homeo Box Transcription Factor 11 2
Caudal-Type Homeobox Protein 12 3
Caudal Type Homeobox Transcription Factor 12
Caudal-Type Homeobox Protein CDX12
Homeobox Protein CDX-12

External Ids:    HGNC: 18051   Entrez Gene: 10442   Ensembl: ENSG000001137227   OMIM: 6007465   UniProtKB: P479023   

Export aliases for CDX1 gene to outside databases

Previous GC identifers: GC05P149616 GC05P150133 GC05P149574 GC05P144694


Summaries
for CDX1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CDX1:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein
regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of
the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. (provided
by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
Function: Could play a role in the terminal differentiation of the intestine

Gene Wiki entry for CDX1


Genomic Views
for CDX1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDX1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CDX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

CDX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDX1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149526:  view genomic region     (about GC identifiers)

Start:
 149,546,344 bp from pter      End:
 149,565,107 bp from pter
Size:
 18,764 bases      Orientation:
 plus strand

Proteins
for CDX1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902 (See protein sequence)
Recommended Name: Homeobox protein CDX-1  
Size: 265 amino acids; 28138 Da
Subcellular location: Nucleus
Secondary accessions: Q4VAU4 Q9NYK8
Alternative splicing: 2 isoforms:  P47902-1   P47902-2   

Explore the universe of human proteins at neXtProt for CDX1: NX_P47902

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P47902

    • CDX1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001795.2  
    ENSEMBL proteins: 
     ENSP00000231656  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: CDX1
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    Novus Biologicals CDX1 Protein
    Novus Biologicals CDX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CDX1

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    CDX1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for CDX1

    Protein Domains /
    Families
    for CDX1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CDX1 for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P47902

    ProtoNet protein and cluster: P47902

    2 Blocks protein families:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006820 Caudal-like activation region


    UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
    Similarity: Belongs to the Caudal homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    Function
    for CDX1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
    Function: Could play a role in the terminal differentiation of the intestine

         Genatlas biochemistry entry for CDX1:
    Drosophila caudal family member 1,murine Cdx1 homolog,homeo domain encoding gene,transcriptional regulator of insulin
    gene

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDX1
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CDX1:
    hsa-miR-4283 hsa-miR-4311 hsa-miR-330-5p hsa-miR-637 hsa-miR-2276 hsa-miR-326 hsa-miR-127-5p hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: CDX1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDX1 (see all 4)
    OriGene shRNA RFP: CDX1
    OriGene siRNA: CDX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDX1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CDX1

    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX1 

    Cell Line
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    Search LifeMap BioReagents cell lines for CDX1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX1

    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000976transcription regulatory region sequence-specific DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity IEA--


    CDX1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CDX1:
     Increased cell number in G2M,   Low eccentricity cells 

    Animal Models:
         Mouse knock-outs for CDX1: Cdx1tm1Lhn Cdx1tm1Pgr
         7 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Cdx1):
     craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  hematopoietic system 
     normal  skeleton 

    CDX1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for CDX1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    2Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    		Regulation of Wnt-mediated beta catenin signaling and target gene transcription1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for CDX1
        Cell adhesion Tight junctions


    1 GeneGo (Thomson Reuters) Pathway for CDX1
        Cell adhesion Tight junctions

    1 BioSystems Pathway for CDX1 
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription



    CDX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDX1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/7 Interacting proteins for CDX1 (P479022, 3 ENSP000002316564) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEBPAP497152, 3MINT-6800315 MINT-6800330 MINT-6800304 I2D: score=2 
    LEF1Q9UJU23, ENSP000002651654I2D: score=1 STRING: ENSP00000265165
    ALX4Q9H1613I2D: score=1 
    DLX1P561773I2D: score=1 
    GTF2E1P290833I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007389pattern specification process ----
    GO:0009887organ morphogenesis TAS8530027
    GO:0009952anterior/posterior pattern specification IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IEA--
    GO:0060349bone morphogenesis IEA--


    CDX1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for CDX1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDX1
    3 Novoseek chemical compound relationships for CDX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    crcs 46.7 2 14704280 (1), 16596323 (1)
    5-aza-2'deoxycytidine 32.8 3 12124393 (2), 14704280 (1)
    retinoic acid 20.4 4 15143193 (1), 10938132 (1), 7644503 (1)

    Search CenterWatch for drugs/clinical trials and news about CDX1 

    Transcripts
    for CDX1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CDX1 gene: 
    NM_001804.2  

    Unigene Cluster for CDX1:

    Caudal type homeobox 1
    Hs.1545  [show with all ESTs]
    Unigene Representative Sequence: NM_001804
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000231656(uc003lrq.3)

    miRNA
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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CDX1:
    hsa-miR-4283 hsa-miR-4311 hsa-miR-330-5p hsa-miR-637 hsa-miR-2276 hsa-miR-326 hsa-miR-127-5p hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmid: CDX1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDX1 (see all 4)
    OriGene shRNA RFP: CDX1
    OriGene siRNA: CDX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDX1
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CDX1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CDX1 (NM_001804)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX1 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDX1

    Additional cDNA sequence: 

    AF239666.1 BC096249.1 BC096250.1 BC096251.1 BC096252.1 BC127121.1 BC127122.1 U15212.1 
    U51095.1 

    5 DOTS entries:

    DT.110836  DT.97799174  DT.120810274  DT.120810277  DT.120810278 

    19 AceView cDNA sequences:

    BM789423 BM823903 BM797713 AF239666 BF510316 BM826225 AA308610 BM793162 
    U51095 NM_001804 BM852896 BM791953 BQ083083 U15212 BM853012 T24589 
    BM795963 BM793967 BM826857 

    GeneLoc Exon Structure


    Expression
    for CDX1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDX1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CDX1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Gut TubeHindgutHindgut Endoderm CellsEndoderm
    LimbLimb BudLimb
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See CDX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDX1

    SOURCE GeneReport for Unigene cluster: Hs.1545

    UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
    Tissue specificity: Intestinal epithelium

        SABiosciences Expression via Pathway-Focused PCR Array including CDX1: 
              Homeobox (HOX) Genes in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for CDX1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CDX1 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cdx11 , 5 caudal type homeobox 11, 5 84.28(n)1
    85.66(a)1    		   18 (34.41 cM)5
    125901  NM_009880.31  NP_034010.31 
     610188625 
    chicken
    (Gallus gallus)    		 Aves CDX11 caudal type homeobox 1 68.82(n)
    62.9(a)    		   395397  NM_204676.2  NP_990007.2 
    lizard
    (Anolis carolinensis)    		 Reptilia CDX16
    		 --
    		 69(a)
    		 1 ↔ 1
    		 2(139362965-139410429)
    zebrafish
    (Danio rerio)    		 Actinopterygii cdx1b1 caudal type homeobox 1 b 63.11(n)
    59.84(a)    		   100004956  NM_001098762.1  NP_001092232.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta cad6
    		 caudal
    		 20(a)
    		 1 → many
    		 2L(20770736-20783135)
    worm
    (Caenorhabditis elegans)    		 Secernentea pal-16
    		 Homeobox protein pal-1
    		 20(a)
    		 1 → many
    		 III(4804673-4808676)


    ENSEMBL Gene Tree for CDX1 (if available)
    TreeFam Gene Tree for CDX1 (if available) 

    Paralogs
    for CDX1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDX1 gene
    CDX42  CDX22  
    18/19 SIMAP similar genes for CDX1 using alignment to 4 protein entries:     CDX1_HUMAN (see all proteins) (see all similar genes):
    HOXD11    HOXC13    HOX B6    HMX2    HOXB8    CDX4
    HOXA10    HOXB1    DRGX    NKX2-5    CDX2    HLX
    MSX1    DLX6    MEOX1    LMX1B    LHX2    NKX2-6

    CDX1 for paralogs           About GeneDecksing



    Genomic Variants
    for CDX1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/313 NCBI SNPs in CDX1 are shown (see all 313)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1838426551,2
    		--149544366(+) CCATGC/TGCTCA 1 -- us2k10--------
    rs1452933021,2
    		--149544367(+) CATGTA/GCTCAT 1 -- us2k10--------
    rs1890587681,2
    		--149544440(+) GCTCCA/GCCCGG 1 -- us2k10--------
    rs1926442401,2
    		--149544540(+) CCTCAA/TTGCTT 1 -- us2k10--------
    rs1432704051,2
    		--149544715(+) TGGAAA/GGGCCC 1 -- us2k10--------
    rs37563151,2
    		C,F,H,--149544722(+) GCCCCA/GGGCTC 1 -- us2k113Minor allele frequency- G:0.34NS EA NA WA 756
    rs765825761,2
    		C,F,--149544729(+) GCTCAG/CGTGAA 1 -- us2k15Minor allele frequency- C:0.13NA WA CSA 243
    rs1856843741,2
    		--149544807(+) GCTCCC/TGGCCC 1 -- us2k10--------
    rs1905945371,2
    		--149544954(+) CACATC/TCCTGC 1 -- us2k10--------
    rs68722711,2
    		C,F,A,H,--149545043(+) TTGTGA/C/GGGAGG 1 -- us2k112NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for CDX1 (149546344 - 149565107 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CDX1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CDX1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDX1

    Disorders / Diseases
    for CDX1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CDX1 for disorders           About GeneDecksing

    OMIM gene information: 600746    OMIM disorders: --

    20/26 diseases for CDX1 (see all 26):    About MalaCards
    treacher collins syndrome    adult acute lymphocytic leukemia    bile reflux    acute lymphocytic leukemia
    barrett's esophagus    esophageal squamous cell carcinoma    lymphocytic leukemia    squamous cell carcinoma
    acute lymphoblastic leukemia    lymphoblastic leukemia    acute myeloid leukemia    myeloid leukemia
    hirschsprung's disease    leukemia    colon cancer    gastric cancer
    adenocarcinoma    colorectal cancer    carcinoma    esophagitis

    1 disease from the University of Copenhagen DISEASES database for CDX1:
    Bile reflux

    10/17 Novoseek disease relationships for CDX1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metaplasia 72.1 41 19725873 (8), 11871772 (5), 10666391 (4), 15361487 (4) (see all 13)
    colon cancer 57.7 19 15215241 (6), 18187048 (3), 14508520 (3), 19900445 (1) (see all 9)
    colorectal carcinoma 47.4 10 15378566 (3), 14704280 (2), 19188603 (2), 9593754 (1)
    colorectal cancer 44.8 22 16491830 (6), 12124393 (5), 12970739 (2), 10833444 (1) (see all 8)
    adenocarcinoma 43.5 12 9247467 (3), 15910596 (2), 15774774 (1), 19106744 (1) (see all 8)
    gastric cancer 38.3 4 14615935 (2), 18775915 (2)
    colon carcinoma 35.9 4 9593754 (1), 12970739 (1), 15378566 (1)
    colon adenocarcinoma 31.1 2 12270138 (1), 9396760 (1)
    cancer 27.1 10 9126347 (1), 16491830 (1), 19188603 (1), 12855703 (1) (see all 8)
    gastric carcinoma 25.9 5 11790453 (1), 19725873 (1), 14525978 (1)


    Export disorders for CDX1 gene to outside databases

    Publications
    for CDX1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDX1 gene, integrated from 9 sources (see all 99):
    (articles sorted by number of sources associating them with CDX1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. (PubMed id 8530027)1, 2, 3, 9 Bonner C.A.... Wasmuth J.J. (1995)
    2. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. (PubMed id 9036867)1, 2, 9 Mallo G.V.... Iovanna J.L. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. (PubMed id 14704280)1, 9 Wong N.A....Bodmer W.F. (2004)
    5. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. (PubMed id 15143193)1, 9 Beland M....Lohnes D. (2004)
    6. DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. (PubMed id 12124393)1, 9 Suh E.R....Traber P.G. (2002)
    7. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. (PubMed id 19188603)1, 9 Chan C.W....Bodmer W.F. (2009)
    8. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. (PubMed id 15774940)1, 9 Alkhoury F....Hodin R.A. (2005)
    9. Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. (PubMed id 14715525)1, 9 Rankin E.B....Suh E. (2004)
    10. Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. (PubMed id 18187048)1, 9 Lu X....Namour F. (2008)

    External Searches for CDX1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing CDX1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1044 HGNC: 1805 AceView: CDX1 Ensembl:ENSG00000113722 euGenes: HUgn1044
    ECgene: CDX1 H-InvDB: CDX1

    Other Databases showing CDX1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing CDX1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDX1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CDX1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CDX1 gene:
    Search GeneIP for patents involving CDX1

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