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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CDX1 Gene

protein-coding   GIFtS: 59
GCID: GC05P149526

Caudal Type Homeobox 1

(Previous name: caudal type homeo box transcription factor 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Caudal Type Homeobox 11 2
Caudal Type Homeo Box Transcription Factor 11 2
Caudal-Type Homeobox Protein 12 3
Caudal Type Homeobox Transcription Factor 12
Caudal-Type Homeobox Protein CDX12
Homeobox Protein CDX-12

External Ids:    HGNC: 18051   Entrez Gene: 10442   Ensembl: ENSG000001137227   OMIM: 6007465   UniProtKB: P479023   

Export aliases for CDX1 gene to outside databases

Previous GC identifers: GC05P149616 GC05P150133 GC05P149574 GC05P144694


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDX1 Gene:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding
protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce
expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional
activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDX1 Gene: 
CDX1 (caudal type homeobox 1) is a protein-coding gene. Diseases associated with CDX1 include bile reflux, and treacher collins syndrome, and among its related super-pathways are Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases. GO annotations related to this gene include transcription regulatory region sequence-specific DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is CDX4.

UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
Function: Could play a role in the terminal differentiation of the intestine

Gene Wiki entry for CDX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_029289.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CDX1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDX1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CDX1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

CDX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDX1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149526:  view genomic region     (about GC identifiers)

Start:
149,546,344 bp from pter      End:
149,564,121 bp from pter
Size:
17,778 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902 (See protein sequence)
Recommended Name: Homeobox protein CDX-1  
Size: 265 amino acids; 28138 Da
Subcellular location: Nucleus
Secondary accessions: Q4VAU4 Q9NYK8
Alternative splicing: 2 isoforms:  P47902-1   P47902-2   

Explore the universe of human proteins at neXtProt for CDX1: NX_P47902

Explore proteomics data for CDX1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P47902

  • CDX1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CDX1 Protein Expression
    REFSEQ proteins: NP_001795.2  
    ENSEMBL proteins: 
     ENSP00000231656  

    Human Recombinant Protein Products for CDX1: 
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    OriGene Protein Over-expression Lysate for CDX1
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CDX1
    GenScript Custom Purified and Recombinant Proteins Services for CDX1
    Novus Biologicals CDX1 Protein
    Novus Biologicals CDX1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CDX1 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--

    CDX1 for ontologies           About GeneDecksing



    CDX1 Antibody Products: 
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    Cloud-Clone Corp. ELISAs for CDX1 
    Cloud-Clone Corp. CLIAs for CDX1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    HOXL: Homeoboxes / ANTP class : HOXL subclass

    5/6 InterPro protein domains (see all 6):
     IPR020479 Homeobox_metazoa
     IPR000047 HTH_motif
     IPR017970 Homeobox_CS
     IPR001356 Homeodomain
     IPR009057 Homeodomain-like

    Graphical View of Domain Structure for InterPro Entry P47902

    ProtoNet protein and cluster: P47902

    2 Blocks protein domains:
    IPB000047 Lambda and other repressor helix-turn-helix signature
    IPB006820 Caudal-like activation region


    UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
    Similarity: Belongs to the Caudal homeobox family
    Similarity: Contains 1 homeobox DNA-binding domain


    CDX1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDX1_HUMAN, P47902
    Function: Could play a role in the terminal differentiation of the intestine

         Genatlas biochemistry entry for CDX1:
    Drosophila caudal family member 1,murine Cdx1 homolog,homeo domain encoding gene,transcriptional regulator of
    insulin gene

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IDA15774940
    GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA15774940
    GO:0003677DNA binding ----
    GO:0003700sequence-specific DNA binding transcription factor activity ----
    GO:0005515protein binding IPI19059241
         
    CDX1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDX1:
     Increased cell number in G2M,   Low eccentricity cells 

         7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cdx1):
     craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  hematopoietic system 
     normal  skeleton 

    CDX1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CDX1: Cdx1tm1Lhn Cdx1tm1Pgr

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CDX1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CDX1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDX1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDX1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDX1
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CDX1:
    hsa-miR-4283 hsa-miR-4311 hsa-miR-330-5p hsa-miR-637 hsa-miR-2276 hsa-miR-326 hsa-miR-127-5p hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidCDX1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDX1
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    Gene Editing
    Products:
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    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CDX1 (see all 6)
    OriGene ORF clones in mouse, rat for CDX1
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    GenScript: all cDNA clones in your preferred vector: CDX1 (NM_001804)
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                         Customized lentivirus expression plasmids for stable overexpression of CDX1 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CDX1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    2Regulation of Wnt-mediated beta catenin signaling and target gene transcription
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CDX1
        Cell adhesion Tight junctions


    1 GeneGo (Thomson Reuters) Pathway for CDX1
        Cell adhesion Tight junctions

    1 BioSystems Pathway for CDX1
        Regulation of Wnt-mediated beta catenin signaling and target gene transcription



    CDX1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CDX1

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/7 Interacting proteins for CDX1 (P479022, 3 ENSP000002316564) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEBPAP497152, 3MINT-6800315 MINT-6800330 MINT-6800304 I2D: score=2 
    LEF1Q9UJU23, ENSP000002651654I2D: score=1 STRING: ENSP00000265165
    ALX4Q9H1613I2D: score=1 
    DLX1P561773I2D: score=1 
    GTF2E1P290833I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007275multicellular organismal development ----
    GO:0007389pattern specification process ----
    GO:0009887organ morphogenesis TAS8530027
    GO:0009952anterior/posterior pattern specification IEA--

    CDX1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CDX1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CDX1

    3 Novoseek inferred chemical compound relationships for CDX1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    crcs 46.7 2 14704280 (1), 16596323 (1)
    5-aza-2'deoxycytidine 32.8 3 12124393 (2), 14704280 (1)
    retinoic acid 20.4 4 15143193 (1), 10938132 (1), 7644503 (1)

    Search CenterWatch for drugs/clinical trials and news about CDX1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CDX1 gene: 
    NM_001804.2  

    Unigene Cluster for CDX1:

    Caudal type homeobox 1
    Hs.1545  [show with all ESTs]
    Unigene Representative Sequence: NM_001804
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000231656(uc003lrq.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CDX1
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CDX1:
    hsa-miR-4283 hsa-miR-4311 hsa-miR-330-5p hsa-miR-637 hsa-miR-2276 hsa-miR-326 hsa-miR-127-5p hsa-miR-155
    SwitchGear 3'UTR luciferase reporter plasmidCDX1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CDX1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CDX1
    Clone
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    OriGene clones in human, mouse for CDX1 (see all 6)
    OriGene ORF clones in mouse, rat for CDX1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CDX1 (NM_001804)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDX1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX1
    Sirion Biotech Customized lentivirus for stable overexpression of CDX1 
                         Customized lentivirus expression plasmids for stable overexpression of CDX1 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CDX1
    OriGene qSTAR qPCR primer pairs in human, mouse for CDX1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CDX1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CDX1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDX1

    Additional mRNA sequence: 

    AF239666.1 BC096249.1 BC096250.1 BC096251.1 BC096252.1 BC127121.1 BC127122.1 U15212.1 
    U51095.1 

    5 DOTS entries:

    DT.110836  DT.97799174  DT.120810274  DT.120810277  DT.120810278 

    19 AceView cDNA sequences:

    BM789423 AF239666 BF510316 BM797713 BM823903 U51095 U15212 BM852896 
    BM826225 AA308610 BQ083083 BM793162 BM791953 NM_001804 BM853012 T24589 
    BM795963 BM793967 BM826857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CDX1 expression in normal human tissues (normalized intensities)      CDX1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CDX1 Expression
    About this image


    CDX1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand (Gastrointestinal Tract)
     
     Colon (Gastrointestinal Tract)    fully expand to see all 2 entries
             rectum ; glandular cells   
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Gut Tube (Gastrointestinal Tract)
             Hindgut Endoderm Cells Hindgut
             appendix ; glandular cells   

    See CDX1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CDX1

    SOURCE GeneReport for Unigene cluster: Hs.1545

    UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
    Tissue specificity: Intestinal epithelium

        SABiosciences Expression via Pathway-Focused PCR Array including CDX1: 
              Homeobox (HOX) Genes in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CDX1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CDX1 gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdx11 , 5 caudal type homeobox 11, 5 84.28(n)1
    85.66(a)1
      18 (34.41 cM)5
    125901  NM_009880.31  NP_034010.31 
     610188625 
    chicken
    (Gallus gallus)
    Aves CDX11 caudal type homeobox 1 68.82(n)
    62.9(a)
      395397  NM_204676.2  NP_990007.2 
    lizard
    (Anolis carolinensis)
    Reptilia CDX16
    Uncharacterized protein
    65(a)
    1 ↔ 1
    2(139361214-139410429)
    zebrafish
    (Danio rerio)
    Actinopterygii cdx1b1 caudal type homeobox 1 b 63.11(n)
    59.84(a)
      100004956  NM_001098762.1  NP_001092232.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta cad6
    Abd-B6
    Abdominal B
    20(a)
    11(a)
    possible ortholog
    many → 1
    2L(20770736-20783135)
    3R(12752932-12797958)
    worm
    (Caenorhabditis elegans)
    Secernentea pal-16
    php-36
    (see all 3)
    Protein PHP-3
    (see all 3)
    25(a)
    16(a)
    (see all 3)
    possible ortholog
    many ↔ many
    (see all 3)
    III(4804708-4808711)
    III(12074290-12077556)


    ENSEMBL Gene Tree for CDX1 (if available)
    TreeFam Gene Tree for CDX1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CDX1 gene
    CDX42  CDX22  
    18 SIMAP similar genes for CDX1 using alignment to 4 protein entries:     CDX1_HUMAN (see all proteins):
    HOXD11    HOXC13    HOX B6    HMX2    HOXB8    CDX4
    HOXA10    HOXB1    DRGX    NKX2-5    CDX2    DLX6
    HLX    MSX1    LMX1B    LHX2    NKX2-6    ISL1

    CDX1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/371 SNPs in CDX1 are shown (see all 371)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838426551,2
    --149544366(+) CCATGC/TGCTCA 1 -- us2k10--------
    rs1452933021,2
    --149544367(+) CATGTA/GCTCAT 1 -- us2k10--------
    rs1890587681,2
    --149544440(+) GCTCCA/GCCCGG 1 -- us2k10--------
    rs1926442401,2
    --149544540(+) CCTCAA/TTGCTT 1 -- us2k10--------
    rs1432704051,2
    C--149544715(+) TGGAAA/GGGCCC 1 -- us2k10--------
    rs37563151,2
    C,F,H--149544722(+) GCCCCA/GGGCTC 1 -- us2k113Minor allele frequency- G:0.34NS EA NA WA 756
    rs765825761,2
    C,F--149544729(+) GCTCAG/CGTGAA 1 -- us2k15Minor allele frequency- C:0.13NA WA CSA 243
    rs1856843741,2
    --149544807(+) GCTCCC/TGGCCC 1 -- us2k10--------
    rs1905945371,2
    --149544954(+) CACATC/TCCTGC 1 -- us2k10--------
    rs68722711,2
    C,F,A,H--149545043(+) TTGTGA/C/GGGAGG 1 -- us2k112NA WA CSA EA 374

    HapMap Linkage Disequilibrium report for CDX1 (149546344 - 149564121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CDX1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv883027CNV Loss21882294
    nsv883030CNV Loss21882294


    Human Gene Mutation Database (HGMD): CDX1
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600746    OMIM disorders: --

    20/26 diseases for CDX1 (see all 26):    About MalaCards
    bile reflux    treacher collins syndrome    adult acute lymphocytic leukemia    acute lymphocytic leukemia
    gastric adenocarcinoma    barrett's esophagus    hirschsprung's disease    colon cancer
    esophageal squamous cell carcinoma    gastric cancer    duodenitis    esophagitis
    colon adenocarcinoma    colorectal cancer    acute lymphoblastic leukemia    acute myeloid leukemia
    lymphoblastic leukemia    adenocarcinoma    myeloid leukemia    cholangiocarcinoma

    1 disease from the University of Copenhagen DISEASES database for CDX1:
    Bile reflux

    CDX1 for disorders           About GeneDecksing

    10/17 Novoseek inferred disease relationships for CDX1 gene (see all 17)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    metaplasia 72.1 41 19725873 (8), 11871772 (5), 10666391 (4), 15361487 (4) (see all 13)
    colon cancer 57.7 19 15215241 (6), 18187048 (3), 14508520 (3), 19900445 (1) (see all 9)
    colorectal carcinoma 47.4 10 15378566 (3), 14704280 (2), 19188603 (2), 9593754 (1)
    colorectal cancer 44.8 22 16491830 (6), 12124393 (5), 12970739 (2), 10833444 (1) (see all 8)
    adenocarcinoma 43.5 12 9247467 (3), 15910596 (2), 15774774 (1), 19106744 (1) (see all 8)
    gastric cancer 38.3 4 14615935 (2), 18775915 (2)
    colon carcinoma 35.9 4 9593754 (1), 12970739 (1), 15378566 (1)
    colon adenocarcinoma 31.1 2 12270138 (1), 9396760 (1)
    cancer 27.1 10 9126347 (1), 16491830 (1), 19188603 (1), 12855703 (1) (see all 8)
    gastric carcinoma 25.9 5 11790453 (1), 19725873 (1), 14525978 (1)


    Export disorders for CDX1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CDX1 gene, integrated from 9 sources (see all 105):
    (articles sorted by number of sources associating them with CDX1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. (PubMed id 8530027)1, 2, 3, 9 Bonner C.A.... Wasmuth J.J. (1995)
    2. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. (PubMed id 9036867)1, 2, 9 Mallo G.V.... Iovanna J.L. (1997)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. (PubMed id 14704280)1, 9 Wong N.A....Bodmer W.F. (2004)
    5. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. (PubMed id 15143193)1, 9 Beland M....Lohnes D. (2004)
    6. DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. (PubMed id 12124393)1, 9 Suh E.R....Traber P.G. (2002)
    7. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. (PubMed id 19188603)1, 9 Chan C.W....Bodmer W.F. (2009)
    8. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. (PubMed id 15774940)1, 9 Alkhoury F....Hodin R.A. (2005)
    9. Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. (PubMed id 14715525)1, 9 Rankin E.B....Suh E. (2004)
    10. Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. (PubMed id 18187048)1, 9 Lu X....Namour F. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1044 HGNC: 1805 AceView: CDX1 Ensembl:ENSG00000113722 euGenes: HUgn1044
    ECgene: CDX1 H-InvDB: CDX1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CDX1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CDX1 gene:
    Search GeneIP for patents involving CDX1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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