Aliases for CDX1 Gene
External Ids for CDX1 Gene
Previous GeneCards Identifiers for CDX1 Gene
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]
GeneCards Summary for CDX1 Gene
CDX1 (Caudal Type Homeobox 1) is a Protein Coding gene. Diseases associated with CDX1 include colon adenocarcinoma and bile reflux. Among its related pathways are Regulation of Wnt-mediated beta catenin signaling and target gene transcription and Cell adhesion Integrin-mediated cell adhesion and migration. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is CDX4.
UniProtKB/Swiss-Prot for CDX1 Gene
Could play a role in the terminal differentiation of the intestine