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CDX1 Gene

protein-coding   GIFtS: 56
GCID: GC05P149526

Caudal Type Homeobox 1

(Previous name: caudal type homeo box transcription factor 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Caudal Type Homeobox 11 2
Caudal Type Homeo Box Transcription Factor 11 2
Caudal-Type Homeobox Protein 12 3
Caudal Type Homeobox Transcription Factor 12
Caudal-Type Homeobox Protein CDX12
Homeobox Protein CDX-12

External Ids:    HGNC: 18051   Entrez Gene: 10442   Ensembl: ENSG000001137227   OMIM: 6007465   UniProtKB: P479023   

Export aliases for CDX1 gene to outside databases

Previous GC identifers: GC05P149616 GC05P150133 GC05P149574 GC05P144694


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDX1 Gene:
This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding
protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce
expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional
activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for CDX1 Gene:
CDX1 (caudal type homeobox 1) is a protein-coding gene. Diseases associated with CDX1 include bile reflux, and adult acute lymphocytic leukemia. GO annotations related to this gene include RNA polymerase II distal enhancer sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription. An important paralog of this gene is CDX4.

UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
Function: Could play a role in the terminal differentiation of the intestine

Gene Wiki entry for CDX1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NC_018916.2  NT_029289.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDX1 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCDX1 promoter sequence
   Search Chromatin IP Primers for CDX1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDX1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q32   Ensembl cytogenetic band:  5q32   HGNC cytogenetic band: 5q32

CDX1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDX1 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P149526:  view genomic region     (about GC identifiers)

Start:
149,546,344 bp from pter      End:
149,564,121 bp from pter
Size:
17,778 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902 (See protein sequence)
Recommended Name: Homeobox protein CDX-1  
Size: 265 amino acids; 28138 Da
Secondary accessions: Q4VAU4 Q9NYK8
Alternative splicing: 2 isoforms:  P47902-1   P47902-2   

Explore the universe of human proteins at neXtProt for CDX1: NX_P47902

Explore proteomics data for CDX1 at MOPED


See CDX1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001795.2  
ENSEMBL proteins: 
 ENSP00000231656  

CDX1 Human Recombinant Protein Products:

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Cloud-Clone Corp. Proteins for CDX1

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CDX1 Assay Products:

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Cloud-Clone Corp. ELISAs for CDX1
Cloud-Clone Corp. CLIAs for CDX1


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
HOXL: Homeoboxes / ANTP class : HOXL subclass

Selected InterPro protein domains (see all 6):
 IPR020479 Homeobox_metazoa
 IPR000047 HTH_motif
 IPR017970 Homeobox_CS
 IPR001356 Homeobox_dom
 IPR009057 Homeodomain-like

Graphical View of Domain Structure for InterPro Entry P47902

ProtoNet protein and cluster: P47902

2 Blocks protein domains:
IPB000047 Lambda and other repressor helix-turn-helix signature
IPB006820 Caudal-like activation region


UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
Similarity: Belongs to the Caudal homeobox family
Similarity: Contains 1 homeobox DNA-binding domain


CDX1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: CDX1_HUMAN, P47902
Function: Could play a role in the terminal differentiation of the intestine

     Genatlas biochemistry entry for CDX1:
Drosophila caudal family member 1,murine Cdx1 homolog,homeo domain encoding gene,transcriptional regulator of
insulin gene

     Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding IDA15774940
GO:0001205RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IDA15774940
GO:0003677DNA binding ----
GO:0003700sequence-specific DNA binding transcription factor activity ----
GO:0005515protein binding IPI19059241
     
CDX1 for ontologies           About GeneDecksing


Phenotypes:
     2 GenomeRNAi human phenotypes for CDX1:
 Increased cell number in G2M,   Low eccentricity cells 

     7 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cdx1):
 craniofacial  digestive/alimentary  embryogenesis  endocrine/exocrine gland  hematopoietic system 
 normal  skeleton 

CDX1 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for CDX1: Cdx1tm1Lhn Cdx1tm1Pgr

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDX1
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CDX1

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDX1
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDX1

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat CDX1 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate CDX1:
hsa-miR-4283 hsa-miR-4311 hsa-miR-330-5p hsa-miR-637 hsa-miR-2276 hsa-miR-326 hsa-miR-127-5p hsa-miR-155
SwitchGear 3'UTR luciferase reporter plasmidCDX1 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for CDX1
Predesigned siRNA for gene silencing in human, mouse, rat CDX1

Gene Editing
Products:
DNA2.0 Custom Protein Engineering Service for CDX1

Clone
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OriGene clones in human, mouse for CDX1 (see all 5)
OriGene ORF clones in mouse, rat for CDX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CDX1 (NM_001804)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX1

Cell Line
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GenScript Custom overexpressing Cell Line Services for CDX1
Browse ESI BIO Cell Lines and PureStem Progenitors for CDX1 
In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX1


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CDX1_HUMAN, P47902: Nucleus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus5

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

CDX1 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for CDX1 About    
See pathways by source

SuperPathContained pathways About
1Cell adhesion Integrin mediated cell adhesion and migration
Cell adhesion Tight junctions0.33
2Regulation of Wnt-mediated beta catenin signaling and target gene transcription
Regulation of Wnt-mediated beta catenin signaling and target gene transcription

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways


1 GeneGo (Thomson Reuters) Pathway for CDX1
    Cell adhesion Tight junctions

1 BioSystems Pathway for CDX1
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription


    Pathway & Disease-focused RT2 Profiler PCR Array including CDX1: 
          Homeobox (HOX) Genes in human mouse rat

Interactions:

    GeneGlobe Interaction Network for CDX1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for CDX1 (P479021, 2, 3 ENSP000002316564) via UniProtKB, MINT, STRING, and/or I2D (see all 43)
InteractantInteraction Details
GeneCardExternal ID(s)
CEBPAP497151, 2, 3EBI-8514176,EBI-1172054 MINT-6800315 MINT-6800330 MINT-6800304 I2D: score=2 
ALX4Q9H1613, ENSP000003327444I2D: score=1 STRING: ENSP00000332744
LEF1Q9UJU23, ENSP000002651654I2D: score=1 STRING: ENSP00000265165
NKX2-3Q8TAU03, ENSP000003428284I2D: score=1 STRING: ENSP00000342828
DLX1P561773I2D: score=1 
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Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006355regulation of transcription, DNA-templated ----
GO:0007275multicellular organismal development ----
GO:0007389pattern specification process ----
GO:0009887organ morphogenesis TAS8530027
GO:0009952anterior/posterior pattern specification IEA--

CDX1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for CDX1

3 Novoseek inferred chemical compound relationships for CDX1 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
crcs 46.7 2 14704280 (1), 16596323 (1)
5-aza-2'deoxycytidine 32.8 3 12124393 (2), 14704280 (1)
retinoic acid 20.4 4 15143193 (1), 10938132 (1), 7644503 (1)



CDX1 for compounds           About GeneDecksing



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for CDX1 gene: 
NM_001804.2  

Unigene Cluster for CDX1:

Caudal type homeobox 1
Hs.1545  [show with all ESTs]
Unigene Representative Sequence: NM_001804
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000231656(uc003lrq.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat CDX1 using miScript Target Protectors
8 qRT-PCR Assays for microRNAs that regulate CDX1:
hsa-miR-4283 hsa-miR-4311 hsa-miR-330-5p hsa-miR-637 hsa-miR-2276 hsa-miR-326 hsa-miR-127-5p hsa-miR-155
SwitchGear 3'UTR luciferase reporter plasmidCDX1 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for CDX1
Predesigned siRNA for gene silencing in human, mouse, rat CDX1
Clone
Products:
     
OriGene clones in human, mouse for CDX1 (see all 5)
OriGene ORF clones in mouse, rat for CDX1
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: CDX1 (NM_001804)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for CDX1
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDX1
Primer
Products:
    
OriGene qPCR primer pairs and template standards for CDX1
OriGene qSTAR qPCR primer pairs in human, mouse for CDX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDX1
  QuantiTect SYBR Green Assays in human, mouse, rat CDX1
  QuantiFast Probe-based Assays in human, mouse, rat CDX1

Additional mRNA sequence: 

AF239666.1 BC096249.1 BC096250.1 BC096251.1 BC096252.1 BC127121.1 BC127122.1 U15212.1 
U51095.1 

5 DOTS entries:

DT.110836  DT.97799174  DT.120810274  DT.120810277  DT.120810278 

19 AceView cDNA sequences:

BM797713 BM823903 BM789423 AF239666 BF510316 BM791953 BM852896 AA308610 
BM793162 U15212 BM826225 U51095 NM_001804 BQ083083 T24589 BM853012 
BM795963 BM793967 BM826857 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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CDX1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
CDX1 Expression
About this image


CDX1 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 6) fully expand
 
 Hypoblast (Extraembryonic Tissues)
         Hypoblast Cells Hypoblast
 
 Ectoderm (Gastrulation Derivatives)
         Intraembryonic Ectoderm Cells Ectoderm
 
 Neural Ectoderm (Nervous System)
         Neural ectoderm cells
 
 Mesoderm (Gastrulation Derivatives)
         Mesoderm Cells Mesoderm
 
 Endoderm (Gastrulation Derivatives)
         Definitive Endoderm Cells Definitive Endoderm
CDX1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

CDX1 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.1545

UniProtKB/Swiss-Prot: CDX1_HUMAN, P47902
Tissue specificity: Intestinal epithelium

    Pathway & Disease-focused RT2 Profiler PCR Array including CDX1: 
          Homeobox (HOX) Genes in human mouse rat

Primer
Products:
OriGene qPCR primer pairs and template standards for CDX1
OriGene qSTAR qPCR primer pairs in human, mouse for CDX1
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CDX1
QuantiTect SYBR Green Assays in human, mouse, rat CDX1
QuantiFast Probe-based Assays in human, mouse, rat CDX1
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDX1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for CDX1 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Cdx11 , 5 caudal type homeobox 11, 5 84.65(n)1
85.66(a)1
  18 (34.41 cM)5
125901  NM_009880.31  NP_034010.31 
 610188625 
chicken
(Gallus gallus)
Aves CDX16
Gallus gallus caudal type homeobox 1 (CDX1), mRNA....
52(a)
1 ↔ 1
13(12551722-12561961)
lizard
(Anolis carolinensis)
Reptilia CDX16
caudal type homeobox 1
67(a)
1 ↔ 1
2(139361214-139410429)
zebrafish
(Danio rerio)
Actinopterygii cdx1b6
caudal type homeobox 1 b
51(a)
1 ↔ 1
21(42527977-42543419) ENSDARG00000058999
fruit fly
(Drosophila melanogaster)
Insecta cad6
caudal
21(a)
1 ↔ 1
2L(20770736-20783135)
worm
(Caenorhabditis elegans)
Secernentea pal-16
Protein PAL-1, isoform b (pal-1) mRNA, complete cd...
23(a)
1 → many
III(4804708-4808709) WBGene00003912


ENSEMBL Gene Tree for CDX1 (if available)
TreeFam Gene Tree for CDX1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for CDX1 gene
CDX42  CDX22  
17 SIMAP similar genes for CDX1 using alignment to 4 protein entries:     CDX1_HUMAN (see all proteins):
HOXD11    HOXC13    HOX B6    HMX2    HOXB8    CDX4
HOXA10    HOXB1    DRGX    NKX2-5    CDX2    DLX6
HLX    MSX1    LMX1B    LHX2    NKX2-6

CDX1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for CDX1 (see all 371)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1838426551,2
--149544366(+) CCATGC/TGCTCA 1 -- us2k10--------
rs1452933021,2
--149544367(+) CATGTA/GCTCAT 1 -- us2k10--------
rs1890587681,2
--149544440(+) GCTCCA/GCCCGG 1 -- us2k10--------
rs1926442401,2
--149544540(+) CCTCAA/TTGCTT 1 -- us2k10--------
rs1432704051,2
C--149544715(+) TGGAAA/GGGCCC 1 -- us2k10--------
rs37563151,2
C,F,H--149544722(+) GCCCCA/GGGCTC 1 -- us2k113Minor allele frequency- G:0.34NS EA NA WA 756
rs765825761,2
C,F--149544729(+) GCTCAG/CGTGAA 1 -- us2k15Minor allele frequency- C:0.13NA WA CSA 243
rs1856843741,2
--149544807(+) GCTCCC/TGGCCC 1 -- us2k10--------
rs1905945371,2
--149544954(+) CACATC/TCCTGC 1 -- us2k10--------
rs68722711,2
C,F,A,H--149545043(+) TTGTGA/C/GGGAGG 1 -- us2k112NA WA CSA EA 374

HapMap Linkage Disequilibrium report for CDX1 (149546344 - 149564121 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for CDX1:    About this table    
Variant IDTypeSubtypePubMed ID
nsv883027CNV Loss21882294
nsv883030CNV Loss21882294

Human Gene Mutation Database (HGMD): CDX1
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing CDX1
DNA2.0 Custom Variant and Variant Library Synthesis for CDX1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 600746    OMIM disorders: --

Selected diseases for CDX1 (see all 25):    
About MalaCards
bile reflux    adult acute lymphocytic leukemia    treacher collins syndrome    colon adenocarcinoma
mesenchymal chondrosarcoma    acute lymphocytic leukemia    gastric adenocarcinoma    barrett's esophagus
hirschsprung's disease    duodenitis    esophageal squamous cell carcinoma    colorectal cancer
esophagitis    adenocarcinoma    acute myeloid leukemia    chondrosarcoma
lymphoblastic leukemia    adenoma    myeloid leukemia    cholangiocarcinoma

1 disease from the University of Copenhagen DISEASES database for CDX1:
Bile reflux

CDX1 for disorders           About GeneDecksing

Selected Novoseek inferred disease relationships for CDX1 gene (see all 17)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
metaplasia 72.1 41 19725873 (8), 11871772 (5), 10666391 (4), 15361487 (4) (see all 13)
colon cancer 57.7 19 15215241 (6), 18187048 (3), 14508520 (3), 19900445 (1) (see all 9)
colorectal carcinoma 47.4 10 15378566 (3), 14704280 (2), 19188603 (2), 9593754 (1)
colorectal cancer 44.8 22 16491830 (6), 12124393 (5), 12970739 (2), 10833444 (1) (see all 8)
adenocarcinoma 43.5 12 9247467 (3), 15910596 (2), 15774774 (1), 19106744 (1) (see all 8)
gastric cancer 38.3 4 14615935 (2), 18775915 (2)
colon carcinoma 35.9 4 9593754 (1), 12970739 (1), 15378566 (1)
colon adenocarcinoma 31.1 2 12270138 (1), 9396760 (1)
cancer 27.1 10 9126347 (1), 16491830 (1), 19188603 (1), 12855703 (1) (see all 8)
gastric carcinoma 25.9 5 11790453 (1), 19725873 (1), 14525978 (1)


Export disorders for CDX1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for CDX1 gene, integrated from 10 sources (see all 107):
(articles sorted by number of sources associating them with CDX1)
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  1. Isolation, characterization, and precise physical localization of human CDX1, a caudal-type homeobox gene. (PubMed id 8530027)1, 2, 3, 9 Bonner C.A.... Wasmuth J.J. (Genomics 1995)
  2. Molecular cloning, sequencing and expression of the mRNA encoding human Cdx1 and Cdx2 homeobox. Down-regulation of Cdx1 and Cdx2 mRNA expression during colorectal carcinogenesis. (PubMed id 9036867)1, 2, 9 Mallo G.V.... Iovanna J.L. (Int. J. Cancer 1997)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Loss of CDX1 expression in colorectal carcinoma: promoter methylation, mutation, and loss of heterozygosity analyses of 37 cell lines. (PubMed id 14704280)1, 9 Wong N.A....Bodmer W.F. (Proc. Natl. Acad. Sci. U.S.A. 2004)
  5. Cdx1 autoregulation is governed by a novel Cdx1-LEF1 transcription complex. (PubMed id 15143193)1, 9 BAcland M....Lohnes D. (Mol. Cell. Biol. 2004)
  6. DNA methylation down-regulates CDX1 gene expression in colorectal cancer cell lines. (PubMed id 12124393)1, 9 Suh E.R....Traber P.G. (J. Biol. Chem. 2002)
  7. Gastrointestinal differentiation marker Cytokeratin 20 is regulated by homeobox gene CDX1. (PubMed id 19188603)1, 9 Chan C.W....Bodmer W.F. (Proc. Natl. Acad. Sci. U.S.A. 2009)
  8. Differential regulation of intestinal alkaline phosphatase gene expression by Cdx1 and Cdx2. (PubMed id 15774940)1, 9 Alkhoury F....Hodin R.A. (Am. J. Physiol. Gastrointest. Liver Physiol. 2005)
  9. Putative intestine-specific enhancers located in 5' sequence of the CDX1 gene regulate CDX1 expression in the intestine. (PubMed id 14715525)1, 9 Rankin E.B....Suh E. (Am. J. Physiol. Gastrointest. Liver Physiol. 2004)
  10. Differential regulation of CDX1 and CDX2 gene expression by deficiency in methyl group donors. (PubMed id 18187048)1, 9 Lu X....Namour F. (Biochimie 2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
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  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1044 HGNC: 1805 AceView: CDX1 Ensembl:ENSG00000113722 euGenes: HUgn1044
ECgene: CDX1 H-InvDB: CDX1

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for CDX1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for CDX1 gene:
Search GeneIP for patents involving CDX1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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