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Aliases for CDV3 Gene

Aliases for CDV3 Gene

  • CDV3 Homolog 2 3 5
  • H41 3 4
  • Carnitine Deficiency-Associated Gene Expressed In Ventricle 3 (Mouse) 2
  • Carnitine Deficiency-Associated Gene Expressed In Ventricle 3 3
  • CDV3 Homolog (Mouse) 2
  • Protein CDV3 Homolog 3

External Ids for CDV3 Gene

Previous GeneCards Identifiers for CDV3 Gene

  • GC03P134776
  • GC03P133292
  • GC03P130671

Summaries for CDV3 Gene

GeneCards Summary for CDV3 Gene

CDV3 (CDV3 Homolog) is a Protein Coding gene.

Additional gene information for CDV3 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDV3 Gene

Genomics for CDV3 Gene

Regulatory Elements for CDV3 Gene

Enhancers for CDV3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H133441 1.5 Ensembl ENCODE dbSUPER 11.9 -119.9 -119890 24.8 PKNOX1 FOXA2 SIN3A FEZF1 YY1 TCF12 ZNF766 GATA2 ZNF207 FOS BFSP2 CDV3 TFP1 TOPBP1 RNU6-678P BFSP2-AS1 ENSG00000249820
GH03H133488 1.3 Ensembl ENCODE dbSUPER 12.4 -82.5 -82478 4.9 SIX4 PKNOX1 TBL1XR1 BATF RELA RFX5 GATA3 ZNF157 POLR2A EED CDV3 BFSP2-AS1 TOPBP1 TFP1 BFSP2 GC03P133492 ENSG00000272832
GH03H133546 0.9 Ensembl ENCODE 16.7 -25.8 -25830 2.3 FOXA2 HLF MAX REST RAD21 FOXA1 GATA3 CREB1 HNF4A CDV3 ENSG00000250983 ENSG00000201827
GH03H133473 1.3 Ensembl ENCODE dbSUPER 11.5 -97.1 -97090 5.5 PKNOX1 TBL1XR1 BATF ATF7 ETV6 RUNX3 IKZF2 CREM CBFB JUNB BFSP2 BFSP2-AS1 ENSG00000250983 ENSG00000201827 CDV3 TOPBP1 TFP1 GC03P133476 GC03P133475 GC03P133482
GH03H133479 1.3 Ensembl ENCODE dbSUPER 11.5 -93.4 -93435 1.2 HDGF PKNOX1 FEZF1 ZIC2 RFX5 POLR2A EED PRDM10 RUNX3 KLF8 BFSP2-AS1 ENSG00000250983 ENSG00000201827 CDV3 TFP1 TOPBP1 BFSP2 GC03P133482 GC03P133476 GC03P133475
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CDV3 on UCSC Golden Path with GeneCards custom track

Promoters for CDV3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000158625 910 3001 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9

Genomic Locations for CDV3 Gene

Genomic Locations for CDV3 Gene
chr3:133,573,590-133,590,274
(GRCh38/hg38)
Size:
16,685 bases
Orientation:
Plus strand
chr3:133,292,434-133,309,118
(GRCh37/hg19)

Genomic View for CDV3 Gene

Genes around CDV3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDV3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDV3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDV3 Gene

Proteins for CDV3 Gene

  • Protein details for CDV3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKY7-CDV3_HUMAN
    Recommended name:
    Protein CDV3 homolog
    Protein Accession:
    Q9UKY7
    Secondary Accessions:
    • B3KUC2
    • Q96IP9

    Protein attributes for CDV3 Gene

    Size:
    258 amino acids
    Molecular mass:
    27335 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CDV3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CDV3 Gene

Post-translational modifications for CDV3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CDV3 Gene

Domains & Families for CDV3 Gene

Gene Families for CDV3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for CDV3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CDV3 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKY7

UniProtKB/Swiss-Prot:

CDV3_HUMAN :
  • Belongs to the CDV3 family.
Family:
  • Belongs to the CDV3 family.
genes like me logo Genes that share domains with CDV3: view

Function for CDV3 Gene

Phenotypes From GWAS Catalog for CDV3 Gene

Gene Ontology (GO) - Molecular Function for CDV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CDV3: view

Phenotypes for CDV3 Gene

genes like me logo Genes that share phenotypes with CDV3: view

Animal Model Products

CRISPR Products

miRNA for CDV3 Gene

miRTarBase miRNAs that target CDV3

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CDV3 Gene

Localization for CDV3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDV3 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CDV3 gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoli (4)
  • Plasma membrane (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CDV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with CDV3: view

Pathways & Interactions for CDV3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CDV3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008283 cell proliferation NAS 10497265
genes like me logo Genes that share ontologies with CDV3: view

No data available for Pathways by source and SIGNOR curated interactions for CDV3 Gene

Drugs & Compounds for CDV3 Gene

No Compound Related Data Available

Transcripts for CDV3 Gene

Unigene Clusters for CDV3 Gene

CDV3 homolog (mouse):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDV3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: - - - -
SP2: - -
SP3:
SP4: - - -
SP5:

Relevant External Links for CDV3 Gene

GeneLoc Exon Structure for
CDV3
ECgene alternative splicing isoforms for
CDV3

Expression for CDV3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CDV3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CDV3 Gene

This gene is overexpressed in Muscle - Skeletal (x4.2).

Protein differential expression in normal tissues from HIPED for CDV3 Gene

This gene is overexpressed in Urine (11.6) and Bone marrow stromal cell (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for CDV3 Gene



Protein tissue co-expression partners for CDV3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDV3 Gene:

CDV3

SOURCE GeneReport for Unigene cluster for CDV3 Gene:

Hs.518265

mRNA Expression by UniProt/SwissProt for CDV3 Gene:

Q9UKY7-CDV3_HUMAN
Tissue specificity: Expression levels correlate with those of HER-2/neu in breast cancer cells.

Evidence on tissue expression from TISSUES for CDV3 Gene

  • Liver(4.3)
  • Nervous system(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with CDV3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CDV3 Gene

Orthologs for CDV3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CDV3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDV3 33 34
  • 99.87 (n)
dog
(Canis familiaris)
Mammalia CDV3 33 34
  • 95.1 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 91 (a)
OneToMany
CDV3 33
  • 90.83 (n)
-- 34
  • 74 (a)
OneToMany
mouse
(Mus musculus)
Mammalia LOC102639170 33
  • 88.95 (n)
Cdv3 34
  • 75 (a)
OneToOne
Cdv3-ps 16
platypus
(Ornithorhynchus anatinus)
Mammalia CDV3 34
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cdv3 33
  • 81.88 (n)
oppossum
(Monodelphis domestica)
Mammalia CDV3 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDV3 33 34
  • 69.65 (n)
lizard
(Anolis carolinensis)
Reptilia CDV3 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdv3 33
  • 62.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia cdv3-prov 33
zebrafish
(Danio rerio)
Actinopterygii cdv3 33 34
  • 60 (n)
wufa12e09 33
Species where no ortholog for CDV3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CDV3 Gene

ENSEMBL:
Gene Tree for CDV3 (if available)
TreeFam:
Gene Tree for CDV3 (if available)

Paralogs for CDV3 Gene

Pseudogenes.org Pseudogenes for CDV3 Gene

genes like me logo Genes that share paralogs with CDV3: view

No data available for Paralogs for CDV3 Gene

Variants for CDV3 Gene

Sequence variations from dbSNP and Humsavar for CDV3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000072172 -- 133,572,522(+) GATTC(C/T)ATCTA upstream-variant-2KB
rs1000129865 -- 133,578,220(+) TGGCC(A/G)CAAGT intron-variant
rs1000423489 -- 133,572,812(+) TCTAG(A/G)CTCAA upstream-variant-2KB
rs1000485103 -- 133,573,450(+) CCCGT(C/G)TGGGT upstream-variant-2KB
rs1000486156 -- 133,572,341(+) CCTGA(C/T)CTCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CDV3 Gene

Variant ID Type Subtype PubMed ID
nsv591821 CNV gain 21841781
nsv1073250 CNV deletion 25765185
esv3597846 CNV loss 21293372
esv27719 CNV loss 19812545
esv2674678 CNV deletion 23128226
dgv8610n54 CNV gain 21841781
dgv8609n54 CNV gain 21841781

Variation tolerance for CDV3 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.46; 43.20% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDV3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDV3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDV3 Gene

Disorders for CDV3 Gene

Relevant External Links for CDV3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDV3

No disorders were found for CDV3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CDV3 Gene

Publications for CDV3 Gene

  1. Identification of differentially expressed genes associated with HER-2/neu overexpression in human breast cancer cells. (PMID: 10497265) Oh JJ … Slamon DJ (Nucleic acids research 1999) 2 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. (PMID: 15144186) Brill LM … Peters EC (Analytical chemistry 2004) 3 4 60
  4. Novel mRNA molecules are induced in hypertrophied ventricles of carnitine-deficient mice and belong to a family of up-regulated gene in cells overexpressing c-erbB-2. (PMID: 12359334) Fukumaru S … Saheki T (Biochimica et biophysica acta 2002) 3 22 60
  5. Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress. (PMID: 26472337) Zhu X … Wellmann S (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016) 3 60

Products for CDV3 Gene

Sources for CDV3 Gene

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