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Aliases for CDT1 Gene

Aliases for CDT1 Gene

  • Chromatin Licensing And DNA Replication Factor 1 2 3 5
  • DUP 3 4
  • Double Parked, Drosophila, Homolog Of 3
  • DNA Replication Factor Cdt1 3
  • Double Parked Homolog 4
  • RIS2 3

External Ids for CDT1 Gene

Previous GeneCards Identifiers for CDT1 Gene

  • GC16M080446
  • GC16M090107
  • GC16P088573
  • GC16P088614
  • GC16P087397
  • GC16P088870
  • GC16P074567

Summaries for CDT1 Gene

Entrez Gene Summary for CDT1 Gene

  • The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases results in degradation of the protein. [provided by RefSeq, Mar 2011]

GeneCards Summary for CDT1 Gene

CDT1 (Chromatin Licensing And DNA Replication Factor 1) is a Protein Coding gene. Diseases associated with CDT1 include Meier-Gorlin Syndrome 4 and Meier-Gorlin Syndrome 1. Among its related pathways are E2F mediated regulation of DNA replication and Regulation of activated PAK-2p34 by proteasome mediated degradation.

UniProtKB/Swiss-Prot for CDT1 Gene

  • Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.

Gene Wiki entry for CDT1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CDT1 Gene

Genomics for CDT1 Gene

Regulatory Elements for CDT1 Gene

Enhancers for CDT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16F088854 1.4 FANTOM5 ENCODE 12.2 +53.2 53200 4.2 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZNF207 FOS SP3 APRT CDT1 GALNS ZNF778 CYBA RNF166 ZC3H18 SNAI3 CBFA2T3 TRAPPC2L
GH16F088853 0.3 FANTOM5 12.2 +50.2 50230 0.4 ZKSCAN8 SPI1 APRT CDT1 RNF166 CBFA2T3 SNAI3 TRAPPC2L PIR42461
GH16F088779 1 FANTOM5 ENCODE 12.1 -20.5 -20457 6.7 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 APRT SNORD68 CDT1 GALNS TRAPPC2L RPL13 RNF166 CYBA ENSG00000260121 CDK10
GH16F087819 0.4 ENCODE 11.8 -982.7 -982720 1.0 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 CDT1 KLHDC4 ENSG00000260177 MIR6775
GH16F089503 1.2 FANTOM5 ENCODE 11.8 +703.8 703771 6.1 HDGF PKNOX1 ARNT MLX CREB3L1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 RPL13 SPG7 SNORD68 CDT1 RNU6-430P APRT DBNDD1 ZNF276 SPATA2L ANKRD11
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CDT1 on UCSC Golden Path with GeneCards custom track

Promoters for CDT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000054063 287 2601 CREB3L1 ARID4B SIN3A DMAP1 ZNF766 ZNF207 SP3 SP5 ZHX2 MXD4

Genomic Location for CDT1 Gene

Chromosome:
16
Start:
88,803,213 bp from pter
End:
88,809,258 bp from pter
Size:
6,046 bases
Orientation:
Plus strand

Genomic View for CDT1 Gene

Genes around CDT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CDT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CDT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CDT1 Gene

Proteins for CDT1 Gene

  • Protein details for CDT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H211-CDT1_HUMAN
    Recommended name:
    DNA replication factor Cdt1
    Protein Accession:
    Q9H211
    Secondary Accessions:
    • Q86XX9
    • Q96CJ5
    • Q96GK5
    • Q96H67
    • Q96HE6
    • Q9BWM0

    Protein attributes for CDT1 Gene

    Size:
    546 amino acids
    Molecular mass:
    60390 Da
    Quaternary structure:
    • Interacts with GMNN; inhibits both binding of the MCM complex to origins of replication and DNA-binding activity. Interacts with PCNA. Interacts with LRWD1 during G1 phase and during mitosis.
    SequenceCaution:
    • Sequence=AF070552; Type=Frameshift; Positions=278, 312; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CDT1 Gene

neXtProt entry for CDT1 Gene

Post-translational modifications for CDT1 Gene

  • Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and subsequent degradation. Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to stress. Binding to GMNN is not affected by phosphorylation.
  • Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, in response to DNA damage, leading to its degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the K+4 motif in the PIP box, recruit the DCX(DTL) complex, leading to its degradation. The interaction with GMNN protects it against ubiquitination.
  • Ubiquitination at Lys 24, Lys 166, Lys 189, Lys 240, and Lys 377
  • Modification sites at PhosphoSitePlus

Other Protein References for CDT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CDT1 (CDT1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CDT1

No data available for DME Specific Peptides for CDT1 Gene

Domains & Families for CDT1 Gene

Protein Domains for CDT1 Gene

Suggested Antigen Peptide Sequences for CDT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H211

UniProtKB/Swiss-Prot:

CDT1_HUMAN :
  • The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
  • Belongs to the Cdt1 family.
Domain:
  • The PIP-box K+4 motif mediates both the interaction with PCNA and the recruitment of the DCX(DTL) complex: while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its ubiquitination.
Family:
  • Belongs to the Cdt1 family.
genes like me logo Genes that share domains with CDT1: view

No data available for Gene Families for CDT1 Gene

Function for CDT1 Gene

Molecular function for CDT1 Gene

UniProtKB/Swiss-Prot Function:
Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and conformation-independent manner. Potential oncogene.

Gene Ontology (GO) - Molecular Function for CDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding ISS --
GO:0005515 protein binding IPI 11125146
genes like me logo Genes that share ontologies with CDT1: view
genes like me logo Genes that share phenotypes with CDT1: view

Human Phenotype Ontology for CDT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CDT1 Gene

Localization for CDT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CDT1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CDT1 Gene COMPARTMENTS Subcellular localization image for CDT1 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IDA 11125146
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with CDT1: view

Pathways & Interactions for CDT1 Gene

genes like me logo Genes that share pathways with CDT1: view

SIGNOR curated interactions for CDT1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CDT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000076 DNA replication checkpoint IDA 14672932
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication IEA --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with CDT1: view

Drugs & Compounds for CDT1 Gene

(1) Drugs for CDT1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with CDT1: view

Transcripts for CDT1 Gene

mRNA/cDNA for CDT1 Gene

Unigene Clusters for CDT1 Gene

Chromatin licensing and DNA replication factor 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CDT1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
SP1:
SP2: -

Relevant External Links for CDT1 Gene

GeneLoc Exon Structure for
CDT1
ECgene alternative splicing isoforms for
CDT1

Expression for CDT1 Gene

mRNA expression in normal human tissues for CDT1 Gene

Protein differential expression in normal tissues from HIPED for CDT1 Gene

This gene is overexpressed in Heart (64.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CDT1 Gene



Protein tissue co-expression partners for CDT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CDT1 Gene:

CDT1

SOURCE GeneReport for Unigene cluster for CDT1 Gene:

Hs.122908
genes like me logo Genes that share expression patterns with CDT1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CDT1 Gene

Orthologs for CDT1 Gene

This gene was present in the common ancestor of animals.

Orthologs for CDT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CDT1 34 35
  • 97.59 (n)
cow
(Bos Taurus)
Mammalia CDT1 34 35
  • 81.26 (n)
dog
(Canis familiaris)
Mammalia CDT1 34 35
  • 79.95 (n)
rat
(Rattus norvegicus)
Mammalia Cdt1 34
  • 76.14 (n)
mouse
(Mus musculus)
Mammalia Cdt1 34 16 35
  • 75.58 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CDT1 35
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CDT1 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves CDT1 34 35
  • 62.98 (n)
lizard
(Anolis carolinensis)
Reptilia CDT1 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cdt1 34
  • 59.69 (n)
Str.3346 34
African clawed frog
(Xenopus laevis)
Amphibia cdt1 34
zebrafish
(Danio rerio)
Actinopterygii cdt1 34 35
  • 58.76 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2597 34
fruit fly
(Drosophila melanogaster)
Insecta dup 36 35
  • 34 (a)
worm
(Caenorhabditis elegans)
Secernentea cdt-1 35
  • 18 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9171 35
  • 40 (a)
OneToOne
Species where no ortholog for CDT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CDT1 Gene

ENSEMBL:
Gene Tree for CDT1 (if available)
TreeFam:
Gene Tree for CDT1 (if available)

Paralogs for CDT1 Gene

No data available for Paralogs for CDT1 Gene

Variants for CDT1 Gene

Sequence variations from dbSNP and Humsavar for CDT1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs200652608 Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804], Pathogenic 88,807,407(+) TGTCC(A/C/G)AACGC reference, missense
rs200672589 Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804] 88,807,362(+) TAGAA(C/T)GGCTG reference, missense
rs387906917 Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804], Pathogenic 88,807,390(+) GCTGC(A/G)GAGCG reference, missense
rs387906918 Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804], Pathogenic 88,804,027(+) CACCG(A/G)CCCGC reference, missense
rs779871947 Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804] 88,804,667(+) GACCA(C/G)GTGAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CDT1 Gene

Variant ID Type Subtype PubMed ID
dgv3064n100 CNV gain 25217958
dgv3065n100 CNV gain 25217958
dgv37n68 CNV loss 17160897
dgv5313n54 CNV loss 21841781
dgv5319n54 CNV loss 21841781
esv3639555 CNV gain 21293372
esv3892938 CNV loss 25118596
nsv1061256 CNV gain 25217958
nsv1063024 CNV gain 25217958
nsv1063441 CNV loss 25217958
nsv1070367 CNV deletion 25765185
nsv457617 CNV gain 19166990
nsv471115 CNV loss 18288195
nsv471117 CNV gain 18288195
nsv482951 CNV loss 15286789
nsv521217 CNV loss 19592680
nsv528898 CNV loss 19592680
nsv573674 CNV gain 21841781
nsv573677 CNV loss 21841781
nsv573712 CNV loss 21841781
nsv573714 CNV gain 21841781
nsv573715 CNV loss 21841781
nsv573718 CNV loss 21841781
nsv819907 CNV gain 19587683
nsv952071 CNV deletion 24416366

Variation tolerance for CDT1 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.40; 54.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CDT1 Gene

Human Gene Mutation Database (HGMD)
CDT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CDT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CDT1 Gene

Disorders for CDT1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CDT1 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
meier-gorlin syndrome 4
  • mgors4
meier-gorlin syndrome 1
  • meier-gorlin syndrome
- elite association - COSMIC cancer census association via MalaCards
Search CDT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CDT1_HUMAN
  • Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804]: A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. {ECO:0000269 PubMed:21358631, ECO:0000269 PubMed:21358632}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for CDT1

Genetic Association Database (GAD)
CDT1
Human Genome Epidemiology (HuGE) Navigator
CDT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CDT1
genes like me logo Genes that share disorders with CDT1: view

No data available for Genatlas for CDT1 Gene

Publications for CDT1 Gene

  1. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PMID: 16949367) Jin J. … Walter J.C. (Mol. Cell 2006) 3 4 22 64
  2. The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. (PMID: 17029205) Gao J. … Shen H.B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006) 3 22 46 64
  3. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PMID: 14993212) Sugimoto N. … Fujita M. (J. Biol. Chem. 2004) 3 4 22 64
  4. Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. (PMID: 15257290) Ballabeni A. … Helin K. (EMBO J. 2004) 3 4 22 64
  5. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. (PMID: 11555648) Nishitani H. … Nishimoto T. (J. Biol. Chem. 2001) 2 3 22 64

Products for CDT1 Gene

Sources for CDT1 Gene

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