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CDT1 Gene

protein-coding   GIFtS: 63
GCID: GC16P088870

Chromatin Licensing And DNA Replication Factor 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromatin Licensing And DNA Replication Factor 11 2
DUP2 3
RIS22
DNA Replication Factor Cdt12
Double Parked, Drosophila, Homolog Of2
Double Parked Homolog3

External Ids:    HGNC: 245761   Entrez Gene: 816202   Ensembl: ENSG000001675137   OMIM: 6055255   UniProtKB: Q9H2113   

Export aliases for CDT1 gene to outside databases

Previous GC identifers: GC16M080446 GC16M090107 GC16P088573 GC16P088614 GC16P087397 GC16P074567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CDT1 Gene:
The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for
DNA replication. The encoded protein can bind geminin, which prevents replication and may function to prevent
this protein from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin
A-dependent kinases results in degradation of the protein. (provided by RefSeq, Mar 2011)

GeneCards Summary for CDT1 Gene:
CDT1 (chromatin licensing and DNA replication factor 1) is a protein-coding gene. Diseases associated with CDT1 include meier-gorlin syndrome 4, and meier-gorlin syndrome 1.

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211
Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to
form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and
conformation-independent manner. Potential oncogene

Gene Wiki entry for CDT1 (DNA replication factor CDT1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CDT1 gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-1   E2F   p53   E2F-2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDT1 promoter sequence
   Search Chromatin IP Primers for CDT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CDT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3   Ensembl cytogenetic band:  16q24.3   HGNC cytogenetic band: 16q24.3

CDT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDT1 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P088870:  view genomic region     (about GC identifiers)

Start:
88,869,621 bp from pter      End:
88,875,666 bp from pter
Size:
6,046 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211 (See protein sequence)
Recommended Name: DNA replication factor Cdt1  
Size: 546 amino acids; 60390 Da
Subunit: Interacts with GMNN; inhibits both binding of the MCM complex to origins of replication and DNA-binding
activity. Interacts with PCNA. Interacts with LRWD1 during G1 phase and during mitosis
Developmental stage: Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M
phases
Sequence caution: Sequence=AF070552; Type=Frameshift; Positions=278, 312;
2 PDB 3D structures from and Proteopedia for CDT1:
2LE8 (3D)        2WVR (3D)    
Secondary accessions: Q86XX9 Q96CJ5 Q96GK5 Q96H67 Q96HE6 Q9BWM0

Explore the universe of human proteins at neXtProt for CDT1: NX_Q9H211

Explore proteomics data for CDT1 at MOPED

Post-translational modifications: 

  • Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, in response to DNA damage, leading to its
    degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is
    PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the
    PIP box, recruit the DCX(DTL) complex, leading to its degradation. The interaction with GMNN protects it against
    ubiquitination1
  • Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and
    subsequent degradation. Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to
    stress. Binding to GMNN is not affected by phosphorylation1
  • Ubiquitination2 at Lys24, Lys166, Lys189, Lys240, Lys377
  • Modification sites at PhosphoSitePlus

  • See CDT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112190.2  
    ENSEMBL proteins: 
     ENSP00000301019   ENSP00000456926  
    Reactome Protein details: Q9H211

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    CDT1 Assay Products:

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    Cloud-Clone Corp. CLIAs for CDT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR014939 CDT1_Gemini-bd-like

    Graphical View of Domain Structure for InterPro Entry Q9H211

    ProtoNet protein and cluster: Q9H211

    UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211
    Domain: The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex:
    while the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading
    to its ubiquitination (By similarity)
    Similarity: Belongs to the Cdt1 family


    CDT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CDT1_HUMAN, Q9H211
    Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to
    form the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and
    conformation-independent manner. Potential oncogene

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding ISS--
    GO:0005515protein binding IPI11125146
         
    CDT1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CDT1:
     Decreased Wnt reporter activit  Increased cell number in S 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CDT1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CDT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CDT1

    miRNA
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    miRTarBase miRNAs that target CDT1:
    hsa-mir-20a-5p (MIRT050529), hsa-mir-193b-3p (MIRT016534), hsa-mir-186-5p (MIRT045201)

    Block miRNA regulation of human, mouse, rat CDT1 using miScript Target Protectors
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    SwitchGear 3'UTR luciferase reporter plasmidCDT1 3' UTR sequence
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    Predesigned siRNA for gene silencing in human, mouse, rat CDT1

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    GenScript: all cDNA clones in your preferred vector: CDT1 (NM_030928)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CDT1

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CDT1_HUMAN, Q9H211: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005654nucleoplasm TAS--
    GO:0005829cytosol TAS--

    CDT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CDT1 About   (see all 9)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2CDK-mediated phosphorylation and removal of Cdc6
    Switching of origins to a post-replicative state0.93
    CDT1 association with the CDC6-ORC-origin complex0.87
    Orc1 removal from chromatin0.93
    Removal of licensing factors from origins0.86
    Regulation of DNA replication0.93
    M/G1 Transition0.81
    Synthesis of DNA0.92
    DNA Replication Pre-Initiation0.81
    3E2F mediated regulation of DNA replication
    G1/S Transition0.81
    E2F mediated regulation of DNA replication0.30
    Mitotic G1-G1/S phases0.81
    G1/S-Specific Transcription0.00
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5Cell cycle Regulation of G1 S transition part 1
    Cell cycle Role of SCF complex in cell cycle regulation0.39

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CDT1
        Cell Cycle Control of Chromosomal Replication

    1 Cell Signaling Technology (CST) Pathway for CDT1
        Cell Cycle / Checkpoint Control

    2 GeneGo (Thomson Reuters) Pathways for CDT1
        Cell cycle Start of DNA replication in early S phase
    Cell cycle Role of SCF complex in cell cycle regulation

    2 BioSystems Pathways for CDT1
        DNA Replication
    RB in Cancer

    Selected Reactome Pathways for CDT1 (see all 8)
        Removal of licensing factors from origins
    Orc1 removal from chromatin
    E2F mediated regulation of DNA replication
    G1/S-Specific Transcription
    Assembly of the pre-replicative complex



    CDT1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CDT1
    Interactions:

        GeneGlobe Interaction Network for CDT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CDT1 (Q9H2111, 2, 3 ENSP000003010194) via UniProtKB, MINT, STRING, and/or I2D (see all 154)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PCNAP120041, 2, 3, ENSP000003684384EBI-456953,EBI-358311 MINT-1955576 MINT-1955474 I2D: score=4 STRING: ENSP00000368438
    ORC2Q134162, 3, ENSP000002342964MINT-50426 I2D: score=6 STRING: ENSP00000234296
    GMNNO754961, 2, 3, ENSP000002300564EBI-456953,EBI-371669 MINT-1955603 MINT-4508837 MINT-50424 MINT-4508819 I2D: score=7 STRING: ENSP00000230056
    CDC6Q997411, 2, 3, ENSP000002097284EBI-456953,EBI-374862 MINT-50423 I2D: score=6 STRING: ENSP00000209728
    MCM6Q145661, 3, ENSP000002641564EBI-456953,EBI-374900 I2D: score=4 STRING: ENSP00000264156
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000076DNA replication checkpoint IDA14672932
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000083regulation of transcription involved in G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication IEA--

    CDT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CDT1

    1 Novoseek inferred chemical compound relationship for CDT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    atp 18.6 6 16387651 (2), 11741544 (1), 11737877 (1), 16428461 (1)



    CDT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CDT1 gene: 
    NM_030928.3  

    Unigene Cluster for CDT1:

    Chromatin licensing and DNA replication factor 1
    Hs.122908  [show with all ESTs]
    Unigene Representative Sequence: AB053172
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301019(uc002flu.3) ENST00000562747 ENST00000569140
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CDT1
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    Additional mRNA sequence: 

    AB053172.1 AF070552.1 AF321125.1 BC000137.2 BC008676.1 BC008860.2 BC009410.1 BC014202.2 
    BC021126.1 BC049205.1 

    11 DOTS entries:

    DT.455965  DT.100786092  DT.100759637  DT.121641720  DT.91874678  DT.97848222  DT.100837111  DT.100029168 
    DT.100786083  DT.121207297  DT.422791 

    Selected AceView cDNA sequences (see all 235):

    CR609788 AI872096 BM450908 CR600099 BM783379 BQ053454 BE018212 BX401885 
    BX421258 BU859159 CR610728 CR625627 CR613446 BQ063175 CR613412 BU164161 
    CR603023 CR598796 BM783362 CA422735 BE502560 BE301693 BM783501 CA432508 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CDT1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10
    SP1:                                                                              
    SP2:                                                  -                           


    ECgene alternative splicing isoforms for CDT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CDT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGCTCACCT
    CDT1 Expression
    About this image


    CDT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    CDT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CDT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122908
        Custom PCR Arrays for CDT1
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CDT1 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cdt11 , 5 chromatin licensing and DNA replication factor 11, 5 75.58(n)1
    74.95(a)1
      8 (71.91 cM)5
    671771  NM_026014.31  NP_080290.31 
     1225680155 
    chicken
    (Gallus gallus)
    Aves CDT11 chromatin licensing and DNA replication factor 1 62.98(n)
    55.72(a)
      426254  XM_423919.4  XP_423919.4 
    lizard
    (Anolis carolinensis)
    Reptilia CDT16
    chromatin licensing and DNA replication factor 1
    50(a)
    1 ↔ 1
    GL343948.1(85057-103325)
    African clawed frog
    (Xenopus laevis)
    Amphibia cdt12 putative CDT1 protein 71.46(n)    AJ250122.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cdt11 chromatin licensing and DNA replication factor 1 58.76(n)
    55.48(a)
      566787  XM_690072.5  XP_695164.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta dup3 DNA replication DNA binding 34(a)   51F11   --
    worm
    (Caenorhabditis elegans)
    Secernentea cdt-16
    Protein CDT-1 (cdt-1) mRNA, complete cds
    18(a)
    1 ↔ 1
    I(3223162-3228022) WBGene00000413


    ENSEMBL Gene Tree for CDT1 (if available)
    TreeFam Gene Tree for CDT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CDT1 (see all 350)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0654914
    Meier-Gorlin syndrome 4 (MGORS4)4--see VAR_0654912 R Q mis40--------
    VAR_0654924
    Meier-Gorlin syndrome 4 (MGORS4)4--see VAR_0654922 E K mis40--------
    VAR_0654884
    Meier-Gorlin syndrome 4 (MGORS4)4--see VAR_0654882 A T mis40--------
    VAR_0654894
    Meier-Gorlin syndrome 4 (MGORS4)4--see VAR_0654892 Q H mis40--------
    VAR_0654904
    Meier-Gorlin syndrome 4 (MGORS4)4--see VAR_0654902 R W mis40--------
    rs1505260541,2
    --88868191(+) TATTTA/CTTGAC 1 -- us2k10--------
    rs795459221,2
    F--88868216(+) CTACCA/GGCTGC 1 -- us2k11Minor allele frequency- G:0.06WA 118
    rs1149554381,2
    F--88868237(+) CAGGTC/GTAGGT 1 -- us2k11Minor allele frequency- G:0.02WA 118
    rs5652111,2
    C,F,A,H--88868252(+) ATCCCC/TTATAT 1 -- us2k127Minor allele frequency- T:0.41EA NA MN NS WA CSA 2925
    rs781910121,2
    C,F--88868281(+) CCTCAG/CCACGC 1 -- us2k11Minor allele frequency- C:0.50WA 2

    HapMap Linkage Disequilibrium report for CDT1 (88869621 - 88875666 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CDT1 (see all 28):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv37n68CNV Loss17160897
    dgv2995n71CNV Loss21882294
    nsv907278CNV Loss21882294
    nsv907268CNV Loss21882294
    nsv907336CNV Loss21882294
    dgv2991n71CNV Loss21882294
    nsv521217CNV Loss19592680
    nsv907226CNV Loss21882294
    nsv907322CNV Loss21882294
    dgv2988n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): CDT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CDT1
    DNA2.0 Custom Variant and Variant Library Synthesis for CDT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605525   
    OMIM disorders: 613804  
    UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211
  • Meier-Gorlin syndrome 4 (MGORS4) [MIM:613804]: A syndrome characterized by bilateral microtia,
    aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature
    and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently
    low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract
    anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial
    prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic
    patella are absent in some. Despite the presence of microcephaly, intellect is usually normal. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • Selected diseases for CDT1 (see all 27):    
    About MalaCards
    meier-gorlin syndrome 4    meier-gorlin syndrome 1    meier-gorlin syndrome    lymphoblastic lymphoma
    microtia    seckel syndrome    dwarfism    mantle cell lymphoma
    microcephaly    short stature    cleft palate    acute leukemia
    pancreatic cancer    tonsillitis    pancreatitis    colorectal cancer
    prostatitis    prostate cancer    hiv-1    multiple myeloma

    1 disease from the University of Copenhagen DISEASES database for CDT1:
    Seckel syndrome

    CDT1 for disorders           About GeneDecksing

    3 Novoseek inferred disease relationships for CDT1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 23.3 16 19487297 (2), 16835273 (2), 18508524 (2), 15291814 (2) (see all 7)
    colon cancer 0 2 16273206 (2)
    tumors 0 3 18508524 (1), 8144677 (1)

    Genetic Association Database (GAD): CDT1
    Human Genome Epidemiology (HuGE) Navigator: CDT1 (1 document)

    Export disorders for CDT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CDT1 gene, integrated from 10 sources (see all 187):
    (articles sorted by number of sources associating them with CDT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PubMed id 14993212)1, 2, 9 Sugimoto N.... Fujita M. (J. Biol. Chem. 2004)
    2. Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. (PubMed id 11125146)1, 2, 9 Wohlschlegel J.A....Dutta A. (Science 2000)
    3. Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. (PubMed id 15257290)1, 2, 9 Ballabeni A....Helin K. (EMBO J. 2004)
    4. The association of polymorphisms of CDT1 and GMNN gene with the risk of breast cancer in Chinese women: a case-control analysis. (PubMed id 17029205)1, 4, 9 Gao J....Shen H.B. (Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2006)
    5. The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. (PubMed id 11555648)1, 3, 9 Nishitani H....Nishimoto T. (J. Biol. Chem. 2001)
    6. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)1, 2, 9 Jin J.... Walter J.C. (Mol. Cell 2006)
    7. JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. (PubMed id 21856198)1, 2 Miotto B. and Struhl K. (Mol. Cell 2011)
    8. Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)1, 2 Bicknell L.S....Jackson A.P. (Nat. Genet. 2011)
    9. Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. (PubMed id 21358631)1, 2 Guernsey D.L.... Samuels M.E. (Nat. Genet. 2011)
    10. L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. (PubMed id 16861906)1, 2 Higa L.A.... Zhang H. (Cell Cycle 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81620 HGNC: 24576 AceView: CDT1 Ensembl:ENSG00000167513 euGenes: HUgn81620
    ECgene: CDT1 H-InvDB: CDT1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CDT1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CDT1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CDT1 gene:
    Search GeneIP for patents involving CDT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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