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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CDT1 Gene

protein-coding GIFtS: 61
GCID: GC16P088870

chromatin licensing and DNA replication factor 1

Explore 17 diseases affiliated with
CDT1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromatin Licensing And DNA Replication Factor 1¹ ²
DUP¹ ² ³
RIS2¹ ²
DNA Replication Factor Cdt1²
Double Parked, Drosophila, Homolog Of²
Double Parked Homolog³

External Ids:	HGNC: 24576¹	Entrez Gene: 81620²	Ensembl: ENSG00000167513⁷	OMIM: 605525⁵	UniProtKB: Q9H211³

Export aliases for CDT1 gene to outside databases

Previous GC identifers: GC16M080446 GC16M090107 GC16P088573 GC16P088614 GC16P087397 GC16P074567

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CDT1:

The protein encoded by this gene is involved in the formation of the pre-replication complex that is necessary for DNA

replication. The encoded protein can bind geminin, which prevents replication and may function to prevent this protein

from initiating replication at inappropriate origins. Phosphorylation of this protein by cyclin A-dependent kinases

results in degradation of the protein. (provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211

Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form

the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and

conformation-independent manner. Potential oncogene

Gene Wiki entry for CDT1 (DNA replication factor CDT1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010542.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CDT1 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-1 E2F p53 E2F-2 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CDT1 promoter sequence

Search SABiosciences Chromatin IP Primers for CDT1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CDT1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q24.3 Ensembl cytogenetic band: 16q24.3 HGNC cytogenetic band: 16q24.3

CDT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CDT1 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P088870: view genomic region (about GC identifiers)

Start:	88,869,621 bp from pter	End:	88,875,666 bp from pter
Size:	6,046 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211 (See protein sequence)

Recommended Name: DNA replication factor Cdt1

Size: 546 amino acids; 60390 Da

Subunit: Interacts with GMNN; inhibits both binding of the MCM complex to origins of replication and DNA-binding

activity. Interacts with PCNA

Subcellular location: Nucleus

Developmental stage: Present during G1 and early S phase of the cell cycle. Degraded during the late S, G2, and M

phases

Sequence caution: Sequence=AF070552; Type=Frameshift; Positions=278, 312;

2 PDB 3D structures from and Proteopedia for CDT1:

2LE8 (3D)

2WVR (3D)

Secondary accessions: Q86XX9 Q96CJ5 Q96GK5 Q96H67 Q96HE6 Q9BWM0

Explore the universe of human proteins at neXtProt for CDT1: NX_Q9H211

Post-translational modifications:

Ubiquitinated by the DCX(DTL) complex, also named CRL4(CDT2) complex, in response to DNA damage, leading to its

degradation. Ubiquitination by the DCX(DTL) complex is necessary to ensure proper cell cycle regulation and is

PCNA-dependent: interacts with PCNA via its PIP-box, while the presence of the containing the 'K+4' motif in the PIP

box, recruit the DCX(DTL) complex, leading to its degradation. The interaction with GMNN protects it against

ubiquitination¹

Phosphorylated by cyclin A-dependent kinases which results in the binding of CDT1 to the F-box protein SKP2 and

subsequent degradation. Phosphorylated at Thr-29 by MAPK8/JNK1, which blocks replication licensing in response to

stress. Binding to GMNN is not affected by phosphorylation¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H211

CDT1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_112190.2

ENSEMBL proteins:

ENSP00000301019 ENSP00000456926

Reactome Protein details: Q9H211
Human Recombinant Protein Products:

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	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CDT1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005829	cytosol	TAS	--

CDT1 for ontologies About GeneDecksing

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	GenScript Custom Assay Services for CDT1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CDT1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CDT1 for domains About GeneDecksing

1 InterPro domain/family:

IPR014939 CDT1_Gemini-bd-like

Graphical View of Domain Structure for InterPro Entry Q9H211

ProtoNet protein and cluster: Q9H211

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211

Domain: The PIP-box K+4 motif mediates both the interaction with PCNA and the recuitment of the DCX(DTL) complex: while

the PIP-box interacts with PCNA, the presence of the K+4 submotif, recruits the DCX(DTL) complex, leading to its

ubiquitination (By similarity)

Similarity: Belongs to the Cdt1 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211

Function: Cooperates with CDC6 to promote the loading of the mini-chromosome maintenance complex onto chromatin to form

the pre-replication complex necessary to initiate DNA replication. Binds DNA in a sequence-, strand-, and

conformation-independent manner. Potential oncogene

miRNA Products:		OriGene 3'-UTR Clone: CDT1 Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CDT1 (see all 7) OriGene shRNA RFP: CDT1 OriGene siRNA: CDT1
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Gene Editing
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		Search LifeMap BioReagents cell lines for CDT1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDT1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	ISS	--
GO:0005515	protein binding	IPI	--

CDT1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CDT1:

Decreased Wnt reporter activit

Increased cell number in S

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Ubiquitinated Orc1 is degraded by the proteasome

8/11 pathways (see all 11)
CDT1 association with the CDC6:ORC:origin complex	0.84	DNA Replication Pre-Initiation	0.62
Assembly of the pre-replicative complex	0.77	M/G1 Transition	0.62
Switching of origins to a post-replicative state	0.70	Synthesis of DNA	0.51
Orc1 removal from chromatin	0.70	DNA Replication	0.49

G1/S-Specific Transcription

	G1/S-Specific Transcription	1.00			E2F mediated regulation of DNA replication	0.45
	Activation of E2F target genes at G1/S	1.00

Cell cycle_Role of SCF complex in cell cycle regulation

Cell cycle_Role of SCF complex in cell cycle regulation

1.00

Cell cycle Role of SCF complex in cell cycle regulation

0.98

Cell cycle_Start of DNA replication in early S phase

Cell cycle_Start of DNA replication in early S phase

1.00

Cell cycle Start of DNA replication in early S phase

0.98

Cell Cycle

Cell Cycle

1.00

Cell Cycle, Mitotic

0.84

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CDT1

	Meiosis
	Cell cycle Start of DNA replication in early S phase
	Cell cycle Role of SCF complex in cell cycle regulation

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CDT1

Cell Cycle Control of Chromosomal Replication

1 Cell Signaling Technology (CST) Pathway for CDT1

Cell Cycle / Checkpoint Control

2 GeneGo (Thomson Reuters) Pathways for CDT1

	Cell cycle Start of DNA replication in early S phase
	Cell cycle Role of SCF complex in cell cycle regulation

1 BioSystems Pathway for CDT1

DNA Replication

5/21 Reactome Pathways for CDT1 (see all 21)

	Mitotic G1-G1/S phases
	DNA Replication
	Removal of licensing factors from origins
	Cell Cycle
	Orc1 removal from chromatin

CDT1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CDT1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/112 Interacting proteins for CDT1 (Q9H211^{1, 2, 3} ENSP00000301019⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 112)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CDC6	Q99741¹^,²^,³, ENSP00000209728⁴	EBI-456953,EBI-374862 MINT-50423 I2D: score=6 STRING: ENSP00000209728
PCNA	P12004²^,³, ENSP00000368438⁴	MINT-1955576 MINT-1955474 I2D: score=4 STRING: ENSP00000368438
ORC2	Q13416²^,³, ENSP00000234296⁴	MINT-50426 I2D: score=6 STRING: ENSP00000234296
ORC1	Q13415²^,³, ENSP00000360621⁴	MINT-50425 I2D: score=5 STRING: ENSP00000360621
HAUS1	Q96CS2²^,³, ENSP00000282058⁴	MINT-50422 I2D: score=1 STRING: ENSP00000282058

About this table

Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000076	DNA replication checkpoint	IDA	14672932
GO:0000082	G1/S transition of mitotic cell cycle	TAS	--
GO:0000083	regulation of transcription involved in G1/S phase of mitotic cell cycle	TAS	--
GO:0000084	S phase of mitotic cell cycle	TAS	--
GO:0000216	M/G1 transition of mitotic cell cycle	TAS	--

CDT1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CDT1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CDT1
1 Novoseek chemical compound relationship for CDT1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
atp	18.6	6	16387651 (2), 11741544 (1), 11737877 (1), 16428461 (1)

Search CenterWatch for drugs/clinical trials and news about CDT1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CDT1 gene:

NM_030928.3

Unigene Cluster for CDT1:

Chromatin licensing and DNA replication factor 1

Hs.122908 [show with all ESTs]

Unigene Representative Sequence: AB053172

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000301019(uc002flu.3) ENST00000562747 ENST00000569140

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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB053172.1 AF070552.1 AF321125.1 BC000137.2 BC008676.1 BC008860.2 BC009410.1 BC014202.2

BC021126.1 BC049205.1

11 DOTS entries:

DT.455965 DT.100786092 DT.100759637 DT.121641720 DT.91874678 DT.97848222 DT.100837111 DT.100029168

DT.100786083 DT.121207297 DT.422791

24/235 AceView cDNA sequences (see all 235):

BM783362 CR603023 BU522023 BQ053454 BM927844 CR613446 BU176676 CR609788

BM463356 CR614189 BM450908 BU189533 BU859159 BX421258 BE502560 CR600099

BM783379 BE301693 CR596577 CR625627 BM758710 AI872096 BC009410 CR613412

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for CDT1 About this scheme

ExUns:	1	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	^	8	^	9a	·	9b	^	10
SP1:
SP2:																	-

ECgene alternative splicing isoforms for CDT1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CDT1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGGCTCACCT

About this image

CDT1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CDT1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CDT1

SOURCE GeneReport for Unigene cluster: Hs.122908

SABiosciences Custom PCR Arrays for CDT1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CDT1 Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CDT1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CDT1 gene from 7/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cdt1^{1 , 5}	chromatin licensing and DNA replication factor 1^{1, 5}	76.39(n)¹ 76.07(a)¹		8 (71.91 cM)⁵ 67177¹ NM_026014.3¹ NP_080290.3¹ 122568015⁵
chicken (Gallus gallus)	Aves	CDT1¹	chromatin licensing and DNA replication factor 1	63.23(n) 55.53(a)		426254 XM_423919.3 XP_423919.3
lizard (Anolis carolinensis)	Reptilia	CDT1⁶	--	65(a)	1 ↔ 1	GL343948.1(88558-97681)
African clawed frog (Xenopus laevis)	Amphibia	cdt1²	putative CDT1 protein	71.46(n)		AJ250122.1
zebrafish (Danio rerio)	Actinopterygii	cdt1¹	chromatin licensing and DNA replication factor 1	54.62(n) 50(a)		566787 XM_002662943.1 XP_002662989.1
fruit fly (Drosophila melanogaster)	Insecta	dup^{1 , 3}	DNA replication DNA binding³ double parked¹	34(a)³ 53.01(n)¹ 40.43(a)¹		51F11³ 47121¹ NM_080139.4¹ NP_524878.1¹
worm (Caenorhabditis elegans)	Secernentea	cdt-1⁶	CDT (S. pombe CDC10 Dependent Transcript) homolog ...	16(a)	1 ↔ 1	I(3223164-3228024)

ENSEMBL Gene Tree for CDT1 (if available)
TreeFam Gene Tree for CDT1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150526054^1,2		--	88868191(+)	`TATTTA/CTTGAC`	1	--	us2k¹		0	--	--	--	--
rs79545922^1,2	F,	--	88868216(+)	`CTACCA/GGCTGC`	1	--	us2k¹		1		WA	118
rs114955438^1,2	F,	--	88868237(+)	`CAGGTC/GTAGGT`	1	--	us2k¹		1		WA	118
rs565211^1,2	C,F,A,H,	--	88868252(+)	`ATCCCC/TTATAT`	1	--	us2k¹		27		EA NA MN NS WA CSA	2925
rs78191012^1,2	C,	--	88868281(+)	`CCTCAG/CCACGC`	1	--	us2k¹		1		WA	2
rs143218521^1,2		--	88868376(+)	`CTGGAA/GTGTAG`	1	--	us2k¹		0	--	--	--	--
rs146659015^1,2		--	88868385(+)	`AGTGGC/TGGGAT`	1	--	us2k¹		0	--	--	--	--
rs190554710^1,2		--	88868418(+)	`TGCCTA/GCCATC`	1	--	us2k¹		0	--	--	--	--
rs111504770^1,2		--	88868458(+)	`GAGACA/GGGGTT`	1	--	us2k¹		2		CSA	3
rs144131926^1,2		--	88868487(+)	`TGGTCC/TTGAAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CDT1 (88869621 - 88875666 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for CDT1
5 CNVs: 59565 30015 59564 4976 4975
Human Gene Mutation Database (HGMD): CDT1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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CDT1 for disorders About GeneDecksing

OMIM gene information: 605525 OMIM disorders: --

UniProtKB/Swiss-Prot: CDT1_HUMAN, Q9H211

Defects in CDT1 are the cause of Meier-Gorlin syndrome type 4 (MGORS4) [MIM:613804]. MGORS4 is a syndrome

characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth

retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial

sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate,

micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial

dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and

absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal

17 diseases for CDT1: About MalaCards

meier-gorlin syndrome intrauterine and postnatal growth retardation short stature mantle cell lymphoma

microtia dwarfism lymphoblastic lymphoma colon cancer

microcephaly acute leukemia pancreatic cancer colorectal cancer

prostate cancer breast cancer pancreatitis leukemia

prostatitis

3 Novoseek disease relationships for CDT1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cancer	23.3	16	19487297 (2), 16835273 (2), 18508524 (2), 15291814 (2) (see all 7)
colon cancer	0	2	16273206 (2)
tumors	0	3	18508524 (1), 8144677 (1)

Human Genome Epidemiology (HuGE) Navigator: CDT1 (1 document)

Export disorders for CDT1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for CDT1 gene, integrated from 9 sources (see all 181):
(articles sorted by number of sources associating them with CDT1)

Utopia: connect your pdf to the dynamic
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Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding. (PubMed id 14993212)^{1, 2, 9} Sugimoto N.... Fujita M. (2004)
Inhibition of eukaryotic DNA replication by geminin binding to Cdt1. (PubMed id 11125146)^{1, 2, 9} Wohlschlegel J.A....Dutta A. (2000)
Human geminin promotes pre-RC formation and DNA replication by stabilizing CDT1 in mitosis. (PubMed id 15257290)^{1, 2, 9} Ballabeni A....Helin K. (2004)
The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase. (PubMed id 11555648)^{1, 3, 9} Nishitani H....Nishimoto T. (2001)
A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. (PubMed id 16949367)^{1, 2, 9} Jin J.... Walter J.C. (2006)
JNK1 phosphorylation of Cdt1 inhibits recruitment of HBO1 histone acetylase and blocks replication licensing in response to stress. (PubMed id 21856198)^{1, 2} Miotto B. and Struhl K. (2011)
Mutations in the pre-replication complex cause Meier-Gorlin syndrome. (PubMed id 21358632)^{1, 2} Bicknell L.S....Jackson A.P. (2011)
Mutations in origin recognition complex gene ORC4 cause Meier-Gorlin syndrome. (PubMed id 21358631)^{1, 2} Guernsey D.L.... Samuels M.E. (2011)
L2DTL/CDT2 interacts with the CUL4/DDB1 complex and PCNA and regulates CDT1 proteolysis in response to DNA damage. (PubMed id 16861906)^{1, 2} Higa L.A.... Zhang H. (2006)
DTL/CDT2 is essential for both CDT1 regulation and the early G2/M checkpoint. (PubMed id 17085480)^{1, 2} Sansam C.L....Lees J.A. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 81620	HGNC: 24576	AceView: CDT1	Ensembl:ENSG00000167513	euGenes: HUgn81620
ECgene: CDT1	H-InvDB: CDT1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CDT1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CDT1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CDT1 gene:
Search GeneIP for patents involving CDT1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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